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Unraveling the diversity of molecular glue degraders
Unraveling the diversity of molecular glue degraders
By investigating the structure–activity relationship of molecular glue degraders that target cyclin K, we discovered...
Molecular basis and engineering of miniature Cas12f with C-rich PAM specificity
Molecular basis and engineering of miniature Cas12f with C-rich PAM specificity
CRISPR–Cas12f nucleases are currently one of the smallest genome editors, exhibiting advantages for efficient delive...
Design principles for cyclin K molecular glue degraders
Design principles for cyclin K molecular glue degraders
Molecular glue degraders are an effective therapeutic modality, but their design principles are not well understood. Recen...
Motif-dependent binding on the intervening domain regulates O-GlcNAc transferase
Motif-dependent binding on the intervening domain regulates O-GlcNAc transferase
The modification of intracellular proteins with O-linked β-N-acetylglucosamine (O-GlcNAc) moieties is a highly dynami...
Hunting down the shapeshifters
Hunting down the shapeshifters
Newly developed synthetic antibodies offer the means to be used as high-affinity, conformation-specific probes to capture ...
Calcium-gated potassium channel blockade via membrane-facing fenestrations
Calcium-gated potassium channel blockade via membrane-facing fenestrations
Quaternary ammonium blockers were previously shown to bind in the pore to block both open and closed conformations of larg...
Activity-based profiling of cullin–RING E3 networks by conformation-specific probes
Activity-based profiling of cullin–RING E3 networks by conformation-specific probes
The cullin–RING ubiquitin ligase (CRL) network comprises over 300 unique complexes that switch from inactive to acti...
Hydroxytryptophan biosynthesis by a family of heme-dependent enzymes in bacteria
Hydroxytryptophan biosynthesis by a family of heme-dependent enzymes in bacteria
Hydroxytryptophan serves as a chemical precursor to a variety of bioactive specialized metabolites, including the human ne...
Author Correction: NADP modulates RNA m6A methylation and adipogenesis via enhancing FTO activity
Author notesThese authors contributed equally: Lina Wang, Chengli Song, Na Wang.Authors and AffiliationsInstitute of Cance...
Author Correction: Histone tyrosine sulfation by SULT1B1 regulates H4R3me2a and gene transcription
These authors contributed equally: Weixing Yu, Runxin Zhou.These authors jointly supervised this work: Ke Liu, Yugang Wang...
Overview of chemical biology at the National Natural Science Foundation of China
Overview of chemical biology at the National Natural Science Foundation of China
Since its proposition in 2002, the Division of Chemical Biology in the Department of Chemical Sciences at the National Nat...
Linked to death
Linked to death
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
Seeing α-synuclein fibrils
Seeing α-synuclein fibrils
By analyzing skeletons of known α-Syn ligands and positron emission tomography tracers of amyloid-β fibrils, the authors n...
Lighting up DNA
Recent advances in metabolic labeling include the use of fluorescent triphosphates that can be incorporated into cellular ...
Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5
Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5
Ubiquitin (Ub) chain formation by homologous to E6AP C-terminus (HECT)-family E3 ligases regulates vast biology, yet the s...
Engineering co-utilization of glucose and xylose for chemical overproduction from lignocellulose
Engineering co-utilization of glucose and xylose for chemical overproduction from lignocellulose
Bio-refining lignocellulose could provide a sustainable supply of fuels and fine chemicals; however, the challenges associ...
RNA repeats stall translation
RNA repeats stall translation
CAG triple-nucleotide repeats in multiple genes have been linked to various human diseases. A recent study unveils the eff...
A high-throughput screening platform for enzymes active on mucin-type O-glycoproteins
A high-throughput screening platform for enzymes active on mucin-type O-glycoproteins
Mucin-type O-glycosylation is a post-translational modification present at the interface between cells where it has import...
Gelation of cytoplasmic expanded CAG RNA repeats suppresses global protein synthesis
Gelation of cytoplasmic expanded CAG RNA repeats suppresses global protein synthesis
RNA molecules with the expanded CAG repeat (eCAGr) may undergo sol–gel phase transitions, but the functional impact ...
Capturing receptor states with glue
Capturing receptor states with glue
A universally effective method has been developed to enable cryo-electron microscopy structural determination of G protein...
A method for structure determination of GPCRs in various states
A method for structure determination of GPCRs in various states
G-protein-coupled receptors (GPCRs) are a class of integral membrane proteins that detect environmental cues and trigger c...
A chemical solution for FRET(ful) pairs
A chemical solution for FRET(ful) pairs
The development of biosensors has been slowed by the optimization required for each new iteration. Now, the ChemoX platfor...
Structure and mechanism of a neuropeptide-activated channel in the ENaC/DEG superfamily
Structure and mechanism of a neuropeptide-activated channel in the ENaC/DEG superfamily
Phe-Met-Arg-Phe-amide (FMRFamide)-activated sodium channels (FaNaCs) are a family of channels activated by the neuropeptid...
Computational design and genetic incorporation of lipidation mimics in living cells
Computational design and genetic incorporation of lipidation mimics in living cells
Protein lipidation, which regulates numerous biological pathways and plays crucial roles in the pharmaceutical industry, i...
Structural insight into selectivity of amylin and calcitonin receptor agonists
Structural insight into selectivity of amylin and calcitonin receptor agonists
Amylin receptors (AMYRs), heterodimers of the calcitonin receptor (CTR) and one of three receptor activity-modifying prote...
A parallel glycolysis provides a selective advantage through rapid growth acceleration
A parallel glycolysis provides a selective advantage through rapid growth acceleration
Glycolysis is a universal metabolic process that breaks down glucose to produce adenosine triphosphate (ATP) and biomass p...
Cooperative demethylation
N6-methyladenosine (m6A) methylation is one of the most abundant modifications in mRNA, with its installation and removal ...
Click, release, destroy
Click, release, destroy
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
Phasing out death
Phasing out death
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
Endosome positioning coordinates spatially selective GPCR signaling
Endosome positioning coordinates spatially selective GPCR signaling
G-protein-coupled receptors (GPCRs) can initiate unique functional responses depending on the subcellular site of activati...
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