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Deciphering the genetic basis of resistome and virulome diversity among multidrug-resistant Mycoplasma hominis
Deciphering the genetic basis of resistome and virulome diversity among multidrug-resistant Mycoplasma hominis
Mycoplasma hominis is one of the smallest pathogens responsible for a diverse range of infections, including non-gonococca...
Combating Bacterial Infections with Host Defense Peptides: Shifting Focus from Bacteria to Host Immunity
Combating Bacterial Infections with Host Defense Peptides: Shifting Focus from Bacteria to Host Immunity
The continued ravages of multidrug-resistant (MDR) bacteria threaten public health and food security (Breidenstein et al.,...
Overexpression of ABCC1 and ABCG2 Confers Resistance to Talazoparib, a Poly (ADP-Ribose) Polymerase Inhibitor
Overexpression of ABCC1 and ABCG2 Confers Resistance to Talazoparib, a Poly (ADP-Ribose) Polymerase Inhibitor
Multidrug resistance (MDR) is a term used to describe the resistance of cancer cells to multiple chemotherapeutic drugs, w...
The Role of Histone H1.2 in Pancreatic Cancer Metastasis and Chemoresistance
The Role of Histone H1.2 in Pancreatic Cancer Metastasis and Chemoresistance
Pancreatic cancer (PC) remains one of the deadliest cancers globally, with a 5-year survival rate of less than 10% (Siegel...
Cisplatin-activated ERβ/DCAF8 positive feedback loop induces chemoresistance in non-small cell lung cancer via PTEN/Akt axis
Cisplatin-activated ERβ/DCAF8 positive feedback loop induces chemoresistance in non-small cell lung cancer via PTEN/Akt axis
High levels of the estrogen receptor β (ERβ) predict poor prognosis following platinum-containing adjuvant chemotherapies ...
CRISPR/Cas9 screens unravel miR-3689a-3p regulating sorafenib resistance in hepatocellular carcinoma via suppressing CCS/SOD1-dependent mitochondrial oxidative stress
CRISPR/Cas9 screens unravel miR-3689a-3p regulating sorafenib resistance in hepatocellular carcinoma via suppressing CCS/SOD1-dependent mitochondrial oxidative stress
KeywordsIn vivo CRISPR/Cas9 screenSorafenibMiR-3689a-3pDrug resistance of hepatocellular carcinomaCCSData availability sta...
Promising role of protein arginine methyltransferases in overcoming anti-cancer drug resistance
Promising role of protein arginine methyltransferases in overcoming anti-cancer drug resistance
Drug resistance remains a major challenge in cancer treatment, necessitating the development of novel strategies to overco...
ABCC4 Impacts Megakaryopoiesis and Protects Megakaryocytes against 6-Mercaptopurine Induced Cytotoxicity
ABCC4 Impacts Megakaryopoiesis and Protects Megakaryocytes against 6-Mercaptopurine Induced Cytotoxicity
Production of platelets by their progenitors, the megakaryocytes (MKs) is referred to as megakaryopoiesis. Megakaryocyte p...
Cuproptosis: a novel therapeutic target for overcoming cancer drug resistance
Cuproptosis: a novel therapeutic target for overcoming cancer drug resistance
Available online 11 November 2023, 101018Author links open overlay panel, , , , , , , , , AbstractCuproptosis is a newly i...
MYC expression and Fatty acid oxidation in EGFR-TKI acquired resistance
MYC expression and Fatty acid oxidation in EGFR-TKI acquired resistance
Available online 13 November 2023, 101019Author links open overlay panel, , , AbstractThis report expands on our previous ...
Radioiodine-refractory thyroid cancer: Molecular mechanisms and therapeutic strategies for radioiodine resistance
Radioiodine-refractory thyroid cancer: Molecular mechanisms and therapeutic strategies for radioiodine resistance
Radioiodine refractory differentiated thyroid cancer (RAIR-DTC) is difficult to treat with radioactive iodine because of t...
Antibiotic failure: Beyond antimicrobial resistance
Antibiotic failure: Beyond antimicrobial resistance
Available online 18 October 2023, 101012Author links open overlay panel, , AbstractDespite significant progress in antibio...
Perspectives on drug repurposing to overcome cancer multidrug resistance mediated by ABCB1 and ABCG2
Perspectives on drug repurposing to overcome cancer multidrug resistance mediated by ABCB1 and ABCG2
Available online 10 October 2023, 101011Author links open overlay panel, , ABSTRACTThe overexpression of the human ATP-bin...
Pdr5: A Master of Asymmetry
Pdr5: A Master of Asymmetry
Available online 7 October 2023, 101010Author links open overlay panel, AbstractPdr5 is a founding member of a large (pdr)...
Second-site suppressor mutations reveal connection between the drug-binding pocket and nucleotide-binding domain 1 of human P-glycoprotein (ABCB1)
Second-site suppressor mutations reveal connection between the drug-binding pocket and nucleotide-binding domain 1 of human P-glycoprotein (ABCB1)
Human P-glycoprotein (P-gp) or ABCB1 is overexpressed in many cancers and has been implicated in altering the bioavailabil...
Antibody evasion associated with the RBD significant mutations in several emerging SARS-CoV-2 variants and its subvariants
Antibody evasion associated with the RBD significant mutations in several emerging SARS-CoV-2 variants and its subvariants
Since the origin of the wild strain of SARS-CoV-2, several variants have emerged, which were designated as VOC, VOI, and V...
Effective targeting of breast cancer by the inhibition of P-glycoprotein mediated removal of toxic lipid peroxidation byproducts from drug tolerant persister cells
Effective targeting of breast cancer by the inhibition of P-glycoprotein mediated removal of toxic lipid peroxidation byproducts from drug tolerant persister cells
List of abbreviationsABCATP-binding cassette (ABC)DTPDrug-tolerant persisterMMPMatched molecular pairP-gpP-glycoprotein (A...
The definition and global epidemiology of nonmobile colistin resistance (NMCR-3) determinants in Aeromonas from 1968 to 2022
The definition and global epidemiology of nonmobile colistin resistance (NMCR-3) determinants in Aeromonas from 1968 to 2022
KeywordsNonmobile colistin resistanceNMCR-3AeromonasNatural reservoir/progenitorMCR-3/5/7Global prevalenceData availabilit...
CircPTEN suppresses human clear cell renal carcinoma progression and resistance to mTOR inhibitors by targeting epigenetic modification
CircPTEN suppresses human clear cell renal carcinoma progression and resistance to mTOR inhibitors by targeting epigenetic modification
Available online 2 September 2023, 101003Author links open overlay panel, , , , , , , , , , , , AbstractRenal cell carcino...
Cell membrane-camouflaged bufalin targets NOD2 and overcomes multidrug resistance in pancreatic cancer
Cell membrane-camouflaged bufalin targets NOD2 and overcomes multidrug resistance in pancreatic cancer
AimsMultidrug resistance in pancreatic cancer poses a significant challenge in clinical treatment. Bufalin (BA), a compoun...
Natural medicinal compounds target signal transduction pathways to overcome ABC drug efflux transporter-mediated multidrug resistance in cancer
Natural medicinal compounds target signal transduction pathways to overcome ABC drug efflux transporter-mediated multidrug resistance in cancer
ABC transporterATP-binding cassette transporterAMLAcute myeloid leukemiaAHRAryl hydrocarbon receptorAREAntioxidant respons...
Treatment Strategies and Drug Resistance Mechanisms in Adenocarcinoma of Different Organs
Treatment Strategies and Drug Resistance Mechanisms in Adenocarcinoma of Different Organs
Adenocarcinoma is a common type of malignant tumor, originating from glandular epithelial cells in various organs, such as...
H3K4me3 remodeling induced acquired resistance through O-GlcNAc transferase
H3K4me3 remodeling induced acquired resistance through O-GlcNAc transferase
AimsDrivers of the drug tolerant proliferative persister (DTPP) state have not been well investigated. Histone H3 lysine-4...
Structure, function, and inhibition of catalytically asymmetric ABC transporters: lessons from the PDR subfamily
Available online 5 August 2023, 100992Author links open overlay panel, , , , , AbstractATP-binding cassette (ABC) superfam...
NR5A2/HSD3B1 pathway promotes cellular resistance to second-generation antiandrogen darolutamide
This study investigated cellular mechanisms in steroidogenesis responsible for treatment resistance to the novel antiandro...
Identification of TMexCD-TOprJ-producing carbapenem-resistant Gram-negative bacteria from hospital sewage
Carbapenems and tigecycline are crucial antimicrobials for the treatment of gram-negative bacteria infections. Recently, a...
Purinergic signalling in cancer therapeutic resistance: from mechanisms to targeting strategies
Available online 28 June 2023, 100988Author links open overlay panel, , , , , , , , , AbstractPurinergic signalling, consi...
New emerging SARS-CoV-2 variants and antiviral agents
Available online 26 June 2023, 100986Author links open overlay panelA. Vitiello 1, A. Zovi, G. RezzaShow moreKeywordscovid...
Elevated NOX4 promotes tumorigenesis and acquired EGFR-TKIs resistance via enhancing IL-8/PD-L1 signaling in NSCLC
Available online 22 June 2023, 100987Author links open overlay panel, , , , , , , , , , , AbstractEpidermal growth factor ...
Inhibition of Phosphoglycerate dehydrogenase induces ferroptosis and overcomes enzalutamide resistance in castration-resistant prostate cancer cells
Available online 14 June 2023, 100985Author links open overlay panel, , , , , , , , , , ABSTRACTPhosphoglycerate dehydroge...
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