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APS celebrates the 90th anniversary of SIMM
Acta Pharmacologica Sinica (APS) proudly celebrates the 90th anniversary of the establishment of Shanghai...
Antitumor pharmacological research in the era of personalized medicine
Antitumor pharmacological research in the era of personalized medicine
Anticancer drug discovery has yielded unprecedented progress in recent decades, resulting in the approval of innovative tr...
Targeting PI3Kα overcomes resistance to KRasG12C inhibitors mediated by activation of EGFR and/or IGF1R
Targeting PI3Kα overcomes resistance to KRasG12C inhibitors mediated by activation of EGFR and/or IGF1R
Although several KRasG12C inhibitors have displayed promising efficacy in clinical settings, acquired resistance developed...
Ginsenoside Rg1 in neurological diseases: From bench to bedside
Ginsenoside Rg1 in neurological diseases: From bench to bedside
Ginseng has been used in China as a superior medicinal material for thousands of years that can nourish the five internal ...
Author Correction: Darinaparsin (ZIO-101) enhances the sensitivity of small-cell lung cancer to PARP inhibitors
Author Correction: Darinaparsin (ZIO-101) enhances the sensitivity of small-cell lung cancer to PARP inhibitors
High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230031, ChinaGuo...
Proteomic characterization of post-translational modifications in drug discovery
Proteomic characterization of post-translational modifications in drug discovery
Protein post-translational modifications (PTMs), which are usually enzymatically catalyzed, are major regulators ...
Inhibiting von Hippel‒Lindau protein-mediated Dishevelled ubiquitination protects against experimental parkinsonism
Inhibiting von Hippel‒Lindau protein-mediated Dishevelled ubiquitination protects against experimental parkinsonism
Dopaminergic neuron degeneration is a hallmark of Parkinson’s disease (PD). We previously reported that the inactiva...
Alpha lipoamide inhibits diabetic kidney fibrosis via improving mitochondrial function and regulating RXRα expression and activation
Alpha lipoamide inhibits diabetic kidney fibrosis via improving mitochondrial function and regulating RXRα expression and activation
Previous studies have shown mitochondrial dysfunction in various acute kidney injuries and chronic kidney diseases. Lipoic...
Melatonin ameliorates bleomycin-induced pulmonary fibrosis via activating NRF2 and inhibiting galectin-3 expression
Melatonin ameliorates bleomycin-induced pulmonary fibrosis via activating NRF2 and inhibiting galectin-3 expression
Pulmonary fibrosis (PF) is a chronic interstitial lung disease with no effective therapies. Galectin-3 (Gal-3), a marker o...
Hernandezine induces autophagic cell death in human pancreatic cancer cells via activation of the ROS/AMPK signaling pathway
Hernandezine induces autophagic cell death in human pancreatic cancer cells via activation of the ROS/AMPK signaling pathway
Hernandezine (Her) is a bisbenzylisoquinoline alkaloid extracted from the traditional Chinese herbal medicine Thalictrum g...
JP1, a polypeptide specifically targeting integrin αVβ3, ameliorates choroidal neovascularization and diabetic retinopathy in mice
JP1, a polypeptide specifically targeting integrin αVβ3, ameliorates choroidal neovascularization and diabetic retinopathy in mice
Anti-vascular endothelial growth factor (VEGF) drugs have revolutionized the treatment of neovascular eye diseases, but re...
Kelch-like proteins in the gastrointestinal tumors
Kelch-like proteins in the gastrointestinal tumors
Gastrointestinal tumors have become a worldwide health problem with high morbidity and poor clinical outcomes. Chemotherap...
Comparison of two methods for tumour-targeting peptide modification of liposomes
Comparison of two methods for tumour-targeting peptide modification of liposomes
Liposomes decorated with tumour-targeting cell-penetrating peptides can enhance specific drug delivery at the tumour site....
Darinaparsin (ZIO-101) enhances the sensitivity of small-cell lung cancer to PARP inhibitors
Darinaparsin (ZIO-101) enhances the sensitivity of small-cell lung cancer to PARP inhibitors
Small-cell lung cancer (SCLC) is an aggressive high-grade neuroendocrine carcinoma of the lung associated with early metas...
Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies
Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies
The fight against coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is still raging. However, the pathoph...
Publisher Correction: Publisher correction for multiple articles
The original versions of the articles with the above DOIs were unfortunately missing the Open Access License text: This ar...
SNS-023 sensitizes hepatocellular carcinoma to sorafenib by inducing degradation of cancer drivers SIX1 and RPS16
SNS-023 sensitizes hepatocellular carcinoma to sorafenib by inducing degradation of cancer drivers SIX1 and RPS16
Hepatocellular carcinoma (HCC) remains challenging due to the lack of efficient therapy. Promoting degradation of certain ...
DrugRep: an automatic virtual screening server for drug repurposing
DrugRep: an automatic virtual screening server for drug repurposing
Computationally identifying new targets for existing drugs has drawn much attention in drug repurposing due to its advanta...
Hyperthermia promotes degradation of the acute promyelocytic leukemia driver oncoprotein ZBTB16/RARα
Hyperthermia promotes degradation of the acute promyelocytic leukemia driver oncoprotein ZBTB16/RARα
The acute promyelocytic leukemia (APL) driver ZBTB16/RARα is generated by the t(11;17) (q23;q21) chromosomal transloc...
Mitofusin-2 mediates cannabidiol-induced neuroprotection against cerebral ischemia in rats
Mitofusin-2 mediates cannabidiol-induced neuroprotection against cerebral ischemia in rats
Cannabidiol (CBD) reportedly exerts protective effects against many psychiatric disorders and neurodegenerative diseases, ...
Metrnl regulates cognitive dysfunction and hippocampal BDNF levels in D-galactose-induced aging mice
Metrnl regulates cognitive dysfunction and hippocampal BDNF levels in D-galactose-induced aging mice
Aging is one of the main risk factors for cognitive dysfunction. During aging process, the decrease of brain-derived neuro...
Discovery and characterization of a novel cGAS covalent inhibitor for the treatment of inflammatory bowel disease
Discovery and characterization of a novel cGAS covalent inhibitor for the treatment of inflammatory bowel disease
Cyclic GMP-AMP synthase (cGAS), a cytosolic DNA sensor, acts as a nucleotidyl transferase that catalyzes ATP and GTP to fo...
Mass spectrometry imaging: new eyes on natural products for drug research and development
Mass spectrometry imaging: new eyes on natural products for drug research and development
Natural products (NPs) and their structural analogs represent a major source of novel drug development for disease prevent...