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Antiseizure medication and early pregnancy loss: should we be worried?
Antiseizure medication and early pregnancy loss: should we be worried?
Each year, a large number of pregnancies are exposed to antiseizure medication (ASM) worldwide, when women treated with AS...
Neuropsychological assessment in ALS
Neuropsychological assessment in ALS
Cognitive and behavioural deficits occur in about half of individuals with amyotrophic lateral sclerosis (ALS) and this is...
First-trimester use of antiseizure medications and the risk of miscarriage: a population-based cohort study
First-trimester use of antiseizure medications and the risk of miscarriage: a population-based cohort study
IntroductionAntiseizure medications (ASMs) are used to manage epilepsy, as mood stabilisers for psychiatric conditions suc...
Functional parcellation of the cingulate gyrus by electrical cortical stimulation: a synthetic literature review and future directions
Functional parcellation of the cingulate gyrus by electrical cortical stimulation: a synthetic literature review and future directions
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Disentangling the relationship between social cognition, executive functions and behaviour changes in amyotrophic lateral sclerosis
Disentangling the relationship between social cognition, executive functions and behaviour changes in amyotrophic lateral sclerosis
IntroductionIn the last decades, social cognition (SC) has been investigated in neurodegenerative disorders, including amy...
Primary lateral sclerosis: application and validation of the 2020 consensus diagnostic criteria in an expert opinion-based PLS cohort
Primary lateral sclerosis: application and validation of the 2020 consensus diagnostic criteria in an expert opinion-based PLS cohort
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Effects of motor cortical and peripheral axonal hyperexcitability on survival in amyotrophic lateral sclerosis
Effects of motor cortical and peripheral axonal hyperexcitability on survival in amyotrophic lateral sclerosis
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Prognostic factors of first-onset optic neuritis based on diagnostic criteria and antibody status: a multicentre analysis of 427 eyes
Prognostic factors of first-onset optic neuritis based on diagnostic criteria and antibody status: a multicentre analysis of 427 eyes
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Rates of cortical thinning in Alzheimers disease signature regions associate with vascular burden but not with {beta}-amyloid status in cognitively normal adults at age 70
Rates of cortical thinning in Alzheimers disease signature regions associate with vascular burden but not with {beta}-amyloid status in cognitively normal adults at age 70
IntroductionPrevious MRI studies have identified consistent patterns of decreased cortical thickness in early Alzheimer’s ...
Comparing ocrelizumab to interferon/glatiramer acetate in people with multiple sclerosis over age 60
Comparing ocrelizumab to interferon/glatiramer acetate in people with multiple sclerosis over age 60
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Central vein sign and trigeminal lesions of multiple sclerosis visualised by 7T MRI
Central vein sign and trigeminal lesions of multiple sclerosis visualised by 7T MRI
WHAT IS ALREADY KNOWN ON THIS TOPICThe trigeminal nerve is one of the most involved cranial nerves in multiple sclerosis (...
Does sex influence the natural history of idiopathic adult-onset dystonia?
Does sex influence the natural history of idiopathic adult-onset dystonia?
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Effectiveness of autologous haematopoietic stem cell transplantation versus natalizumab in progressive multiple sclerosis
Effectiveness of autologous haematopoietic stem cell transplantation versus natalizumab in progressive multiple sclerosis
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Reduced pineal volume may be associated with amyloid pathology and not with putative Lewy body pathology
Reduced pineal volume may be associated with amyloid pathology and not with putative Lewy body pathology
IntroductionMelatonin and the pineal glands that secrete it are possibly related to the pathology of Alzheimer’s disease (...
Searches for biomarkers using highly sensitive techniques might reveal more about pathogenesis of a disease than provide clinically useful molecular tests
Searches for biomarkers using highly sensitive techniques might reveal more about pathogenesis of a disease than provide clinically useful molecular tests
The era of modern medicine is often linked to the first clinical application of penicillin in 1943.1 How far we have come ...
Therapeutic interventions increasing seizure risk in multiple sclerosis: resolving discordant meta-analyses
Therapeutic interventions increasing seizure risk in multiple sclerosis: resolving discordant meta-analyses
In their JNNP meta-analysis Pozzilli et al concludes that sphingosine-1-phosphate receptor (S1PR) modulators substantially...
Proximity extension assay-based discovery of biomarkers for disease activity in chronic inflammatory demyelinating polyneuropathy
Proximity extension assay-based discovery of biomarkers for disease activity in chronic inflammatory demyelinating polyneuropathy
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Effect of sodium phenylbutyrate and taurursodiol on plasma concentrations of neuroinflammatory biomarkers in amyotrophic lateral sclerosis: results from the CENTAUR trial
Effect of sodium phenylbutyrate and taurursodiol on plasma concentrations of neuroinflammatory biomarkers in amyotrophic lateral sclerosis: results from the CENTAUR trial
IntroductionSafety and efficacy of an oral, fixed-dose sodium phenylbutyrate and taurursodiol combination (PB and TURSO) i...
Excellent response to anti-CD38 therapy with daratumumab in a patient with severe refractory CANOMAD
Excellent response to anti-CD38 therapy with daratumumab in a patient with severe refractory CANOMAD
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Emulating randomised clinical trials in relapsing-remitting multiple sclerosis with non-randomised real-world evidence: an application using data from the MSBase Registry
Emulating randomised clinical trials in relapsing-remitting multiple sclerosis with non-randomised real-world evidence: an application using data from the MSBase Registry
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Incidence and determinants of seizures in multiple sclerosis: a meta-analysis of randomised clinical trials
Incidence and determinants of seizures in multiple sclerosis: a meta-analysis of randomised clinical trials
IntroductionSeizures are more prevalent in individuals with multiple sclerosis (MS) compared with the general population.1...
Stratifying quality of life outcome in subthalamic stimulation for Parkinsons disease
Stratifying quality of life outcome in subthalamic stimulation for Parkinsons disease
IntroductionSubthalamic nucleus deep brain stimulation (STN-DBS) is a safe and effective treatment of advanced Parkinson’s...
Long-term disability progression in aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder: a retrospective analysis of 101 patients
Long-term disability progression in aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder: a retrospective analysis of 101 patients
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Prevalence and burden of pain across the entire spectrum of Huntingtons disease
Prevalence and burden of pain across the entire spectrum of Huntingtons disease
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Flavonoid intake and risk of Parkinsons disease
Flavonoid intake and risk of Parkinsons disease
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Impact of white matter networks on risk for memory decline following resection versus ablation in temporal lobe epilepsy
Impact of white matter networks on risk for memory decline following resection versus ablation in temporal lobe epilepsy
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ON/OFF non-motor evaluation: a new way to evaluate non-motor fluctuations in Parkinsons disease
ON/OFF non-motor evaluation: a new way to evaluate non-motor fluctuations in Parkinsons disease
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The influence of epigenetic biological age on key complications and outcomes in aneurysmal subarachnoid haemorrhage
The influence of epigenetic biological age on key complications and outcomes in aneurysmal subarachnoid haemorrhage
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NICE guideline on ME/CFS: robust advice based on a thorough review of the evidence
NICE guideline on ME/CFS: robust advice based on a thorough review of the evidence
Guidelines produced by the National Institute for Health and Care Excellence (NICE) are developed by independent advisory ...
Genotype-specific spinal cord damage in spinocerebellar ataxias: an ENIGMA-Ataxia study
Genotype-specific spinal cord damage in spinocerebellar ataxias: an ENIGMA-Ataxia study
WHAT IS ALREADY KNOWN ON THIS TOPICSpinal cord degeneration is thought to be a key aspect of many spinocerebellar disorder...
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