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Three-month outcomes and cost-effectiveness of interferon gamma-1b in critically ill patients: a secondary analysis of the PREV-HAP trial
Three-month outcomes and cost-effectiveness of interferon gamma-1b in critically ill patients: a secondary analysis of the PREV-HAP trial
Interferon gamma‑1b has been proposed to treat critical illness-induced immunosuppression. We aimed to determine the...
Effects of normal saline versus lactated Ringer’s solution on organ function and inflammatory responses to heatstroke in rats
Effects of normal saline versus lactated Ringer’s solution on organ function and inflammatory responses to heatstroke in rats
Heatstroke is a life-threatening condition characterized by severe hyperthermia and multiple organ dysfunction. Both norma...
Monte Carlo simulations of cefepime in children receiving continuous kidney replacement therapy support continuous infusions for target attainment
Monte Carlo simulations of cefepime in children receiving continuous kidney replacement therapy support continuous infusions for target attainment
Sepsis is a leading cause of acute kidney injury requiring continuous kidney replacement therapy (CKRT) and CKRT can alter...
Recovery of consciousness after acute brain injury: a narrative review
Recovery of consciousness after acute brain injury: a narrative review
Disorders of consciousness (DoC) are frequently encountered in both, acute and chronic brain injuries. In many countries, ...
Remifentanil vs. dexmedetomidine for cardiac surgery patients with noninvasive ventilation intolerance: a multicenter randomized controlled trial
Remifentanil vs. dexmedetomidine for cardiac surgery patients with noninvasive ventilation intolerance: a multicenter randomized controlled trial
The optimal sedative regime for noninvasive ventilation (NIV) intolerance remains uncertain. The present study aimed to as...
Association between red blood cell distribution width and 30-day mortality in critically ill septic patients: a propensity score-matched study
Association between red blood cell distribution width and 30-day mortality in critically ill septic patients: a propensity score-matched study
Sepsis is the leading cause of death worldwide, and a number of biomarkers have been developed for early mortality risk st...
Acute lung injury and post-cardiac arrest syndrome: a narrative review
Acute lung injury and post-cardiac arrest syndrome: a narrative review
Post-cardiac arrest syndrome (PCAS) presents a multifaceted challenge in clinical practice, characterized by severe neurol...
Which factors are associated with acquired weakness in the ICU? An overview of systematic reviews and meta-analyses
Which factors are associated with acquired weakness in the ICU? An overview of systematic reviews and meta-analyses
Intensive care unit-acquired weakness (ICUAW) is common in critically ill patients, characterized by muscle weakness and p...
Impact of sympathetic hyperactivity induced by brain microglial activation on organ damage in sepsis with chronic kidney disease
Impact of sympathetic hyperactivity induced by brain microglial activation on organ damage in sepsis with chronic kidney disease
Sympathetic nerve activity (SNA) plays a central role in the pathogenesis of several diseases such as sepsis and chronic k...
Impacts of three inspiratory muscle training programs on inspiratory muscles strength and endurance among intubated and mechanically ventilated patients with difficult weaning: a multicentre randomised controlled trial
Impacts of three inspiratory muscle training programs on inspiratory muscles strength and endurance among intubated and mechanically ventilated patients with difficult weaning: a multicentre randomised controlled trial
Inspiratory muscle training (IMT) is well-established as a safe option for combating inspiratory muscles weakness in the i...
Nutritional therapy for the prevention of post-intensive care syndrome
Nutritional therapy for the prevention of post-intensive care syndrome
Post-intensive care syndrome (PICS) is a triad of physical, cognitive, and mental impairments that occur during or followi...
Increasing plasma calprotectin (S100A8/A9) is associated with 12-month mortality and unfavourable functional outcome in critically ill COVID-19 patients
Increasing plasma calprotectin (S100A8/A9) is associated with 12-month mortality and unfavourable functional outcome in critically ill COVID-19 patients
Calprotectin (S100A8/A9) is a pro-inflammatory mediator primarily released from neutrophils. Previous studies have reveale...
Normal saline versus Ringer’s solution and critical-illness mortality in acute pancreatitis: a nationwide inpatient database study
Normal saline versus Ringer’s solution and critical-illness mortality in acute pancreatitis: a nationwide inpatient database study
Fluid resuscitation is fundamental in acute pancreatitis (AP) treatment. However, the optimal choice between normal saline...
Determining prognostic indicator for anticoagulant therapy in sepsis-induced disseminated intravascular coagulation
Determining prognostic indicator for anticoagulant therapy in sepsis-induced disseminated intravascular coagulation
There is no reliable indicator that can assess the treatment effect of anticoagulant therapy for sepsis-associated dissemi...
Occurrence of pendelluft during ventilator weaning with T piece correlated with increased mortality in difficult-to-wean patients
Occurrence of pendelluft during ventilator weaning with T piece correlated with increased mortality in difficult-to-wean patients
Difficult-to-wean patients, typically identified as those failing the initial spontaneous breathing trial (SBT), face elev...
Low-flow time and outcomes in hypothermic cardiac arrest patients treated with extracorporeal cardiopulmonary resuscitation: a secondary analysis of a multi-center retrospective cohort study
Low-flow time and outcomes in hypothermic cardiac arrest patients treated with extracorporeal cardiopulmonary resuscitation: a secondary analysis of a multi-center retrospective cohort study
In out-of-hospital cardiac arrest (OHCA) patients with extracorporeal cardiopulmonary resuscitation (ECPR), the associatio...
Hospital and regional variations in intensive care unit admission for patients with invasive mechanical ventilation
Hospital and regional variations in intensive care unit admission for patients with invasive mechanical ventilation
Patients who receive invasive mechanical ventilation (IMV) in the intensive care unit (ICU) have exhibited lower in-hospit...
Case volume and specialization in critically ill emergency patients: a nationwide cohort study in Japanese ICUs
Case volume and specialization in critically ill emergency patients: a nationwide cohort study in Japanese ICUs
Previous studies have explored the association between the number of cases and patient outcomes for critical illnesses suc...
Mechanisms maintaining right ventricular contractility-to-pulmonary arterial elastance ratio in VA ECMO: a retrospective animal data analysis of RV–PA coupling
Mechanisms maintaining right ventricular contractility-to-pulmonary arterial elastance ratio in VA ECMO: a retrospective animal data analysis of RV–PA coupling
To optimize right ventricular–pulmonary coupling during veno-arterial (VA) ECMO weaning, inotropes, vasopressors and...
Recent advances in cardiorespiratory monitoring in acute respiratory distress syndrome patients
Recent advances in cardiorespiratory monitoring in acute respiratory distress syndrome patients
Recent advances on cardiorespiratory monitoring applied in ARDS patients undergoing invasive mechanical ventilation and no...
Hemorrhage and thrombosis in COVID-19-patients supported with extracorporeal membrane oxygenation: an international study based on the COVID-19 critical care consortium
Hemorrhage and thrombosis in COVID-19-patients supported with extracorporeal membrane oxygenation: an international study based on the COVID-19 critical care consortium
Extracorporeal membrane oxygenation (ECMO) is a rescue therapy in patients with severe acute respiratory distress syndrome...
Prognostic nutritional index as a predictive marker for acute kidney injury in adult critical illness population: a systematic review and diagnostic test accuracy meta-analysis
Prognostic nutritional index as a predictive marker for acute kidney injury in adult critical illness population: a systematic review and diagnostic test accuracy meta-analysis
The prognostic nutritional index (PNI), integrating nutrition and inflammation markers, has been increasingly recognized a...
Respiratory drive: a journey from health to disease
Respiratory drive: a journey from health to disease
Respiratory drive is defined as the intensity of respiratory centers output during the breath and is primarily affected by...
Predictors and outcomes of withholding and withdrawal of life-sustaining treatments in intensive care units in Singapore: a multicentre observational study
Predictors and outcomes of withholding and withdrawal of life-sustaining treatments in intensive care units in Singapore: a multicentre observational study
Clinical practice guidelines on limitation of life-sustaining treatments (LST) in the intensive care unit (ICU), in the fo...
Risk factors for arterial catheter failure and complications during critical care hospitalisation: a secondary analysis of a multisite, randomised trial
Risk factors for arterial catheter failure and complications during critical care hospitalisation: a secondary analysis of a multisite, randomised trial
Arterial catheters (ACs) are critical for haemodynamic monitoring and blood sampling but are prone to complications. We in...
From bedside to recovery: exercise therapy for prevention of post-intensive care syndrome
From bedside to recovery: exercise therapy for prevention of post-intensive care syndrome
As advancements in critical care medicine continue to improve Intensive Care Unit (ICU) survival rates, clinical and resea...
Unit-to-unit transfer due to shortage of intensive care beds in Sweden 2015–2019 was associated with a lower risk of death but a longer intensive care stay compared to no transfer: a registry study
Unit-to-unit transfer due to shortage of intensive care beds in Sweden 2015–2019 was associated with a lower risk of death but a longer intensive care stay compared to no transfer: a registry study
Intensive care unit-to-unit transfer due to temporary shortage of beds is increasing in Sweden. Transportation induces pra...
Exploring the therapeutic role of early heparin administration in ARDS management: a MIMIC-IV database analysis
Exploring the therapeutic role of early heparin administration in ARDS management: a MIMIC-IV database analysis
Acute respiratory distress syndrome (ARDS) is a severe respiratory condition characterized by a high mortality rate, the m...
Development and validation of a nomogram to predict the risk of sepsis-associated encephalopathy for septic patients in PICU: a multicenter retrospective cohort study
Development and validation of a nomogram to predict the risk of sepsis-associated encephalopathy for septic patients in PICU: a multicenter retrospective cohort study
Patients with sepsis-associated encephalopathy (SAE) have higher mortality rates and longer ICU stays. Predictors of SAE a...
External validation of the HACOR score and ROX index for predicting treatment failure in patients with coronavirus disease 2019 pneumonia managed on high-flow nasal cannula therapy: a multicenter retrospective observational study in Japan
External validation of the HACOR score and ROX index for predicting treatment failure in patients with coronavirus disease 2019 pneumonia managed on high-flow nasal cannula therapy: a multicenter retrospective observational study in Japan
The HACOR score for predicting treatment failure includes vital signs and acid–base balance factors, whereas the ROX...
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