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Diet fuelling inflammatory bowel diseases: preclinical and clinical concepts
Diet fuelling inflammatory bowel diseases: preclinical and clinical concepts
IntroductionInflammatory bowel diseases (IBDs) encompass a spectrum of chronic inflammatory disorders in and beyond the gu...
NFATc1 signaling drives chronic ER stress responses to promote NAFLD progression
NFATc1 signaling drives chronic ER stress responses to promote NAFLD progression
IntroductionNon-alcoholic liver disease (NAFLD) is emerging as the leading cause of chronic liver disease with an estimate...
Cigarette smoke promotes colorectal cancer through modulation of gut microbiota and related metabolites
Cigarette smoke promotes colorectal cancer through modulation of gut microbiota and related metabolites
Significance of this studyWhat is already known on this subject?Gut microbiota and their metabolites have critical roles i...
FSTL1 promotes liver fibrosis by reprogramming macrophage function through modulating the intracellular function of PKM2
FSTL1 promotes liver fibrosis by reprogramming macrophage function through modulating the intracellular function of PKM2
Significance of this studyWhat is already known on this subject?Macrophage has been identified as key regulators of the li...
Double-blinded randomised placebo controlled trial of enterosgel (polymethylsiloxane polyhydrate) for the treatment of IBS with diarrhoea (IBS-D)
Double-blinded randomised placebo controlled trial of enterosgel (polymethylsiloxane polyhydrate) for the treatment of IBS with diarrhoea (IBS-D)
WHAT IS ALREADY KNOWN ON THIS TOPICCurrent treatments for irritable bowel syndrome (IBS) focus on symptom control and sati...
Neutrophils prevent rectal bleeding in ulcerative colitis by peptidyl-arginine deiminase-4-dependent immunothrombosis
Neutrophils prevent rectal bleeding in ulcerative colitis by peptidyl-arginine deiminase-4-dependent immunothrombosis
IntroductionEver since the initial therapeutic studies of Truelove and Witts,1 rectal bleeding has been considered as an i...
Activation of innate-adaptive immune machinery by poly(I:C) exposes a therapeutic vulnerability to prevent relapse in stroma-rich colon cancer
Activation of innate-adaptive immune machinery by poly(I:C) exposes a therapeutic vulnerability to prevent relapse in stroma-rich colon cancer
IntroductionColorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide, with around 1.3 million cases d...
Understanding pain in chronic pancreatitis: not yet the end of the story?
Understanding pain in chronic pancreatitis: not yet the end of the story?
In Gut, Olesen et al present the first comprehensive multicentre cross-sectional study of pain in prospectively enrolled c...
The future of drug development for inflammatory bowel disease: the need to ACT (advanced combination treatment)
The future of drug development for inflammatory bowel disease: the need to ACT (advanced combination treatment)
The expanding therapeutic armamentarium available for inflammatory bowel disease (IBD) as well as multiple compounds in cl...
Vessel and tissue recognition during third-space endoscopy using a deep learning algorithm
Vessel and tissue recognition during third-space endoscopy using a deep learning algorithm
What is already known on this topicRecently, artificial intelligence (AI) tools have been developed for clinical decision ...
Nationwide gastric cancer prevention in China, 2021-2035: a decision analysis on effect, affordability and cost-effectiveness optimisation
Nationwide gastric cancer prevention in China, 2021-2035: a decision analysis on effect, affordability and cost-effectiveness optimisation
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Cleara...
Stimulatory MAIT cell antigens reach the circulation and are efficiently metabolised and presented by human liver cells
Stimulatory MAIT cell antigens reach the circulation and are efficiently metabolised and presented by human liver cells
IntroductionMucosal-associated invariant T (MAIT) cells are the most abundant population of innate-like T cells in humans;...
'Fish-eye polypectomy defect: a new sign during endoscopic mucosal resection?
'Fish-eye polypectomy defect: a new sign during endoscopic mucosal resection?
A 75-year-old man was referred for the endoscopic management of an 80 mm large non-pedunculated colorectal polyp (LNPCP) i...
PD-L1 blockade liberates intrinsic antitumourigenic properties of glycolytic macrophages in hepatocellular carcinoma
PD-L1 blockade liberates intrinsic antitumourigenic properties of glycolytic macrophages in hepatocellular carcinoma
IntroductionProgrammed death ligand-1 (PD-L1) is a promising therapeutic target in aggressive cancers.1–4 PD-L1 is chiefly...
SARS-CoV-2 pandemic has impacted on patterns of aetiology for acute pancreatitis and management of gallstone pancreatitis in the UK
SARS-CoV-2 pandemic has impacted on patterns of aetiology for acute pancreatitis and management of gallstone pancreatitis in the UK
We recently published the COVIDPAN study1 and follow-up data2 in Gut, which explored the association between concomitant S...
Tiny contributors to severe obesity inside the gut
Tiny contributors to severe obesity inside the gut
Obesity is a key player in the current global health crisis, acting as a leading risk factor in the main causes of morbidi...
Lack of inflammatory bowel disease flare-up following two-dose BNT162b2 vaccine: a population-based cohort study
Lack of inflammatory bowel disease flare-up following two-dose BNT162b2 vaccine: a population-based cohort study
We read with interest the recent paper by Cannatelli et al 1 describing the adverse events (AEs) following COVID-19 vaccin...
Nomenclature and diagnosis of seronegative coeliac disease and chronic non-coeliac enteropathies in adults: the Paris consensus
Nomenclature and diagnosis of seronegative coeliac disease and chronic non-coeliac enteropathies in adults: the Paris consensus
Table 1 shows the list of aetiologies contemplated in this work. Chronic conditions to consider in the differential diagn...
Reprogramming the spleen into a functioning 'liver in vivo
Reprogramming the spleen into a functioning 'liver in vivo
IntroductionLiver transplantation is the only possible solution for end-stage liver diseases (ESLD) with significant loss ...
Cultivated human intestinal fungus Candida metapsilosis M2006B attenuates colitis by secreting acyclic sesquiterpenoids as FXR agonists
Cultivated human intestinal fungus Candida metapsilosis M2006B attenuates colitis by secreting acyclic sesquiterpenoids as FXR agonists
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Cleara...
Impact of HBsAg and HBcrAg levels on phenotype and function of HBV-specific T cells in patients with chronic hepatitis B virus infection
Impact of HBsAg and HBcrAg levels on phenotype and function of HBV-specific T cells in patients with chronic hepatitis B virus infection
IntroductionHepatitis B virus (HBV) infection remains a major global health problem with approximately 257 million people ...
A novel unconventional T cell population enriched in Crohns disease
A novel unconventional T cell population enriched in Crohns disease
Significance of this studyWhat is already known on this subject?T lymphocytes are known to drive Crohn’s disease (CD) path...
Chemotherapy-induced infiltration of neutrophils promotes pancreatic cancer metastasis via Gas6/AXL signalling axis
Chemotherapy-induced infiltration of neutrophils promotes pancreatic cancer metastasis via Gas6/AXL signalling axis
BackgroundMetastasis is the leading cause of cancer-related death. Pancreatic ductal adenocarcinoma (PDAC) frequently meta...
Seronegative coeliac disease and non-coeliac enteropathies: precision medicine, precision medicine, where are you?
Seronegative coeliac disease and non-coeliac enteropathies: precision medicine, precision medicine, where are you?
In a very recent and welcome article, Schiepatti et al address a challenging field of gastroenterology.1 Whereas the diagn...
HBV antigens quantity: duration and effect on functional cure
HBV antigens quantity: duration and effect on functional cure
HBV is a DNA virus that coevolved with humans.1 Different from many other viruses that are detected only after amplificati...
Third Asia-Pacific consensus recommendations on colorectal cancer screening and postpolypectomy surveillance
Third Asia-Pacific consensus recommendations on colorectal cancer screening and postpolypectomy surveillance
The Asia-Pacific region has the largest number of cases of colorectal cancer (CRC) and one of the highest levels of mortal...
Endoscopic pyloromyotomy for the treatment of severe and refractory gastroparesis: a pilot, randomised, sham-controlled trial
Endoscopic pyloromyotomy for the treatment of severe and refractory gastroparesis: a pilot, randomised, sham-controlled trial
IntroductionGastroparesis (GP) is a gastric motility disorder defined by the presence of upper abdominal symptoms and dela...
Impact of pre-procedural testing on SARS-CoV-2 transmission to endoscopy staff
Impact of pre-procedural testing on SARS-CoV-2 transmission to endoscopy staff
WHAT IS ALREADY KNOWN ON THIS TOPICHOW THIS STUDY MIGHT AFFECT RESEARCH, PRACTICE OR POLICYMessagePre-endoscopy viral real...