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Recursive seed amplification detects distinct α-synuclein strains in cerebrospinal fluid of patients with Parkinson’s disease
Recursive seed amplification detects distinct α-synuclein strains in cerebrospinal fluid of patients with Parkinson’s disease
Parkinson’s disease (PD) is a heterogeneous neurodegenerative disorder with a wide range of clinical phenotypes. Pat...
A novel case of glial transdifferentiation in renal medullary carcinoma brain metastasis
A novel case of glial transdifferentiation in renal medullary carcinoma brain metastasis
Renal medullary carcinoma is a rare undifferentiated tumor of the kidney associated with sickle cell trait and characteriz...
Distinct subcellular localization of tau and alpha-synuclein in lewy body disease
Distinct subcellular localization of tau and alpha-synuclein in lewy body disease
Lewy bodies and neurofibrillary tangles, composed of α-synuclein (α-syn) and tau, respectively, often are found ...
Unraveling calcium dysregulation and autoimmunity in immune mediated rippling muscle disease
Unraveling calcium dysregulation and autoimmunity in immune mediated rippling muscle disease
Rippling Muscle Disease (RMD) is a rare skeletal myopathy characterized by abnormal muscular excitability manifesting with...
Discontiguous recurrences of IDH-wildtype glioblastoma share a common origin with the initial tumor and are frequently hypermutated
Discontiguous recurrences of IDH-wildtype glioblastoma share a common origin with the initial tumor and are frequently hypermutated
Glioblastoma is the deadliest primary brain tumor, largely due to inevitable recurrence of the disease after treatment. Wh...
Transcriptome analysis of novel B16 melanoma metastatic variants generated by serial intracarotid artery injection
Transcriptome analysis of novel B16 melanoma metastatic variants generated by serial intracarotid artery injection
The incidence of brain metastases (BrM) in patients with metastatic melanoma is reported to be 30–50% and constitute...
Pediatric high-grade gliomas with concomitant RB1 and SETD2 alterations and Li-Fraumeni syndrome
Pediatric high-grade gliomas with concomitant RB1 and SETD2 alterations and Li-Fraumeni syndrome
Guerrini-Rousseau L, Tauziède-Espariat A, Castel D, Rouleau E, Sievers P, Saffroy R, Beccaria K, Blauwblomme T, Hasty L, B...
Personalising glioblastoma medicine: explant organoid applications, challenges and future perspectives
Personalising glioblastoma medicine: explant organoid applications, challenges and future perspectives
Glioblastoma (GBM) is a highly aggressive adult brain cancer, characterised by poor prognosis and a dismal five-year survi...
Multiparametric grading of glaucoma severity by histopathology can enable post-mortem substratification of disease state
Multiparametric grading of glaucoma severity by histopathology can enable post-mortem substratification of disease state
Neurodegeneration in glaucoma patients is clinically identified through longitudinal assessment of structure–functio...
Biglycan-driven risk stratification in ZFTA-RELA fusion supratentorial ependymomas through transcriptome profiling
Biglycan-driven risk stratification in ZFTA-RELA fusion supratentorial ependymomas through transcriptome profiling
Recent genomic studies have allowed the subdivision of intracranial ependymomas into molecularly distinct groups with high...
Gain-of-function ANXA11 mutation cause late-onset ALS with aberrant protein aggregation, neuroinflammation and autophagy impairment
Gain-of-function ANXA11 mutation cause late-onset ALS with aberrant protein aggregation, neuroinflammation and autophagy impairment
Mutations in the ANXA11 gene, encoding an RNA-binding protein, have been implicated in the pathogenesis of amyotrophic lat...
Neuropathology-based approach reveals novel Alzheimer's Disease genes and highlights female-specific pathways and causal links to disrupted lipid metabolism: insights into a vicious cycle
Neuropathology-based approach reveals novel Alzheimer's Disease genes and highlights female-specific pathways and causal links to disrupted lipid metabolism: insights into a vicious cycle
Dementia refers to an umbrella phenotype of many different underlying pathologies with Alzheimer’s disease (AD) bein...
Decoding TDP-43: the molecular chameleon of neurodegenerative diseases
Decoding TDP-43: the molecular chameleon of neurodegenerative diseases
TAR DNA-binding protein 43 (TDP-43) has emerged as a critical player in neurodegenerative disorders, with its dysfunction ...
Tppp3 is a novel molecule for retinal ganglion cell identification and optic nerve regeneration
Tppp3 is a novel molecule for retinal ganglion cell identification and optic nerve regeneration
Mammalian central nervous system (CNS) axons cannot spontaneously regenerate after injury, creating an unmet need to ident...
A robust evaluation of TDP-43, poly GP, cellular pathology and behavior in an AAV-C9ORF72 (G4C2)66 mouse model
A robust evaluation of TDP-43, poly GP, cellular pathology and behavior in an AAV-C9ORF72 (G4C2)66 mouse model
The G4C2 hexanucleotide repeat expansion in C9ORF72 is the major genetic cause of both amyotrophic lateral sclerosis (ALS)...
3-Dimensional morphological characterization of neuroretinal microglia in Alzheimer’s disease via machine learning
3-Dimensional morphological characterization of neuroretinal microglia in Alzheimer’s disease via machine learning
Alzheimer’s Disease (AD) is a debilitating neurodegenerative disease that affects 47.5 million people world...
CHMP2B promotes CHMP7 mediated nuclear pore complex injury in sporadic ALS
CHMP2B promotes CHMP7 mediated nuclear pore complex injury in sporadic ALS
Alterations to the composition and function of neuronal nuclear pore complexes (NPCs) have been documented in multiple neu...
Selective retinoid X receptor agonism promotes functional recovery and myelin repair in experimental autoimmune encephalomyelitis
Selective retinoid X receptor agonism promotes functional recovery and myelin repair in experimental autoimmune encephalomyelitis
Evidence that myelin repair is crucial for functional recovery in multiple sclerosis (MS) led to the identification of bex...
Adequate post-ischemic reperfusion of the mouse brain requires endothelial NFAT5
Adequate post-ischemic reperfusion of the mouse brain requires endothelial NFAT5
Severity and outcome of strokes following cerebral hypoperfusion are significantly influenced by stress responses of the b...
JMJD3 deficiency disturbs dopamine biosynthesis in midbrain and aggravates chronic inflammatory pain
JMJD3 deficiency disturbs dopamine biosynthesis in midbrain and aggravates chronic inflammatory pain
Midbrain dopamine (mDA) neurons participate in a wide range of brain functions through an intricate regulation of DA biosy...
Sarcomatous transformation of IDH-mutant astrocytoma matching to methylation class oligosarcoma following embolization, a case report
Sarcomatous transformation of IDH-mutant astrocytoma matching to methylation class oligosarcoma following embolization, a case report
The mesenchymal transformations of infiltrating gliomas are uncommon events. This is particularly true of IDH-mutant astro...
pTau pathology in the retina of TAU58 mice: association with ganglion cell degeneration and implications on seeding and propagation of pTau from human brain lysates
pTau pathology in the retina of TAU58 mice: association with ganglion cell degeneration and implications on seeding and propagation of pTau from human brain lysates
The accumulation of abnormal phosphorylated Tau protein (pTau) in neurons of the brain is a pathological hallmark of Alzhe...
BCKDK loss impairs mitochondrial Complex I activity and drives alpha-synuclein aggregation in models of Parkinson’s disease
BCKDK loss impairs mitochondrial Complex I activity and drives alpha-synuclein aggregation in models of Parkinson’s disease
Mitochondrial dysfunction and α-synuclein (αSyn) aggregation are key contributors to Parkinson’s Disease (...
BDNF augmentation reverses cranial radiation therapy-induced cognitive decline and neurodegenerative consequences
BDNF augmentation reverses cranial radiation therapy-induced cognitive decline and neurodegenerative consequences
Cranial radiation therapy (RT) for brain cancers is often associated with the development of radiation-induced cognitive d...
The neuropathological basis of elevated serum neurofilament light following experimental concussion
The neuropathological basis of elevated serum neurofilament light following experimental concussion
Mild traumatic brain injury (mTBI) or concussion is a substantial health problem globally, with up to 15% of patients expe...
CK1δ/ε-mediated TDP-43 phosphorylation contributes to early motor neuron disease toxicity in amyotrophic lateral sclerosis
CK1δ/ε-mediated TDP-43 phosphorylation contributes to early motor neuron disease toxicity in amyotrophic lateral sclerosis
Hyperphosphorylated TDP-43 aggregates in the cytoplasm of motor neurons is a neuropathological signature of amyotrophic la...
The X-linked intellectual disability gene CUL4B is critical for memory and synaptic function
The X-linked intellectual disability gene CUL4B is critical for memory and synaptic function
Cullin 4B (CUL4B) is the scaffold protein in the CUL4B-RING E3 ubiquitin ligase (CRL4B) complex. Loss-of-function mutation...
Retinal cytoarchitecture is preserved in an organotypic perfused human and porcine eye model
Retinal cytoarchitecture is preserved in an organotypic perfused human and porcine eye model
Pathobiology of the intact human retina has been challenging to study due to its relative inaccessibility and limited samp...
Spatial transcriptomics in focal cortical dysplasia type IIb
Spatial transcriptomics in focal cortical dysplasia type IIb
Focal cortical dysplasia (FCD) type IIb (FCD IIb) is an epileptogenic malformation of the neocortex that is characterized ...
ALS-linked mutant TDP-43 in oligodendrocytes induces oligodendrocyte damage and exacerbates motor dysfunction in mice
ALS-linked mutant TDP-43 in oligodendrocytes induces oligodendrocyte damage and exacerbates motor dysfunction in mice
Nuclear clearance and cytoplasmic aggregation of TAR DNA-binding protein of 43 kDa (TDP-43) are pathological hall...
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