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AIFM2 promotes hepatocellular carcinoma metastasis by enhancing mitochondrial biogenesis through activation of SIRT1/PGC-1α signaling
AIFM2 promotes hepatocellular carcinoma metastasis by enhancing mitochondrial biogenesis through activation of SIRT1/PGC-1α signaling
AIFM2 is a crucial NADH oxidase involved in the regulation of cytosolic NAD+. However, the role of AIFM2 in the progressio...
Discovery of neddylation E2s inhibitors with therapeutic activity
Discovery of neddylation E2s inhibitors with therapeutic activity
Neddylation is the writing of monomers or polymers of neural precursor cells expressed developmentally down-regulated 8 (N...
Biological differences underlying sex and gender disparities in bladder cancer: current synopsis and future directions
Biological differences underlying sex and gender disparities in bladder cancer: current synopsis and future directions
Sex and gender disparities in bladder cancer have long been a subject of interest to the cancer research community, wherei...
Correction: Non-enzymatic heparanase enhances gastric tumor proliferation via TFEB-dependent autophagy
Correction: Non-enzymatic heparanase enhances gastric tumor proliferation via TFEB-dependent autophagy
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Glucocorticoid receptor-induced non-muscle caldesmon regulates metastasis in castration-resistant prostate cancer
Glucocorticoid receptor-induced non-muscle caldesmon regulates metastasis in castration-resistant prostate cancer
Lethal prostate cancer (PCa) is characterized by the presence of metastases and development of resistance to therapies. Me...
SLC26A3/NHERF2-IκB/NFκB/p65 feedback loop suppresses tumorigenesis and metastasis in colorectal cancer
SLC26A3/NHERF2-IκB/NFκB/p65 feedback loop suppresses tumorigenesis and metastasis in colorectal cancer
Colorectal cancer (CRC) is a formidable disease due to the intricate mechanisms that drive its proliferation and metastasi...
Loss of Pkd1 limits susceptibility to colitis and colorectal cancer
Loss of Pkd1 limits susceptibility to colitis and colorectal cancer
Colorectal cancer (CRC) is one of the most common cancers, with an annual incidence of ~135,000 in the US, associated with...
Retraction Note: Acetyl-CoA synthetase 3 promotes bladder cancer cell growth under metabolic stress
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Correction: Targeting IL-3Rα on tumor-derived endothelial cells blunts metastatic spread of triple-negative breast cancer via extracellular vesicle reprogramming
Correction: Targeting IL-3Rα on tumor-derived endothelial cells blunts metastatic spread of triple-negative breast cancer via extracellular vesicle reprogramming
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Deep learning identifies a T-cell exhaustion-dependent transcriptional signature for predicting clinical outcomes and response to immune checkpoint blockade
Deep learning identifies a T-cell exhaustion-dependent transcriptional signature for predicting clinical outcomes and response to immune checkpoint blockade
Immune checkpoint blockade (ICB) therapies have brought unprecedented advances in cancer treatment, but responses are limi...
The tumor suppressor CREBBP and the oncogene MYCN cooperate to induce malignant brain tumors in mice
The tumor suppressor CREBBP and the oncogene MYCN cooperate to induce malignant brain tumors in mice
The tumor suppressor and chromatin modifier cAMP response element-binding protein binding protein (CREBBP) and v-myc avian...
MLK4 promotes glucose metabolism in lung adenocarcinoma through CREB-mediated activation of phosphoenolpyruvate carboxykinase and is regulated by KLF5
MLK4 promotes glucose metabolism in lung adenocarcinoma through CREB-mediated activation of phosphoenolpyruvate carboxykinase and is regulated by KLF5
MLK4, a member of the mitogen-activated protein kinase kinase kinase (MAP3K) family, has been implicated in cancer progres...
Chemotherapy-induced executioner caspase activation increases breast cancer malignancy through epigenetic de-repression of CDH12
Chemotherapy-induced executioner caspase activation increases breast cancer malignancy through epigenetic de-repression of CDH12
Cancer relapse and metastasis are major obstacles for effective treatment. One important mechanism to eliminate cancer cel...
Antibody-based binding domain fused to TCRγ chain facilitates T cell cytotoxicity for potent anti-tumor response
Antibody-based binding domain fused to TCRγ chain facilitates T cell cytotoxicity for potent anti-tumor response
Chimeric antigen receptor T-cell (CAR-T) therapy has demonstrated potent clinical efficacy in the treatment of hematopoiet...
WDR5 facilitates recruitment of N-MYC to conserved WDR5 gene targets in neuroblastoma cell lines
WDR5 facilitates recruitment of N-MYC to conserved WDR5 gene targets in neuroblastoma cell lines
Collectively, the MYC family of oncoprotein transcription factors is overexpressed in more than half of all malignancies. ...
Integrated analysis of single-cell and bulk RNA sequencing data reveals an immunostimulatory microenvironment in tumor thrombus of osteosarcoma
Integrated analysis of single-cell and bulk RNA sequencing data reveals an immunostimulatory microenvironment in tumor thrombus of osteosarcoma
Tumor thrombus of bone sarcomas represents a unique reservoir for various types of cancer and immune cells, however, the i...
Phosphorylation of IWS1 by AKT maintains liposarcoma tumor heterogeneity through preservation of cancer stem cell phenotypes and mesenchymal-epithelial plasticity
Phosphorylation of IWS1 by AKT maintains liposarcoma tumor heterogeneity through preservation of cancer stem cell phenotypes and mesenchymal-epithelial plasticity
Chemotherapy remains the mainstay of treatment for patients with advanced liposarcoma (LPS), but response rates are only 2...
CDK4/6 inhibitors and the pRB-E2F1 axis suppress PVR and PD-L1 expression in triple-negative breast cancer
CDK4/6 inhibitors and the pRB-E2F1 axis suppress PVR and PD-L1 expression in triple-negative breast cancer
Immune-checkpoint (IC) modulators like the poliovirus receptor (PVR) and programmed death ligand 1 (PD-L1) attenuate innat...
Circlehunter: a tool to identify extrachromosomal circular DNA from ATAC-Seq data
Circlehunter: a tool to identify extrachromosomal circular DNA from ATAC-Seq data
In cancer, extrachromosomal circular DNA (ecDNA), or megabase-pair amplified circular DNA, plays an essential role in inte...
Correction: USP53 plays an antitumor role in hepatocellular carcinoma through deubiquitination of cytochrome c
Correction: USP53 plays an antitumor role in hepatocellular carcinoma through deubiquitination of cytochrome c
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Dual role of ANGPTL8 in promoting tumor cell proliferation and immune escape during hepatocarcinogenesis
Dual role of ANGPTL8 in promoting tumor cell proliferation and immune escape during hepatocarcinogenesis
The interplay between hepatocellular carcinoma (HCC) cells and the tumor microenvironment is essential for hepatocarcinoge...
miR-137–LAPTM4B regulates cytoskeleton organization and cancer metastasis via the RhoA-LIMK-Cofilin pathway in osteosarcoma
miR-137–LAPTM4B regulates cytoskeleton organization and cancer metastasis via the RhoA-LIMK-Cofilin pathway in osteosarcoma
Osteosarcoma (OS) is a rare malignant bone tumor but is one leading cause of cancer mortality in childhood and adolescence...
Vortioxetine hydrobromide inhibits the growth of gastric cancer cells in vivo and in vitro by targeting JAK2 and SRC
Vortioxetine hydrobromide inhibits the growth of gastric cancer cells in vivo and in vitro by targeting JAK2 and SRC
Gastric cancer is the fourth leading cause of cancer deaths worldwide. Most patients are diagnosed in the advanced stage. ...
Retinoic acid receptor β modulates mechanosensing and invasion in pancreatic cancer cells via myosin light chain 2
Retinoic acid receptor β modulates mechanosensing and invasion in pancreatic cancer cells via myosin light chain 2
Pancreatic ductal adenocarcinoma (PDAC) is the most common and lethal form of pancreatic cancer, characterised by stromal ...
Anti-PD-1 therapy achieves favorable outcomes in HBV-positive non-liver cancer
Anti-PD-1 therapy achieves favorable outcomes in HBV-positive non-liver cancer
Anti-PD-1 therapy has shown promising outcomes in the treatment of different types of cancer. It is of fundamental interes...
Exploring potential molecular resistance and clonal evolution in advanced HER2-positive gastric cancer under trastuzumab therapy
Exploring potential molecular resistance and clonal evolution in advanced HER2-positive gastric cancer under trastuzumab therapy
HER2-positive gastric cancer (GC) makes up 15–20% of all GC incidences, and targeted therapy with trastuzumab is the...
PKD phosphorylation and COP9/Signalosome modulate intracellular Spry2 protein stability
PKD phosphorylation and COP9/Signalosome modulate intracellular Spry2 protein stability
Spry2 is a molecular modulator of tyrosine kinase receptor signaling pathways that has cancer-type-specific effects. Mamma...
ACT001 inhibited CD133 transcription by targeting and inducing Olig2 ubiquitination degradation
ACT001 inhibited CD133 transcription by targeting and inducing Olig2 ubiquitination degradation
Lung cancer is the most lethal malignancies with high aggressive and poor prognosis. Until now, the five-year survival rat...
Transgelin promotes lung cancer progression via activation of cancer-associated fibroblasts with enhanced IL-6 release
Transgelin promotes lung cancer progression via activation of cancer-associated fibroblasts with enhanced IL-6 release
Cancer-associated fibroblasts (CAFs), the principal constituent of the heterogenous tumor microenvironment, have been show...
The p52-ZER6/G6PD axis alters aerobic glycolysis and promotes tumor progression by activating the pentose phosphate pathway
The p52-ZER6/G6PD axis alters aerobic glycolysis and promotes tumor progression by activating the pentose phosphate pathway
Abnormal glucose metabolism is a highlight of tumor metabolic reprogramming and is closely related to the development of m...
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