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Recent advances in label-free imaging and quantification techniques for the study of lipid droplets in cells
Recent advances in label-free imaging and quantification techniques for the study of lipid droplets in cells
As subcellular organelles, lipid droplets (LDs) consist of a hydrophobic core of neutral lipids such as triacylglycerols (...
Neurofilaments: Novel findings and future challenges
Neurofilaments: Novel findings and future challenges
Neurofilaments (NFs) are abundant cytoskeletal proteins that emerge as a critical hub for cell signalling within neurons. ...
GFAP-isoforms in the nervous system: Understanding the need for diversity
GFAP-isoforms in the nervous system: Understanding the need for diversity
Glial fibrillary acidic protein (GFAP) is an intermediate filament (IF) protein expressed in specific types of glial cells...
Editorial overview: Functional specialization of the cytoskeleton in diverse cell types
Editorial overview: Functional specialization of the cytoskeleton in diverse cell types
Adele Marston is professor of cell biology at the University of Edinburgh, a wellcome investigator and director of the Dis...
Cytoskeletal crosstalk: A focus on intermediate filaments
Cytoskeletal crosstalk: A focus on intermediate filaments
The cytoskeleton, comprising actin microfilaments, microtubules, and intermediate filaments, is crucial for cell motility ...
Nuclear mechanotransduction on skin stem cell fate regulation
Nuclear mechanotransduction on skin stem cell fate regulation
Mechanical signals have critical roles in regulating cellular function at the level of single cells, as well as in coordin...
Cell competition and the regulation of protein homeostasis
Cell competition and the regulation of protein homeostasis
The process of embryonic development involves remarkable cellular plasticity, which governs the coordination between cells...
Mechanotransduction through protein stretching
Mechanotransduction through protein stretching
Cells sense and respond to subtle changes in their physicality, and via a myriad of different mechanosensitive processes, ...
Forced back into shape: Mechanics of epithelial wound repair
Forced back into shape: Mechanics of epithelial wound repair
Wound repair, the closing of a hole, is inherently a physical process that requires the change of shape of materials, in t...
All the small things: Nanoscale matrix alterations in aging tissues
All the small things: Nanoscale matrix alterations in aging tissues
Cellular aging stems from multifaceted intra- and extracellular molecular changes that lead to the gradual deterioration o...
Lamins: The backbone of the nucleocytoskeleton interface
Lamins: The backbone of the nucleocytoskeleton interface
The nuclear lamina (NL) underlies the inner nuclear membrane (INM) and consists of lamin filaments and associated proteins...
Decoding the cell nucleus
Decoding the cell nucleus
Dr. Lakadamyali obtained her BS in Physics from the University of Texas at Austin in 2001 and PhD in Physics from Harvard ...
Scaling the cellular frontier: Mechanobiology, tissue dynamics and function
Scaling the cellular frontier: Mechanobiology, tissue dynamics and function
Giorgio Scita is professor of Pathology at the University of Milan and Principal Investigator at IFOM ETS - The AIRC Insti...
Recent developments in membrane traffic and lipid dynamics
Recent developments in membrane traffic and lipid dynamics
Aurélien Roux designs his research at the interface between biology, chemistry, and physics. He developed in vitro reconst...
Cellular stress management by caspases
Cellular stress management by caspases
Cellular stress plays a pivotal role in the onset of numerous human diseases. Consequently, the removal of dysfunctional c...
Engineering physiological environments to advance kidney organoid models from human pluripotent stem cells
Engineering physiological environments to advance kidney organoid models from human pluripotent stem cells
During embryogenesis, the mammalian kidney arises because of reciprocal interactions between the ureteric bud (UB) and the...
Staying away from the breaking point: Probing the limits of epithelial cell elimination
Staying away from the breaking point: Probing the limits of epithelial cell elimination
Epithelial tissues are dramatically remodelled during embryogenesis and tissue homeostasis and yet need to maintain their ...
Jagged-mediated development and disease: Mechanistic insights and therapeutic implications for Alagille syndrome
Jagged-mediated development and disease: Mechanistic insights and therapeutic implications for Alagille syndrome
Volume 86, February 2024, 102302Author links open overlay panel, AbstractNotch signaling controls multiple aspects of embr...
Extracellular matrix dynamics: A key regulator of cell migration across length-scales and systems
Extracellular matrix dynamics: A key regulator of cell migration across length-scales and systems
The extracellular matrix (ECM) is a complex 3-dimensional (3D) meshwork of proteins that provides structural support to ce...
Creative processes during vertebrate organ morphogenesis: Biophysical self-organization at the supracellular scale
Creative processes during vertebrate organ morphogenesis: Biophysical self-organization at the supracellular scale
Volume 86, February 2024, 102305Author links open overlay panel, , AbstractHere, we review recent developments in the lite...
Pulling the strings on solid-to-liquid phase transitions in cell collectives
Pulling the strings on solid-to-liquid phase transitions in cell collectives
The physical state of a tissue emerges from local interactions between its constituent cells. Recent years have brought im...
Mechanobiology of myeloid cells
Mechanobiology of myeloid cells
Mechanobiology is an established research field devoted to understanding how cells sense and respond to mechanical signals...
Cellular spartans at the pass: Emerging intricacies of cell competition in early and late tumorigenesis
Cellular spartans at the pass: Emerging intricacies of cell competition in early and late tumorigenesis
Cell competition is a mechanism for cellular quality control based on cell–cell comparisons of fitness. Recent studies hav...
Vimentin cage – A double-edged sword in host anti-infection defense
Vimentin cage – A double-edged sword in host anti-infection defense
Vimentin, a type III intermediate filament protein, plays a crucial role in maintaining the structural integrity and mecha...
Lipid nanodomains and receptor signaling: From actin-based organization to membrane mechanics
Lipid nanodomains and receptor signaling: From actin-based organization to membrane mechanics
Volume 86, February 2024, 102308Author links open overlay panel, , , AbstractThe plasma membrane serves as the primary bar...
Astrocyte signaling and interactions in Multiple Sclerosis
Astrocyte signaling and interactions in Multiple Sclerosis
Multiple Sclerosis (MS) is a common cause of impairment in working-aged adults. MS is characterized by neuroinflammation a...
Nuclear roles for non-lamin intermediate filament proteins
Nuclear roles for non-lamin intermediate filament proteins
Volume 86, February 2024, 102303Author links open overlay panel, , , AbstractThe nuclear-localized lamins have long been t...
Regulation of protein synthesis and stability by mechanical cues and its implications in cancer
Regulation of protein synthesis and stability by mechanical cues and its implications in cancer
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Mechanotransduction through membrane tension: It's all about propagation?
Mechanotransduction through membrane tension: It's all about propagation?
The cell membranes are primarily composed of two layers of amphipathic lipids arranged with their hydrophobic tails facing...
Organelle morphology and positioning orchestrate physiological and disease-associated processes
Organelle morphology and positioning orchestrate physiological and disease-associated processes
To preserve cell homeostasis, subcellular compartments are tightly regulated in size, shape, and number, and their activit...