SCI时时刷

search
TDP43 pathology in chronic traumatic encephalopathy retinas
TDP43 pathology in chronic traumatic encephalopathy retinas
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repetitive head trauma. Brain pathol...
A toxic gain-of-function mechanism in C9orf72 ALS impairs the autophagy-lysosome pathway in neurons
A toxic gain-of-function mechanism in C9orf72 ALS impairs the autophagy-lysosome pathway in neurons
Motor neurons (MNs), which are primarily affected in amyotrophic lateral sclerosis (ALS), are a specialized type of neuron...
Pyrroloquinoline quinone drives ATP synthesis in vitro and in vivo and provides retinal ganglion cell neuroprotection
Pyrroloquinoline quinone drives ATP synthesis in vitro and in vivo and provides retinal ganglion cell neuroprotection
Retinal ganglion cells are highly metabolically active requiring strictly regulated metabolism and functional mitochondria...
Low-intensity open-field blast exposure effects on neurovascular unit ultrastructure in mice
Low-intensity open-field blast exposure effects on neurovascular unit ultrastructure in mice
Mild traumatic brain injury (mTBI) induced by low-intensity blast (LIB) is a serious health problem affecting military ser...
Novel histotypes of sporadic Creutzfeldt–Jakob disease linked to 129MV genotype
Novel histotypes of sporadic Creutzfeldt–Jakob disease linked to 129MV genotype
The MV1 and MV2 subtypes of sporadic Creutzfeldt–Jakob disease (sCJD) are linked to the heterozygous methionine (M)/...
A neuropathologic feature of brain aging: multi-lumen vascular profiles
A neuropathologic feature of brain aging: multi-lumen vascular profiles
Cerebrovascular pathologies other than frank infarctions are commonly seen in aged brains. Here, we focus on multi-lumen v...
Repeat length of C9orf72-associated glycine–alanine polypeptides affects their toxicity
Repeat length of C9orf72-associated glycine–alanine polypeptides affects their toxicity
G4C2 hexanucleotide repeat expansions in a non-coding region of the C9orf72 gene are the most common cause of familial amy...
Dissection of transcriptomic and epigenetic heterogeneity of grade 4 gliomas: implications for prognosis
Dissection of transcriptomic and epigenetic heterogeneity of grade 4 gliomas: implications for prognosis
Grade 4 glioma is the most aggressive and currently incurable brain tumor with a median survival of one year in adult pati...
A novel ELOVL4 variant, L168S, causes early childhood-onset Spinocerebellar ataxia-34 and retinal dysfunction: a case report
A novel ELOVL4 variant, L168S, causes early childhood-onset Spinocerebellar ataxia-34 and retinal dysfunction: a case report
Spinocerebellar ataxia 34 (SCA34) is an autosomal dominant inherited disease characterized by age-related cerebellar degen...
The specific DNA methylation landscape in focal cortical dysplasia ILAE type 3D
The specific DNA methylation landscape in focal cortical dysplasia ILAE type 3D
Focal Cortical Dysplasia (FCD) is a frequent cause of drug-resistant focal epilepsy in children and young adults. The inte...
Hypoxic oligodendrocyte precursor cell-derived VEGFA is associated with blood–brain barrier impairment
Hypoxic oligodendrocyte precursor cell-derived VEGFA is associated with blood–brain barrier impairment
Cerebral small vessel disease is characterised by decreased cerebral blood flow and blood–brain barrier impairments ...
Human Alzheimer’s disease reactive astrocytes exhibit a loss of homeostastic gene expression
Human Alzheimer’s disease reactive astrocytes exhibit a loss of homeostastic gene expression
Astrocytes are one of the brain’s major cell types and are responsible for maintaining neuronal homeostasis via regu...
Decoding key cell sub-populations and molecular alterations in glioblastoma at recurrence by single-cell analysis
Decoding key cell sub-populations and molecular alterations in glioblastoma at recurrence by single-cell analysis
Glioblastoma (GBM) is the most frequent malignant brain tumor, the relapse of which is unavoidable following standard trea...
Presymptomatic and early pathological features of MAPT-associated frontotemporal lobar degeneration
Presymptomatic and early pathological features of MAPT-associated frontotemporal lobar degeneration
Early pathological features of frontotemporal lobar degeneration (FTLD) due to MAPT pathogenic variants (FTLD-MAPT) are un...
Mitochondrial DNA mutations in Medulloblastoma
Mitochondrial DNA mutations in Medulloblastoma
To date, several studies on genomic events underlying medulloblastoma (MB) biology have expanded our understanding of this...
Three dimensional evaluation of cerebrovascular density and branching in chronic traumatic encephalopathy
Three dimensional evaluation of cerebrovascular density and branching in chronic traumatic encephalopathy
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with exposure to repetitive head impacts ...
Ferroptosis induces detrimental effects in chronic EAE and its implications for progressive MS
Ferroptosis induces detrimental effects in chronic EAE and its implications for progressive MS
Ferroptosis is a form of lipid peroxidation-mediated cell death and damage triggered by excess iron and insufficiency in t...