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Real-world effectiveness of dimethyl fumarate versus fingolimod in a cohort of patients with multiple sclerosis using standardized, quantitative outcome metrics
Real-world effectiveness of dimethyl fumarate versus fingolimod in a cohort of patients with multiple sclerosis using standardized, quantitative outcome metrics
BackgroundPrior studies suggest comparable effectiveness of dimethyl fumarate (DMF) and fingolimod (FTY) in multiple scler...
Cervical Spinal Cord Atrophy can be Accurately Quantified Using Head Images
Cervical Spinal Cord Atrophy can be Accurately Quantified Using Head Images
BackgroundSpinal cord atrophy provides a clinically relevant metric for monitoring MS. However, the spinal cord is imaged ...
Serum NfL levels in the first five years predict 10-year thalamic fraction in patients with MS
Serum NfL levels in the first five years predict 10-year thalamic fraction in patients with MS
BackgroundSerum neurofilament light chain (sNfL) levels are associated with relapses, MRI lesions, and brain volume in mul...
Cerebrospinal fluid evaluation in patients with progressive motor impairment due to critical central nervous system demyelinating lesions
Cerebrospinal fluid evaluation in patients with progressive motor impairment due to critical central nervous system demyelinating lesions
BackgroundElevated intrathecal immunoglobulin G (IgG; oligoclonal bands (OCBs)) or IgG in people with progressive motor im...
Let's talk about sex(ual) wellbeing! Staff perceptions of implementing a novel service for people with Multiple Sclerosis
Let's talk about sex(ual) wellbeing! Staff perceptions of implementing a novel service for people with Multiple Sclerosis
BackgroundIn people with multiple sclerosis (PwMS), a complex interplay of neurological dysfunction, polypharmacy and psyc...
Functional intermuscular reduction in spasticity for people with multiple sclerosis
Functional intermuscular reduction in spasticity for people with multiple sclerosis
BackgroundEighty-five percent of people with multiple sclerosis (MS) incur gait impairments debilitating enough to signifi...
Central Nervous System Demyelination Related to Tumour Necrosis Factor Alpha Inhibitor
Central Nervous System Demyelination Related to Tumour Necrosis Factor Alpha Inhibitor
BackgroundAn association between tumour necrosis factor alpha (TNF-α) inhibitors exposure and central nervous system (CNS)...
Usefulness of two-dimensional measurements for the evaluation of brain volume and disability in multiple sclerosis
Usefulness of two-dimensional measurements for the evaluation of brain volume and disability in multiple sclerosis
BackgroundTwo-dimensional (2D) measures have been proposed as potential proxies for whole-brain volume in multiple scleros...
Tolerability and Safety of Switching from Rituximab to Ocrelizumab: Evaluating Factors Associated with Infusion Related Reactions
Tolerability and Safety of Switching from Rituximab to Ocrelizumab: Evaluating Factors Associated with Infusion Related Reactions
BackgroundOcrelizumab and rituximab are frequently used treatments for multiple sclerosis (MS). Data on switching from rit...
Infectious risk in multiple sclerosis patients treated with disease-modifying therapies: A three-year observational cohort study
Infectious risk in multiple sclerosis patients treated with disease-modifying therapies: A three-year observational cohort study
BackgroundThe disease-modifying therapies (DMTs) largely used in multiple sclerosis (MS) may result in higher infectious r...
Season of birth is associated with multiple sclerosis and disease severity
Season of birth is associated with multiple sclerosis and disease severity
BackgroundThe latitude gradient in multiple sclerosis incidence indicates that low sun exposure and therefore vitamin D de...
The use of OCT in good visual acuity MOGAD and AQP4-NMOSD patients; with and without optic neuritis
The use of OCT in good visual acuity MOGAD and AQP4-NMOSD patients; with and without optic neuritis
Myelin oligodendrocyte-antibody-associated disease (MOGAD) often presents with severe optic neuritis (ON) but tends to rec...
Structural and functional markers of optic nerve damage in myelin oligodendrocyte glycoprotein antibody-associated optic neuritis
Structural and functional markers of optic nerve damage in myelin oligodendrocyte glycoprotein antibody-associated optic neuritis
BackgroundOptic neuritis (ON) occurs in immune-mediated disorders including multiple sclerosis (MS), aquaporin-4 antibody-...
The results of a 24-month controlled, prospective study of relapsing multiple sclerosis patients at risk for progressive multifocal encephalopathy, who switched from prolonged use of natalizumab to teriflunomide
The results of a 24-month controlled, prospective study of relapsing multiple sclerosis patients at risk for progressive multifocal encephalopathy, who switched from prolonged use of natalizumab to teriflunomide
BackgroundNatalizumab (NTZ) is a highly effective disease modifying treatment for relapsing multiple sclerosis (RMS), but ...
Long-term efficacy and safety of three times weekly dosing regimen of glatiramer acetate in relapsing multiple sclerosis patients: Seven-year results of the Glatiramer Acetate Low-frequency Administration (GALA) open-label extension study
Long-term efficacy and safety of three times weekly dosing regimen of glatiramer acetate in relapsing multiple sclerosis patients: Seven-year results of the Glatiramer Acetate Low-frequency Administration (GALA) open-label extension study
ObjectiveDescribe the long-term outcomes of early-start (ES) and delayed-start (DS) glatiramer acetate 40 mg/mL treatment ...
Feasibility of cognitive rehabilitation in patients with advanced multiple sclerosis: A pilot study
Feasibility of cognitive rehabilitation in patients with advanced multiple sclerosis: A pilot study
BackgroundThe feasibility of cognitive rehabilitation is rarely investigated in patients with advanced multiple sclerosis....
Multiple Sclerosis International Federation guideline methodology for off-label treatments for multiple sclerosis
Multiple Sclerosis International Federation guideline methodology for off-label treatments for multiple sclerosis
BackgroundA total of 2.8 million people are living with multiple sclerosis and due to disparities in access to medicines, ...
CSF neurofilament light chain predicts 10-year clinical and radiologic worsening in multiple sclerosis
CSF neurofilament light chain predicts 10-year clinical and radiologic worsening in multiple sclerosis
BackgroundNeurofilament light chain (NfL) is an attractive biomarker of disease activity and progression in MS, but there ...
Etiological research in pediatric multiple sclerosis: A tool to assess environmental exposures (PEDiatric Italian Genetic and enviRonment ExposurE Questionnaire)
Etiological research in pediatric multiple sclerosis: A tool to assess environmental exposures (PEDiatric Italian Genetic and enviRonment ExposurE Questionnaire)
BackgroundThe etiology of pediatric-onset multiple sclerosis is unknown although putative genetic and environmental factor...
Evaluation of short-term safety of COVID-19 vaccines in patients with multiple sclerosis from Latin America
Evaluation of short-term safety of COVID-19 vaccines in patients with multiple sclerosis from Latin America
BackgroundTo date, there are no data available on the safety of COVID-19 vaccines in Latin American patients with Multiple...
Determining the best window for BNT162b2 mRNA vaccination for SARS-CoV-2 in patients with multiple sclerosis receiving anti-CD20 therapy
Determining the best window for BNT162b2 mRNA vaccination for SARS-CoV-2 in patients with multiple sclerosis receiving anti-CD20 therapy
We studied the serologic response to the BNT162b2 mRNA vaccine at four weeks after the second dose in patients with RRMS t...
Diagnostic value of gadolinium contrast administration for spinal cord magnetic resonance imaging in multiple sclerosis patients and correlative markers of lesion enhancement
Diagnostic value of gadolinium contrast administration for spinal cord magnetic resonance imaging in multiple sclerosis patients and correlative markers of lesion enhancement
BackgroundMagnetic resonance imaging is essential for monitoring people with multiple sclerosis, but the diagnostic value ...
Diagnostic value of aquaporin-4-IgG live cell based assay in neuromyelitis optica spectrum disorders
Diagnostic value of aquaporin-4-IgG live cell based assay in neuromyelitis optica spectrum disorders
ObjectiveDetermine the utility of aquaporin 4 IgG (AQP4-IgG) testing (live cell-based assay) for Neuromyelitis Optica Spec...
Clinical features and outcomes of COVID-19 despite SARS-CoV-2 vaccination in people with multiple sclerosis
Clinical features and outcomes of COVID-19 despite SARS-CoV-2 vaccination in people with multiple sclerosis
BackgroundSeveral studies have demonstrated reduced serological response to vaccines in patients treated with anti-CD20 ag...
A multisite randomized controlled trial of two group education programs for fatigue in multiple sclerosis: Very long term (5–6 year) follow-up at one site
A multisite randomized controlled trial of two group education programs for fatigue in multiple sclerosis: Very long term (5–6 year) follow-up at one site
BackgroundA multicomponent group MS fatigue self-management program reduced fatigue impact compared to a rigorous control ...
Cardiorespiratory fitness and moderate-to-vigorous physical activity in older adults with multiple sclerosis
Cardiorespiratory fitness and moderate-to-vigorous physical activity in older adults with multiple sclerosis
BackgroundCardiorespiratory fitness (VO2peak) may be a modifiable indicator of health status and well-being in older adult...
Incidence of malignancy in multiple sclerosis: A cohort study in the Danish Multiple Sclerosis Registry
Incidence of malignancy in multiple sclerosis: A cohort study in the Danish Multiple Sclerosis Registry
BackgroundThe association between multiple sclerosis and malignancy is controversial and a current appraisal is needed.Obj...
Clinical Significance of Myelin Oligodendrocyte Glycoprotein Autoantibodies in Patients with Typical MS Lesions on MRI
Clinical Significance of Myelin Oligodendrocyte Glycoprotein Autoantibodies in Patients with Typical MS Lesions on MRI
BackgroundMyelin-oligodendrocyte-glycoprotein (MOG)-IgG-positivity in patients with typical MS lesions on MRI may lead to ...
Effects of melatonin on sleep disturbances in multiple sclerosis: A randomized, controlled pilot study
Effects of melatonin on sleep disturbances in multiple sclerosis: A randomized, controlled pilot study
BackgroundSleep disturbances are commonly reported by people with multiple sclerosis (PwMS). However, optimal management o...
Siponimod (BAF312) penetrates, distributes, and acts in the central nervous system: Preclinical insights
Siponimod (BAF312) penetrates, distributes, and acts in the central nervous system: Preclinical insights
BackgroundSiponimod (BAF312), a selective S1P1/S1P5 agonist, reduces disability progression in secondary progressive MS. R...
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