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Protective potentials of extracted compound SILIBININ from milk thistle on type-2 diabetes mellitus and diesel exhaust particle (DEP) toxicity in experimental rats
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Endothelial cells under disturbed flow release extracellular vesicles to promote inflammatory polarization of macrophages and accelerate atherosclerosis
Endothelial cells under disturbed flow release extracellular vesicles to promote inflammatory polarization of macrophages and accelerate atherosclerosis
Extracellular vesicles (EVs) derived from endothelial cells (ECs) are increasingly recognized for their role in the initia...
Genome sequences of four Ixodes species expands understanding of tick evolution
Genome sequences of four Ixodes species expands understanding of tick evolution
Ticks, hematophagous Acari, pose a significant threat by transmitting various pathogens to their vertebrate hosts during f...
Characteristics of transcriptome and chromatin accessibility in the peripheral blood after acute hypoxia exposure
Characteristics of transcriptome and chromatin accessibility in the peripheral blood after acute hypoxia exposure
Human responses and acclimation to the environmental stresses of high altitude and low oxygen are multifaceted and regulat...
Co-isolation of human donor eye cells and development of oncogene-mutated melanocytes to study uveal melanoma
Co-isolation of human donor eye cells and development of oncogene-mutated melanocytes to study uveal melanoma
Uveal melanoma (UM) is the most common intraocular tumor in adults, arises either de novo from normal choroidal melanocyte...
Unveiling cell-type-specific microRNA networks through alternative polyadenylation in glioblastoma
Unveiling cell-type-specific microRNA networks through alternative polyadenylation in glioblastoma
Glioblastoma multiforme (GBM) is characterized by its cellular complexity, with a microenvironment consisting of diverse c...
Recent Advances in Green Multi-Component Reactions for Heterocyclic Compound Construction
Multi-component reactions (MCRs) are processes in which three or more reactants are introduced in one pot to deliver final...
Recent Progress on the Electro-Organic Synthesis for the 1,2-Difunctionalization of Alkenes
Recent years have witnessed significant achievements in electro-organic chemistry, particularly in the difunctionalization...
An efficient direct electrolysis method for the synthesis of 1,1,1,3,3,3-hexafluoroisopropyxy substituted imidazo[1,2-a]pyridines
Electrochemical oxidative cross-dehydrogenative-coupling (CDC) is an ideal strategy to develop C3-alkoxylation of imidazo[...
Disulfide Mediated Ruthenium Catalyzed Direct C-H Thiolation in Benzoxazinone Systems: Selective Synthesis of ortho-Thiolated 2- Arylbenzoxazinones
2-Arylbenzoxazinone undergoes direct ortho-C-H thiolation by using diaryl disulfide in presence of Ru(II)-phosphine cataly...
FeCl3-Catalyzed Oxidative Diselenylation of Pyrrole-tethered Indoles
A mild and efficient FeCl3-catalyzed oxidative diselenylation of pyrrole-tethered indoles has been reached by using RSeSeR...
Bromide-promoted cascade annulation of isocyanobiaryls with aldehydes through photoredox catalysis
Herein, we report a cascade annulation of readily available isocyanobiaryls with simple aldehydes via photoredox catalysis...
Atmospheric Oxygen Mediated Oxidation Coupling of Primary and Secondary Alcohols: Synthesis of Pyrazolo[1,5-a]pyrimidines
An atmospheric oxygen-mediated oxidative coupling of primary and secondary alcohols for the synthesis of nitrogen-containi...
Recursive seed amplification detects distinct α-synuclein strains in cerebrospinal fluid of patients with Parkinson’s disease
Recursive seed amplification detects distinct α-synuclein strains in cerebrospinal fluid of patients with Parkinson’s disease
Parkinson’s disease (PD) is a heterogeneous neurodegenerative disorder with a wide range of clinical phenotypes. Pat...
A novel case of glial transdifferentiation in renal medullary carcinoma brain metastasis
A novel case of glial transdifferentiation in renal medullary carcinoma brain metastasis
Renal medullary carcinoma is a rare undifferentiated tumor of the kidney associated with sickle cell trait and characteriz...
Distinct subcellular localization of tau and alpha-synuclein in lewy body disease
Distinct subcellular localization of tau and alpha-synuclein in lewy body disease
Lewy bodies and neurofibrillary tangles, composed of α-synuclein (α-syn) and tau, respectively, often are found ...
Ultrabright contrast agents with synergistic Raman enhancements for precise intraoperative imaging and photothermal ablation of orthotopic tumor models
Ultrabright contrast agents with synergistic Raman enhancements for precise intraoperative imaging and photothermal ablation of orthotopic tumor models
Intraoperative imaging is critical for achieving precise cancer resection. Among available techniques, Raman spectral imag...
Recent advances in self-targeting natural product-based nanomedicines
Recent advances in self-targeting natural product-based nanomedicines
Natural products, recognized for their potential in disease prevention and treatment, have been integrated with advanced n...
Hydrogel loaded with cerium-manganese nanoparticles and nerve growth factor enhances spinal cord injury repair by modulating immune microenvironment and promoting neuronal regeneration
Hydrogel loaded with cerium-manganese nanoparticles and nerve growth factor enhances spinal cord injury repair by modulating immune microenvironment and promoting neuronal regeneration
Spinal cord injury (SCI) treatment remains a formidable challenge, as current therapeutic approaches provide only marginal...
Maternal exposure to fullerenols impairs placental development in mice by inhibiting estriol synthesis and reducing ERα
Maternal exposure to fullerenols impairs placental development in mice by inhibiting estriol synthesis and reducing ERα
Fullerenols, a water-soluble polyhydroxy derivative of fullerene, hold promise in medical and materials science due to the...
Rational design of a triple-type HPV53/56/66 vaccine with one preferable base particle incorporating two identified immunodominant sites
Rational design of a triple-type HPV53/56/66 vaccine with one preferable base particle incorporating two identified immunodominant sites
The numerous high-risk carcinogenic types of human papillomavirus (HR-HPV) that lack vaccine protection underscore the urg...
Cross-coupling reaction of cyclic quaternary ammonium salts with arylzinc reagents, arylboron reagents, and silylboronate
The nickel-catalyzed reaction of benzocyclic quaternary ammonium salts with arylzinc reagents or arylboron reagents afford...
Unexpected amine-triggered skeletal modification of fascaplysin and its derivatives: a rapid access to δ, γ-biscarbolines
An unsuccessful attempt to directly construct alkaloid iheyamine A from fascaplysin framework resulted in the discovery of...
Ag(I)-Promoted fragment coupling of peptide thioamides
Despite advances in solid phase peptide synthesis and peptide ligation, challenges remain in the assembly of polypeptides ...
Fish as environmental sentinels for metal contaminants of human health concern in the Lower Mississippi River Basin
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Maraviroc/cisplatin combination inhibits gastric cancer tumoroid growth and improves mice survival
Maraviroc/cisplatin combination inhibits gastric cancer tumoroid growth and improves mice survival
Gastric cancer (GC) is a significant cancer-related cause of death worldwide. GC’s most used chemotherapeutic regime...
Alternative splicing landscape in mouse skeletal muscle and adipose tissue: Effects of intermittent fasting and exercise
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Biofunctionalized patterned platform as microarray biochip to supervise delivery and expression of pDNA nanolipoplexes in stem cells via mechanotransduction
Biofunctionalized patterned platform as microarray biochip to supervise delivery and expression of pDNA nanolipoplexes in stem cells via mechanotransduction
Biochips are widely applied to manipulate the geometrical morphology of stem cells in recent years. Patterned antenna-like...
Therapeutic delivery of oxygen using artificial oxygen carriers demonstrates the possibility of treating a wide range of diseases
Therapeutic delivery of oxygen using artificial oxygen carriers demonstrates the possibility of treating a wide range of diseases
Artificial oxygen carriers have emerged as potential substitutes for red blood cells in situations of major blood loss, in...
I2-Catalyzed Benzylation of NH-Sulfoximines with Diarylme-thanes and Al-kylarenes
A practical transition metal-free approach for the selective benzylation of NH-sulfoximines has been disclosed by using si...
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