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Knockdown of sexually differentiated vasopressin expression in the bed nucleus of the stria terminalis reduces social and sexual behaviour in male, but not female, mice
Knockdown of sexually differentiated vasopressin expression in the bed nucleus of the stria terminalis reduces social and sexual behaviour in male, but not female, mice
Abstract The neuropeptide arginine-vasopressin (AVP) has long been implicated in the regulation of social behaviour and co...
Review of human genetic and clinical studies directly relevant to GnRH signalling
Review of human genetic and clinical studies directly relevant to GnRH signalling
Abstract GnRH is the pivotal hormone in controlling the hypothalamic-pituitary gonadal (HPG) axis in humans and other mamm...
Mathematical models in GnRH research
Mathematical models in GnRH research
Abstract Mathematical modelling is an indispensable tool in modern biosciences, enabling quantitative analysis and integra...
Synthetic neuroactive steroids as new sedatives and anesthetics: back to the future
Synthetic neuroactive steroids as new sedatives and anesthetics: back to the future
Abstract Since the 1990s, there has been waning interest in researching general anesthetics (anesthetics). Although curren...
Cannabinoid and vanilloid pathways mediate opposing forms of synaptic plasticity in corticotropin‐releasing hormone neurons
Cannabinoid and vanilloid pathways mediate opposing forms of synaptic plasticity in corticotropin‐releasing hormone neurons
Abstract Activity-dependent release of retrograde signaling molecules form micro-feedback loops to regulate synaptic funct...
Development of the Gonadotropin releasing hormone system
Development of the Gonadotropin releasing hormone system
Abstract This review summarizes the current understanding of the development of the neuroendocrine GnRH system, including ...
A role for deficits in GABAergic neurosteroids and their metabolites with NMDA receptor antagonist activity in the pathophysiology of posttraumatic stress disorder
A role for deficits in GABAergic neurosteroids and their metabolites with NMDA receptor antagonist activity in the pathophysiology of posttraumatic stress disorder
Abstract Trauma-focused psychotherapies show general efficacy in post-traumatic stress disorder (PTSD), although outcomes ...
Knockdown of Sexually Differentiated Vasopressin Expression in the Bed Nucleus of the Stria Terminalis Reduces Social and Sexual Behavior in Male, but Not Female, Mice
Knockdown of Sexually Differentiated Vasopressin Expression in the Bed Nucleus of the Stria Terminalis Reduces Social and Sexual Behavior in Male, but Not Female, Mice
Abstract The neuropeptide arginine-vasopressin (AVP) has long been implicated in the regulation of social behavior and com...
Multiple gonadotropin‐releasing hormone systems in non‐mammalian vertebrates: Ontogeny, anatomy, and physiology
Multiple gonadotropin‐releasing hormone systems in non‐mammalian vertebrates: Ontogeny, anatomy, and physiology
Abstract Three paralogous genes for gonadotropin-releasing hormone (GnRH; gnrh1, gnrh2, and gnrh3) and GnRH receptors exis...
Puberty enables estradiol‐induced progesterone synthesis in female mouse hypothalamic astrocytes
Puberty enables estradiol‐induced progesterone synthesis in female mouse hypothalamic astrocytes
ABSTRACT The development of estrogen positive feedback is a hallmark of female puberty. Both estrogen and progesterone sig...
Review of the Human Genetic and Clinical Studies Directly Relevant to the GnRH Signaling
Review of the Human Genetic and Clinical Studies Directly Relevant to the GnRH Signaling
Abstract GnRH is the pivotal hormone in controlling the hypothalamo-pituitary gonadal (HPG) axis in humans and other mamma...
The roles of kisspeptin and neurokinin B in GnRH pulse generation in humans, and their potential clinical application
The roles of kisspeptin and neurokinin B in GnRH pulse generation in humans, and their potential clinical application
Abstract The delivery of GnRH in a pulsatile mode to the gonadotropes has long been known to be essential for normal repro...
Tanycyte specific ablation of diacylglycerol lipase alpha stimulates the hypothalamic‐pituitary‐thyroid axis by decreasing the endocannabinoid mediated inhibition of TRH release
Tanycyte specific ablation of diacylglycerol lipase alpha stimulates the hypothalamic‐pituitary‐thyroid axis by decreasing the endocannabinoid mediated inhibition of TRH release
Abstract In addition to the hypophysiotropic thyrotropin-releasing hormone (TRH)-synthesizing neurons, a glial cell type, ...
G protein‐coupled receptor interactions and modification of signalling involving the ghrelin receptor, GHSR1a
G protein‐coupled receptor interactions and modification of signalling involving the ghrelin receptor, GHSR1a
Abstract The growth hormone secretagogue receptor 1a (GHSR1a) is intriguing because of its potential as a therapeutic targ...
Tibolone restrains neuroinflammation in mouse experimental autoimmune encephalomyelitis
Tibolone restrains neuroinflammation in mouse experimental autoimmune encephalomyelitis
ABSTRACT Multiple sclerosis (MS) is an immune-mediated and degenerating disease in which myelin sheaths are damaged due to...
Relevant prognostic factors in patients with stage IV small intestine neuroendocrine neoplasms
Relevant prognostic factors in patients with stage IV small intestine neuroendocrine neoplasms
Abstract Background There are only few, but controversial data on the prognostic role of upfront primary tumor resection a...
Breakdown of the blood‐brain barrier: a mediator of increased Alzheimer's risk in patients with metabolic disorders?
Breakdown of the blood‐brain barrier: a mediator of increased Alzheimer's risk in patients with metabolic disorders?
Abstract Metabolic disorders (MDs), including type-1 and 2 diabetes (T2DM) and chronic obesity, are among the faster growi...
Brain functional connectivity in patients with hyperthyroidism after anti‐thyroid treatment
Brain functional connectivity in patients with hyperthyroidism after anti‐thyroid treatment
Abstract Objectives Thyroid disease is known to affect brain metabolism and cognitive function, but the recovery of thyroi...
The electrophysiologic properties of gonadotropin‐releasing hormone neurons
The electrophysiologic properties of gonadotropin‐releasing hormone neurons
Summary For about two decades, recordings of identified gonadotropin-releasing hormone (GnRH) neurons have provided a weal...
Progesterone receptor‐Src kinase signaling pathway mediates neuroprogesterone induction of the luteinizing hormone surge in female rats
Progesterone receptor‐Src kinase signaling pathway mediates neuroprogesterone induction of the luteinizing hormone surge in female rats
ABSTRACT Neural circuits in female rats are exposed to sequential estradiol and progesterone to regulate the release of lu...
Neuroendocrine underpinning of social recognition in males and females
Neuroendocrine underpinning of social recognition in males and females
Abstract Social recognition is an essential skill for the expression of appropriate behaviors towards conspecifics in most...
Cell type specificity of glucocorticoid signaling in the adult mouse hippocampus
Cell type specificity of glucocorticoid signaling in the adult mouse hippocampus
Abstract Glucocorticoid stress hormones are powerful modulators of brain function and can affect mood and cognitive proces...
A half century of fish gonadotropin‐releasing hormones: Breaking paradigms
A half century of fish gonadotropin‐releasing hormones: Breaking paradigms
ABSTRACT The field of fish gonadotropin-releasing hormones (GnRH) is also celebrating its 50th anniversary this year. This...
Gonadotropin‐releasing hormone (GnRH) measurements in pituitary portal blood: a history
Gonadotropin‐releasing hormone (GnRH) measurements in pituitary portal blood: a history
Summary Much about the neuroendocrine control of reproduction is inferred from changes in the episodic release of luteiniz...
Multiple GnRH Systems in Non‐mammalian Vertebrates: Ontogeny, Anatomy, and Physiology
Multiple GnRH Systems in Non‐mammalian Vertebrates: Ontogeny, Anatomy, and Physiology
Abstract Three paralogous genes for GnRH (gnrh1, gnrh2, and gnrh3), and GnRH receptors exist in non-mammalian vertebrates....
Pregnancy and brain architecture – associations with hormones, cognition and affect
Pregnancy and brain architecture – associations with hormones, cognition and affect
Abstract Sex hormones such as estradiol (E2) have long-lasting influence on brain architecture. Recent studies indicate fu...
Duodenal neuroendocrine neoplasms with unexpectedly aggressive behaviour: challenging the “watch and wait” approach
Duodenal neuroendocrine neoplasms with unexpectedly aggressive behaviour: challenging the “watch and wait” approach
Abstract The incidence of duodenal neuroendocrine neoplasms has risen over the past decades due to the wide availability a...
The Effects of Somatostatin Analogues on Glycaemia in the Treatment of Neuroendocrine Tumours
The Effects of Somatostatin Analogues on Glycaemia in the Treatment of Neuroendocrine Tumours
Abstract Long-acting somatostatin analogues (SSA) are the most commonly used drugs in the management of neuroendocrine tum...
Distribution of androgen receptor mRNA in the prepubertal male and female mouse brain
Distribution of androgen receptor mRNA in the prepubertal male and female mouse brain
Abstract Androgens are steroid hormones that play a critical role in brain development and sexual maturation by acting upo...
A Role for Deficits in GABAergic Neurosteroids and their Metabolites with NMDA Receptor Antagonist Activity in the Pathophysiology of PTSD
A Role for Deficits in GABAergic Neurosteroids and their Metabolites with NMDA Receptor Antagonist Activity in the Pathophysiology of PTSD
ABSTRACT Trauma-focused psychotherapies show general efficacy in posttraumatic stress disorder (PTSD), but outcomes vary s...
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