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Genome-wide tracing to decipher nuclear organization
The invention of Hi-C [1] more than a decade ago has drastically changed the field of genome organization. Through the gen...
New insights into the OSBP‒VAP cycle
In eukaryotic cells, the membranes of each organelle have a unique lipid composition, which is adapted to their functions ...
Dynamins in human diseases: differential requirement of dynamin activity in distinct tissues
Volume 81, April 2023, 102174Author links open overlay panel, , AbstractDynamin, a 100-kDa GTPase, is one of the most-char...
Methods for mapping 3D-chromosome architecture around nucleoli
The nucleolus is the largest subcompartment of the nucleus, known to be the place of ribosome biogenesis. Emerging evidenc...
Exploring membrane mechanics: The role of membrane-cortex attachment in cell dynamics
In recent years, there has been growing interest in the role of plasma membrane (PM) tension in cell dynamics. Individual ...
Physiological and regulatory convergence between osmotic and nutrient stress responses in microbes
Osmolarity, the number of dissolved solute particles per liter of solution, is an important yet often ignored aspect of ce...
Receptors, enzymes and self-attraction as autocrine generators and amplifiers of chemotaxis and cell steering
Cells create their own steering cues, or modify cues from their outside, for a number of reasons. These include generating...
Who's really in charge: Diverse follower cell behaviors in collective cell migration
Collective cell migrations drive morphogenesis, wound healing, and cancer dissemination. Cells located at the front are co...
Discretizing the cellular bases of plant morphogenesis: Emerging properties from subcellular and noisy patterning
Tissue morphogenesis is first and foremost a question of geometry. The organ shapes produced in the natural world are simu...
The many faces of the bouquet centrosome MTOC in meiosis and germ cell development
Meiotic chromosomal pairing is facilitated by a conserved cytoskeletal organization. Telomeres associate with perinuclear ...
From WRC to Arp2/3: Collective molecular mechanisms of branched actin network assembly
Progress in targeted loss-of-function genetics (most recently by CRISPR/Cas-mediated genome editing) continues to generate...
Cellularization across eukaryotes: Conserved mechanisms and novel strategies
Many eukaryotes form multinucleated cells during their development. Some cells persist as such during their lifetime, othe...
Endosome biogenesis is controlled by ER and the cytoskeleton at tripartite junctions
The endocytic system consists of many independently trafficking vesicles called endosomes, which facilitate cargo flow fro...
Building the brush border, one microvillus at a time
Volume 80, February 2023, 102153Author links open overlay panel, , AbstractMicrovilli are actin bundle-supported surface p...
Cadherins and the cortex: A matter of time?
It is often difficult to understand how cell adhesion systems work without considering their engagement with the actomyosi...
The compass to follow: Focal adhesion turnover
How cells move is a fundamental biological question. The directionality of adherent migrating cells depends on the assembl...
Molecular and cellular constraints on vesicle traffic evolution
In eukaryotic cells, the budding and fusion of intracellular transport vesicles is carefully orchestrated in space and tim...
Mitochondrial movers and shapers: Recent insights into regulators of fission, fusion and transport
Volume 80, February 2023, 102150Author links open overlay panelAbstractMitochondria are highly dynamic organelles that und...
Engineering metaphase spindles: Construction site and building blocks
Volume 79, December 2022, 102143Author links open overlay panelAbstractIn an active, crowded cytoplasm, eukaryotic cells c...
Highly conserved, but highly specific: Somatic cell–cell fusion in filamentous fungi
The development of ascomycete fungal colonies involves cell–cell fusion at different growth stages. In the model fungus Ne...
Emergence of neuron types
Neuron types are the building blocks of the nervous system, and therefore, of functional circuits. Understanding the origi...
Myosin motors in sensory hair bundle assembly
Volume 79, December 2022, 102132AbstractMechanosensory hair bundles are assembled from actin-based stereocilia that projec...
Outside Back Cover
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Manipulation of epithelial cell architecture by the bacterial pathogens Listeria and Shigella
Volume 79, December 2022, 102131AbstractSubversion of the host cell cytoskeleton is a virulence attribute common to many b...
Signaling oscillations: Molecular mechanisms and functional roles
Volume 78, October 2022, 102130AbstractMounting evidence shows that oscillatory activity is widespread in cell signaling. ...
The role of spatiotemporal organization and dynamics of clock complexes in circadian regulation
Volume 78, October 2022, 102129AbstractCircadian clocks are cell autonomous timekeepers that regulate ∼24-h oscillations i...
Editorial overview: Membranes in perpetual motion
Benjamin Glick is a Professor of Molecular Genetics and Cell Biology at the University of Chicago. His laboratory studies ...
Transport-dependent maturation of organelles in neurons
Volume 78, October 2022, 102121Highlights•Several organelles spatially segregate and form a maturation gradient along the ...
Editorial: Emerging concepts and tools in genome organization and chromatin function in eukaryotes
Kazuhiro Maeshima obtained his Ph.D. from the Osaka University in Japan on the biochemical and biophysical analyses of pro...
ER and Golgi trafficking in axons, dendrites, and glial processes
Volume 78, October 2022, 102119AbstractBoth neurons and glia in mammalian brains are highly ramified. Neurons form complex...
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