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Balancing reproductive pursuit and visual danger
Humans and other animals wittingly or unwittingly run risk–benefit analyses daily. For animals of reproductive age, a prim...
Integrative analysis of the 3D genome and epigenome in mouse embryonic tissues
Integrative analysis of the 3D genome and epigenome in mouse embryonic tissues
While a rich set of putative cis-regulatory sequences involved in mouse fetal development have been annotated recently on ...
30 years of structural and molecular biology and counting
As 2024 closes, we take this opportunity to reflect on the highlights of our 30th anniversary year and consider what the f...
Visualizing antibiotic action in a pathogenic bacterium at atomic to cellular scale
Visualizing antibiotic action in a pathogenic bacterium at atomic to cellular scale
The mechanisms of antibiotic action can be highly context specific. Using in-cell cryo-electron tomography (cryo-ET) of My...
African ancestry neurodegeneration risk variant disrupts an intronic branchpoint in GBA1
African ancestry neurodegeneration risk variant disrupts an intronic branchpoint in GBA1
Recently, an African ancestry-specific Parkinson disease (PD) risk signal was identified at the gene encoding glucocerebro...
Structural insights into context-dependent inhibitory mechanisms of chloramphenicol in cells
Structural insights into context-dependent inhibitory mechanisms of chloramphenicol in cells
Ribosome-targeting antibiotics represent an important class of antimicrobial drugs. Chloramphenicol (Cm) is a well-studied...
Structural basis of human γ-secretase inhibition by anticancer clinical compounds
Structural basis of human γ-secretase inhibition by anticancer clinical compounds
Aberrant activation of Notch signaling, mediated by the Notch intracellular domain (NICD), is linked to certain types of c...
Understanding ubiquitination in neurodevelopment by integrating insights across space and time
Understanding ubiquitination in neurodevelopment by integrating insights across space and time
Ubiquitination regulates a myriad of eukaryotic signaling cascades by modifying substrate proteins, thereby determining th...
Substrate translocation and inhibition in human dicarboxylate transporter NaDC3
Substrate translocation and inhibition in human dicarboxylate transporter NaDC3
The human high-affinity sodium–dicarboxylate cotransporter (NaDC3) imports various substrates into the cell as trica...
Looking back at the timely launch of Nature Structural Biology in 1994
Structural biology has continued to advance over the past decades, owing to the development of improved and new technologi...
Keeping in touch with the road not taken
Keeping in touch with the road not taken
I thank D. Shaw, C. Tsimbal, Y. Xu and A. Ionescu for detailed comments. I currently receive support from NIH grant R21AG0...
Closed and open structures of the eukaryotic magnesium channel Mrs2 reveal the auto-ligand-gating regulation mechanism
Closed and open structures of the eukaryotic magnesium channel Mrs2 reveal the auto-ligand-gating regulation mechanism
The CorA/Mrs2 family of pentameric proteins are cardinal for the influx of Mg2+ across cellular membranes, importing the c...
Structure and function of the human mitochondrial MRS2 channel
Structure and function of the human mitochondrial MRS2 channel
The human mitochondrial RNA splicing 2 protein (MRS2) has been implicated in Mg2+ transport across mitochondrial inner mem...
Supporting structural biologists in Africa requires resources and capacity building
E.N. is funded by the Wellcome Trust (grant number 222999/Z/21/Z) and is a recipient of the Google award for “Support for ...
Diverse anti-NMDAR autoantibodies from individuals with encephalitis
Diverse anti-NMDAR autoantibodies from individuals with encephalitis
Autoantibodies targeting glutamatergic N-methyl-d-aspartic acid receptors (NMDARs) are found in people with anti-NMDAR enc...
A lesson in symmetry
A lesson in symmetry
Duarte, J. M., Dutta, S., Goodsell, D. S. & Burley, S. K. Emerg. Top. Life Sci. 6, 231–243 (2022).Article  CAS  ...
The yeast genome is globally accessible in living cells
The yeast genome is globally accessible in living cells
Eukaryotic genomes are packaged into chromatin, which is composed of condensed filaments of regularly spaced nucleosomes, ...
Evolution and function of chromatin domains across the tree of life
Evolution and function of chromatin domains across the tree of life
The genome of all organisms is spatially organized to function efficiently. The advent of genome-wide chromatin conformati...
Na+-V-ATPase inhibitor curbs VRE growth and unveils Na+ pathway structure
Na+-V-ATPase inhibitor curbs VRE growth and unveils Na+ pathway structure
Vancomycin-resistant Enterococcus faecium (VRE) is a major cause of nosocomial infections, particularly endocarditis and s...
Structural insights into SV2A and the mechanism of racetam anticonvulsants
Structural insights into SV2A and the mechanism of racetam anticonvulsants
Racetam anticonvulsants, such as levetiracetam, are widely prescribed to treat and prevent seizures. Despite decades of cl...
Architecture and activation of single-pass transmembrane receptor guanylyl cyclase
Architecture and activation of single-pass transmembrane receptor guanylyl cyclase
The heart, in addition to its primary role in blood circulation, functions as an endocrine organ by producing cardiac horm...
Menopause age and cancer risk is influenced by rare genetic variants
Menopause age and cancer risk is influenced by rare genetic variants
Using data from the UK Biobank the researchers analyzed the rare variants in the protein coding region in the genomes of 1...
Structural basis of the mechanism and inhibition of a human ceramide synthase
Structural basis of the mechanism and inhibition of a human ceramide synthase
Ceramides are bioactive sphingolipids crucial for regulating cellular metabolism. Ceramides and dihydroceramides are synth...
Structure of the yeast ceramide synthase
Structure of the yeast ceramide synthase
Ceramides are essential lipids involved in forming complex sphingolipids and acting as signaling molecules. They result fr...
Mechanism for Vipp1 spiral formation, ring biogenesis, and membrane repair
Mechanism for Vipp1 spiral formation, ring biogenesis, and membrane repair
The ESCRT-III-like protein Vipp1 couples filament polymerization with membrane remodeling. It assembles planar sheets as w...
Cryo-electron tomography reveals how COPII assembles on cargo-containing membranes
Cryo-electron tomography reveals how COPII assembles on cargo-containing membranes
Proteins traverse the eukaryotic secretory pathway through membrane trafficking between organelles. The coat protein compl...
Cryo-EM structure of the heteromeric TRPC1/TRPC4 channel
Cryo-EM structure of the heteromeric TRPC1/TRPC4 channel
Transient receptor potential (TRP) ion channels have a crucial role as cellular sensors, mediating diverse physical and ch...
Tubulin acetyltransferases access and modify the microtubule luminal K40 residue through anchors in taxane-binding pockets
Tubulin acetyltransferases access and modify the microtubule luminal K40 residue through anchors in taxane-binding pockets
Acetylation at α-tubulin K40 is the sole post-translational modification preferred to occur inside the lumen of hollo...
DNA methylation shapes the Polycomb landscape during the exit from naive pluripotency
DNA methylation shapes the Polycomb landscape during the exit from naive pluripotency
In mammals, 5-methylcytosine (5mC) and Polycomb repressive complex 2 (PRC2)-deposited histone 3 lysine 27 trimethylation (...
Mechanism of actin filament severing and capping by gelsolin
Mechanism of actin filament severing and capping by gelsolin
Gelsolin is the prototypical member of a family of Ca2+-activated F-actin severing and capping proteins. Here we report st...
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