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Her2 promotes early dissemination of breast cancer by inhibiting the p38 pathway through the downregulation of MAP3K4
Her2 promotes early dissemination of breast cancer by inhibiting the p38 pathway through the downregulation of MAP3K4
Early dissemination refers to the process by which cancer cells spread to distant organs at an early stage of the disease,...
HDAC10 switches NLRP3 modification from acetylation to ubiquitination and attenuates acute inflammatory diseases
HDAC10 switches NLRP3 modification from acetylation to ubiquitination and attenuates acute inflammatory diseases
The NOD-like receptor protein (NLRP)3 inflammasome is at the signaling hub center to instigate inflammation in response to...
Eplerenone, a mineralocorticoid receptor inhibitor, reduces cirrhosis associated changes of hepatocyte glucose and lipid metabolism
Eplerenone, a mineralocorticoid receptor inhibitor, reduces cirrhosis associated changes of hepatocyte glucose and lipid metabolism
Recent studies suggest a contribution of intrahepatic mineralocorticoid receptor (MR) activation to the development of cir...
V-ATPase in cancer: mechanistic insights and therapeutic potentials
V-ATPase in cancer: mechanistic insights and therapeutic potentials
Vacuolar-type H+-ATPase (V-ATPase) is a crucial proton pump that plays an essential role in maintaining intracellular pH h...
Exosomal ANXA2 facilitates ovarian cancer peritoneal metastasis by activating peritoneal mesothelial cells through binding with TLR2
Exosomal ANXA2 facilitates ovarian cancer peritoneal metastasis by activating peritoneal mesothelial cells through binding with TLR2
Peritoneal dissemination of ovarian cancer (OvCa) can be largely attributed to the formation of a metastatic microenvironm...
Platelet-derived extracellular vesicles induced through different activation pathways drive melanoma progression by functional and transcriptional changes
Platelet-derived extracellular vesicles induced through different activation pathways drive melanoma progression by functional and transcriptional changes
Beyond their conventional roles in hemostasis and wound healing, platelets have been shown to facilitate hematogenous meta...
Inflammasomes: potential therapeutic targets in hematopoietic stem cell transplantation
Inflammasomes: potential therapeutic targets in hematopoietic stem cell transplantation
The realm of hematopoietic stem cell transplantation (HSCT) has witnessed remarkable advancements in elevating the cure an...
STING exerts antiviral innate immune response by activating pentose phosphate pathway
STING exerts antiviral innate immune response by activating pentose phosphate pathway
The innate immune system serves as the host’s first line of defense against invading pathogens. Stimulator of interf...
Adipose tissue protects against skin photodamage through CD151- and AdipoQ- EVs
Adipose tissue protects against skin photodamage through CD151- and AdipoQ- EVs
To clarify the protective effects of subcutaneous adipose tissue (SAT) against photodamage, we utilized nude mouse skin wi...
Deubiquitinase MYSM1 promotes doxorubicin-induced cardiotoxicity by mediating TRIM21-ferroptosis axis in cardiomyocytes
Deubiquitinase MYSM1 promotes doxorubicin-induced cardiotoxicity by mediating TRIM21-ferroptosis axis in cardiomyocytes
Anthracycline antitumor drug doxorubicin (DOX) induces severe cardiotoxicity. Deubiquitinating enzymes (DUBs) are crucial ...
Functional circuits of LYL1 controlled by supraphysiological androgen in prostate cancer cells to regulate cell senescence
Functional circuits of LYL1 controlled by supraphysiological androgen in prostate cancer cells to regulate cell senescence
Prostate cancer (PCa) is a public health problem mostly reported in developed countries. The androgen receptor (AR) regula...
Biological and pharmacological roles of pyroptosis in pulmonary inflammation and fibrosis: recent advances and future directions
Biological and pharmacological roles of pyroptosis in pulmonary inflammation and fibrosis: recent advances and future directions
Pyroptosis, an inflammatory regulated cell death (RCD) mechanism, is characterized by cellular swelling, membrane rupture,...
Machine learning-aided discovery of T790M-mutant EGFR inhibitor CDDO-Me effectively suppresses non-small cell lung cancer growth
Machine learning-aided discovery of T790M-mutant EGFR inhibitor CDDO-Me effectively suppresses non-small cell lung cancer growth
Epidermal growth factor receptor (EGFR) T790M mutation often occurs during long durational erlotinib treatment of non-smal...
The CCL5/CCR5/SHP2 axis sustains Stat1 phosphorylation and activates NF-κB signaling promoting M1 macrophage polarization and exacerbating chronic prostatic inflammation
The CCL5/CCR5/SHP2 axis sustains Stat1 phosphorylation and activates NF-κB signaling promoting M1 macrophage polarization and exacerbating chronic prostatic inflammation
Chronic prostatitis (CP) is a condition markered by persistent prostate inflammation, yet the specific cytokines driving i...
A fully human IgG1 antibody targeting connexin 32 extracellular domain blocks CMTX1 hemichannel dysfunction in an in vitro model
A fully human IgG1 antibody targeting connexin 32 extracellular domain blocks CMTX1 hemichannel dysfunction in an in vitro model
Connexins (Cxs) are fundamental in cell–cell communication, functioning as gap junction channels (GJCs) that facilit...
Extrajunctional CLDN10 cooperates with LAT1 and accelerates clear cell renal cell carcinoma progression
Extrajunctional CLDN10 cooperates with LAT1 and accelerates clear cell renal cell carcinoma progression
In addition to their adhesive properties, cell adhesion molecules such as claudins (CLDNs) exhibit signaling ability to or...
Targeting autophagy in HCC treatment: exploiting the CD147 internalization pathway
Targeting autophagy in HCC treatment: exploiting the CD147 internalization pathway
Chemotherapy resistance in liver cancer is a major clinical issue, with CD147 playing a vital role in this process. Howeve...
RNA-binding protein HuR inhibition induces multiple programmed cell death in breast and prostate cancer
RNA-binding protein HuR inhibition induces multiple programmed cell death in breast and prostate cancer
The RNA-binding protein Hu antigen R (HuR) plays a pivotal role in cancer progression, and previous studies have demonstra...
Complexin regulation of synaptic vesicle release: mechanisms in the central nervous system and specialized retinal ribbon synapses
Complexin regulation of synaptic vesicle release: mechanisms in the central nervous system and specialized retinal ribbon synapses
Synaptic ribbons, recognized for their pivotal role in conveying sensory signals in the visual pathway, are intricate asse...
Atg5-deficient mesenchymal stem cells protect against non-alcoholic fatty liver by accelerating hepatocyte growth factor secretion
Atg5-deficient mesenchymal stem cells protect against non-alcoholic fatty liver by accelerating hepatocyte growth factor secretion
Mesenchymal stem cells (MSCs) have shown promising therapeutic potential in treating liver diseases, such as non-alcoholic...
Cultivation and molecular characterization of viable Helicobacter pylori from the root canal of 170 deciduous teeth of children
Cultivation and molecular characterization of viable Helicobacter pylori from the root canal of 170 deciduous teeth of children
Helicobacter pylori is a persistent pathogen in the human stomach. However, the proposed transmission route via the oral c...
The Yin and Yang of hsa-miR-1244 expression levels during activation of the UPR control cell fate
The Yin and Yang of hsa-miR-1244 expression levels during activation of the UPR control cell fate
Regulation of endoplasmic reticulum (ER) homeostasis plays a critical role in maintaining cell survival. When ER stress oc...
The impact of epithelial-mesenchymal transition (EMT) induced by metabolic processes and intracellular signaling pathways on chemo-resistance, metastasis, and recurrence in solid tumors
The impact of epithelial-mesenchymal transition (EMT) induced by metabolic processes and intracellular signaling pathways on chemo-resistance, metastasis, and recurrence in solid tumors
The intricate cellular process, known as the epithelial-mesenchymal transition (EMT), significantly influences solid tumor...
Identification of critical residues at the C-terminal tip of ACKR4 regulating chemokine internalization and βarrestin involvement
Identification of critical residues at the C-terminal tip of ACKR4 regulating chemokine internalization and βarrestin involvement
Atypical chemokine receptors (ACKRs) play an important role in regulating the availability of chemokines and are responsib...
Dysregulation of protein degradation and alteration of secretome in α-synuclein-exposed astrocytes: implications for dopaminergic neuronal dysfunction
Dysregulation of protein degradation and alteration of secretome in α-synuclein-exposed astrocytes: implications for dopaminergic neuronal dysfunction
A key factor in the propagation of α-synuclein pathology is the compromised protein quality control system. Variation...
The role of circRNAs in resistance to doxorubicin
The role of circRNAs in resistance to doxorubicin
Doxorubicin is an anthracyline recognized as an antitumor antibiotic agent. It is widely used in the chemotherapeutic regi...
Linear ubiquitination mediates coronavirus NSP14-induced NF-κB activation
Linear ubiquitination mediates coronavirus NSP14-induced NF-κB activation
Human coronaviruses exhibit a spectrum of symptoms, ranging from mild seasonal colds to severe respiratory manifestations....
A novel process for transcellular hemoglobin transport from macrophages to cancer cells
A novel process for transcellular hemoglobin transport from macrophages to cancer cells
Hemoglobin (Hb) performs its physiological function within the erythrocyte. Extracellular Hb has prooxidative and proinfla...
Chondroprotective functions of neutrophil-derived extracellular vesicles by promoting the production of secreted frizzled-related protein 5 in cartilage
Chondroprotective functions of neutrophil-derived extracellular vesicles by promoting the production of secreted frizzled-related protein 5 in cartilage
Osteoarthritis (OA) is the most common degenerative joint disease characterized by cartilage degradation and various degre...
Pin1 promotes human CaV2.1 channel polyubiquitination by RNF138: pathophysiological implication for episodic ataxia type 2
Pin1 promotes human CaV2.1 channel polyubiquitination by RNF138: pathophysiological implication for episodic ataxia type 2
Loss-of-function mutations in the human gene encoding the neuron-specific Ca2+ channel CaV2.1 are linked to the neurologic...
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