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Exosomes derived from programmed cell death: mechanism and biological significance
Exosomes derived from programmed cell death: mechanism and biological significance
Exosomes are nanoscale extracellular vesicles present in bodily fluids that mediate intercellular communication by transfe...
Extracellular vesicles from UTX-knockout endothelial cells boost neural stem cell differentiation in spinal cord injury
Extracellular vesicles from UTX-knockout endothelial cells boost neural stem cell differentiation in spinal cord injury
Vascular endothelial cells are pivotal in the pathophysiological progression following spinal cord injury (SCI). The UTX (...
O-GlcNAc of STING mediates antiviral innate immunity
O-GlcNAc of STING mediates antiviral innate immunity
O-GlcNAcylation modification affects multiple physiological and pathophysiolocal functions of cells. Altered O-GlcNAcylati...
KIT mutations and expression: current knowledge and new insights for overcoming IM resistance in GIST
KIT mutations and expression: current knowledge and new insights for overcoming IM resistance in GIST
Gastrointestinal stromal tumor (GIST) is the most common sarcoma located in gastrointestinal tract and derived from the in...
E-cadherin variants associated with oral facial clefts trigger aberrant cell motility in a REG1A-dependent manner
E-cadherin variants associated with oral facial clefts trigger aberrant cell motility in a REG1A-dependent manner
Germline mutations of E-cadherin contribute to hereditary diffuse gastric cancer (HDGC) and congenital malformations, such...
Apoptosis dysfunction: unravelling the interplay between ZBP1 activation and viral invasion in innate immune responses
Apoptosis dysfunction: unravelling the interplay between ZBP1 activation and viral invasion in innate immune responses
Apoptosis plays a pivotal role in pathogen elimination and maintaining homeostasis. However, viruses have evolved strategi...
Phase separation-mediated biomolecular condensates and their relationship to tumor
Phase separation-mediated biomolecular condensates and their relationship to tumor
Phase separation is a cellular phenomenon where macromolecules aggregate or segregate, giving rise to biomolecular condens...
CD73 mitigates ZEB1 expression in papillary thyroid carcinoma
CD73 mitigates ZEB1 expression in papillary thyroid carcinoma
ZEB1, a core transcription factor involved in epithelial-mesenchymal transition (EMT), is associated with aggressive cance...
Regulation of NCOA4-mediated iron recycling ameliorates paraquat-induced lung injury by inhibiting ferroptosis
Regulation of NCOA4-mediated iron recycling ameliorates paraquat-induced lung injury by inhibiting ferroptosis
Paraquat (PQ) is an irreplaceable insecticide in many countries for the advantage of fast-acting and broad-spectrum. Howev...
Hypoxic glioblastoma-cell-derived extracellular vesicles impair cGAS-STING activity in macrophages
Hypoxic glioblastoma-cell-derived extracellular vesicles impair cGAS-STING activity in macrophages
Solid tumors such as glioblastoma (GBM) exhibit hypoxic zones that are associated with poor prognosis and immunosuppressio...
Crosstalk among podocytes, glomerular endothelial cells and mesangial cells in diabetic kidney disease: an updated review
Crosstalk among podocytes, glomerular endothelial cells and mesangial cells in diabetic kidney disease: an updated review
Diabetic kidney disease (DKD) is a long-term and serious complication of diabetes that affects millions of people worldwid...
A resource database for protein kinase substrate sequence-preference motifs based on large-scale mass spectrometry data
A resource database for protein kinase substrate sequence-preference motifs based on large-scale mass spectrometry data
Protein phosphorylation is one of the most prevalent posttranslational modifications involved in molecular control of cell...
Dopamine enhances recovery after traumatic brain injury through ubiquitylation and autophagic degradation of RIPK1
Dopamine enhances recovery after traumatic brain injury through ubiquitylation and autophagic degradation of RIPK1
Although the neurotransmitter dopamine (DA) plays a crucial pathophysiologic role after traumatic brain injury (TBI), its ...
Autophagy-modulating biomaterials: multifunctional weapons to promote tissue regeneration
Autophagy-modulating biomaterials: multifunctional weapons to promote tissue regeneration
Autophagy is a self-renewal mechanism that maintains homeostasis and can promote tissue regeneration by regulating inflamm...
Connexin32 gap junction channels deliver miR155-3p to mediate pyroptosis in renal ischemia-reperfusion injury
Connexin32 gap junction channels deliver miR155-3p to mediate pyroptosis in renal ischemia-reperfusion injury
To explore whether the gap junction (GJ) composed by connexin32(Cx32) mediated pyroptosis in renal ischemia-reperfusion(I/...
IDH2/R140Q mutation confers cytokine-independent proliferation of TF-1 cells by activating constitutive STAT3/5 phosphorylation
IDH2/R140Q mutation confers cytokine-independent proliferation of TF-1 cells by activating constitutive STAT3/5 phosphorylation
R140Q mutation in isocitrate dehydrogenase 2 (IDH2) promotes leukemogenesis. Targeting IDH2/R140Q yields encouraging thera...