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The world’s first CRISPR therapy is approved: who will receive it?
The go-ahead for Vertex’s gene editing therapy in sickle cell disease and β-thalassemia is a historic milestone, but this ...
Tracing the fate of AAV vectors in the body
Tracing the fate of AAV vectors in the body
A study of AAV gene therapy in monkeys proposes that integrated vectors may drive long-term transgene expression.
DNA nanodevices map intracellular ions
DNA nanodevices map intracellular ions
Two DNA nanodevices, RatiNa and pHlicker, provide precise mapping of sodium levels in acidic organelles and potassium acti...
Top ten news stories in 2023
Our ranking is out, and it has a few surprises. In pole position — predictably — is Wegovy, the weight-slashin...
Encapsulated stem cell–derived β cells exert glucose control in patients with type 1 diabetes
Encapsulated stem cell–derived β cells exert glucose control in patients with type 1 diabetes
Clinical studies on the treatment of type 1 diabetes with device-encapsulated pancreatic precursor cells derived from huma...
Spatial methods for microbiome–host interactions
Spatial methods for microbiome–host interactions
Spatial transcriptomics offers a glimpse of how microbiomes interact with their hosts.
Spatial host–microbiome sequencing reveals niches in the mouse gut
Spatial host–microbiome sequencing reveals niches in the mouse gut
Mucosal and barrier tissues, such as the gut, lung or skin, are composed of a complex network of cells and microbes formin...
Spatial metatranscriptomics resolves host–bacteria–fungi interactomes
Spatial metatranscriptomics resolves host–bacteria–fungi interactomes
The interactions of microorganisms among themselves and with their multicellular host take place at the microscale, formin...
Modeling human trunk development
Modeling human trunk development
A model of the embryonic human trunk attains a more mature developmental stage than previous models.
Antibiotic nanoparticles boost antitumor immunity
Antibiotic nanoparticles boost antitumor immunity
Liposomes loaded with antibiotics eliminate intracellular bacteria in a colorectal cancer model, unleashing antitumor T ce...
Generation of locus coeruleus norepinephrine neurons from human pluripotent stem cells
Generation of locus coeruleus norepinephrine neurons from human pluripotent stem cells
Central norepinephrine (NE) neurons, located mainly in the locus coeruleus (LC), are implicated in diverse psychiatric and...
A bacterial assist for CAR-T cells
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
Precise intraoperative brain tumor classification
Central nervous system (CNS) tumors are a leading cause of cancer-related deaths, particularly among children, and the pri...
Antibody engineering
Recent patents relating to the manufacture and design of engineered immunoglobulin polypeptides.
NKs for lupus poised for trial
Nkarta is charting a course for its allogeneic chimeric antigen receptor (CAR) natural killer cell (NK) therapy in autoimm...
Chan Zuckerberg hubs multiply
In October, the Chan Zuckerberg Initiative (CZI) launched two new biohubs: one in New York and another in Chicago. The bio...
Most effective malaria vaccine yet
A new malaria vaccine for children is the first to meet the World Health Organization’s (WHO) 75% protection target. The v...
Brain imaging turned inside out
Brain imaging turned inside out
Neural connectivity in brain tissue is imaged by labeling the extracellular space.
Systematic discovery of neoepitope–HLA pairs for neoantigens shared among patients and tumor types
Systematic discovery of neoepitope–HLA pairs for neoantigens shared among patients and tumor types
The broad application of precision cancer immunotherapies is limited by the number of validated neoepitopes that are commo...
Imaging glycosylated RNAs at the subcellular scale
Imaging glycosylated RNAs at the subcellular scale
A recently discovered RNA species on the cell surface is studied by proximity ligation.
AI for drug discovery is booming, but who owns the patents?
AI for drug discovery is booming, but who owns the patents?
Biopharma companies debate whether to patent their algorithms for finding medicines.
Compressed Perturb-seq enables highly efficient genetic screens
Compressed Perturb-seq enables highly efficient genetic screens
Using an experimental and computational framework inspired by compressed sensing, we greatly reduced the number of measure...
Hypoimmune cells resist rejection in monkeys
Hypoimmune cells resist rejection in monkeys
Genetic engineering to block immune destruction of transplanted cells succeeds in macaques.
Scalable genetic screening for regulatory circuits using compressed Perturb-seq
Scalable genetic screening for regulatory circuits using compressed Perturb-seq
Pooled CRISPR screens with single-cell RNA sequencing readout (Perturb-seq) have emerged as a key technique in functional ...
DNA writing technologies moving toward synthetic genomes
DNA writing technologies moving toward synthetic genomes
As new technologies hit the market, synthetic DNA is available faster and cheaper than ever before. Regulators are prepari...
Expanding access to CAR T cell therapies through local manufacturing
Expanding access to CAR T cell therapies through local manufacturing
Chimeric antigen receptor (CAR) T cells are changing the therapeutic landscape for hematological malignancies. To date, al...
Perfecting antibodies with language models
Perfecting antibodies with language models
A general-purpose protein language model rapidly improves antibody properties.
Sir Ian Wilmut 1944–2023
Sir Ian Wilmut 1944–2023
Ian Wilmut passed away on 10 September 2023 in his beloved Scotland. Ian was a prince of a person, gentle...
The chemistry of next-generation sequencing
The chemistry of next-generation sequencing
The first large genome fully sequenced by next-generation sequencing (NGS) was that of a bacteriophage using sequencing by...
Author Correction: Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning
Jeffrey A. Hussmann, Dian Yang, Joseph M. Replogle & Jonathan S. WeissmanPresent address: Whitehead Institute for Biom...
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