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Backbone distortions in lactam‐bridged helical peptides
Backbone distortions in lactam‐bridged helical peptides
Side-chain-to-side-chain cyclization is frequently used to stabilize the α-helical conformation of short peptides. I...
Identification of β‐aminopyrrolidine containing peptides as β‐amyloid aggregation inhibitors for Alzheimer's disease
Identification of β‐aminopyrrolidine containing peptides as β‐amyloid aggregation inhibitors for Alzheimer's disease
Alzheimer's disease (AD) is caused by a series of events initiated by the production and aggregation of the amyloid β...
Laminaria japonica cyclic peptides exert anti‐colorectal carcinoma effects through apoptosis induction in vitro and in vivo
Laminaria japonica cyclic peptides exert anti‐colorectal carcinoma effects through apoptosis induction in vitro and in vivo
Laminaria japonica is consumed as a health food and used as a traditional medicine because of its biochemical and pharmaco...
Targeted β‐catenin ubiquitination and degradation by multifunctional stapled peptides
Targeted β‐catenin ubiquitination and degradation by multifunctional stapled peptides
Aberrant activation of the Wnt signaling pathway has been identified in numerous types of cancer. One common feature of on...
Current synthetic chemistry towards cyclic antimicrobial peptides
Current synthetic chemistry towards cyclic antimicrobial peptides
Antimicrobial peptides (AMPs) have great potentials for developing novel antibiotics against multi-drug resistant (MDR) ba...
Substrate plasticity of dehydratase SpaKC from the biosynthesis of thiosparsoamide
Substrate plasticity of dehydratase SpaKC from the biosynthesis of thiosparsoamide
Thioamitides are a group of ribosomally synthesized and post-translationally modified peptides that possess diverse bioact...
Heterochiral tetrapeptide self‐assembly into hydrogel biomaterials for hydrolase mimicry
Heterochiral tetrapeptide self‐assembly into hydrogel biomaterials for hydrolase mimicry
Self-assembling short peptides have attracted great interest as enzyme mimics, especially if the catalytic activity reside...
Reversible crosslinked assembly of a trimeric coiled‐coil peptide into a three‐dimensional matrix for cell encapsulation and release
Reversible crosslinked assembly of a trimeric coiled‐coil peptide into a three‐dimensional matrix for cell encapsulation and release
Mimicking the extracellular matrix (ECM) continues to be a goal in the field of regenerative medicine. Herein, we report a...
Interactions of two enantiomers of a designer antimicrobial peptide with structural components of the bacterial cell envelope
Interactions of two enantiomers of a designer antimicrobial peptide with structural components of the bacterial cell envelope
Antimicrobial peptides (AMPs) have great potential in treating multi-drug resistant bacterial infections. The antimicrobia...
Peptide‐based hydrogels as delivery systems for doxorubicin
Peptide‐based hydrogels as delivery systems for doxorubicin
Hydrogels (HGs) and nanogels (NGs) have been recently identified as innovative supramolecular materials for many applicati...
Different directions for retro‐inverso peptides
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Antifungal activity and mode of action of synthetic peptides derived from the tick OsDef2 defensin
Antifungal activity and mode of action of synthetic peptides derived from the tick OsDef2 defensin
Candida albicans is the principal opportunistic fungal pathogen in nosocomial settings and resistance to antifungal drugs ...
Novel disintegrin‐like peptides derived from an amphibian skin cDNA sequence of Hypsiboas punctatus
Novel disintegrin‐like peptides derived from an amphibian skin cDNA sequence of Hypsiboas punctatus
Disintegrins comprise a family of small proteins that bind to and alter the physiological function of integrins, especiall...
Chemical methods for studying the crosstalk between histone H2B ubiquitylation and H3 methylation
Chemical methods for studying the crosstalk between histone H2B ubiquitylation and H3 methylation
The reversible and dynamic post-translational modifications (PTMs) of histones in eukaryotic chromatin are intimately conn...
Virtual screening and rational design of antioxidant peptides based on tryptophyllin L structures isolated from the Litoria rubella frog
Virtual screening and rational design of antioxidant peptides based on tryptophyllin L structures isolated from the Litoria rubella frog
Discovery of natural antioxidants has been carried out for decades relying mainly on experimental approaches that are comm...
Editorial: “Peptides in biomaterials science: New trends and applications”
Editorial: “Peptides in biomaterials science: New trends and applications”
Early View e3379 EDITORIAL Carlos Mas-Moruno, Corresponding Author Bio...
Peptide hydrogels for affinity‐controlled release of therapeutic cargo: Current and potential strategies
Peptide hydrogels for affinity‐controlled release of therapeutic cargo: Current and potential strategies
The development of devices for the precise and controlled delivery of therapeutics has grown rapidly over the last few dec...
Structural and functional swapping of amyloidogenic and antimicrobial peptides: Redefining the role of amyloidogenic propensity in disease and host defense
Structural and functional swapping of amyloidogenic and antimicrobial peptides: Redefining the role of amyloidogenic propensity in disease and host defense
Peptides constitute an essential component of all organisms' protein homeostasis ranging from bacteria, plants, and animal...
Design, synthesis, and evaluation of the self‐assembled antimicrobial peptides based on the ovalbumin‐derived peptide TK913
Design, synthesis, and evaluation of the self‐assembled antimicrobial peptides based on the ovalbumin‐derived peptide TK913
The preparation, self-assembly, and antimicrobial activity of peptides based on TK913 is described. TK9Z4 incorporating a ...
Secondary structures, dynamics, and DNA binding of the homeodomain of human SIX1
Secondary structures, dynamics, and DNA binding of the homeodomain of human SIX1
Human sine oculis homeobox homolog (SIX) 1 contains a homeodomain (HD), which is important for binding to DNA. In this stu...
Clearance of oxytocin and its potentially enzyme resistant analogues in the OXT‐receptor compartment of the potassium depolarized rat myometrium
Clearance of oxytocin and its potentially enzyme resistant analogues in the OXT‐receptor compartment of the potassium depolarized rat myometrium
The time–response behaviour of a group of oxytocin analogues structurally modified on potential sites of oxytocin s...
Tryptophan‐cardanol fluorescent nanoparticles inhibit α‐synuclein aggregation and disrupt amyloid fibrils
Tryptophan‐cardanol fluorescent nanoparticles inhibit α‐synuclein aggregation and disrupt amyloid fibrils
Protein misfolding and aggregation play a vital role in several human diseases such as Parkinson's, Alzheimer's, and prion...
Solid phase diversity‐oriented lysine modification of cyclic peptides
Solid phase diversity‐oriented lysine modification of cyclic peptides
Herein, we report a novel strategy for diversity-oriented lysine modification of cyclic peptides based on the orthogonal a...
The life and work of Robert (Bob) C. Sheppard
The life and work of Robert (Bob) C. Sheppard
The life and work of Robert Charles Sheppard (1932–2019), Bob Sheppard informally among friends, is outlined. He wa...
FITC characterization of a cathepsin B‐responsive nanoprobe for report of differentiation of HL60 cells into macrophages
FITC characterization of a cathepsin B‐responsive nanoprobe for report of differentiation of HL60 cells into macrophages
A cathepsin B (Cat B)-responsive optical nanoprobe is designed and prepared for report of HL60 differentiation into macrop...
Biophysical study of the structure and dynamics of the antimicrobial peptide maximin 1
Biophysical study of the structure and dynamics of the antimicrobial peptide maximin 1
Abstract Maximin 1 is a cationic, amphipathic antimicrobial peptide found in the skin secretions and brains of the Chinese...
Self‐assembling systems comprising intrinsically disordered protein polymers like elastin‐like recombinamers
Self‐assembling systems comprising intrinsically disordered protein polymers like elastin‐like recombinamers
Despite lacking cooperatively folded structures under native conditions, numerous intrinsically disordered proteins (IDPs)...
DIC/Oxyma‐based accelerated synthesis and oxidative folding studies of centipede toxin RhTx
DIC/Oxyma‐based accelerated synthesis and oxidative folding studies of centipede toxin RhTx
Coupling reagents play crucial roles in the iterative construction of amide bonds for the synthesis of peptides and peptid...
Chemical approaches for the preparation of ubiquitinated proteins via natural linkages
Chemical approaches for the preparation of ubiquitinated proteins via natural linkages
Ubiquitination is an important posttranslation modification (PTM) that regulates a variety of cellular processes, includin...
Safety‐catch linkers for Fmoc solid‐phase synthesis of peptide thioesters and hydrazides by amide‐to‐imide activation
Safety‐catch linkers for Fmoc solid‐phase synthesis of peptide thioesters and hydrazides by amide‐to‐imide activation
The use of C-terminal peptide thioesters and hydrazides in synthetic protein chemistry has inspired the search for optimal...
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