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Predictors and outcomes of withholding and withdrawal of life-sustaining treatments in intensive care units in Singapore: a multicentre observational study
Predictors and outcomes of withholding and withdrawal of life-sustaining treatments in intensive care units in Singapore: a multicentre observational study
Clinical practice guidelines on limitation of life-sustaining treatments (LST) in the intensive care unit (ICU), in the fo...
Risk factors for arterial catheter failure and complications during critical care hospitalisation: a secondary analysis of a multisite, randomised trial
Risk factors for arterial catheter failure and complications during critical care hospitalisation: a secondary analysis of a multisite, randomised trial
Arterial catheters (ACs) are critical for haemodynamic monitoring and blood sampling but are prone to complications. We in...
From bedside to recovery: exercise therapy for prevention of post-intensive care syndrome
From bedside to recovery: exercise therapy for prevention of post-intensive care syndrome
As advancements in critical care medicine continue to improve Intensive Care Unit (ICU) survival rates, clinical and resea...
Unit-to-unit transfer due to shortage of intensive care beds in Sweden 2015–2019 was associated with a lower risk of death but a longer intensive care stay compared to no transfer: a registry study
Unit-to-unit transfer due to shortage of intensive care beds in Sweden 2015–2019 was associated with a lower risk of death but a longer intensive care stay compared to no transfer: a registry study
Intensive care unit-to-unit transfer due to temporary shortage of beds is increasing in Sweden. Transportation induces pra...
Exploring the therapeutic role of early heparin administration in ARDS management: a MIMIC-IV database analysis
Exploring the therapeutic role of early heparin administration in ARDS management: a MIMIC-IV database analysis
Acute respiratory distress syndrome (ARDS) is a severe respiratory condition characterized by a high mortality rate, the m...
Development and validation of a nomogram to predict the risk of sepsis-associated encephalopathy for septic patients in PICU: a multicenter retrospective cohort study
Development and validation of a nomogram to predict the risk of sepsis-associated encephalopathy for septic patients in PICU: a multicenter retrospective cohort study
Patients with sepsis-associated encephalopathy (SAE) have higher mortality rates and longer ICU stays. Predictors of SAE a...
External validation of the HACOR score and ROX index for predicting treatment failure in patients with coronavirus disease 2019 pneumonia managed on high-flow nasal cannula therapy: a multicenter retrospective observational study in Japan
External validation of the HACOR score and ROX index for predicting treatment failure in patients with coronavirus disease 2019 pneumonia managed on high-flow nasal cannula therapy: a multicenter retrospective observational study in Japan
The HACOR score for predicting treatment failure includes vital signs and acid–base balance factors, whereas the ROX...
Association between regional critical care capacity and the incidence of invasive mechanical ventilation for coronavirus disease 2019: a population-based cohort study
Association between regional critical care capacity and the incidence of invasive mechanical ventilation for coronavirus disease 2019: a population-based cohort study
Coronavirus disease 2019 (COVID-19) has exposed critical care supply shortages worldwide. This study aimed to investigate ...
Chest CT findings in severe acute respiratory distress syndrome requiring V-V ECMO: J-CARVE registry
Chest CT findings in severe acute respiratory distress syndrome requiring V-V ECMO: J-CARVE registry
Chest computed tomography findings are helpful for understanding the pathophysiology of severe acute respiratory distress ...
Efficacy of permissive underfeeding for critically ill patients: an updated systematic review and trial sequential meta-analysis
Efficacy of permissive underfeeding for critically ill patients: an updated systematic review and trial sequential meta-analysis
Our previous study in 2011 concluded that permissive underfeeding may improve outcomes in patients receiving parenteral nu...
Limitation of life sustaining measures in neurocritical care: sex, timing, and advance directive
Limitation of life sustaining measures in neurocritical care: sex, timing, and advance directive
The limitation of life sustaining treatments (LLST) causes ethical dilemmas even in patients faced with poor prognosis, wh...
Post-intensive care syndrome follow-up system after hospital discharge: a narrative review
Post-intensive care syndrome follow-up system after hospital discharge: a narrative review
Post-intensive care syndrome (PICS) is the long-lasting impairment of physical functions, cognitive functions, and mental ...
Development of quality indicators for palliative care in intensive care units and pilot testing them via electronic medical record review
Development of quality indicators for palliative care in intensive care units and pilot testing them via electronic medical record review
Patients in intensive care units (ICUs) often require quality palliative care for relief from various types of suffering. ...
Mechanical circulatory support in cardiogenic shock
Mechanical circulatory support in cardiogenic shock
Cardiogenic shock is a complex and diverse pathological condition characterized by reduced myocardial contractility. The g...
Higher levels of circulating desphospho-uncarboxylated matrix Gla protein over time are associated with worse survival: the prospective Maastricht Intensive Care COVID cohort
Higher levels of circulating desphospho-uncarboxylated matrix Gla protein over time are associated with worse survival: the prospective Maastricht Intensive Care COVID cohort
Extra-hepatic vitamin K-status, measured by dephosphorylated uncarboxylated matrix Gla protein (dp-ucMGP), maintains vascu...
Functional intervention following cardiac surgery to prevent postoperative delirium in older patients (FEEL WELL study)
Functional intervention following cardiac surgery to prevent postoperative delirium in older patients (FEEL WELL study)
Postoperative delirium is a common complication in patients after cardiac surgery, especially in older patients, and can m...
Light and dark sides of evidence-based and supportive ICU care for patients undergoing extracorporeal membrane oxygenation
Light and dark sides of evidence-based and supportive ICU care for patients undergoing extracorporeal membrane oxygenation
Authors and AffiliationsNon-Profit Organization ICU Collaboration Network (ICON), 2-15-13 Hongo, Bunkyo-Ku, Tokyo, 113-003...
Intensive care unit mortality and cost-effectiveness associated with intensivist staffing: a Japanese nationwide observational study
Intensive care unit mortality and cost-effectiveness associated with intensivist staffing: a Japanese nationwide observational study
Japan has four types of intensive care units (ICUs) that are divided into two categories according to the management fee c...
Prognostic value of oxygen saturation index trajectory phenotypes on ICU mortality in mechanically ventilated patients: a multi-database retrospective cohort study
Prognostic value of oxygen saturation index trajectory phenotypes on ICU mortality in mechanically ventilated patients: a multi-database retrospective cohort study
Heterogeneity among critically ill patients undergoing invasive mechanical ventilation (IMV) treatment could result in hig...
Visualizing the dynamic mechanical power and time burden of mechanical ventilation patients: an analysis of the MIMIC-IV database
Visualizing the dynamic mechanical power and time burden of mechanical ventilation patients: an analysis of the MIMIC-IV database
Limiting driving pressure and mechanical power is associated with reduced mortality risk in both patients with and without...
Optimized ventilation power to avoid VILI
Optimized ventilation power to avoid VILI
The effort to minimize VILI risk must be multi-pronged. The need to adequately ventilate, a key determinant of hazardous p...
The optimal dose of mobilisation therapy in the ICU: a prospective cohort study
The optimal dose of mobilisation therapy in the ICU: a prospective cohort study
This study aimed to assess the impact of duration of early mobilisation on survivors of critical illness. The hypothesis w...
Variation in coagulation factor activity levels cause discrepancies between activated partial thromboplastin time and anti-Xa activity for heparin monitoring: a retrospective observational study
Variation in coagulation factor activity levels cause discrepancies between activated partial thromboplastin time and anti-Xa activity for heparin monitoring: a retrospective observational study
Unfractionated heparin (UFH) is primarily monitored using activated partial thromboplastin time (APTT). However, the recen...
Prolonged use of neuromuscular blocking agents is associated with increased long-term mortality in mechanically ventilated medical ICU patients: a retrospective cohort study
Prolonged use of neuromuscular blocking agents is associated with increased long-term mortality in mechanically ventilated medical ICU patients: a retrospective cohort study
Neuromuscular blockade agents (NMBAs) can be used to facilitate mechanical ventilation in critically ill patients. Accumul...
Translation of patients’ advance directives in intensive care units: are we there yet?
Translation of patients’ advance directives in intensive care units: are we there yet?
This review examined studies regarding the implementation and translation of patients’ advance directives (AD) in in...
Efficacy of therapeutic drug monitoring-based antibiotic regimen in critically ill patients: a systematic review and meta-analysis of randomized controlled trials
Efficacy of therapeutic drug monitoring-based antibiotic regimen in critically ill patients: a systematic review and meta-analysis of randomized controlled trials
The efficacy of therapeutic drug monitoring (TDM)-based antimicrobial dosing optimization strategies on pharmacokinetics/p...
Lacosamide dosing in patients receiving continuous renal replacement therapy
Lacosamide dosing in patients receiving continuous renal replacement therapy
Lacosamide is one of the anticonvulsants used in critically ill patients. This study aimed to suggest appropriate lacosami...
A deep learning model for predicting multidrug-resistant organism infection in critically ill patients
A deep learning model for predicting multidrug-resistant organism infection in critically ill patients
This study aimed to apply the backpropagation neural network (BPNN) to develop a model for predicting multidrug-resistant ...
Concerns with the revised Japanese recommendation for administering vitamin C to septic patients
Concerns with the revised Japanese recommendation for administering vitamin C to septic patients
Guideline committee of The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020; Japanese ...
Efficacy, safety, and pharmacokinetics of MR13A11A, a generic of remifentanil, for pain management of Japanese patients in the intensive care unit: a double-blinded, fentanyl-controlled, randomized, non-inferiority phase 3 study
Efficacy, safety, and pharmacokinetics of MR13A11A, a generic of remifentanil, for pain management of Japanese patients in the intensive care unit: a double-blinded, fentanyl-controlled, randomized, non-inferiority phase 3 study
The aims of this study were to evaluate the efficacy, safety, and pharmacokinetics (PK) of continuous intravenous administ...
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