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Progress and prospects of mRNA-based drugs in pre-clinical and clinical applications
Progress and prospects of mRNA-based drugs in pre-clinical and clinical applications
In the last decade, messenger ribonucleic acid (mRNA)-based drugs have gained great interest in both immunotherapy and non...
Metformin: decelerates biomarkers of aging clocks
Metformin: decelerates biomarkers of aging clocks
A recent study published in Cell shows the widely known and used antidiabetic drug metformin, has ger...
Comparison of drug-eluting bead transarterial chemoembolization combined with apatinib versus drug-eluting bead transarterial chemoembolization for the treatment of unresectable hepatocellular carcinoma: a randomized, prospective, multicenter phase III trial
Comparison of drug-eluting bead transarterial chemoembolization combined with apatinib versus drug-eluting bead transarterial chemoembolization for the treatment of unresectable hepatocellular carcinoma: a randomized, prospective, multicenter phase III trial
This randomized, prospective, multicenter (12 centers in China) phase III trial (Chinese Clinical Trial Registry #ChiCTR20...
Post-fast refeeding: rise of intestinal stemness and mutagen-induced cancer risk through polyamine metabolism
Post-fast refeeding: rise of intestinal stemness and mutagen-induced cancer risk through polyamine metabolism
An increased intestinal stem cell activity following post fast-refeeding is beneficial for regenerati...
Overexpression of STX11 alleviates pulmonary fibrosis by inhibiting fibroblast activation via the PI3K/AKT/mTOR pathway
Overexpression of STX11 alleviates pulmonary fibrosis by inhibiting fibroblast activation via the PI3K/AKT/mTOR pathway
Fibroblast activation plays an important role in the occurrence and development of idiopathic pulmonary fibrosis (IPF), wh...
Moving towards precision psychiatry: the hard nut of depression
Moving towards precision psychiatry: the hard nut of depression
In a recent study published in Nature, Lynch et al.1 reported a consistent spatial expansion of the r...
Multiplexed RNAs in lipid nanoparticles: potential therapeutic vaccine for chronic hepatitis B
Multiplexed RNAs in lipid nanoparticles: potential therapeutic vaccine for chronic hepatitis B
A recent study published in Signal Transduction and Targeted Therapy by Wenjing Z. and Min Y. et al. ...
Intermittent high-fat diet: atherosclerosis progression by neutrophil reprogramming
Intermittent high-fat diet: atherosclerosis progression by neutrophil reprogramming
A recent study published in Nature by Lavillegrand et al. provided insights into how alternating high...
Mef2d: a novel transcription factor in type 2 allergic lung inflammation
Mef2d: a novel transcription factor in type 2 allergic lung inflammation
In a recent article published in Science, Szeto et al. identified myocyte-specific enhancer factor 2d...
Early intermittent cholesterol exposure accelerates atherosclerosis: an oscillating amplifier calling for preemptive control
Early intermittent cholesterol exposure accelerates atherosclerosis: an oscillating amplifier calling for preemptive control
A recent publication in Nature1 identified early intermittent hyperlipidemia as a new determinant of ...
Comprehensive snapshots of natural killer cells functions, signaling, molecular mechanisms and clinical utilization
Comprehensive snapshots of natural killer cells functions, signaling, molecular mechanisms and clinical utilization
Natural killer (NK) cells, initially identified for their rapid virus-infected and leukemia cell killing and tumor destruc...
First-line benmelstobart plus anlotinib and chemotherapy in advanced or metastatic/recurrent esophageal squamous cell carcinoma: a multi-center phase 2 study
First-line benmelstobart plus anlotinib and chemotherapy in advanced or metastatic/recurrent esophageal squamous cell carcinoma: a multi-center phase 2 study
Although first-line immunochemotherapy has improved prognosis for patients with advanced esophageal squamous cell carcinom...
First-in-human, phase 1 dose-escalation and dose-expansion study of a RET inhibitor SY-5007 in patients with advanced RET-altered solid tumors
First-in-human, phase 1 dose-escalation and dose-expansion study of a RET inhibitor SY-5007 in patients with advanced RET-altered solid tumors
Oncogenic RET alteration is an important, tissue-agnostic therapeutic target across diverse cancers. We conducted a first-...
A protein vaccine of RBD integrated with immune evasion mutation shows broad protection against SARS-CoV-2
A protein vaccine of RBD integrated with immune evasion mutation shows broad protection against SARS-CoV-2
Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue to emerge and evade immunity, resulting ...
Targeted protein degradation: advances in drug discovery and clinical practice
Targeted protein degradation: advances in drug discovery and clinical practice
Targeted protein degradation (TPD) represents a revolutionary therapeutic strategy in disease management, providing a star...
Human adipose and umbilical cord mesenchymal stem cell-derived extracellular vesicles mitigate photoaging via TIMP1/Notch1
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To ...
Mapping Alzheimer’s disease: exploring cellular vulnerability and resilience
Mapping Alzheimer’s disease: exploring cellular vulnerability and resilience
In a recent paper published in Nature, Mathys and co-workers presented a comprehensive and precise tr...
Miniproteins may have a big impact: new therapeutics for autoimmune diseases and beyond
Miniproteins may have a big impact: new therapeutics for autoimmune diseases and beyond
In a landmark study recently published in Cell, Berger et al. demonstrated that computationally desig...
Gut microbial carcinogen metabolism: another avenue to cancer
Gut microbial carcinogen metabolism: another avenue to cancer
A recent study published in Nature by Roje, Zhang and colleagues highlights the emergent role gut mic...
Perioperative sintilimab and neoadjuvant anlotinib plus chemotherapy for resectable non-small-cell lung cancer: a multicentre, open-label, single-arm, phase 2 trial (TD-NeoFOUR trial)
Perioperative sintilimab and neoadjuvant anlotinib plus chemotherapy for resectable non-small-cell lung cancer: a multicentre, open-label, single-arm, phase 2 trial (TD-NeoFOUR trial)
This open-label, single-arm, phase 2 trial evaluated the efficacy and safety of neoadjuvant sintilimab combined with anlot...
Corynebacterium parakroppenstedtii secretes a novel glycolipid to promote the development of granulomatous lobular mastitis
Corynebacterium parakroppenstedtii secretes a novel glycolipid to promote the development of granulomatous lobular mastitis
Granulomatous lobular mastitis (GLM) is a chronic idiopathic granulomatous mastitis of the mammary gland characterized by ...
MEK inhibition prevents CAR-T cell exhaustion and differentiation via downregulation of c-Fos and JunB
MEK inhibition prevents CAR-T cell exhaustion and differentiation via downregulation of c-Fos and JunB
Clinical evidence supports the notion that T cell exhaustion and terminal differentiation pose challenges to the persisten...
5-Formylcytosine: a new epigenetic player
5-Formylcytosine: a new epigenetic player
In a landmark study published in Cell, Parasyraki et al. demonstrated a functional role of 5-formylcy...
Systemic longitudinal immune profiling identifies proliferating Treg cells as predictors of immunotherapy benefit: biomarker analysis from the phase 3 CONTINUUM and DIPPER trials
Systemic longitudinal immune profiling identifies proliferating Treg cells as predictors of immunotherapy benefit: biomarker analysis from the phase 3 CONTINUUM and DIPPER trials
The identification of predictors for immunotherapy is often hampered by the absence of control groups in many studies, mak...
Ruxolitinib plus steroids for acute graft versus host disease: a multicenter, randomized, phase 3 trial
Ruxolitinib plus steroids for acute graft versus host disease: a multicenter, randomized, phase 3 trial
Newly diagnosed patients with high-risk acute graft-versus-host disease (aGVHD) often experience poor clinical outcomes an...
Integrate and conquer: pan-cancer proteogenomics uncovers cancer vulnerabilities and therapeutic opportunities
Integrate and conquer: pan-cancer proteogenomics uncovers cancer vulnerabilities and therapeutic opportunities
In a recent article published in Cell by Savage et al., the authors developed a computational workflo...
Cardiomyocyte-specific knockout of ADAM17 alleviates doxorubicin-induced cardiomyopathy via inhibiting TNFα–TRAF3–TAK1–MAPK axis
Cardiomyocyte-specific knockout of ADAM17 alleviates doxorubicin-induced cardiomyopathy via inhibiting TNFα–TRAF3–TAK1–MAPK axis
The pathogenesis of doxorubicin-induced cardiomyopathy remains unclear. This study was carried out to test our hypothesis ...
Correction: The JAK-STAT pathway: from structural biology to cytokine engineering
Correction: The JAK-STAT pathway: from structural biology to cytokine engineering
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
PD-1 and LAG-3: synergistic fostering of T cell exhaustion
PD-1 and LAG-3: synergistic fostering of T cell exhaustion
In the August issue of Cell 2024, three back-to-back papers disentangled non-redundant inhibitory mec...
Sequential responsive nano-PROTACs for precise intracellular delivery and enhanced degradation efficacy in colorectal cancer therapy
Sequential responsive nano-PROTACs for precise intracellular delivery and enhanced degradation efficacy in colorectal cancer therapy
PROteolysis TArgeting Chimeras (PROTACs) have been considered the next blockbuster therapies. However, due to their inhere...
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