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Deep dive into a drug pump
Deep dive into a drug pump
Major hurdles remain in understanding the mechanisms of multidrug resistance (MDR) protein efflux. A new study uses deep m...
A sweet feast
A sweet feast
High-mannose N-glycans are common post-translational modifications that occur on many proteins. The mechanism by which the...
Mechanism of high-mannose N-glycan breakdown and metabolism by Bifidobacterium longum
Mechanism of high-mannose N-glycan breakdown and metabolism by Bifidobacterium longum
Bifidobacteria are early colonizers of the human gut and play central roles in human health and metabolism. To thrive in t...
Deep mutational scan of a drug efflux pump reveals its structure–function landscape
Deep mutational scan of a drug efflux pump reveals its structure–function landscape
Drug efflux is a common resistance mechanism found in bacteria and cancer cells, but studies providing comprehensive funct...
A potent and broad neutralization of SARS-CoV-2 variants of concern by DARPins
A potent and broad neutralization of SARS-CoV-2 variants of concern by DARPins
We report the engineering and selection of two synthetic proteins—FSR16m and FSR22—for the possible treatment ...
Insights into distinct signaling profiles of the µOR activated by diverse agonists
Insights into distinct signaling profiles of the µOR activated by diverse agonists
Drugs targeting the μ-opioid receptor (μOR) are the most effective analgesics available but are also associated ...
Popping at the poles
The polar organizing protein PopZ is an intrinsically disordered protein that regulates asymmetric cell division by formin...
The right angle
The immunoinhibitory receptor PD-1 and its ligand PD-L1 exhibit a flat, undruggable interaction interface formed by rich β...
A solid transition
A solid transition
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Crowd control
Crowd control
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Adjusting the spikes
Autophagy proceeds through several defined steps, with autophagosome formation being critical for the delivery of cytoplas...
Searching for a chaperone
A hallmark of amyotrophic lateral sclerosis is the presence of cytoplasmic aggregates that contain the essential nuclear p...
Publisher Correction: Parallel pathways for serotonin biosynthesis and metabolism in C. elegans
Authors and AffiliationsBoyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ith...
Prospering phase separation
Phase separation is an important mechanism for biomolecule condensate assembly and is involved in multiple biological acti...
Condensation of SEUSS promotes hyperosmotic stress tolerance in Arabidopsis
Condensation of SEUSS promotes hyperosmotic stress tolerance in Arabidopsis
Osmotic stress imposed by drought and high salinity inhibits plant growth and crop yield. However, our current knowledge o...
Chemical inhibition of DPP9 sensitizes the CARD8 inflammasome in HIV-1-infected cells
Chemical inhibition of DPP9 sensitizes the CARD8 inflammasome in HIV-1-infected cells
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) induce pyroptosis of HIV-1-infected CD4+ T cells through inductio...
Velcrin-induced selective cleavage of tRNALeu(TAA) by SLFN12 causes cancer cell death
Velcrin-induced selective cleavage of tRNALeu(TAA) by SLFN12 causes cancer cell death
Velcrin compounds kill cancer cells expressing high levels of phosphodiesterase 3A (PDE3A) and Schlafen family member 12 (...
Structural basis of TRPV3 inhibition by an antagonist
Structural basis of TRPV3 inhibition by an antagonist
The TRPV3 channel plays vital roles in skin physiology. Dysfunction of TRPV3 causes skin diseases, including Olmsted syndr...
Ligand recognition and allosteric modulation of the human MRGPRX1 receptor
Ligand recognition and allosteric modulation of the human MRGPRX1 receptor
The human MAS-related G protein–coupled receptor X1 (MRGPRX1) is preferentially expressed in the small-diameter prim...
Small-molecule inhibition of the archetypal UbiB protein COQ8
Small-molecule inhibition of the archetypal UbiB protein COQ8
Small-molecule tools have enabled mechanistic investigations and therapeutic targeting of the protein kinase-like (PKL) su...
cIAP1-based degraders induce degradation via branched ubiquitin architectures
cIAP1-based degraders induce degradation via branched ubiquitin architectures
Targeted protein degradation through chemical hijacking of E3 ubiquitin ligases is an emerging concept in precision medici...
Probing coenzyme A homeostasis with semisynthetic biosensors
Probing coenzyme A homeostasis with semisynthetic biosensors
Coenzyme A (CoA) is one of the central cofactors of metabolism, yet a method for measuring its concentration in living cel...
Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders
Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders
Targeted protein degradation is a novel pharmacology established by drugs that recruit target proteins to E3 ubiquitin lig...
Caught in the act
Caught in the act
YcaO enzymes are able to catalyze a diverse set of reactions and have found industrial applications. New biochemical data ...
Ferredoxins at the crossroads
Ferredoxins at the crossroads
Ferredoxins are universal electron donors. A study focusing on the two human mitochondrial ferredoxins reveals the existen...
A collaborative synthetase
A collaborative synthetase
Studies of the microbiome–host interaction are uncovering the metabolic mutual crosstalk between host tissues and gu...
A radical way to avoid cell death
A radical way to avoid cell death
Ferroptosis is a mechanism of cell death that has possible roles in numerous diseases. Two new studies have identified hyd...
Functional spectrum and specificity of mitochondrial ferredoxins FDX1 and FDX2
Functional spectrum and specificity of mitochondrial ferredoxins FDX1 and FDX2
Ferredoxins comprise a large family of iron–sulfur (Fe–S) proteins that shuttle electrons in diverse biologica...
YcaO-mediated ATP-dependent peptidase activity in ribosomal peptide biosynthesis
YcaO-mediated ATP-dependent peptidase activity in ribosomal peptide biosynthesis
YcaO enzymes catalyze ATP-dependent post-translation modifications on peptides, including the installation of (ox/thi)azol...
Hepatic glutamine synthetase controls N5-methylglutamine in homeostasis and cancer
Hepatic glutamine synthetase controls N5-methylglutamine in homeostasis and cancer
Glutamine synthetase (GS) activity is conserved from prokaryotes to humans, where the ATP-dependent production of glutamin...