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Sci. Pharm., Vol. 90, Pages 72: Uptake of Cationic PAMAM-PLGA Nanoparticles by the Nasal Mucosa
Nanoparticles provide promising advantages in advanced delivery systems for enhanced drug delivery and targeting. The use ...
Sci. Pharm., Vol. 90, Pages 73: Effect of Aqueous Extracts of Quercus resinosa on the Mechanical Behavior of Bigels
Quercus resinosa leaves are rich in polyphenol compounds, however, they are unstable to several chemical and physical fact...
Sci. Pharm., Vol. 90, Pages 66: Orally Administered Prosochit®-Based Nanoparticles of Insulin Ameliorates Alloxan-Induced Diabetes in Rats
This work was aimed to assess the antidiabetic effect of orally administered Prosochit®-based nanoparticles of ins...
Sci. Pharm., Vol. 90, Pages 71: Enhancement of the Solubility and Dissolution Rate of Telmisartan by Surface Solid Dispersions Employing Superdisintegrants, Hydrophilic Polymers and Combined Carriers
Telmisartan (Tel) is a potent antihypertensive drug with a very poor aqueous solubility, especially in pH ranging from 3 t...
Sci. Pharm., Vol. 90, Pages 70: Anti-Sporotrichotic Activity, Lambert-W Inhibition Kinetics and 3D Structural Characterization of Sporothrix schenckii Catalase as Target of Glucosinolates from Moringa oleifera
Most human fungal infections exhibit significant defensive oxidative stress responses, which contribute to their pathogeni...
Sci. Pharm., Vol. 90, Pages 62: Production of Bovine Collagen Hydrolysate with Antioxidant Activity; Optimized by Response Surface Methodology
Antioxidants are widely used in pharmaceutical industries. Gelatin is a byproduct of the meat industry and its hydrolysate...
Sci. Pharm., Vol. 90, Pages 65: Concepts for a New Rapid and Simple HPLC Method for Simultaneous Determination of Metoprolol and Meldonium in Pharmaceutical Dosage Forms
Simultaneous determination of the tandem of drugs, like meldonium and metoprolol, with enormous polarity differences betwe...
Sci. Pharm., Vol. 90, Pages 67: Modification of Taxifolin Properties by Spray Drying
Taxifolin is known as an active pharmaceutical ingredient (API) and food supplement due to its high antioxidant activity, ...
Sci. Pharm., Vol. 90, Pages 69: Ethanolic Extract of Ocimum sanctum Linn. Inhibits Cell Migration of Human Lung Adenocarcinoma Cells (A549) by Downregulation of Integrin αvβ3, α5β1, and VEGF
Adenocarcinoma lung cancer is a type of non-small cell lung carcinoma (NSCLC), which accounts for 85% of lung cancer incid...
Sci. Pharm., Vol. 90, Pages 59: Potential and Alternative Bioactive Compounds from Brown Agaricus bisporus Mushroom Extracts for Xerosis Treatment
This study aimed to investigate the ability of brown Agaricus bisporus extracts to enhance xerosis treatment via their bio...
Sci. Pharm., Vol. 90, Pages 60: Green Synthesis of Silver Nanoparticles Using Bellevalia Flexuosa Leaves Extract
Silver nanoparticles (AgNPs) have broad biocidal activities, and are widely employed as an active ingredient in antiseptic...
Sci. Pharm., Vol. 90, Pages 63: Synthesis and Anticholinesterase Evaluation of Cassine, Spectaline and Analogues
In this work, twelve analogues of piperidine alkaloids (-)-cassine and (-)-spectaline were synthesized, as well as the rac...
Sci. Pharm., Vol. 90, Pages 68: Fabrication of Hydroxypropyl Methylcellulose Orodispersible Film Loaded Mirtazapine Using a Syringe Extrusion 3D Printer
Depression is a mental illness causing a continuous negative feeling and loss of interest and affects physical and mental ...
Sci. Pharm., Vol. 90, Pages 64: GC-MS Analysis of the Phytochemical Constituents, Safety Assessment, Wound Healing and Anti-Inflammatory Activities of Cucurbita pepo Leaf Extract in Rats
In traditional medicine, Cucurbita pepo L. is used for the treatment of rheumatism, diabetes, inflammations, and wound inj...
Sci. Pharm., Vol. 90, Pages 61: The Effect of Zinc Oxide Nanoparticles on Properties and Burn Wound Healing Activity of Thixotropic Xymedone Gels
Zinc oxide nanoparticles (ZnO NPs) modified by oxopyrymidine alcohol, also known as xymedone (Xym), were obtained and stud...
Sci. Pharm., Vol. 90, Pages 57: A Narrative Review on the Bioactivity and Health Benefits of Alpha-Phellandrene
Aromatic essential oils play a significant role in pharmaceuticals, food additives, cosmetics, and perfumery. Essential oi...
Sci. Pharm., Vol. 90, Pages 56: Evaluation of 5-[(Z)-(4-nitrobenzylidene)]-2-(thiazol-2-ylimino)-4-thiazolidinone (Les-6222) as Potential Anticonvulsant Agent
It was determined that the studied 5-[(Z)-(4-nitrobenzylidene)]-2-(thiazol-2-ylimino)-4-thiazolidinone (Les-6222) affects ...
Sci. Pharm., Vol. 90, Pages 55: LC-HRMS-Based Profiling: Antibacterial and Lipase Inhibitory Activities of Some Medicinal Plants for the Remedy of Obesity
Globally, obesity is a serious health concern that causes numerous diseases, including type 2 diabetes, hypertension, card...
Sci. Pharm., Vol. 90, Pages 54: Molecularly-Imprinted SERS: A Potential Method for Bioanalysis
The most challenging step in developing bioanalytical methods is finding the best sample preparation method. The matrix in...
Sci. Pharm., Vol. 90, Pages 52: New Quinazolin-4(3H)-one Derivatives Incorporating Hydrazone and Pyrazole Scaffolds as Antimicrobial Agents Targeting DNA Gyraze Enzyme
The present work includes the synthesis of a new series of quinazolin-4(3H)-one compounds (4a–f, 5a–d)...
Sci. Pharm., Vol. 90, Pages 53: Development of HPLC Method for Simultaneous Determination of Ibuprofen and Chlorpheniramine Maleate
One of the most prevalent over-the-counter cold and cough medications is the chlorpheniramine maleate (CPM)–ibup...
Sci. Pharm., Vol. 90, Pages 50: Antidepressant Effect of Neuropeptide Y in Models of Acute and Chronic Stress
The search for potential effective antidepressants with minimal side effects is necessary. Peptides are possible applicant...
Sci. Pharm., Vol. 90, Pages 51: Melt Fusion Techniques for Solubility Enhancement: A Comparison of Hot Melt Extrusion and KinetiSol® Technologies
A successful candidate for oral drug delivery needs to possess adequate solubility and dissolution rate to elicit its ther...
Sci. Pharm., Vol. 90, Pages 49: Effects of Origanum vulgare and Scutellaria baicalensis on the Physiological Activity and Biochemical Parameters of the Blood in Rats on a High-Fat Diet
The pharmacological effects of medicinal plants play a primary role in the mild correction of body weight in humans and an...
Sci. Pharm., Vol. 90, Pages 47: 2D-QSAR and CoMFA Models for Antitubercular Activity of Scalarane-Type Sesterterpenes
A series of scalarane sesterterpenes were prepared using heteronemin (1) as a primary precursor. Combined with the scalara...
Sci. Pharm., Vol. 90, Pages 48: Uncovering Streptomyces-Derived Compounds as Cosmeceuticals for the Development of Improved Skin Photoprotection Products: An In Silico Approach to Explore Multi-Targeted Agents
The search for novel photoprotective substances has become a challenge in cosmeceutical research. Streptomyces-derived com...
Sci. Pharm., Vol. 90, Pages 46: Synthesis and Evaluation of (1,4-Disubstituted)-1,2,3-triazoles as Estrogen Receptor Beta Agonists
Estrogen receptors (ER) are nuclear hormone receptors which are responsible for sex hormone signaling in women. A series o...
Sci. Pharm., Vol. 90, Pages 45: Apoptosis Induction Associated with Enhanced ER Stress Response and Up-Regulation of c-Jun/p38 MAPK Proteins in Human Cervical Cancer Cells by Colocasia esculenta var. aquatilis Hassk Extract
Colocasia esculenta var. Aquatilis Hassk, elephant ear (CF-EE) has been widely used as traditional food and medicine. It a...
Sci. Pharm., Vol. 90, Pages 44: Ruellia tuberosa Ethyl Acetate Leaf Extract Induces Apoptosis and Cell Cycle Arrest in Human Breast Cancer Cell Line, MCF-7
Ruellia tuberosa L. has been previously shown to possess antioxidant and antiproliferative activities on cancer cells but ...
Sci. Pharm., Vol. 90, Pages 43: Bimodal Release Two-In-One Clonazepam Matrix Lozenge Tablets for Managing Anxiety-Related Disorders: Formulation, Optimization and In Vivo Evaluation
Clonazepam (CLZ), an antipsychotic drug reported for its efficiency in managing anxiety-related disorders, is being market...
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