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A new treatment for sarcoma extracted from combination of miRNA deregulation and gene association rules
A new treatment for sarcoma extracted from combination of miRNA deregulation and gene association rules
Sarcomas are a group of heterogeneous mesodermic rare tumors with high incidence in children, reaching up...
CNTNAP2 intracellular domain (CICD) generated by γ-secretase cleavage improves autism-related behaviors
CNTNAP2 intracellular domain (CICD) generated by γ-secretase cleavage improves autism-related behaviors
As the most prevalent neurodevelopmental disorders in children, autism spectrum disorders (ASD) are characterized by defic...
Adult-born neurons in critical period maintain hippocampal seizures via local aberrant excitatory circuits
Adult-born neurons in critical period maintain hippocampal seizures via local aberrant excitatory circuits
Temporal lobe epilepsy (TLE), one common type of medically refractory epilepsy, is accompanied with altered adult-born den...
Metabolic alterations upon SARS-CoV-2 infection and potential therapeutic targets against coronavirus infection
Metabolic alterations upon SARS-CoV-2 infection and potential therapeutic targets against coronavirus infection
The coronavirus disease 2019 (COVID-19) caused by coronavirus SARS-CoV-2 infection has become a global pandemic due to the...
Inflammation and aging: signaling pathways and intervention therapies
Inflammation and aging: signaling pathways and intervention therapies
Aging is characterized by systemic chronic inflammation, which is accompanied by cellular senescence, immunosenescence, or...
Neutralizing antibodies against SARS-CoV-2 virus after vaccination in patients with neurofibromatosis type 1
Neutralizing antibodies against SARS-CoV-2 virus after vaccination in patients with neurofibromatosis type 1
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has triggered a COVID-19 pandemic that h...
Murine studies and expressional analyses of human cardiac pericytes reveal novel trajectories of SARS-CoV-2 Spike protein-induced microvascular damage
Murine studies and expressional analyses of human cardiac pericytes reveal novel trajectories of SARS-CoV-2 Spike protein-induced microvascular damage
The Coronavirus disease 2019 (COVID-19) pandemic has caused over 670 million cases and 6.7 million deaths...
Organoid-based single-cell spatiotemporal gene expression landscape of human embryonic development and hematopoiesis
Organoid-based single-cell spatiotemporal gene expression landscape of human embryonic development and hematopoiesis
a Overall study design. Figure generated by BioRender. Human embryonic organoids (HEMOs) at D8, D15, and D18 were harveste...
RPS15 interacted with IGF2BP1 to promote esophageal squamous cell carcinoma development via recognizing m6A modification
RPS15 interacted with IGF2BP1 to promote esophageal squamous cell carcinoma development via recognizing m6A modification
Increased rates of ribosome biogenesis have been recognized as hallmarks of many cancers and are associated with poor prog...
Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies
Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies
The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major public health burden worldwide. The m...
Synaptic dysfunction in Down syndrome: an emerging role for circulating β2-microglobulin
Synaptic dysfunction in Down syndrome: an emerging role for circulating β2-microglobulin
Recent research by Gao et al. published in Cell proposes that circulating β2-microglobulin impairs synapt...
Nuclear AhR and membranous PD-L1 in predicting response of non-small cell lung cancer to PD-1 blockade
Nuclear AhR and membranous PD-L1 in predicting response of non-small cell lung cancer to PD-1 blockade
Programmed cell death 1 ligand 1 (PD-L1) has been used as a biomarker for immune checkpoint inhibitors (I...
Molecular mechanisms underlying the high mortality of hypervirulent Klebsiella pneumoniae and its effective therapy development
Molecular mechanisms underlying the high mortality of hypervirulent Klebsiella pneumoniae and its effective therapy development
Klebsiella pneumoniae (Kp) has become the most important bacterial pathogen causing high mortality rates ...
Biomarker and genomic analyses reveal molecular signatures of non-cardioembolic ischemic stroke
Biomarker and genomic analyses reveal molecular signatures of non-cardioembolic ischemic stroke
Acute ischemic stroke (AIS) is a major cause of disability and mortality worldwide. Non-cardioembolic ischemic stroke (NCI...
CD5: from antiquated T cell marker to immunotherapy’s new hope
CD5: from antiquated T cell marker to immunotherapy’s new hope
In a recent study published in Science, He et al. investigated the role of CD5 on dendritic cells (DCs) i...
The blood–brain barrier: structure, regulation, and drug delivery
The blood–brain barrier: structure, regulation, and drug delivery
Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous system (CNS) from toxins an...
Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome
Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome
Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder in sleep in which the airways narrow or collapse du...
3-Hydroxybutyrate ameliorates insulin resistance by inhibiting PPARγ Ser273 phosphorylation in type 2 diabetic mice
3-Hydroxybutyrate ameliorates insulin resistance by inhibiting PPARγ Ser273 phosphorylation in type 2 diabetic mice
3-Hydroxybutyrate (3HB) is a small ketone body molecule produced endogenously by the body in the liver. Previous studies h...
Correction To: POD Nanozyme optimized by charge separation engineering for light/pH activated bacteria catalytic/photodynamic therapy
Correction To: POD Nanozyme optimized by charge separation engineering for light/pH activated bacteria catalytic/photodynamic therapy
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Correction To: Intranasal booster using an Omicron vaccine confers broad mucosal and systemic immunity against SARS-CoV-2 variants
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Enhancement of SARS-CoV-2 vaccine-induced immunity by a Toll-like receptor 7 agonist adjuvant
Enhancement of SARS-CoV-2 vaccine-induced immunity by a Toll-like receptor 7 agonist adjuvant
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped positive-sense single-strand...
Inside-out assembly of viral antigens for the enhanced vaccination
Inside-out assembly of viral antigens for the enhanced vaccination
Current attempts in vaccine delivery systems concentrate on replicating the natural dissemination of live pathogens, but n...
Discovery of novel non-peptidic and non-covalent small-molecule 3CLpro inhibitors as potential candidate for COVID-19 treatment
Discovery of novel non-peptidic and non-covalent small-molecule 3CLpro inhibitors as potential candidate for COVID-19 treatment
The global coronavirus disease 2019 (COVID-19) pandemic, which is caused by severe acute respiratory synd...
Epigenetic regulation in the tumor microenvironment: molecular mechanisms and therapeutic targets
Epigenetic regulation in the tumor microenvironment: molecular mechanisms and therapeutic targets
Over decades, researchers have focused on the epigenetic control of DNA-templated processes. Histone modification, DNA met...
Evolutionary characteristics of SARS-CoV-2 Omicron subvariants adapted to the host
Evolutionary characteristics of SARS-CoV-2 Omicron subvariants adapted to the host
As the COVID-19 epidemic proceeds, new variants of SARS-CoV-2 continue to emerge.1 Particularly the B.1.1...
Targeting small GTPases: emerging grasps on previously untamable targets, pioneered by KRAS
Targeting small GTPases: emerging grasps on previously untamable targets, pioneered by KRAS
Small GTPases including Ras, Rho, Rab, Arf, and Ran are omnipresent molecular switches in regulating key cellular function...
SARS-CoV-2 inhibition and specific targeting of infected cells by VSV particles carrying the ACE2 receptor
SARS-CoV-2 inhibition and specific targeting of infected cells by VSV particles carrying the ACE2 receptor
Effective vaccines and some antiviral agents against SARS-CoV-2, the causative agent of coronavirus disea...
Repression of interferon regulatory factor-4 (IRF4) hyperactivation restricts murine lupus
Repression of interferon regulatory factor-4 (IRF4) hyperactivation restricts murine lupus
Hyperactivation of the type I interferon (IFN) signature has been observed in several systemic autoimmune...
Deciphering dynamic changes of the aging transcriptome with COVID-19 progression and convalescence in the human blood
Deciphering dynamic changes of the aging transcriptome with COVID-19 progression and convalescence in the human blood
Overwhelming evidence suggests that age itself is a prominent risk factor for COVID-19 morbidity and mort...
Macrophages in immunoregulation and therapeutics
Macrophages in immunoregulation and therapeutics
Macrophages exist in various tissues, several body cavities, and around mucosal surfaces and are a vital part of the innat...
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