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New generation fluoroquinolone sitafloxacin could potentially overcome the majority levofloxacin and moxifloxacin resistance in multidrug-resistant Mycobacterium tuberculosis
New generation fluoroquinolone sitafloxacin could potentially overcome the majority levofloxacin and moxifloxacin resistance in multidrug-resistant Mycobacterium tuberculosis
Introduction. Pre-existing fluoroquinolones (FQs) resistance is a major threat in treating multidrug-resistant (MDR) tuber...
Synoviocytes assist in modulating the effect of Ross River virus infection in micromass-cultured primary human chondrocytes
Synoviocytes assist in modulating the effect of Ross River virus infection in micromass-cultured primary human chondrocytes
Introduction. Ross River virus (RRV) is a mosquito-borne virus prevalent in Australia and the islands of the South Pacific...
The state of play of rodent models for the study of Clostridioides difficile infection
The state of play of rodent models for the study of Clostridioides difficile infection
Clostridioides difficile is the most common cause of nosocomial antibiotic-associated diarrhoea and is responsible for a s...
Measles outbreak in 2019: a warning for the post-COVID-19 pandemic period
Measles outbreak in 2019: a warning for the post-COVID-19 pandemic period
Introduction. At the end of 2019 and the year before, there was a significant spread of measles in the World Health Organi...
Apramycin has high in vitro activity against Mycobacterium tuberculosis
Apramycin has high in vitro activity against Mycobacterium tuberculosis
Introduction. Aminoglycoside antibiotics such as amikacin and kanamycin are important components in the treatment of Mycob...
Intranasal administration of DSM 32444 Bacillus subtilis spores: safety and tolerability
Intranasal administration of DSM 32444 Bacillus subtilis spores: safety and tolerability
Introduction. Administered nasally, spores of the Gram-positive bacterium Bacillus subtilis have been shown to be able to ...
The role of N-acetylcysteine on adhesion and biofilm formation of Candida parapsilosis isolated from catheter-related candidemia
The role of N-acetylcysteine on adhesion and biofilm formation of Candida parapsilosis isolated from catheter-related candidemia
Objectives. Anti-fungal agents are increasingly becoming less effective due to the development of resistance. In addition,...
Enrichment culture evaluation and characterization of Streptococcus agalactiae among pregnant women in Japan
Enrichment culture evaluation and characterization of Streptococcus agalactiae among pregnant women in Japan
Introduction. Maternal screening tests and prophylactic antibiotics are important to prevent neonatal and infant group B s...
Molecular characterization of Pseudomonas aeruginosa from diabetic foot infections in Tunisia
Molecular characterization of Pseudomonas aeruginosa from diabetic foot infections in Tunisia
Background. Pseudomonas aeruginosa is an invasive organism that frequently causes severe tissue damage in diabetic foot ul...
Antifungal activity of propafenone on Candida spp. strains: interaction with antifungals and possible mechanism of action
Antifungal activity of propafenone on Candida spp. strains: interaction with antifungals and possible mechanism of action
Introduction. The development of new antifungal drugs has become a global priority, given the increasing cases of fungal d...
Dengue virus (DV) non-cross-reactive Omicron wave COVID-19 serums enhanced DV3 infectivity in vitro
Dengue virus (DV) non-cross-reactive Omicron wave COVID-19 serums enhanced DV3 infectivity in vitro
Introduction. In India, the SARS-CoV-2 Delta wave (2020–2021) faded away with the advent of the Omicron variants (2021–pre...
Detection of avian reovirus (ARV) by ELISA based on recombinant σB, σC and σNS full-length proteins and protein fragments
Detection of avian reovirus (ARV) by ELISA based on recombinant σB, σC and σNS full-length proteins and protein fragments
Introduction. Avian reovirus (ARV) is associated with arthritis/tenosynovitis and malabsorption syndrome in chickens. The ...
Improving the diagnosis of urinary tract infections by the use of enriched media and a 48-hour incubation period
Improving the diagnosis of urinary tract infections by the use of enriched media and a 48-hour incubation period
Introduction. The absence of a gold-standard methodology for the microbiological diagnosis of urinary tract infections (UT...
Ciprofloxacin prophylaxis during haematopoietic cell transplantation: a role for use in patients with germ cell tumours?
Ciprofloxacin prophylaxis during haematopoietic cell transplantation: a role for use in patients with germ cell tumours?
Introduction. Fluoroquinolone prophylaxis during haematopoietic cell transplantation (HCT) can lead to antimicrobial resis...
Antimicrobial resistance patterns among critical priority pathogens in an intensive care unit at a tertiary hospital in Egypt: a descriptive analysis comparing pre- and COVID-19 eras
Antimicrobial resistance patterns among critical priority pathogens in an intensive care unit at a tertiary hospital in Egypt: a descriptive analysis comparing pre- and COVID-19 eras
Background. The intensified global challenge of antimicrobial resistance, set against the backdrop of the COVID-19 pandemi...
Levels of 5α-reductase gene in intestinal lavage fluid decrease with progression of colorectal cancer
Levels of 5α-reductase gene in intestinal lavage fluid decrease with progression of colorectal cancer
Introduction. Colorectal cancer (CRC) is a leading cause of cancer deaths, closely linked to the intestinal microbiota and...
Colistin utilization at a tertiary hospital in South Africa: an opportunity for antimicrobial stewardship practices
Colistin utilization at a tertiary hospital in South Africa: an opportunity for antimicrobial stewardship practices
Introduction. Colistin (polymyxin E) has emerged as a last-resort treatment option for multidrug-resistant infections. Hyp...
Characterization of Aspergillus fumigatus secretome during sublethal infection of Galleria mellonella larvae
Characterization of Aspergillus fumigatus secretome during sublethal infection of Galleria mellonella larvae
Introduction. The fungal pathogen Aspergillus fumigatus can induce prolonged colonization of the lungs of susceptible pati...
The laboratory investigation, management, and infection prevention and control of Candida auris: a narrative review to inform the 2024 national guidance update in England
The laboratory investigation, management, and infection prevention and control of Candida auris: a narrative review to inform the 2024 national guidance update in England
The emergent fungal pathogen Candida auris is increasingly recognised as an important cause of healthcare-associated infec...
Infectious bronchitis virus: an overview of the “chicken coronavirus”
Infectious bronchitis virus: an overview of the “chicken coronavirus”
Infectious bronchitis virus (IBV) is a highly contagious avian Gammacoronavirus that affects mainly chickens (Gallus gallu...
Genetic variations of penicillin-binding protein 1A: insights into the current status of amoxicillin-based regimens for Helicobacter pylori eradication in Malaysia
Genetic variations of penicillin-binding protein 1A: insights into the current status of amoxicillin-based regimens for Helicobacter pylori eradication in Malaysia
Introduction. Resistance towards amoxicillin in Helicobacter pylori causes significant therapeutic impasse in healthcare s...
Rhein kills Actinobacillus pleuropneumoniae, reduces biofilm formation, and effectively treats bacterial lung infections in mice
Rhein kills Actinobacillus pleuropneumoniae, reduces biofilm formation, and effectively treats bacterial lung infections in mice
Background. Actinobacillus pleuropneumoniae, a member of the Pasteurellaceae family, is known for its highly infectious na...
CXCR2 perturbation promotes Staphylococcus aureus implant-associated infection
CXCR2 perturbation promotes Staphylococcus aureus implant-associated infection
Introduction. Staphylococcus aureus is the leading cause of acute medical implant infections, representing a significant m...
Characterization of invasive Group B Streptococcus isolates from Western Australian infants, 2004–2020
Characterization of invasive Group B Streptococcus isolates from Western Australian infants, 2004–2020
Background. Invasive Group B Streptococcus (GBS; Streptococcus agalactiae) remains a leading cause of infant morbidity and...
Exploring the diversity of vaginal microbiota between healthy women and cervical cancer patients in India
Exploring the diversity of vaginal microbiota between healthy women and cervical cancer patients in India
Introduction. Cervicovaginal diversity has been reported as a predictive biomarker for cervical cancer risk. We recently r...
Anthraquinones against Cryptococcus neoformans sensu stricto: antifungal interaction, biofilm inhibition and pathogenicity in the Caenorhabditis elegans model
Anthraquinones against Cryptococcus neoformans sensu stricto: antifungal interaction, biofilm inhibition and pathogenicity in the Caenorhabditis elegans model
Introduction. Cryptococcal biofilms have been associated with persistent infections and antifungal resistance. Therefore, ...
Clostridioides difficile detection and infection in children: are they just small adults?
Clostridioides difficile detection and infection in children: are they just small adults?
Clostridioides difficile is a well-recognized healthcare-associated pathogen, with its significance widely recognized in a...
Listeria monocytogenes: the silent assassin
Listeria monocytogenes: the silent assassin
Listeriosis is a foodborne infection in humans caused by Listeria monocytogenes. Consumption of contaminated food can lead...
In vitro and in silico assessment of anti-biofilm and anti-quorum sensing properties of 2,4-Di-tert butylphenol against Acinetobacter baumannii
In vitro and in silico assessment of anti-biofilm and anti-quorum sensing properties of 2,4-Di-tert butylphenol against Acinetobacter baumannii
Introduction. Acinetobacter baumannii is a nosocomial pathogen with a high potential to cause food-borne infections. It is...
Delays to treatment initiation and emergence of drug resistance among new adult tuberculosis patients in Tigray, Northern Ethiopia
Delays to treatment initiation and emergence of drug resistance among new adult tuberculosis patients in Tigray, Northern Ethiopia
Introduction. Studies in Ethiopia have indicated that tuberculosis (TB) patient’s elapsed a long time before initiating tr...
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