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Targeted lipid nanoparticles distributed in hydrogel treat osteoarthritis by modulating cholesterol metabolism and promoting endogenous cartilage regeneration
Targeted lipid nanoparticles distributed in hydrogel treat osteoarthritis by modulating cholesterol metabolism and promoting endogenous cartilage regeneration
Osteoarthritis (OA) is the most common disease in aging joints and has characteristics of cartilage destruction and inflam...
Resistant starch grafted cerium-sulfasalazine infinite coordination polymers synergistically remold intestinal metabolic microenvironment for inflammatory bowel disease therapy
Resistant starch grafted cerium-sulfasalazine infinite coordination polymers synergistically remold intestinal metabolic microenvironment for inflammatory bowel disease therapy
Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease which is closely related with the overproduced reac...
Gene editing tool-loaded biomimetic cationic vesicles with highly efficient bacterial internalization for in vivo eradication of pathogens
Gene editing tool-loaded biomimetic cationic vesicles with highly efficient bacterial internalization for in vivo eradication of pathogens
In the post-COVID-19 era, drug-resistant bacterial infections emerge as one of major death causes, where multidrug-resista...
Sarcomatous transformation of IDH-mutant astrocytoma matching to methylation class oligosarcoma following embolization, a case report
Sarcomatous transformation of IDH-mutant astrocytoma matching to methylation class oligosarcoma following embolization, a case report
The mesenchymal transformations of infiltrating gliomas are uncommon events. This is particularly true of IDH-mutant astro...
pTau pathology in the retina of TAU58 mice: association with ganglion cell degeneration and implications on seeding and propagation of pTau from human brain lysates
pTau pathology in the retina of TAU58 mice: association with ganglion cell degeneration and implications on seeding and propagation of pTau from human brain lysates
The accumulation of abnormal phosphorylated Tau protein (pTau) in neurons of the brain is a pathological hallmark of Alzhe...
BCKDK loss impairs mitochondrial Complex I activity and drives alpha-synuclein aggregation in models of Parkinson’s disease
BCKDK loss impairs mitochondrial Complex I activity and drives alpha-synuclein aggregation in models of Parkinson’s disease
Mitochondrial dysfunction and α-synuclein (αSyn) aggregation are key contributors to Parkinson’s Disease (...
A snapshot of cancer in Chile II: an update on research, strategies and analytical frameworks for equity, innovation and national development
A snapshot of cancer in Chile II: an update on research, strategies and analytical frameworks for equity, innovation and national development
Chile has achieved developed nation status and boasts a life expectancy of 81 + years; however, the healthcare...
Analysis of downstream targets of PAX6 and LHX2, fundamental regulators of the developing mammalian neocortex
Analysis of downstream targets of PAX6 and LHX2, fundamental regulators of the developing mammalian neocortex
The transcription factors PAX6 and LHX2 play fundamental roles in mammalian cerebral cortical development. Loss of either ...
Glutamate metabolism disruption in Johanson–Blizzard syndrome: Insights from C. elegans ubr-1 model
Glutamate metabolism disruption in Johanson–Blizzard syndrome: Insights from C. elegans ubr-1 model
The Johanson–Blizzard syndrome (JBS) is a complex autosomal recessive disorder that manifests through a spectrum of ...
Comparable Short Term Outcomes Among Patients with Newly Diagnosed Acute Myeloid Leukemia with or without Myelodysplasia Related Gene Mutations Treated with Azacytidine-Venetoclax: Observations from a Single Center Retrospective Cohort
Comparable Short Term Outcomes Among Patients with Newly Diagnosed Acute Myeloid Leukemia with or without Myelodysplasia Related Gene Mutations Treated with Azacytidine-Venetoclax: Observations from a Single Center Retrospective Cohort
Acute Myeloid Leukemia (AML) is a heterogeneous hematologic malignancy, and up to 50% of cases are classified as cytogenet...
Protective effects of adipose-derived stem cells against testicular injury induced after ischemia–reperfusion by regulating autophagy
Protective effects of adipose-derived stem cells against testicular injury induced after ischemia–reperfusion by regulating autophagy
The damaged organ may experience severe pathological alterations as a result of tissue ischemia–reperfusion (I/R). T...
Dietary pentadecanoic acid supplementation at weaning in essential fatty acid-deficient rats shed light on the new family of odd-chain n-8 PUFAs
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The selenium-assisted copper-catalyzed synthesis of phosphoramide from secondary phosphine oxide involves the construction of N-P bonds
In this study, phosphoramide compounds were successfully synthesized via a series of reaction transformations from P(O)H c...
Catalyst-Free Coupling of Peroxypyrroloindolenines with Amines to Afford Stable Peroxyindolenines
Here we report a highly efficient method for coupling of peroxypyrroloindolenines with amines under catalyst-free conditio...
Biobased ionic liquid from natural α-hydroxy acid as halide-free organocatalyst for cycloaddition of CO2 to epoxid
The cycloaddition of CO2 to epoxides (CCE) reactions produced valuable cyclic carbonates useful in electrolytes of lithium...
Palladium–Catalyzed α-Arylation of Sulfoxonium Ylides with Aryl Fluorosulfates
A variety of α-arylated sulfoxonium ylides could be facilely synthesized in modest to high yields through an α-arylation o...
6H-Indolo-[2,3-b]-Quinoxaline derivatives as promising bifunctional SHP1 inhibitors
The dysfunction in the SHP1 can cause cancers and many diseases, so it is of great significance to develop novel small mol...
Copper/Iron Controlled Regioselective 1,2-Carboazidation of 1,3-Dienes with Acetonitrile and Azidotrimethylsilane
The azidocyanation and diazidation were carried out on 1,3-dienes compounds, using TMSN3 as the azide source and MeCN as t...
Recent advances in the reaction of isatin-derived MBH carbonates, synthesis of spiro-oxindoles
As one of the main fragments in medical drugs, spirooxindole has received considerable attention from organic and medicina...
1,4,5-Trisubstituted-1,2,3-Triazoles: An Unconventional Class of Ribonuclease A Inhibitors
1,4,5-Trisubstituted-1,2,3-triazoles (1,4,5-TTs) constitute a special class of functionalized triazoles. This paper report...
Aluminum-Catalyzed Anti-Markovnikov Hydroamination of Aromatic Alkenes with Aromatic Amines
Herein, we report a novel Al compound supported by a NacNac ligand that facilitates the anti-Markovnikov hydroamination of...
ESIPT fluorescence turn-on sensors for detection of short chain inorganic polyphosphate in water
We introduce two water-soluble excited state intramolecular proton transfer (ESIPT) based fluorescent turn-on probes respo...
Development of Urea-Bridged Cyclic Dominant Negative Pneumococcus Competence-Stimulating Peptide Analogs
Cyclization is a widely used approach to exert conformational restraint on linear peptide sequences. Herein, urea bridge c...
Photocatalytic E→Z isomerization of gem-bromofluoroalkenes: Stereospecific synthesis of β-fluorostyrene derivatives
Stereoselective synthesis of β-fluorostyrene derivatives has been developed. Selective isomerization of gem-bromofluoroalk...
Synthesis of pyrano[3,2-c]chromene-2,5-diones from 4-hydroxycoumarins and aminocrotonates under solvent-free conditions
A one-pot new approach was developed for the construction of pyrano[3,2-c]chromene-2,5-diones by reacting 4-hydroxycoumari...
Randomized, multicenter, active-controlled open-label study of NPC-25, zinc histidine hydrate, (non-inferiority to NOBELZIN™, zinc acetate dihydrate) for patients with hypozincemia
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BDNF augmentation reverses cranial radiation therapy-induced cognitive decline and neurodegenerative consequences
BDNF augmentation reverses cranial radiation therapy-induced cognitive decline and neurodegenerative consequences
Cranial radiation therapy (RT) for brain cancers is often associated with the development of radiation-induced cognitive d...
NOX proteins and ROS generation: role in invadopodia formation and cancer cell invasion
NOX proteins and ROS generation: role in invadopodia formation and cancer cell invasion
NADPH oxidases (NOX) are membrane-bound proteins involved in the localized generation of reactive oxygen species (ROS) at ...
Are we cultivating the perfect storm for a human avian influenza pandemic?
Are we cultivating the perfect storm for a human avian influenza pandemic?
The emergence of highly pathogenic avian influenza (HPAI) A H5N1 virus in dairy cattle marks a troubling new chapter in th...
Lack of canonical activities of connexins in highly aggressive human prostate cancer cells
Lack of canonical activities of connexins in highly aggressive human prostate cancer cells
Connexins (Cxs) have the ability to form channels that allow the exchange of ions/metabolites between adjacent cells (gap ...
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