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Alpha-synuclein-induced stress sensitivity renders the Parkinson’s disease brain susceptible to neurodegeneration
Alpha-synuclein-induced stress sensitivity renders the Parkinson’s disease brain susceptible to neurodegeneration
A link between chronic stress and Parkinson’s disease (PD) pathogenesis is emerging. Ample evidence demonstrates tha...
Cleaved TMEM106B forms amyloid aggregates in central and peripheral nervous systems
Cleaved TMEM106B forms amyloid aggregates in central and peripheral nervous systems
Filaments made of residues 120-254 of transmembrane protein 106B (TMEM106B) form in an age-dependent manner and can be ext...
Cryo-EM structures reveal tau filaments from Down syndrome adopt Alzheimer’s disease fold
Cryo-EM structures reveal tau filaments from Down syndrome adopt Alzheimer’s disease fold
Down syndrome (DS) is a common genetic condition caused by trisomy of chromosome 21. Among their complex clinical features...
A microdeletion event at 19q13.43 in IDH-mutant astrocytomas is strongly correlated with MYC overexpression
A microdeletion event at 19q13.43 in IDH-mutant astrocytomas is strongly correlated with MYC overexpression
MYC dysregulation is pivotal in the onset and progression of IDH-mutant gliomas, mostly driven by copy-number alterations,...
Comprehensive multiomics analysis reveals distinct differences between pediatric choroid plexus papilloma and carcinoma
Comprehensive multiomics analysis reveals distinct differences between pediatric choroid plexus papilloma and carcinoma
Choroid plexus tumors (CPTs) are intraventricular tumors derived from the choroid plexus epithelium and occur frequently i...
Torpor induces reversible tau hyperphosphorylation and accumulation in mice expressing human tau
Torpor induces reversible tau hyperphosphorylation and accumulation in mice expressing human tau
Tau protein hyperphosphorylation and aggregation are key pathological events in neurodegenerative tauopathies such as Alzh...
Alpha-synuclein aggregates are phosphatase resistant
Alpha-synuclein aggregates are phosphatase resistant
Alpha-synuclein (αsyn) is an intrinsically disordered protein that aggregates in the brain in several neurodegenerati...
Biomarker evidence of early vision and rod energy-linked pathophysiology benefits from very low dose DMSO in 5xFAD mice
Biomarker evidence of early vision and rod energy-linked pathophysiology benefits from very low dose DMSO in 5xFAD mice
Here, we test whether early visual and OCT rod energy-linked biomarkers indicating pathophysiology in nicotinamide nucleot...
Human post-mortem organotypic brain slice cultures: a tool to study pathomechanisms and test therapies
Human post-mortem organotypic brain slice cultures: a tool to study pathomechanisms and test therapies
Human brain experimental models recapitulating age- and disease-related characteristics are lacking. There is urgent need ...
Intravitreal MPTP drives retinal ganglion cell loss with oral nicotinamide treatment providing robust neuroprotection
Intravitreal MPTP drives retinal ganglion cell loss with oral nicotinamide treatment providing robust neuroprotection
Neurodegenerative diseases have common underlying pathological mechanisms including progressive neuronal dysfunction, axon...
Single-cell analysis of a progressive Rosai–Dorfman disease affecting the cerebral parenchyma: a case report
Single-cell analysis of a progressive Rosai–Dorfman disease affecting the cerebral parenchyma: a case report
Neurologic Rosai–Dorfman disease (RDD) is a rare type of non-Langerhans cell histiocytosis that affects the central ...
Hyperoside mitigates photoreceptor degeneration in part by targeting cGAS and suppressing DNA-induced microglial activation
Hyperoside mitigates photoreceptor degeneration in part by targeting cGAS and suppressing DNA-induced microglial activation
Activated microglia play an important role in driving photoreceptor degeneration-associated neuroinflammation in the retin...
Clinical implications of DNA methylation-based integrated classification of histologically defined grade 2 meningiomas
Clinical implications of DNA methylation-based integrated classification of histologically defined grade 2 meningiomas
The combination of DNA methylation analysis with histopathological and genetic features allows for a more accurate risk st...
Neuroinflammation is associated with Alzheimer’s disease co-pathology in dementia with Lewy bodies
Neuroinflammation is associated with Alzheimer’s disease co-pathology in dementia with Lewy bodies
Neuroinflammation and Alzheimer’s disease (AD) co-pathology may contribute to disease progression and severity in de...