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A strategy to load, rethread and read protein sequences through a nanopore
Understanding proteomic diversity at the molecular level is essential for advances in biology and medicine, but sequencing...
Niemann–Pick double win
In one week, the US Food and Drug Administration approved two treatments for Niemann–Pick disease type C (NPC). One agent,...
T cells
Recent patents relating to the manufacture, preparation and use of T cells in treating cancer.
Cellular shuttles put mislocalized proteins in their right place
The misplacement of proteins within a cell can cause various diseases, but no therapeutic intervention can precisely contr...
Bispecific upstages Keytruda
The new bispecific drug ivonescimab has outperformed Merck’s blockbuster PD-1 checkpoint inhibitor Keytruda (pembrolizumab...
From Bench to Podcast: Chloe Fishman
From Bench to Podcast: Chloe Fishman
Join us as Cláudia and Chloe touch bases on the advantages of this tool over existing methods, discuss the relevance of ph...
Pan-KRAS destruction with a single PROTAC
Most small-molecule drugs that target oncogenic Kirsten rat sarcoma virus (KRAS) mutants rely on interactions with variant...
An antigen discovery pipeline integrates multi-omics data and informs immunotherapy
An antigen discovery pipeline integrates multi-omics data and informs immunotherapy
We developed NeoDisc, a computational antigen discovery pipeline that integrates multi-omics data, including genomics, tra...
Model-directed generation of artificial CRISPR–Cas13a guide RNA sequences improves nucleic acid detection
Model-directed generation of artificial CRISPR–Cas13a guide RNA sequences improves nucleic acid detection
CRISPR guide RNA sequences deriving exactly from natural sequences may not perform optimally in every application. Here we...
A comprehensive proteogenomic pipeline for neoantigen discovery to advance personalized cancer immunotherapy
A comprehensive proteogenomic pipeline for neoantigen discovery to advance personalized cancer immunotherapy
The accurate identification and prioritization of antigenic peptides is crucial for the development of personalized cancer...
A community effort to optimize sequence-based deep learning models of gene regulation
A community effort to optimize sequence-based deep learning models of gene regulation
A systematic evaluation of how model architectures and training strategies impact genomics model performance is needed. To...
Author Correction: The cost of drug patent expiration date errors
Authors and AffiliationsProgram On Regulation, Therapeutics And Law (PORTAL), Division of Pharmacoepidemiology and Pharmac...
Rapid species-level metagenome profiling and containment estimation with sylph
Rapid species-level metagenome profiling and containment estimation with sylph
Profiling metagenomes against databases allows for the detection and quantification of microorganisms, even at low abundan...
One-step nanoscale expansion microscopy reveals individual protein shapes
One-step nanoscale expansion microscopy reveals individual protein shapes
The attainable resolution of fluorescence microscopy has reached the subnanometer range, but this technique still fails to...
A circularly permuted CasRx platform for efficient, site-specific RNA editing
A circularly permuted CasRx platform for efficient, site-specific RNA editing
Inactive Cas13 orthologs have been fused to a mutant human ADAR2 deaminase domain at the C terminus to enable programmable...
Author Correction: Efficient genetic code expansion without host genome modifications
Authors and AffiliationsDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA, USAAlan Costello, Alexander...
Advances in optical pooled screening to map spatial complexity
Advances in optical pooled screening to map spatial complexity
Two major advances in optical pooled screening improve substantially on sensitivity and robustness, expanding its applicab...
Publisher Correction: Multistate and functional protein design using RoseTTAFold sequence space diffusion
These authors contributed equally: Sidney Lyayuga Lisanza, Jacob Merle Gershon, Samuel W. K. Tipps, Jeremiah Nelson Sims, ...
A framework for expanding discovery efforts with compressed phenotypic screens
A framework for expanding discovery efforts with compressed phenotypic screens
Sample, financial and labor requirements are key barriers to scaling up high-content phenotypic discovery efforts. A broad...
A CRISPR-based method for detecting mRNA in extracellular vesicles
A CRISPR-based method for detecting mRNA in extracellular vesicles
A CRISPR-based assay both recognizes and amplifies target mRNA, achieving sub-attomolar sensitivity with single-nucleotide...
Scalable, compressed phenotypic screening using pooled perturbations
Scalable, compressed phenotypic screening using pooled perturbations
High-throughput phenotypic screens using biochemical perturbations and high-content readouts are constrained by limitation...
AI meets real-world patients
The time has come for biotech companies to embrace machine learning for clinical trials, but they should start with compil...
Mapping multimodal phenotypes to perturbations in cells and tissue with CRISPRmap
Mapping multimodal phenotypes to perturbations in cells and tissue with CRISPRmap
Unlike sequencing-based methods, which require cell lysis, optical pooled genetic screens enable investigation of spatial ...
Bacteria displaying cytokines heat up the tumor microenvironment
Bacteria displaying cytokines heat up the tumor microenvironment
Escherichia coli engineered to display cytokines destroy hard-to-treat tumors by boosting the activity of local native and...
Non-pathogenic E. coli displaying decoy-resistant IL18 mutein boosts anti-tumor and CAR NK cell responses
Non-pathogenic E. coli displaying decoy-resistant IL18 mutein boosts anti-tumor and CAR NK cell responses
The tumor microenvironment can inhibit the efficacy of cancer therapies through mechanisms such as poor trafficking and ex...
TCR cell therapies vanquish solid tumors — finally
TCR cell therapies vanquish solid tumors — finally
The FDA’s approval of the first genetically modified T cell therapy for treating a rare sarcoma is paving the way fo...
Rapid generation of long, chemically modified pegRNAs for prime editing
Rapid generation of long, chemically modified pegRNAs for prime editing
The editing efficiencies of prime editing (PE) using ribonucleoprotein (RNP) and RNA delivery are not optimal due to the c...
Multistate and functional protein design using RoseTTAFold sequence space diffusion
Multistate and functional protein design using RoseTTAFold sequence space diffusion
Protein denoising diffusion probabilistic models are used for the de novo generation of protein backbones but are limited ...
Increasing intracellular dNTP levels improves prime editing efficiency
Increasing intracellular dNTP levels improves prime editing efficiency
In primary cell types, intracellular deoxynucleotide triphosphate (dNTP) levels are tightly regulated in a cell cycle-depe...
Coordinated, multicellular patterns of transcriptional variation that stratify patient cohorts are revealed by tensor decomposition
Coordinated, multicellular patterns of transcriptional variation that stratify patient cohorts are revealed by tensor decomposition
Tissue-level and organism-level biological processes often involve the coordinated action of multiple distinct cell types....
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