SCI时时刷

search
+
Extracellular vesicle encapsulated nicotinamide delivered via a trans-scleral route provides retinal ganglion cell neuroprotection
Extracellular vesicle encapsulated nicotinamide delivered via a trans-scleral route provides retinal ganglion cell neuroprotection
The progressive and irreversible degeneration of retinal ganglion cells (RGCs) and their axons is the major characteristic...
Mouse serum albumin induces neuronal apoptosis and tauopathies
Mouse serum albumin induces neuronal apoptosis and tauopathies
The elderly frequently present impaired blood–brain barrier which is closely associated with various neurodegenerati...
Multidimensional LC-MS with 1D multi-method option and parallel middle-up and bottom-up MS acquisition for in-depth characterization of antibodies
Multidimensional LC-MS with 1D multi-method option and parallel middle-up and bottom-up MS acquisition for in-depth characterization of antibodies
Early twentieth century, Paul Ehrlich reported on “magic bullets” to cure a wide range of diseases thereby visionarily ref...
Unravelling variations: an examination of entry point selection in proximal femoral cephalomedullary nailing
Unravelling variations: an examination of entry point selection in proximal femoral cephalomedullary nailing
The exact positioning of the cephalomedullary (CM) nail entry point for managing femoral fractures remains debatable, with...
Autogenous structural bone graft reconstruction of ≥ 10-mm-deep uncontained medial proximal tibial defects in primary total knee arthroplasty
Autogenous structural bone graft reconstruction of ≥ 10-mm-deep uncontained medial proximal tibial defects in primary total knee arthroplasty
Management of uncontained medial proximal tibial defects during primary total knee arthroplasty (TKA) can be challenging, ...
Separation of ochratoxins by centrifugal partition chromatography
Separation of ochratoxins by centrifugal partition chromatography
The present research work was dedicated to developing an efficient method based on liquid-liquid chromatography (centrifug...
Affinity purification of mAb from serum-containing hybridoma culture supernatant through a novel nanobody that discriminates mouse IgG from bovine IgG by recognizing the mouse kappa constant region (mCK)
Affinity purification of mAb from serum-containing hybridoma culture supernatant through a novel nanobody that discriminates mouse IgG from bovine IgG by recognizing the mouse kappa constant region (mCK)
Hybridoma technology is widely used to generate monoclonal antibodies, as the method can retain native heavy/light chain p...
Stage-dependent immunity orchestrates AQP4 antibody-guided NMOSD pathology: a role for netting neutrophils with resident memory T cells in situ
Stage-dependent immunity orchestrates AQP4 antibody-guided NMOSD pathology: a role for netting neutrophils with resident memory T cells in situ
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disease of the CNS characterized by the production of dise...
BTK inhibition limits microglia-perpetuated CNS inflammation and promotes myelin repair
BTK inhibition limits microglia-perpetuated CNS inflammation and promotes myelin repair
In multiple sclerosis (MS), persisting disability can occur independent of relapse activity or development of new central ...
Mendelian randomization and colocalization analysis reveal novel drug targets for myasthenia gravis
Mendelian randomization and colocalization analysis reveal novel drug targets for myasthenia gravis
Myasthenia gravis (MG) is a complex autoimmune disease affecting the neuromuscular junction with limited drug options, but...
GEN1 as a risk factor for human congenital anomalies of the kidney and urinary tract
GEN1 as a risk factor for human congenital anomalies of the kidney and urinary tract
Congenital anomalies of the kidney and urinary tract (CAKUT) are prevalent birth defects. Although pathogenic CAKUT genes ...
Prioritization of therapeutic targets for cancers using integrative multi-omics analysis
Prioritization of therapeutic targets for cancers using integrative multi-omics analysis
The integration of transcriptomic, proteomic, druggable genetic and metabolomic association studies facilitated a comprehe...
Fresh or frozen day 6 blastocyst transfer: is there still a question?
Fresh or frozen day 6 blastocyst transfer: is there still a question?
The Live Birth Rate (LBR) after day 5 (D5) blastocyst transfer is significantly higher than that with D6 embryos in both f...
Breaking the Barrier: The Role of Gut Epithelial Permeability in the Pathogenesis of Hypertension
Breaking the Barrier: The Role of Gut Epithelial Permeability in the Pathogenesis of Hypertension
To review what intestinal permeability is and how it is measured, and to summarise the current evidence linking altered in...
Investigation of protein/DNA binding, and in vitro cytotoxicity of novel Cu (II) and Zn (II)-dipyrazinyl pyridine complexes
Two new transition metal complexes of a dipyrazinylpyridine (dppy) ligand 3,4-diethoxyphenyl-2,6-di(pyrazine-2-yl)pyridine...
Comparative Analysis of Sulfated and Sulfonated Disaccharide Analogs as TLR4 Modulators and Heparanase Inhibitors
This article delves into the synthesis and biological evaluation of sulfated and sulfonated disaccharide analogs, explorin...
High Throughput Automated Characterization of Enamel Microstructure using Synchrotron Tomography and Optical Flow Imaging
High Throughput Automated Characterization of Enamel Microstructure using Synchrotron Tomography and Optical Flow Imaging
Enamel, the outer protective coating of teeth, is an extremely hard mineral-based material. It exhibits distinct character...
Deciphering protein-mediated underwater adhesion in an invasive biofouling ascidian: discovery, validation, and functional mechanism of an interfacial protein
Deciphering protein-mediated underwater adhesion in an invasive biofouling ascidian: discovery, validation, and functional mechanism of an interfacial protein
Bioadhesion, the attachment of fouling organisms to submerged substrates mediated by natural biological macromolecules, is...
Local anesthetic delivery systems for the management of postoperative pain
Local anesthetic delivery systems for the management of postoperative pain
Postoperative pain (POP) caused by surgical injury to the skin, fascia, mucosa, and small nerves innervating these tissues...
Glycopeptide-based Multifunctional Nanofibrous Hydrogel that Facilitates the Healing of Diabetic Wounds Infected with Methicillin-resistant Staphylococcus aureus
Glycopeptide-based Multifunctional Nanofibrous Hydrogel that Facilitates the Healing of Diabetic Wounds Infected with Methicillin-resistant Staphylococcus aureus
Diabetes is a highly prevalent disease worldwide, and the majority of patients with diabetes experience wound ulcers durin...
Upregulation of circ_0076684 in osteosarcoma facilitates malignant processes by mediating miRNAs/CUX1
Upregulation of circ_0076684 in osteosarcoma facilitates malignant processes by mediating miRNAs/CUX1
Circular RNAs (circRNAs) are a newly appreciated type of endogenous noncoding RNAs that play vital roles in the developmen...
A Novel growth guidance system for early onset scoliosis: a preliminary in vitro study
A Novel growth guidance system for early onset scoliosis: a preliminary in vitro study
The purpose of the study was to describe a novel growth guidance system, which can avoid metal debris and reduce the slidi...
Investigating the impact of cartilaginous endplate herniation on recovery from percutaneous endoscopic lumbar discectomy
Investigating the impact of cartilaginous endplate herniation on recovery from percutaneous endoscopic lumbar discectomy
This study aimed to evaluate the influence of herniation of cartilaginous endplates on postoperative pain and functional r...
Outcomes of surgical treatment of patellar instability in children with Down syndrome
Outcomes of surgical treatment of patellar instability in children with Down syndrome
patellar instability is a relatively frequent musculoskeletal disorder in children with Down syndrome (DS). However, such ...
Does testosterone underly the interplay between male traits and territorial behavior in neotropical poison frogs?
Does testosterone underly the interplay between male traits and territorial behavior in neotropical poison frogs?
Volume 162, June 2024, 105547Author links open overlay panel, , , Highlights•Morphology, calls, and testosterone correlate...
Prolactin is associated with proximity to incubating partner rather than parental care in black-headed gulls
Prolactin is associated with proximity to incubating partner rather than parental care in black-headed gulls
The peptide hormone prolactin plays an important role in the expression of parental care behaviours across bird and mammal...
Developmental exposure to 17-α-hydroxyprogesterone caproate disrupts decision-making in adult female rats: A potential role for a dopaminergic mechanism
Developmental exposure to 17-α-hydroxyprogesterone caproate disrupts decision-making in adult female rats: A potential role for a dopaminergic mechanism
The synthetic progestin, 17-α-hydroxyprogesterone caproate (17-OHPC), is prescribed during gestation with the intent of re...
Design and Expression of Recombinant cell Penetrating Protein Based on Tat and pertussis-like Toxin A and Evaluation of its Effects on the lung cancer
Design and Expression of Recombinant cell Penetrating Protein Based on Tat and pertussis-like Toxin A and Evaluation of its Effects on the lung cancer
Nowadays, design of cytotoxic agents based on microbial toxins is attracted for researchers. Pertussis-like toxin subunit ...
Toxic effects of local anesthetics on rat fibroblasts: An in-vitro study
Toxic effects of local anesthetics on rat fibroblasts: An in-vitro study
Many efforts are made between orthopedic surgeons and anesthesiologists to improve the perioperative pain control of patie...
First ray mobility in hallux rigidus, hallux valgus, and normal feet based on weightbearing computed tomography and three-dimensional analysis: A case-control study
First ray mobility in hallux rigidus, hallux valgus, and normal feet based on weightbearing computed tomography and three-dimensional analysis: A case-control study
Hallux rigidus is a pathological condition affecting the great toe and, after hallux valgus, is the second most common foo...
阅读更多
format_indent_increase