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Immunogenicity of Therapeutic Antibodies Used for Inflammatory Bowel Disease: Treatment and Clinical Considerations
Immunogenicity of Therapeutic Antibodies Used for Inflammatory Bowel Disease: Treatment and Clinical Considerations
The introduction of tumor necrosis factor inhibitors has led to a paradigm shift in the management of inflammatory bowel d...
The Utilization of the Accelerated Approval Pathway in Oncology: A Case Study of Pembrolizumab
The Utilization of the Accelerated Approval Pathway in Oncology: A Case Study of Pembrolizumab
The accelerated approval (AA) pathway was established by the United States Food and Drug Administration (FDA) to provide e...
Moderate-Intensity Statin Plus Ezetimibe: Time to Rethink it as an Optimal Initial Lipid-Lowering Strategy
Moderate-Intensity Statin Plus Ezetimibe: Time to Rethink it as an Optimal Initial Lipid-Lowering Strategy
Achievement of low-density lipoprotein cholesterol (LDL-C) targets is crucial for the prevention of cardiovascular disease...
Efficacy and Safety of Sovateltide in Patients with Acute Cerebral Ischaemic Stroke: A Randomised, Double-Blind, Placebo-Controlled, Multicentre, Phase III Clinical Trial
Efficacy and Safety of Sovateltide in Patients with Acute Cerebral Ischaemic Stroke: A Randomised, Double-Blind, Placebo-Controlled, Multicentre, Phase III Clinical Trial
Sovateltide (Tycamzzi™), an endothelin-B (ET-B) receptor agonist, increases cerebral blood flow, has anti-apoptotic ...
Vunakizumab: First Approval
Vunakizumab: First Approval
Vunakizumab (安达静®) is a subcutaneous (SC) recombinant anti-interleukin (IL)-17A humanized monocl...
2024 Recommendations on the Optimal Use of Lipid-Lowering Therapy in Established Atherosclerotic Cardiovascular Disease and Following Acute Coronary Syndromes: A Position Paper of the International Lipid Expert Panel (ILEP)
2024 Recommendations on the Optimal Use of Lipid-Lowering Therapy in Established Atherosclerotic Cardiovascular Disease and Following Acute Coronary Syndromes: A Position Paper of the International Lipid Expert Panel (ILEP)
Atherosclerotic cardiovascular disease (ASCVD) and consequent acute coronary syndromes (ACS) are substantial contributors ...
Update on Mpox Management: Epidemiology, Vaccines and Therapeutics, and Regulatory Changes
Update on Mpox Management: Epidemiology, Vaccines and Therapeutics, and Regulatory Changes
Mpox, caused by the monkeypox virus (MPXV), is categorized into two primary clades: Clade I and Clade II, with notable out...
The Challenge of Treating Infections Caused by Metallo‐β‐Lactamase–Producing Gram-Negative Bacteria: A Narrative Review
The Challenge of Treating Infections Caused by Metallo‐β‐Lactamase–Producing Gram-Negative Bacteria: A Narrative Review
Gram-negative multidrug-resistant (MDR) bacteria, including Enterobacterales, Acinetobacter baumannii, and Pseudomonas aer...
How Psychedelics Modulate Multiple Memory Mechanisms in Posttraumatic Stress Disorder
How Psychedelics Modulate Multiple Memory Mechanisms in Posttraumatic Stress Disorder
Posttraumatic stress disorder (PTSD) is a psychiatric disorder with defining abnormalities in memory, and psychedelics may...
A Meta-analysis Exploring the Efficacy of Neuropathic Pain Medication for Low Back Pain or Spine-Related Leg Pain: Is Efficacy Dependent on the Presence of Neuropathic Pain?
A Meta-analysis Exploring the Efficacy of Neuropathic Pain Medication for Low Back Pain or Spine-Related Leg Pain: Is Efficacy Dependent on the Presence of Neuropathic Pain?
Highly variable pain mechanisms in people with low back pain or spine-related leg pain might contribute to inefficacy of n...
Trientine Tetrahydrochloride, From Bench to Bedside: A Narrative Review
Trientine Tetrahydrochloride, From Bench to Bedside: A Narrative Review
Trientine tetrahydrochloride (TETA-4HCl, Cuvrior®) is a copper chelating agent with the active moiety triethylenetetr...
Exploring Novel Pharmacotherapy Candidates for Cannabis Use Disorder: Uncovering Promising Agents on the Horizon by Mechanism of Action
Exploring Novel Pharmacotherapy Candidates for Cannabis Use Disorder: Uncovering Promising Agents on the Horizon by Mechanism of Action
With rapid expansion of cannabis legalization worldwide, rates of cannabis use and cannabis use disorder (CUD) are increas...
Difficult-to-Treat Axial Spondyloarthritis: A New Challenge
Difficult-to-Treat Axial Spondyloarthritis: A New Challenge
Axial spondyloarthritis is a common form of chronic inflammatory rheumatic disease in adults, the treatment of which is ba...
Vorasidenib: First Approval
Vorasidenib: First Approval
Vorasidenib (VORANIGO®; Servier) is an orally administered, first-in-class, highly brain-penetrant dual inhibitor of ...
Orexin Receptor Antagonists for the Prevention and Treatment of Alzheimer’s Disease and Associated Sleep Disorders
Orexin Receptor Antagonists for the Prevention and Treatment of Alzheimer’s Disease and Associated Sleep Disorders
Orexins/hypocretins are neuropeptides produced by the hypothalamic neurons, binding two G-protein coupled receptors (orexi...
Asthma and Cardiovascular Diseases: Navigating Mutual Pharmacological Interferences
Asthma and Cardiovascular Diseases: Navigating Mutual Pharmacological Interferences
Asthma and cardiovascular disease (CVD) often co-exist. When a patient has both conditions, management requires an approac...
Targeting the Sphingosine-1-Phosphate Pathway: New Opportunities in Inflammatory Bowel Disease Management
Targeting the Sphingosine-1-Phosphate Pathway: New Opportunities in Inflammatory Bowel Disease Management
Inflammatory bowel diseases (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC) are chronic immune-med...
GLP-1 Receptor Agonists and SGLT2 Inhibitors in Type 2 Diabetes: Pleiotropic Cardiometabolic Effects and Add-on Value of a Combined Therapy
GLP-1 Receptor Agonists and SGLT2 Inhibitors in Type 2 Diabetes: Pleiotropic Cardiometabolic Effects and Add-on Value of a Combined Therapy
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter 2 inhibitors (SGLT2is) have proven e...
Renin-Angiotensin-Aldosterone System Modulators in Adults with Hypertension: A Network Meta-Analysis of Randomized Controlled Trials
Renin-Angiotensin-Aldosterone System Modulators in Adults with Hypertension: A Network Meta-Analysis of Randomized Controlled Trials
Although a range of renin-angiotensin-aldosterone system (RAAS) modulators are available for blood pressure lowering, the ...
Golidocitinib: First Approval
Golidocitinib: First Approval
Golidocitinib (高瑞哲®) is an oral, potent, selective Janus kinase 1 (JAK1) inhibitor being develop...
Dose Individualisation of Antimicrobials from a Pharmacometric Standpoint: The Current Landscape
Dose Individualisation of Antimicrobials from a Pharmacometric Standpoint: The Current Landscape
Successful antimicrobial therapy depends on achieving optimal drug concentrations within individual patients. Inter-patien...
Donanemab: First Approval
Donanemab: First Approval
Donanemab (donanemab-azbt; KisunlaTM) is an amyloid β-directed antibody developed by Eli Lilly and Company for the tr...
Impact of CYP2C19 Genotype Status on Clinical Outcomes in Patients with Symptomatic Coronary Artery Disease, Stroke, and Peripheral Arterial Disease: A Systematic Review and Meta-Analysis
Impact of CYP2C19 Genotype Status on Clinical Outcomes in Patients with Symptomatic Coronary Artery Disease, Stroke, and Peripheral Arterial Disease: A Systematic Review and Meta-Analysis
Clopidogrel is widely used for the secondary prevention of atherothrombotic events in patients with coronary artery diseas...
Long-Term Safety and Efficacy Evaluation of Travoprost Intracameral Implant Based on Pooled Analyses from Two Phase III Trials
Long-Term Safety and Efficacy Evaluation of Travoprost Intracameral Implant Based on Pooled Analyses from Two Phase III Trials
The purpose of this study was to conduct and interpret a pooled 12-month analysis of two prospective, multi-center, random...
Cefepime–Taniborbactam: A Novel Cephalosporin/β-Lactamase Inhibitor Combination
Cefepime–Taniborbactam: A Novel Cephalosporin/β-Lactamase Inhibitor Combination
Taniborbactam (formerly known as VNRX-5133) is a novel bicyclic boronate β-lactamase inhibitor of serine β-lacta...
Ensifentrine: First Approval
Ensifentrine: First Approval
Ensifentrine, an inhaled, selective phosphodiesterase (PDE) 3 and PDE4 inhibitor, is being developed by Verona Pharma plc ...
Imetelstat: First Approval
Imetelstat: First Approval
Imetelstat (RYTELO™), an oligonucleotide telomerase inhibitor, is being developed by Geron Corporation for the treat...
Correction: Tegileridine: First Approval
Correction: Tegileridine: First Approval
Share this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a sh...
Anticoagulation in Chronic Kidney Disease
Anticoagulation in Chronic Kidney Disease
The nuanced landscape of anticoagulation therapy in patients with chronic kidney disease (CKD) presents a formidable chall...
Bone Fragility in Diabetes and its Management: A Narrative Review
Bone Fragility in Diabetes and its Management: A Narrative Review
Bone fragility is a serious yet under-recognised complication of diabetes mellitus (DM) that is associated with significan...
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