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Targeting chaperone-mediated autophagy in neurodegenerative diseases: mechanisms and therapeutic potential
Targeting chaperone-mediated autophagy in neurodegenerative diseases: mechanisms and therapeutic potential
The pathological hallmarks of various neurodegenerative diseases including Parkinson’s disease and Alzheimer’s...
Smad transcription factors as mediators of 7 transmembrane G protein-coupled receptor signalling
Smad transcription factors as mediators of 7 transmembrane G protein-coupled receptor signalling
The Smad transcription factors are well known for their role at the core of transforming growth factor-β (TGF-β)...
Dependence of NPPS creates a targetable vulnerability in RAS-mutant cancers
Dependence of NPPS creates a targetable vulnerability in RAS-mutant cancers
RAS is the most frequently mutated oncoprotein for cancer driving. Understanding of RAS biology and discovery of druggable...
How improvements in US FDA regulatory process and procedures led to the drug approval for first ever treatment of a common liver disease
Metabolic-associated liver disease is a growing public health crisis, with phenotypes from fatty liver to steatohepatitis,...
Intestinal human carboxylesterase 2 (CES2) expression rescues drug metabolism and most metabolic syndrome phenotypes in global Ces2 cluster knockout mice
Intestinal human carboxylesterase 2 (CES2) expression rescues drug metabolism and most metabolic syndrome phenotypes in global Ces2 cluster knockout mice
Carboxylesterase 2 (CES2) is expressed mainly in liver and intestine, but most abundantly in intestine. It hydrolyzes carb...
Luteolin ameliorates chronic stress-induced depressive-like behaviors in mice by promoting the Arginase-1+ microglial phenotype via a PPARγ-dependent mechanism
Luteolin ameliorates chronic stress-induced depressive-like behaviors in mice by promoting the Arginase-1+ microglial phenotype via a PPARγ-dependent mechanism
Accumulating evidence shows that neuroinflammation substantially contributes to the pathology of depression, a severe psyc...
Poria cocos: traditional uses, triterpenoid components and their renoprotective pharmacology
Poria cocos: traditional uses, triterpenoid components and their renoprotective pharmacology
Poria cocos and its surface layer of Poria cocos (Schw.) Wolf (Polyporaceae), are used in traditional Chinese medicine for...
Clozapine impaired glucose-stimulated insulin secretion partly by increasing plasma 5-HT levels due to the inhibition of OCT1-mediated hepatic 5-HT uptake in mice
Clozapine impaired glucose-stimulated insulin secretion partly by increasing plasma 5-HT levels due to the inhibition of OCT1-mediated hepatic 5-HT uptake in mice
Patients taking atypical antipsychotics (AAPs), especially clozapine, are often associated with hyperglycaemia. Here, cloz...
Circulating metabolites of Borneolum syntheticum (Bingpian) ameliorate atherosclerosis in ApoE−/− mice via inhibiting macrophage foam-cell formation
Circulating metabolites of Borneolum syntheticum (Bingpian) ameliorate atherosclerosis in ApoE−/− mice via inhibiting macrophage foam-cell formation
Translational pharmacological research on traditional medicines lays the foundation for precisely understanding how the me...
VEGFD/VEGFR3 signaling contributes to the dysfunction of the astrocyte IL-3/microglia IL-3Rα cross-talk and drives neuroinflammation in mouse ischemic stroke
VEGFD/VEGFR3 signaling contributes to the dysfunction of the astrocyte IL-3/microglia IL-3Rα cross-talk and drives neuroinflammation in mouse ischemic stroke
Astrocyte-derived IL-3 activates the corresponding receptor IL-3Rα in microglia. This cross-talk between astrocytes a...
Sequential activation of ERα-AMPKα signaling by the flavonoid baicalin down-regulates viral HNF-dependent HBV replication
Sequential activation of ERα-AMPKα signaling by the flavonoid baicalin down-regulates viral HNF-dependent HBV replication
Baicalin (BA), a natural component found in many traditional Chinese medicines, exerts protective effects against several ...
Molecular and cellular mechanisms of itch sensation and the anti-itch drug targets
Molecular and cellular mechanisms of itch sensation and the anti-itch drug targets
Itch is an uncomfortable feeling that evokes a desire to scratch. This protective reflex can effectively eliminate parasit...
Longitudinal and time-to-event modeling for the survival of advanced pancreatic ductal adenocarcinoma patients
Longitudinal and time-to-event modeling for the survival of advanced pancreatic ductal adenocarcinoma patients
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers especially at advanced stage. In order to analyz...
A derivative of tanshinone IIA and salviadione, 15a, inhibits inflammation and alleviates DSS-induced colitis in mice by direct binding and inhibition of RIPK2
A derivative of tanshinone IIA and salviadione, 15a, inhibits inflammation and alleviates DSS-induced colitis in mice by direct binding and inhibition of RIPK2
Inflammatory bowel diseases (IBDs) are chronic inflammatory conditions primarily affecting the gastrointestinal tract. Pre...
Modulation of autophagy by melatonin and its receptors: implications in brain disorders
Modulation of autophagy by melatonin and its receptors: implications in brain disorders
Autophagy plays a crucial role in maintaining neuronal homeostasis and function, and its disruption is linked to various b...
A recombinant fragment antigen-binding (Fab) of trastuzumab displays low cytotoxic profile in adult human cardiomyocytes: first evidence and the key implication of FcγRIIA receptor
A recombinant fragment antigen-binding (Fab) of trastuzumab displays low cytotoxic profile in adult human cardiomyocytes: first evidence and the key implication of FcγRIIA receptor
Fragment crystallizable gamma receptors (FcγRs) mediate various cellular responses with significant cardiovascular im...
Mettl1 knockdown alleviates cardiac I/R injury in mice by inactivating the Mettl1-CYLD-P53 positive feedback loop
Mettl1 knockdown alleviates cardiac I/R injury in mice by inactivating the Mettl1-CYLD-P53 positive feedback loop
The N7-methylguanosine (m7G) methyltransferase Mettl1 has been recently implicated in cardiac repair and fibrosis. In this...
LN-439A, a novel BAP1 inhibitor, suppresses the growth of basal-like breast cancer by degrading KLF5
LN-439A, a novel BAP1 inhibitor, suppresses the growth of basal-like breast cancer by degrading KLF5
Basal-like breast cancer (BLBC) is the most malignant subtype of breast cancer because of its aggressive clinical behaviou...
A structure-based virtual screening identifies a novel MDM2 antagonist in the activation of the p53 signaling and inhibition of tumor growth
A structure-based virtual screening identifies a novel MDM2 antagonist in the activation of the p53 signaling and inhibition of tumor growth
p53, a tumor suppressor protein, has a vital role in the regulation of the cell cycle, apoptosis, and DNA damage repair. T...
19F qNMR based pharmacokinetics, metabolism and mass balance studies of SARS-CoV-2-3CL protease inhibitor simnotrelvir (SIM0417) in humans
19F qNMR based pharmacokinetics, metabolism and mass balance studies of SARS-CoV-2-3CL protease inhibitor simnotrelvir (SIM0417) in humans
Simnotrelvir (SIM0417), an inhibitor of the 3CL protease of SARS-CoV-2, has been identified as a CYP3A sensitive substrate...
Tofacitinib prevents depressive-like behaviors through decreased hippocampal microgliosis and increased BDNF levels in both LPS-induced and CSDS-induced mice
Tofacitinib prevents depressive-like behaviors through decreased hippocampal microgliosis and increased BDNF levels in both LPS-induced and CSDS-induced mice
Depressive disorders are a global mental health challenge that is closely linked to inflammation, especially in the post-C...
AI-driven antibody design with generative diffusion models: current insights and future directions
AI-driven antibody design with generative diffusion models: current insights and future directions
Therapeutic antibodies are at the forefront of biotherapeutics, valued for their high target specificity and binding affin...
β-arrestin2: an emerging player and potential therapeutic target in inflammatory immune diseases
β-arrestin2: an emerging player and potential therapeutic target in inflammatory immune diseases
β-arrestin2, a pivotal protein within the arrestin family, is localized in the cytoplasm, plasma membrane and nucleus...
Adaptor protein Src-homology 2 domain containing E (SH2E) deficiency induces heart defect in zebrafish
Adaptor protein Src-homology 2 domain containing E (SH2E) deficiency induces heart defect in zebrafish
Adaptor proteins play crucial roles in signal transduction across diverse signaling pathways. Src-homology 2 domain-contai...
Oral administration of astilbin mitigates acetaminophen-induced acute liver injury in mice by modulating the gut microbiota
Oral administration of astilbin mitigates acetaminophen-induced acute liver injury in mice by modulating the gut microbiota
Acetaminophen (APAP) overdose-induced acute liver injury (ALI) is characterized by extensive oxidative stress, and the cli...
Activation of D2-like dopamine receptors improves the neuronal network and cognitive function of PPT1KI mice
Activation of D2-like dopamine receptors improves the neuronal network and cognitive function of PPT1KI mice
Palmitoyl-protein thioesterase 1 (PPT1) is a lysosomal depalmitoylation enzyme that mediates protein posttranslational mod...
Baicalein ameliorates chronic itch in ACD mice by suppressing the spinal astrocytic STAT3–LCN2 cascade
Baicalein ameliorates chronic itch in ACD mice by suppressing the spinal astrocytic STAT3–LCN2 cascade
Chronic itch is a maladaptive and debilitating symptom in patients with allergic contact dermatitis (ACD), adversely affec...
G3BP2 promotes tumor progression and gemcitabine resistance in PDAC via regulating PDIA3-DKC1-hENT in a stress granules-dependent manner
G3BP2 promotes tumor progression and gemcitabine resistance in PDAC via regulating PDIA3-DKC1-hENT in a stress granules-dependent manner
Pancreatic ductal adenocarcinoma (PDAC) is distinguished by its aggressive malignancy, limited treatment avenues and a ten...
SGLT2 inhibitors ameliorate NAFLD in mice via downregulating PFKFB3, suppressing glycolysis and modulating macrophage polarization
SGLT2 inhibitors ameliorate NAFLD in mice via downregulating PFKFB3, suppressing glycolysis and modulating macrophage polarization
Sodium-glucose co-transporter 2 (SGLT2) inhibitor (SGLT2i) is a novel class of anti-diabetic drug, which has displayed a p...
Bile duct ligation impairs visual acuity in rats by ammonia- and bilirubin-induced retinal degeneration
Bile duct ligation impairs visual acuity in rats by ammonia- and bilirubin-induced retinal degeneration
Patients with hepatic failure are often accompanied by hepatic retinopathy, but the cellular and molecular mechanisms unde...
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