SCI时时刷

search
+
Macrophages need to release the proximal brake to degrade cellular corpses
Macrophages need to release the proximal brake to degrade cellular corpses
Writing in Nature, T. Tufan et al.1 address this gap in knowledge and provide novel functional and mechanistic insight int...
Membrane-embedded machines
The first membrane protein structure was reported almost 40 years ago. In this issue, we are publishing a set of papers th...
Future opportunities in solute carrier structural biology
Future opportunities in solute carrier structural biology
Solute carriers (SLCs) control the flow of small molecules and ions across biological membranes. Over the last 20 years, t...
Author Correction: RNA polymerase II pausing regulates chromatin organization in erythrocytes
Authors and AffiliationsDepartamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma...
Vimentin filaments integrate low-complexity domains in a complex helical structure
Vimentin filaments integrate low-complexity domains in a complex helical structure
Intermediate filaments (IFs) are integral components of the cytoskeleton. They provide cells with tissue-specific mechanic...
DNA double-strand break–capturing nuclear envelope tubules drive DNA repair
DNA double-strand break–capturing nuclear envelope tubules drive DNA repair
Current models suggest that DNA double-strand breaks (DSBs) can move to the nuclear periphery for repair. It is unclear to...
HS-AFM single-molecule structural biology uncovers basis of transporter wanderlust kinetics
HS-AFM single-molecule structural biology uncovers basis of transporter wanderlust kinetics
The Pyrococcus horikoshii amino acid transporter GltPh revealed, like other channels and transporters, activity mode switc...
Molecular basis of Gabija anti-phage supramolecular assemblies
Molecular basis of Gabija anti-phage supramolecular assemblies
As one of the most prevalent anti-phage defense systems in prokaryotes, Gabija consists of a Gabija protein A (GajA) and a...
Structure of the γ-tubulin ring complex-capped microtubule
Structure of the γ-tubulin ring complex-capped microtubule
Microtubules are composed of α-tubulin and β-tubulin dimers positioned head-to-tail to form protofilaments that ...
Structure of the native γ-tubulin ring complex capping spindle microtubules
Structure of the native γ-tubulin ring complex capping spindle microtubules
Microtubule (MT) filaments, composed of α/β-tubulin dimers, are fundamental to cellular architecture, function a...
Visualizing chaperone-mediated multistep assembly of the human 20S proteasome
Visualizing chaperone-mediated multistep assembly of the human 20S proteasome
Dedicated assembly factors orchestrate the stepwise production of many molecular machines, including the 28-subunit protea...
Mechanism of autocatalytic activation during proteasome assembly
Mechanism of autocatalytic activation during proteasome assembly
Many large molecular machines are too elaborate to assemble spontaneously and are built through ordered pathways orchestra...
Noncanonical assembly, neddylation and chimeric cullin–RING/RBR ubiquitylation by the 1.8 MDa CUL9 E3 ligase complex
Noncanonical assembly, neddylation and chimeric cullin–RING/RBR ubiquitylation by the 1.8 MDa CUL9 E3 ligase complex
Ubiquitin ligation is typically executed by hallmark E3 catalytic domains. Two such domains, ‘cullin–RING̵...
Structure of adenylyl cyclase 5 in complex with Gβγ offers insights into ADCY5-related dyskinesia
Structure of adenylyl cyclase 5 in complex with Gβγ offers insights into ADCY5-related dyskinesia
The nine different membrane-anchored adenylyl cyclase isoforms (AC1–9) in mammals are stimulated by the heterotrimer...
Transport mechanism of presynaptic high-affinity choline uptake by CHT1
Transport mechanism of presynaptic high-affinity choline uptake by CHT1
Choline is a vital nutrient and a precursor for the biosynthesis of essential metabolites, including acetylcholine (ACh), ...
Author Correction: Structural basis for partial agonism in 5-HT3A receptors
Author notesThese authors contributed equally: Madeleine Stauffer, Leslie Salas-Estrada.Authors and AffiliationsDepartment...
SCAF1 drives the compositional diversity of mammalian respirasomes
SCAF1 drives the compositional diversity of mammalian respirasomes
Supercomplexes of the respiratory chain are established constituents of the oxidative phosphorylation system, but their ro...
Shifting our perspective on orphan G protein-coupled receptors
G protein-coupled receptors (GPCRs) with no known endogenous ligand are termed orphans. Deorphanization of a GPCR involves...
Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ
Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ
The conversion of phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 3,4,5-triphosphate by phosphoinositide 3-k...
A rare genetic variant biases maternal meiotic recombination toward risk of pregnancy loss
A rare genetic variant biases maternal meiotic recombination toward risk of pregnancy loss
Pregnancy loss is common in humans, but maternal genetic factors modulating its incidence are largely unknown. In a meta-a...
Structural insights into the decoding capability of isoleucine tRNAs with lysidine and agmatidine
Structural insights into the decoding capability of isoleucine tRNAs with lysidine and agmatidine
The anticodon modifications of transfer RNAs (tRNAs) finetune the codon recognition on the ribosome for accurate translati...
Structures of the ribosome bound to EF-Tu–isoleucine tRNA elucidate the mechanism of AUG avoidance
Structures of the ribosome bound to EF-Tu–isoleucine tRNA elucidate the mechanism of AUG avoidance
The frequency of errors upon decoding of messenger RNA by the bacterial ribosome is low, with one misreading event per 1&#...
Molecular stripping underpins derepression of a toxin–antitoxin system
Molecular stripping underpins derepression of a toxin–antitoxin system
Transcription factors control gene expression; among these, transcriptional repressors must liberate the promoter for dere...
A personal perspective of the voltage-gated potassium channel studies
The identification of sodium and potassium currents as underlying action potential propagation, more than 70 years ago, op...
An oligopeptide permease, OppABCD, requires an iron–sulfur cluster domain for functionality
An oligopeptide permease, OppABCD, requires an iron–sulfur cluster domain for functionality
Oligopeptide permease, OppABCD, belongs to the type I ABC transporter family. Its role is to import oligopeptides into bac...
High-resolution structures of amyloid-β and tau aggregates in individuals with Down syndrome
High-resolution structures of amyloid-β and tau aggregates in individuals with Down syndrome
Cryo-electron microscopy of brain tissue from two individuals with Down syndrome showed amyloid-β (Aβ) and tau f...
Cryo-EM structures of amyloid-β and tau filaments in Down syndrome
Cryo-EM structures of amyloid-β and tau filaments in Down syndrome
Adult individuals with Down syndrome (DS) develop Alzheimer disease (AD). Whether there is a difference between AD in DS a...
Structural basis of the histone ubiquitination read–write mechanism of RYBP–PRC1
Structural basis of the histone ubiquitination read–write mechanism of RYBP–PRC1
Histone H2A monoubiquitination (H2Aub1) by the PRC1 subunit RING1B entails a positive feedback loop, mediated by the RING1...
Author Correction: Structure and interactions of the endogenous human Commander complex
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Musings on art and science
Musings on art and science
In addition to the usual dose of compelling science, our March issue features thoughtful reflections on the last 30 years ...
阅读更多
format_indent_increase