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Oral bacteria accelerate pancreatic cancer development in mice
Oral bacteria accelerate pancreatic cancer development in mice
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Faecal microbial transfer and complex carbohydrates mediate protection against COPD
Faecal microbial transfer and complex carbohydrates mediate protection against COPD
Chronic obstructive pulmonary disease (COPD) is most often caused by long-term cigarette smoke (CS) inhalation and include...
Coeliac disease: the paradox of diagnosing a food hypersensitivity disorder with autoantibodies
Coeliac disease: the paradox of diagnosing a food hypersensitivity disorder with autoantibodies
Serum antibodies to the autoantigen transglutaminase 2 (TG2) are increasingly harnessed to diagnose coeliac disease. Diagn...
Standardised training for endoscopic mucosal resection of large non-pedunculated colorectal polyps to reduce recurrence (*STAR-LNPCP study): a multicentre cluster randomised trial
Standardised training for endoscopic mucosal resection of large non-pedunculated colorectal polyps to reduce recurrence (*STAR-LNPCP study): a multicentre cluster randomised trial
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Glucagon-like peptide-1 receptor agonists and risk of major adverse liver outcomes in patients with chronic liver disease and type 2 diabetes
Glucagon-like peptide-1 receptor agonists and risk of major adverse liver outcomes in patients with chronic liver disease and type 2 diabetes
WHAT IS ALREADY KNOWN ON THIS TOPICGlucagon-like peptide-1 receptor (GLP1) agonists might resolve metabolic dysfunction-as...
CD39 deletion in TCR-engineered T cells enhances antitumour immunity
CD39 deletion in TCR-engineered T cells enhances antitumour immunity
Tumour-reactive T cells infiltrating solid tumours are often rendered exhausted, a cell differentiation state characterise...
Is acute necrotising pancreatitis a chronic disease?
Is acute necrotising pancreatitis a chronic disease?
Acute pancreatitis (AP) is a common disease with an annual incidence of 34 (23–49) per 100 000 population.1 Patients with ...
Ferritin--a promising biomarker in MASLD
Ferritin--a promising biomarker in MASLD
Human ferritins are expressed in essentially all cells of the human body. From an evolutionary perspective, human ferritin...
New AI model for neoplasia detection and characterisation in inflammatory bowel disease
New AI model for neoplasia detection and characterisation in inflammatory bowel disease
MessageEndoscopic neoplasia detection in inflammatory bowel disease (IBD) remains challenging. We developed and validated ...
Glucagon-like peptide-1 receptor agonists to treat chronic liver disease: real-world evidence or ambiguity?
Glucagon-like peptide-1 receptor agonists to treat chronic liver disease: real-world evidence or ambiguity?
Chronic liver diseases are prevalent, particularly among patients with type 2 diabetes, who have a higher incidence of met...
Unusual cause of abdominal pain
Unusual cause of abdominal pain
An 18-year-old woman presented with a 4-day history of worsening abdominal pain. Physical examination revealed tenderness ...
Understanding the malignant potential of gastric metaplasia of the oesophagus and its relevance to Barretts oesophagus surveillance: individual-level data analysis
Understanding the malignant potential of gastric metaplasia of the oesophagus and its relevance to Barretts oesophagus surveillance: individual-level data analysis
IntroductionBarrett’s oesophagus (BO) is a precursor lesion for oesophageal adenocarcinoma (OAC) and provides an opportuni...
Fibrosis in IBD: from pathogenesis to therapeutic targets
Fibrosis in IBD: from pathogenesis to therapeutic targets
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Toning down the role of eosinophils in eosinophilic oesophagitis
Toning down the role of eosinophils in eosinophilic oesophagitis
Eosinophilic oesophagitis (EoE) is an immune-mediated disease of uncertain aetiology. The diagnosis of EoE relies on the e...
Antibiotic use and inflammatory bowel disease: number needed to harm? Authors reply
Antibiotic use and inflammatory bowel disease: number needed to harm? Authors reply
We thank Ludvigsson for his interest in our work and for providing additional insights. As noted, our joint works implicat...
Refining definitions of Barretts oesophagus to improve clinical resource utilisation
Refining definitions of Barretts oesophagus to improve clinical resource utilisation
Oesophageal adenocarcinoma (OAC) is a devastating disease with an average 5-year survival of around 15%.1 Moreover, rates ...
Defining gene-lifestyle interactions in inflammatory bowel disease: progress towards understanding disease pathogenesis
Defining gene-lifestyle interactions in inflammatory bowel disease: progress towards understanding disease pathogenesis
Recently, Lopes et al quantified the effect of modifiable lifestyle factors in inflammatory bowel disease (IBD) prevention...
Serum ferritin levels can predict long-term outcomes in patients with metabolic dysfunction-associated steatotic liver disease
Serum ferritin levels can predict long-term outcomes in patients with metabolic dysfunction-associated steatotic liver disease
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Unveiling 8 years of duodenoscope contamination: insights from a retrospective analysis in a large tertiary care hospital
Unveiling 8 years of duodenoscope contamination: insights from a retrospective analysis in a large tertiary care hospital
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MASLD: a systemic metabolic disorder with cardiovascular and malignant complications
MASLD: a systemic metabolic disorder with cardiovascular and malignant complications
Non-alcoholic fatty liver disease (NAFLD) has become the most common cause of chronic liver disease globally and is curren...
ATP citrate lyase (ACLY)-dependent immunometabolism in mucosal T cells drives experimental colitis in vivo
ATP citrate lyase (ACLY)-dependent immunometabolism in mucosal T cells drives experimental colitis in vivo
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Chimeric antigen receptors of HBV envelope proteins inhibit hepatitis B surface antigen secretion
Chimeric antigen receptors of HBV envelope proteins inhibit hepatitis B surface antigen secretion
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Early-life diet and risk of inflammatory bowel disease: a pooled study in two Scandinavian birth cohorts
Early-life diet and risk of inflammatory bowel disease: a pooled study in two Scandinavian birth cohorts
IntroductionIBD, mainly including the subtypes Crohn’s disease (CD) and UC, is a globally rising immune-mediated disease c...
Quantification of circulating HBV RNA expressed from intrahepatic cccDNA in untreated and NUC treated patients with chronic hepatitis B
Quantification of circulating HBV RNA expressed from intrahepatic cccDNA in untreated and NUC treated patients with chronic hepatitis B
WHAT IS ALREADY KNOWN ON THIS TOPICMeasurement of serum hepatitis B virus (HBV) RNA concentration has been proposed has a ...
Beyond a liver-gut focus: the evolution of gastroenterology and hepatology in challenging the obesity and steatotic liver disease paradigm
Beyond a liver-gut focus: the evolution of gastroenterology and hepatology in challenging the obesity and steatotic liver disease paradigm
We read with great interest the paper by Camilleri and El-Omar ‘10 reasons that gastroenterologists and hepatologists shou...
Clinical applications of circulating HBV RNA as a potential surrogate biomarker for intrahepatic cccDNA transcriptional activity
Clinical applications of circulating HBV RNA as a potential surrogate biomarker for intrahepatic cccDNA transcriptional activity
There is a close link between diagnostic and therapeutic approaches. The more precise the biomarker, the more accurately w...
New facet of CARs: HBV-specific CARs as inhibitors of virus morphogenesis and release
New facet of CARs: HBV-specific CARs as inhibitors of virus morphogenesis and release
Although safe and effective vaccines against HBV (hepatitis B virus) are available, there are worldwide more than 2 billio...
Fatal intestinal disease: a case of recurrent lower gastrointestinal bleeding
Fatal intestinal disease: a case of recurrent lower gastrointestinal bleeding
A 69-year-old man was admitted to our hospital with abdominal pain, fever and massive bloody stool for the last 3 days, bu...
ForePass endoscopic bypass device for obesity and insulin resistance--metabolic treatment in a swine model
ForePass endoscopic bypass device for obesity and insulin resistance--metabolic treatment in a swine model
WHAT IS ALREADY KNOWN ON THIS SUBJECTMetabolic surgery (MS) is a highly effective treatment for obesity and type 2 diabete...
10-year follow-up results of the European Achalasia Trial: a multicentre randomised controlled trial comparing pneumatic dilation with laparoscopic Heller myotomy
10-year follow-up results of the European Achalasia Trial: a multicentre randomised controlled trial comparing pneumatic dilation with laparoscopic Heller myotomy
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