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Targeting ACYP1-mediated glycolysis reverses lenvatinib resistance and restricts hepatocellular carcinoma progression
Available online 16 May 2023, 100976Author links open overlay panel, , , , , , , , , , AbstractAcylphosphatase 1 (ACYP1), ...
lncRNA SYTL5-OT4 promotes vessel co-option by inhibiting the autophagic degradation of ASCT2
AbbreviationAATsantiangiogenic therapiesASCT2alanine-serine-cysteine transporter 2B.R.bevacizumab resistanceCRCLMcolorecta...
GATA3 mediates doxorubicin resistance by inhibiting CYB5R2-catalyzed iron reduction in breast cancer cells
Available online 9 May 2023, 100974Author links open overlay panel, , , , , , , , , AbstractAimsNeoadjuvant chemotherapy (...
Overexpression of blaGES-1 due to a strong promoter in the class 1 integron contributes to decreased ceftazidime-avibactam susceptibility in carbapenem-resistant Pseudomonas aeruginosa ST235
Available online 2 May 2023, 100973Author links open overlay panel, , , , , , , , AbstractSequence type 235 (ST235) Pseudo...
Targeting Myc-driven stress addiction in colorectal cancer
APCsantigen presenting cellsATF4activating transcription factor 4ATF6activating transcription factor 6BETBromodomain and e...
Current therapy and drug resistance in metastatic castration-resistant prostate cancer
Castration-resistant prostate cancer (CRPC), especially metastatic castration-resistant prostate cancer (mCRPC) is one of ...
Pyrazinamide-resistant Tuberculosis Obscured From Common Targeted Molecular Diagnostics
Available online 6 April 2023, 100959Author links open overlay panel, , , , , AbstractHere, we describe a clinical case of...
Cancer-associated fibroblasts suppress ferroptosis and induce gemcitabine resistance in pancreatic cancer cells by secreting exosome-derived ACSL4-targeting miRNAs
BackgroundPancreatic cancer continues to be one of the world's most lethal cancers. Chemotherapy resistance in patients wi...
Collateral sensitivity between tetracyclines and aminoglycosides constrains resistance evolution in carbapenem-resistant Klebsiella pneumoniae
AimsThe acquisition of resistance to one antibiotic may confer an increased sensitivity to another antibiotic in bacteria,...
A phosphoglycerate mutase 1 allosteric inhibitor overcomes drug resistance to EGFR-targeted therapy via disrupting IL-6/JAK2/STAT3 signaling pathway in lung adenocarcinoma
Resistance to epidermal growth factor receptor (EGFR) inhibitors, from the first-generation erlotinib to the third generat...
The heterogeneous transition state of resistance to RET kinase inhibitors converges on ERK1/2-driven Aurora A/B kinases
AimWhile most patients with RET-altered cancer responded to the RET protein tyrosine kinase inhibitors (TKIs) pralsetinib ...
The heterogenous transition state of resistance to RET kinase inhibitors converges on ERK1/2-driven Aurora A/B kinases
Available online 24 March 2023, 100958Author links open overlay panel, , , AbstractAimWhile most patients with RET-altered...
A phosphoglycerate mutase 1 allosteric inhibitor overcomes drug resistance to EGFR-targeted therapy via disrupting IL-6/JAK2/STAT3 signaling pathway in lung adenocarcinoma
Resistance to epidermal growth factor receptor (EGFR) inhibitors, from the first-generation erlotinib to the third generat...
Nanocarriers overcoming biological barriers induced by multidrug resistance of chemotherapeutics in 2D and 3D cancer models
Multidrug resistance (MDR) is currently a big challenge in cancer therapy and limits its success in several patients. Tumo...
Antimicrobial peptides for combating drug-resistant bacterial infections
Volume 68, May 2023, 100954Author links open overlay panel, , , , , , , , AbstractThe problem of drug resistance due to lo...
Synergistic antiviral activity against drug-resistant HIV-1 by naturally occurring dipeptide and A single-stranded oligonucleotide
Volume 68, May 2023, 100955Author links open overlay panel, , AbstractThe novel dipeptide WG-am and single-stranded oligon...
Global population structure and genomic surveillance framework of carbapenem-resistant Salmonella enterica
Volume 68, May 2023, 100953Author links open overlay panel, , , , , , AbstractDue to the frequent international and interc...
Carbapenemase-loaded outer membrane vesicles protect Pseudomonas aeruginosa by degrading imipenem and promoting mutation of antimicrobial resistance gene
AimsTo investigate the effect of Klebsiella pneumoniae carbapenemase (KPC)-loaded outer membrane vesicles (OMVs) in protec...
Carbapenemase-loaded outer membrane vesicles protect Pseudomonas aeruginosa by degrading imipenem and promoting mutation of antimicrobial resistance gene
AimsTo investigate the effect of Klebsiella pneumoniae carbapenemase (KPC)-loaded outer membrane vesicles (OMVs) in protec...
Replacing the tropolonic methoxyl group of colchicine with methylamino increases tubulin binding affinity with improved therapeutic index and overcomes paclitaxel cross-resistance
Available online 13 February 2023, 100951Author links open overlay panel, , , , , , , , , , , ABSTRACTAimsMicrotubule inhi...
CRISPR-Cas system as a promising player against bacterial infection and antibiotic resistance
Volume 68, May 2023, 100948Author links open overlay panel, , , , , AbstractThe phenomenon of antibiotic resistance (AR) a...
Regulation of Cisplatin Resistance in Bladder Cancer by Epigenetic Mechanisms
NMIBCNonmuscle invasive bladder cancerMIBCMuscle invasive bladder cancerTLX3T-cell leukemia homeobox 3GULP1Engulfment adap...
PDPN Positive CAFs Contribute to HER2 Positive Breast Cancer Resistance to Trastuzumab by Inhibiting Antibody-dependent NK Cell-mediated Cytotoxicity
Available online 9 February 2023, 100947Author links open overlay panel, , , , , , , , , , AbstractTrastuzumab is a humani...
Radioiodine Therapy in Advanced Differentiated Thyroid Cancer: Resistance and Overcoming Strategy
AbbreviationADAbsorbed Radiation DoseAPLAcute Promyelocytic LeukemiaATRAAll-Trans Retinoic AcidCAFCancer-Associated Fibrob...
Exosomal circular RNAs: A chief culprit in cancer chemotherapy resistance
Volume 67, March 2023, 100937Author links open overlay panel, , , AbstractChemotherapy is one of the primary treatments fo...
Exosomal circular RNAs: a chief culprit in chemotherapy resistance in cancer
Available online 2 February 2023, 100937Author links open overlay panel, , , AbstractChemotherapy is one of the primary tr...
Silver-dendrimer nanocomposite as emerging therapeutics in anti-bacteria and beyond
Available online 29 January 2023, 100935Author links open overlay panelAbstractTo develop next-generation nanomedicine, th...
Loss of cancer-associated fibroblast-derived exosomal DACT3-AS1 promotes malignant transformation and ferroptosis-mediated oxaliplatin resistance in gastric cancer
Available online 31 January 2023, 100936Author links open overlay panelAbstractAimsLong non-coding RNAs (lncRNAs), as one ...
CPSF6-mediated XBP1 3’UTR shortening attenuates cisplatin-induced ER stress and elevates chemo-resistance in lung adenocarcinoma
Available online 25 January 2023, 100933Author links open overlay panelAbstractAlternative polyadenylation (APA) is a wide...
Mapping Cryptic Binding Sites of Drug Targets to Overcome Drug Resistance
Available online 23 January 2023, 100934Author links open overlay panelABSTRACTThe emergence of drug resistance is a prima...
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