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Liver receptor homolog-1: structures, related diseases, and drug discovery
Liver receptor homolog-1: structures, related diseases, and drug discovery
Liver receptor homolog-1 (LRH-1), a member of the nuclear receptor superfamily, is a ligand-regulated transcription factor...
Frizzled receptors (FZDs) in Wnt signaling: potential therapeutic targets for human cancers
Frizzled receptors (FZDs) in Wnt signaling: potential therapeutic targets for human cancers
Frizzled receptors (FZDs) are key contributors intrinsic to the Wnt signaling pathway, activation of FZDs triggering the W...
Transcriptional regulation and post-translational modifications in the glycolytic pathway for targeted cancer therapy
Transcriptional regulation and post-translational modifications in the glycolytic pathway for targeted cancer therapy
Cancer cells largely rely on aerobic glycolysis or the Warburg effect to generate essential biomolecules and energy for th...
Ripretinib inhibits HIV-1 transcription through modulation of PI3K-AKT-mTOR
Ripretinib inhibits HIV-1 transcription through modulation of PI3K-AKT-mTOR
Despite the effectiveness of antiretroviral therapy (ART) in prolonging the lifespan of individuals infected with HIV-1, i...
A novel bispecific antibody drug conjugate targeting HER2 and HER3 with potent therapeutic efficacy against breast cancer
A novel bispecific antibody drug conjugate targeting HER2 and HER3 with potent therapeutic efficacy against breast cancer
Antibody drug conjugate (ADC) therapy has become one of the most promising approaches in cancer immunotherapy. Bispecific ...
The classical D1 dopamine receptor antagonist SCH23390 is a functional sigma-1 receptor allosteric modulator
The classical D1 dopamine receptor antagonist SCH23390 is a functional sigma-1 receptor allosteric modulator
SCH23390 is a widely used D1 dopamine receptor (D1R) antagonist that also elicits some D1R-independent effects. We previou...
Novel STAT3 oligonucleotide compounds suppress tumor growth and overcome the acquired resistance to sorafenib in hepatocellular carcinoma
Novel STAT3 oligonucleotide compounds suppress tumor growth and overcome the acquired resistance to sorafenib in hepatocellular carcinoma
Signal transducer and activator of transcription 3 (STAT3) plays an important role in the occurrence and progression of tu...
Tumor-targeted PROTAC prodrug nanoplatform enables precise protein degradation and combination cancer therapy
Tumor-targeted PROTAC prodrug nanoplatform enables precise protein degradation and combination cancer therapy
Proteolysis targeting chimeras (PROTACs) have emerged as revolutionary anticancer therapeutics that degrade disease-causin...
Neutrophil extracellular traps promote acetaminophen-induced acute liver injury in mice via AIM2
Neutrophil extracellular traps promote acetaminophen-induced acute liver injury in mice via AIM2
Excessive acetaminophen (APAP) can induce neutrophil activation and hepatocyte death. Along with hepatocyte dysfunction an...
Empagliflozin and liraglutide ameliorate HFpEF in mice via augmenting the Erbb4 signaling pathway
Empagliflozin and liraglutide ameliorate HFpEF in mice via augmenting the Erbb4 signaling pathway
Heart failure with preserved ejection fraction (HFpEF) is closely associated with metabolic derangement. Sodium glucose co...
Exosomes derived from induced cardiopulmonary progenitor cells alleviate acute lung injury in mice
Exosomes derived from induced cardiopulmonary progenitor cells alleviate acute lung injury in mice
Cardiopulmonary progenitor cells (CPPs) constitute a minor subpopulation of cells that are commonly associated with heart ...
Inhibition of USP7 enhances CD8+ T cell activity in liver cancer by suppressing PRDM1-mediated FGL1 upregulation
Inhibition of USP7 enhances CD8+ T cell activity in liver cancer by suppressing PRDM1-mediated FGL1 upregulation
Lymphocyte activation gene 3 (LAG3), an immune checkpoint molecule expressed on activated T cells, functions as a negative...
Prebiotic diet normalizes aberrant immune and behavioral phenotypes in a mouse model of autism spectrum disorder
Prebiotic diet normalizes aberrant immune and behavioral phenotypes in a mouse model of autism spectrum disorder
Autism spectrum disorder (ASD) is a cluster of neurodevelopmental disorders characterized by deficits in communication and...
Indoxyl sulphate-TNFα axis mediates uremic encephalopathy in rodent acute kidney injury
Indoxyl sulphate-TNFα axis mediates uremic encephalopathy in rodent acute kidney injury
Acute kidney injury (AKI) is often accompanied by uremic encephalopathy resulting from accumulation of uremic toxins in br...
Decreasing mitochondrial fission ameliorates HIF-1α-dependent pathological retinal angiogenesis
Decreasing mitochondrial fission ameliorates HIF-1α-dependent pathological retinal angiogenesis
Angiogenesis plays a critical role in many pathological processes, including irreversible blindness in eye diseases such a...
A novel role of PSMB9 in endothelial cells and atherosclerosis: beyond its canonical function in immunoproteasome
A novel role of PSMB9 in endothelial cells and atherosclerosis: beyond its canonical function in immunoproteasome
Pohl C, Dikic I. Cellular quality control by the ubiquitin-proteasome system and autophagy. Science. 2019;366:818–22.Artic...
PBPK-PD model for predicting morphine pharmacokinetics, CNS effects and naloxone antagonism in humans
PBPK-PD model for predicting morphine pharmacokinetics, CNS effects and naloxone antagonism in humans
Morphine and morphine-6-glucuronide (M6G) produce central nervous system (CNS) effects by activating mu-opioid receptors, ...
The marine-derived compound TAG alleviates Parkinson’s disease by restoring RUBCN-mediated lipid metabolism homeostasis
The marine-derived compound TAG alleviates Parkinson’s disease by restoring RUBCN-mediated lipid metabolism homeostasis
Parkinson’s disease (PD) is the second most common neurodegenerative disease, and its prevalence is increasing. Curr...
ROCK1 inhibition improves wound healing in diabetes via RIPK4/AMPK pathway
ROCK1 inhibition improves wound healing in diabetes via RIPK4/AMPK pathway
Refractory wounds are a severe complication of diabetes mellitus that often leads to amputation because of the lack of eff...
Radiofrequency radiation reshapes tumor immune microenvironment into antitumor phenotype in pulmonary metastatic melanoma by inducing active transformation of tumor-infiltrating CD8+ T and NK cells
Radiofrequency radiation reshapes tumor immune microenvironment into antitumor phenotype in pulmonary metastatic melanoma by inducing active transformation of tumor-infiltrating CD8+ T and NK cells
Immunosuppression by the tumor microenvironment is a pivotal factor contributing to tumor progression and immunotherapy re...
Disfunction of dorsal raphe nucleus-hippocampus serotonergic-HTR3 transmission results in anxiety phenotype of Neuroplastin 65-deficient mice
Disfunction of dorsal raphe nucleus-hippocampus serotonergic-HTR3 transmission results in anxiety phenotype of Neuroplastin 65-deficient mice
Anxiety disorders are the most common psychiatric condition, but the etiology of anxiety disorders remains largely unclear...
Parkin deficiency promotes liver cancer metastasis by TMEFF1 transcription activation via TGF-β/Smad2/3 pathway
Parkin deficiency promotes liver cancer metastasis by TMEFF1 transcription activation via TGF-β/Smad2/3 pathway
Parkin (PARK2) deficiency is frequently observed in various cancers and potentially promotes tumor progression. Here, we s...
GPR41 deficiency aggravates type 1 diabetes in streptozotocin-treated mice by promoting dendritic cell maturation
GPR41 deficiency aggravates type 1 diabetes in streptozotocin-treated mice by promoting dendritic cell maturation
Disturbances in intestinal immune homeostasis predispose susceptible individuals to type 1 diabetes (T1D). G-protein-coupl...
Small-molecule caspase-1 inhibitor CZL80 terminates refractory status epilepticus via inhibition of glutamatergic transmission
Small-molecule caspase-1 inhibitor CZL80 terminates refractory status epilepticus via inhibition of glutamatergic transmission
Status epilepticus (SE), a serious and often life-threatening medical emergency, is characterized by abnormally prolonged ...
Vagus nerve stimulation as a promising neuroprotection for ischemic stroke via α7nAchR-dependent inactivation of microglial NLRP3 inflammasome
Vagus nerve stimulation as a promising neuroprotection for ischemic stroke via α7nAchR-dependent inactivation of microglial NLRP3 inflammasome
Ischemic stroke is a major cause of disability and death worldwide, and its management requires urgent attention. Previous...
Notoginsenoside R1 promotes Lgr5+ stem cell and epithelium renovation in colitis mice via activating Wnt/β-Catenin signaling
Notoginsenoside R1 promotes Lgr5+ stem cell and epithelium renovation in colitis mice via activating Wnt/β-Catenin signaling
Inflammatory bowel disease (IBD) is characterized by persistent damage to the intestinal barrier and excessive inflammatio...
Angiotensin II type-2 receptor signaling facilitates liver injury repair and regeneration via inactivation of Hippo pathway
Angiotensin II type-2 receptor signaling facilitates liver injury repair and regeneration via inactivation of Hippo pathway
The angiotensin II type 2 receptor (AT2R) is a well-established component of the renin-angiotensin system and is known to ...
Prenatal dexamethasone exposure impairs rat blood-testis barrier function and sperm quality in adult offspring via GR/KDM1B/FSTL3/TGFβ signaling
Prenatal dexamethasone exposure impairs rat blood-testis barrier function and sperm quality in adult offspring via GR/KDM1B/FSTL3/TGFβ signaling
Both epidemiological and animal studies suggest that adverse environment during pregnancy can change the offspring develop...
Clobetasol propionate, a Nrf-2 inhibitor, sensitizes human lung cancer cells to radiation-induced killing via mitochondrial ROS-dependent ferroptosis
Clobetasol propionate, a Nrf-2 inhibitor, sensitizes human lung cancer cells to radiation-induced killing via mitochondrial ROS-dependent ferroptosis
Combining radiotherapy with Nrf-2 inhibitor holds promise as a potential therapeutic strategy for radioresistant lung canc...
zDHHC20-driven S-palmitoylation of CD80 is required for its costimulatory function
zDHHC20-driven S-palmitoylation of CD80 is required for its costimulatory function
CD80 is a transmembrane glycoprotein belonging to the B7 family, which has emerged as a crucial molecule in T cell modulat...
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