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Enhancing access to treatment for Gaucher disease in India: The need for indigenous manufacturing
Enhancing access to treatment for Gaucher disease in India: The need for indigenous manufacturing
Gaucher disease (GD) is a prevalent lysosomal storage disorder (LSD) that significantly impacts individuals’ lives. ...
Spinal muscular atrophy: Molecular mechanism of pathogenesis, diagnosis, therapeutics, and clinical trials in the Indian context
Spinal muscular atrophy: Molecular mechanism of pathogenesis, diagnosis, therapeutics, and clinical trials in the Indian context
Spinal muscular atrophy (SMA) is a neuromuscular, rare genetic disorder caused due to loss-of-function mutations in the su...
Recent developments in gene therapy research in India
Recent developments in gene therapy research in India
Inherited genetic disorders are progressive in nature and lead to organ dysfunction or death in severe cases. At present, ...
NIR-IIb fluorescence antiangiogenesis copper nano-reaper for enhanced synergistic cancer therapy
NIR-IIb fluorescence antiangiogenesis copper nano-reaper for enhanced synergistic cancer therapy
The formation of blood vessel system under a relatively higher Cu2+ ion level is an indispensable precondition for tumor p...
Link between organic nanovescicles from vegetable kingdom and human cell physiology: intracellular calcium signalling
Link between organic nanovescicles from vegetable kingdom and human cell physiology: intracellular calcium signalling
Plant-derived nanovesicles (PDNVs) are a novelty in medical and agrifood environments, with several studies exploring thei...
The impact of apelin-13 on cisplatin-induced endocrine pancreas damage in rats: an in vivo study
The impact of apelin-13 on cisplatin-induced endocrine pancreas damage in rats: an in vivo study
Apelin-13 is a peptide hormone that regulates pancreatic endocrine functions, and its benefits on the endocrine pancreas a...
Genome-wide comparative methylation analysis reveals the fate of germ stem cells after surrogate production in teleost
Genome-wide comparative methylation analysis reveals the fate of germ stem cells after surrogate production in teleost
Surrogate production by germline stem cell transplantation is a powerful method to produce donor-derived gametes via a hos...
A combination of conserved and diverged responses underlies Theobroma cacao’s defense response to Phytophthora palmivora
A combination of conserved and diverged responses underlies Theobroma cacao’s defense response to Phytophthora palmivora
Plants have complex and dynamic immune systems that have evolved to resist pathogens. Humans have worked to enhance these ...
Understanding pathophysiology of GNE myopathy and current progress towards drug development
Understanding pathophysiology of GNE myopathy and current progress towards drug development
GNE myopathy is a rare genetic neuromuscular disease that is caused due to mutations in the GNE gene responsible for siali...
Orphan drug development: Challenges, regulation, and success stories
Orphan drug development: Challenges, regulation, and success stories
Rare diseases, also known as orphan diseases, are diseases with low occurrence in the population. Developing orphan drugs ...
mRNA biotherapeutics landscape for rare genetic disorders
mRNA biotherapeutics landscape for rare genetic disorders
The medical emergency of COVID-19 brought to the forefront mRNA vaccine technology where the mRNA vaccine candidates mRNA-...
Rare genetic disorders in India: Current status, challenges, and CRISPR-based therapy
Rare genetic disorders in India: Current status, challenges, and CRISPR-based therapy
Rare genetic diseases are a group of life-threatening disorders affecting significant populations worldwide and p...
Rare genetic diseases in India: Steps toward a nationwide mission program
Rare genetic diseases in India: Steps toward a nationwide mission program
Rare genetic diseases are rare by themselves with prevalence of 1 in 25,000, but collectively they are a significant cause...
Decoding the mitochondria without a code: mechanistic insights into mitochondrial DNA depletion syndromes
Decoding the mitochondria without a code: mechanistic insights into mitochondrial DNA depletion syndromes
Mitochondrial DNA depletion syndromes (MDS) encompass a wide spectrum of rare genetic disorders caused by severe reduction...
Recent advances in two-dimensional nanomaterials for sustainable wearable electronic devices
Recent advances in two-dimensional nanomaterials for sustainable wearable electronic devices
The widespread adoption of smart terminals has significantly boosted the market potential for wearable electronic devices....
ADARs regulate cuticle collagen expression and promote survival to pathogen infection
ADARs regulate cuticle collagen expression and promote survival to pathogen infection
In all organisms, the innate immune system defends against pathogens through basal expression of molecules that provide cr...
Study of Heavy Atom Influence on Poly-halogenated Compounds using DP4/MM-DP4+/DP4+: Insights and Trends
Nuclear Magnetic Resonance (NMR) spectroscopy complemented by Density Functional Theory (DFT) calculations is a crucial to...
Facile Friedel-Crafts alkylation of arenes under solvent-free conditions
The Friedel-Crafts alkylation of arenes is an important part of the electrophilic aromatic substitution reactions. However...
Correction to: Mild traumatic brain injury induces microvascular injury and accelerates Alzheimer-like pathogenesis in mice
Correction to: Mild traumatic brain injury induces microvascular injury and accelerates Alzheimer-like pathogenesis in mice
†Yingxi Wu and Haijian Wu contributed equally.Center for Neurodegeneration and Regeneration, Zilkha Neurogenetic Institute...
A human stomach cell type transcriptome atlas
A human stomach cell type transcriptome atlas
The identification of cell type-specific genes and their modification under different conditions is central to our underst...