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Managing type 2 diabetes: targeting a microbial enzyme as a novel treatment option
Managing type 2 diabetes: targeting a microbial enzyme as a novel treatment option
In a recent Science article, Wang and colleagues showed that the dipeptidyl peptidase 4 (DPP4) enzyme...
IgE-Mast cell mediated allergy: a sensor of food quality
IgE-Mast cell mediated allergy: a sensor of food quality
In two recent studies published in Nature, Florsheim et al. and Plum et al. reported that allergic-sp...
Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity
Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity
Ligand-induced receptor dimerization or oligomerization is a widespread mechanism for ensuring communication specificity, ...
Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases
Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases
Ferroptosis, a unique modality of cell death with mechanistic and morphological differences from other cell death modes, p...
Methyltransferase-like 3 (METTL3) inhibition potentiates anti-tumor immunity: a novel strategy for improving anti-PD1 therapy
Methyltransferase-like 3 (METTL3) inhibition potentiates anti-tumor immunity: a novel strategy for improving anti-PD1 therapy
In a recent article published in Cancer Discovery, Guirguis et al. demonstrated that enzymatic inhibi...
Tau in the pancreas: understanding the link between type 2 diabetes mellitus and Alzheimer’s disease
Tau in the pancreas: understanding the link between type 2 diabetes mellitus and Alzheimer’s disease
A recent study published in Molecular Psychiatry proposes a cellular mechanism that may contribute to...
Neoadjuvant nivolumab with or without platinum-doublet chemotherapy based on PD-L1 expression in resectable NSCLC (CTONG1804): a multicenter open-label phase II study
Neoadjuvant nivolumab with or without platinum-doublet chemotherapy based on PD-L1 expression in resectable NSCLC (CTONG1804): a multicenter open-label phase II study
This prospective multicenter phase II study evaluated the clinical efficacy of neoadjuvant nivolumab-exclusive (N) and niv...
Gut liver brain axis in diseases: the implications for therapeutic interventions
Gut liver brain axis in diseases: the implications for therapeutic interventions
Gut-liver-brain axis is a three-way highway of information interaction system among the gastrointestinal tract, liver, and...
Non-coding RNAs expression in SARS-CoV-2 infection: pathogenesis, clinical significance, and therapeutic targets
Non-coding RNAs expression in SARS-CoV-2 infection: pathogenesis, clinical significance, and therapeutic targets
The coronavirus disease 2019 (COVID-19) pandemic has been looming globally for three years, yet the diagnostic and treatme...
Going only half the way: cell cycle exit after the G1 restriction point
Going only half the way: cell cycle exit after the G1 restriction point
In a recent article published in Nature, James A. Cornwell et al. describe that cyclin A2 levels dete...
SARS-CoV-2 Omicron subvariant BA.2.86: limited potential for global spread
SARS-CoV-2 Omicron subvariant BA.2.86: limited potential for global spread
In recent studies published in Nature and Lancet Infectious Diseases,1,2 SARS-CoV-2 Omicron subvarian...
Oncolytic adenoviruses expressing checkpoint inhibitors for cancer therapy
Oncolytic adenoviruses expressing checkpoint inhibitors for cancer therapy
Despite the remarkable success of immune checkpoint inhibitors (ICIs), primary resistance to ICIs causes only subsets of p...
γδ T cells: origin and fate, subsets, diseases and immunotherapy
γδ T cells: origin and fate, subsets, diseases and immunotherapy
The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and hyperactivation, highlights the...
Multifunctional mesoporous silica nanoparticles for biomedical applications
Multifunctional mesoporous silica nanoparticles for biomedical applications
Mesoporous silica nanoparticles (MSNs) are recognized as a prime example of nanotechnology applied in the biomedical field...
Correction: Eosinophils promote pulmonary matrix destruction and emphysema via Cathepsin L
Correction: Eosinophils promote pulmonary matrix destruction and emphysema via Cathepsin L
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Signaling pathways and targeted therapies for psoriasis
Signaling pathways and targeted therapies for psoriasis
Psoriasis is a common, chronic, and inflammatory skin disease with a high burden on individuals, health systems, and socie...
The Vγ4/butyrophilin conspiracy: novel role of intraepithelial γδ T cells in chronic inflammatory bowel disease
The Vγ4/butyrophilin conspiracy: novel role of intraepithelial γδ T cells in chronic inflammatory bowel disease
In a recent article published in Science, Dart and colleagues reported that colonic T cells expressing th...
Versatile guardians: regenerative regulatory T cells in Parkinson’s disease rodent models
Versatile guardians: regenerative regulatory T cells in Parkinson’s disease rodent models
In a paper published in Nature, Park and colleagues have explored an innovative approach for improving ad...
Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets
Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets
Hypoxia, characterized by reduced oxygen concentration, is a significant stressor that affects the survival of aerobic spe...
Sellhi neutrophils: a key to triumph in cancer therapy
Sellhi neutrophils: a key to triumph in cancer therapy
In a recent study published in Cell, Gungabeesoon and colleagues1 demonstrated that a specific subpopulat...
Single-cell genomics: the human biomolecular and cell atlases
Single-cell genomics: the human biomolecular and cell atlases
Recently, in a series of three papers published in Nature, the Human Biomolecular Atlas Program (HuBMAP) ...
Metatranscriptome of human lung microbial communities in a cohort of mechanically ventilated COVID-19 Omicron patients
Metatranscriptome of human lung microbial communities in a cohort of mechanically ventilated COVID-19 Omicron patients
The Omicron variant of the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infected a substantial...
Nuclear transport proteins: structure, function, and disease relevance
Nuclear transport proteins: structure, function, and disease relevance
Proper subcellular localization is crucial for the functioning of biomacromolecules, including proteins and RNAs. Nuclear ...
Decoding γδ T cell anticancer therapies: integrating CRISPR screens with tumor organoids
Decoding γδ T cell anticancer therapies: integrating CRISPR screens with tumor organoids
In a recent publication in Nature,1 Mamedov and colleagues identified pathways that modulate γδ T cell ki...
Transcriptional co-activators: emerging roles in signaling pathways and potential therapeutic targets for diseases
Transcriptional co-activators: emerging roles in signaling pathways and potential therapeutic targets for diseases
Specific cell states in metazoans are established by the symphony of gene expression programs that necessitate intricate s...
Microcolin H, a novel autophagy inducer, exerts potent antitumour activity by targeting PITPα/β
Microcolin H, a novel autophagy inducer, exerts potent antitumour activity by targeting PITPα/β
The identification of effective drug targets and the development of bioactive molecules are areas of high need in cancer t...
Predictive biomarkers of response and survival following immunotherapy with a PD-L1 inhibitor benmelstobart (TQB2450) and antiangiogenic therapy with a VEGFR inhibitor anlotinib for pretreated advanced triple negative breast cancer
Predictive biomarkers of response and survival following immunotherapy with a PD-L1 inhibitor benmelstobart (TQB2450) and antiangiogenic therapy with a VEGFR inhibitor anlotinib for pretreated advanced triple negative breast cancer
In our phase Ib trial (ClinialTrials.gov Identifier: NCT03855358), benmelstobart (TQB2450), a novel humanized IgG1 antibod...
Characteristics of premanufacture CD8+T cells determine CAR-T efficacy in patients with diffuse large B-cell lymphoma
Characteristics of premanufacture CD8+T cells determine CAR-T efficacy in patients with diffuse large B-cell lymphoma
Although chimeric antigen receptor (CAR) T cells have become an important treatment option for patients with relapsed/refr...
Phase II trial of CDK4/6 inhibitor palbociclib in advanced sarcoma based on mRNA expression of CDK4/ CDKN2A
Phase II trial of CDK4/6 inhibitor palbociclib in advanced sarcoma based on mRNA expression of CDK4/ CDKN2A
Cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors demonstrated activity in terms of progression-free survival (PFS) in ...
Cyst fluid glycoproteins accurately distinguishing malignancies of pancreatic cystic neoplasm
Cyst fluid glycoproteins accurately distinguishing malignancies of pancreatic cystic neoplasm
Pancreatic cystic neoplasms (PCNs) are recognized as precursor lesions of pancreatic cancer, with a marked increase in pre...
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