SCI时时刷

search
+
Proteins dance to the tune of light
Proteins dance to the tune of light
Versatile methods for rapid, reversible and repetitive control of protein localization are lacking. A novel optically cont...
The chemical language of protein glycation
The chemical language of protein glycation
Glycation is a non-enzymatic post-translational modification (PTM) that is correlated with many diseases, including diabet...
Potent and specific antibiotic combination therapy against Clostridioides difficile
Potent and specific antibiotic combination therapy against Clostridioides difficile
Keratinicyclins and keratinimicins are recently discovered glycopeptide antibiotics. Keratinimicins show broad-spectrum ac...
Identifying p53-independent apoptosis
The p53 protein is a key transcription factor responsible for inducing apoptosis in response to DNA damage, such as damage...
A direct hit
Treating Gram-negative bacteria with antibiotics remains difficult due to the lack of a target that is specific for this p...
On the quest for mescaline
Mescaline, a substituted phenethylamine protoalkaloid, is the primary hallucinogenic compound in psychedelic cacti such as...
All roads lead to OSBP
All roads lead to OSBP
Natural products and synthetic bifunctional molecules enable the development of new chemical probes that target oxysterol-...
Recording calcium concentrations
Recording calcium concentrations
Identifying the protein component of calcium signaling in specific subcellular regions presents considerable challenges. R...
Inhibition of OSBP blocks retrograde trafficking by inducing partial Golgi degradation
Inhibition of OSBP blocks retrograde trafficking by inducing partial Golgi degradation
Sterol-binding proteins are important regulators of lipid homeostasis and membrane integrity; however, the discovery of se...
Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting OSBP
Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting OSBP
Metabolic alterations in cancer precipitate in associated dependencies that can be therapeutically exploited. To meet this...
The power and pitfalls of AlphaFold2 for structure prediction beyond rigid globular proteins
The power and pitfalls of AlphaFold2 for structure prediction beyond rigid globular proteins
Artificial intelligence-driven advances in protein structure prediction in recent years have raised the question: has the ...
Channeling kynurenine
Channeling kynurenine
An in vivo chemical screen has uncovered a potential role for a tryptophan metabolite in promoting host survival during ba...
3-Hydroxykynurenine targets kainate receptors to promote defense against infection
3-Hydroxykynurenine targets kainate receptors to promote defense against infection
Bacterial infection involves a complex interaction between the pathogen and host where the outcome of infection is not sol...
Rationally seeded computational protein design of ɑ-helical barrels
Rationally seeded computational protein design of ɑ-helical barrels
Computational protein design is advancing rapidly. Here we describe efficient routes starting from validated parallel and ...
Architecture of the RNF1 complex that drives biological nitrogen fixation
Architecture of the RNF1 complex that drives biological nitrogen fixation
Biological nitrogen fixation requires substantial metabolic energy in form of ATP as well as low-potential electrons that ...
Quantitative control of subcellular protein localization with a photochromic dimerizer
Quantitative control of subcellular protein localization with a photochromic dimerizer
Artificial control of intracellular protein dynamics with high precision provides deep insight into complicated biomolecul...
The realization of CRISPR gene therapy
The realization of CRISPR gene therapy
The inaugural CRISPR-based drug Casgevy has been approved by several medical agencies, with other CRISPR-based therapies c...
Optimizing multicopy chromosomal integration for stable high-performing strains
Optimizing multicopy chromosomal integration for stable high-performing strains
The copy number of genes in chromosomes can be modified by chromosomal integration to construct efficient microbial cell f...
A de novo designed coiled coil-based switch regulates the microtubule motor kinesin-1
A de novo designed coiled coil-based switch regulates the microtubule motor kinesin-1
Many enzymes are allosterically regulated via conformational change; however, our ability to manipulate these structural c...
High-resolution structure of a novel fluorogenic RNA aptamer
High-resolution structure of a novel fluorogenic RNA aptamer
Fluorogenic RNA aptamers have previously been developed to enhance RNA imaging. We determined the tertiary complex structu...
Mechanisms of neutralization of toxSAS from toxin–antitoxin modules
Mechanisms of neutralization of toxSAS from toxin–antitoxin modules
Toxic small alarmone synthetase (toxSAS) enzymes constitute a family of bacterial effectors present in toxin–antitox...
A bright green tag for RNA imaging
A bright green tag for RNA imaging
To understand the complex dynamics and diverse functions of RNA, robust technologies for labeling and imaging RNA are high...
Enediyne natural product biosynthesis unified by a diiodotetrayne intermediate
Enediyne natural product biosynthesis unified by a diiodotetrayne intermediate
Enediyne natural products are renowned for their potent cytotoxicities but the biosynthesis of their defining 1,5-diyne-3-...
De novo design of proteins housing excitonically coupled chlorophyll special pairs
De novo design of proteins housing excitonically coupled chlorophyll special pairs
Natural photosystems couple light harvesting to charge separation using a ‘special pair’ of chlorophyll molecu...
De novo design of buttressed loops for sculpting protein functions
De novo design of buttressed loops for sculpting protein functions
In natural proteins, structured loops have central roles in molecular recognition, signal transduction and enzyme catalysi...
Structural basis of a small monomeric Clivia fluorogenic RNA with a large Stokes shift
Structural basis of a small monomeric Clivia fluorogenic RNA with a large Stokes shift
RNA-based fluorogenic modules have revolutionized the spatiotemporal localization of RNA molecules. Recently, a fluorophor...
Antibody–peptide conjugates for targeted inhibition of cysteine proteases
Antibody–peptide conjugates for targeted inhibition of cysteine proteases
We developed a rational approach to design peptide-based covalent inhibitors and coupled the inhibitors with antibodies fo...
Antibody–peptide conjugates deliver covalent inhibitors blocking oncogenic cathepsins
Antibody–peptide conjugates deliver covalent inhibitors blocking oncogenic cathepsins
Cysteine cathepsins are a family of proteases that are relevant therapeutic targets for the treatment of different cancers...
Bump-hole ZDHHCs
Bump-hole ZDHHCs
The ZDHHC family of palmitoyl transferases lipidates numerous protein targets, but the paucity of selective inhibitors has...
PROTAC-ing tuberculosis
PROTAC-ing tuberculosis
Targeted protein degradation has emerged as a promising approach in drug discovery, harnessing a cell’s intrinsic ma...
阅读更多
format_indent_increase