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Catalase-deficient mice induce aging faster through lysosomal dysfunction
Catalase-deficient mice induce aging faster through lysosomal dysfunction
Lysosomes are a central hub for cellular metabolism and are involved in the regulation of cell homeostasis through the deg...
UBE2O ubiquitinates PTRF/CAVIN1 and inhibits the secretion of exosome-related PTRF/CAVIN1
UBE2O ubiquitinates PTRF/CAVIN1 and inhibits the secretion of exosome-related PTRF/CAVIN1
Exosomes are small vesicles released by cells, which have crucial functions in intercellular communication. Exosomes origi...
RRP9 promotes gemcitabine resistance in pancreatic cancer via activating AKT signaling pathway
RRP9 promotes gemcitabine resistance in pancreatic cancer via activating AKT signaling pathway
Pancreatic cancer (PC) is a highly lethal malignancy regarding digestive system, which is the fourth leading factor of can...
PI3K/AKT signaling allows for MAPK/ERK pathway independency mediating dedifferentiation-driven treatment resistance in melanoma
PI3K/AKT signaling allows for MAPK/ERK pathway independency mediating dedifferentiation-driven treatment resistance in melanoma
Current therapeutic management of advanced melanoma patients largely depends on their BRAF mutation status. However, the v...
Intracellular cholesterol transport inhibition Impairs autophagy flux by decreasing autophagosome–lysosome fusion
Intracellular cholesterol transport inhibition Impairs autophagy flux by decreasing autophagosome–lysosome fusion
Autophagy is an intracellular degradation process crucial for homeostasis. During autophagy, a double-membrane autophagoso...
Mupirocin blocks imiquimod-induced psoriasis-like skin lesion by inhibiting epidermal isoleucyl-tRNA synthetase
Mupirocin blocks imiquimod-induced psoriasis-like skin lesion by inhibiting epidermal isoleucyl-tRNA synthetase
The Isoleucyl-tRNA synthetase (IARS) catalyzes isoleucine to the corresponding tRNA, maintaining the accuracy of gene tran...
FGF12 is a novel component of the nucleolar NOLC1/TCOF1 ribosome biogenesis complex
FGF12 is a novel component of the nucleolar NOLC1/TCOF1 ribosome biogenesis complex
Among the FGF proteins, the least characterized superfamily is the group of fibroblast growth factor homologous factors (F...
How vascular smooth muscle cell phenotype switching contributes to vascular disease
How vascular smooth muscle cell phenotype switching contributes to vascular disease
Vascular smooth muscle cells (VSMCs) are the most abundant cell in vessels. Earlier experiments have found that VSMCs poss...
The ERα-NRF2 signalling axis promotes bicalutamide resistance in prostate cancer
The ERα-NRF2 signalling axis promotes bicalutamide resistance in prostate cancer
Bicalutamide is a nonsteroidal antiandrogen widely used as a first-line clinical treatment for advanced prostate cancer (P...
Single-cell and bulk RNA sequencing reveal ligands and receptors associated with worse overall survival in serous ovarian cancer
Single-cell and bulk RNA sequencing reveal ligands and receptors associated with worse overall survival in serous ovarian cancer
Serous ovarian carcinoma is the most frequent histological subgroup of ovarian cancer and the leading cause of death among...
Endoplasmic reticulum stress targeted therapy for breast cancer
Endoplasmic reticulum stress targeted therapy for breast cancer
Recurrence, metastasis, and drug resistance are still big challenges in breast cancer therapy. Internal and external stres...
Forthcoming complications in recovered COVID-19 patients with COPD and asthma; possible therapeutic opportunities
Forthcoming complications in recovered COVID-19 patients with COPD and asthma; possible therapeutic opportunities
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been growing swiftly worldwide. Patients w...
The emerging role of exosomes in radiotherapy
The emerging role of exosomes in radiotherapy
Presently, more than half of cancer patients receive radiotherapy to cure localized cancer, palliate symptoms, or control ...
DNMT3A R882H mutation drives daunorubicin resistance in acute myeloid leukemia via regulating NRF2/NQO1 pathway
DNMT3A R882H mutation drives daunorubicin resistance in acute myeloid leukemia via regulating NRF2/NQO1 pathway
DNA methyltransferase 3A (DNMT3A) often mutate on arginine 882 (DNMT3AR882) in acute myeloid leukemia (AML). AML patients ...
MICALL2 as a substrate of ubiquitinase TRIM21 regulates tumorigenesis of colorectal cancer
MICALL2 as a substrate of ubiquitinase TRIM21 regulates tumorigenesis of colorectal cancer
Molecule interacting with CasL-like protein 2 (MICALL2) is believed to regulate cytoskeleton dynamics, tight junction form...
Potential role of autophagy induced by FLT3-ITD and acid ceramidase in acute myeloid leukemia chemo-resistance: new insights
Potential role of autophagy induced by FLT3-ITD and acid ceramidase in acute myeloid leukemia chemo-resistance: new insights
Acute myeloid leukemia (AML) is a type of leukemia with a poor prognosis and survival characterized by abnormal cell proli...
Caveolin-1 accelerates hypoxia-induced endothelial dysfunction in high-altitude cerebral edema
Caveolin-1 accelerates hypoxia-induced endothelial dysfunction in high-altitude cerebral edema
High-altitude cerebral edema (HACE) is a serious and potentially fatal brain injury that is caused by acute hypobaric hypo...
Lrpap1 deficiency leads to myopia through TGF-β-induced apoptosis in zebrafish
Lrpap1 deficiency leads to myopia through TGF-β-induced apoptosis in zebrafish
Frameshift mutations in LRPAP1 are responsible for autosomal recessive high myopia in human beings but its underlying mech...
Interplay of the transcription factor MRTF-A and matrix stiffness controls mammary acinar structure and protrusion formation
Interplay of the transcription factor MRTF-A and matrix stiffness controls mammary acinar structure and protrusion formation
Ongoing differentiation processes characterize the mammary gland during sexual development and reproduction. In contrast, ...
PGE2 promotes macrophage recruitment and neovascularization in murine wet-type AMD models
PGE2 promotes macrophage recruitment and neovascularization in murine wet-type AMD models
Age-related macular degeneration (AMD), a progressive chronic disease of the central retina, is a leading cause of blindne...