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Opposite evolution of pathogenicity driven by in vivo wzc and wcaJ mutations in ST11-KL64 carbapenem-resistant Klebsiella pneumoniae
The Illumina sequencing data of K. pneumoniae isolate FS was deposited in NCBI under accession number SAMN12045482. The Pa...
A highly potent small-molecule antagonist of exportin-1 selectively eliminates CD44+CD24- enriched breast cancer stem-like cells
Available online 20 November 2022, 100903Author links open overlay panelAbstractBreast cancer stem-like cells (BCSCs) have...
Resistance-proof antimicrobial drug discovery to combat global antimicrobial resistance threat
Available online 17 November 2022, 100890Highlights•Microbes survive under antibiotic stress due to a microbe-supportive s...
Precision Medicine: Ray of Hope in Overcoming Cancer Multidrug Resistance
Available online 9 November 2022, 100889AbstractMulti-drug resistance (MDR) developed in response to chemotherapy is one o...
Paclitaxel resistance related to nuclear envelope structural sturdiness
Volume 65, December 2022, 100881AbstractTaxanes (Taxol/paclitaxel, Docetaxel/taxotere) are a key group of successful drugs...
Harnessing mitochondrial metabolism and drug resistance in non-small cell lung cancer and beyond by blocking heat-shock proteins
Volume 65, December 2022, 100888AbstractLung cancer is the leading cause of cancer-related deaths worldwide, with non-smal...
Dual use of antifungals in medicine and agriculture: How do we help prevent resistance developing in human pathogens?
Available online 20 October 2022, 100885Highlights•Azole resistance in Aspergillus fumigatus is a One Health resistance th...
Paclitaxel Resistance Related to Nuclear Envelope Structural SturdinessRunning Title: Lamin A/C Expression and Paclitaxel Resistance
Available online 15 October 2022, 100881ABSTRACTTaxanes (Taxol/paclitaxel, Docetaxel/taxotere) are a key group of successf...
Corrigendum to “Molecular basis of bacterial disinfectant resistance” [Drug Resist. Updates 48 (2020) 100672]
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Targeting Feedback Activation of Signaling Transduction Pathways to Overcome Drug Resistance in Cancer.
Available online 13 October 2022, 100884AbstractDysregulation or aberrant signaling transduction contributes to tumorigene...
The Omicron Variant of Concern: Diversification and Convergent Evolution in Spike Protein, and Escape From Anti-spike Monoclonal Antibodies
Available online 3 October 2022, 100882AbstractWHO-defined SARS-CoV-2 variants of concern (VOC) drive therapeutics and vac...
Monitoring tumour resistance to the BRAF inhibitor combination regimen in colorectal cancer patients via circulating tumour DNA
Available online 29 September 2022, 100883Highlights•ctDNA BRAF can reflect the tumour burden with aggressive clinical cha...
Long Non-coding RNAs (lncRNAs) signaling in Cancer Chemoresistance: From Prediction to Druggability
The acquisition of cancer cell resistance to conventional chemotherapeutics is considered the major driver of treatment fa...
Role of drug catabolism, modulation of oncogenic signaling and tumor microenvironment in microbe-mediated pancreatic cancer chemoresistance
Pancreatic ductal adenocarcinoma (PDAC) has one of the highest incidence/death ratios among all neoplasms due to its late ...
Combinatorial approaches of nanotherapeutics for inflammatory pathway targeted therapy of prostate cancer
Prostate cancer (PC) is the most prevalent male urogenital cancer worldwide. PC patients presenting an advanced or metasta...
Genetic alterations shaping tumor response to anti-EGFR therapies
Available online 27 August 2022, 100863AbstractThe Epidermal Growth Factor Receptor (EGFR) has been targeted through the d...
Understanding ER homeostasis and the UPR to enhance treatment efficacy of Acute Myeloid Leukemia
Protein biogenesis, maturation and degradation are tightly regulated processes that are governed by a complex network of s...
Long Non-coding RNA Mediated Drug Resistance in Breast Cancer
LncRNALong non-coding RNAHER2Human epidermal growth factor receptor 2AGAP2-AS1AGAP2 Antisense RNA 1CPT1Carnitine palmitoyl...
New insights into antiangiogenic therapy resistance in cancer: mechanisms and therapeutic aspects
Angiogenesis is a hallmark of cancer and is required for tumor growth and progression. Antiangiogenic therapy has been rev...
Selenium and Tellurium in the development of novel small molecules and nanoparticles as cancer multidrug resistance reversal agents
Available online 2 May 2022, 100844AbstractSelenium is an essential trace element that is crucial for cellular antioxidant...
Revolutionizing non-conventional wound healing using honey by simultaneously targeting multiple molecular mechanisms
Hospital-acquired infections and treatment-related wound complications constitute a tremendous burden for the health care ...
The role of extracellular vesicles in the transfer of drug resistance competences to cancer cells
Drug resistance remains a major hurdle to successful cancer treatment, being accountable for approximately 90% of cancer-r...
Targeting metabolism to overcome cancer drug resistance: A promising therapeutic strategy for diffuse large B cell lymphoma
Cancer cell metabolism including aerobic glycolysis, amino acid and fatty acid metabolism, has been extensively studied. M...
Epigenetic enzyme mutations as mediators of anti-cancer drug resistance
Available online 18 February 2022, 100821AbstractDespite the rapid advancement in the introduction of new drugs for cancer...
Network Biology and Artificial Intelligence Drive the Understanding of the Multidrug Resistance Phenotype in Cancer
Globally with over 10 million deaths per year, cancer is the most transversal disease across countries, cultures, and ethn...
Microenvironment-driven intratumoral heterogeneity in head and neck cancers: clinical challenges and opportunities for precision medicine
αSMAalpha smooth muscle actinARCONaccelerated radiotherapy with carbogen and nicotinamideCAFcancer-associated fibroblastcf...