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SHOCing RAF into action
SHOCing RAF into action
Recent structures of the three-way complex formed by the scaffold protein SHOC2, the small G protein M-RAS and protein pho...
Structure of the SHOC2–MRAS–PP1C complex provides insights into RAF activation and Noonan syndrome
Structure of the SHOC2–MRAS–PP1C complex provides insights into RAF activation and Noonan syndrome
SHOC2 acts as a strong synthetic lethal interactor with MEK inhibitors in multiple KRAS cancer cell lines. SHOC2 forms a h...
Focus and persistence: how Pol IV unblocks stalled DNA synthesis
Focus and persistence: how Pol IV unblocks stalled DNA synthesis
The mechanisms by which translesion DNA polymerases mediate DNA repair are incompletely understood. A new study shows that...
Compartmentalization of the replication fork by single-stranded DNA-binding protein regulates translesion synthesis
Compartmentalization of the replication fork by single-stranded DNA-binding protein regulates translesion synthesis
Processivity clamps tether DNA polymerases to DNA, allowing their access to the primer–template junction. In additio...
Chromatin found in space
Methods to map chromatin accessibility are used to probe the role of the chromatin landscape in shaping cellular states an...
The inner nuclear membrane protein Lem2 coordinates RNA degradation at the nuclear periphery
The inner nuclear membrane protein Lem2 coordinates RNA degradation at the nuclear periphery
Transcriptionally silent chromatin often localizes to the nuclear periphery. However, whether the nuclear envelope (NE) is...
Cryo-EM structure of disease-related prion fibrils provides insights into seeding barriers
Cryo-EM structure of disease-related prion fibrils provides insights into seeding barriers
One of the least understood aspects of prion diseases is the structure of infectious prion protein aggregates. Here we rep...
Visualizing maturation factor extraction from the nascent ribosome by the AAA-ATPase Drg1
Visualizing maturation factor extraction from the nascent ribosome by the AAA-ATPase Drg1
The AAA-ATPase Drg1 is a key factor in eukaryotic ribosome biogenesis that initiates cytoplasmic maturation of the large r...
Cohesin is required for long-range enhancer action at the Shh locus
Cohesin is required for long-range enhancer action at the Shh locus
The regulatory landscapes of developmental genes in mammals can be complex, with enhancers spread over many hundreds of ki...
Smc5/6 silences episomal transcription by a three-step function
Smc5/6 silences episomal transcription by a three-step function
In addition to its role in chromosome maintenance, the six-membered Smc5/6 complex functions as a restriction factor that ...
Matters of cell size
Cell size is a defining feature of cell type, and cells have dedicated mechanisms to keep their sizes carefully controlled...
Locked and loaded: T cells poised to target tumors
Locked and loaded: T cells poised to target tumors
Writing in Cell, Sušac et al. use a melanoma-specific peptide-loaded MHC to trap and isolate a corresponding TCR, and dete...
High-resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development
High-resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development
Emergence of SARS-CoV-2 coronavirus has led to millions of deaths globally. We present three high-resolution crystal struc...
Isoform-resolved mRNA profiling of ribosome load defines interplay of HIF and mTOR dysregulation in kidney cancer
Isoform-resolved mRNA profiling of ribosome load defines interplay of HIF and mTOR dysregulation in kidney cancer
Hypoxia inducible factor (HIF) and mammalian target of rapamycin (mTOR) pathways orchestrate responses to oxygen and nutri...
The DNA-damage kinase ATR activates the FANCD2-FANCI clamp by priming it for ubiquitination
The DNA-damage kinase ATR activates the FANCD2-FANCI clamp by priming it for ubiquitination
DNA interstrand cross-links are tumor-inducing lesions that block DNA replication and transcription. When cross-links are ...
Histone deacetylation primes self-propagation of heterochromatin domains to promote epigenetic inheritance
Histone deacetylation primes self-propagation of heterochromatin domains to promote epigenetic inheritance
Heterochromatin assembly, involving histone H3 lysine-9 methylation (H3K9me), is nucleated at specific genomic sites but c...
Structure of CRL7FBXW8 reveals coupling with CUL1–RBX1/ROC1 for multi-cullin-RING E3-catalyzed ubiquitin ligation
Structure of CRL7FBXW8 reveals coupling with CUL1–RBX1/ROC1 for multi-cullin-RING E3-catalyzed ubiquitin ligation
Most cullin-RING ubiquitin ligases (CRLs) form homologous assemblies between a neddylated cullin-RING catalytic module and...
Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR119
Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR119
Lysophosphatidylcholine (LPC) is an essential mediator in human lipid metabolism and is associated with a variety of disea...
Conformational buffering underlies functional selection in intrinsically disordered protein regions
Conformational buffering underlies functional selection in intrinsically disordered protein regions
Many disordered proteins conserve essential functions in the face of extensive sequence variation, making it challenging t...
How one molecule senses light and temperature
How one molecule senses light and temperature
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Structure of RAS signaling regulator complex reveals mechanism
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Whole-body CRISPR editing
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Unlatching a window into the molecular landscape of prion toxicity
Unlatching a window into the molecular landscape of prion toxicity
A study published in Nature Structural & Molecular Biology now unveils, at the atomic level, the initial mechanism...
Filling in the blanks: how the C-strand catches up to the G-strand at replicating telomeres using CST
Filling in the blanks: how the C-strand catches up to the G-strand at replicating telomeres using CST
CST is both an ssDNA-binding complex and a DNA Pol-α/primase cofactor that coordinates the switch from G-strand elong...
A conformational switch controlling the toxicity of the prion protein
A conformational switch controlling the toxicity of the prion protein
Prion infections cause conformational changes of the cellular prion protein (PrPC) and lead to progressive neurological im...
Gene regulation on extrachromosomal DNA
Gene regulation on extrachromosomal DNA
Oncogene amplification on extrachromosomal DNA (ecDNA) is prevalent in human cancer and is associated with poor outcomes. ...
The structure-specific endonuclease complex SLX4–XPF regulates Tus–Ter-induced homologous recombination
The structure-specific endonuclease complex SLX4–XPF regulates Tus–Ter-induced homologous recombination
Vertebrate replication forks arrested at interstrand DNA cross-links (ICLs) engage the Fanconi anemia pathway to incise ar...
Yeast PI31 inhibits the proteasome by a direct multisite mechanism
Yeast PI31 inhibits the proteasome by a direct multisite mechanism
Proteasome inhibitors are widely used as therapeutics and research tools, and typically target one of the three active sit...
Mechanism of client selection by the protein quality-control factor UBE2O
Mechanism of client selection by the protein quality-control factor UBE2O
The E2/E3 enzyme UBE2O ubiquitylates diverse clients to mediate important processes, including targeting unassembled ̵...
Proteasome-dependent truncation of the negative heterochromatin regulator Epe1 mediates antifungal resistance
Proteasome-dependent truncation of the negative heterochromatin regulator Epe1 mediates antifungal resistance
Epe1 histone demethylase restricts H3K9-methylation-dependent heterochromatin, preventing it from spreading over, and sile...