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Pandemic punch: SARS-CoV-2 hits pancreas
Pandemic punch: SARS-CoV-2 hits pancreas
The COVID-19 pandemic has profoundly impacted global health systems, revealing the extensive repercus...
METTL14 downregulation drives S100A4+ monocyte-derived macrophages via MyD88/NF-κB pathway to promote MAFLD progression
METTL14 downregulation drives S100A4+ monocyte-derived macrophages via MyD88/NF-κB pathway to promote MAFLD progression
Without intervention, a considerable proportion of patients with metabolism‐associated fatty liver disease (MAFLD) w...
Phase II study of novel orally PI3Kα/δ inhibitor TQ-B3525 in relapsed and/or refractory follicular lymphoma
Phase II study of novel orally PI3Kα/δ inhibitor TQ-B3525 in relapsed and/or refractory follicular lymphoma
This registration study assessed clinical outcomes of TQ-B3525, the dual phosphatidylinositol-3-kinase (PI3K) α/δ...
Poly(A)-specific RNase (PARN) generates and regulates miR-125a-5p 3’-isoforms, displaying an altered expression in breast cancer
Poly(A)-specific RNase (PARN) generates and regulates miR-125a-5p 3’-isoforms, displaying an altered expression in breast cancer
MicroRNAs (miRNAs) are small non-coding RNAs crucial for post-transcriptional gene regulation, proces...
Anti-lymphangiogenesis for boosting drug accumulation in tumors
Anti-lymphangiogenesis for boosting drug accumulation in tumors
The inadequate tumor accumulation of anti-cancer agents is a major shortcoming of current therapeutic drugs and remains an...
Infection with SARS-CoV-2 can cause pancreatic impairment
Infection with SARS-CoV-2 can cause pancreatic impairment
Evidence suggests associations between COVID-19 patients or vaccines and glycometabolic dysfunction and an even higher ris...
G protein-coupled receptors (GPCRs): advances in structures, mechanisms, and drug discovery
G protein-coupled receptors (GPCRs): advances in structures, mechanisms, and drug discovery
G protein-coupled receptors (GPCRs), the largest family of human membrane proteins and an important class of drug targets,...
The gasdermin family: emerging therapeutic targets in diseases
The gasdermin family: emerging therapeutic targets in diseases
The gasdermin (GSDM) family has garnered significant attention for its pivotal role in immunity and disease as a key playe...
Thiamine-modified metabolic reprogramming of human pluripotent stem cell-derived cardiomyocyte under space microgravity
Thiamine-modified metabolic reprogramming of human pluripotent stem cell-derived cardiomyocyte under space microgravity
During spaceflight, the cardiovascular system undergoes remarkable adaptation to microgravity and faces the risk of cardia...
Circulating tumor cells shielded with extracellular vesicle-derived CD45 evade T cell attack to enable metastasis
Circulating tumor cells shielded with extracellular vesicle-derived CD45 evade T cell attack to enable metastasis
Circulating tumor cells (CTCs) are precursors of distant metastasis in a subset of cancer patients. A better understanding...
Protein neddylation and its role in health and diseases
Protein neddylation and its role in health and diseases
NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an ubiquitin-like protein that is coval...
Messing with cancer therapy: how the melanoma phenotype predicts checkpoint inhibitor response
Messing with cancer therapy: how the melanoma phenotype predicts checkpoint inhibitor response
In a study published in Cell, Pozniak et al. explored the spectrum of the phenotypic cell states of h...
Macrocyclic peptides: up-and-coming weapons to combat antimicrobial resistance
Macrocyclic peptides: up-and-coming weapons to combat antimicrobial resistance
Recently, two companion papers published in Nature reported a first-in-class tethered macrocyclic pep...
Neutrophils are shaped by the tumor microenvironment: novel possibilities for targeting neutrophils in cancer
Neutrophils are shaped by the tumor microenvironment: novel possibilities for targeting neutrophils in cancer
In a recent paper published in Science, Ng et al. provide seminal insights into the process through w...
Optimizing oncolytic virus design: a “Swiss army knife” approach to create a systemically delivered therapeutic
Optimizing oncolytic virus design: a “Swiss army knife” approach to create a systemically delivered therapeutic
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Mex-3 RNA binding family member A (MEX3A)/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy
Mex-3 RNA binding family member A (MEX3A)/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy
RNA-binding proteins (RBPs)-RNA networks have contributed to cancer development. Circular RNAs (circRNAs) are considered a...
Adeno-associated virus as a delivery vector for gene therapy of human diseases
Adeno-associated virus as a delivery vector for gene therapy of human diseases
Adeno-associated virus (AAV) has emerged as a pivotal delivery tool in clinical gene therapy owing to its minimal pathogen...
XELOX (capecitabine plus oxaliplatin) plus bevacizumab (anti-VEGF-A antibody) with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer: a multicenter, open-label, randomized, controlled, phase 3 trial
XELOX (capecitabine plus oxaliplatin) plus bevacizumab (anti-VEGF-A antibody) with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer: a multicenter, open-label, randomized, controlled, phase 3 trial
Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable m...
Progression from ductal carcinoma in situ to invasive breast cancer: molecular features and clinical significance
Progression from ductal carcinoma in situ to invasive breast cancer: molecular features and clinical significance
Ductal carcinoma in situ (DCIS) represents pre-invasive breast carcinoma. In untreated cases, 25–60% DCIS progress t...
The two sides of chromosomal instability: drivers and brakes in cancer
The two sides of chromosomal instability: drivers and brakes in cancer
Chromosomal instability (CIN) is a hallmark of cancer and is associated with tumor cell malignancy. CIN triggers a chain r...
Rapid development of double-hit mRNA antibody cocktail against orthopoxviruses
Rapid development of double-hit mRNA antibody cocktail against orthopoxviruses
The Orthopoxvirus genus, especially variola virus (VARV), monkeypox virus (MPXV), remains a significant public health thre...
RNA modifications in cellular metabolism: implications for metabolism-targeted therapy and immunotherapy
RNA modifications in cellular metabolism: implications for metabolism-targeted therapy and immunotherapy
Cellular metabolism is an intricate network satisfying bioenergetic and biosynthesis requirements of cells. Relevant studi...
First-line camrelizumab (a PD-1 inhibitor) plus apatinib (an VEGFR-2 inhibitor) and chemotherapy for advanced gastric cancer (SPACE): a phase 1 study
First-line camrelizumab (a PD-1 inhibitor) plus apatinib (an VEGFR-2 inhibitor) and chemotherapy for advanced gastric cancer (SPACE): a phase 1 study
Patients with advanced gastric cancer typically face a grim prognosis. This phase 1a (dose escalation) and phase 1b (dose ...
SARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl− concentration
SARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl− concentration
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection disrupts the epithelial barrier and triggers airway...
Harnessing innate immune pathways for therapeutic advancement in cancer
Harnessing innate immune pathways for therapeutic advancement in cancer
The innate immune pathway is receiving increasing attention in cancer therapy. This pathway is ubiquitous across various c...
Cholesterol business: life or death by rust
Cholesterol business: life or death by rust
In two recent manuscripts published in Nature, the cholesterol-synthesis pathway was identified as a ...
Correction: c-Myc-driven glycolysis polarizes functional regulatory B cells that trigger pathogenic inflammatory responses
Correction: c-Myc-driven glycolysis polarizes functional regulatory B cells that trigger pathogenic inflammatory responses
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
TGF-β signaling in health, disease, and therapeutics
TGF-β signaling in health, disease, and therapeutics
Transforming growth factor (TGF)-β is a multifunctional cytokine expressed by almost every tissue and cell type. The ...
Protein lipidation in health and disease: molecular basis, physiological function and pathological implication
Protein lipidation in health and disease: molecular basis, physiological function and pathological implication
Posttranslational modifications increase the complexity and functional diversity of proteins in response to complex extern...
Elevated Kallistatin promotes the occurrence and progression of non-alcoholic fatty liver disease
Elevated Kallistatin promotes the occurrence and progression of non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, and the development of non-a...
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