SCI时时刷

search
+
Captured: the elusive eukaryotic tRNA splicing enzyme
Captured: the elusive eukaryotic tRNA splicing enzyme
The maturation of transfer RNAs requires the splicing of precursor tRNAs by specific endonucleases. New cryo-electron micr...
Structural basis for pre-tRNA recognition and processing by the human tRNA splicing endonuclease complex
Structural basis for pre-tRNA recognition and processing by the human tRNA splicing endonuclease complex
Throughout bacteria, archaea and eukarya, certain tRNA transcripts contain introns. Pre-tRNAs with introns require splicin...
Surveying the global landscape of post-transcriptional regulators
Surveying the global landscape of post-transcriptional regulators
Numerous proteins regulate gene expression by modulating mRNA translation and decay. To uncover the full scope of these po...
Structural basis of substrate recognition by human tRNA splicing endonuclease TSEN
Structural basis of substrate recognition by human tRNA splicing endonuclease TSEN
Heterotetrameric human transfer RNA (tRNA) splicing endonuclease TSEN catalyzes intron excision from precursor tRNAs (pre-...
A look into the dynamic process of proofreading in DNA polymerase-γ at near-atomic resolution
A look into the dynamic process of proofreading in DNA polymerase-γ at near-atomic resolution
The correction of errors during mitochondrial DNA replication by the proofreading function of DNA polymerase-γ is cru...
Nucleolus assembly impairment leads to two-cell transcriptional repression via NPM1-mediated PRC2 recruitment
Nucleolus assembly impairment leads to two-cell transcriptional repression via NPM1-mediated PRC2 recruitment
The nucleolus is a compartmentalized organelle in eukaryotic cells known to form during embryogenesis, yet how its layered...
H4S47 O-GlcNAcylation regulates the activation of mammalian replication origins
H4S47 O-GlcNAcylation regulates the activation of mammalian replication origins
The transmission and maintenance of genetic information in eukaryotic cells relies on the faithful duplication of the enti...
Polγ coordinates DNA synthesis and proofreading to ensure mitochondrial genome integrity
Polγ coordinates DNA synthesis and proofreading to ensure mitochondrial genome integrity
Accurate replication of mitochondrial DNA (mtDNA) by DNA polymerase γ (Polγ) is essential for maintaining cellul...
RNA stability controlled by m6A methylation contributes to X-to-autosome dosage compensation in mammals
RNA stability controlled by m6A methylation contributes to X-to-autosome dosage compensation in mammals
In mammals, X-chromosomal genes are expressed from a single copy since males (XY) possess a single X chromosome, while fem...
Phosphatidylserine-dependent structure of synaptogyrin remodels the synaptic vesicle membrane
Phosphatidylserine-dependent structure of synaptogyrin remodels the synaptic vesicle membrane
Synaptic vesicles are small membrane-enclosed organelles that store neurotransmitters at presynaptic terminals. The unifor...
Intrinsic mesoscale properties of a Polycomb protein underpin heterochromatin fidelity
Intrinsic mesoscale properties of a Polycomb protein underpin heterochromatin fidelity
Little is understood about how the two major types of heterochromatin domains (HP1 and Polycomb) are kept separate. In the...
Smc5/6 caught in the act of loop extrusion
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
Aging RNA Polymerase II may speed recklessly
Aging undermines the efficiency and fidelity of countless cellular processes. While we understand how aging impinges on ge...
Molecular basis of the TRAP complex function in ER protein biogenesis
Molecular basis of the TRAP complex function in ER protein biogenesis
The translocon-associated protein (TRAP) complex resides in the endoplasmic reticulum (ER) membrane and interacts with the...
MAVS deSUMOylation by SENP1 inhibits its aggregation and antagonizes IRF3 activation
MAVS deSUMOylation by SENP1 inhibits its aggregation and antagonizes IRF3 activation
Mitochondrial antiviral signaling protein (MAVS) is an adapter that recruits and activates IRF3. However, the mechanisms u...
Author Correction: Smc5/6 silences episomal transcription by a three-step function
Authors and AffiliationsDepartment of Microbiology and Molecular Medicine, University Medical Centre, Geneva, SwitzerlandF...
Structural basis of metabolite transport by the chloroplast outer envelope channel OEP21
Structural basis of metabolite transport by the chloroplast outer envelope channel OEP21
Triose phosphates (TPs) are the primary products of photosynthetic CO2 fixation in chloroplasts, which need to be exported...
PARP1 and HPF1 team up to flag down DNA-repair machinery
PARP1 and HPF1 team up to flag down DNA-repair machinery
The enzymatic activity of PARP1—which adds chains of (poly-ADP)-ribose (PAR) to proteins—initiates DNA repair ...
Quantifying how promoter-associated nucleosomes regulate transcriptional bursting
Quantifying how promoter-associated nucleosomes regulate transcriptional bursting
Single-molecule live-cell imaging of the transcription dynamics in budding yeast cells revealed that the remodeling of dif...
Structural basis for RNA slicing by a plant Argonaute
Structural basis for RNA slicing by a plant Argonaute
Argonaute (AGO) proteins use small RNAs to recognize transcripts targeted for silencing in plants and animals. Many AGOs c...
Dynamic epistasis analysis reveals how chromatin remodeling regulates transcriptional bursting
Dynamic epistasis analysis reveals how chromatin remodeling regulates transcriptional bursting
Transcriptional bursting has been linked to the stochastic positioning of nucleosomes. However, how bursting is regulated ...
HPF1-dependent histone ADP-ribosylation triggers chromatin relaxation to promote the recruitment of repair factors at sites of DNA damage
HPF1-dependent histone ADP-ribosylation triggers chromatin relaxation to promote the recruitment of repair factors at sites of DNA damage
Poly(ADP-ribose) polymerase 1 (PARP1) activity is regulated by its co-factor histone poly(ADP-ribosylation) factor 1 (HPF1...
Structural basis for TBP displacement from TATA box DNA by the Swi2/Snf2 ATPase Mot1
Structural basis for TBP displacement from TATA box DNA by the Swi2/Snf2 ATPase Mot1
The Swi2/Snf2 family transcription regulator Modifier of Transcription 1 (Mot1) uses adenosine triphosphate (ATP) to disso...
Structural basis for Fc receptor recognition of immunoglobulin M
Structural basis for Fc receptor recognition of immunoglobulin M
Immunoglobulin Fc receptors are cell surface transmembrane proteins that bind to the Fc constant region of antibodies and ...
Staying afloat: the structure of gas vesicles
Staying afloat: the structure of gas vesicles
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
Human primase hangs on the primer–template and Polα to facilitate primer termination
Human primase hangs on the primer–template and Polα to facilitate primer termination
We determined the structure of the Polα–primase complex trapped in a DNA elongation state. Cryo-electron micros...
Structural basis of centromeric cohesion protection
Structural basis of centromeric cohesion protection
In the early stages of mitosis, cohesin is released from chromosome arms but not from centromeres. The protection of centr...
Structure of a SIN3–HDAC complex from budding yeast
Structure of a SIN3–HDAC complex from budding yeast
SIN3–HDAC (histone deacetylases) complexes have important roles in facilitating local histone deacetylation to regul...
Structural inventory of cotranslational protein folding by the eukaryotic RAC complex
Structural inventory of cotranslational protein folding by the eukaryotic RAC complex
The challenge of nascent chain folding at the ribosome is met by the conserved ribosome-associated complex (RAC), which fo...
The RNA m6A landscape of mouse oocytes and preimplantation embryos
The RNA m6A landscape of mouse oocytes and preimplantation embryos
Despite the significance of N6-methyladenosine (m6A) in gene regulation, the requirement for large amounts of RNA has hind...
阅读更多
format_indent_increase