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Somatic copy number variant load in neurons of healthy controls and Alzheimer’s disease patients
Somatic copy number variant load in neurons of healthy controls and Alzheimer’s disease patients
The possible role of somatic copy number variations (CNVs) in Alzheimer’s disease (AD) aetiology has been controvers...
Methylation differences in Alzheimer’s disease neuropathologic change in the aged human brain
Methylation differences in Alzheimer’s disease neuropathologic change in the aged human brain
Alzheimer’s disease (AD) is the most common cause of dementia with advancing age as its strongest risk factor. AD ne...
CTCF loss induces giant lamellar bodies in Purkinje cell dendrites
CTCF loss induces giant lamellar bodies in Purkinje cell dendrites
CCCTC-binding factor (CTCF) has a key role in higher-order chromatin architecture that is important for establishing and m...
Response to the letter by de Boer et al. (2022)
Response to the letter by de Boer et al. (2022)
Majounie E, Renton AE, Mok K, Dopper EG, Waite A, Rollinson S, Chio A, Restagno G, Nicolaou N, Simon-Sanchez J, van Swiete...
Molecular and spatial heterogeneity of microglia in Rasmussen encephalitis
Molecular and spatial heterogeneity of microglia in Rasmussen encephalitis
Rasmussen encephalitis (RE) is a rare childhood neurological disease characterized by progressive unilateral loss of funct...
Ubiquitin-positive astrogliopathy clinically mimicking Parkinson’s disease
Ubiquitin-positive astrogliopathy clinically mimicking Parkinson’s disease
Several neurodegenerative pathologies can clinically mimic Parkinson’s disease, including neurodegenerative diseases...
Increased unsaturated lipids underlie lipid peroxidation in synucleinopathy brain
Increased unsaturated lipids underlie lipid peroxidation in synucleinopathy brain
Lipid peroxidation is a process of oxidative degradation of cellular lipids that is increasingly recognized as an importan...
Correction to: Integrated genomic analysis reveals actionable targets in pediatric spinal cord low-grade gliomas
Correction to: Integrated genomic analysis reveals actionable targets in pediatric spinal cord low-grade gliomas
Lenka Krskova and Michal Zapotocky authors contributed equally to this studyPrague Brain Tumor Research Group, Second Facu...
A case of primary optic pathway demyelination caused by oncocytic oligodendrogliopathy of unknown origin
A case of primary optic pathway demyelination caused by oncocytic oligodendrogliopathy of unknown origin
We report the case of a 22-year-old woman presenting with an acute onset of dizziness, gait dysbalance and blurred vision....
Stem cell phenotype predicts therapeutic response in glioblastomas with MGMT promoter methylation
Stem cell phenotype predicts therapeutic response in glioblastomas with MGMT promoter methylation
A growing body of evidence supports the presence of a population of cells in glioblastoma (GBM) with a stem cell-like phen...
Single-cell spatial proteomic imaging for human neuropathology
Single-cell spatial proteomic imaging for human neuropathology
Neurodegenerative disorders are characterized by phenotypic changes and hallmark proteopathies. Quantifying these in archi...
Reemergence of pathogenic, autoantibody-producing B cell clones in myasthenia gravis following B cell depletion therapy
Reemergence of pathogenic, autoantibody-producing B cell clones in myasthenia gravis following B cell depletion therapy
Myasthenia gravis (MG) is an autoantibody-mediated autoimmune disorder of the neuromuscular junction. A small subset of pa...
Dual-probe fluorescence spectroscopy for sensitive quantitation of Alzheimer’s amyloid pathology
Dual-probe fluorescence spectroscopy for sensitive quantitation of Alzheimer’s amyloid pathology
Protein misfolding is a prominent pathological hallmark of neurodegenerative disorders, including Alzheimer’s diseas...
The role of plasminogen activator inhibitor-2 in pneumococcal meningitis
The role of plasminogen activator inhibitor-2 in pneumococcal meningitis
Pneumococcal meningitis is associated with dysregulation of the coagulation cascade. Previously, we detected upregulation ...
Artificial intelligence-derived neurofibrillary tangle burden is associated with antemortem cognitive impairment
Artificial intelligence-derived neurofibrillary tangle burden is associated with antemortem cognitive impairment
Tauopathies are a category of neurodegenerative diseases characterized by the presence of abnormal tau protein-containing ...
Plasma proteome profiling identifies changes associated to AD but not to FTD
Plasma proteome profiling identifies changes associated to AD but not to FTD
Frontotemporal dementia (FTD) is caused by frontotemporal lobar degeneration (FTLD), characterized mainly by inclusions of...
Soluble CD146, a biomarker and a target for preventing resistance to anti-angiogenic therapy in glioblastoma
Soluble CD146, a biomarker and a target for preventing resistance to anti-angiogenic therapy in glioblastoma
Glioblastoma multiforme (GBM) is a primary brain tumor with poor prognosis. The U.S. food and drug administration approved...
Reversal of cancer gene expression identifies repurposed drugs for diffuse intrinsic pontine glioma
Reversal of cancer gene expression identifies repurposed drugs for diffuse intrinsic pontine glioma
Diffuse intrinsic pontine glioma (DIPG) is an aggressive incurable brainstem tumor that targets young children. Complete r...
High-resolution transcriptomics informs glial pathology in human temporal lobe epilepsy
High-resolution transcriptomics informs glial pathology in human temporal lobe epilepsy
The pathophysiology of epilepsy underlies a complex network dysfunction between neurons and glia, the molecular cell type-...
Inclusion body myositis and Sjögren’s syndrome: the association works both ways
Inclusion body myositis and Sjögren’s syndrome: the association works both ways
Authors and AffiliationsExploration fonctionnelle musculaire, Service de Physiologie Exploration Fonctionnelle, CRBS Hôpit...
Impact of gulf war toxic exposures after mild traumatic brain injury
Impact of gulf war toxic exposures after mild traumatic brain injury
Chemical and pharmaceutical exposures have been associated with the development of Gulf War Illness (GWI), but how these f...
Integrated genomic analysis reveals actionable targets in pediatric spinal cord low-grade gliomas
Integrated genomic analysis reveals actionable targets in pediatric spinal cord low-grade gliomas
Gliomas are the most common central nervous tumors in children and adolescents. However, spinal cord low-grade gliomas (sL...
Tau seeding in cases of multiple sclerosis
Tau seeding in cases of multiple sclerosis
Relapsing remitting multiple sclerosis (MS) is an inflammatory demyelinating disorder of the central nervous system that i...