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cGAS/STING in skin melanoma: from molecular mechanisms to therapeutics
cGAS/STING in skin melanoma: from molecular mechanisms to therapeutics
Melanoma, recognized as the most aggressive type of skin cancer, has experienced a notable increase in cases, especially w...
Exercise-conditioned plasma ameliorates postoperative cognitive dysfunction by activating hippocampal cholinergic circuit and enhancing BDNF/TrkB signaling
Exercise-conditioned plasma ameliorates postoperative cognitive dysfunction by activating hippocampal cholinergic circuit and enhancing BDNF/TrkB signaling
Postoperative cognitive dysfunction (POCD) is a prevalent complication following anesthesia and surgery, particularly in t...
miR-23b-3p, miR-126-3p and GAS5 delivered by extracellular vesicles inhibit breast cancer xenografts in zebrafish
miR-23b-3p, miR-126-3p and GAS5 delivered by extracellular vesicles inhibit breast cancer xenografts in zebrafish
Extracellular vesicles (EVs) are a group of nanoscale cell-derived membranous structures secreted by all cell types, conta...
USP11 promotes lipogenesis and tumorigenesis by regulating SREBF1 stability in hepatocellular carcinoma
USP11 promotes lipogenesis and tumorigenesis by regulating SREBF1 stability in hepatocellular carcinoma
The relationship between hepatocellular carcinoma (HCC) metastasis and cancer metabolism reprogramming is becoming increas...
MyD88 protein destabilization mitigates NF-κB-dependent protection against macrophage apoptosis
MyD88 protein destabilization mitigates NF-κB-dependent protection against macrophage apoptosis
Various signaling pathways are essential for both the innate immune response and the maintenance of cell homeostasis, requ...
A signaling pathway map of plasminogen activator inhibitor-1 (PAI-1/SERPINE-1): a review of an innovative frontier in molecular aging and cellular senescence
A signaling pathway map of plasminogen activator inhibitor-1 (PAI-1/SERPINE-1): a review of an innovative frontier in molecular aging and cellular senescence
Plasminogen activator inhibitor-1 (PAI-1) is a vital regulator of the fibrinolytic mechanism and has been intrica...
The role of pyroptosis in cancer: key components and therapeutic potential
The role of pyroptosis in cancer: key components and therapeutic potential
Pyroptosis is a lytic and inflammatory form of gasdermin protein-mediated programmed cell death that is typically initiate...
Role of the CTCF/p300 axis in osteochondrogenic-like differentiation of polyploid giant cancer cells with daughter cells
Role of the CTCF/p300 axis in osteochondrogenic-like differentiation of polyploid giant cancer cells with daughter cells
Polyploid giant cancer cells (PGCCs) have properties of cancer stem cells (CSCs). PGCCs with daughter cells (PDCs) undergo...
Exploring the role of Fusobacterium nucleatum in colorectal cancer: implications for tumor proliferation and chemoresistance
Exploring the role of Fusobacterium nucleatum in colorectal cancer: implications for tumor proliferation and chemoresistance
Fusobacterium nucleatum (Fn) has been extensively studied for its connection to colorectal cancer (CRC) and its potential ...
Evidence that CRISPR-Cas9 Y537S-mutant expressing breast cancer cells activate Yes-associated protein 1 to driving the conversion of normal fibroblasts into cancer-associated fibroblasts
Evidence that CRISPR-Cas9 Y537S-mutant expressing breast cancer cells activate Yes-associated protein 1 to driving the conversion of normal fibroblasts into cancer-associated fibroblasts
Endocrine therapy (ET) has improved the clinical outcomes of Estrogen receptor alpha-positive (ERɑ +) breast ca...
Novel Ser74 of NF-κB/IκBα phosphorylated by MAPK/ERK regulates temperature adaptation in oysters
Novel Ser74 of NF-κB/IκBα phosphorylated by MAPK/ERK regulates temperature adaptation in oysters
Phosphorylation of Ser32 and Ser36 controls the degradation of IκBα is the conserved cascade mechanisms of immun...
Emerging roles and biomarker potential of WNT6 in human cancers
Emerging roles and biomarker potential of WNT6 in human cancers
The WNT6 ligand is a well-known activator of the WNT signaling pathway, considered a vital player in several important phy...
IGFBP7 is a key component of the senescence-associated secretory phenotype (SASP) that induces senescence in healthy cells by modulating the insulin, IGF, and activin A pathways
IGFBP7 is a key component of the senescence-associated secretory phenotype (SASP) that induces senescence in healthy cells by modulating the insulin, IGF, and activin A pathways
Senescent cells exert their effects through the release of various factors, collectively referred to as the senescence-ass...
NAD+ enhancers as therapeutic agents in the cardiorenal axis
NAD+ enhancers as therapeutic agents in the cardiorenal axis
Cardiorenal diseases represent a complex interplay between heart failure and renal dysfunction, being clinically classifie...
Cell damage shifts the microRNA content of small extracellular vesicles into a Toll-like receptor 7-activating cargo capable to propagate inflammation and immunity
Cell damage shifts the microRNA content of small extracellular vesicles into a Toll-like receptor 7-activating cargo capable to propagate inflammation and immunity
The physiological relevance of cell-to-cell communication mediated by small extracellular vesicle-encapsulated microRNAs (...
RNF13 protects neurons against ischemia-reperfusion injury via stabilizing p62-mediated Nrf2/HO-1 signaling pathway
RNF13 protects neurons against ischemia-reperfusion injury via stabilizing p62-mediated Nrf2/HO-1 signaling pathway
Cerebral ischemia/reperfusion injury (CIRI), a common, universal clinical problem that costs a large proportion o...
Inhibition of SGLT2 protects podocytes in diabetic kidney disease by rebalancing mitochondria-associated endoplasmic reticulum membranes
Inhibition of SGLT2 protects podocytes in diabetic kidney disease by rebalancing mitochondria-associated endoplasmic reticulum membranes
Sodium-glucose cotransporter 2 (SGLT2) inhibitors have changed the therapeutic landscape for diabetic kidney disease (DKD)...
Regulation of ADAM10 activity through microdomain-dependent intracellular calcium changes
Regulation of ADAM10 activity through microdomain-dependent intracellular calcium changes
A disintegrin and metalloproteinases (ADAMs) are transmembrane proteases that cleave other proteins close to the surface i...
Atomoxetine suppresses radioresistance in glioblastoma via circATIC/miR-520d-5p/Notch2-Hey1 axis
Atomoxetine suppresses radioresistance in glioblastoma via circATIC/miR-520d-5p/Notch2-Hey1 axis
Resistance acquired after radiotherapy is directly related to the failure of various cancer treatments, including GBM. Bec...
Breast cancer cells utilize T3 to trigger proliferation through cellular Ca2+ modulation
Breast cancer cells utilize T3 to trigger proliferation through cellular Ca2+ modulation
High levels of thyroid hormones are linked to increased risk and advanced stages of breast cancer. Our previous work demon...
PIM1 kinase and its diverse substrate in solid tumors
PIM1 kinase and its diverse substrate in solid tumors
The PIM kinase family, consisting of PIM1, PIM2, and PIM3, is a group of serine/threonine protein kinases crucial for cell...
A non-catalytic role of IPMK is required for PLCγ1 activation in T cell receptor signaling by stabilizing the PLCγ1-Sam68 complex
A non-catalytic role of IPMK is required for PLCγ1 activation in T cell receptor signaling by stabilizing the PLCγ1-Sam68 complex
Phospholipase C gamma 1 (PLCγ1) is an important mediator of the T cell receptor (TCR) and growth factor signaling. PL...
Refractory testicular germ cell tumors are highly sensitive to the targeting of polycomb pathway demethylases KDM6A and KDM6B
Refractory testicular germ cell tumors are highly sensitive to the targeting of polycomb pathway demethylases KDM6A and KDM6B
Testicular germ cell tumors (TGCTs) can be treated with cisplatin-based therapy. However, a clinically significant number ...
Exosome-based immunotherapy as an innovative therapeutic approach in melanoma
Exosome-based immunotherapy as an innovative therapeutic approach in melanoma
The malignant form of melanoma is one of the deadliest human cancers that accounts for almost all of the skin tumor-relate...
Blue light-driven cell cycle arrest in thyroid cancer via Retinal-OPN3 complex
Blue light-driven cell cycle arrest in thyroid cancer via Retinal-OPN3 complex
Papillary thyroid carcinoma (PTC) is the most common type of thyroid malignancy, with a rising incidence. Traditional trea...
Septins as key players in spermatogenesis, fertilisation and pre-implantation embryogenic cytoplasmic dynamics
Septins as key players in spermatogenesis, fertilisation and pre-implantation embryogenic cytoplasmic dynamics
Septins are a family of cytokinesis-related proteins involved in regulating cytoskeletal design, cell morphology, and tiss...
Transcriptional responses to direct and indirect TGFB1 stimulation in cancerous and noncancerous mammary epithelial cells
Transcriptional responses to direct and indirect TGFB1 stimulation in cancerous and noncancerous mammary epithelial cells
Transforming growth factor beta (TGFβ) is important for the morphogenesis and secretory function of the mammary gland...
Trogocytosis in CAR immune cell therapy: a key mechanism of tumor immune escape
Trogocytosis in CAR immune cell therapy: a key mechanism of tumor immune escape
Immune cell therapy based on chimeric antigen receptor (CAR) technology platform has been greatly developed. The types of ...
Potential probiotic Lactiplantibacillus plantarum strains alleviate TNF-α by regulating ADAM17 protein and ameliorate gut integrity through tight junction protein expression in in vitro model
Potential probiotic Lactiplantibacillus plantarum strains alleviate TNF-α by regulating ADAM17 protein and ameliorate gut integrity through tight junction protein expression in in vitro model
Lactiplantibacillus species are extensively studied for their ability to regulate host immune responses and functional the...
Gelsolin regulates intestinal stem cell regeneration and Th17 cellular function
Gelsolin regulates intestinal stem cell regeneration and Th17 cellular function
Intestinal stem cells (ISCs) are responsible for intestinal homeostasis and are important for the regeneration of damaged ...
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