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MicroRNA-223 attenuates hepatocarcinogenesis by blocking hypoxia-driven angiogenesis and immunosuppression
MicroRNA-223 attenuates hepatocarcinogenesis by blocking hypoxia-driven angiogenesis and immunosuppression
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Mepolizumab for treatment of adolescents and adults with eosinophilic oesophagitis: a multicentre, randomised, double-blind, placebo-controlled clinical trial
Mepolizumab for treatment of adolescents and adults with eosinophilic oesophagitis: a multicentre, randomised, double-blind, placebo-controlled clinical trial
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Consensus definition of sludge and microlithiasis as a possible cause of pancreatitis
Consensus definition of sludge and microlithiasis as a possible cause of pancreatitis
WHAT IS ALREADY KNOWN ON THIS TOPICIn up to 20% of patients, the aetiology of acute pancreatitis (AP) remains elusive and ...
Psychological symptoms do not discriminate between reflux phenotypes along the organic-functional refractory GERD spectrum
Psychological symptoms do not discriminate between reflux phenotypes along the organic-functional refractory GERD spectrum
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An efficient strategy for evaluating new non-invasive screening tests for colorectal cancer: the guiding principles
An efficient strategy for evaluating new non-invasive screening tests for colorectal cancer: the guiding principles
WHAT IS ALREADY KNOWN ON THIS TOPICIn 2016, a practical guide for evaluation of new non-invasive screening tests for color...
Assessment of the yearly carbon emission of a gastrointestinal endoscopy unit
Assessment of the yearly carbon emission of a gastrointestinal endoscopy unit
MessageDespite ‘green endoscopy’ has meanwhile been regarded as a highly relevant topic, the scientific basis of ongoing d...
BSG guidelines on faecal immunochemical testing: are they 'FIT for purpose?
BSG guidelines on faecal immunochemical testing: are they 'FIT for purpose?
The use of faecal immunochemical testing (FIT) for patients with features of possible colorectal cancer (CRC) has increase...
Multiple inflammatory mechanisms in eosinophilic oesophagitis make it unlikely that single pathway inhibition by monoclonal biological therapies would succeed
Multiple inflammatory mechanisms in eosinophilic oesophagitis make it unlikely that single pathway inhibition by monoclonal biological therapies would succeed
Once regarded as a rare disease, the incidence and prevalence of eosinophilic oesophagitis (EoE) have risen consistently o...
Is HBx protein the X factor in the pathogenesis of IBD?
Is HBx protein the X factor in the pathogenesis of IBD?
The role of viruses in the aetiopathogenesis of inflammatory bowel disease (IBD) has been a topic of conjecture for decade...
Obesity promotes a leaky gut, inflammation and pre-diabetes by lowering gut microbiota that metabolise ethanolamine
Obesity promotes a leaky gut, inflammation and pre-diabetes by lowering gut microbiota that metabolise ethanolamine
Microbiota are a source of low-grade inflammation during obesity and contribute to insulin resistance and poor blood gluco...
New insights into an old paradigm: why IgA accumulates in alcoholic liver disease and what could be its role
New insights into an old paradigm: why IgA accumulates in alcoholic liver disease and what could be its role
Alcoholic liver disease (ALD) is the most prevalent cause of chronic liver disease in western countries with highly morbid...
MicroRNA-223: a key regulator of liver tumour microenvironment
MicroRNA-223: a key regulator of liver tumour microenvironment
Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related deaths worldwide with few effective drug trea...
Bad gut feeling: a case of recurrent abdominal pain in a young man
Bad gut feeling: a case of recurrent abdominal pain in a young man
A Southeast Asian man in his early 20s with no medical history presented with persistent abdominal pain and nausea for 3 w...
Enolase: a metabolic checkpoint behind diverse exhaustion stages of CD8+ T cells in chronic HBV and HCV
Enolase: a metabolic checkpoint behind diverse exhaustion stages of CD8+ T cells in chronic HBV and HCV
Resolving chronic hepatic infections caused by hepatitis B and C viruses (HBV and HCV) could be realised through two prima...
Hepatic pIgR-mediated secretion of IgA limits bacterial translocation and prevents ethanol-induced liver disease in mice
Hepatic pIgR-mediated secretion of IgA limits bacterial translocation and prevents ethanol-induced liver disease in mice
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Mature tertiary lymphoid structures are key niches of tumour-specific immune responses in pancreatic ductal adenocarcinomas
Mature tertiary lymphoid structures are key niches of tumour-specific immune responses in pancreatic ductal adenocarcinomas
AbstractObjective To better understand the immune microenvironment of pancreatic ductal adenocarcinomas (PDACs), here we e...
SARS-CoV-2 Omicron variant infection was associated with higher morbidity in patients with cirrhosis
SARS-CoV-2 Omicron variant infection was associated with higher morbidity in patients with cirrhosis
Dufour et al highlighted that the effect of COVID-19 in patients with cirrhosis is derived from the prevaccination era and...
Drug rediscovery in gastroenterology: from off-label to on-label use of thioguanine in inflammatory bowel disease
Drug rediscovery in gastroenterology: from off-label to on-label use of thioguanine in inflammatory bowel disease
Drug rediscovery refers to the principle of using ‘old’ drugs outside the indications mentioned in the summary of product ...
Response to Mansoor et al: 'epidemiology of inflammatory bowel disease in men with high-risk homosexual activity
Response to Mansoor et al: 'epidemiology of inflammatory bowel disease in men with high-risk homosexual activity
We were interested to read the letter by Mansoor et al, ‘epidemiology of inflammatory bowel disease (IBD) in men with high...
Gut microbiota as non-invasive diagnostic and prognostic biomarkers for natural killer/T-cell lymphoma
Gut microbiota as non-invasive diagnostic and prognostic biomarkers for natural killer/T-cell lymphoma
We read with interest the study by Kartal et al 1 showing that the gut-microbiota-derived biomarkers for disease stratific...
Association between inflammatory bowel disease and Alzheimers disease: multivariable and bidirectional Mendelian randomisation analyses
Association between inflammatory bowel disease and Alzheimers disease: multivariable and bidirectional Mendelian randomisation analyses
We read with interest the study by Zhang et al,1 showing that inflammatory bowel disease (IBD) was associated with increas...
Life cycle assessment of routinely used endoscopic instruments and simple intervention to reduce our environmental impact
Life cycle assessment of routinely used endoscopic instruments and simple intervention to reduce our environmental impact
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SARS-CoV-2 and the liver: clinical and immunological features in chronic liver disease
SARS-CoV-2 and the liver: clinical and immunological features in chronic liver disease
Key messagesClinical features of COVID-19 in CLD patients with CLD and healthy individualsImmunological features of COVID-...
Changes in signalling from faecal neuroactive metabolites following dietary modulation of IBS pain
Changes in signalling from faecal neuroactive metabolites following dietary modulation of IBS pain
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Targeting PPAR-gamma counteracts tumour adaptation to immune-checkpoint blockade in hepatocellular carcinoma
Targeting PPAR-gamma counteracts tumour adaptation to immune-checkpoint blockade in hepatocellular carcinoma
IntroductionImmune-checkpoint blockade (ICB) therapies have transformed the treatment landscapes of solid malignancies inc...
Gut commensal Parabacteroides distasonis alleviates inflammatory arthritis
Gut commensal Parabacteroides distasonis alleviates inflammatory arthritis
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Cell-based cccDNA reporter assay combined with functional genomics identifies YBX1 as HBV cccDNA host factor and antiviral candidate target
Cell-based cccDNA reporter assay combined with functional genomics identifies YBX1 as HBV cccDNA host factor and antiviral candidate target
IntroductionChronic infection by hepatitis B virus (HBV) is a major cause of advanced liver disease and hepatocellular car...
Neuroactive changes in the bowel of patients with IBS on low FODMAP diet: another piece of the puzzle
Neuroactive changes in the bowel of patients with IBS on low FODMAP diet: another piece of the puzzle
The publication of Rome IV saw the introduction of the term ‘disorder of gut brain interaction’ as a replacement for the p...
Cracking the host functional network involved in hepatitis B virus cccDNA biology
Cracking the host functional network involved in hepatitis B virus cccDNA biology
Hepatitis B virus (HBV) causes chronic infection in at least 250 million people worldwide, resulting in approximately 850 ...
Unique tumour microenvironment: when ferroptosis activation boosts ICI of liver cancer
Unique tumour microenvironment: when ferroptosis activation boosts ICI of liver cancer
Immune checkpoint inhibition (ICI) has revolutionised cancer therapy in the past decade including liver cancer. Combined I...
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