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Cellular crosstalk in atherosclerotic plaque microenvironment
Cellular crosstalk in atherosclerotic plaque microenvironment
Atherosclerosis is an underlying pathology of many vascular diseases as a result of cellular, structural and molecular dys...
Vitamin D receptor (VDR) on the cell membrane of mouse macrophages participates in the formation of lipopolysaccharide tolerance: mVDR is related to the effect of artesunate to reverse LPS tolerance
Vitamin D receptor (VDR) on the cell membrane of mouse macrophages participates in the formation of lipopolysaccharide tolerance: mVDR is related to the effect of artesunate to reverse LPS tolerance
It is unclear whether membrane vitamin D receptor (mVDR) exists on the macrophage membrane or whether mVDR is associated w...
Tricyclic antidepressants induce liver inflammation by targeting NLRP3 inflammasome activation
Tricyclic antidepressants induce liver inflammation by targeting NLRP3 inflammasome activation
Idiosyncratic drug-induced liver injury (IDILI) is common in hepatology practices and, in some cases, lethal. Increasing e...
METTL3 and STAT3 form a positive feedback loop to promote cell metastasis in hepatocellular carcinoma
METTL3 and STAT3 form a positive feedback loop to promote cell metastasis in hepatocellular carcinoma
It is well-established that most Hepatocellular carcinoma (HCC) patients die of metastasis, yet the potential mechanisms o...
Short report galectins use N-glycans of FGFs to capture growth factors at the cell surface and fine-tune their signaling
Short report galectins use N-glycans of FGFs to capture growth factors at the cell surface and fine-tune their signaling
Fibroblast growth factors (FGFs) and their receptors (FGFRs) constitute complex signaling hubs that are crucial for the de...
Radiation combined with immune checkpoint inhibitors for unresectable locally advanced non-small cell lung cancer: synergistic mechanisms, current state, challenges, and orientations
Radiation combined with immune checkpoint inhibitors for unresectable locally advanced non-small cell lung cancer: synergistic mechanisms, current state, challenges, and orientations
Until the advent of immune checkpoint inhibitors (ICIs), definitive radiotherapy (RT) concurrently with chemotherapy was r...
Autophagy modulators influence the content of important signalling molecules in PS-positive extracellular vesicles
Autophagy modulators influence the content of important signalling molecules in PS-positive extracellular vesicles
Extracellular vesicles (EVs) are important mediators of intercellular communication in the tumour microenvironment. Many s...
Physiological and pathological consequences of exosomes at the blood–brain-barrier interface
Physiological and pathological consequences of exosomes at the blood–brain-barrier interface
Blood–brain barrier (BBB) interface with multicellular structure controls strictly the entry of varied circulating m...
Small extracellular vesicle-mediated metabolic reprogramming: from tumors to pre-metastatic niche formation
Small extracellular vesicle-mediated metabolic reprogramming: from tumors to pre-metastatic niche formation
Metastasis, the spread of a tumor or cancer from the primary site of the body to a secondary site, is a multi-step process...
Synergistic immunotherapy targeting cancer-associated anemia: prospects of a combination strategy
Synergistic immunotherapy targeting cancer-associated anemia: prospects of a combination strategy
Cancer-associated anemia promotes tumor progression, leads to poor quality of life in patients with cancer, and even obstr...
Pyroptosis, ferroptosis, and autophagy cross-talk in glioblastoma opens up new avenues for glioblastoma treatment
Pyroptosis, ferroptosis, and autophagy cross-talk in glioblastoma opens up new avenues for glioblastoma treatment
Glioma is a common primary tumor of the central nervous system (CNS), with glioblastoma multiforme (GBM) being the most ma...
Zika virus triggers autophagy to exploit host lipid metabolism and drive viral replication
Zika virus triggers autophagy to exploit host lipid metabolism and drive viral replication
Zika virus (ZIKV), an arbovirus of global concern, has been associated with neurological complications including microceph...
Single-cell RNA sequencing reveals the vascular smooth muscle cell phenotypic landscape in aortic aneurysm
Single-cell RNA sequencing reveals the vascular smooth muscle cell phenotypic landscape in aortic aneurysm
Phenotypic switching in vascular smooth muscle cells (VSMCs) has been linked to aortic aneurysm, but the phenotypic landsc...
Bacterial extracellular vesicles repress the vascular protective factor RNase1 in human lung endothelial cells
Bacterial extracellular vesicles repress the vascular protective factor RNase1 in human lung endothelial cells
Sepsis is one of the leading causes of death worldwide and characterized by blood stream infections associated with a dysr...
Bacillus cereus extracellular vesicles act as shuttles for biologically active multicomponent enterotoxins
Bacillus cereus extracellular vesicles act as shuttles for biologically active multicomponent enterotoxins
Extracellular vesicles (EVs) from Gram-positive bacteria have gained considerable importance as a novel transport system o...
Structural and non-structural proteins in SARS-CoV-2: potential aspects to COVID-19 treatment or prevention of progression of related diseases
Structural and non-structural proteins in SARS-CoV-2: potential aspects to COVID-19 treatment or prevention of progression of related diseases
Coronavirus disease 2019 (COVID-19) is caused by a new member of the Coronaviridae family known as severe acute respirator...
KRAS, MYC, and ARF6: inseparable relationships cooperatively promote cancer malignancy and immune evasion
KRAS, MYC, and ARF6: inseparable relationships cooperatively promote cancer malignancy and immune evasion
Mutations in the KRAS gene and overexpression of protein products of the MYC and ARF6 genes occur frequently in cancer. He...
Spotlight on the impact of viral infections on Hematopoietic Stem Cells (HSCs) with a focus on COVID-19 effects
Spotlight on the impact of viral infections on Hematopoietic Stem Cells (HSCs) with a focus on COVID-19 effects
Hematopoietic stem cells (HSCs) are known for their significant capability to reconstitute and preserve a functional hemat...
25KDa branched polyethylenimine increases interferon-γ production in natural killer cells via improving translation efficiency
25KDa branched polyethylenimine increases interferon-γ production in natural killer cells via improving translation efficiency
Ex vivo cultivation is a promising strategy for increasing the number of NK cells and enhancing their antitumor activity p...
Crosstalk between macrophages and cardiac cells after myocardial infarction
Crosstalk between macrophages and cardiac cells after myocardial infarction
Cardiovascular diseases, such as myocardial infarction (MI), are a leading cause of death worldwide. Acute MI (AMI) inflic...
Cancer-associated fibroblasts in radiotherapy: Bystanders or protagonists?
Cancer-associated fibroblasts in radiotherapy: Bystanders or protagonists?
The primary goal of radiotherapy (RT) is to induce cellular damage on malignant cells; however, it is becoming increasingl...
What is new in cancer-associated fibroblast biomarkers?
What is new in cancer-associated fibroblast biomarkers?
The tumor microenvironment is one of the important drivers of tumor development. Cancer-associated fibroblasts (CAFs) are ...
The Warburg effect modulates DHODH role in ferroptosis: a review
The Warburg effect modulates DHODH role in ferroptosis: a review
Ferroptosis is an iron-dependent regulated cell death that suppresses tumor growth. It is activated by extensive peroxidat...
Change in cytokine profiles released by mast cells mediated by lung cancer-derived exosome activation may contribute to cancer-associated coagulation disorders
Change in cytokine profiles released by mast cells mediated by lung cancer-derived exosome activation may contribute to cancer-associated coagulation disorders
Coagulation disorders are a significant cause of lung cancer mortality. Although mast cells are known to play a role in co...
Small heterodimer partner interacting leucine zipper protein (SMILE) ameliorates autoimmune arthritis via AMPK signaling pathway and the regulation of B cell activation
Small heterodimer partner interacting leucine zipper protein (SMILE) ameliorates autoimmune arthritis via AMPK signaling pathway and the regulation of B cell activation
Rheumatoid arthritis (RA) is an autoimmune disease that causes joint swelling and inflammation and can involve the entire ...
CircRNAs: versatile players and new targets in organ fibrosis
CircRNAs: versatile players and new targets in organ fibrosis
Organ fibrosis can occur in virtually all major organs with relentlessly progressive and irreversible progress, ultimately...
Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy
Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy
Cancer is a leading cause of death worldwide and involves an oxidative stress mechanism. The transcription factor Nrf2 has...
Amino acid metabolism regulated by lncRNAs: the propellant behind cancer metabolic reprogramming
Amino acid metabolism regulated by lncRNAs: the propellant behind cancer metabolic reprogramming
Metabolic reprogramming is one of the main characteristics of cancer cells and plays pivotal role in the proliferation and...
Recent advances in the roles of exosomal microRNAs (exomiRs) in hematologic neoplasms: pathogenesis, diagnosis, and treatment
Recent advances in the roles of exosomal microRNAs (exomiRs) in hematologic neoplasms: pathogenesis, diagnosis, and treatment
In clinical diagnosis, the capability of exosomes to serve as biomarkers is one of the most important biological functions...
Neutrophil extracellular traps induced by the hypoxic microenvironment in gastric cancer augment tumour growth
Neutrophil extracellular traps induced by the hypoxic microenvironment in gastric cancer augment tumour growth
Inflammation-related predisposition to cancer plays an essential role in cancer progression and is associated with poor pr...
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