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Architecture and activation of single-pass transmembrane receptor guanylyl cyclase
Architecture and activation of single-pass transmembrane receptor guanylyl cyclase
The heart, in addition to its primary role in blood circulation, functions as an endocrine organ by producing cardiac horm...
Menopause age and cancer risk is influenced by rare genetic variants
Menopause age and cancer risk is influenced by rare genetic variants
Using data from the UK Biobank the researchers analyzed the rare variants in the protein coding region in the genomes of 1...
Structural basis of the mechanism and inhibition of a human ceramide synthase
Structural basis of the mechanism and inhibition of a human ceramide synthase
Ceramides are bioactive sphingolipids crucial for regulating cellular metabolism. Ceramides and dihydroceramides are synth...
Structure of the yeast ceramide synthase
Structure of the yeast ceramide synthase
Ceramides are essential lipids involved in forming complex sphingolipids and acting as signaling molecules. They result fr...
Mechanism for Vipp1 spiral formation, ring biogenesis, and membrane repair
Mechanism for Vipp1 spiral formation, ring biogenesis, and membrane repair
The ESCRT-III-like protein Vipp1 couples filament polymerization with membrane remodeling. It assembles planar sheets as w...
Cryo-electron tomography reveals how COPII assembles on cargo-containing membranes
Cryo-electron tomography reveals how COPII assembles on cargo-containing membranes
Proteins traverse the eukaryotic secretory pathway through membrane trafficking between organelles. The coat protein compl...
Cryo-EM structure of the heteromeric TRPC1/TRPC4 channel
Cryo-EM structure of the heteromeric TRPC1/TRPC4 channel
Transient receptor potential (TRP) ion channels have a crucial role as cellular sensors, mediating diverse physical and ch...
Tubulin acetyltransferases access and modify the microtubule luminal K40 residue through anchors in taxane-binding pockets
Tubulin acetyltransferases access and modify the microtubule luminal K40 residue through anchors in taxane-binding pockets
Acetylation at α-tubulin K40 is the sole post-translational modification preferred to occur inside the lumen of hollo...
DNA methylation shapes the Polycomb landscape during the exit from naive pluripotency
DNA methylation shapes the Polycomb landscape during the exit from naive pluripotency
In mammals, 5-methylcytosine (5mC) and Polycomb repressive complex 2 (PRC2)-deposited histone 3 lysine 27 trimethylation (...
Mechanism of actin filament severing and capping by gelsolin
Mechanism of actin filament severing and capping by gelsolin
Gelsolin is the prototypical member of a family of Ca2+-activated F-actin severing and capping proteins. Here we report st...
Author Correction: Structural basis for antibody-mediated NMDA receptor clustering and endocytosis in autoimmune encephalitis
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 ...
TMEM63B scrambles phospholipids in response to changes in membrane structure
TMEM63B scrambles phospholipids in response to changes in membrane structure
Phospholipid distribution across the lipid bilayer of plasma membranes is critical for various cellular functions. A genom...
Publisher Correction: Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Clamping Pol ε to the leading strand
Clamping Pol ε to the leading strand
Two recent studies provide structural insights into how human DNA polymerase ε (Pol ε) interacts with PCNA to fo...
Membrane structure-responsive lipid scrambling by TMEM63B to control plasma membrane lipid distribution
Membrane structure-responsive lipid scrambling by TMEM63B to control plasma membrane lipid distribution
Phospholipids are asymmetrically distributed in the plasma membrane (PM), with phosphatidylcholine and sphingomyelin abund...
Mechanism of polyadenylation-independent RNA polymerase II termination
Mechanism of polyadenylation-independent RNA polymerase II termination
The mechanisms underlying the initiation and elongation of RNA polymerase II (Pol II) transcription are well-studied, wher...
Time-course remodeling and pathology intervention of α-synuclein amyloid fibril by heparin and heparin-like oligosaccharides
Time-course remodeling and pathology intervention of α-synuclein amyloid fibril by heparin and heparin-like oligosaccharides
Amyloid fibrils represent a pathological state of protein polymer that is closely associated with various neurodegenerativ...
Cohesin closes the door on coexpression
Cohesin closes the door on coexpression
Dong et al. relied on a mouse embryonic stem (ES) cell line where the cohesin subunit, RAD21, had been tagged with an auxi...
The guanylate-binding protein GBP1 forms a protein coat that enwraps cytosol-invasive bacteria
The guanylate-binding protein GBP1 forms a protein coat that enwraps cytosol-invasive bacteria
GBP1 is an important innate immunity component that contributes to the control of cytosol-invasive bacterial pathogens. Us...
Structural basis of antimicrobial membrane coat assembly by human GBP1
Structural basis of antimicrobial membrane coat assembly by human GBP1
Guanylate-binding proteins (GBPs) are interferon-inducible guanosine triphosphate hydrolases (GTPases) mediating host defe...
Cryo-EM structure of the human subcortical maternal complex and the associated discovery of infertility-associated variants
Cryo-EM structure of the human subcortical maternal complex and the associated discovery of infertility-associated variants
The functionally conserved subcortical maternal complex (SCMC) is essential for early embryonic development in mammals. Re...
Structural basis for Vipp1 membrane binding: from loose coats and carpets to ring and rod assemblies
Structural basis for Vipp1 membrane binding: from loose coats and carpets to ring and rod assemblies
Vesicle-inducing protein in plastids 1 (Vipp1) is critical for thylakoid membrane biogenesis and maintenance. Although Vip...
Mesoscale chromatin confinement facilitates target search of pioneer transcription factors in live cells
Mesoscale chromatin confinement facilitates target search of pioneer transcription factors in live cells
Pioneer transcription factors (PTFs) possess the unique capability to access closed chromatin regions and initiate cell fa...
Structure of Fanzor2 reveals insights into the evolution of the TnpB superfamily
Structure of Fanzor2 reveals insights into the evolution of the TnpB superfamily
RNA-guided endonucleases, once thought to be exclusive to prokaryotes, have been recently identified in eukaryotes and are...
Insights into reproduction-regulating NOD-like receptors
Insights into reproduction-regulating NOD-like receptors
An understudied subset of NOD-like receptors are involved in the reproductive system, and their dysfunction can cause infe...
Structural insights into translocation and tailored synthesis of hyaluronan
Structural insights into translocation and tailored synthesis of hyaluronan
Hyaluronan (HA) is an essential component of the vertebrate extracellular matrix. It is a heteropolysaccharide of N-acetyl...
Structural features within the NORAD long noncoding RNA underlie efficient repression of Pumilio activity
Structural features within the NORAD long noncoding RNA underlie efficient repression of Pumilio activity
Long noncoding RNAs (lncRNAs) are increasingly appreciated for their important functions in mammalian cells. However, how ...
Structural insights into CXCR4 modulation and oligomerization
Structural insights into CXCR4 modulation and oligomerization
Activation of the chemokine receptor CXCR4 by its chemokine ligand CXCL12 regulates diverse cellular processes. Previously...
Super-silencer perturbation by EZH2 and REST inhibition leads to large loss of chromatin interactions and reduction in cancer growth
Super-silencer perturbation by EZH2 and REST inhibition leads to large loss of chromatin interactions and reduction in cancer growth
Human silencers have been shown to regulate developmental gene expression. However, the functional importance of human sil...
Cryo-EM structures of the Spo11 core complex bound to DNA
Cryo-EM structures of the Spo11 core complex bound to DNA
DNA double-strand breaks that initiate meiotic recombination are formed by the topoisomerase-relative enzyme Spo11, suppor...
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