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Structures of aberrant spliceosome intermediates on their way to disassembly
Structures of aberrant spliceosome intermediates on their way to disassembly
Intron removal during pre-mRNA splicing is of extraordinary complexity and its disruption causes a vast number of genetic ...
The structure and function of the ghrelin receptor coding for drug actions
The structure and function of the ghrelin receptor coding for drug actions
Drugs targeting the ghrelin receptor hold therapeutic potential in anorexia, obesity and diabetes. However, developing eff...
Fascin structural plasticity mediates flexible actin bundle construction
Fascin structural plasticity mediates flexible actin bundle construction
Fascin cross-links actin filaments (F-actin) into bundles that support tubular membrane protrusions including filopodia an...
Temporal and regional X-linked gene reactivation in the mouse germline reveals site-specific retention of epigenetic silencing
Temporal and regional X-linked gene reactivation in the mouse germline reveals site-specific retention of epigenetic silencing
Random X-chromosome inactivation is a hallmark of female mammalian somatic cells. This epigenetic mechanism, mediated by t...
Botulinum neurotoxins exploit host digestive proteases to boost their oral toxicity via activating OrfXs/P47
Botulinum neurotoxins exploit host digestive proteases to boost their oral toxicity via activating OrfXs/P47
Botulinum neurotoxins (BoNTs) rank among the most potent toxins and many of them are produced by bacteria carrying the orf...
Cryo-EM reveals cholesterol binding in the lysosomal GPCR-like protein LYCHOS
Cryo-EM reveals cholesterol binding in the lysosomal GPCR-like protein LYCHOS
Cholesterol plays a pivotal role in modulating the activity of mechanistic target of rapamycin complex 1 (mTOR1), thereby ...
ERK–USP9X-coupled regulation of thymidine kinase 1 promotes both its enzyme activity-dependent and its enzyme activity-independent functions for tumor growth
ERK–USP9X-coupled regulation of thymidine kinase 1 promotes both its enzyme activity-dependent and its enzyme activity-independent functions for tumor growth
Thymidine kinase 1 (TK1), a crucial enzyme in DNA synthesis, is highly expressed in various cancers. However, the mechanis...
Molecular architecture of human LYCHOS involved in lysosomal cholesterol signaling
Molecular architecture of human LYCHOS involved in lysosomal cholesterol signaling
Lysosomal membrane protein LYCHOS (lysosomal cholesterol signaling) translates cholesterol abundance to mammalian target o...
Dynamic PRC1–CBX8 stabilizes a porous structure of chromatin condensates
Dynamic PRC1–CBX8 stabilizes a porous structure of chromatin condensates
The compaction of chromatin is a prevalent paradigm in gene repression. Chromatin compaction is commonly thought to repres...
The translational landscape of HIV-1 infected cells reveals key gene regulatory principles
The translational landscape of HIV-1 infected cells reveals key gene regulatory principles
Human immunodeficiency virus-1 (HIV-1) uses a number of strategies to modulate viral and host gene expression during its l...
Maternal ELL3 loss-of-function leads to oocyte aneuploidy and early miscarriage
Maternal ELL3 loss-of-function leads to oocyte aneuploidy and early miscarriage
Up to an estimated 10% of women experience miscarriage in their lifetimes. Embryonic aneuploidy is a leading cause for mis...
Single-molecule analysis of transcription activation: dynamics of SAGA coactivator recruitment
Single-molecule analysis of transcription activation: dynamics of SAGA coactivator recruitment
Transcription activators are said to stimulate gene expression by ‘recruiting’ coactivators, yet this vague te...
Molecular basis of neurosteroid and anticonvulsant regulation of TRPM3
Molecular basis of neurosteroid and anticonvulsant regulation of TRPM3
Transient receptor potential channel subfamily M member 3 (TRPM3) is a Ca2+-permeable cation channel activated by the neur...
Ribosomal A-site interactions with near-cognate tRNAs drive stop codon readthrough
Ribosomal A-site interactions with near-cognate tRNAs drive stop codon readthrough
Transfer RNAs (tRNAs) serve as a dictionary for the ribosome translating the genetic message from mRNA into a polypeptide ...
Binding mechanism and antagonism of the vesicular acetylcholine transporter VAChT
Binding mechanism and antagonism of the vesicular acetylcholine transporter VAChT
The vesicular acetylcholine transporter (VAChT) has a pivotal role in packaging and transporting acetylcholine for exocyto...
Structural basis for the inhibition of PRC2 by active transcription histone posttranslational modifications
Structural basis for the inhibition of PRC2 by active transcription histone posttranslational modifications
Polycomb repressive complex 2 (PRC2) trimethylates histone H3 on K27 (H3K27me3) leading to gene silencing that is essentia...
Importance of an N-terminal structural switch in the distinction between small RNA-bound and free ARGONAUTE
Importance of an N-terminal structural switch in the distinction between small RNA-bound and free ARGONAUTE
ARGONAUTE (AGO) proteins bind to small non-coding RNAs to form RNA-induced silencing complexes. In the RNA-bound state, AG...
RapA opens the RNA polymerase clamp to disrupt post-termination complexes and prevent cytotoxic R-loop formation
RapA opens the RNA polymerase clamp to disrupt post-termination complexes and prevent cytotoxic R-loop formation
Following transcript release during intrinsic termination, Escherichia coli RNA polymerase (RNAP) often remains associated...
Inherent asymmetry of Rpd3S coordinates its nucleosome engagement and association with elongating RNA polymerase II
Inherent asymmetry of Rpd3S coordinates its nucleosome engagement and association with elongating RNA polymerase II
The Rpd3S histone deacetylase complex has a crucial role in genomic integrity by deacetylating transcribed nucleosomes fol...
DARPin-induced reactivation of p53 in HPV-positive cells
DARPin-induced reactivation of p53 in HPV-positive cells
Infection of cells with high-risk strains of the human papillomavirus (HPV) causes cancer in various types of epithelial t...
Capturing eukaryotic ribosome dynamics in situ at high resolution
Capturing eukaryotic ribosome dynamics in situ at high resolution
Many protein complexes are highly dynamic in cells; thus, characterizing their conformational changes in cells is crucial ...
Structure and catalytic mechanism of exogenous fatty acid recycling by AasS, a versatile acyl-ACP synthetase
Structure and catalytic mechanism of exogenous fatty acid recycling by AasS, a versatile acyl-ACP synthetase
Fatty acids (FAs) are essential building blocks for all the domains of life, of which bacterial de novo synthesis, called ...
A multivalent engagement of ENL with MOZ
A multivalent engagement of ENL with MOZ
The epigenetic cofactor ENL (eleven-nineteen-leukemia) and the acetyltransferase MOZ (monocytic leukemia zinc finger) have...
ATM and IRAK1 orchestrate two distinct mechanisms of NF-κB activation in response to DNA damage
ATM and IRAK1 orchestrate two distinct mechanisms of NF-κB activation in response to DNA damage
DNA damage in cells induces the expression of inflammatory genes. However, the mechanism by which cells initiate an innate...
Interfacial water confers transcription factors with dinucleotide specificity
Interfacial water confers transcription factors with dinucleotide specificity
Transcription factors (TFs) recognize specific bases within their DNA-binding motifs, with each base contributing nearly i...
Intronic variant increases Parkinson disease risk by disrupting branchpoint sequence
Intronic variant increases Parkinson disease risk by disrupting branchpoint sequence
A genetic variant specific to people of African ancestry increases the risk of neurodegenerative diseases, such as Parkins...
Molecular basis of human nuclear and mitochondrial tRNA 3′ processing
Molecular basis of human nuclear and mitochondrial tRNA 3′ processing
Eukaryotic transfer RNA (tRNA) precursors undergo sequential processing steps to become mature tRNAs. In humans, ELAC2 car...
KIF1C activates and extends dynein movement through the FHF cargo adapter
KIF1C activates and extends dynein movement through the FHF cargo adapter
Cellular cargos move bidirectionally on microtubules by recruiting opposite polarity motors dynein and kinesin. These moto...
Insights into phosphate homeostasis regulation by XPR1
Insights into phosphate homeostasis regulation by XPR1
XPR1 is the only annotated phosphate exporter protein in humans. Recent studies provide mechanistic clues to its cellular ...
Targeted degradation of membrane proteins
Targeted degradation of membrane proteins
Targeted protein degradation is a promising drug discovery approach. A study now describes transferrin receptor targeting ...
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