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Absence of a pancreatic microbiome in intraductal papillary mucinous neoplasm
Absence of a pancreatic microbiome in intraductal papillary mucinous neoplasm
WHAT IS ALREADY KNOWN ON THIS TOPICHOW THIS STUDY MIGHT AFFECT RESEARCH, PRACTICE OR POLICYIntroductionIntraductal papilla...
Mendelian randomisation analysis reveals the possible causal relationship between infections, microbiota and clinical disease
Mendelian randomisation analysis reveals the possible causal relationship between infections, microbiota and clinical disease
We read with interest the recent report by Nashed et al that described changes in the microbiota caused by viral infection...
New entity of adult ultra-short coeliac disease: the first international cohort and case-control study
New entity of adult ultra-short coeliac disease: the first international cohort and case-control study
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Milk fat globule-epidermal growth factor 8 (MFGE8) prevents intestinal fibrosis
Milk fat globule-epidermal growth factor 8 (MFGE8) prevents intestinal fibrosis
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Postprandial symptoms in disorders of gut-brain interaction and their potential as a treatment target
Postprandial symptoms in disorders of gut-brain interaction and their potential as a treatment target
Postprandial, or meal-related, symptoms, such as abdominal pain, early satiation, fullness or bloating, are often reported...
High-fat diet-induced AKT-palmitoylation in hepatocellular carcinoma: a breakthrough mechanistic investigation
High-fat diet-induced AKT-palmitoylation in hepatocellular carcinoma: a breakthrough mechanistic investigation
Primary liver cancer is the third-leading cause of cancer-related mortality globally, accounting for over 700 000 deaths e...
Prophylactic underwater vessel coagulation for submucosal endoscopy
Prophylactic underwater vessel coagulation for submucosal endoscopy
MessageSubmucosal endoscopy procedures including myotomy and endoresections using dissection knives can be hampered by int...
The use of faecal microbiota transplant as treatment for recurrent or refractory Clostridioides difficile infection and other potential indications: second edition of joint British Society of Gastroenterology (BSG) and Healthcare Infection Society (HIS) guidelines
The use of faecal microbiota transplant as treatment for recurrent or refractory Clostridioides difficile infection and other potential indications: second edition of joint British Society of Gastroenterology (BSG) and Healthcare Infection Society (HIS) guidelines
A robust donor screening programme is an essential part of FMT services to ensure safety for FMT recipients. Donor recruit...
Rare complication of peptic ulcer disease
Rare complication of peptic ulcer disease
A 79-year-old man was brought to the emergency department following a 2-week history of epigastric discomfort and a 4-day ...
Novel transcriptomic panel identifies histologically active eosinophilic oesophagitis
Novel transcriptomic panel identifies histologically active eosinophilic oesophagitis
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDSThis study introduces the Histologically Active EoE Diagnostic Pane...
Proton pump inhibitors alter gut microbiota by promoting oral microbiota translocation: a prospective interventional study
Proton pump inhibitors alter gut microbiota by promoting oral microbiota translocation: a prospective interventional study
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Compared to histamine-2 receptor antagonist, proton pump inhibitor induces stronger oral-to-gut microbial transmission and gut microbiome alterations: a randomised controlled trial
Compared to histamine-2 receptor antagonist, proton pump inhibitor induces stronger oral-to-gut microbial transmission and gut microbiome alterations: a randomised controlled trial
IntroductionGastric acid suppressants, such as proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2RAs),...
Temporal trend of mortality in patients with cirrhosis with primary biliary cholangitis and primary sclerosing cholangitis during the COVID-19 pandemic
Temporal trend of mortality in patients with cirrhosis with primary biliary cholangitis and primary sclerosing cholangitis during the COVID-19 pandemic
We read with interest the study by Ampuero et al 1 on the vulnerability of primary biliary cholangitis (PBC) patients to S...
Clarithromycin-containing triple therapy for Helicobacter pylori eradication is inducing increased long-term resistant bacteria communities in the gut
Clarithromycin-containing triple therapy for Helicobacter pylori eradication is inducing increased long-term resistant bacteria communities in the gut
The current European guidelines (Maastricht VI/Florence consensus report) on the management of Helicobacter pylori infecti...
It is in the matrix: a molecular clue to fibro-stenotic Crohns disease
It is in the matrix: a molecular clue to fibro-stenotic Crohns disease
Stricturing Crohn’s disease (CD), a consequence of fibrosis occurring during chronic unresolved gut inflammation, is a com...
B and T cell responses to the BNT162b2 COVID-19 mRNA vaccine are not impaired in germ-free or antibiotic-treated mice
B and T cell responses to the BNT162b2 COVID-19 mRNA vaccine are not impaired in germ-free or antibiotic-treated mice
As reviewed by us recently,1 an increasing number of studies suggest that the gut microbiota is an important regulator of ...
HBV integrations reshaping genomic structures promote hepatocellular carcinoma
HBV integrations reshaping genomic structures promote hepatocellular carcinoma
ResultsCommon genomic aberrations and HBV integrations in HCCWith WGS, we analysed the tumour DNA samples derived from HCC...
High-fat diet promotes liver tumorigenesis via palmitoylation and activation of AKT
High-fat diet promotes liver tumorigenesis via palmitoylation and activation of AKT
IntroductionDiet not only provides nutrition and building blocks for the uncontrolled growth of tumour cells, but also pro...
Clinical, experimental and pathophysiological effects of Yaq-001: a non-absorbable, gut-restricted adsorbent in models and patients with cirrhosis
Clinical, experimental and pathophysiological effects of Yaq-001: a non-absorbable, gut-restricted adsorbent in models and patients with cirrhosis
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Basal levels of microbiota-driven subclinical inflammation are associated with anastomotic leak in patients with colorectal cancer
Basal levels of microbiota-driven subclinical inflammation are associated with anastomotic leak in patients with colorectal cancer
In our recent publication in Gut,1 we showed that preoperative gut microbiota was causally linked to the development of an...
Genetic and transcriptomic landscape of colonic diverticulosis
Genetic and transcriptomic landscape of colonic diverticulosis
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Association of healthy lifestyle behaviours with incident irritable bowel syndrome: a large population-based prospective cohort study
Association of healthy lifestyle behaviours with incident irritable bowel syndrome: a large population-based prospective cohort study
IntroductionIrritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterised by recurrent abdominal ...
PNPLA3 fatty liver allele was fixed in Neanderthals and segregates neutrally in humans
PNPLA3 fatty liver allele was fixed in Neanderthals and segregates neutrally in humans
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Rare cause of obstructive jaundice
Rare cause of obstructive jaundice
IntroductionAn 85-year-old woman, with a high-grade fever (40°C) and abdominal pain, was referred to our hospital. Blood e...
Serum biomarker signature is predictive of the risk of hepatocellular cancer in patients with cirrhosis
Serum biomarker signature is predictive of the risk of hepatocellular cancer in patients with cirrhosis
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDSThis longitudinal phase III biomarker validation study measured the...
Antiobesity interventions: options, evidence and value
Antiobesity interventions: options, evidence and value
Adults with obesity have more choices than ever before of therapies that reduce body mass index (BMI) and consequently imp...
Enhancing the opportunities for cholangiocarcinoma precision therapy
Enhancing the opportunities for cholangiocarcinoma precision therapy
Cholangiocarcinoma (CCA), the second most prevalent liver cancer, encompasses a heterogenous group of bile duct malignanci...
Targeting metalloproteases is a promising strategy to enhance immunotherapy responses by overcoming immune exclusion in hepatocellular carcinoma
Targeting metalloproteases is a promising strategy to enhance immunotherapy responses by overcoming immune exclusion in hepatocellular carcinoma
The advent of immune checkpoint inhibitors, particularly monoclonal antibodies (mAbs) that target the programmed cell deat...
National Institute for Health and Care Excellence (NICE) guidance on monitoring and management of Barretts oesophagus and stage I oesophageal adenocarcinoma
National Institute for Health and Care Excellence (NICE) guidance on monitoring and management of Barretts oesophagus and stage I oesophageal adenocarcinoma
Executive summaryBarrett’s oesophagus is defined as the adaptive metaplastic change of the oesophageal mucosa from the nat...
Impact of power consumption and power saving for GI endoscopy (power on study) on reducing CO2 emissions
Impact of power consumption and power saving for GI endoscopy (power on study) on reducing CO2 emissions
MessageEndoscopy is among the top three contributors to CO2 emissions in hospitals, with power consumption being a key fac...
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