SCI时时刷

search
+
TDP43 pathology in chronic traumatic encephalopathy retinas
TDP43 pathology in chronic traumatic encephalopathy retinas
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repetitive head trauma. Brain pathol...
A toxic gain-of-function mechanism in C9orf72 ALS impairs the autophagy-lysosome pathway in neurons
A toxic gain-of-function mechanism in C9orf72 ALS impairs the autophagy-lysosome pathway in neurons
Motor neurons (MNs), which are primarily affected in amyotrophic lateral sclerosis (ALS), are a specialized type of neuron...
Proteomic analysis across patient iPSC-based models and human post-mortem hippocampal tissue reveals early cellular dysfunction and progression of Alzheimer’s disease pathogenesis
Proteomic analysis across patient iPSC-based models and human post-mortem hippocampal tissue reveals early cellular dysfunction and progression of Alzheimer’s disease pathogenesis
The hippocampus is a primary region affected in Alzheimer’s disease (AD). Because AD postmortem brain tissue is not ...
Amygdala granular fuzzy astrocytes are independently associated with both LATE neuropathologic change and argyrophilic grains: a study of Japanese series with a low to moderate Braak stage
Amygdala granular fuzzy astrocytes are independently associated with both LATE neuropathologic change and argyrophilic grains: a study of Japanese series with a low to moderate Braak stage
Arnold SJ, Dugger BN, Beach TG (2013) TDP-43 deposition in prospectively followed, cognitively normal elderly individuals:...
Translocator protein (18kDA) (TSPO) marks mesenchymal glioblastoma cell populations characterized by elevated numbers of tumor-associated macrophages
Translocator protein (18kDA) (TSPO) marks mesenchymal glioblastoma cell populations characterized by elevated numbers of tumor-associated macrophages
TSPO is a promising novel tracer target for positron-emission tomography (PET) imaging of brain tumors. However, due to th...
Pyrroloquinoline quinone drives ATP synthesis in vitro and in vivo and provides retinal ganglion cell neuroprotection
Pyrroloquinoline quinone drives ATP synthesis in vitro and in vivo and provides retinal ganglion cell neuroprotection
Retinal ganglion cells are highly metabolically active requiring strictly regulated metabolism and functional mitochondria...
Understanding the key features of the spontaneous formation of bona fide prions through a novel methodology that enables their swift and consistent generation
Understanding the key features of the spontaneous formation of bona fide prions through a novel methodology that enables their swift and consistent generation
Among transmissible spongiform encephalopathies or prion diseases affecting humans, sporadic forms such as sporadic Creutz...
Molecular profiling of pre- and post-treatment pediatric high-grade astrocytomas reveals acquired increased tumor mutation burden in a subset of recurrences
Molecular profiling of pre- and post-treatment pediatric high-grade astrocytomas reveals acquired increased tumor mutation burden in a subset of recurrences
Diffuse gliomas are a heterogeneous category of primary central nervous system tumors. Due to their infiltrative growth pr...
Low-intensity open-field blast exposure effects on neurovascular unit ultrastructure in mice
Low-intensity open-field blast exposure effects on neurovascular unit ultrastructure in mice
Mild traumatic brain injury (mTBI) induced by low-intensity blast (LIB) is a serious health problem affecting military ser...
Abnormal accumulation of extracellular vesicles in hippocampal dystrophic axons and regulation by the primary cilia in Alzheimer’s disease
Abnormal accumulation of extracellular vesicles in hippocampal dystrophic axons and regulation by the primary cilia in Alzheimer’s disease
Dystrophic neurites (DNs) are abnormal axons and dendrites that are swollen or deformed in various neuropathological condi...
Novel histotypes of sporadic Creutzfeldt–Jakob disease linked to 129MV genotype
Novel histotypes of sporadic Creutzfeldt–Jakob disease linked to 129MV genotype
The MV1 and MV2 subtypes of sporadic Creutzfeldt–Jakob disease (sCJD) are linked to the heterozygous methionine (M)/...
MGMT methylation pattern of long-term and short-term survivors of glioblastoma reveals CpGs of the enhancer region to be of high prognostic value
MGMT methylation pattern of long-term and short-term survivors of glioblastoma reveals CpGs of the enhancer region to be of high prognostic value
Treatment with the alkylating agent temozolomide is known to be prognostically beneficial in a subset of glioblastoma pati...
A neuropathologic feature of brain aging: multi-lumen vascular profiles
A neuropathologic feature of brain aging: multi-lumen vascular profiles
Cerebrovascular pathologies other than frank infarctions are commonly seen in aged brains. Here, we focus on multi-lumen v...
Repeat length of C9orf72-associated glycine–alanine polypeptides affects their toxicity
Repeat length of C9orf72-associated glycine–alanine polypeptides affects their toxicity
G4C2 hexanucleotide repeat expansions in a non-coding region of the C9orf72 gene are the most common cause of familial amy...
Traumatic brain injury induces TDP-43 mislocalization and neurodegenerative effects in tissue distal to the primary injury site in a non-transgenic mouse
Traumatic brain injury induces TDP-43 mislocalization and neurodegenerative effects in tissue distal to the primary injury site in a non-transgenic mouse
Traumatic brain injury (TBI) initiates tissue and cellular damage to the brain that is immediately followed by secondary i...
Diagnostic accuracy of a minimal immunohistochemical panel in at/rt molecular subtyping, correlated to dna-methylation profiling
Diagnostic accuracy of a minimal immunohistochemical panel in at/rt molecular subtyping, correlated to dna-methylation profiling
Atypical Teratoid/Rhabdoid Tumors (AT/RT) are malignant pediatric tumors of the Central Nervous System (CNS) and are molec...
Inhibition of acid sphingomyelinase reduces reactive astrocyte secretion of mitotoxic extracellular vesicles and improves Alzheimer’s disease pathology in the 5xFAD mouse
Inhibition of acid sphingomyelinase reduces reactive astrocyte secretion of mitotoxic extracellular vesicles and improves Alzheimer’s disease pathology in the 5xFAD mouse
In Alzheimer’s disease (AD), reactive astrocytes produce extracellular vesicles (EVs) that affect mitochondria in ne...
Dissection of transcriptomic and epigenetic heterogeneity of grade 4 gliomas: implications for prognosis
Dissection of transcriptomic and epigenetic heterogeneity of grade 4 gliomas: implications for prognosis
Grade 4 glioma is the most aggressive and currently incurable brain tumor with a median survival of one year in adult pati...
Selective neuroimmune modulation by type I interferon drives neuropathology and neurologic dysfunction following traumatic brain injury
Selective neuroimmune modulation by type I interferon drives neuropathology and neurologic dysfunction following traumatic brain injury
Accumulating evidence suggests that type I interferon (IFN-I) signaling is a key contributor to immune cell-mediated neuro...
Cathepsin B abundance, activity and microglial localisation in Alzheimer’s disease-Down syndrome and early onset Alzheimer’s disease; the role of elevated cystatin B
Cathepsin B abundance, activity and microglial localisation in Alzheimer’s disease-Down syndrome and early onset Alzheimer’s disease; the role of elevated cystatin B
Cathepsin B is a cysteine protease that is implicated in multiple aspects of Alzheimer’s disease pathogenesis. The e...
A novel ELOVL4 variant, L168S, causes early childhood-onset Spinocerebellar ataxia-34 and retinal dysfunction: a case report
A novel ELOVL4 variant, L168S, causes early childhood-onset Spinocerebellar ataxia-34 and retinal dysfunction: a case report
Spinocerebellar ataxia 34 (SCA34) is an autosomal dominant inherited disease characterized by age-related cerebellar degen...
The specific DNA methylation landscape in focal cortical dysplasia ILAE type 3D
The specific DNA methylation landscape in focal cortical dysplasia ILAE type 3D
Focal Cortical Dysplasia (FCD) is a frequent cause of drug-resistant focal epilepsy in children and young adults. The inte...
A heterozygous splicing variant IVS9-7A > T in intron 9 of the MAPT gene in a patient with right-temporal variant frontotemporal dementia with atypical 4 repeat tauopathy
A heterozygous splicing variant IVS9-7A > T in intron 9 of the MAPT gene in a patient with right-temporal variant frontotemporal dementia with atypical 4 repeat tauopathy
Right temporal variant frontotemporal dementia, also called right-predominant semantic dementia, often has an unclear posi...
Hypoxic oligodendrocyte precursor cell-derived VEGFA is associated with blood–brain barrier impairment
Hypoxic oligodendrocyte precursor cell-derived VEGFA is associated with blood–brain barrier impairment
Cerebral small vessel disease is characterised by decreased cerebral blood flow and blood–brain barrier impairments ...
Human Alzheimer’s disease reactive astrocytes exhibit a loss of homeostastic gene expression
Human Alzheimer’s disease reactive astrocytes exhibit a loss of homeostastic gene expression
Astrocytes are one of the brain’s major cell types and are responsible for maintaining neuronal homeostasis via regu...
Decoding key cell sub-populations and molecular alterations in glioblastoma at recurrence by single-cell analysis
Decoding key cell sub-populations and molecular alterations in glioblastoma at recurrence by single-cell analysis
Glioblastoma (GBM) is the most frequent malignant brain tumor, the relapse of which is unavoidable following standard trea...
Presymptomatic and early pathological features of MAPT-associated frontotemporal lobar degeneration
Presymptomatic and early pathological features of MAPT-associated frontotemporal lobar degeneration
Early pathological features of frontotemporal lobar degeneration (FTLD) due to MAPT pathogenic variants (FTLD-MAPT) are un...
Mitochondrial DNA mutations in Medulloblastoma
Mitochondrial DNA mutations in Medulloblastoma
To date, several studies on genomic events underlying medulloblastoma (MB) biology have expanded our understanding of this...
Three dimensional evaluation of cerebrovascular density and branching in chronic traumatic encephalopathy
Three dimensional evaluation of cerebrovascular density and branching in chronic traumatic encephalopathy
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with exposure to repetitive head impacts ...
Ferroptosis induces detrimental effects in chronic EAE and its implications for progressive MS
Ferroptosis induces detrimental effects in chronic EAE and its implications for progressive MS
Ferroptosis is a form of lipid peroxidation-mediated cell death and damage triggered by excess iron and insufficiency in t...
阅读更多
format_indent_increase