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Early biomarkers in the presymptomatic phase of cognitive impairment: changes in the endocannabinoidome and serotonergic pathways in Alzheimer's-prone mice after mTBI
Early biomarkers in the presymptomatic phase of cognitive impairment: changes in the endocannabinoidome and serotonergic pathways in Alzheimer's-prone mice after mTBI
Despite extensive studies on the neurobiological correlates of traumatic brain injury (TBI), little is known about its mol...
NTRK-fused central nervous system tumours: clinicopathological and genetic insights and response to TRK inhibitors
NTRK-fused central nervous system tumours: clinicopathological and genetic insights and response to TRK inhibitors
Background Neurotrophic tropomyosin receptor kinase (NTRK) gene fusions are found in 1% of gliomas across children and adu...
Papillary tumor of the pineal region: analysis of DNA methylation profiles and clinical outcomes in 76 cases
Papillary tumor of the pineal region: analysis of DNA methylation profiles and clinical outcomes in 76 cases
Papillary tumor of the pineal region (PTPR) is an uncommon tumor of the pineal region with distinctive histopathologic and...
Diffuse glioneuronal tumor with oligodendroglioma-like features and nuclear clusters (DGONC), new name and new problems: an illustration of one case with atypical morphology and biology
Diffuse glioneuronal tumor with oligodendroglioma-like features and nuclear clusters (DGONC), new name and new problems: an illustration of one case with atypical morphology and biology
A novel histomolecular tumor of the central nervous system (CNS), the “diffuse glioneuronal tumor with oligodendrogl...
Altered brain expression and cerebrospinal fluid levels of TIMP4 in cerebral amyloid angiopathy
Altered brain expression and cerebrospinal fluid levels of TIMP4 in cerebral amyloid angiopathy
Cerebral amyloid angiopathy (CAA) is a highly prevalent and progressive pathology, involving amyloid-β (Aβ) depo...
snRNA-seq of human cutaneous neurofibromas before and after selumetinib treatment implicates role of altered Schwann cell states, inter-cellular signaling, and extracellular matrix in treatment response
snRNA-seq of human cutaneous neurofibromas before and after selumetinib treatment implicates role of altered Schwann cell states, inter-cellular signaling, and extracellular matrix in treatment response
Neurofibromatosis Type 1 (NF1) is caused by loss of function variants in the NF1 gene. Most patients with NF1 develop skin...
A multi-institutional series of a novel, recurrent TRIM24::MET fusion-driven infant-type hemispheric glioma reveals significant clinico-pathological heterogeneity
A multi-institutional series of a novel, recurrent TRIM24::MET fusion-driven infant-type hemispheric glioma reveals significant clinico-pathological heterogeneity
Within the past decade, incremental integration of molecular characteristics into the classification of central nervous sy...
Alpha-synuclein-induced stress sensitivity renders the Parkinson’s disease brain susceptible to neurodegeneration
Alpha-synuclein-induced stress sensitivity renders the Parkinson’s disease brain susceptible to neurodegeneration
A link between chronic stress and Parkinson’s disease (PD) pathogenesis is emerging. Ample evidence demonstrates tha...
Neurofibrillary tangle-predominant dementia followed by amyloid β pathology: a clinico-radio-pathological case providing insights into current disease-modifying therapeutic strategy
Neurofibrillary tangle-predominant dementia followed by amyloid β pathology: a clinico-radio-pathological case providing insights into current disease-modifying therapeutic strategy
This work was supported by AMED under Grant Nos. JP22wm0425019 (S.M., Y.S.), JP20dm0107106 (S.M.), JP20dm0107103 (Y.S.), a...
Cleaved TMEM106B forms amyloid aggregates in central and peripheral nervous systems
Cleaved TMEM106B forms amyloid aggregates in central and peripheral nervous systems
Filaments made of residues 120-254 of transmembrane protein 106B (TMEM106B) form in an age-dependent manner and can be ext...
Increase in wasteosomes (corpora amylacea) in frontotemporal lobar degeneration with specific detection of tau, TDP-43 and FUS pathology
Increase in wasteosomes (corpora amylacea) in frontotemporal lobar degeneration with specific detection of tau, TDP-43 and FUS pathology
Wasteosomes (or corpora amylacea) are polyglucosan bodies that appear in the human brain with aging and ...
Cryo-EM structures reveal tau filaments from Down syndrome adopt Alzheimer’s disease fold
Cryo-EM structures reveal tau filaments from Down syndrome adopt Alzheimer’s disease fold
Down syndrome (DS) is a common genetic condition caused by trisomy of chromosome 21. Among their complex clinical features...
A microdeletion event at 19q13.43 in IDH-mutant astrocytomas is strongly correlated with MYC overexpression
A microdeletion event at 19q13.43 in IDH-mutant astrocytomas is strongly correlated with MYC overexpression
MYC dysregulation is pivotal in the onset and progression of IDH-mutant gliomas, mostly driven by copy-number alterations,...
A multiverse of α-synuclein: investigation of prion strain properties with carboxyl-terminal truncation specific antibodies in animal models
A multiverse of α-synuclein: investigation of prion strain properties with carboxyl-terminal truncation specific antibodies in animal models
Synucleinopathies are a group of neurodegenerative disorders characterized by the presence of misfolded α-Synuclein (...
Correction: SNCA genetic lowering reveals differential cognitive function of alpha-synuclein dependent on sex
Correction: SNCA genetic lowering reveals differential cognitive function of alpha-synuclein dependent on sex
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Comprehensive multiomics analysis reveals distinct differences between pediatric choroid plexus papilloma and carcinoma
Comprehensive multiomics analysis reveals distinct differences between pediatric choroid plexus papilloma and carcinoma
Choroid plexus tumors (CPTs) are intraventricular tumors derived from the choroid plexus epithelium and occur frequently i...
Tau modulation through AAV9 therapy augments Akt/Erk survival signalling in glaucoma mitigating the retinal degenerative phenotype
Tau modulation through AAV9 therapy augments Akt/Erk survival signalling in glaucoma mitigating the retinal degenerative phenotype
The microtubule-associated protein Tau is a key player in various neurodegenerative conditions, including Alzheimer's ...
Mitochondrial alterations in fibroblasts from sporadic Alzheimer's disease (AD) patients correlate with AD-related clinical hallmarks
Mitochondrial alterations in fibroblasts from sporadic Alzheimer's disease (AD) patients correlate with AD-related clinical hallmarks
Mitochondrial dysfunctions are key features of Alzheimer’s disease (AD). The occurrence of these disturbances in the...
Torpor induces reversible tau hyperphosphorylation and accumulation in mice expressing human tau
Torpor induces reversible tau hyperphosphorylation and accumulation in mice expressing human tau
Tau protein hyperphosphorylation and aggregation are key pathological events in neurodegenerative tauopathies such as Alzh...
Disruption of the mitochondrial network in a mouse model of Huntington's disease visualized by in-tissue multiscale 3D electron microscopy
Disruption of the mitochondrial network in a mouse model of Huntington's disease visualized by in-tissue multiscale 3D electron microscopy
Huntington’s disease (HD) is an inherited neurodegenerative disorder caused by an expanded CAG repeat in the coding ...
Alpha-synuclein aggregates are phosphatase resistant
Alpha-synuclein aggregates are phosphatase resistant
Alpha-synuclein (αsyn) is an intrinsically disordered protein that aggregates in the brain in several neurodegenerati...
Biomarker evidence of early vision and rod energy-linked pathophysiology benefits from very low dose DMSO in 5xFAD mice
Biomarker evidence of early vision and rod energy-linked pathophysiology benefits from very low dose DMSO in 5xFAD mice
Here, we test whether early visual and OCT rod energy-linked biomarkers indicating pathophysiology in nicotinamide nucleot...
Human post-mortem organotypic brain slice cultures: a tool to study pathomechanisms and test therapies
Human post-mortem organotypic brain slice cultures: a tool to study pathomechanisms and test therapies
Human brain experimental models recapitulating age- and disease-related characteristics are lacking. There is urgent need ...
Axonal autophagic vesicle transport in the rat optic nerve in vivo under normal conditions and during acute axonal degeneration
Axonal autophagic vesicle transport in the rat optic nerve in vivo under normal conditions and during acute axonal degeneration
Neurons pose a particular challenge to degradative processes like autophagy due to their long and thin processes. Autophag...
The neuropathological landscape of small vessel disease and Lewy pathology in a cohort of Hispanic and non-Hispanic White decedents with Alzheimer disease
The neuropathological landscape of small vessel disease and Lewy pathology in a cohort of Hispanic and non-Hispanic White decedents with Alzheimer disease
Cerebrovascular and α-synuclein pathologies are frequently observed alongside Alzheimer disease (AD). The heterogenei...
Aberrant myonuclear domains and impaired myofiber contractility despite marked hypertrophy in MYMK-related, Carey-Fineman-Ziter Syndrome
Aberrant myonuclear domains and impaired myofiber contractility despite marked hypertrophy in MYMK-related, Carey-Fineman-Ziter Syndrome
Carey Fineman Ziter Syndrome (CFZS) is a rare autosomal recessive disease caused by mutations in the MYMK locus which enco...
Intravitreal MPTP drives retinal ganglion cell loss with oral nicotinamide treatment providing robust neuroprotection
Intravitreal MPTP drives retinal ganglion cell loss with oral nicotinamide treatment providing robust neuroprotection
Neurodegenerative diseases have common underlying pathological mechanisms including progressive neuronal dysfunction, axon...
A longer time to relapse is associated with a larger increase in differences between paired primary and recurrent IDH wild-type glioblastomas at both the transcriptomic and genomic levels
A longer time to relapse is associated with a larger increase in differences between paired primary and recurrent IDH wild-type glioblastomas at both the transcriptomic and genomic levels
Glioblastoma (GBM) is the most common malignant brain tumor in adults, which remains incurable and often recurs rapidly af...
Single-cell analysis of a progressive Rosai–Dorfman disease affecting the cerebral parenchyma: a case report
Single-cell analysis of a progressive Rosai–Dorfman disease affecting the cerebral parenchyma: a case report
Neurologic Rosai–Dorfman disease (RDD) is a rare type of non-Langerhans cell histiocytosis that affects the central ...
Hyperoside mitigates photoreceptor degeneration in part by targeting cGAS and suppressing DNA-induced microglial activation
Hyperoside mitigates photoreceptor degeneration in part by targeting cGAS and suppressing DNA-induced microglial activation
Activated microglia play an important role in driving photoreceptor degeneration-associated neuroinflammation in the retin...
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