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CNS neuroblastoma, FOXR2-activated and its mimics: a relevant panel approach for work-up and accurate diagnosis of this rare neoplasm
CNS neuroblastoma, FOXR2-activated and its mimics: a relevant panel approach for work-up and accurate diagnosis of this rare neoplasm
Jones D, Ismer B, Schrimpf D, Reuss D, Stichel D, Casalini B, Schittenhelm J, Frank S, Boldt H, Winther-Kristensen B, Sehe...
Different MAPT haplotypes influence expression of total MAPT in postmortem brain tissue
Different MAPT haplotypes influence expression of total MAPT in postmortem brain tissue
The MAPT gene, encoding the microtubule-associated protein tau on chromosome 17q21.31, is result of an inversion polymorph...
Roles of neuropathology-associated reactive astrocytes: a systematic review
Roles of neuropathology-associated reactive astrocytes: a systematic review
In the contexts of aging, injury, or neuroinflammation, activated microglia signaling with TNF-α, IL-1α, and C1q...
Loss of MBNL1-mediated retrograde BDNF signaling in the myotonic dystrophy brain
Loss of MBNL1-mediated retrograde BDNF signaling in the myotonic dystrophy brain
Reduced brain volume including atrophy in grey and white matter is commonly seen in myotonic dystrophy type 1 (DM1). DM1 i...
A single mild juvenile TBI in male mice leads to regional brain tissue abnormalities at 12 months of age that correlate with cognitive impairment at the middle age
A single mild juvenile TBI in male mice leads to regional brain tissue abnormalities at 12 months of age that correlate with cognitive impairment at the middle age
Traumatic brain injury (TBI) has the highest incidence amongst the pediatric population and its mild severity represents t...
An integrated genetic analysis of epileptogenic brain malformed lesions
An integrated genetic analysis of epileptogenic brain malformed lesions
Focal cortical dysplasia is the most common malformation during cortical development, sometimes excised by epilepsy surger...
Spontaneous intracerebral haemorrhage associated with early-onset cerebral amyloid angiopathy and Alzheimer’s disease neuropathological changes five decades after cadaveric dura mater graft
Spontaneous intracerebral haemorrhage associated with early-onset cerebral amyloid angiopathy and Alzheimer’s disease neuropathological changes five decades after cadaveric dura mater graft
Cerebral amyloid angiopathy (CAA) is a small vessel disease, causing spontaneous intracerebral hemorrhage (ICH) in the eld...
Monocyte-derived cells invade brain parenchyma and amyloid plaques in human Alzheimer’s disease hippocampus
Monocyte-derived cells invade brain parenchyma and amyloid plaques in human Alzheimer’s disease hippocampus
Microglia are brain-resident myeloid cells and play a major role in the innate immune responses of the CNS and the pathoge...
Bi-allelic variations in CRB2, encoding the crumbs cell polarity complex component 2, lead to non-communicating hydrocephalus due to atresia of the aqueduct of sylvius and central canal of the medulla
Bi-allelic variations in CRB2, encoding the crumbs cell polarity complex component 2, lead to non-communicating hydrocephalus due to atresia of the aqueduct of sylvius and central canal of the medulla
Congenital hydrocephalus is a common condition caused by the accumulation of cerebrospinal fluid in the ventricular system...
Common molecular features of H3K27M DMGs and PFA ependymomas map to hindbrain developmental pathways
Common molecular features of H3K27M DMGs and PFA ependymomas map to hindbrain developmental pathways
Globally decreased histone 3, lysine 27 tri-methylation (H3K27me3) is a hallmark of H3K27-altered diffuse midline gliomas ...
CNS tumor with EP300::BCOR fusion: discussing its prevalence in adult population
CNS tumor with EP300::BCOR fusion: discussing its prevalence in adult population
The Central Nervous System (CNS) tumor with BCOR internal tandem duplication (ITD) has recently been added as a novel embr...
Sporadic Creutzfeldt–Jakob disease infected human cerebral organoids retain the original human brain subtype features following transmission to humanized transgenic mice
Sporadic Creutzfeldt–Jakob disease infected human cerebral organoids retain the original human brain subtype features following transmission to humanized transgenic mice
Human cerebral organoids (COs) are three-dimensional self-organizing cultures of cerebral brain tissue differentiated from...
Asymmetric dysregulation of glutamate dynamics across the synaptic cleft in a mouse model of Alzheimer’s disease
Asymmetric dysregulation of glutamate dynamics across the synaptic cleft in a mouse model of Alzheimer’s disease
Most research on glutamate spillover focuses on the deleterious consequences of postsynaptic glutamate receptor overactiva...
Identification and gene expression profiling of human gonadotrophic pituitary adenoma stem cells
Identification and gene expression profiling of human gonadotrophic pituitary adenoma stem cells
Gonadotrophic pituitary adenoma is a major subtype of pituitary adenoma in the sellar region, but it is rarely involved in...
Mesenchymal non-meningothelial tumors of the central nervous system: a literature review and diagnostic update of novelties and emerging entities
Mesenchymal non-meningothelial tumors of the central nervous system: a literature review and diagnostic update of novelties and emerging entities
The fifth edition of the World Health Organization Classification of Tumors of the Central Nervous System (CNS) now includ...
Longitudinal DNA methylation analysis of adult-type IDH-mutant gliomas
Longitudinal DNA methylation analysis of adult-type IDH-mutant gliomas
Diffuse gliomas are the most prevalent malignant primary brain tumors in adults and remain incurable despite standard ther...
Lack of a protective effect of the Tmem106b “protective SNP” in the Grn knockout mouse model for frontotemporal lobar degeneration
Lack of a protective effect of the Tmem106b “protective SNP” in the Grn knockout mouse model for frontotemporal lobar degeneration
Genetic variants in TMEM106B are a common risk factor for frontotemporal lobar degeneration and the most important modifie...
Molecular signatures of inherited and acquired sporadic late onset nemaline myopathies
Molecular signatures of inherited and acquired sporadic late onset nemaline myopathies
Acquired sporadic late onset nemaline myopathy (SLONM) and inherited nemaline myopathy (iNM) both feature accumulation of ...
Parkin coregulates glutathione metabolism in adult mammalian brain
Parkin coregulates glutathione metabolism in adult mammalian brain
We recently discovered that the expression of PRKN, a young-onset Parkinson disease-linked gene, confers redox homeostasis...
NAD salvage pathway machinery expression in normal and glaucomatous retina and optic nerve
NAD salvage pathway machinery expression in normal and glaucomatous retina and optic nerve
Glaucoma is the leading cause of irreversible blindness and is a major health and economic burden. Current treatments do n...
Cerebellar granule neurons induce Cyclin D1 before the onset of motor symptoms in Huntington’s disease mice
Cerebellar granule neurons induce Cyclin D1 before the onset of motor symptoms in Huntington’s disease mice
Although Huntington’s disease (HD) is classically defined by the selective vulnerability of striatal projection neur...
Sleep fragmentation affects glymphatic system through the different expression of AQP4 in wild type and 5xFAD mouse models
Sleep fragmentation affects glymphatic system through the different expression of AQP4 in wild type and 5xFAD mouse models
Alzheimer’s disease (AD) is characterized by genetic and multifactorial risk factors. Many studies correlate AD to s...
Minimal expression of dysferlin prevents development of dysferlinopathy in dysferlin exon 40a knockout mice
Minimal expression of dysferlin prevents development of dysferlinopathy in dysferlin exon 40a knockout mice
Dysferlin is a Ca2+-activated lipid binding protein implicated in muscle membrane repair. Recessive variants in DYSF resul...
Clinico-pathological and epigenetic heterogeneity of diffuse gliomas with FGFR3::TACC3 fusion
Clinico-pathological and epigenetic heterogeneity of diffuse gliomas with FGFR3::TACC3 fusion
Gliomas with FGFR3::TACC3 fusion mainly occur in adults, display pathological features of glioblastomas (GB) and are usual...
CIC reduces xCT/SLC7A11 expression and glutamate release in glioma
CIC reduces xCT/SLC7A11 expression and glutamate release in glioma
Capicua (CIC) is an important downstream molecule of RTK/RAS/MAPK pathway. The regulatory mechanism of CIC underlying tumo...
NF2 and ZFTA evaluation in the diagnostic algorithm of pediatric posterior fossa ependymoma with H3K27ME3 retained expression
NF2 and ZFTA evaluation in the diagnostic algorithm of pediatric posterior fossa ependymoma with H3K27ME3 retained expression
Cavalli FMG, Hübner J-M, Sharma T, Luu B, Sill M, Zapotocky M, Mack SC, Witt H, Lin T, Shih DJH, Ho B, Santi M, Emery L, H...
Mutational signature of extracranial meningioma metastases and their respective primary tumors
Mutational signature of extracranial meningioma metastases and their respective primary tumors
Extracranial metastases of intracranial meningiomas are rare. Little is known about the mutational pattern of these tumors...
Reduced T-cell densities in cranial nerves of patients who died with SARS-CoV-2 infection
Reduced T-cell densities in cranial nerves of patients who died with SARS-CoV-2 infection
Cornblath DR, Griffin DE, Welch D, Griffin JW, McArthur JC (1990) Quantitative analysis of endoneurial T-cells in human su...
AI-based MRI auto-segmentation of brain tumor in rodents, a multicenter study
AI-based MRI auto-segmentation of brain tumor in rodents, a multicenter study
Automatic segmentation of rodent brain tumor on magnetic resonance imaging (MRI) may facilitate biomedical research. The c...
Identifying new biomarkers of aggressive Group 3 and SHH medulloblastoma using 3D hydrogel models, single cell RNA sequencing and 3D OrbiSIMS imaging
Identifying new biomarkers of aggressive Group 3 and SHH medulloblastoma using 3D hydrogel models, single cell RNA sequencing and 3D OrbiSIMS imaging
The most common malignant brain tumour in children, medulloblastoma (MB), is subdivided into four clinically relevant mole...
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