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Time to Revisit Using 10-Year Risk to Guide Statin Therapy
Time to Revisit Using 10-Year Risk to Guide Statin Therapy
Similar to the US, the European Society for Cardiology (ESC) guidelines have long used a 10-year risk score to guide stati...
Very Elevated High-Density Lipoprotein Cholesterol and Mortality
Very Elevated High-Density Lipoprotein Cholesterol and Mortality
A wealth of evidence supports the mechanistic role of high-density lipoprotein cholesterol (HDL-C) in promoting reverse ch...
Passing the Stethoscope
Passing the Stethoscope
This essay describes the author’s father, a surgeon, passing the baton on to him as a second-generation pysician.
Behind the Hospital Curtain
Behind the Hospital Curtain
This essay describes a physician’s experience becoming a patient for the first time and the valuable knowledge this experi...
When an Aortic Bioprosthesis Fails in a Low-risk Patient
When an Aortic Bioprosthesis Fails in a Low-risk Patient
This Viewpoint discusses the need for randomized clinical trial data to determine the optimal treatment strategy for patie...
Noninferiority Margins in Clinical Trials—A Moving Target?
Noninferiority Margins in Clinical Trials—A Moving Target?
Noninferiority trials, often referred to as the “as good as” trials, are the most common current pivotal study designs use...
Updated USPSTF Guidelines for Screening for Atrial Fibrillation
Updated USPSTF Guidelines for Screening for Atrial Fibrillation
This Editorial discusses atrial fibrillation screening recommendations from the US Preventive Services Task Force.
The Right Time for a Heart Valve Replacement
The Right Time for a Heart Valve Replacement
This essay describes the author’s 80-year heart valve journey and the advances that have been made over that time.
ApoB vs LDL-Cholesterol and Non-HDL-C as the Primary Measure of ApoB Lipoprotein-Related Risk
ApoB vs LDL-Cholesterol and Non-HDL-C as the Primary Measure of ApoB Lipoprotein-Related Risk
In 1979, Avogaro et al reported that apolipoprotein B (apoB) was a more accurate marker of the risk of a myocardial infarc...
The Potential and Pitfalls of Coronary Artery Calcium Scoring
The Potential and Pitfalls of Coronary Artery Calcium Scoring
Among asymptomatic middle-aged to older adults, one of the most sensitive, reliable, and reproducible ways of noninvasivel...
Coronary Artery Calcium Testing in the Prevention of Atherosclerotic Cardiovascular Disease
Coronary Artery Calcium Testing in the Prevention of Atherosclerotic Cardiovascular Disease
This narrative review provides an overview of coronary artery calcium testing as a tool for risk assessment in the prevent...
Transforming the Paradigm for Lipid Lowering
Transforming the Paradigm for Lipid Lowering
Decades of research have demonstrated that low-density lipoprotein cholesterol (LDL-C) is a causative factor in the develo...
Premature CAC in Primary and Secondary Prevention of Atherosclerotic Cardiovascular Disease
Premature CAC in Primary and Secondary Prevention of Atherosclerotic Cardiovascular Disease
This Viewpoint discusses the potential value of incidentally observed coronary artery calcification (CAC) in deciding to i...
Temporal Associations Between Immunization With the COVID-19 mRNA Vaccines and Myocarditis
Temporal Associations Between Immunization With the COVID-19 mRNA Vaccines and Myocarditis
Prior reports of adverse events following immunization for measles, mumps, and rubella, later deemed unsubstantiated, rais...
Imposter Syndrome
Imposter Syndrome
This essay discusses the author’s experience with imposter syndrome.
Myocarditis Occurring After Immunization With mRNA-Based COVID-19 Vaccines
Myocarditis Occurring After Immunization With mRNA-Based COVID-19 Vaccines
Two reports in the current issue of JAMA Cardiology describe cases of acute myocarditis that occurred among persons who re...
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