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Correction: FAM83B inhibits ovarian cancer cisplatin resistance through inhibiting Wnt pathway
Correction: FAM83B inhibits ovarian cancer cisplatin resistance through inhibiting Wnt pathway
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Retraction Note: A natural food sweetener with anti-pancreatic cancer properties
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Overexpression of tripartite motif-containing 47 (TRIM47) confers sensitivity to PARP inhibition via ubiquitylation of BRCA1 in triple negative breast cancer cells
Overexpression of tripartite motif-containing 47 (TRIM47) confers sensitivity to PARP inhibition via ubiquitylation of BRCA1 in triple negative breast cancer cells
Triple-negative breast cancers (TNBC) frequently harbor defects in DNA double-strand break repair through homologous recom...
Correction: Human colon cancer cells highly express myoferlin to maintain a fit mitochondrial network and escape p53-driven apoptosis
Correction: Human colon cancer cells highly express myoferlin to maintain a fit mitochondrial network and escape p53-driven apoptosis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
USP35 promotes cell proliferation and chemotherapeutic resistance through stabilizing FUCA1 in colorectal cancer
USP35 promotes cell proliferation and chemotherapeutic resistance through stabilizing FUCA1 in colorectal cancer
Ubiquitin-specific-processing proteases 35 (USP35) is an under-characterized deubiquitinase and its role in colorectal can...
PELI1 and EGFR cooperate to promote breast cancer metastasis
PELI1 and EGFR cooperate to promote breast cancer metastasis
Pellino-1 (PELI1) is an E3 ubiquitin ligase acting as a key regulator for the inflammation and autoimmunity via the ubiqui...
Targeted metabolomics detects a putatively diagnostic signature in plasma and dried blood spots from head and neck paraganglioma patients
Targeted metabolomics detects a putatively diagnostic signature in plasma and dried blood spots from head and neck paraganglioma patients
Head and neck paragangliomas (HNPGLs), rare chemoresistant tumors curable only with surgery, are strongly influenced by ge...
Generating in vitro models of NTRK-fusion mesenchymal neoplasia as tools for investigating kinase oncogenic activation and response to targeted therapy
Generating in vitro models of NTRK-fusion mesenchymal neoplasia as tools for investigating kinase oncogenic activation and response to targeted therapy
The discovery of neurotrophic tyrosine receptor kinase (NTRK) gene fusions as pan-tumor oncogenic drivers has led to new p...
The mechanical phenotypic plasticity of melanoma cell: an emerging driver of therapy cross-resistance
The mechanical phenotypic plasticity of melanoma cell: an emerging driver of therapy cross-resistance
Advanced cutaneous melanoma is the deadliest form of skin cancer and one of the most aggressive human cancers. Targeted th...
Negligible role of TRAIL death receptors in cell death upon endoplasmic reticulum stress in B-cell malignancies
Negligible role of TRAIL death receptors in cell death upon endoplasmic reticulum stress in B-cell malignancies
Impairments in protein folding in the endoplasmic reticulum (ER) lead to a condition called ER stress, which can trigger a...
Spindle function and Wnt pathway inhibition by PBX1 to suppress tumor progression via downregulating DCDC2 in colorectal cancer
Spindle function and Wnt pathway inhibition by PBX1 to suppress tumor progression via downregulating DCDC2 in colorectal cancer
PBX1 is a transcription factor that regulates a variety of genes, involved in intracellular lipid metabolism, cell prolife...
Androgen receptor variant 7 exacerbates hepatocarcinogenesis in a c-MYC-driven mouse HCC model
Androgen receptor variant 7 exacerbates hepatocarcinogenesis in a c-MYC-driven mouse HCC model
Androgen receptor variant 7 (AR-V7), an AR isoform with a truncated ligand-binding domain, functions as a transcription fa...
COX-2/PGE2 upregulation contributes to the chromosome 17p-deleted lymphoma
COX-2/PGE2 upregulation contributes to the chromosome 17p-deleted lymphoma
Deletions of chromosome 17p, where TP53 gene locates, are the most frequent chromosome alterations in human cancers and as...
HLTF promotes hepatocellular carcinoma progression by enhancing SRSF1 stability and activating ERK/MAPK pathway
HLTF promotes hepatocellular carcinoma progression by enhancing SRSF1 stability and activating ERK/MAPK pathway
Helicase-like transcription factor (HLTF) has been found to be involved in the progression of several tumors, but the role...
AKT1 regulates UHRF1 protein stability and promotes the resistance to abiraterone in prostate cancer
AKT1 regulates UHRF1 protein stability and promotes the resistance to abiraterone in prostate cancer
Oncogenic activation of PI3K/AKT signaling pathway, together with epigenetic aberrations are the characters of castration-...
LPA receptor 1 (LPAR1) is a novel interaction partner of Filamin A that promotes Filamin A phosphorylation, MRTF-A transcriptional activity and oncogene-induced senescence
LPA receptor 1 (LPAR1) is a novel interaction partner of Filamin A that promotes Filamin A phosphorylation, MRTF-A transcriptional activity and oncogene-induced senescence
Myocardin-related transcription factors A and B (MRTFs) are coactivators of Serum Response Factor (SRF), which controls fu...
Correction: Overexpression of SMC4 activates TGFβ/Smad signaling and promotes aggressive phenotype in glioma cells
Correction: Overexpression of SMC4 activates TGFβ/Smad signaling and promotes aggressive phenotype in glioma cells
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Ablation of sphingosine kinase 2 suppresses fatty liver-associated hepatocellular carcinoma via downregulation of ceramide transfer protein
Ablation of sphingosine kinase 2 suppresses fatty liver-associated hepatocellular carcinoma via downregulation of ceramide transfer protein
Hepatocellular carcinoma (HCC) accounts for 90% of primary liver cancer, the third leading cause of cancer-associated deat...
DUSP5P1 promotes gastric cancer metastasis and platinum drug resistance
DUSP5P1 promotes gastric cancer metastasis and platinum drug resistance
We elucidated the functional significance and molecular mechanisms of DUSP5P1 lncRNA (dual specificity phosphatase 5 pseud...
The SUMO protease SENP1 promotes aggressive behaviors of high HIF2α expressing renal cell carcinoma cells
The SUMO protease SENP1 promotes aggressive behaviors of high HIF2α expressing renal cell carcinoma cells
While an important role for the SUMO protease SENP1 is recognized in multiple solid cancers, its role in renal cell carcin...
Correction: Mitochondrial dysfunction and impaired growth of glioblastoma cell lines caused by antimicrobial agents inducing ferroptosis under glucose starvation
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Metabolic guidance and stress in tumors modulate antigen-presenting cells
Metabolic guidance and stress in tumors modulate antigen-presenting cells
Successful antitumor immunity largely relies on efficient T cell priming by antigen-presenting cells (APCs); however, the ...
Retraction Note: Cadherin 6 is activated by Epstein–Barr virus LMP1 to mediate EMT and metastasis as an interplay node of multiple pathways in nasopharyngeal carcinoma
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Non-genetic stratification reveals epigenetic heterogeneity and identifies vulnerabilities of glycolysis addiction in lung adenocarcinoma subtype
Non-genetic stratification reveals epigenetic heterogeneity and identifies vulnerabilities of glycolysis addiction in lung adenocarcinoma subtype
Lung adenocarcinoma (LUAD) exhibits high heterogeneity and is well known for its high genetic variation. Recently, the und...
A MYC-ZNF148-ID1/3 regulatory axis modulating cancer stem cell traits in aggressive breast cancer
A MYC-ZNF148-ID1/3 regulatory axis modulating cancer stem cell traits in aggressive breast cancer
The MYC proto-oncogene (MYC) is one of the most frequently overexpressed genes in breast cancer that drives cancer stem ce...
Mitochondrial dysfunction and impaired growth of glioblastoma cell lines caused by antimicrobial agents inducing ferroptosis under glucose starvation
Mitochondrial dysfunction and impaired growth of glioblastoma cell lines caused by antimicrobial agents inducing ferroptosis under glucose starvation
Glioblastoma is a difficult-to-cure disease owing to its malignancy. Under normal circumstances, cancer is dependent on th...
Heparanase modulates the prognosis and development of BRAF V600E-mutant colorectal cancer by regulating AKT/p27Kip1/Cyclin E2 pathway
Heparanase modulates the prognosis and development of BRAF V600E-mutant colorectal cancer by regulating AKT/p27Kip1/Cyclin E2 pathway
BRAF V600E-mutant colorectal cancer (CRC) is a rare subtype of colorectal cancer with poor prognosis. Compelling evidence ...
Blockage of Orai1-Nucleolin interaction meditated calcium influx attenuates breast cancer cells growth
Blockage of Orai1-Nucleolin interaction meditated calcium influx attenuates breast cancer cells growth
As an important second messenger, calcium (Ca2+) regulates a wide variety of physiological processes. Disturbance of intra...
Exosomes and cancer - Diagnostic and prognostic biomarkers and therapeutic vehicle
Exosomes and cancer - Diagnostic and prognostic biomarkers and therapeutic vehicle
Exosomes belong to a subpopulation of extracellular vesicles secreted by the dynamic multistep endocytosis process and car...
Hypoxia promotes an inflammatory phenotype of fibroblasts in pancreatic cancer
Hypoxia promotes an inflammatory phenotype of fibroblasts in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extensive fibroinflammatory stroma and often experiences co...
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