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A promising frontier: targeting NETs for stroke treatment breakthroughs
A promising frontier: targeting NETs for stroke treatment breakthroughs
Stroke is a prevalent global acute cerebrovascular condition, with ischaemic stroke being the most frequently occurring ty...
Neem leaf glycoprotein binding to Dectin-1 receptors on dendritic cell induces type-1 immunity through CARD9 mediated intracellular signal to NFκB
Neem leaf glycoprotein binding to Dectin-1 receptors on dendritic cell induces type-1 immunity through CARD9 mediated intracellular signal to NFκB
A water-soluble ingredient of mature leaves of the tropical mahogany ‘Neem’ (Azadirachta indica), was identifi...
Interleukin-4 protects retinal ganglion cells and promotes axon regeneration
Interleukin-4 protects retinal ganglion cells and promotes axon regeneration
The preservation of retinal ganglion cells (RGCs) and the facilitation of axon regeneration are crucial considerations in ...
Structural determinants for activation of the Tau kinase CDK5 by the serotonin receptor 5-HT7R
Structural determinants for activation of the Tau kinase CDK5 by the serotonin receptor 5-HT7R
Multiple neurodegenerative diseases are induced by the formation and deposition of protein aggregates. In particular, the ...
GDF9His209GlnfsTer6/S428T and GDF9Q321X/S428T bi-allelic variants caused female subfertility with defective follicle enlargement
GDF9His209GlnfsTer6/S428T and GDF9Q321X/S428T bi-allelic variants caused female subfertility with defective follicle enlargement
Antral follicles consist of an oocyte cumulus complex surrounding by somatic cells, including mural granulosa cells as the...
High glucose-induced p66Shc mitochondrial translocation regulates autophagy initiation and autophagosome formation in syncytiotrophoblast and extravillous trophoblast
High glucose-induced p66Shc mitochondrial translocation regulates autophagy initiation and autophagosome formation in syncytiotrophoblast and extravillous trophoblast
p66Shc, as a redox enzyme, regulates reactive oxygen species (ROS) production in mitochondria and autophagy. However, the ...
Role of imbalanced gut microbiota in promoting CRC metastasis: from theory to clinical application
Role of imbalanced gut microbiota in promoting CRC metastasis: from theory to clinical application
Metastasis poses a major challenge in colorectal cancer (CRC) treatment and remains a primary cause of mortality among pat...
Exploring the role of Prx II in mitigating endoplasmic reticulum stress and mitochondrial dysfunction in neurodegeneration
Exploring the role of Prx II in mitigating endoplasmic reticulum stress and mitochondrial dysfunction in neurodegeneration
Neurodegenerative diseases are increasingly recognized for their association with oxidative stress, which leads to progres...
Potentials and future perspectives of multi-target drugs in cancer treatment: the next generation anti-cancer agents
Potentials and future perspectives of multi-target drugs in cancer treatment: the next generation anti-cancer agents
Cancer is a major public health problem worldwide with more than an estimated 19.3 million new cases in 2020. The occurren...
Increased levels of villus-derived exosomal miR-29a-3p in normal pregnancy than uRPL patients suppresses decidual NK cell production of interferon-γ and exerts a therapeutic effect in abortion-prone mice
Increased levels of villus-derived exosomal miR-29a-3p in normal pregnancy than uRPL patients suppresses decidual NK cell production of interferon-γ and exerts a therapeutic effect in abortion-prone mice
Recurrent pregnancy loss (RPL) patients have higher absolute numbers of decidual natural killer (dNK) cells with elevated ...
Wnt signaling regulates chemokine production and cell migration of circulating human monocytes
Wnt signaling regulates chemokine production and cell migration of circulating human monocytes
The β-catenin dependent canonical Wnt signaling pathway plays a crucial role in maintaining normal homeostasis. Howev...
CDK7 in breast cancer: mechanisms of action and therapeutic potential
CDK7 in breast cancer: mechanisms of action and therapeutic potential
Cyclin-dependent kinase 7 (CDK7) serves as a pivotal regulator in orchestrating cellular cycle dynamics and gene transcrip...
RUNX1-BMP2 promotes vasculogenic mimicry in laryngeal squamous cell carcinoma via activation of the PI3K-AKT signaling pathway
RUNX1-BMP2 promotes vasculogenic mimicry in laryngeal squamous cell carcinoma via activation of the PI3K-AKT signaling pathway
Laryngeal squamous cell carcinoma (LSCC) is one of the most common malignant tumors of the head and neck. Vasculogenic mim...
Atg5 deficiency in macrophages protects against kidney fibrosis via the CCR6-CCL20 axis
Atg5 deficiency in macrophages protects against kidney fibrosis via the CCR6-CCL20 axis
Autophagy is a lysosome-dependent degradation pathway that regulates macrophage activation, differentiation, and polarizat...
Csn5 inhibits autophagy by regulating the ubiquitination of Atg6 and Tor to mediate the pathogenicity of Magnaporthe oryzae
Csn5 inhibits autophagy by regulating the ubiquitination of Atg6 and Tor to mediate the pathogenicity of Magnaporthe oryzae
Csn5 is subunit 5 of the COP9 signalosome (CSN), but the mechanism by which it strictly controls the pathogenicity of path...
Proteomic studies of VEGFR2 in human placentas reveal protein associations with preeclampsia, diabetes, gravidity, and labor
Proteomic studies of VEGFR2 in human placentas reveal protein associations with preeclampsia, diabetes, gravidity, and labor
VEGFR2 (Vascular endothelial growth factor receptor 2) is a central regulator of placental angiogenesis. The study of the ...
VDR promotes pancreatic cancer progression in vivo by activating CCL20-mediated M2 polarization of tumor associated macrophage
VDR promotes pancreatic cancer progression in vivo by activating CCL20-mediated M2 polarization of tumor associated macrophage
Activation of VDR pathway was a promising anti-tumor therapy strategy. However, numerous clinical studies have demonstrate...
Endomucin selectively regulates vascular endothelial growth factor receptor-2 endocytosis through its interaction with AP2
Endomucin selectively regulates vascular endothelial growth factor receptor-2 endocytosis through its interaction with AP2
The endothelial glycocalyx, located at the luminal surface of the endothelium, plays an important role in the regulation o...
The protein composition of exosomes released by prostate cancer cells is distinctly regulated by androgen receptor-antagonists and -agonist to stimulate growth of target cells
The protein composition of exosomes released by prostate cancer cells is distinctly regulated by androgen receptor-antagonists and -agonist to stimulate growth of target cells
Prostate cancer (PCa) is a prevalent malignancy in men worldwide, ranking as the second leading cause of cancer-related de...
Inhibition of adenylyl cyclase by GTPase-deficient Gαi is mechanistically different from that mediated by receptor-activated Gαi
Inhibition of adenylyl cyclase by GTPase-deficient Gαi is mechanistically different from that mediated by receptor-activated Gαi
Signal transduction through G protein-coupled receptors (GPCRs) has been a major focus in cell biology for decades. Numero...
The protein phosphatase-2A subunit PR130 is involved in the formation of cytotoxic protein aggregates in pancreatic ductal adenocarcinoma cells
The protein phosphatase-2A subunit PR130 is involved in the formation of cytotoxic protein aggregates in pancreatic ductal adenocarcinoma cells
As a major source of cellular serine and threonine phosphatase activity, protein phosphatase-2A (PP2A) modulates signaling...
Gut microbiota-derived butyrate restores impaired regulatory T cells in patients with AChR myasthenia gravis via mTOR-mediated autophagy
Gut microbiota-derived butyrate restores impaired regulatory T cells in patients with AChR myasthenia gravis via mTOR-mediated autophagy
More than 80% of patients with myasthenia gravis (MG) are positive for anti-acetylcholine receptor (AChR) antibodies. Regu...
Repetitive transcranial magnetic stimulation ameliorates cognitive deficits in mice with radiation-induced brain injury by attenuating microglial pyroptosis and promoting neurogenesis via BDNF pathway
Repetitive transcranial magnetic stimulation ameliorates cognitive deficits in mice with radiation-induced brain injury by attenuating microglial pyroptosis and promoting neurogenesis via BDNF pathway
Radiation-induced brain injury (RIBI) is a common and severe complication during radiotherapy for head and neck tumor. Rep...
Tobacco smoke condensate-induced senescence in endothelial cells was ameliorated by colchicine treatment via suppression of NF-κB and MAPKs P38 and ERK pathways activation
Tobacco smoke condensate-induced senescence in endothelial cells was ameliorated by colchicine treatment via suppression of NF-κB and MAPKs P38 and ERK pathways activation
Smoking is the major cause of cardiovascular diseases and cancer. It induces oxidative stress, leading to DNA damage and c...
EP300-ZNF384 transactivates IL3RA to promote the progression of B-cell acute lymphoblastic leukemia
EP300-ZNF384 transactivates IL3RA to promote the progression of B-cell acute lymphoblastic leukemia
The EP300-ZNF384 fusion gene is an oncogenic driver in B-cell acute lymphoblastic leukemia (B-ALL). In the present study, ...
Super enhancer lncRNAs: a novel hallmark in cancer
Super enhancer lncRNAs: a novel hallmark in cancer
Super enhancers (SEs) consist of clusters of enhancers, harboring an unusually high density of transcription factors, medi...
The interaction of inflammasomes and gut microbiota: novel therapeutic insights
The interaction of inflammasomes and gut microbiota: novel therapeutic insights
Inflammasomes are complex platforms for the cleavage and release of inactivated IL-1β and IL-18 cytokines that trigge...
SUMOylation of annexin A6 retards cell migration and tumor growth by suppressing RHOU/AKT1–involved EMT in hepatocellular carcinoma
SUMOylation of annexin A6 retards cell migration and tumor growth by suppressing RHOU/AKT1–involved EMT in hepatocellular carcinoma
The protein annexin A6 (AnxA6) is involved in numerous membrane-related biological processes including cell migration and ...
JAK/STAT mediated insulin resistance in muscles is essential for effective immune response
JAK/STAT mediated insulin resistance in muscles is essential for effective immune response
The metabolically demanding nature of immune response requires nutrients to be preferentially directed towards the immune ...
Integrating transcriptomics, glycomics and glycoproteomics to characterize hepatitis B virus-associated hepatocellular carcinoma
Integrating transcriptomics, glycomics and glycoproteomics to characterize hepatitis B virus-associated hepatocellular carcinoma
Hepatocellular carcinoma (HCC) ranks as the third most common cause of cancer related death globally, representing a subst...
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