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Efficacy and Safety of CDK4/6 Inhibitors: A Focus on HR+/HER2− Early Breast Cancer
Efficacy and Safety of CDK4/6 Inhibitors: A Focus on HR+/HER2− Early Breast Cancer
Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) have revolutionized the treatment of hormone-receptor positive (HR+), HER...
Long-Term Self-Administered Outpatient Parenteral Antimicrobial Therapy in the Treatment of Tuberculosis
Long-Term Self-Administered Outpatient Parenteral Antimicrobial Therapy in the Treatment of Tuberculosis
To investigate the safety profiles and clinical outcomes in a continuous cohort of tuberculosis (TB) patients from a clini...
Tuberculosis Preventive Treatment in High TB-Burden Settings: A State-of-the-Art Review
Tuberculosis Preventive Treatment in High TB-Burden Settings: A State-of-the-Art Review
Tuberculosis (TB) is the leading cause of death from a single infectious agent. The burden is highest in some low- and mid...
Arimoclomol: First Approval
Arimoclomol: First Approval
Arimoclomol (MIPLYFFA™), an oral small molecule that crosses the blood brain barrier and is thought to upregulate CL...
Marstacimab: First Approval
Marstacimab: First Approval
Marstacimab (marstacimab-hncq; HYMPAVZI™) is a subcutaneously administered human monoclonal immunoglobulin G1 antibo...
Xanomeline/Trospium Chloride: First Approval
Xanomeline/Trospium Chloride: First Approval
Xanomeline/trospium chloride (COBENFY™), formerly KarXT, is a first-in-class, oral, fixed-dose muscarinic agonist/an...
Aligning Large Language Models with Humans: A Comprehensive Survey of ChatGPT’s Aptitude in Pharmacology
Aligning Large Language Models with Humans: A Comprehensive Survey of ChatGPT’s Aptitude in Pharmacology
Due to the lack of a comprehensive pharmacology test set, evaluating the potential and value of large language models (LLM...
Xeligekimab: First Approval
Xeligekimab: First Approval
Xeligekimab (Jinlixi®) is a recombinant human interleukin (IL)-17A-neutralizing immunoglobulin (Ig)G4 monoclonal anti...
Effectiveness of Interventions to Reduce Opioid Use After Orthopaedic Surgery: A Systematic Review of Randomised Controlled Trials
Effectiveness of Interventions to Reduce Opioid Use After Orthopaedic Surgery: A Systematic Review of Randomised Controlled Trials
The prescribing of opioids to patients for postoperative pain can lead to persistent opioid use. This review investigated ...
Fulzerasib: First Approval
Fulzerasib: First Approval
Fulzerasib (Dupert®; Innovent Biologics/GenFleet Therapeutics) is an orally active small molecule inhibitor of the KR...
Seladelpar: First Approval
Seladelpar: First Approval
Seladelpar (LIVDELZI®) is an oral delpar [i.e. a selective peroxisome proliferator-activated receptor (PPAR)δ ag...
Odronextamab: First Approval
Odronextamab: First Approval
Odronextamab (Ordspono™), a CD20xCD3 bispecific antibody, is being developed by Regeneron Pharmaceuticals for the tr...
Enlonstobart: First Approval
Enlonstobart: First Approval
Enlonstobart (Enshuxing®), a recombinant, fully humanised immunoglobulin G4 monoclonal antibody targeted against prog...
Axatilimab: First Approval
Axatilimab: First Approval
Axatilimab (NIKTIMVO™; axatilimab-csfr), an anti-colony-stimulating Factor 1 Receptor (CSF-1R) humanized IgG4 (κ...
Immunogenicity of Therapeutic Antibodies Used for Inflammatory Bowel Disease: Treatment and Clinical Considerations
Immunogenicity of Therapeutic Antibodies Used for Inflammatory Bowel Disease: Treatment and Clinical Considerations
The introduction of tumor necrosis factor inhibitors has led to a paradigm shift in the management of inflammatory bowel d...
The Utilization of the Accelerated Approval Pathway in Oncology: A Case Study of Pembrolizumab
The Utilization of the Accelerated Approval Pathway in Oncology: A Case Study of Pembrolizumab
The accelerated approval (AA) pathway was established by the United States Food and Drug Administration (FDA) to provide e...
Moderate-Intensity Statin Plus Ezetimibe: Time to Rethink it as an Optimal Initial Lipid-Lowering Strategy
Moderate-Intensity Statin Plus Ezetimibe: Time to Rethink it as an Optimal Initial Lipid-Lowering Strategy
Achievement of low-density lipoprotein cholesterol (LDL-C) targets is crucial for the prevention of cardiovascular disease...
Efficacy and Safety of Sovateltide in Patients with Acute Cerebral Ischaemic Stroke: A Randomised, Double-Blind, Placebo-Controlled, Multicentre, Phase III Clinical Trial
Efficacy and Safety of Sovateltide in Patients with Acute Cerebral Ischaemic Stroke: A Randomised, Double-Blind, Placebo-Controlled, Multicentre, Phase III Clinical Trial
Sovateltide (Tycamzzi™), an endothelin-B (ET-B) receptor agonist, increases cerebral blood flow, has anti-apoptotic ...
Vunakizumab: First Approval
Vunakizumab: First Approval
Vunakizumab (安达静®) is a subcutaneous (SC) recombinant anti-interleukin (IL)-17A humanized monocl...
2024 Recommendations on the Optimal Use of Lipid-Lowering Therapy in Established Atherosclerotic Cardiovascular Disease and Following Acute Coronary Syndromes: A Position Paper of the International Lipid Expert Panel (ILEP)
2024 Recommendations on the Optimal Use of Lipid-Lowering Therapy in Established Atherosclerotic Cardiovascular Disease and Following Acute Coronary Syndromes: A Position Paper of the International Lipid Expert Panel (ILEP)
Atherosclerotic cardiovascular disease (ASCVD) and consequent acute coronary syndromes (ACS) are substantial contributors ...
Update on Mpox Management: Epidemiology, Vaccines and Therapeutics, and Regulatory Changes
Update on Mpox Management: Epidemiology, Vaccines and Therapeutics, and Regulatory Changes
Mpox, caused by the monkeypox virus (MPXV), is categorized into two primary clades: Clade I and Clade II, with notable out...
The Challenge of Treating Infections Caused by Metallo‐β‐Lactamase–Producing Gram-Negative Bacteria: A Narrative Review
The Challenge of Treating Infections Caused by Metallo‐β‐Lactamase–Producing Gram-Negative Bacteria: A Narrative Review
Gram-negative multidrug-resistant (MDR) bacteria, including Enterobacterales, Acinetobacter baumannii, and Pseudomonas aer...
How Psychedelics Modulate Multiple Memory Mechanisms in Posttraumatic Stress Disorder
How Psychedelics Modulate Multiple Memory Mechanisms in Posttraumatic Stress Disorder
Posttraumatic stress disorder (PTSD) is a psychiatric disorder with defining abnormalities in memory, and psychedelics may...
A Meta-analysis Exploring the Efficacy of Neuropathic Pain Medication for Low Back Pain or Spine-Related Leg Pain: Is Efficacy Dependent on the Presence of Neuropathic Pain?
A Meta-analysis Exploring the Efficacy of Neuropathic Pain Medication for Low Back Pain or Spine-Related Leg Pain: Is Efficacy Dependent on the Presence of Neuropathic Pain?
Highly variable pain mechanisms in people with low back pain or spine-related leg pain might contribute to inefficacy of n...
Trientine Tetrahydrochloride, From Bench to Bedside: A Narrative Review
Trientine Tetrahydrochloride, From Bench to Bedside: A Narrative Review
Trientine tetrahydrochloride (TETA-4HCl, Cuvrior®) is a copper chelating agent with the active moiety triethylenetetr...
Exploring Novel Pharmacotherapy Candidates for Cannabis Use Disorder: Uncovering Promising Agents on the Horizon by Mechanism of Action
Exploring Novel Pharmacotherapy Candidates for Cannabis Use Disorder: Uncovering Promising Agents on the Horizon by Mechanism of Action
With rapid expansion of cannabis legalization worldwide, rates of cannabis use and cannabis use disorder (CUD) are increas...
Difficult-to-Treat Axial Spondyloarthritis: A New Challenge
Difficult-to-Treat Axial Spondyloarthritis: A New Challenge
Axial spondyloarthritis is a common form of chronic inflammatory rheumatic disease in adults, the treatment of which is ba...
Vorasidenib: First Approval
Vorasidenib: First Approval
Vorasidenib (VORANIGO®; Servier) is an orally administered, first-in-class, highly brain-penetrant dual inhibitor of ...
Orexin Receptor Antagonists for the Prevention and Treatment of Alzheimer’s Disease and Associated Sleep Disorders
Orexin Receptor Antagonists for the Prevention and Treatment of Alzheimer’s Disease and Associated Sleep Disorders
Orexins/hypocretins are neuropeptides produced by the hypothalamic neurons, binding two G-protein coupled receptors (orexi...
Asthma and Cardiovascular Diseases: Navigating Mutual Pharmacological Interferences
Asthma and Cardiovascular Diseases: Navigating Mutual Pharmacological Interferences
Asthma and cardiovascular disease (CVD) often co-exist. When a patient has both conditions, management requires an approac...
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