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Structural Studies of Ion Channels: Achievements, Problems, and Perspectives
Structural Studies of Ion Channels: Achievements, Problems, and Perspectives
The superfamily of membrane proteins known as P-loop channels encompasses potassium, sodium, and calcium channels, as well...
Lipid-Mediated Adaptation of Proteins and Peptides in Cell Membranes
Lipid-Mediated Adaptation of Proteins and Peptides in Cell Membranes
The paper overviews the results of computational studies of the molecular mechanisms underlying the adaptation of model ce...
Alterations of Store-Operated Calcium Entry in Neurodegenerative Pathologies: History, Facts, and Prospects
Alterations of Store-Operated Calcium Entry in Neurodegenerative Pathologies: History, Facts, and Prospects
Neurodegenerative diseases, along with cardiovascular and oncological pathologies, are one of the most acute problems of m...
Mechanisms of Lipid-Mediated Regulation of the Pore-Forming Activity of Antimicrobial Agents: Studies on Planar Lipid Bilayers
Mechanisms of Lipid-Mediated Regulation of the Pore-Forming Activity of Antimicrobial Agents: Studies on Planar Lipid Bilayers
Planar lipid bilayers are unique tools designed for modeling cell membranes and electrophysiological studies of ion channe...
Structure and Functions of the OTOP1 Proton Channel
Structure and Functions of the OTOP1 Proton Channel
OTOP1 belongs to the otopetrin family of membrane proteins that form proton channels in cells of diverse types. In mammals...
Evolutionary Choice between Cholesterol and Ergosterol
Evolutionary Choice between Cholesterol and Ergosterol
Sterol biosynthesis has evolved early in the history of eukaryotes. In most animals, as well as in primitive fungi, the ma...
Membrane-Dependent Reactions of Blood Coagulation: Classical View and State-of-the-Art Concepts
Membrane-Dependent Reactions of Blood Coagulation: Classical View and State-of-the-Art Concepts
The complex mechanism called hemostasis evolved in living organisms to prevent blood loss when a blood vessel is damaged. ...
Cell Membrane Cholesterol and Regulation of Cellular Processes: New and the Same Old Thing
Cell Membrane Cholesterol and Regulation of Cellular Processes: New and the Same Old Thing
Membranes of living cells, or biological membranes, are unique molecular systems in which the functioning of all molecules...
Role of Membrane H+ Transport and Plasmalemma Excitability in Pattern Formation, Long-Distance Transport and Photosynthesis of Characean Algae
Role of Membrane H+ Transport and Plasmalemma Excitability in Pattern Formation, Long-Distance Transport and Photosynthesis of Characean Algae
Illuminated giant cells of Characeae produce alternating areas with H+-pump activity and zones of high H+/OH– conduc...
Influence of Low-Intensive He-Ne Laser Radiation on the Composition and Content of Phospholipids and Sterols in the Callus Tissues of Wheat Тriticum aestivum L.
Influence of Low-Intensive He-Ne Laser Radiation on the Composition and Content of Phospholipids and Sterols in the Callus Tissues of Wheat Тriticum aestivum L.
The effect of He-Ne laser radiation on the composition and content of cell membrane components, namely phospholipids (PL) ...
Physicochemical Features of Thrombin Binding to Platelet Membrane
Physicochemical Features of Thrombin Binding to Platelet Membrane
Thrombin is a key enzyme of the blood coagulation system, which has been actively studied since the beginning of the last ...
Comparative Investigation of the Mechanisms of Calcium Response in Human and Murine Spermatozoa
Comparative Investigation of the Mechanisms of Calcium Response in Human and Murine Spermatozoa
Calcium signaling is a principal method of signal transduction in cells of non-excitable tissues. In both mouse and human ...
Changes in Histone Code Regulation during the Initiation of Paraptosis-Like Death of HEp-2 Tumor Cells by Oxidized Disulfiram Derivatives
Changes in Histone Code Regulation during the Initiation of Paraptosis-Like Death of HEp-2 Tumor Cells by Oxidized Disulfiram Derivatives
Disulfiram (DSF) and its oxidized derivatives (DSFoxy) are currently being investigated as potential anticancer agents. We...
The Effect of 20-Hydroxyecdysone on the Functioning of Isolated Mouse Skeletal Muscle Mitochondria
The Effect of 20-Hydroxyecdysone on the Functioning of Isolated Mouse Skeletal Muscle Mitochondria
In this work we have studied the effect of the phytoecdysteroid 20-hydroxyecdysone (20E) on the functioning of mouse skele...
Electrophysiology of the Danio rerio Heart
Electrophysiology of the Danio rerio Heart
Tropical teleost fish Danio rerio is increasingly used as a model object for electrophysiological studies of human cardiac...
On the Feasibility of Using an Acedan-Based Fluorescent Probe to Monitor Hydrogen Sulfide in Primary Neuronal Cultures
On the Feasibility of Using an Acedan-Based Fluorescent Probe to Monitor Hydrogen Sulfide in Primary Neuronal Cultures
Hydrogen sulfide (H2S), which under physiological conditions exists in cells mainly in the form of the HS– anion, is...
The Mechanism of Calcium-Activated Chloride ANO6 Channel Inhibition by CaCCinh-A01
The Mechanism of Calcium-Activated Chloride ANO6 Channel Inhibition by CaCCinh-A01
Proteins of the anoctamine family (ANO) form calcium-activated chloride channels (CaCC) and phospholipid scramblases. The ...
Analysis of Molecular Mechanisms of Chronic Irradiation Effects on Electrical Signals in Wheat Plants
Analysis of Molecular Mechanisms of Chronic Irradiation Effects on Electrical Signals in Wheat Plants
The effect of ionizing radiation (IR) on plants is mainly realized by altering the status of signaling systems and modifyi...
The Effect of Nicotine Acetylcholine Receptor Ligands on the Adhesive Properties of Murine Bone Marrow Granulocytes in Inflammation
The Effect of Nicotine Acetylcholine Receptor Ligands on the Adhesive Properties of Murine Bone Marrow Granulocytes in Inflammation
Attachment to the vascular endothelium is the first step of the release of mature neutrophil granulocytes from the bone ma...
Corneal Endothelial Cell Volume Regulation Disorders in Keratoconus
Corneal Endothelial Cell Volume Regulation Disorders in Keratoconus
The study of the permeability to water and urea of plasma membranes of endothelial cells of the normal cornea and cornea w...
Energy Barrier of a Monolayer Stalk Formation during Lipid Droplet Fusion
Energy Barrier of a Monolayer Stalk Formation during Lipid Droplet Fusion
Lipid droplets are organelles responsible for the accumulation and breakdown of neutral fats in the human body. Lipid drop...
Organization of the Reserve Pool of Synaptic Vesicles in Nerve Terminals Lacking Protein Liquid Phase Components
Organization of the Reserve Pool of Synaptic Vesicles in Nerve Terminals Lacking Protein Liquid Phase Components
The protein endophilin A, which in the mammalian genome is encoded by three genes, endophilin A1, A2, and A3, regulates th...
Corrections to the Electrical Capacitance of Deformed Lipid Membrane
Corrections to the Electrical Capacitance of Deformed Lipid Membrane
The thickness of the lipid membrane is its substantial characteristics. Usually, the thickness of a lipid bilayer is exper...
α1-Adrenergic Receptors Control the Activity of Sinoatrial Node by Modulating Transmembrane Transport of Chloride Anions
α1-Adrenergic Receptors Control the Activity of Sinoatrial Node by Modulating Transmembrane Transport of Chloride Anions
Norepinephrine (NE), which is released by sympathetic nerve endings, causes an increase in the frequency of spontaneous ac...
The Role of the HL-7 Peptide in the Induction of the Intrinsic Signalling Pathway of Apoptosis in HeLa Cancer Cells
The Role of the HL-7 Peptide in the Induction of the Intrinsic Signalling Pathway of Apoptosis in HeLa Cancer Cells
Anticancer peptides are of interest for cancer treatment. Nowadays, the process of apoptosis is considered a molecular tar...
Spatial Organization of the Components of the Serotonergic System in the Early Mouse Development
Spatial Organization of the Components of the Serotonergic System in the Early Mouse Development
Serotonin is a regulator of early embryonic development and has a complete functional system in preimplantation mammalian ...
Activation of Complement Factor C3/C3b Deposition on the of Endothelial Cell Surface by Histamine As one of the Causes of Endothelium Damage in COVID-19
Activation of Complement Factor C3/C3b Deposition on the of Endothelial Cell Surface by Histamine As one of the Causes of Endothelium Damage in COVID-19
Endothelial damage as a result of complement system activation is one of the causes of thrombotic complications in COVID-1...
Sensors of Intracellular Nucleic Acids Activating STING-Dependent Production of Interferons in Immunocompetent Cells
Sensors of Intracellular Nucleic Acids Activating STING-Dependent Production of Interferons in Immunocompetent Cells
Currently, foreign DNA or RNA sensor proteins, which play an important role in innate immunity, are of great interest as a...
Molecular Model of Norfloxacin Translocation through Yersinia pseudotuberculosis Porin OmpF Channel: Electrophysiological and Molecular Modeling Study
Molecular Model of Norfloxacin Translocation through Yersinia pseudotuberculosis Porin OmpF Channel: Electrophysiological and Molecular Modeling Study
The interaction of the Yersinia pseudotuberculosis porin OmpF (YpOmpF) with the fluoroquinolone antibiotic norfloxacin (Nf...
ATP Causes Contraction of Denervated Skeletal Muscles
ATP Causes Contraction of Denervated Skeletal Muscles
The ability of humoral agonists (and their persistent analogues) to induce contractions of denervated m. soleus and m. ext...
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