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All roads lead to OSBP
All roads lead to OSBP
Natural products and synthetic bifunctional molecules enable the development of new chemical probes that target oxysterol-...
Recording calcium concentrations
Recording calcium concentrations
Identifying the protein component of calcium signaling in specific subcellular regions presents considerable challenges. R...
Inhibition of OSBP blocks retrograde trafficking by inducing partial Golgi degradation
Inhibition of OSBP blocks retrograde trafficking by inducing partial Golgi degradation
Sterol-binding proteins are important regulators of lipid homeostasis and membrane integrity; however, the discovery of se...
Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting OSBP
Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting OSBP
Metabolic alterations in cancer precipitate in associated dependencies that can be therapeutically exploited. To meet this...
The power and pitfalls of AlphaFold2 for structure prediction beyond rigid globular proteins
The power and pitfalls of AlphaFold2 for structure prediction beyond rigid globular proteins
Artificial intelligence-driven advances in protein structure prediction in recent years have raised the question: has the ...
Channeling kynurenine
Channeling kynurenine
An in vivo chemical screen has uncovered a potential role for a tryptophan metabolite in promoting host survival during ba...
3-Hydroxykynurenine targets kainate receptors to promote defense against infection
3-Hydroxykynurenine targets kainate receptors to promote defense against infection
Bacterial infection involves a complex interaction between the pathogen and host where the outcome of infection is not sol...
Rationally seeded computational protein design of ɑ-helical barrels
Rationally seeded computational protein design of ɑ-helical barrels
Computational protein design is advancing rapidly. Here we describe efficient routes starting from validated parallel and ...
Architecture of the RNF1 complex that drives biological nitrogen fixation
Architecture of the RNF1 complex that drives biological nitrogen fixation
Biological nitrogen fixation requires substantial metabolic energy in form of ATP as well as low-potential electrons that ...
Quantitative control of subcellular protein localization with a photochromic dimerizer
Quantitative control of subcellular protein localization with a photochromic dimerizer
Artificial control of intracellular protein dynamics with high precision provides deep insight into complicated biomolecul...
The realization of CRISPR gene therapy
The realization of CRISPR gene therapy
The inaugural CRISPR-based drug Casgevy has been approved by several medical agencies, with other CRISPR-based therapies c...
Optimizing multicopy chromosomal integration for stable high-performing strains
Optimizing multicopy chromosomal integration for stable high-performing strains
The copy number of genes in chromosomes can be modified by chromosomal integration to construct efficient microbial cell f...
A de novo designed coiled coil-based switch regulates the microtubule motor kinesin-1
A de novo designed coiled coil-based switch regulates the microtubule motor kinesin-1
Many enzymes are allosterically regulated via conformational change; however, our ability to manipulate these structural c...
High-resolution structure of a novel fluorogenic RNA aptamer
High-resolution structure of a novel fluorogenic RNA aptamer
Fluorogenic RNA aptamers have previously been developed to enhance RNA imaging. We determined the tertiary complex structu...
Mechanisms of neutralization of toxSAS from toxin–antitoxin modules
Mechanisms of neutralization of toxSAS from toxin–antitoxin modules
Toxic small alarmone synthetase (toxSAS) enzymes constitute a family of bacterial effectors present in toxin–antitox...
A bright green tag for RNA imaging
A bright green tag for RNA imaging
To understand the complex dynamics and diverse functions of RNA, robust technologies for labeling and imaging RNA are high...
Enediyne natural product biosynthesis unified by a diiodotetrayne intermediate
Enediyne natural product biosynthesis unified by a diiodotetrayne intermediate
Enediyne natural products are renowned for their potent cytotoxicities but the biosynthesis of their defining 1,5-diyne-3-...
De novo design of proteins housing excitonically coupled chlorophyll special pairs
De novo design of proteins housing excitonically coupled chlorophyll special pairs
Natural photosystems couple light harvesting to charge separation using a ‘special pair’ of chlorophyll molecu...
De novo design of buttressed loops for sculpting protein functions
De novo design of buttressed loops for sculpting protein functions
In natural proteins, structured loops have central roles in molecular recognition, signal transduction and enzyme catalysi...
Structural basis of a small monomeric Clivia fluorogenic RNA with a large Stokes shift
Structural basis of a small monomeric Clivia fluorogenic RNA with a large Stokes shift
RNA-based fluorogenic modules have revolutionized the spatiotemporal localization of RNA molecules. Recently, a fluorophor...
Antibody–peptide conjugates for targeted inhibition of cysteine proteases
Antibody–peptide conjugates for targeted inhibition of cysteine proteases
We developed a rational approach to design peptide-based covalent inhibitors and coupled the inhibitors with antibodies fo...
Antibody–peptide conjugates deliver covalent inhibitors blocking oncogenic cathepsins
Antibody–peptide conjugates deliver covalent inhibitors blocking oncogenic cathepsins
Cysteine cathepsins are a family of proteases that are relevant therapeutic targets for the treatment of different cancers...
Bump-hole ZDHHCs
Bump-hole ZDHHCs
The ZDHHC family of palmitoyl transferases lipidates numerous protein targets, but the paucity of selective inhibitors has...
PROTAC-ing tuberculosis
PROTAC-ing tuberculosis
Targeted protein degradation has emerged as a promising approach in drug discovery, harnessing a cell’s intrinsic ma...
Imaging the dynamics of messenger RNA with a bright and stable green fluorescent RNA
Imaging the dynamics of messenger RNA with a bright and stable green fluorescent RNA
Fluorescent RNAs (FRs) provide an attractive approach to visualizing RNAs in live cells. Although the color palette of FRs...
Transcriptional regulation of living materials via extracellular electron transfer
Transcriptional regulation of living materials via extracellular electron transfer
Engineered living materials combine the advantages of biological and synthetic systems by leveraging genetic and metabolic...
One-way Integrator
Bidirectional transcription initiation occurs at promoters where two RNA polymerase II (RNAPII) pre-initiation complexes (...
We don’t need no inflammation
The NF-κB pathway regulates inflammation in response to bacterial lipopolysaccharides (LPS) that are recognized by Toll-li...
Trapping the helicase
Cancers with microsatellite instability (MSI) are defined by the accumulation of insertion and/or deletion mutations in mi...
A key to unlock ubiquitin ligase function
A key to unlock ubiquitin ligase function
Reliably identifying ubiquitin ligase interactors and substrates has been a persistent challenge in cellular biology. A br...