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A key to sperm–egg union
The fusion of egg and sperm requires an egg surface protein, JUNO in mammals or Bouncer in fish, and several conserved spe...
Assembly-activated aggregation
The aberrant aggregation of the presynaptic protein α-synuclein (α-syn) is a hallmark of synucleinopathies, which include ...
Guiding the pioneer
Forkhead box protein A1 (FOXA1) is a pioneer transcription factor that binds to chromatin at a canonical DNA motif. This b...
Spatiotemporal control of subcellular O-GlcNAc signaling using Opto-OGT
Spatiotemporal control of subcellular O-GlcNAc signaling using Opto-OGT
The post-translational modification of intracellular proteins through O-linked β-N-acetylglucosamine (O-GlcNAc) is a ...
Open-ended molecular recording of sequential cellular events into DNA
Open-ended molecular recording of sequential cellular events into DNA
Genetically encoded DNA recorders noninvasively convert transient biological events into durable mutations in a cell’...
Author Correction: Evybactin is a DNA gyrase inhibitor that selectively kills Mycobacterium tuberculosis
Yu ImaiPresent address: Department of Biomolecular Innovation, Institute for Biomedical Sciences, Shinshu University, Naga...
Author Correction: ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway
These authors contributed equally: Jie Shi, Shangying Wang.Department of Bioengineering, University of California, Berkele...
Evading resistance at the double
Evading resistance at the double
Synthesis and characterization of new macrolones — fusions of two antibiotic classes with distinct bacterial targets...
A multiplex single-cell RNA-Seq pharmacotranscriptomics pipeline for drug discovery
A multiplex single-cell RNA-Seq pharmacotranscriptomics pipeline for drug discovery
The gene-regulatory dynamics governing drug responses in cancer are yet to be fully understood. Here, we report a pipeline...
Carbonic anhydrase inhibition ameliorates tau toxicity via enhanced tau secretion
Carbonic anhydrase inhibition ameliorates tau toxicity via enhanced tau secretion
Tauopathies are neurodegenerative diseases that manifest with intracellular accumulation and aggregation of tau protein. T...
Engineering a xylose fermenting yeast for lignocellulosic ethanol production
Engineering a xylose fermenting yeast for lignocellulosic ethanol production
Lignocellulosic ethanol is produced by yeast fermentation of lignocellulosic hydrolysates generated by chemical pretreatme...
Delineating cysteine-reactive compound modulation of cellular proteostasis processes
Delineating cysteine-reactive compound modulation of cellular proteostasis processes
Covalent modulators and covalent degrader molecules have emerged as drug modalities with tremendous therapeutic potential....
Genes and crystals are not so separate
Genes and crystals are not so separate
The mechanism underlying the formation of crystals in cells is not completely understood. An article now reports on the bi...
Selective bioorthogonal probe for N-glycan hybrid structures
Selective bioorthogonal probe for N-glycan hybrid structures
Metabolic incorporation of chemically tagged monosaccharides is a facile means of tagging cellular glycoproteins and glyco...
Protein Degradation in Focus
Protein Degradation in Focus
In May 2024, ‘Protein Degradation in Focus’, a special symposium aimed at bringing together scientists in the ...
Cracking the diversity of sweet drugs
Cracking the diversity of sweet drugs
Characterization of the heterogeneity in the glycosylation of biotherapeutics is crucial for drug development but challeng...
Stressing out with electrophiles
Stressing out with electrophiles
Covalent modification of cysteine by electrophilic small molecules enables broad targeting of the unliganded proteome. A s...
Bridging the gap in protein targeting
Targeted protein degradation has emerged as a highly promising therapeutic approach to modulate proteins that are difficul...
Forming folate-fortified rice
Folates are a group of water-soluble B vitamins that are essential for all organisms. Although plants and microbes can syn...
Molecular glue modulates mitochondria
Early-onset Parkinson’s disease (EOPD) is a movement disorder caused by loss of specific neurons in the midbrain that are ...
A cerium-dependent photoenzyme
Enzymes efficiently catalyze numerous reactions, but re-engineering them to speed up reactions that are not known in natur...
Predicting small-molecule partitioning
Biomolecular condensates perform their cellular functions via the exclusion or enrichment of molecules. Analyzing the comp...
Studying ATP synthesis in situ
Mitochondria have a crucial role in replenishing ATP, the molecule used to provide cellular energy. This is achieved by ti...
Targeting proteins to lysosomes with a chemical inducer of arginine methylation
Targeting proteins to lysosomes with a chemical inducer of arginine methylation
Arginine methylation acts as a signal for intracellular proteins to be degraded in lysosomes. We developed methylarginine ...
In vivo manipulation of human gut Bacteroides fitness by abiotic oligosaccharides
In vivo manipulation of human gut Bacteroides fitness by abiotic oligosaccharides
Synthetic glycans (SGs) containing glycosidic linkages and structures not identified in nature offer a means for deliberat...
Fucosylation of glycoproteins and glycolipids: opposing roles in cholera intoxication
Fucosylation of glycoproteins and glycolipids: opposing roles in cholera intoxication
Cholera toxin (CT) is the etiological agent of cholera. Here we report that multiple classes of fucosylated glycoconjugate...
Methylarginine targeting chimeras for lysosomal degradation of intracellular proteins
Methylarginine targeting chimeras for lysosomal degradation of intracellular proteins
A paradigm shift in drug development is the discovery of small molecules that harness the ubiquitin-proteasomal pathway to...
Paenilamicins are context-specific translocation inhibitors of protein synthesis
Paenilamicins are context-specific translocation inhibitors of protein synthesis
The paenilamicins are a group of hybrid nonribosomal peptide–polyketide compounds produced by the honey bee pathogen...
Designed with interactome-based deep learning
Designed with interactome-based deep learning
Predicting prospective drug-like molecules quickly and accurately is a considerable challenge for de novo drug design. An ...
ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway
ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway
Repurposing an organelle for specialized metabolism provides an avenue for fermentable, unicellular organisms such as Sacc...
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