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Predicting how many people might receive treatment with new therapies for Alzheimers disease
Predicting how many people might receive treatment with new therapies for Alzheimers disease
One hundred and seventeen years after Alzheimer described the condition that bears his name, the first treatments have bee...
Revisiting the jumping to conclusions bias in functional movement disorders
Revisiting the jumping to conclusions bias in functional movement disorders
Functional movement disorders (FMD) are part of the spectrum of functional neurological disorders (FND), which are common ...
Effects of high-intensity interval training and moderate-intensity continuous training on non-motor symptoms in patients with Parkinsons disease: a randomised pilot trial
Effects of high-intensity interval training and moderate-intensity continuous training on non-motor symptoms in patients with Parkinsons disease: a randomised pilot trial
IntroductionThe benefits of engaging in regular exercise for individuals with Parkinson’s disease (PD) have been widely re...
CIDP trials and tribulations
CIDP trials and tribulations
Two publications in JNNP explore the potential utility of therapies with differing mechanisms of action for the treatment ...
Eligibility for antiamyloid treatment: preparing for disease-modifying therapies for Alzheimers disease
Eligibility for antiamyloid treatment: preparing for disease-modifying therapies for Alzheimers disease
IntroductionAlzheimer’s disease (AD) is the most common cause of dementia. Approximately 944 000 people in the UK live wit...
Patient-perceived progression in multiple system atrophy: natural history of quality of life
Patient-perceived progression in multiple system atrophy: natural history of quality of life
WHAT IS ALREADY KNOWN ON THIS TOPICAlthough health-related quality of life (Hr-QoL) measures could provide crucial informa...
NfL reliability across laboratories, stage-dependent diagnostic performance and matrix comparability in genetic FTD: a large GENFI study
NfL reliability across laboratories, stage-dependent diagnostic performance and matrix comparability in genetic FTD: a large GENFI study
IntroductionGenetic frontotemporal dementias (gFTDs) represent a group of progressive neurodegenerative diseases character...
Clinicoradiological and neuropathological evaluation of primary progressive aphasia
Clinicoradiological and neuropathological evaluation of primary progressive aphasia
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Implications for driving based on the risk of seizures after ischaemic stroke
Implications for driving based on the risk of seizures after ischaemic stroke
Driving a motor vehicle is an important skill set. Its evaluation is relevant to patients who had a stroke. These patients...
Peripheral hearing loss at age 70 predicts brain atrophy and associated cognitive change
Peripheral hearing loss at age 70 predicts brain atrophy and associated cognitive change
IntroductionHearing loss has been proposed as a risk factor for dementia.1–4 However, the mechanisms by which hearing loss...
Efficacy, safety and tolerability of rozanolixizumab in patients with chronic inflammatory demyelinating polyradiculoneuropathy: a randomised, subject-blind, investigator-blind, placebo-controlled, phase 2a trial and open-label extension study
Efficacy, safety and tolerability of rozanolixizumab in patients with chronic inflammatory demyelinating polyradiculoneuropathy: a randomised, subject-blind, investigator-blind, placebo-controlled, phase 2a trial and open-label extension study
IntroductionChronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a rare peripheral nerve disorder character...
Prospective open-label trial with rituximab in patients with chronic inflammatory demyelinating polyradiculoneuropathy not responding to conventional immune therapies
Prospective open-label trial with rituximab in patients with chronic inflammatory demyelinating polyradiculoneuropathy not responding to conventional immune therapies
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Prevalence of autoimmune diseases in functional neurological disorder: influence of psychiatric comorbidities and biological sex
Prevalence of autoimmune diseases in functional neurological disorder: influence of psychiatric comorbidities and biological sex
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T cell activation markers CD38 and HLA-DR indicative of non-seroconversion in anti-CD20-treated patients with multiple sclerosis following SARS-CoV-2 mRNA vaccination
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Pain and functional neurological disorder: a systematic review and meta-analysis
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Validation of the international MOGAD panel proposed criteria: a single-centre US study
Validation of the international MOGAD panel proposed criteria: a single-centre US study
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Antiseizure medication and early pregnancy loss: should we be worried?
Antiseizure medication and early pregnancy loss: should we be worried?
Each year, a large number of pregnancies are exposed to antiseizure medication (ASM) worldwide, when women treated with AS...
Neuropsychological assessment in ALS
Neuropsychological assessment in ALS
Cognitive and behavioural deficits occur in about half of individuals with amyotrophic lateral sclerosis (ALS) and this is...
First-trimester use of antiseizure medications and the risk of miscarriage: a population-based cohort study
First-trimester use of antiseizure medications and the risk of miscarriage: a population-based cohort study
IntroductionAntiseizure medications (ASMs) are used to manage epilepsy, as mood stabilisers for psychiatric conditions suc...
Functional parcellation of the cingulate gyrus by electrical cortical stimulation: a synthetic literature review and future directions
Functional parcellation of the cingulate gyrus by electrical cortical stimulation: a synthetic literature review and future directions
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Disentangling the relationship between social cognition, executive functions and behaviour changes in amyotrophic lateral sclerosis
Disentangling the relationship between social cognition, executive functions and behaviour changes in amyotrophic lateral sclerosis
IntroductionIn the last decades, social cognition (SC) has been investigated in neurodegenerative disorders, including amy...
Primary lateral sclerosis: application and validation of the 2020 consensus diagnostic criteria in an expert opinion-based PLS cohort
Primary lateral sclerosis: application and validation of the 2020 consensus diagnostic criteria in an expert opinion-based PLS cohort
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Effects of motor cortical and peripheral axonal hyperexcitability on survival in amyotrophic lateral sclerosis
Effects of motor cortical and peripheral axonal hyperexcitability on survival in amyotrophic lateral sclerosis
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Prognostic factors of first-onset optic neuritis based on diagnostic criteria and antibody status: a multicentre analysis of 427 eyes
Prognostic factors of first-onset optic neuritis based on diagnostic criteria and antibody status: a multicentre analysis of 427 eyes
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Rates of cortical thinning in Alzheimers disease signature regions associate with vascular burden but not with {beta}-amyloid status in cognitively normal adults at age 70
Rates of cortical thinning in Alzheimers disease signature regions associate with vascular burden but not with {beta}-amyloid status in cognitively normal adults at age 70
IntroductionPrevious MRI studies have identified consistent patterns of decreased cortical thickness in early Alzheimer’s ...
Comparing ocrelizumab to interferon/glatiramer acetate in people with multiple sclerosis over age 60
Comparing ocrelizumab to interferon/glatiramer acetate in people with multiple sclerosis over age 60
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Central vein sign and trigeminal lesions of multiple sclerosis visualised by 7T MRI
Central vein sign and trigeminal lesions of multiple sclerosis visualised by 7T MRI
WHAT IS ALREADY KNOWN ON THIS TOPICThe trigeminal nerve is one of the most involved cranial nerves in multiple sclerosis (...
Does sex influence the natural history of idiopathic adult-onset dystonia?
Does sex influence the natural history of idiopathic adult-onset dystonia?
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Effectiveness of autologous haematopoietic stem cell transplantation versus natalizumab in progressive multiple sclerosis
Effectiveness of autologous haematopoietic stem cell transplantation versus natalizumab in progressive multiple sclerosis
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Reduced pineal volume may be associated with amyloid pathology and not with putative Lewy body pathology
Reduced pineal volume may be associated with amyloid pathology and not with putative Lewy body pathology
IntroductionMelatonin and the pineal glands that secrete it are possibly related to the pathology of Alzheimer’s disease (...
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