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Blood biomarkers: ready for clinical practice?
Blood biomarkers: ready for clinical practice?
Most people would want to know early, if they had Alzheimer’s disease (AD).1 Potential new treatments, such as lecanemab, ...
Plasma phosphorylated tau 181 predicts amyloid status and conversion to dementia stage dependent on renal function
Plasma phosphorylated tau 181 predicts amyloid status and conversion to dementia stage dependent on renal function
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDSIn our large prospective cohort, P-tau181 predicts brain amyloidopa...
Plasma biomarkers for Alzheimers disease: a field-test in a memory clinic
Plasma biomarkers for Alzheimers disease: a field-test in a memory clinic
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDSPlasma biomarkers significantly correlated with traditional biomark...
Elevated plasma p-tau181 levels unrelated to Alzheimers disease pathology in amyotrophic lateral sclerosis
Elevated plasma p-tau181 levels unrelated to Alzheimers disease pathology in amyotrophic lateral sclerosis
IntroductionAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterised by the progressive degenerati...
GSN gene frameshift mutations in Alzheimers disease
GSN gene frameshift mutations in Alzheimers disease
IntroductionAlzheimer’s disease (AD) is a neurodegenerative disease that causes a progressive decline in memory and cognit...
Cognitive performance is associated with glomerular filtration rate in patients with chronic kidney disease: results from the CKD-REIN cohort
Cognitive performance is associated with glomerular filtration rate in patients with chronic kidney disease: results from the CKD-REIN cohort
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Structural and functional changes in the retina in Parkinsons disease
Structural and functional changes in the retina in Parkinsons disease
Parkinson’s disease is caused by degeneration of dopaminergic neurons, originating in the substantia nigra pars compacta a...
Effectiveness of an outpatient rehabilitation programme in patients with neuralgic amyotrophy and scapular dyskinesia: a randomised controlled trial
Effectiveness of an outpatient rehabilitation programme in patients with neuralgic amyotrophy and scapular dyskinesia: a randomised controlled trial
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Effectiveness of early cycles of fast-acting treatment in generalised myasthenia gravis
Effectiveness of early cycles of fast-acting treatment in generalised myasthenia gravis
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Ocrelizumab concentration and antidrug antibodies are associated with B-cell count in multiple sclerosis
Ocrelizumab concentration and antidrug antibodies are associated with B-cell count in multiple sclerosis
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Decrease of natalizumab drug levels after switching from intravenous to subcutaneous administration in patients with multiple sclerosis
Decrease of natalizumab drug levels after switching from intravenous to subcutaneous administration in patients with multiple sclerosis
IntroductionNatalizumab, a monoclonal antibody used in relapsing remitting multiple sclerosis (MS), reduces inflammation w...
Humoral and cellular responses to SARS-CoV-2 vaccination in patients with autoantibody-mediated neuroimmunology
Humoral and cellular responses to SARS-CoV-2 vaccination in patients with autoantibody-mediated neuroimmunology
IntroductionCOVID-19 caused by SARS-CoV-2 is still prevalent worldwide. In Japan, two types of mRNA vaccines, BNT162b2 and...
Prevalence, incidence and clinical features of neuromyelitis optica spectrum disorders in northern Japan
Prevalence, incidence and clinical features of neuromyelitis optica spectrum disorders in northern Japan
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disorder of the central nervous system that p...
Evidence of a third branch in the uncinate fasciculus and possible implications
Evidence of a third branch in the uncinate fasciculus and possible implications
The uncinate fasciculus (UF) is a ventral, anterior, associative C-shaped white matter bundle that connects the temporo-am...
Insufficient sleep during adolescence and risk of multiple sclerosis: results from a Swedish case-control study
Insufficient sleep during adolescence and risk of multiple sclerosis: results from a Swedish case-control study
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDSInsufficient sleep and low sleep quality during adolescence dose-de...
Spasticity treatment patterns among people with multiple sclerosis: a Swedish cohort study
Spasticity treatment patterns among people with multiple sclerosis: a Swedish cohort study
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDSThis is the first large, population-based assessment of spasticity ...
Timing of physical activity across adulthood on later-life cognition: 30 years follow-up in the 1946 British birth cohort
Timing of physical activity across adulthood on later-life cognition: 30 years follow-up in the 1946 British birth cohort
WHAT IS ALREADY KNOWN ON THIS TOPICPhysical activity is one proposed modifiable risk factor, modestly associated with lowe...
Neuropsychiatric symptoms in genetic frontotemporal dementia: developing a new module for Clinical Rating Scales
Neuropsychiatric symptoms in genetic frontotemporal dementia: developing a new module for Clinical Rating Scales
IntroductionFrontotemporal dementia (FTD) is a heterogeneous neurodegenerative disorder that commonly presents with either...
Deep learning-based personalised outcome prediction after acute ischaemic stroke
Deep learning-based personalised outcome prediction after acute ischaemic stroke
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Psychiatric symptoms in multiple sclerosis: a biological perspective on synaptic and network dysfunction
Psychiatric symptoms in multiple sclerosis: a biological perspective on synaptic and network dysfunction
Psychiatric symptoms frequently occur in multiple sclerosis (MS), presenting with a complex phenomenology that encompasses...
Structural and functional correlates of the response to deep brain stimulation at ventral capsule/ventral striatum region for treatment-resistant depression
Structural and functional correlates of the response to deep brain stimulation at ventral capsule/ventral striatum region for treatment-resistant depression
WHAT IS ALREADY KNOWN ON THIS TOPICDeep brain stimulation (DBS) in ventral capsule/ventral striatum (VC/VS) showed potenti...
A roadmap to ALS prevention: strategies and priorities
A roadmap to ALS prevention: strategies and priorities
IntroductionAmyotrophic lateral sclerosis (ALS) is often considered a relatively rare disease, but risk estimates suggest ...
Adult-onset epilepsy and risk of traumatic brain injury: a nationwide cohort study
Adult-onset epilepsy and risk of traumatic brain injury: a nationwide cohort study
IntroductionTraumatic brain injury (TBI) is a leading cause of lost work years, disability and mortality in all age groups...
Ceroid lipofuscinosis type 5: novel pathogenic variants and unexpected phenotypic findings
Ceroid lipofuscinosis type 5: novel pathogenic variants and unexpected phenotypic findings
The neuronal ceroid lipofuscinoses (NCLs) are genetic disorders characterised by accumulation of autofluorescent material ...
First presentation with neuropsychiatric symptoms in autosomal dominant Alzheimers disease: the Dominantly Inherited Alzheimers Network Study
First presentation with neuropsychiatric symptoms in autosomal dominant Alzheimers disease: the Dominantly Inherited Alzheimers Network Study
IntroductionBehavioural changes and neuropsychiatric symptoms (NPS) commonly occur in Alzheimer’s disease (AD) but may not...
The prospects for poststroke neural repair with vagal nerve stimulation
The prospects for poststroke neural repair with vagal nerve stimulation
Stroke is one of the major global healthcare problems with over 100 million stroke survivors worldwide.1 It is no longer s...
Vagus nerve stimulation paired with rehabilitation for motor function, mental health and activities of daily living after stroke: a systematic review and meta-analysis
Vagus nerve stimulation paired with rehabilitation for motor function, mental health and activities of daily living after stroke: a systematic review and meta-analysis
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Cerebroprotection in the endovascular era: an update
Cerebroprotection in the endovascular era: an update
In the last several decades, ischaemic stroke treatment has been improved thanks to better patient selection with imaging ...
Contemporary study of multiple sclerosis disability in South East Wales
Contemporary study of multiple sclerosis disability in South East Wales
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SARS-CoV-2 omicron breakthrough infections in patients with multiple sclerosis
SARS-CoV-2 omicron breakthrough infections in patients with multiple sclerosis
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