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Sarcomatous transformation of IDH-mutant astrocytoma matching to methylation class oligosarcoma following embolization, a case report
Sarcomatous transformation of IDH-mutant astrocytoma matching to methylation class oligosarcoma following embolization, a case report
The mesenchymal transformations of infiltrating gliomas are uncommon events. This is particularly true of IDH-mutant astro...
pTau pathology in the retina of TAU58 mice: association with ganglion cell degeneration and implications on seeding and propagation of pTau from human brain lysates
pTau pathology in the retina of TAU58 mice: association with ganglion cell degeneration and implications on seeding and propagation of pTau from human brain lysates
The accumulation of abnormal phosphorylated Tau protein (pTau) in neurons of the brain is a pathological hallmark of Alzhe...
BCKDK loss impairs mitochondrial Complex I activity and drives alpha-synuclein aggregation in models of Parkinson’s disease
BCKDK loss impairs mitochondrial Complex I activity and drives alpha-synuclein aggregation in models of Parkinson’s disease
Mitochondrial dysfunction and α-synuclein (αSyn) aggregation are key contributors to Parkinson’s Disease (...
BDNF augmentation reverses cranial radiation therapy-induced cognitive decline and neurodegenerative consequences
BDNF augmentation reverses cranial radiation therapy-induced cognitive decline and neurodegenerative consequences
Cranial radiation therapy (RT) for brain cancers is often associated with the development of radiation-induced cognitive d...
The neuropathological basis of elevated serum neurofilament light following experimental concussion
The neuropathological basis of elevated serum neurofilament light following experimental concussion
Mild traumatic brain injury (mTBI) or concussion is a substantial health problem globally, with up to 15% of patients expe...
CK1δ/ε-mediated TDP-43 phosphorylation contributes to early motor neuron disease toxicity in amyotrophic lateral sclerosis
CK1δ/ε-mediated TDP-43 phosphorylation contributes to early motor neuron disease toxicity in amyotrophic lateral sclerosis
Hyperphosphorylated TDP-43 aggregates in the cytoplasm of motor neurons is a neuropathological signature of amyotrophic la...
The X-linked intellectual disability gene CUL4B is critical for memory and synaptic function
The X-linked intellectual disability gene CUL4B is critical for memory and synaptic function
Cullin 4B (CUL4B) is the scaffold protein in the CUL4B-RING E3 ubiquitin ligase (CRL4B) complex. Loss-of-function mutation...
Retinal cytoarchitecture is preserved in an organotypic perfused human and porcine eye model
Retinal cytoarchitecture is preserved in an organotypic perfused human and porcine eye model
Pathobiology of the intact human retina has been challenging to study due to its relative inaccessibility and limited samp...
Spatial transcriptomics in focal cortical dysplasia type IIb
Spatial transcriptomics in focal cortical dysplasia type IIb
Focal cortical dysplasia (FCD) type IIb (FCD IIb) is an epileptogenic malformation of the neocortex that is characterized ...
ALS-linked mutant TDP-43 in oligodendrocytes induces oligodendrocyte damage and exacerbates motor dysfunction in mice
ALS-linked mutant TDP-43 in oligodendrocytes induces oligodendrocyte damage and exacerbates motor dysfunction in mice
Nuclear clearance and cytoplasmic aggregation of TAR DNA-binding protein of 43 kDa (TDP-43) are pathological hall...
Towards integrating imaging and immunology in glioblastoma: mapping blood immune system metrics to tumor magnetic resonance image data
Towards integrating imaging and immunology in glioblastoma: mapping blood immune system metrics to tumor magnetic resonance image data
Glioblastoma is the most frequent and aggressive brain cancer. It is a highly immunology-driven disease as up to a third o...
Down syndrome frontal cortex layer III and layer V pyramidal neurons exhibit lamina specific degeneration in aged individuals
Down syndrome frontal cortex layer III and layer V pyramidal neurons exhibit lamina specific degeneration in aged individuals
Selective vulnerability of neuronal populations occurs in both Down syndrome (DS) and Alzheimer’s disease (AD), resu...
An immune scoring system predicts prognosis and immune characteristics in lung adenocarcinoma brain metastases by RNA sequencing
An immune scoring system predicts prognosis and immune characteristics in lung adenocarcinoma brain metastases by RNA sequencing
Previous studies have reported that the tumor immune microenvironment (TIME) was associated with the prognosis of lung can...
Homozygous CDKN2A/B deletions in low- and high-grade glioma: a meta-analysis of individual patient data and predictive values of p16 immunohistochemistry testing
Homozygous CDKN2A/B deletions in low- and high-grade glioma: a meta-analysis of individual patient data and predictive values of p16 immunohistochemistry testing
CDKN2A/B deletions are prognostically relevant in low- and high-grade gliomas. Data on this is derived from heterogeneous ...
Inhibition of RtTg neurons reverses methamphetamine-induced attention deficits
Inhibition of RtTg neurons reverses methamphetamine-induced attention deficits
Chronic methamphetamine (METH) use, a prevalent psychostimulant, is known to impair attention, yet the cellular mechanisms...
Diffuse pediatric high-grade glioma of methylation-based RTK2A and RTK2B subclasses present distinct radiological and histomolecular features including Gliomatosis cerebri phenotype
Diffuse pediatric high-grade glioma of methylation-based RTK2A and RTK2B subclasses present distinct radiological and histomolecular features including Gliomatosis cerebri phenotype
Diffuse pediatric-type high-grade gliomas (pedHGG), H3- and IDH-wildtype, encompass three main DNA-methylation-based subty...
High detection rate of circulating-tumor DNA from cerebrospinal fluid of children with central nervous system germ cell tumors
High detection rate of circulating-tumor DNA from cerebrospinal fluid of children with central nervous system germ cell tumors
Central nervous system germ cell tumors (CNS-GCT) are malignant neoplasms that arise predominantly during adolescence and ...
Detection of diagnostic somatic copy number alterations from cerebrospinal fluid cell-free DNA in brain tumor patients
Detection of diagnostic somatic copy number alterations from cerebrospinal fluid cell-free DNA in brain tumor patients
The gold standard for precise diagnostic classification of brain tumors requires tissue sampling, which carries relevant p...
A primary intracranial neuroepithelial neoplasm with novel TCF3::BEND2 fusion: a case report
A primary intracranial neuroepithelial neoplasm with novel TCF3::BEND2 fusion: a case report
Astroblastoma, MN1-altered, is a rare circumscribed glial neoplasm that is composed of round, cuboidal, orcolumnar cells w...
Host genetics and gut microbiota influence lipid metabolism and inflammation: potential implications for ALS pathophysiology in SOD1G93A mice
Host genetics and gut microbiota influence lipid metabolism and inflammation: potential implications for ALS pathophysiology in SOD1G93A mice
Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disorder characterized by the progressive loss of m...
Correction: Revisiting gliomatosis cerebri in adult-type diffuse gliomas: a comprehensive imaging, genomic and clinical analysis
Correction: Revisiting gliomatosis cerebri in adult-type diffuse gliomas: a comprehensive imaging, genomic and clinical analysis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Genotype‒phenotype correlation in recessive DNAJB4 myopathy
Genotype‒phenotype correlation in recessive DNAJB4 myopathy
Protein aggregate myopathies can result from pathogenic variants in genes encoding protein chaperones. DNAJB4 is a cochape...
Glioma immune microenvironment composition calculator (GIMiCC): a method of estimating the proportions of eighteen cell types from DNA methylation microarray data
Glioma immune microenvironment composition calculator (GIMiCC): a method of estimating the proportions of eighteen cell types from DNA methylation microarray data
A scalable platform for cell typing in the glioma microenvironment can improve tumor subtyping and immune landscape detect...
NF1 expression profiling in IDH-wildtype glioblastoma: genomic associations and survival outcomes
NF1 expression profiling in IDH-wildtype glioblastoma: genomic associations and survival outcomes
NF1 inactivation is associated with sensitivity to MEK inhibitor targeted therapy in low-grade and some high-grade gliomas...
Dual phenotypes in recurrent astrocytoma, IDH-mutant; coexistence of IDH-mutant and IDH-wildtype components: a case report with genetic and epigenetic analysis
Dual phenotypes in recurrent astrocytoma, IDH-mutant; coexistence of IDH-mutant and IDH-wildtype components: a case report with genetic and epigenetic analysis
Mutations in the isocitrate dehydrogenase (IDH) gene are recognized as the key drivers in the oncogenesis of astrocytoma a...
Acquisition of neurodegenerative features in isogenic OPTN(E50K) human stem cell-derived retinal ganglion cells associated with autophagy disruption and mTORC1 signaling reduction
Acquisition of neurodegenerative features in isogenic OPTN(E50K) human stem cell-derived retinal ganglion cells associated with autophagy disruption and mTORC1 signaling reduction
The ability to derive retinal ganglion cells (RGCs) from human pluripotent stem cells (hPSCs) has led to numerous advances...
Development and characterization of novel anti-acetylated tau monoclonal antibodies to probe pathogenic tau species in Alzheimer’s disease
Development and characterization of novel anti-acetylated tau monoclonal antibodies to probe pathogenic tau species in Alzheimer’s disease
Tauopathies, including Alzheimer’s disease (AD), are a class of neurodegenerative diseases characterized by the pres...
Metabolic remodeling in glioblastoma: a longitudinal multi-omics study
Metabolic remodeling in glioblastoma: a longitudinal multi-omics study
Monitoring tumor evolution and predicting survival using non-invasive liquid biopsy is an unmet need for glioblastoma pati...
A pathogenic mutation in the ALS/FTD gene VCP induces mitochondrial hypermetabolism by modulating the permeability transition pore
A pathogenic mutation in the ALS/FTD gene VCP induces mitochondrial hypermetabolism by modulating the permeability transition pore
Valosin-containing protein (VCP) is a ubiquitously expressed type II AAA+ ATPase protein, implicated in both amyotrophic l...
Crucial role of Aquaporin-4 extended isoform in brain water Homeostasis and Amyloid-β clearance: implications for Edema and neurodegenerative diseases
Crucial role of Aquaporin-4 extended isoform in brain water Homeostasis and Amyloid-β clearance: implications for Edema and neurodegenerative diseases
The water channel aquaporin-4 (AQP4) is crucial for water balance in the mammalian brain. AQP4 has two main canonical isof...
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