SCI时时刷

search
+
A strategy to load, rethread and read protein sequences through a nanopore
Understanding proteomic diversity at the molecular level is essential for advances in biology and medicine, but sequencing...
Niemann–Pick double win
In one week, the US Food and Drug Administration approved two treatments for Niemann–Pick disease type C (NPC). One agent,...
T cells
Recent patents relating to the manufacture, preparation and use of T cells in treating cancer.
Cellular shuttles put mislocalized proteins in their right place
The misplacement of proteins within a cell can cause various diseases, but no therapeutic intervention can precisely contr...
Bispecific upstages Keytruda
The new bispecific drug ivonescimab has outperformed Merck’s blockbuster PD-1 checkpoint inhibitor Keytruda (pembrolizumab...
From Bench to Podcast: Chloe Fishman
From Bench to Podcast: Chloe Fishman
Join us as Cláudia and Chloe touch bases on the advantages of this tool over existing methods, discuss the relevance of ph...
Pan-KRAS destruction with a single PROTAC
Most small-molecule drugs that target oncogenic Kirsten rat sarcoma virus (KRAS) mutants rely on interactions with variant...
Impact of bariatric surgery on gut microbiota composition in obese patients compared to healthy controls
Impact of bariatric surgery on gut microbiota composition in obese patients compared to healthy controls
Bariatric surgery is vital for sustainable weight loss and metabolic improvement in obese individuals, but its effects on ...
Surveillance of human adenoviruses in water environments: Assessing the suitability of a locally developed quenching of unincorporated amplification signal reporters-loop-mediated isothermal amplification assay
Update your browser to view ScienceDirect. View recommended browsers. Request details: Request ID: 8d2befa61ff76452-...
Validation of an HPLC-CAD method for measuring the lipid content of novel LNP-encapsulated COVID-19 mRNA vaccines
Update your browser to view ScienceDirect. View recommended browsers. Request details: Request ID: 8d2bef98eae89465-...
Construction of bispecific antibodies by specific pairing between the heavy chain and the light chain using removable SpyCatcher/SnoopCatcher units
Construction of bispecific antibodies by specific pairing between the heavy chain and the light chain using removable SpyCatcher/SnoopCatcher units
During the production of bispecific antibodies (bsAbs), nonspecific pairing results in low yields of target bsAb molecules...
Design and application of microfluidics in aptamer SELEX and Aptasensors
Update your browser to view ScienceDirect. View recommended browsers. Request details: Request ID: 8d1fbd7468c515ef-...
Transipedia.org: k-mer-based exploration of large RNA sequencing datasets and application to cancer data
Transipedia.org: k-mer-based exploration of large RNA sequencing datasets and application to cancer data
Indexing techniques relying on k-mers have proven effective in searching for RNA sequences across thousands of RNA-seq lib...
Spatiotemporal modeling reveals high-resolution invasion states in glioblastoma
Spatiotemporal modeling reveals high-resolution invasion states in glioblastoma
Diffuse invasion of glioblastoma cells through normal brain tissue is a key contributor to tumor aggressiveness, resistanc...
Graphasing: phasing diploid genome assembly graphs with single-cell strand sequencing
Graphasing: phasing diploid genome assembly graphs with single-cell strand sequencing
Haplotype information is crucial for biomedical and population genetics research. However, current strategies to produce d...
Drought-responsive dynamics of H3K9ac-marked 3D chromatin interactions are integrated by OsbZIP23-associated super-enhancer-like promoter regions in rice
Drought-responsive dynamics of H3K9ac-marked 3D chromatin interactions are integrated by OsbZIP23-associated super-enhancer-like promoter regions in rice
In response to drought stress (DS), plants undergo complex processes that entail significant transcriptome reprogramming. ...
Improved detection of methylation in ancient DNA
Improved detection of methylation in ancient DNA
Reconstructing premortem DNA methylation levels in ancient DNA has led to breakthrough studies such as the prediction of a...
An antigen discovery pipeline integrates multi-omics data and informs immunotherapy
An antigen discovery pipeline integrates multi-omics data and informs immunotherapy
We developed NeoDisc, a computational antigen discovery pipeline that integrates multi-omics data, including genomics, tra...
Model-directed generation of artificial CRISPR–Cas13a guide RNA sequences improves nucleic acid detection
Model-directed generation of artificial CRISPR–Cas13a guide RNA sequences improves nucleic acid detection
CRISPR guide RNA sequences deriving exactly from natural sequences may not perform optimally in every application. Here we...
A comprehensive proteogenomic pipeline for neoantigen discovery to advance personalized cancer immunotherapy
A comprehensive proteogenomic pipeline for neoantigen discovery to advance personalized cancer immunotherapy
The accurate identification and prioritization of antigenic peptides is crucial for the development of personalized cancer...
A community effort to optimize sequence-based deep learning models of gene regulation
A community effort to optimize sequence-based deep learning models of gene regulation
A systematic evaluation of how model architectures and training strategies impact genomics model performance is needed. To...
Biotransformation of diclofenac by Stenotrophomonas humi strain DIC_5 and toxicological examination of the resulting metabolites
Biotransformation of diclofenac by Stenotrophomonas humi strain DIC_5 and toxicological examination of the resulting metabolites
The widely used non-steroidal anti-inflammatory drug, diclofenac, detected in increasing concentrations in freshwater ecos...
Singapore grouper iridovirus VP12 evades the host antiviral immune response by targeting the cGAS-STING signalling pathway
Singapore grouper iridovirus VP12 evades the host antiviral immune response by targeting the cGAS-STING signalling pathway
The emergence of Singapore grouper iridovirus (SGIV) has caused huge losses to grouper farming. SGIV is a DNA virus and be...
Unveiling six novel CALB-like lipases using genome-centric and patent-driven prospection
Update your browser to view ScienceDirect. View recommended browsers. Request details: Request ID: 8d143dfb686fceb5-...
Enhanced soluble expression and characterization of human N-acetylglucosaminyltransferase IVa in Escherichia coli
Update your browser to view ScienceDirect. View recommended browsers. Request details: Request ID: 8d143dea9f471732-...
Infectivity titers and aggregation states of intracellular and extracellular nervous necrosis virus in cell lines with cytolytic and persistent infections
Update your browser to view ScienceDirect. View recommended browsers. Request details: Request ID: 8d117ccedca19648-...
Enhancing fatty acid and omega-3 production in Schizochytrium sp. using developed safe-harboring expression system
Enhancing fatty acid and omega-3 production in Schizochytrium sp. using developed safe-harboring expression system
Schizochytrium, a group of eukaryotic marine protists, is an oleaginous strain, making it a highly promising candidate for...
Tapping the treasure trove of atypical phages
Update your browser to view ScienceDirect. View recommended browsers. Request details: Request ID: 8d0fb07179342368-...
Comparative transcriptome analysis and identification of candidate bZIP transcription factors involved in anthraquinone biosynthesis in Rheum officinale Baill
Update your browser to view ScienceDirect. View recommended browsers. Request details: Request ID: 8d0e11eed81e6426-...
Integration analysis of transcriptome and metabolome revealed the potential mechanism of spermatogenesis in Tibetan sheep (Ovis aries) at extreme high altitude
Update your browser to view ScienceDirect. View recommended browsers. Request details: Request ID: 8d0e11e84f1196d1-...
阅读更多
format_indent_increase