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Pyro(phospho)mania
Pyro(phospho)mania
Understanding the role of pyrophosphorylation requires specific analytical strategies to discriminate it from protein phos...
Minimizing higher-order aggregation maximizes iron mobilization by small molecules
Minimizing higher-order aggregation maximizes iron mobilization by small molecules
The natural product hinokitiol mobilizes iron across lipid bilayers at low concentrations and restores hemoglobinization i...
Extensive protein pyrophosphorylation revealed in human cell lines
Extensive protein pyrophosphorylation revealed in human cell lines
Reversible protein phosphorylation is a central signaling mechanism in eukaryotes. Although mass-spectrometry-based phosph...
Structural basis for α-tubulin-specific and modification state-dependent glutamylation
Structural basis for α-tubulin-specific and modification state-dependent glutamylation
Microtubules have spatiotemporally complex posttranslational modification patterns. Tubulin tyrosine ligase-like (TTLL) en...
Molecular recording of calcium signals via calcium-dependent proximity labeling
Molecular recording of calcium signals via calcium-dependent proximity labeling
Calcium ions serve as key intracellular signals. Local, transient increases in calcium concentrations can activate calcium...
Author Correction: Engineering a precise adenine base editor with minimal bystander editing
These authors contributed equally: Liang Chen, Shun Zhang, Niannian Xue, Mengjia Hong, Xiaohui Zhang.Shanghai Frontiers Sc...
Author Correction: Fructose-1,6-bisphosphatase 1 dephosphorylates and inhibits TERT for tumor suppression
These authors contributed equally: Min Li, Zheng Wang, Jingjing Tao.Zhejiang Provincial Key Laboratory of Pancreatic Disea...
Addendum: Designing microbial consortia with defined social interactions
Addendum: Designing microbial consortia with defined social interactions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
UFL1 triggers replication fork degradation by MRE11 in BRCA1/2-deficient cells
UFL1 triggers replication fork degradation by MRE11 in BRCA1/2-deficient cells
The stabilization of stalled forks has emerged as a crucial mechanism driving resistance to poly(ADP-ribose) polymerase (P...
Forced rewiring of RTK signaling
Forced rewiring of RTK signaling
Reprogramming intercellular mechanotransduction and signaling pathways is still challenging. A recent advance uses a plug-...
A peptide dehydratase with core strength
A peptide dehydratase with core strength
Ribosomally synthesized and post-translationally modified peptide (RiPP) natural products typically rely on substrate reco...
Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning
Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning
Machine learning methods hold the promise to reduce the costs and the failure rates of conventional drug discovery pipelin...
Bringing chemistry to medicine to redefine the undruggable
Bringing chemistry to medicine to redefine the undruggable
Chemical approaches, such as those that leverage induced proximity, targeted degradation, synthetic gene regulators or pro...
Peptide vaccines get an OS update
Peptide vaccines get an OS update
Peptide vaccines use antigenic peptide fragments to induce an immune response but are problematic because of the short hal...
LPS gets a fresh trim
LPS gets a fresh trim
Detection of intracellular lipolysaccharide (LPS) activates an immune response initiated by the non-canonical inflammasome...
Engineering APOBEC3A deaminase for highly accurate and efficient base editing
Engineering APOBEC3A deaminase for highly accurate and efficient base editing
Cytosine base editors (CBEs) are effective tools for introducing C-to-T base conversions, but their clinical applications ...
Fructose-1,6-bisphosphatase 1 dephosphorylates and inhibits TERT for tumor suppression
Fructose-1,6-bisphosphatase 1 dephosphorylates and inhibits TERT for tumor suppression
Telomere dysfunction is intricately linked to the aging process and stands out as a prominent cancer hallmark. Here we dem...
Stress it up
AKT is a serine/threonine kinase that is essential for cellular metabolism and proliferation and is overactive in cancer c...
Reeling in microorganisms
The metabolic engineering of microorganisms is an attractive platform for bioremediation and the industrial production of ...
Switching off the stress response
Cells respond to adverse environmental changes by activating stress response pathways. However, the continuous activation ...
Profiling the proximal proteome of the activated μ-opioid receptor
Profiling the proximal proteome of the activated μ-opioid receptor
The μ-opioid receptor (μOR) represents an important target of therapeutic and abused drugs. So far, most underst...
Targeting the chromatin binding of exportin-1 disrupts NFAT and T cell activation
Targeting the chromatin binding of exportin-1 disrupts NFAT and T cell activation
Exportin-1 (XPO1/CRM1) plays a central role in the nuclear-to-cytoplasmic transport of hundreds of proteins and contribute...
The death gaze of MEDUSA
The death gaze of MEDUSA
Chemogenetic profiling can reveal genetic determinants that coordinate phenotypic responses to therapeutics, along with pr...
Global signal peptide profiling reveals principles of selective Sec61 inhibition
Global signal peptide profiling reveals principles of selective Sec61 inhibition
Cotransins target the Sec61 translocon and inhibit the biogenesis of an undefined subset of secretory and membrane protein...
Design of amyloidogenic peptide traps
Design of amyloidogenic peptide traps
Segments of proteins with high β-strand propensity can self-associate to form amyloid fibrils implicated in many dise...
Sulfide oxidation promotes hypoxic angiogenesis and neovascularization
Sulfide oxidation promotes hypoxic angiogenesis and neovascularization
Angiogenic programming in the vascular endothelium is a tightly regulated process for maintaining tissue homeostasis and i...
Ripping and stitching with copper
Ripping and stitching with copper
BURP-domain proteins belong to an emerging class of autocatalytic copper-containing proteins that modify themselves after ...
Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates
Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates
Protein ubiquitylation controls diverse processes within eukaryotic cells, including protein degradation, and is often dys...
Accessing natural vaccine adjuvants
Accessing natural vaccine adjuvants
An integrative approach has now enabled elucidation of the complete biosynthetic pathway of a prominent saponin adjuvant. ...
Functional genomic screens with death rate analyses reveal mechanisms of drug action
Functional genomic screens with death rate analyses reveal mechanisms of drug action
A common approach for understanding how drugs induce their therapeutic effects is to identify the genetic determinants of ...
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