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NKX6.3 modulation of mitotic dynamics and genomic stability in gastric carcinogenesis
NKX6.3 modulation of mitotic dynamics and genomic stability in gastric carcinogenesis
Gastric cancer remains a significant global health challenge, characterized by poor prognosis and high mortality rates. Mi...
Full-length and N-terminally truncated recombinant interleukin-38 variants are similarly inefficient in antagonizing interleukin-36 and interleukin-1 receptors
Full-length and N-terminally truncated recombinant interleukin-38 variants are similarly inefficient in antagonizing interleukin-36 and interleukin-1 receptors
Interleukin (IL)-38 is an IL-1 family cytokine that was proposed to exert anti-inflammatory effects. However, its mechanis...
Correction: Staphylococcus aureus vesicles impair cutaneous wound healing through p38 MAPK-MerTK cleavage-mediated inhibition of macrophage efferocytosis
Correction: Staphylococcus aureus vesicles impair cutaneous wound healing through p38 MAPK-MerTK cleavage-mediated inhibition of macrophage efferocytosis
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4....
Role of cardiolipin in skeletal muscle function and its therapeutic implications
Role of cardiolipin in skeletal muscle function and its therapeutic implications
Cardiolipin, a unique phospholipid predominantly present in the inner mitochondrial membrane, is critical for maintaining ...
Dual regulation of the levels and function of Start transcriptional repressors drives G1 arrest in response to cell wall stress
Dual regulation of the levels and function of Start transcriptional repressors drives G1 arrest in response to cell wall stress
Many different stress signaling pathways converge in a common response: slowdown or arrest cell cycle in the G1 phase. The...
The role of circadian rhythm regulator PERs in oxidative stress, immunity, and cancer development
The role of circadian rhythm regulator PERs in oxidative stress, immunity, and cancer development
The complex interaction between circadian rhythms and physiological functions is essential for maintaining human health. A...
Phosphorylation of Bok at Ser-8 blocks its ability to suppress IP3R-mediated calcium mobilization
Phosphorylation of Bok at Ser-8 blocks its ability to suppress IP3R-mediated calcium mobilization
Bok is a poorly characterized Bcl-2 protein family member with roles yet to be clearly defined. It is clear, however, that...
Signal integrator function of CXXC5 in Cancer
Signal integrator function of CXXC5 in Cancer
CXXC type zinc finger protein 5 (CXXC5) is a member of the ZF-CXXC family and plays a pivotal role in signal integration a...
PD-L1 positive platelets mediate resistance to immune checkpoint inhibitors in patients with colorectal cancer
PD-L1 positive platelets mediate resistance to immune checkpoint inhibitors in patients with colorectal cancer
Programmed cell death ligand 1 (PD-L1) expression on immune cells is correlated with the efficacy of immune checkpoint inh...
The endonuclease activity of MCPIP1 controls the neoplastic transformation of epithelial cells via the c-Met/CD44 axis
The endonuclease activity of MCPIP1 controls the neoplastic transformation of epithelial cells via the c-Met/CD44 axis
The RNase activity of MCPIP1 is essential for regulating cellular homeostasis, proliferation, and tumorigenesis. Our study...
Histone demethylases in autophagy and inflammation
Histone demethylases in autophagy and inflammation
Autophagy dysfunction is associated with changes in autophagy-related genes. Various factors are connected to autophagy, a...
Targeting the ERK1/2 and p38 MAPK pathways attenuates Golgi tethering factor golgin-97 depletion-induced cancer progression in breast cancer
Targeting the ERK1/2 and p38 MAPK pathways attenuates Golgi tethering factor golgin-97 depletion-induced cancer progression in breast cancer
The Golgi apparatus is widely considered a secretory center and a hub for different signaling pathways. Abnormalities in G...
Integrative analysis of Ewing’s sarcoma reveals that the MIF-CD74 axis is a target for immunotherapy
Integrative analysis of Ewing’s sarcoma reveals that the MIF-CD74 axis is a target for immunotherapy
Ewing’s sarcoma (EwS), a common pediatric bone cancer, is associated with poor survival due to a lack of therapeutic...
Klebsiella pneumoniae-derived extracellular vesicles impair endothelial function by inhibiting SIRT1
Klebsiella pneumoniae-derived extracellular vesicles impair endothelial function by inhibiting SIRT1
The potential role of Klebsiella pneumoniae (K.pn) in hypertension development has been emphasized, although the specific ...
In vitro effect of hCG on cryptorchid patients’ gubernacular cells: a predictive model for adjuvant personalized therapy
In vitro effect of hCG on cryptorchid patients’ gubernacular cells: a predictive model for adjuvant personalized therapy
Cryptorchidism is the absence of one or both testicles in the scrotum at birth, being a risk factor for testis cancer and ...
Co-targeting of glial activation and inflammation by tsRNA-Gln-i-0095 for treating retinal ischemic pathologies
Co-targeting of glial activation and inflammation by tsRNA-Gln-i-0095 for treating retinal ischemic pathologies
Ischemic retinopathies are the major causes of blindness, yet effective early-stage treatments remain limited due to an in...
Role of sirtuins in obesity and osteoporosis: molecular mechanisms and therapeutic targets
Role of sirtuins in obesity and osteoporosis: molecular mechanisms and therapeutic targets
The prevalence of obesity and osteoporosis (OP) represents a significant public health concern on a global scale. A substa...
Regulation of calcium homeostasis in endoplasmic reticulum–mitochondria crosstalk: implications for skeletal muscle atrophy
Regulation of calcium homeostasis in endoplasmic reticulum–mitochondria crosstalk: implications for skeletal muscle atrophy
This review comprehensively explores the critical role of calcium as an essential small-molecule biomessenger in skeletal ...
PRDX5 and PRDX6 translocation and oligomerization in bull sperm: a response to cryopreservation-induced oxidative stress
PRDX5 and PRDX6 translocation and oligomerization in bull sperm: a response to cryopreservation-induced oxidative stress
Cryopreservation of bull sperm, crucial for breeding and assisted reproduction, often reduces sperm quality due to oxidati...
Broadening horizons: molecular mechanisms and disease implications of endothelial-to-mesenchymal transition
Broadening horizons: molecular mechanisms and disease implications of endothelial-to-mesenchymal transition
Endothelial-mesenchymal transition (EndMT) is defined as an important process of cellular differentiation by which endothe...
Staphylococcus aureus vesicles impair cutaneous wound healing through p38 MAPK-MerTK cleavage-mediated inhibition of macrophage efferocytosis
Staphylococcus aureus vesicles impair cutaneous wound healing through p38 MAPK-MerTK cleavage-mediated inhibition of macrophage efferocytosis
Staphylococcus aureus, a known contributor to non-healing wounds, releases vesicles (SAVs) that influence the delicate bal...
FOXC1-mediated serine metabolism reprogramming enhances colorectal cancer growth and 5-FU resistance under serine restriction
FOXC1-mediated serine metabolism reprogramming enhances colorectal cancer growth and 5-FU resistance under serine restriction
Colorectal cancer (CRC) is the most common gastrointestinal malignancy, and 5-Fluorouracil (5-FU) is the principal chemoth...
Nanoscopy reveals integrin clustering reliant on kindlin-3 but not talin-1
Nanoscopy reveals integrin clustering reliant on kindlin-3 but not talin-1
1. Kindlin-3 but not talin-1 contributes to integrin inside-out signaling induced β2 integrin clustering. 2. The Plec...
N88S seipin-related seipinopathy is a lipidopathy associated with loss of iron homeostasis
N88S seipin-related seipinopathy is a lipidopathy associated with loss of iron homeostasis
Seipin is a protein encoded by the BSCL2 gene in humans and SEI1 gene in yeast, forming an Endoplasmic Reticulum (ER)-boun...
Autophagy mediated by ROS-AKT-FoxO pathway is required for intestinal regeneration in echinoderms
Autophagy mediated by ROS-AKT-FoxO pathway is required for intestinal regeneration in echinoderms
Autophagy is essential for maintaining material balance and energy circulation and plays a critical role as a regulatory m...
BMAL1 ameliorates type 2 diabetes-induced cognitive impairment via AREG upregulation and PI3K/Akt/GSK-3β pathway activation
BMAL1 ameliorates type 2 diabetes-induced cognitive impairment via AREG upregulation and PI3K/Akt/GSK-3β pathway activation
Cognitive impairment is a significant complication of type 2 diabetes mellitus (T2DM). However, the mechanisms underlying ...
The role of tribbles homolog 2 in cell proliferation
The role of tribbles homolog 2 in cell proliferation
Tribbles homolog 2 (TRIB2), a pseudoserine/threonine kinase, is a member of the TRIB family. TRIB2 primarily regulates cel...
Helicobacter pylori infection promotes M1 macrophage polarization and gastric inflammation by activation of NLRP3 inflammasome via TNF/TNFR1 axis
Helicobacter pylori infection promotes M1 macrophage polarization and gastric inflammation by activation of NLRP3 inflammasome via TNF/TNFR1 axis
Macrophages play a crucial role in chronic gastritis induced by the pathogenic Helicobacter pylori (H. pylori) infection. ...
Loss of LRRK2 activity induces cytoskeleton defects and oxidative stress during porcine oocyte maturation
Loss of LRRK2 activity induces cytoskeleton defects and oxidative stress during porcine oocyte maturation
Leucine-rich repeat kinase 2 (LRRK2) is a ROCO family member which its mutation is closely related with Parkinson’s ...
Role of the Notch signaling pathway in porcine oocyte maturation
Role of the Notch signaling pathway in porcine oocyte maturation
Although the Notch signaling pathway is known to play an important role in ovarian follicle development in mammals, whethe...
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