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The ICOS‐ICOSL pathway tunes thymic selection
The ICOS‐ICOSL pathway tunes thymic selection
Abstract Negative selection of developing T cells plays a significant role in T cell tolerance to self-antigen. This proce...
ILC2‐derived IL‐13 promotes skin cDC2 diversity
ILC2‐derived IL‐13 promotes skin cDC2 diversity
In a new study, researchers have identified a new population of type 2 conventional dendritic cells in the skin that depen...
Differential antigenic requirements by diverse MR1‐restricted T cells
Differential antigenic requirements by diverse MR1‐restricted T cells
Abstract MHC-related protein 1 (MR1) presents microbial riboflavin metabolites to mucosal-associated invariant T (MAIT) ce...
Immunology & Cell Biology's top 10 original research articles 2020–2021
Immunology & Cell Biology's top 10 original research articles 2020–2021
While the start of the new year is filled with the promise of the year to come, it is also a fine time to reflect on achie...
Unleashing T cell responses to cancer through removal of intracellular checkpoints
Unleashing T cell responses to cancer through removal of intracellular checkpoints
In a new study, researchers identified protein tyrosine phosphatase PTP1B as an inhibitor of cytokine receptor signalling ...
Expression of the miR‐17~92a cluster of microRNAs by regulatory T cells controls blood glucose homeostasis
Expression of the miR‐17~92a cluster of microRNAs by regulatory T cells controls blood glucose homeostasis
ABSTRACT Regulatory T cells (Tregs) are a specialised immune cell type that plays important roles in regulating immune res...
The benefit of boosters: diversity and inclusion in the COVID‐19 memory response
The benefit of boosters: diversity and inclusion in the COVID‐19 memory response
In a new study, a group evaluate immune responses against SARS-CoV-2 in vaccinated individuals and find evidence of durabl...
Iron excess affects release of neutrophil extracellular traps and reactive oxygen species but does not influence other functions of neutrophils
Iron excess affects release of neutrophil extracellular traps and reactive oxygen species but does not influence other functions of neutrophils
Abstract Neutrophils apply several antimicrobial strategies including degranulation, phagocytosis, the generation of react...
Metabolic reprogramming of macrophages instigates CCL21‐induced arthritis
Metabolic reprogramming of macrophages instigates CCL21‐induced arthritis
ABSTRACT The current study was designed to delineate the functional significance of CCL21 on metabolic reprogramming in ex...
The Australasian Cell Death Society (ACDS): celebrating 50 years of Australasian cell death research
The Australasian Cell Death Society (ACDS): celebrating 50 years of Australasian cell death research
Australasian researchers, including those from Australia and New Zealand, have a rich history of medical innovation which ...
Combination of N, N'‐dicyclohexyl‐N‐arachidonic acylurea and tacrolimus prolongs cardiac allograft survival in mice
Combination of N, N'‐dicyclohexyl‐N‐arachidonic acylurea and tacrolimus prolongs cardiac allograft survival in mice
Immunology & Cell Biology 2021; https://doi.org/10.1111/imcb.12507 Correction to: Immunol Cell Biol...
Iron excess affects release of NETs and ROS but does not influence other functions of neutrophils
Iron excess affects release of NETs and ROS but does not influence other functions of neutrophils
Abstract Neutrophils apply several antimicrobial strategies including degranulation, phagocytosis, the generation of react...
Comprehensive immune cell profiling depicts an early immune response associated with severe coronavirus disease 2019 in cancer patients
Comprehensive immune cell profiling depicts an early immune response associated with severe coronavirus disease 2019 in cancer patients
Abstract Recent studies have highlighted multiple immune perturbations related to severe acute respiratory syndrome corona...
Poor protective potential of influenza nucleoprotein antibodies despite wide prevalence
Poor protective potential of influenza nucleoprotein antibodies despite wide prevalence
Abstract Humans are exposed to influenza virus through periodic infections. Due to these repeated exposures, human populat...
Tolerance induction by liposomes targeting a single CD8 epitope IGRP206‐214 in a model of type 1 diabetes is impeded by co‐targeting a CD4 islet epitope
Tolerance induction by liposomes targeting a single CD8 epitope IGRP206‐214 in a model of type 1 diabetes is impeded by co‐targeting a CD4 islet epitope
Abstract The autoimmune disease, type 1 diabetes, is predominantly mediated by CD8+ cytotoxic T cell destruction of islet ...
Vaccine‐induced immune thrombosis and thrombocytopenia syndrome following adenovirus‐vectored severe acute respiratory syndrome coronavirus 2 vaccination: a novel hypothesis regarding mechanisms and implications for future vaccine development
Vaccine‐induced immune thrombosis and thrombocytopenia syndrome following adenovirus‐vectored severe acute respiratory syndrome coronavirus 2 vaccination: a novel hypothesis regarding mechanisms and implications for future vaccine development
Abstract We hypothesize that thrombosis with thrombocytopenia syndrome recently described after administration of adenovir...
Rab6b localizes to the Golgi complex in murine macrophages and promotes tumor necrosis factor release in response to mycobacterial infection
Rab6b localizes to the Golgi complex in murine macrophages and promotes tumor necrosis factor release in response to mycobacterial infection
Abstract The proinflammatory cytokine tumor necrosis factor (TNF) plays a central role in the host control of mycobacteria...
Neuroimmune interactions at the crossroads of health and disease
Neuroimmune interactions at the crossroads of health and disease
Interactions between cells of the immune system and the nervous system play critical roles in tissue homeostasis and prote...
Comprehensive immune cell profiling depicts an early immune response associated with severe COVID‐19 disease in cancer patients
Comprehensive immune cell profiling depicts an early immune response associated with severe COVID‐19 disease in cancer patients
ABSTRACT Recent studies have highlighted multiple immune perturbations related to SARS-CoV-2 infection-associated respirat...
Immunology & Cell Biology Publication of the Year Awards 2020
Immunology & Cell Biology Publication of the Year Awards 2020
The Immunology & Cell Biology Publication of the Year Awards have been established for outstanding studies submitted b...
Rab6b localizes to the Golgi complex in murine macrophages and promotes TNF release in response to mycobacterial infection
Rab6b localizes to the Golgi complex in murine macrophages and promotes TNF release in response to mycobacterial infection
ABSTRACT The pro-inflammatory cytokine TNF plays a central role in the host control of mycobacterial infections. Expressio...
Tumor reactivity of CD8+ T cells favors acquisition of dysfunctional states in human melanoma
Tumor reactivity of CD8+ T cells favors acquisition of dysfunctional states in human melanoma
A recent study by Oliveira et al. provides, in unprecedented detail, novel insights into the relationship between tum...
Helicase antigen (HAGE)‐derived vaccines induce immunity to HAGE and ImmunoBody®‐HAGE DNA vaccine delays the growth and metastasis of HAGE‐expressing tumors in vivo
Helicase antigen (HAGE)‐derived vaccines induce immunity to HAGE and ImmunoBody®‐HAGE DNA vaccine delays the growth and metastasis of HAGE‐expressing tumors in vivo
Abstract The management of patients with triple-negative breast cancer (TNBC) continues to pose a significant clinical cha...
Tetraspanin CD53 modulates lymphocyte trafficking but not systemic autoimmunity in Lyn‐deficient mice
Tetraspanin CD53 modulates lymphocyte trafficking but not systemic autoimmunity in Lyn‐deficient mice
Abstract The leukocyte-restricted tetraspanin CD53 has been shown to promote lymphocyte homing to lymph nodes and myeloid ...
Streptolysins are the primary inflammasome activators in macrophages during Streptococcus pyogenes infection
Streptolysins are the primary inflammasome activators in macrophages during Streptococcus pyogenes infection
Abstract Group A Streptococcus (GAS) is a Gram-positive bacterial pathogen that causes an array of infectious diseases in ...
Impact of Type 2 Diabetes on the capacity of human macrophages infected with Mycobacterium tuberculosis to modulate monocyte differentiation through a bystander effect
Impact of Type 2 Diabetes on the capacity of human macrophages infected with Mycobacterium tuberculosis to modulate monocyte differentiation through a bystander effect
ABSTRACT Type 2 diabetes mellitus (T2DM) is a risk factor for the development of tuberculosis (TB) through mechanisms poor...
Walking down the memory lane with SARS‐CoV‐2 B cells
Walking down the memory lane with SARS‐CoV‐2 B cells
The B-cell response to COVID-19 vaccines in convalescent individuals.
A preliminary investigation into the immune cell landscape of schistosome‐associated liver fibrosis in humans
A preliminary investigation into the immune cell landscape of schistosome‐associated liver fibrosis in humans
Abstract Schistosomiasis is a widespread helminth disease that poses a heavy social and economic burden on people worldwid...
Neuroimmunology of cancer and associated symptomology
Neuroimmunology of cancer and associated symptomology
Abstract Evolutionarily the nervous system and immune cells have evolved to communicate with each other to control inflamm...
Neutralizing type‐I interferon autoantibodies are associated with delayed viral clearance and intensive care unit admission in patients with COVID‐19
Neutralizing type‐I interferon autoantibodies are associated with delayed viral clearance and intensive care unit admission in patients with COVID‐19
Abstract Type-I interferons (IFNs) mediate antiviral activity and have emerged as important immune mediators during corona...
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