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USP32 facilitates non-small cell lung cancer progression via deubiquitinating BAG3 and activating RAF-MEK-ERK signaling pathway
USP32 facilitates non-small cell lung cancer progression via deubiquitinating BAG3 and activating RAF-MEK-ERK signaling pathway
The regulatory significance of ubiquitin-specific peptidase 32 (USP32) in tumor is significant, nevertheless, the biologic...
Involvement of Kindlin-1 in cutaneous squamous cell carcinoma
Involvement of Kindlin-1 in cutaneous squamous cell carcinoma
Kindler syndrome (KS) is a rare genodermatosis resulting from loss-of-function mutations in FERMT1, the gene that encodes ...
Gemcitabine as chemotherapy of head and neck cancer in Fanconi anemia patients
Gemcitabine as chemotherapy of head and neck cancer in Fanconi anemia patients
Fanconi anemia (FA) is a rare hereditary disease resulting from an inactivating mutation in the FA/BRCA pathway, critical ...
YAP/TAZ interacts with RBM39 to confer resistance against indisulam
YAP/TAZ interacts with RBM39 to confer resistance against indisulam
The Hippo pathway and its downstream effectors, Yes-associated protein/transcriptional coactivator with PDZ-binding motif ...
USP21-mediated G3BP1 stabilization accelerates proliferation and metastasis of esophageal squamous cell carcinoma via activating Wnt/β-Catenin signaling
USP21-mediated G3BP1 stabilization accelerates proliferation and metastasis of esophageal squamous cell carcinoma via activating Wnt/β-Catenin signaling
Lacking effective therapeutic targets heavily restricts the improvement of clinical prognosis for patients diagnosed with ...
Activated platelet-derived exosomal LRG1 promotes multiple myeloma cell growth
Activated platelet-derived exosomal LRG1 promotes multiple myeloma cell growth
The hypercoagulable state is a hallmark for patients with multiple myeloma (MM) and is associated with disease progression...
Comprehensive multi-omics analysis of breast cancer reveals distinct long-term prognostic subtypes
Comprehensive multi-omics analysis of breast cancer reveals distinct long-term prognostic subtypes
Breast cancer (BC) is a leading cause of cancer-related death worldwide. The diverse nature and heterogeneous biology of B...
DAB2IP inhibits glucose uptake by modulating HIF-1α ubiquitination under hypoxia in breast cancer
DAB2IP inhibits glucose uptake by modulating HIF-1α ubiquitination under hypoxia in breast cancer
Metabolic reprogramming has become increasingly important in tumor biology research. The glucose metabolic pathway is a ma...
Retraction Note: Platelet-derived growth factor receptor-α and -β promote cancer stem cell phenotypes in sarcomas
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Retraction Note: PI3K/Akt pathway and Nanog maintain cancer stem cells in sarcomas
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Mitotic MTH1 inhibitor TH1579 induces PD-L1 expression and inflammatory response through the cGAS-STING pathway
Mitotic MTH1 inhibitor TH1579 induces PD-L1 expression and inflammatory response through the cGAS-STING pathway
The mitotic MTH1 inhibitor TH1579 is a dual inhibitor that inhibits mitosis and incorporation of oxidative DNA damage and ...
An E3 ligase TRIM1 promotes colorectal cancer progression via K63-linked ubiquitination and activation of HIF1α
An E3 ligase TRIM1 promotes colorectal cancer progression via K63-linked ubiquitination and activation of HIF1α
Accumulating studies have shown that E3 ligases play crucial roles in regulating cellular biological processes and signali...
NAC1 transcriptional activation of LDHA induces hepatitis B virus immune evasion leading to cirrhosis and hepatocellular carcinoma development
NAC1 transcriptional activation of LDHA induces hepatitis B virus immune evasion leading to cirrhosis and hepatocellular carcinoma development
Our study aimed to elucidate the molecular mechanisms underlying NAC1 (nucleus accumbens associated 1) transcriptional reg...
Phenotyping of cancer-associated somatic mutations in the BCL2 transmembrane domain
Phenotyping of cancer-associated somatic mutations in the BCL2 transmembrane domain
The BCL2 family of proteins controls cell death by modulating the permeabilization of the mitochondrial outer membrane thr...
Acidovorax temperans skews neutrophil maturation and polarizes Th17 cells to promote lung adenocarcinoma development
Acidovorax temperans skews neutrophil maturation and polarizes Th17 cells to promote lung adenocarcinoma development
Change within the intratumoral microbiome is a common feature in lung and other cancers and may influence inflammation and...
RIOK3 sustains colorectal cancer cell survival under glucose deprivation via an HSP90α-dependent pathway
RIOK3 sustains colorectal cancer cell survival under glucose deprivation via an HSP90α-dependent pathway
Glucose oxidation via the pentose phosphate pathway serves as the primary cellular mechanism for generating nicotinamide a...
Progesterone receptor potentiates macropinocytosis through CDC42 in pancreatic ductal adenocarcinoma
Progesterone receptor potentiates macropinocytosis through CDC42 in pancreatic ductal adenocarcinoma
Endocrine receptors play an essential role in tumor metabolic reprogramming and represent a promising therapeutic avenue i...
Designing patient-oriented combination therapies for acute myeloid leukemia based on efficacy/toxicity integration and bipartite network modeling
Designing patient-oriented combination therapies for acute myeloid leukemia based on efficacy/toxicity integration and bipartite network modeling
Acute myeloid leukemia (AML), a heterogeneous and aggressive blood cancer, does not respond well to single-drug therapy. A...
PKC-independent PI3K signalling diminishes PKC inhibitor sensitivity in uveal melanoma
PKC-independent PI3K signalling diminishes PKC inhibitor sensitivity in uveal melanoma
Protein kinase C (PKC) is activated downstream of gain-of-function GNAQ or GNA11 (GNAQ/GNA11) mutations in over 90% of uve...
DDX3X interacts with SIRT7 to promote PD-L1 expression to facilitate PDAC progression
DDX3X interacts with SIRT7 to promote PD-L1 expression to facilitate PDAC progression
Pancreatic ductal adenocarcinoma (PDAC) is recognized as the most aggressive and fatal malignancy. A previous study report...
Preneoplastic cells switch to Warburg metabolism from their inception exposing multiple vulnerabilities for targeted elimination
Preneoplastic cells switch to Warburg metabolism from their inception exposing multiple vulnerabilities for targeted elimination
Otto Warburg described tumour cells as displaying enhanced aerobic glycolysis whilst maintaining defective oxidative phosp...
LUBAC promotes angiogenesis and lung tumorigenesis by ubiquitinating and antagonizing autophagic degradation of HIF1α
LUBAC promotes angiogenesis and lung tumorigenesis by ubiquitinating and antagonizing autophagic degradation of HIF1α
Hypoxia-inducible factor 1 (HIF1) is critically important for driving angiogenesis and tumorigenesis. Linear ubiquitin cha...
Correction: TRIM11 facilitates chemoresistance in nasopharyngeal carcinoma by activating the β-catenin/ABCC9 axis via p62-selective autophagic degradation of Daple
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
A cyclin D1 intrinsically disordered domain accesses modified histone motifs to govern gene transcription
A cyclin D1 intrinsically disordered domain accesses modified histone motifs to govern gene transcription
The essential G1-cyclin, CCND1, is frequently overexpressed in cancer, contributing to tumorigenesis by driving cell-cycle...
SMYD3 promotes endometrial cancer through epigenetic regulation of LIG4/XRCC4/XLF complex in non-homologous end joining repair
SMYD3 promotes endometrial cancer through epigenetic regulation of LIG4/XRCC4/XLF complex in non-homologous end joining repair
Endometrial cancer (EC) stands as one of the most prevalent malignancies affecting the female genital tract, witnessing a ...
Transcriptomic analysis identifies B-lymphocyte kinase as a therapeutic target for desmoplastic small round cell tumor cancer stem cell-like cells
Transcriptomic analysis identifies B-lymphocyte kinase as a therapeutic target for desmoplastic small round cell tumor cancer stem cell-like cells
Desmoplastic small round cell tumor (DSRCT) is an aggressive pediatric cancer caused by the EWSR1-WT1 fusion oncoprotein. ...
Cell competition and cancer from Drosophila to mammals
Cell competition and cancer from Drosophila to mammals
Throughout an individual’s life, somatic cells acquire cancer-associated mutations. A fraction of these mutations tr...
Programmed cell death 11 modulates but not entirely relies on p53-HDM2 loop to facilitate G2/M transition in colorectal cancer cells
Programmed cell death 11 modulates but not entirely relies on p53-HDM2 loop to facilitate G2/M transition in colorectal cancer cells
We previously described a nucleolar protein RSL1D1 but distributed throughout the nucleus in HCT116 colorectal cancer (CRC...
Identifying a locus in super-enhancer and its resident NFE2L1/MAFG as transcriptional factors that drive PD-L1 expression and immune evasion
Identifying a locus in super-enhancer and its resident NFE2L1/MAFG as transcriptional factors that drive PD-L1 expression and immune evasion
Although the transcriptional regulation of the programmed death ligand 1 (PD-L1) promoter has been extensively studied, th...
NF-κB signaling activation and roles in thyroid cancers: implication of MAP3K14/NIK
NF-κB signaling activation and roles in thyroid cancers: implication of MAP3K14/NIK
Among follicular-derived thyroid cancers (TC), those with aggressive behavior and resistance to current treatments display...
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