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The ribosome termination complex remodels release factor RF3 and ejects GDP
The ribosome termination complex remodels release factor RF3 and ejects GDP
Translation termination involves release factors RF1, RF2 and the GTPase RF3 that recycles RF1 and RF2 from the ribosome. ...
Cryo-EM structures of γ-TuRC reveal molecular insights into microtubule nucleation
Cryo-EM structures of γ-TuRC reveal molecular insights into microtubule nucleation
Microtubules within cells often have 13 protofilaments but are nucleated by multi-protein y-TuRCs complexes that display 1...
Obscure DNA sequences unveil a new cancer target
Obscure DNA sequences unveil a new cancer target
Curiosity-driven and fundamental discovery science must be justified in its importance to human health and translational p...
AlphaFold3 takes a step toward decoding molecular behavior and biological computation
AlphaFold3 takes a step toward decoding molecular behavior and biological computation
AlphaFold 3 represents a breakthrough in predicting the 3D structures of complexes directly from their sequences, offering...
VCP/p97-associated proteins are binders and debranching enzymes of K48–K63-branched ubiquitin chains
VCP/p97-associated proteins are binders and debranching enzymes of K48–K63-branched ubiquitin chains
Branched ubiquitin (Ub) chains constitute a sizable fraction of Ub polymers in human cells. Despite their abundance, our u...
Resolving chaperone-assisted protein folding on the ribosome at the peptide level
Resolving chaperone-assisted protein folding on the ribosome at the peptide level
Protein folding in vivo begins during synthesis on the ribosome and is modulated by molecular chaperones that engage the n...
A roadmap for ribosome assembly in human mitochondria
A roadmap for ribosome assembly in human mitochondria
Mitochondria contain dedicated ribosomes (mitoribosomes), which synthesize the mitochondrial-encoded core components of th...
The power of scientific collaborations and the future of structural biology
The idea of a scientific discovery is often linked to the eureka moment of a lone scientist, which then transforms our thi...
Structural basis of NEAT1 lncRNA maturation and menRNA instability
Structural basis of NEAT1 lncRNA maturation and menRNA instability
NEAT1 long noncoding RNA orchestrates paraspeckle assembly and impacts tumorigenesis, fertility and immunity. Its maturati...
The tRNA methyltransferase METTL6 requires seryl-tRNA synthetase for tRNASer targeting
The tRNA methyltransferase METTL6 requires seryl-tRNA synthetase for tRNASer targeting
Overexpression of the RNA methyltransferase METTL6 leads to increased proliferation and promotes cancer. Our cryo-electron...
Structural basis of tRNA recognition by the m3C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase
Structural basis of tRNA recognition by the m3C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase
Methylation of cytosine 32 in the anticodon loop of tRNAs to 3-methylcytosine (m3C) is crucial for cellular translation fi...
Structural and mechanistic basis for nucleosomal H2AK119 deubiquitination by single-subunit deubiquitinase USP16
Structural and mechanistic basis for nucleosomal H2AK119 deubiquitination by single-subunit deubiquitinase USP16
Epigenetic regulators have a crucial effect on gene expression based on their manipulation of histone modifications. Histo...
Control of mitophagy initiation and progression by the TBK1 adaptors NAP1 and SINTBAD
Control of mitophagy initiation and progression by the TBK1 adaptors NAP1 and SINTBAD
Mitophagy preserves overall mitochondrial fitness by selectively targeting damaged mitochondria for degradation. The regul...
Structure of the poxvirus core
Structure of the poxvirus core
Poxviruses range from deadly smallpox to attenuated vaccinia virus used in vaccines and oncolytic vectors. Despite their b...
Cryo-EM structures of Smc5/6 in multiple states reveal its assembly and functional mechanisms
Cryo-EM structures of Smc5/6 in multiple states reveal its assembly and functional mechanisms
Smc5/6 is a member of the eukaryotic structural maintenance of chromosomes (SMC) family of complexes with important roles ...
Multivalent interactions of the disordered regions of XLF and XRCC4 foster robust cellular NHEJ and drive the formation of ligation-boosting condensates in vitro
Multivalent interactions of the disordered regions of XLF and XRCC4 foster robust cellular NHEJ and drive the formation of ligation-boosting condensates in vitro
In mammalian cells, DNA double-strand breaks are predominantly repaired by non-homologous end joining (NHEJ). During repai...
Structures of synaptic vesicle protein 2A and 2B bound to anticonvulsants
Structures of synaptic vesicle protein 2A and 2B bound to anticonvulsants
Epilepsy is a common neurological disorder characterized by abnormal activity of neuronal networks, leading to seizures. T...
Structural basis for the dynamic chaperoning of disordered clients by Hsp90
Structural basis for the dynamic chaperoning of disordered clients by Hsp90
Molecular chaperone heat shock protein 90 (Hsp90) is a ubiquitous regulator that fine-tunes and remodels diverse client pr...
Author Correction: MYC phase separation selectively modulates the transcriptome
These authors contributed equally: Junjiao Yang, Chan-I Chung.Department of Pharmaceutical Chemistry, University of Califo...
The human ATAD5 has evolved unique structural elements to function exclusively as a PCNA unloader
The human ATAD5 has evolved unique structural elements to function exclusively as a PCNA unloader
Humans have three different proliferating cell nuclear antigen (PCNA) clamp-loading complexes: RFC and CTF18-RFC load PCNA...
Author Correction: Structural determinants for activity of the antidepressant vortioxetine at human and rodent 5-HT3 receptors
Uriel López-SánchezPresent address: Program in Cellular and Molecular Medicine, Boston Children’s Hospital and Department ...
Efficient selenium use by PRDX6 suppresses iron toxicity and ferroptosis
Efficient selenium use by PRDX6 suppresses iron toxicity and ferroptosis
An iron-induced ferroptosis screen revealed PRDX6 as a selenoprotein-synthesis factor. Loss of PRDX6 substantially decreas...
PRDX6 augments selenium utilization to limit iron toxicity and ferroptosis
PRDX6 augments selenium utilization to limit iron toxicity and ferroptosis
Ferroptosis is a form of regulated cell death induced by iron-dependent accumulation of lipid hydroperoxides. Selenoprotei...
Mechanistic insights into G-protein coupling with an agonist-bound G-protein-coupled receptor
Mechanistic insights into G-protein coupling with an agonist-bound G-protein-coupled receptor
G-protein-coupled receptors (GPCRs) activate heterotrimeric G proteins by promoting guanine nucleotide exchange. Here, we ...
The structure of the human 80S ribosome at 1.9 Å resolution reveals the molecular role of chemical modifications and ions in RNA
The structure of the human 80S ribosome at 1.9 Å resolution reveals the molecular role of chemical modifications and ions in RNA
The ribosomal RNA of the human protein synthesis machinery comprises numerous chemical modifications that are introduced d...
Chemical modifications, ions and water molecules in the sub-2 Å resolution structure of the human 80S ribosome
Chemical modifications, ions and water molecules in the sub-2 Å resolution structure of the human 80S ribosome
Using next-generation cryo-EM and mass spectrometry, we identified 235 chemical modifications in the sub-2 Å resoluti...
XIST dampens X chromosome activity in a SPEN-dependent manner during early human development
XIST dampens X chromosome activity in a SPEN-dependent manner during early human development
XIST (X-inactive specific transcript) long noncoding RNA (lncRNA) is responsible for X chromosome inactivation (XCI) in pl...
Mini-heterochromatin domains constrain the cis-regulatory impact of SVA transposons in human brain development and disease
Mini-heterochromatin domains constrain the cis-regulatory impact of SVA transposons in human brain development and disease
SVA (SINE (short interspersed nuclear element)–VNTR (variable number of tandem repeats)–Alu) retrotransposons ...
Allosteric competition and inhibition in AMPA receptors
Allosteric competition and inhibition in AMPA receptors
Excitatory neurotransmission is principally mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-s...
ATG16L1 induces the formation of phagophore-like membrane cups
ATG16L1 induces the formation of phagophore-like membrane cups
The hallmark of non-selective autophagy is the formation of cup-shaped phagophores that capture bulk cytoplasm. The proces...
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