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Publisher Correction: Exploring the significance of caspase-cleaved tau in tauopathies and as a complementary pathology to phospho-tau in Alzheimer’s disease: implications for biomarker development and therapeutic targeting
Publisher Correction: Exploring the significance of caspase-cleaved tau in tauopathies and as a complementary pathology to phospho-tau in Alzheimer’s disease: implications for biomarker development and therapeutic targeting
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Pediatric-type high-grade gliomas with PDGFRA amplification in adult patients with Li-Fraumeni syndrome: clinical and molecular characterization of three cases
Pediatric-type high-grade gliomas with PDGFRA amplification in adult patients with Li-Fraumeni syndrome: clinical and molecular characterization of three cases
Li-Fraumeni syndrome (LFS) is an autosomal dominant tumor predisposition syndrome caused by heterozygous germline mutation...
Dysregulation of neuroprotective lipoxin pathway in astrocytes in response to cytokines and ocular hypertension
Dysregulation of neuroprotective lipoxin pathway in astrocytes in response to cytokines and ocular hypertension
Glaucoma leads to vision loss due to retinal ganglion cell death. Astrocyte reactivity contributes to neurodegeneration. O...
Ibrutinib disrupts blood-tumor barrier integrity and prolongs survival in rodent glioma model
Ibrutinib disrupts blood-tumor barrier integrity and prolongs survival in rodent glioma model
In malignant glioma, cytotoxic drugs are often inhibited from accessing the tumor site due to the blood-tumor barrier (BTB...
CNS tumors with PLAGL1-fusion: beyond ZFTA and YAP1 in the genetic spectrum of supratentorial ependymomas
CNS tumors with PLAGL1-fusion: beyond ZFTA and YAP1 in the genetic spectrum of supratentorial ependymomas
A novel methylation class, “neuroepithelial tumor, with PLAGL1 fusion” (NET-PLAGL1), has recently been describ...
Letter to the editor on: prophylactic nicotinamide treatment protects from rotenone-induced neurodegeneration by increasing mitochondrial content and volume
Letter to the editor on: prophylactic nicotinamide treatment protects from rotenone-induced neurodegeneration by increasing mitochondrial content and volume
Ethics approval and consent to participate The studies disc...
Disease and brain region specific immune response profiles in neurodegenerative diseases with pure and mixed protein pathologies
Disease and brain region specific immune response profiles in neurodegenerative diseases with pure and mixed protein pathologies
The disease-specific accumulation of pathological proteins has long been the major focus of research in neurodegenerative ...
Shaping the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models
Shaping the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models
The transcellular propagation of the aberrantly modified protein tau along the functional brain network is a key hallmark ...
EpiDiP/NanoDiP: a versatile unsupervised machine learning edge computing platform for epigenomic tumour diagnostics
EpiDiP/NanoDiP: a versatile unsupervised machine learning edge computing platform for epigenomic tumour diagnostics
DNA methylation analysis based on supervised machine learning algorithms with static reference data, allowing diagnostic t...
Tumor associated microglia/macrophages utilize GPNMB to promote tumor growth and alter immune cell infiltration in glioma
Tumor associated microglia/macrophages utilize GPNMB to promote tumor growth and alter immune cell infiltration in glioma
Tumor-associated microglia and blood-derived macrophages (TAMs) play a central role in modulating the immune suppressive m...
MRC1 and LYVE1 expressing macrophages in vascular beds of GNAQ p.R183Q driven capillary malformations in Sturge Weber syndrome
MRC1 and LYVE1 expressing macrophages in vascular beds of GNAQ p.R183Q driven capillary malformations in Sturge Weber syndrome
Sturge-Weber syndrome (SWS), a neurocutaneous disorder, is characterized by capillary malformations (CM) in the skin, brai...
Neuropathological changes associated with aberrant cerebrospinal fluid p-tau181 and Aβ42 in Alzheimer’s disease and other neurodegenerative diseases
Neuropathological changes associated with aberrant cerebrospinal fluid p-tau181 and Aβ42 in Alzheimer’s disease and other neurodegenerative diseases
Recent studies suggest that increased cerebrospinal fluid (CSF) phospho-tau is associated with brain amyloid pathology rat...
Chronic hypoxia remodels the tumor microenvironment to support glioma stem cell growth
Chronic hypoxia remodels the tumor microenvironment to support glioma stem cell growth
Cerebral organoids co-cultured with patient derived glioma stem cells (GLICOs) are an experimentally tractable research to...
Molecular and clinicopathologic characteristics of CNS embryonal tumors with BRD4::LEUTX fusion
Molecular and clinicopathologic characteristics of CNS embryonal tumors with BRD4::LEUTX fusion
Central nervous system (CNS) embryonal tumors are a heterogeneous group of high-grade malignancies, and the increasing cli...
Human adipose tissue-derived stem cell extracellular vesicles attenuate ocular hypertension-induced retinal ganglion cell damage by inhibiting microglia- TLR4/MAPK/NF-κB proinflammatory cascade signaling
Human adipose tissue-derived stem cell extracellular vesicles attenuate ocular hypertension-induced retinal ganglion cell damage by inhibiting microglia- TLR4/MAPK/NF-κB proinflammatory cascade signaling
Microglia-mediated neuroinflammatory responses are recognized as a predominant factor during high intraocular pressure (IO...
β1 integrins play a critical role maintaining vascular integrity in the hypoxic spinal cord, particularly in white matter
β1 integrins play a critical role maintaining vascular integrity in the hypoxic spinal cord, particularly in white matter
Interactions between extracellular matrix (ECM) proteins and β1 integrins play an essential role maintaining vascular...
CNS-associated macrophages contribute to intracerebral aneurysm pathophysiology
CNS-associated macrophages contribute to intracerebral aneurysm pathophysiology
Intracerebral aneurysms (IAs) are pathological dilatations of cerebral arteries whose rupture leads to subarachnoid hemorr...
DNA hypomethylator phenotype reprograms glutamatergic network in receptor tyrosine kinase gene-mutated glioblastoma
DNA hypomethylator phenotype reprograms glutamatergic network in receptor tyrosine kinase gene-mutated glioblastoma
DNA methylation is crucial for chromatin structure and gene expression and its aberrancies, including the global “hy...
Organelle resolved proteomics uncovers PLA2R1 as a novel cell surface marker required for chordoma growth
Organelle resolved proteomics uncovers PLA2R1 as a novel cell surface marker required for chordoma growth
Chordomas are clinically aggressive tumors with a high rate of disease progression despite maximal therapy. Given the limi...
Blood-based CNS regionally and neuronally enriched extracellular vesicles carrying pTau217 for Alzheimer’s disease diagnosis and differential diagnosis
Blood-based CNS regionally and neuronally enriched extracellular vesicles carrying pTau217 for Alzheimer’s disease diagnosis and differential diagnosis
Accurate differential diagnosis among various dementias is crucial for effective treatment of Alzheimer’s disease (A...
Prophylactic nicotinamide treatment protects from rotenone-induced neurodegeneration by increasing mitochondrial content and volume
Prophylactic nicotinamide treatment protects from rotenone-induced neurodegeneration by increasing mitochondrial content and volume
Leber’s hereditary optic neuropathy (LHON) is driven by mtDNA mutations affecting Complex I presenting as progressiv...
Exploring the significance of caspase-cleaved tau in tauopathies and as a complementary pathology to phospho-tau in Alzheimer’s disease: implications for biomarker development and therapeutic targeting
Exploring the significance of caspase-cleaved tau in tauopathies and as a complementary pathology to phospho-tau in Alzheimer’s disease: implications for biomarker development and therapeutic targeting
Tauopathies are neurodegenerative diseases that typically require postmortem examination for a definitive diagnosis. Detec...
Astrocytic accumulation of tau fibrils isolated from Alzheimer’s disease brains induces inflammation, cell-to-cell propagation and neuronal impairment
Astrocytic accumulation of tau fibrils isolated from Alzheimer’s disease brains induces inflammation, cell-to-cell propagation and neuronal impairment
Accumulating evidence highlights the involvement of astrocytes in Alzheimer’s disease (AD) progression. We have prev...
CNS embryonal tumour with concomitant novel BRD4::CTRC1 fusion and BCOR internal tandem duplication – evidence for synergism and non-mutually exclusive alterations in CNS embryonal tumours
CNS embryonal tumour with concomitant novel BRD4::CTRC1 fusion and BCOR internal tandem duplication – evidence for synergism and non-mutually exclusive alterations in CNS embryonal tumours
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Decoding of the surfaceome and endocytome in primary glioblastoma cells identifies potential target antigens in the hypoxic tumor niche
Decoding of the surfaceome and endocytome in primary glioblastoma cells identifies potential target antigens in the hypoxic tumor niche
Immunotherapies with antibody–drug-conjugates (ADC) and CAR-T cells, targeted at tumor surface antigens (surfaceome)...
Stimulating VAPB-PTPIP51 ER-mitochondria tethering corrects FTD/ALS mutant TDP43 linked Ca2+ and synaptic defects
Stimulating VAPB-PTPIP51 ER-mitochondria tethering corrects FTD/ALS mutant TDP43 linked Ca2+ and synaptic defects
Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are clinically linked major neurodegenerative diseas...
Phenotypically concordant distribution of pick bodies in aphasic versus behavioral dementias
Phenotypically concordant distribution of pick bodies in aphasic versus behavioral dementias
Pick’s disease (PiD) is a subtype of the tauopathy form of frontotemporal lobar degeneration (FTLD-tau) characterize...
The cycad genotoxin methylazoxymethanol, linked to Guam ALS/PDC, induces transcriptional mutagenesis
The cycad genotoxin methylazoxymethanol, linked to Guam ALS/PDC, induces transcriptional mutagenesis
Kurland LT, Mulder DW (1954) Epidemiologic investigations of amyotrophic lateral sclerosis I. Preliminary report on geogra...
Hippocampal capillary pericytes in post-stroke and vascular dementias and Alzheimer’s disease and experimental chronic cerebral hypoperfusion
Hippocampal capillary pericytes in post-stroke and vascular dementias and Alzheimer’s disease and experimental chronic cerebral hypoperfusion
Neurovascular unit mural cells called ‘pericytes’ maintain the blood-brain barrier and local cerebral blood fl...
Correction to: Mild traumatic brain injury induces microvascular injury and accelerates Alzheimer-like pathogenesis in mice
Correction to: Mild traumatic brain injury induces microvascular injury and accelerates Alzheimer-like pathogenesis in mice
†Yingxi Wu and Haijian Wu contributed equally.Center for Neurodegeneration and Regeneration, Zilkha Neurogenetic Institute...
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