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Early systemic insults following severe sepsis-associated encephalopathy of critically ill patients: association with mortality and awakening—an analysis of the OUTCOMEREA database
Early systemic insults following severe sepsis-associated encephalopathy of critically ill patients: association with mortality and awakening—an analysis of the OUTCOMEREA database
Sepsis-associated encephalopathy (SAE) may be worsened by early systemic insults. We aimed to investigate the association ...
Impact of hyper- and hypothermia on cellular and whole-body physiology
Impact of hyper- and hypothermia on cellular and whole-body physiology
The incidence of heat-related illnesses and heatstroke continues to rise amidst global warming. Hyperthermia triggers infl...
Age-dependent differences in the association between blood interleukin-6 levels and mortality in patients with sepsis: a retrospective observational study
Age-dependent differences in the association between blood interleukin-6 levels and mortality in patients with sepsis: a retrospective observational study
Interleukin-6 (IL-6) is a cytokine that predicts clinical outcomes in critically ill patients, including those with sepsis...
Intravenous branched-chain amino acid administration for the acute treatment of hepatic encephalopathy: a systematic review and meta-analysis
Intravenous branched-chain amino acid administration for the acute treatment of hepatic encephalopathy: a systematic review and meta-analysis
Hepatic encephalopathy (HE) is a severe complication of acute hepatic failure requiring urgent critical care management. B...
Sepsis-induced cardiogenic shock: controversies and evidence gaps in diagnosis and management
Sepsis-induced cardiogenic shock: controversies and evidence gaps in diagnosis and management
Sepsis often leads to vasoplegia and a hyperdynamic cardiac state, with treatment focused on restoring vascular tone. Howe...
Association of continuous renal replacement therapy downtime with fluid balance gap and clinical outcomes: a retrospective cohort analysis utilizing EHR and machine data
Association of continuous renal replacement therapy downtime with fluid balance gap and clinical outcomes: a retrospective cohort analysis utilizing EHR and machine data
Fluid balance gap (FBgap—prescribed vs. achieved) is associated with hospital mortality. Downtime is an important qu...
Long-term prevalence of PTSD symptom in family members of severe COVID-19 patients: a serial follow-up study extending to 18 months after ICU discharge
Long-term prevalence of PTSD symptom in family members of severe COVID-19 patients: a serial follow-up study extending to 18 months after ICU discharge
Experiencing a loved one's stay in the intensive care unit (ICU) can profoundly affect families, often leading to post...
Impact of board-certified intensive care training facilities on choice of adjunctive therapies and prognosis of severe respiratory failure: a nationwide cohort study
Impact of board-certified intensive care training facilities on choice of adjunctive therapies and prognosis of severe respiratory failure: a nationwide cohort study
Patients with severe respiratory failure have high mortality and need various interventions. However, the impact of intens...
Early predictors of unfavorable outcomes in pediatric acute respiratory failure
Early predictors of unfavorable outcomes in pediatric acute respiratory failure
Acute respiratory failure is a leading cause of critical illness in children. However, patient outcomes and early predicto...
Impact of inhaled nitric oxide therapy in patients with cardiogenic shock treated with veno-arterial extracorporeal membrane oxygenation combined with Impella: a retrospective cohort study
Impact of inhaled nitric oxide therapy in patients with cardiogenic shock treated with veno-arterial extracorporeal membrane oxygenation combined with Impella: a retrospective cohort study
The mortality rate of patients with cardiogenic shock (CS) requiring veno-arterial extracorporeal membrane oxygenation (VA...
Long-term health outcomes of COVID-19 in ICU- and non-ICU-treated patients up to 2 years after hospitalization: a longitudinal cohort study (CO-FLOW)
Long-term health outcomes of COVID-19 in ICU- and non-ICU-treated patients up to 2 years after hospitalization: a longitudinal cohort study (CO-FLOW)
Many patients hospitalized for COVID-19 experience long-term health problems, but comprehensive longitudinal data up to 2&...
Increased national critical care demands were associated with a higher mortality of intubated COVID-19 patients in Japan: a retrospective observational study
Increased national critical care demands were associated with a higher mortality of intubated COVID-19 patients in Japan: a retrospective observational study
There was no study to investigate the association between the national surge of Coronavirus disease 2019 (COVID-19) patien...
Clinical characteristics and short-term outcomes of patients with critical acute pulmonary embolism requiring extracorporeal membrane oxygenation: from the COMMAND VTE Registry-2
Clinical characteristics and short-term outcomes of patients with critical acute pulmonary embolism requiring extracorporeal membrane oxygenation: from the COMMAND VTE Registry-2
Extracorporeal membrane oxygenation (ECMO) might be required as a treatment option in patients with critical pulmonary emb...
Current status of bacteriophage therapy for severe bacterial infections
Current status of bacteriophage therapy for severe bacterial infections
The increase in the incidence of antibiotic-resistant bacteria poses a global public health threat. According to a 2019 WH...
Hemorrhages and risk factors in patients undergoing thromboprophylaxis in a respiratory critical care unit: a secondary data analysis of a cohort study
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Height status matters for risk of mortality in critically ill children
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Autophagy and autophagic cell death in sepsis: friend or foe?
Autophagy and autophagic cell death in sepsis: friend or foe?
In sepsis, inflammation, and nutrient deficiencies endanger cellular homeostasis and survival. Autophagy is primarily a me...
Three-month outcomes and cost-effectiveness of interferon gamma-1b in critically ill patients: a secondary analysis of the PREV-HAP trial
Three-month outcomes and cost-effectiveness of interferon gamma-1b in critically ill patients: a secondary analysis of the PREV-HAP trial
Interferon gamma‑1b has been proposed to treat critical illness-induced immunosuppression. We aimed to determine the...
Effects of normal saline versus lactated Ringer’s solution on organ function and inflammatory responses to heatstroke in rats
Effects of normal saline versus lactated Ringer’s solution on organ function and inflammatory responses to heatstroke in rats
Heatstroke is a life-threatening condition characterized by severe hyperthermia and multiple organ dysfunction. Both norma...
Monte Carlo simulations of cefepime in children receiving continuous kidney replacement therapy support continuous infusions for target attainment
Monte Carlo simulations of cefepime in children receiving continuous kidney replacement therapy support continuous infusions for target attainment
Sepsis is a leading cause of acute kidney injury requiring continuous kidney replacement therapy (CKRT) and CKRT can alter...
Recovery of consciousness after acute brain injury: a narrative review
Recovery of consciousness after acute brain injury: a narrative review
Disorders of consciousness (DoC) are frequently encountered in both, acute and chronic brain injuries. In many countries, ...
Remifentanil vs. dexmedetomidine for cardiac surgery patients with noninvasive ventilation intolerance: a multicenter randomized controlled trial
Remifentanil vs. dexmedetomidine for cardiac surgery patients with noninvasive ventilation intolerance: a multicenter randomized controlled trial
The optimal sedative regime for noninvasive ventilation (NIV) intolerance remains uncertain. The present study aimed to as...
Association between red blood cell distribution width and 30-day mortality in critically ill septic patients: a propensity score-matched study
Association between red blood cell distribution width and 30-day mortality in critically ill septic patients: a propensity score-matched study
Sepsis is the leading cause of death worldwide, and a number of biomarkers have been developed for early mortality risk st...
Acute lung injury and post-cardiac arrest syndrome: a narrative review
Acute lung injury and post-cardiac arrest syndrome: a narrative review
Post-cardiac arrest syndrome (PCAS) presents a multifaceted challenge in clinical practice, characterized by severe neurol...
Which factors are associated with acquired weakness in the ICU? An overview of systematic reviews and meta-analyses
Which factors are associated with acquired weakness in the ICU? An overview of systematic reviews and meta-analyses
Intensive care unit-acquired weakness (ICUAW) is common in critically ill patients, characterized by muscle weakness and p...
Impact of sympathetic hyperactivity induced by brain microglial activation on organ damage in sepsis with chronic kidney disease
Impact of sympathetic hyperactivity induced by brain microglial activation on organ damage in sepsis with chronic kidney disease
Sympathetic nerve activity (SNA) plays a central role in the pathogenesis of several diseases such as sepsis and chronic k...
Impacts of three inspiratory muscle training programs on inspiratory muscles strength and endurance among intubated and mechanically ventilated patients with difficult weaning: a multicentre randomised controlled trial
Impacts of three inspiratory muscle training programs on inspiratory muscles strength and endurance among intubated and mechanically ventilated patients with difficult weaning: a multicentre randomised controlled trial
Inspiratory muscle training (IMT) is well-established as a safe option for combating inspiratory muscles weakness in the i...
Nutritional therapy for the prevention of post-intensive care syndrome
Nutritional therapy for the prevention of post-intensive care syndrome
Post-intensive care syndrome (PICS) is a triad of physical, cognitive, and mental impairments that occur during or followi...
Increasing plasma calprotectin (S100A8/A9) is associated with 12-month mortality and unfavourable functional outcome in critically ill COVID-19 patients
Increasing plasma calprotectin (S100A8/A9) is associated with 12-month mortality and unfavourable functional outcome in critically ill COVID-19 patients
Calprotectin (S100A8/A9) is a pro-inflammatory mediator primarily released from neutrophils. Previous studies have reveale...
Normal saline versus Ringer’s solution and critical-illness mortality in acute pancreatitis: a nationwide inpatient database study
Normal saline versus Ringer’s solution and critical-illness mortality in acute pancreatitis: a nationwide inpatient database study
Fluid resuscitation is fundamental in acute pancreatitis (AP) treatment. However, the optimal choice between normal saline...
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