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Correction: Overexpression of SMC4 activates TGFβ/Smad signaling and promotes aggressive phenotype in glioma cells
Correction: Overexpression of SMC4 activates TGFβ/Smad signaling and promotes aggressive phenotype in glioma cells
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Ablation of sphingosine kinase 2 suppresses fatty liver-associated hepatocellular carcinoma via downregulation of ceramide transfer protein
Ablation of sphingosine kinase 2 suppresses fatty liver-associated hepatocellular carcinoma via downregulation of ceramide transfer protein
Hepatocellular carcinoma (HCC) accounts for 90% of primary liver cancer, the third leading cause of cancer-associated deat...
DUSP5P1 promotes gastric cancer metastasis and platinum drug resistance
DUSP5P1 promotes gastric cancer metastasis and platinum drug resistance
We elucidated the functional significance and molecular mechanisms of DUSP5P1 lncRNA (dual specificity phosphatase 5 pseud...
The SUMO protease SENP1 promotes aggressive behaviors of high HIF2α expressing renal cell carcinoma cells
The SUMO protease SENP1 promotes aggressive behaviors of high HIF2α expressing renal cell carcinoma cells
While an important role for the SUMO protease SENP1 is recognized in multiple solid cancers, its role in renal cell carcin...
Metabolic guidance and stress in tumors modulate antigen-presenting cells
Metabolic guidance and stress in tumors modulate antigen-presenting cells
Successful antitumor immunity largely relies on efficient T cell priming by antigen-presenting cells (APCs); however, the ...
Non-genetic stratification reveals epigenetic heterogeneity and identifies vulnerabilities of glycolysis addiction in lung adenocarcinoma subtype
Non-genetic stratification reveals epigenetic heterogeneity and identifies vulnerabilities of glycolysis addiction in lung adenocarcinoma subtype
Lung adenocarcinoma (LUAD) exhibits high heterogeneity and is well known for its high genetic variation. Recently, the und...
A MYC-ZNF148-ID1/3 regulatory axis modulating cancer stem cell traits in aggressive breast cancer
A MYC-ZNF148-ID1/3 regulatory axis modulating cancer stem cell traits in aggressive breast cancer
The MYC proto-oncogene (MYC) is one of the most frequently overexpressed genes in breast cancer that drives cancer stem ce...
Mitochondrial dysfunction and impaired growth of glioblastoma cell lines caused by antimicrobial agents inducing ferroptosis under glucose starvation
Mitochondrial dysfunction and impaired growth of glioblastoma cell lines caused by antimicrobial agents inducing ferroptosis under glucose starvation
Glioblastoma is a difficult-to-cure disease owing to its malignancy. Under normal circumstances, cancer is dependent on th...
Heparanase modulates the prognosis and development of BRAF V600E-mutant colorectal cancer by regulating AKT/p27Kip1/Cyclin E2 pathway
Heparanase modulates the prognosis and development of BRAF V600E-mutant colorectal cancer by regulating AKT/p27Kip1/Cyclin E2 pathway
BRAF V600E-mutant colorectal cancer (CRC) is a rare subtype of colorectal cancer with poor prognosis. Compelling evidence ...
Blockage of Orai1-Nucleolin interaction meditated calcium influx attenuates breast cancer cells growth
Blockage of Orai1-Nucleolin interaction meditated calcium influx attenuates breast cancer cells growth
As an important second messenger, calcium (Ca2+) regulates a wide variety of physiological processes. Disturbance of intra...
Exosomes and cancer - Diagnostic and prognostic biomarkers and therapeutic vehicle
Exosomes and cancer - Diagnostic and prognostic biomarkers and therapeutic vehicle
Exosomes belong to a subpopulation of extracellular vesicles secreted by the dynamic multistep endocytosis process and car...
Hypoxia promotes an inflammatory phenotype of fibroblasts in pancreatic cancer
Hypoxia promotes an inflammatory phenotype of fibroblasts in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extensive fibroinflammatory stroma and often experiences co...
PFKFB4 interacts with FBXO28 to promote HIF-1α signaling in glioblastoma
PFKFB4 interacts with FBXO28 to promote HIF-1α signaling in glioblastoma
Glioblastoma is a highly aggressive brain tumor for which there is no cure. The metabolic enzyme 6-Phosphofructo-2-Kinase/...
Comparison of the mutational profiles of neuroendocrine breast tumours, invasive ductal carcinomas and pancreatic neuroendocrine carcinomas
Comparison of the mutational profiles of neuroendocrine breast tumours, invasive ductal carcinomas and pancreatic neuroendocrine carcinomas
The pathophysiology and the optimal treatment of breast neuroendocrine tumours (NETs) are unknown. We compared the mutatio...
Engineered model of t(7;12)(q36;p13) AML recapitulates patient-specific features and gene expression profiles
Engineered model of t(7;12)(q36;p13) AML recapitulates patient-specific features and gene expression profiles
Acute myeloid leukaemia carrying the translocation t(7;12)(q36;p13) is an adverse-risk leukaemia uniquely observed in infa...
UHRF1 overexpression promotes osteosarcoma metastasis through altered exosome production and AMPK/SEMA3E suppression
UHRF1 overexpression promotes osteosarcoma metastasis through altered exosome production and AMPK/SEMA3E suppression
Loss-of-function mutations at the retinoblastoma (RB1) gene are associated with increased mortality, metastasis, and poor ...
A novel uterine leiomyoma subtype exhibits NRF2 activation and mutations in genes associated with neddylation of the Cullin 3-RING E3 ligase
A novel uterine leiomyoma subtype exhibits NRF2 activation and mutations in genes associated with neddylation of the Cullin 3-RING E3 ligase
Uterine leiomyomas, or fibroids, are the most common tumors in women of reproductive age. Uterine leiomyomas can be classi...
Non-enzymatic heparanase enhances gastric tumor proliferation via TFEB-dependent autophagy
Non-enzymatic heparanase enhances gastric tumor proliferation via TFEB-dependent autophagy
Heparanase (HPA) is the predominant enzyme that cleaves heparan sulfate and plays a critical role in a variety of pathophy...
Lipids in cancer: a global view of the contribution of lipid pathways to metastatic formation and treatment resistance
Lipids in cancer: a global view of the contribution of lipid pathways to metastatic formation and treatment resistance
Lipids are essential constituents for malignant tumors, as they are absolutely required for tumor growth and dissemination...
Diltiazem inhibits breast cancer metastasis via mediating growth differentiation factor 15 and epithelial-mesenchymal transition
Diltiazem inhibits breast cancer metastasis via mediating growth differentiation factor 15 and epithelial-mesenchymal transition
Migration and metastasis commonly happen to triple-negative breast cancer (TNBC) patients with advanced diseases. In many ...
Tumor-derived miR-130b-3p induces cancer-associated fibroblast activation by targeting SPIN90 in luminal A breast cancer
Tumor-derived miR-130b-3p induces cancer-associated fibroblast activation by targeting SPIN90 in luminal A breast cancer
Cancer-associated fibroblasts (CAFs) in the tumor microenvironment (TME) interact closely with cancer cells to promote tum...
Methylation of HBP1 by PRMT1 promotes tumor progression by regulating actin cytoskeleton remodeling
Methylation of HBP1 by PRMT1 promotes tumor progression by regulating actin cytoskeleton remodeling
HBP1 is a sequence-specific transcription factor which generally considered as a crucial growth inhibitor. Posttranslation...
ZNF655 accelerates progression of pancreatic cancer by promoting the binding of E2F1 and CDK1
ZNF655 accelerates progression of pancreatic cancer by promoting the binding of E2F1 and CDK1
Pancreatic cancer has an extremely terrible prognosis and is a common cause of cancer death. In this study, the clinic val...
The impact of neoadjuvant chemotherapy on the tumor microenvironment in advanced high-grade serous carcinoma
The impact of neoadjuvant chemotherapy on the tumor microenvironment in advanced high-grade serous carcinoma
High-grade serous ovarian, fallopian tube or peritoneal carcinoma is an aggressive subtype of ovarian cancer that frequent...
Paladin, overexpressed in colon cancer, is required for actin polymerisation and liver metastasis dissemination
Paladin, overexpressed in colon cancer, is required for actin polymerisation and liver metastasis dissemination
Colorectal cancer remains a public health issue and most colon cancer patients succumb to the development of metastases. U...
Heterozygotic Brca1 mutation initiates mouse genome instability at embryonic stage
Heterozygotic Brca1 mutation initiates mouse genome instability at embryonic stage
BRCA1 mutation is the genetic predisposition in causing genome instability towards cancer. BRCA1 mutation is predominantly...
NNMT promotes the progression of intrahepatic cholangiocarcinoma by regulating aerobic glycolysis via the EGFR-STAT3 axis
NNMT promotes the progression of intrahepatic cholangiocarcinoma by regulating aerobic glycolysis via the EGFR-STAT3 axis
Nicotinamide N-methyltransferase (NNMT), a member of the N-methyltransferase family, plays an important role in tumorigene...
The E3 ubiquitin ligase MG53 inhibits hepatocellular carcinoma by targeting RAC1 signaling
The E3 ubiquitin ligase MG53 inhibits hepatocellular carcinoma by targeting RAC1 signaling
Ras-related C3 botulinum toxin substrate 1 (RAC1) overexpressiosn and hyperactivation are correlated with aggressive growt...