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Prospective trial of natalizumab personalised extended interval dosing by therapeutic drug monitoring in relapsing-remitting multiple sclerosis (NEXT-MS)
Prospective trial of natalizumab personalised extended interval dosing by therapeutic drug monitoring in relapsing-remitting multiple sclerosis (NEXT-MS)
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDSPersonalised extended interval dosing based on drug concentrations ...
Exploring the cost-effectiveness of EBV vaccination to prevent multiple sclerosis in an Australian setting
Exploring the cost-effectiveness of EBV vaccination to prevent multiple sclerosis in an Australian setting
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Serum biomarker levels predict disability progression in patients with primary progressive multiple sclerosis
Serum biomarker levels predict disability progression in patients with primary progressive multiple sclerosis
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Predictive value of retinal atrophy for cognitive decline across disease duration in multiple sclerosis
Predictive value of retinal atrophy for cognitive decline across disease duration in multiple sclerosis
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Use, tolerability, benefits and side effects of orthotic devices in Charcot-Marie-Tooth disease
Use, tolerability, benefits and side effects of orthotic devices in Charcot-Marie-Tooth disease
WHAT IS ALREADY KNOWN ON THIS TOPICFoot orthoses are important assistive devices in Charcot-Marie-Tooth disease (CMT) mana...
Evolution of brain MRI lesions in paediatric myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD) and its relevance to disease course
Evolution of brain MRI lesions in paediatric myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD) and its relevance to disease course
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Methodological considerations for observational studies of treatment effectiveness in neurology: a clinicians guide
Methodological considerations for observational studies of treatment effectiveness in neurology: a clinicians guide
Data from cohorts, registries, randomised trials, electronic medical records and administrative claims databases have incr...
Effectiveness of conservative non-pharmacological interventions in people with muscular dystrophies: a systematic review and meta-analysis
Effectiveness of conservative non-pharmacological interventions in people with muscular dystrophies: a systematic review and meta-analysis
MethodsThis systematic review with meta-analysis was conducted using the Preferred Reporting Items for Systematic Reviews ...
Pragmatic computerised perfusion diagnostics for non-convulsive status epilepticus: a prospective observational study
Pragmatic computerised perfusion diagnostics for non-convulsive status epilepticus: a prospective observational study
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Clinical biomarker-based biological ageing and future risk of neurological disorders in the UK Biobank
Clinical biomarker-based biological ageing and future risk of neurological disorders in the UK Biobank
IntroductionAdvancing age is a principal risk factor for many of the most common neurological disorders. Measures of biolo...
Binary reversals: a diagnostic sign in primary progressive aphasia
Binary reversals: a diagnostic sign in primary progressive aphasia
IntroductionDiagnosis of primary progressive aphasia (PPA) is challenging even for expert clinicians.1 Given the current d...
Haemorrhagic myelitis as a manifestation of MOG antibody-associated disease
Haemorrhagic myelitis as a manifestation of MOG antibody-associated disease
We read with interest the recent article ‘MOG antibody-associated encephalitis in adult: clinical phenotypes and outcomes’...
Correction: ICARUS study: prevalence and clinical features of impulse control disorders in Parkinsons disease
Correction: ICARUS study: prevalence and clinical features of impulse control disorders in Parkinsons disease
Antonini A, Barone P, Bonuccelli U, et al. ICARUS study: prevalence and clinical features of impulse control disorders in ...
Dissociative seizures in the emergency department: how to solve the problem of diagnostic confusion leading to iatrogenic harm?
Dissociative seizures in the emergency department: how to solve the problem of diagnostic confusion leading to iatrogenic harm?
Over the last 20 years, there has been a renaissance in the study of functional neurological disorders (FNDs). Alongside a...
Dissociative seizures in the emergency room: room for improvement
Dissociative seizures in the emergency room: room for improvement
IntroductionDissociative seizures, also known as functional or psychogenic non-epileptic seizures, are paroxysms of impair...
GPi-DBS-induced brain metabolic activation in cervical dystonia
GPi-DBS-induced brain metabolic activation in cervical dystonia
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Are patients with GBA-Parkinson disease good candidates for deep brain stimulation? A longitudinal multicentric study on a large Italian cohort
Are patients with GBA-Parkinson disease good candidates for deep brain stimulation? A longitudinal multicentric study on a large Italian cohort
IntroductionParkinson disease (PD) is one of the most common neurodegenerative diseases, with a lifetime prevalence of 3–4...
Seroreactivity against lytic, latent and possible cross-reactive EBV antigens appears on average 10 years before MS induced preclinical neuroaxonal damage
Seroreactivity against lytic, latent and possible cross-reactive EBV antigens appears on average 10 years before MS induced preclinical neuroaxonal damage
IntroductionSeveral pieces of evidence support the involvement of Epstein-Barr virus (EBV) in multiple sclerosis (MS) path...
Temporal course of cognitive and behavioural changes in motor neuron diseases
Temporal course of cognitive and behavioural changes in motor neuron diseases
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDSIn our large observational study, we showed that cognitive impairme...
COVID-19 has no impact on disease activity, progression and cognitive performance in people with multiple sclerosis: a 2-year study
COVID-19 has no impact on disease activity, progression and cognitive performance in people with multiple sclerosis: a 2-year study
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Best practices in phase III clinical trials on DMTs for multiple sclerosis: a systematic analysis and appraisal of published trials
Best practices in phase III clinical trials on DMTs for multiple sclerosis: a systematic analysis and appraisal of published trials
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Alzheimers disease marker phospho-tau181 is not elevated in the first year after moderate-to-severe TBI
Alzheimers disease marker phospho-tau181 is not elevated in the first year after moderate-to-severe TBI
IntroductionTraumatic brain injury (TBI) is common occurrence and an environmental risk factor for dementia. A range of pa...
Do lower limb motor-evoked potentials predict walking outcomes post-stroke?
Do lower limb motor-evoked potentials predict walking outcomes post-stroke?
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The T1-weighted/T2-weighted ratio as a biomarker of anti-NMDA receptor encephalitis
The T1-weighted/T2-weighted ratio as a biomarker of anti-NMDA receptor encephalitis
WHAT IS ALREADY KNOWN ON THIS TOPICConventional MRI shows no abnormalities in the majority of patients with N-methyl-D-asp...
Premorbid brain structure influences risk of amyotrophic lateral sclerosis
Premorbid brain structure influences risk of amyotrophic lateral sclerosis
IntroductionThe clinical manifestations of amyotrophic lateral sclerosis (ALS) occur due to neuronal loss within the corti...
Dementia prevention: the Mendelian randomisation perspective
Dementia prevention: the Mendelian randomisation perspective
IntroductionDespite significant investments in research of Alzheimer’s disease and related dementias over the past decades...
Understanding the pathophysiology of idiopathic intracranial hypertension (IIH): a review of recent developments
Understanding the pathophysiology of idiopathic intracranial hypertension (IIH): a review of recent developments
Idiopathic intracranial hypertension (IIH) is a condition of significant morbidity and rising prevalence. It typically aff...
Genetics, cell biology and a novel mechanism for ALS
Genetics, cell biology and a novel mechanism for ALS
Syeda and colleagues used an elegant combination of genetics, meticulous clinical evaluation and cell biology to demonstra...
Recurrent de-novo gain-of-function mutation in SPTLC2 confirms dysregulated sphingolipid production to cause juvenile amyotrophic lateral sclerosis
Recurrent de-novo gain-of-function mutation in SPTLC2 confirms dysregulated sphingolipid production to cause juvenile amyotrophic lateral sclerosis
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Unilateral focused ultrasound subthalamotomy in early Parkinsons disease: a pilot study
Unilateral focused ultrasound subthalamotomy in early Parkinsons disease: a pilot study
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