SCI时时刷

search
+
miR-29a-3p orchestrates key signaling pathways for enhanced migration of human mesenchymal stem cells
miR-29a-3p orchestrates key signaling pathways for enhanced migration of human mesenchymal stem cells
The homing of human mesenchymal stem cells (hMSCs) is crucial for their therapeutic efficacy and is characterized by the o...
Targeting CCL2-CCR2 signaling pathway alleviates macrophage dysfunction in COPD via PI3K-AKT axis
Targeting CCL2-CCR2 signaling pathway alleviates macrophage dysfunction in COPD via PI3K-AKT axis
Chronic obstructive pulmonary disease (COPD) remains a leading cause of morbidity and mortality worldwide, characterized b...
IRF1 regulation of ZBP1 links mitochondrial DNA and chondrocyte damage in osteoarthritis
IRF1 regulation of ZBP1 links mitochondrial DNA and chondrocyte damage in osteoarthritis
Z-DNA binding protein 1 (ZBP1) is a nucleic acid sensor that is involved in multiple inflammatory diseases, but whether an...
Targeting TANK-binding kinase 1 attenuates painful diabetic neuropathy via inhibiting microglia pyroptosis
Targeting TANK-binding kinase 1 attenuates painful diabetic neuropathy via inhibiting microglia pyroptosis
Painful diabetic neuropathy (PDN) is closely linked to inflammation, which has been demonstrated to be associated with pyr...
17β-estradiol in colorectal cancer: friend or foe?
17β-estradiol in colorectal cancer: friend or foe?
Colorectal cancer (CRC) is a common gastrointestinal malignancy with higher incidence and mortality rates in men compared ...
Endometrial senescence is mediated by interleukin 17 receptor B signaling
Endometrial senescence is mediated by interleukin 17 receptor B signaling
We previously identified Il17RB, a member of the IL17 superfamily, as a candidate marker gene for endometrial aging. While...
Dihydroorotase MoPyr4 is required for development, pathogenicity, and autophagy in rice blast fungus
Dihydroorotase MoPyr4 is required for development, pathogenicity, and autophagy in rice blast fungus
Dihydroorotase (DHOase) is the third enzyme in the six enzymatic reaction steps of the endogenous pyrimidine nucleotide de...
The RNA binding protein IGF2BP2/IMP2 alters the cargo of cancer cell-derived extracellular vesicles supporting tumor-associated macrophages
The RNA binding protein IGF2BP2/IMP2 alters the cargo of cancer cell-derived extracellular vesicles supporting tumor-associated macrophages
Tumor cells release extracellular vesicles (EVs) that contribute to the polarization of macrophages towards tumor-associat...
Identification of the central role of RNA polymerase mitochondrial for angiogenesis
Identification of the central role of RNA polymerase mitochondrial for angiogenesis
Mitochondria are central to endothelial cell activation and angiogenesis, with the RNA polymerase mitochondrial (POLRMT) s...
Extracellular vesicles released by host epithelial cells during Pseudomonas aeruginosa infection function as homing beacons for neutrophils
Extracellular vesicles released by host epithelial cells during Pseudomonas aeruginosa infection function as homing beacons for neutrophils
Pseudomonas aeruginosa (PA) is an opportunistic pathogen that can cause sight threatening infections in the eye and fatal ...
Short-term response of primary human meniscus cells to simulated microgravity
Short-term response of primary human meniscus cells to simulated microgravity
Mechanical unloading of the knee articular cartilage results in cartilage matrix atrophy, signifying the osteoarthritic-in...
Mechanisms underlying neutrophils adhesion to triple-negative breast cancer cells via CD11b-ICAM1 in promoting breast cancer progression
Mechanisms underlying neutrophils adhesion to triple-negative breast cancer cells via CD11b-ICAM1 in promoting breast cancer progression
Triple-negative breast cancer (TNBC) is recognized as the most aggressive and immunologically infiltrated subtype of breas...
A novel approach to alleviate acetaminophen-induced hepatotoxicity with hybrid balloon flower root-derived exosome-like nanoparticles (BDEs) with silymarin via inhibition of hepatocyte MAPK pathway and apoptosis
A novel approach to alleviate acetaminophen-induced hepatotoxicity with hybrid balloon flower root-derived exosome-like nanoparticles (BDEs) with silymarin via inhibition of hepatocyte MAPK pathway and apoptosis
Balloon flower root-derived exosome-like nanoparticles (BDEs) have recently been proposed as physiologically active molecu...
Reciprocal regulation between RACGAP1 and AR contributes to endocrine therapy resistance in prostate cancer
Reciprocal regulation between RACGAP1 and AR contributes to endocrine therapy resistance in prostate cancer
Endocrine resistance driven by sustained activation of androgen receptor (AR) signaling pathway in advanced prostate cance...
The role of KLRG1: a novel biomarker and new therapeutic target
The role of KLRG1: a novel biomarker and new therapeutic target
Killer cell lectin-like receptor G1 (KLRG1) is an immune checkpoint receptor expressed predominantly in NK and T-cell subs...
Mechanisms, combination therapy, and biomarkers in cancer immunotherapy resistance
Mechanisms, combination therapy, and biomarkers in cancer immunotherapy resistance
Anti-programmed death 1/programmed death ligand 1 (anti-PD-1/PD-L1) antibodies exert significant antitumor effects by over...
SHH induces macrophage oxidative phosphorylation and efferocytosis to promote scar formation
SHH induces macrophage oxidative phosphorylation and efferocytosis to promote scar formation
Excessive scar formation such as hypertrophic scars and keloids, resulting from trauma or surgical procedures, present a w...
Biomechanics of circulating cellular and subcellular bioparticles: beyond separation
Biomechanics of circulating cellular and subcellular bioparticles: beyond separation
Biomechanical attributes have emerged as novel markers, providing a reliable means to characterize cellular and subcellula...
Correction: Activation of AMPK inhibits cervical cancer growth by hyperacetylation of H3K9 through PCAF
Correction: Activation of AMPK inhibits cervical cancer growth by hyperacetylation of H3K9 through PCAF
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Inhibition of WNT/β-catenin signalling during sex-specific gonadal differentiation is essential for normal human fetal testis development
Inhibition of WNT/β-catenin signalling during sex-specific gonadal differentiation is essential for normal human fetal testis development
Sex-specific gonadal differentiation is directed by complex signalling promoting development in either male or female dire...
KRAS-mutant non-small cell lung cancer (NSCLC) therapy based on tepotinib and omeprazole combination
KRAS-mutant non-small cell lung cancer (NSCLC) therapy based on tepotinib and omeprazole combination
KRAS-mutant non-small cell lung cancer (NSCLC) shows a relatively low response rate to chemotherapy, immunotherapy and KRA...
Podoplanin depletion in tonsil-derived mesenchymal stem cells induces cellular senescence via regulation of the p16Ink4a/Rb pathway
Podoplanin depletion in tonsil-derived mesenchymal stem cells induces cellular senescence via regulation of the p16Ink4a/Rb pathway
Mesenchymal stem cells (MSCs) are widely used in the development of therapeutic tools in regenerative medicine. However, t...
BI-2865, a pan-KRAS inhibitor, reverses the P-glycoprotein induced multidrug resistance in vitro and in vivo
BI-2865, a pan-KRAS inhibitor, reverses the P-glycoprotein induced multidrug resistance in vitro and in vivo
Multidrug resistance (MDR) limits successful cancer chemotherapy. P-glycoprotein (P-gp), BCRP and MRP1 are the key trigger...
Circadian patterns of growth factor receptor-dependent signaling and implications for carcinogenesis
Circadian patterns of growth factor receptor-dependent signaling and implications for carcinogenesis
Several different signaling pathways that regulate cell proliferation and differentiation are initiated by binding of liga...
The IL-33-ST2 axis plays a vital role in endometriosis via promoting epithelial–mesenchymal transition by phosphorylating β-catenin
The IL-33-ST2 axis plays a vital role in endometriosis via promoting epithelial–mesenchymal transition by phosphorylating β-catenin
Interleukin 33 (IL-33) is a crucial inflammatory factor that functions as an alarm signal in endometriosis (EMs). Epitheli...
Downregulation of the metalloproteinases ADAM10 or ADAM17 promotes osteoclast differentiation
Downregulation of the metalloproteinases ADAM10 or ADAM17 promotes osteoclast differentiation
Bone resorption is driven through osteoclast differentiation by macrophage colony-stimulating factor (M-CSF) and receptor ...
Targeting mTOR signaling pathways in multiple myeloma: biology and implication for therapy
Targeting mTOR signaling pathways in multiple myeloma: biology and implication for therapy
Multiple Myeloma (MM), a cancer of terminally differentiated plasma cells, is the second most prevalent hematological mali...
Motor skill learning modulates striatal extracellular vesicles’ content in a mouse model of Huntington’s disease
Motor skill learning modulates striatal extracellular vesicles’ content in a mouse model of Huntington’s disease
Huntington’s disease (HD) is a neurological disorder caused by a CAG expansion in the Huntingtin gene (HTT). HD path...
Altered glia-neuron communication in Alzheimer’s Disease affects WNT, p53, and NFkB Signaling determined by snRNA-seq
Altered glia-neuron communication in Alzheimer’s Disease affects WNT, p53, and NFkB Signaling determined by snRNA-seq
Alzheimer’s disease is the most common cause of dementia and is characterized by amyloid-β plaques, tau neurofi...
Homotherapy for heteropathy: therapeutic effect of Butein in NLRP3-driven diseases
Homotherapy for heteropathy: therapeutic effect of Butein in NLRP3-driven diseases
Aberrant inflammatory responses drive the initiation and progression of various diseases, and hyperactivation of NLRP3 inf...
阅读更多
format_indent_increase