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Sertraline/chloroquine combination therapy to target hypoxic and immunosuppressive serine/glycine synthesis-dependent glioblastomas
Sertraline/chloroquine combination therapy to target hypoxic and immunosuppressive serine/glycine synthesis-dependent glioblastomas
The serine/glycine (ser/gly) synthesis pathway branches from glycolysis and is hyperactivated in approximately 30% of canc...
Condensate remodeling reorganizes innate SS18 in synovial sarcomagenesis
Condensate remodeling reorganizes innate SS18 in synovial sarcomagenesis
SS18-SSX onco-fusion protein formed through aberrant chromosomal translocation t (X, 18; p11, q11), is the hallmark and pl...
Ubiquitin-specific protease 10 determines colorectal cancer outcome by modulating epidermal growth factor signaling via inositol polyphosphate-4-phosphatase type IIB
Ubiquitin-specific protease 10 determines colorectal cancer outcome by modulating epidermal growth factor signaling via inositol polyphosphate-4-phosphatase type IIB
Although there have been advances in understanding colorectal cancer (CRC) pathogenesis, significant gaps still exist, hig...
The branched N-glycan of PD-L1 predicts immunotherapy responses in patients with recurrent/metastatic HNSCC
The branched N-glycan of PD-L1 predicts immunotherapy responses in patients with recurrent/metastatic HNSCC
Immunotherapy has revolutionized cancer treatment, but the lack of a reliable predictive biomarker for treatment response ...
NRF2 signaling plays an essential role in cancer progression through the NRF2-GPX2-NOTCH3 axis in head and neck squamous cell carcinoma
NRF2 signaling plays an essential role in cancer progression through the NRF2-GPX2-NOTCH3 axis in head and neck squamous cell carcinoma
The activation of nuclear factor erythroid 2–related factor 2 (NRF2) has been observed in various cancers. Yet its e...
DKK1 as a chemoresistant protein modulates oxaliplatin responses in colorectal cancer
DKK1 as a chemoresistant protein modulates oxaliplatin responses in colorectal cancer
Oxaliplatin is effective against colorectal cancer (CRC), but resistance hampers treatment. We found upregulated Dickkopf-...
TFCP2L1 drives stemness and enhances their resistance to Sorafenib treatment by modulating the NANOG/STAT3 pathway in hepatocellular carcinoma
TFCP2L1 drives stemness and enhances their resistance to Sorafenib treatment by modulating the NANOG/STAT3 pathway in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a prevalent and aggressive malignancy associated with high risks of recurrence and metas...
Correction: Dihydroartemisinin inhibits prostate cancer via JARID2/miR-7/miR-34a-dependent downregulation of Axl
Correction: Dihydroartemisinin inhibits prostate cancer via JARID2/miR-7/miR-34a-dependent downregulation of Axl
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4....
Tumor suppressor BAP1 suppresses disulfidptosis through the regulation of SLC7A11 and NADPH levels
Tumor suppressor BAP1 suppresses disulfidptosis through the regulation of SLC7A11 and NADPH levels
BAP1, BRCA1-Associated Protein 1, serves as a novel tumor suppressor through the deubiquitination of monoubiquitination of...
Peptidylarginine deiminase 3 modulates response to neratinib in HER2 positive breast cancer
Peptidylarginine deiminase 3 modulates response to neratinib in HER2 positive breast cancer
Neratinib is a tyrosine kinase inhibitor that is used for the therapy of patients with HER2+ breast tumors. However, despi...
Cell competition in primary and metastatic colorectal cancer
Cell competition in primary and metastatic colorectal cancer
Adult tissues set the scene for a continuous battle between cells, where a comparison of cellular fitness results in the e...
Combined Inhibition of PI3K and STAT3 signaling effectively inhibits bladder cancer growth
Combined Inhibition of PI3K and STAT3 signaling effectively inhibits bladder cancer growth
Bladder cancer is characterized by aberrant activation of the phosphatidylinositol-3-OH kinase (PI3K) signaling, underscor...
USP32 facilitates non-small cell lung cancer progression via deubiquitinating BAG3 and activating RAF-MEK-ERK signaling pathway
USP32 facilitates non-small cell lung cancer progression via deubiquitinating BAG3 and activating RAF-MEK-ERK signaling pathway
The regulatory significance of ubiquitin-specific peptidase 32 (USP32) in tumor is significant, nevertheless, the biologic...
Involvement of Kindlin-1 in cutaneous squamous cell carcinoma
Involvement of Kindlin-1 in cutaneous squamous cell carcinoma
Kindler syndrome (KS) is a rare genodermatosis resulting from loss-of-function mutations in FERMT1, the gene that encodes ...
Gemcitabine as chemotherapy of head and neck cancer in Fanconi anemia patients
Gemcitabine as chemotherapy of head and neck cancer in Fanconi anemia patients
Fanconi anemia (FA) is a rare hereditary disease resulting from an inactivating mutation in the FA/BRCA pathway, critical ...
YAP/TAZ interacts with RBM39 to confer resistance against indisulam
YAP/TAZ interacts with RBM39 to confer resistance against indisulam
The Hippo pathway and its downstream effectors, Yes-associated protein/transcriptional coactivator with PDZ-binding motif ...
USP21-mediated G3BP1 stabilization accelerates proliferation and metastasis of esophageal squamous cell carcinoma via activating Wnt/β-Catenin signaling
USP21-mediated G3BP1 stabilization accelerates proliferation and metastasis of esophageal squamous cell carcinoma via activating Wnt/β-Catenin signaling
Lacking effective therapeutic targets heavily restricts the improvement of clinical prognosis for patients diagnosed with ...
Activated platelet-derived exosomal LRG1 promotes multiple myeloma cell growth
Activated platelet-derived exosomal LRG1 promotes multiple myeloma cell growth
The hypercoagulable state is a hallmark for patients with multiple myeloma (MM) and is associated with disease progression...
Comprehensive multi-omics analysis of breast cancer reveals distinct long-term prognostic subtypes
Comprehensive multi-omics analysis of breast cancer reveals distinct long-term prognostic subtypes
Breast cancer (BC) is a leading cause of cancer-related death worldwide. The diverse nature and heterogeneous biology of B...
DAB2IP inhibits glucose uptake by modulating HIF-1α ubiquitination under hypoxia in breast cancer
DAB2IP inhibits glucose uptake by modulating HIF-1α ubiquitination under hypoxia in breast cancer
Metabolic reprogramming has become increasingly important in tumor biology research. The glucose metabolic pathway is a ma...
Retraction Note: Platelet-derived growth factor receptor-α and -β promote cancer stem cell phenotypes in sarcomas
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Retraction Note: PI3K/Akt pathway and Nanog maintain cancer stem cells in sarcomas
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Mitotic MTH1 inhibitor TH1579 induces PD-L1 expression and inflammatory response through the cGAS-STING pathway
Mitotic MTH1 inhibitor TH1579 induces PD-L1 expression and inflammatory response through the cGAS-STING pathway
The mitotic MTH1 inhibitor TH1579 is a dual inhibitor that inhibits mitosis and incorporation of oxidative DNA damage and ...
An E3 ligase TRIM1 promotes colorectal cancer progression via K63-linked ubiquitination and activation of HIF1α
An E3 ligase TRIM1 promotes colorectal cancer progression via K63-linked ubiquitination and activation of HIF1α
Accumulating studies have shown that E3 ligases play crucial roles in regulating cellular biological processes and signali...
NAC1 transcriptional activation of LDHA induces hepatitis B virus immune evasion leading to cirrhosis and hepatocellular carcinoma development
NAC1 transcriptional activation of LDHA induces hepatitis B virus immune evasion leading to cirrhosis and hepatocellular carcinoma development
Our study aimed to elucidate the molecular mechanisms underlying NAC1 (nucleus accumbens associated 1) transcriptional reg...
Phenotyping of cancer-associated somatic mutations in the BCL2 transmembrane domain
Phenotyping of cancer-associated somatic mutations in the BCL2 transmembrane domain
The BCL2 family of proteins controls cell death by modulating the permeabilization of the mitochondrial outer membrane thr...
Acidovorax temperans skews neutrophil maturation and polarizes Th17 cells to promote lung adenocarcinoma development
Acidovorax temperans skews neutrophil maturation and polarizes Th17 cells to promote lung adenocarcinoma development
Change within the intratumoral microbiome is a common feature in lung and other cancers and may influence inflammation and...
RIOK3 sustains colorectal cancer cell survival under glucose deprivation via an HSP90α-dependent pathway
RIOK3 sustains colorectal cancer cell survival under glucose deprivation via an HSP90α-dependent pathway
Glucose oxidation via the pentose phosphate pathway serves as the primary cellular mechanism for generating nicotinamide a...
Progesterone receptor potentiates macropinocytosis through CDC42 in pancreatic ductal adenocarcinoma
Progesterone receptor potentiates macropinocytosis through CDC42 in pancreatic ductal adenocarcinoma
Endocrine receptors play an essential role in tumor metabolic reprogramming and represent a promising therapeutic avenue i...
Designing patient-oriented combination therapies for acute myeloid leukemia based on efficacy/toxicity integration and bipartite network modeling
Designing patient-oriented combination therapies for acute myeloid leukemia based on efficacy/toxicity integration and bipartite network modeling
Acute myeloid leukemia (AML), a heterogeneous and aggressive blood cancer, does not respond well to single-drug therapy. A...
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