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Spotlight on Ideal Target Antigens and Resistance in Antibody-Drug Conjugates: Strategies for Competitive Advancement
Spotlight on Ideal Target Antigens and Resistance in Antibody-Drug Conjugates: Strategies for Competitive Advancement
Cancer is a significant public health problem that seriously endangers human health and social development in the world (K...
Heterogeneity of SOS response expression in clinical isolates of Escherichia coli influences adaptation to antimicrobial stress
Heterogeneity of SOS response expression in clinical isolates of Escherichia coli influences adaptation to antimicrobial stress
In recent years, new evidence has shown that the SOS response plays an important role in the response to antimicrobials, w...
Potential targets and therapeutics for cancer stem cell-based therapy against drug resistance in hepatocellular carcinoma
Potential targets and therapeutics for cancer stem cell-based therapy against drug resistance in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the most common digestive malignancy, ranking the sixth-most prevalent cancer and the fo...
Syk-dependent homologous recombination activation promotes cancer resistance to DNA targeted therapy
Syk-dependent homologous recombination activation promotes cancer resistance to DNA targeted therapy
Cells employ a series of repair mechanisms to maintain genome integrity following exposure to endogenous or exogenous dama...
Expansion and transmission dynamics of high risk carbapenem-resistant Klebsiella pneumoniae subclones in China: An epidemiological, spatial, genomic analysis
Expansion and transmission dynamics of high risk carbapenem-resistant Klebsiella pneumoniae subclones in China: An epidemiological, spatial, genomic analysis
AimsCarbapenem-resistant Klebsiella pneumonia (CRKP) is a global threat that varies by region. The global distribution, ev...
Advances in Molecular Targeted Drugs in Combination with CAR-T Cell Therapy for Hematologic Malignancies
Advances in Molecular Targeted Drugs in Combination with CAR-T Cell Therapy for Hematologic Malignancies
Available online 26 March 2024, 101082Author links open overlay panel, , , , , , , , AbstractMolecular targeted drugs and ...
Circumventing Drug Resistance in Gastric Cancer: A Spatial Multi-omics Exploration of Chemo and Immuno-Therapeutic Response Dynamics
Circumventing Drug Resistance in Gastric Cancer: A Spatial Multi-omics Exploration of Chemo and Immuno-Therapeutic Response Dynamics
Gastric cancer (GC) is a prevalent and deadly disease, ranking as the fifth most common cancer and the third leading cause...
Concurrent inhibition of ALK and SRC kinases disrupts the ALK lung tumor cell proteome
Concurrent inhibition of ALK and SRC kinases disrupts the ALK lung tumor cell proteome
Available online 19 March 2024, 101081Author links open overlay panel, , , , , , , , , ABSTRACTPrecision oncology has revo...
TRIM29 facilitates gemcitabine resistance via MEK/ERK pathway and is modulated by circRPS29/miR-770-5p axis in PDAC
TRIM29 facilitates gemcitabine resistance via MEK/ERK pathway and is modulated by circRPS29/miR-770-5p axis in PDAC
Pancreatic ductal adenocarcinoma (PDAC) has emerged as the fourth leading cause of cancer related death, which account for...
Targeted dual degradation of HER2 and EGFR obliterates oncogenic signaling, overcomes therapy resistance, and inhibits metastatic lesions in HER2-positive breast cancer models
Targeted dual degradation of HER2 and EGFR obliterates oncogenic signaling, overcomes therapy resistance, and inhibits metastatic lesions in HER2-positive breast cancer models
AimsHuman epidermal growth factor receptor 2 (HER2) is an oncogenic receptor tyrosine kinase amplified in approximately 20...
A Novel SIK2 Inhibitor SIC-19 exhibits Synthetic Lethality with PARP inhibitors in Ovarian Cancer
A Novel SIK2 Inhibitor SIC-19 exhibits Synthetic Lethality with PARP inhibitors in Ovarian Cancer
AbbreviationsSIK2Salt-Inducible Kinase 2SIC-19SIK2-inhibiting compound 19HRDhomologous recombination deficiencyHRPhomologo...
Solving the antibacterial resistance in Europe: The multipronged approach of the COST Action CA21145 EURESTOP
Solving the antibacterial resistance in Europe: The multipronged approach of the COST Action CA21145 EURESTOP
Carole Seguin-Devaux: Writing – original draft, Conceptualization. Tomislav Mestrovic: Writing – original draft, Conceptua...
Development and evaluation of a human CD47/HER2 bispecific antibody for Trastuzumab-resistant breast cancer immunotherapy
Development and evaluation of a human CD47/HER2 bispecific antibody for Trastuzumab-resistant breast cancer immunotherapy
Breast cancer (BC) is the most common malignancy diagnosed in women worldwide, and the second cause of cancer-related deat...
AI in infectious diseases: The role of datasets
AI in infectious diseases: The role of datasets
Cesar de la Fuente-Nunez holds a Presidential Professorship at the University of Pennsylvania, is a recipient of the Lange...
ABCB1-dependent collateral sensitivity of multidrug-resistant colorectal cancer cells to the survivin inhibitor MX106-4C
ABCB1-dependent collateral sensitivity of multidrug-resistant colorectal cancer cells to the survivin inhibitor MX106-4C
Colorectal cancer is the third most commonly occurring cancer worldwide, with an estimated 1.9 million new cases and 930,0...
Tumor-acquired somatic mutation affects conformation to abolish ABCG2-mediated drug resistance
Tumor-acquired somatic mutation affects conformation to abolish ABCG2-mediated drug resistance
ATP-binding cassette sub-family G member 2, ABCG2, was initially cloned from drug-resistant cancer cells (Austin Doyle et ...
Fibroblast growth factor receptor 1 inhibition suppresses pancreatic cancer chemoresistance and chemotherapy-driven aggressiveness
Fibroblast growth factor receptor 1 inhibition suppresses pancreatic cancer chemoresistance and chemotherapy-driven aggressiveness
Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-associated death in the United States, with 6...
Methylation of GPRC5A promotes liver metastasis and docetaxel resistance through activating mTOR signaling pathway in triple negative breast cancer
Methylation of GPRC5A promotes liver metastasis and docetaxel resistance through activating mTOR signaling pathway in triple negative breast cancer
AimsThis study aims to explore the function and mechanism of G Protein-coupled receptor class C group 5 member A (GPRC5A) ...
Polyphenol nanocomplex modulates lactate metabolic reprogramming and elicits immune responses to enhance cancer therapeutic effect
Polyphenol nanocomplex modulates lactate metabolic reprogramming and elicits immune responses to enhance cancer therapeutic effect
Cancer lactate metabolic reprogramming induces an elevated level of extracellular lactate and H+, leading to an acidic imm...
Target-based drug design strategies to overcome resistance to antiviral agents: opportunities and challenges
Target-based drug design strategies to overcome resistance to antiviral agents: opportunities and challenges
The threat posed by viral infections to human health is a major concern. The COVID-19 pandemic had a profound impact on gl...
Phage-mediated colistin resistance in Acinetobacter baumannii
Phage-mediated colistin resistance in Acinetobacter baumannii
Available online 28 January 2024, 101061Author links open overlay panel, , , , , , , , Highlights•Φ19606 is an Acinetobact...
The Role of ABCC10 / MRP7 in Anti-Cancer Drug Resistance and Beyond
The Role of ABCC10 / MRP7 in Anti-Cancer Drug Resistance and Beyond
The ATP-binding cassette (ABC) transporter superfamily is composed of a variety of membrane transporters located on the ce...
Single-cell Transcriptome Analysis Reveals the Association between Histone Lactylation and Cisplatin Resistance in Bladder Cancer
Single-cell Transcriptome Analysis Reveals the Association between Histone Lactylation and Cisplatin Resistance in Bladder Cancer
Bladder cancer (Bca) is the tenth most common malignant tumor globally, with approximately 500,000 new cases and 200,000 d...
MAFF Confers Vulnerability to Cisplatin-based and Ionizing Radiation Treatments by Modulating Ferroptosis and Cell Cycle Progression in Lung Adenocarcinoma
MAFF Confers Vulnerability to Cisplatin-based and Ionizing Radiation Treatments by Modulating Ferroptosis and Cell Cycle Progression in Lung Adenocarcinoma
Lung cancer is one of the most common and deadly types of cancer (Sung et al., 2021). Presently, lung adenocarcinoma (LUAD...
Drug resistance mechanisms in dopamine agonist-resistant prolactin pituitary neuroendocrine tumors and exploration for new drugs
Drug resistance mechanisms in dopamine agonist-resistant prolactin pituitary neuroendocrine tumors and exploration for new drugs
Pituitary neuroendocrine tumors (PitNETs) are the most common type of benign tumors found in the saddle area. Prolactinoma...
Polyphenol nanocomplex modulats lactate metabolic reprogramming and elicits immune responses to enhance cancer therapeutic effect
Polyphenol nanocomplex modulats lactate metabolic reprogramming and elicits immune responses to enhance cancer therapeutic effect
Cancer lactate metabolic reprogramming induces an elevated level of extracellular lactate and H+, leading to an acidic imm...
Utilizing non-coding RNA-mediated regulation of ATP binding cassette (ABC) transporters to overcome multidrug resistance to cancer chemotherapy
Utilizing non-coding RNA-mediated regulation of ATP binding cassette (ABC) transporters to overcome multidrug resistance to cancer chemotherapy
Despite significant advances in the development of new anticancer drugs, the emergence of multidrug resistance (MDR) remai...
Tumor-associated macrophage (TAM)-secreted CCL22 confers cisplatin resistance of esophageal squamous cell carcinoma (ESCC) cells via regulating the activity of diacylglycerol kinase α (DGKα)/NOX4 axis
Tumor-associated macrophage (TAM)-secreted CCL22 confers cisplatin resistance of esophageal squamous cell carcinoma (ESCC) cells via regulating the activity of diacylglycerol kinase α (DGKα)/NOX4 axis
Tumor development and malignant progression are constituted of several complex steps that are comprehensively induced or i...
Inhibition of SIRT7 overcomes sorafenib acquired resistance by suppressing ERK1/2 phosphorylation via the DDX3X-mediated NLRP3 inflammasome in hepatocellular carcinoma
Inhibition of SIRT7 overcomes sorafenib acquired resistance by suppressing ERK1/2 phosphorylation via the DDX3X-mediated NLRP3 inflammasome in hepatocellular carcinoma
Available online 17 January 2024, 101054Author links open overlay panel, , , , , , , , , , , , , , , , , , , …Highlights•H...
Dual specific phosphatase 4 suppresses ferroptosis and enhances sorafenib resistance in hepatocellular carcinoma
Dual specific phosphatase 4 suppresses ferroptosis and enhances sorafenib resistance in hepatocellular carcinoma
Hepatocellular carcinoma (HCC), the primary liver malignancy, ranks as the seventh most frequently occurring cancer in the...
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