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Pompe disease treated before birth
Pompe disease treated before birth
For the first time, clinicians have successfully treated a fetus in utero with enzyme replacement therapy (ERT). A team of...
Genotoxins from gut bacteria
Small-molecule metabolites from the gut microbiota might contribute to the progression of colorectal cancer (CRC) via DNA ...
Biomedical imaging
Recent patents relating to methods and devices for improved imaging in the biomedical field.
Imaging epigenomics in the brain
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
Noma: from grasshopper brews to age-old ‘garum’
Noma: from grasshopper brews to age-old ‘garum’
The idea began with Noma co-founder René Redzepi’s incursions into eating insects. Grasshopper exoskeletons, the chefs fou...
Big mRNA players focus on flu vaccines
Big mRNA players focus on flu vaccines
Pfizer and BioNTech’s mRNA vaccine for influenza and COVID-19 began phase 1 trials in November, joining the growing number...
Alzheimer’s space heats up
Alzheimer’s space heats up
Gantenerumab didn’t improve cognitive decline in two trials that followed 2,000 people for over 2 years. Patients treated ...
Author Correction: m6A RNA modifications are measured at single-base resolution across the mammalian transcriptome
Author Correction: m6A RNA modifications are measured at single-base resolution across the mammalian transcriptome
These authors contributed equally: Lulu Hu, Shun Liu, Yong Peng, Ruiqi Ge, Rui Su.These authors jointly supervised this wo...
Selective knockout of gut bacteria
Discover the world’s best science and medicine | Nature.com
Enhancing seed protein content
Discover the world’s best science and medicine | Nature.com
Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-directed integrases
Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-directed integrases
Programmable genome integration of large, diverse DNA cargo without DNA repair of exposed DNA double-strand breaks remains...
CRISPR-associated proteases as RNA sensors
Discover the world’s best science and medicine | Nature.com
Author Correction: Modular, programmable RNA sensing using ADAR editing in living cells
Authors and AffiliationsDepartment of Bioengineering, Stanford University, Stanford, CA, USAK. Eerik Kaseniit & Natali...
Author Correction: Engineering the amoeba Dictyostelium discoideum for biosynthesis of a cannabinoid precursor and other polyketides
Author notesThese authors contributed equally: Christin Reimer, Johann E. Kufs.Authors and AffiliationsEvolution of Microb...
Novel recombinases for large DNA insertions
Novel recombinases for large DNA insertions
Bioinformatic mining and engineering of serine recombinases yields improved genome editing tools.
Single-cell multi-omics allows functional characterization of structural variants
Single-cell multi-omics allows functional characterization of structural variants
We developed a computational method based on Strand-seq that combines nucleosome occupancy and structural variation analys...
Healing chronic wounds with a wireless smart bandage with integrated sensors and stimulators
Healing chronic wounds with a wireless smart bandage with integrated sensors and stimulators
We developed a wireless smart bandage with sensors that can detect the condition of a wound and stimulators that can deliv...
Functional analysis of structural variants in single cells using Strand-seq
Functional analysis of structural variants in single cells using Strand-seq
Somatic structural variants (SVs) are widespread in cancer, but their impact on disease evolution is understudied due to a...
Wireless, closed-loop, smart bandage with integrated sensors and stimulators for advanced wound care and accelerated healing
Wireless, closed-loop, smart bandage with integrated sensors and stimulators for advanced wound care and accelerated healing
‘Smart’ bandages based on multimodal wearable devices could enable real-time physiological monitoring and acti...
Rapid mining of (meta)genomic biodiversity by repurposing CRISPRi for positive selection
Rapid mining of (meta)genomic biodiversity by repurposing CRISPRi for positive selection
The global microbiota contains an enormous, previously inaccessible reservoir of biodiversity that can now be captured as ...
High-throughput retrieval of target sequences from complex clone libraries using CRISPRi
High-throughput retrieval of target sequences from complex clone libraries using CRISPRi
The capture of metagenomic DNA in large clone libraries provides the opportunity to study microbial diversity that is inac...
The lysosomal degraders
The lysosomal degraders
Inspired by PROTACs, new degraders are emerging that harness endocytosis and autophagy to send a wide array of targets to ...
Improving combination drug trials using ‘definitive screening designs’
Strohbehn, G. W., Kacew, A. J., Goldstein, D. A., Feldman, R. C. & Ratain, M. J. Nat. Biotechnol. 39, 1504–1510 (2021)...
An engineered T7 RNA polymerase that produces mRNA free of immunostimulatory byproducts
An engineered T7 RNA polymerase that produces mRNA free of immunostimulatory byproducts
In vitro transcription (IVT) is a DNA-templated process for synthesizing long RNA transcripts, including messenger RNA (mR...
Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing
Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing
Cytosine base editors (CBEs) efficiently generate precise C·G-to-T·A base conversions, but the activation-induce...
Evolution of an adenine base editor into a small, efficient cytosine base editor with low off-target activity
Evolution of an adenine base editor into a small, efficient cytosine base editor with low off-target activity
Cytosine base editors (CBEs) are larger and can suffer from higher off-target activity or lower on-target editing efficien...
First allo T cell gets European nod
First allo T cell gets European nod
Ebvallo works by targeting and eliminating EBV-infected cells in immunocompromised patients who lack sufficient T cells to...
Spatial transcriptomics with light barcodes in intact tissues
Spatially resolved omics aim to integrate distinct molecular states with the spatial context of single cells within comple...
Single-cell RNA-seq relates GWAS variants to disease risk
While genome-wide association studies (GWAS) have identified thousands of variants associated with disease, elucidating th...
UK Biobank’s reimaging colossus
UK Biobank’s reimaging colossus
This largest longitudinal repeat imaging study of its kind will be particularly useful for neurodegenerative disease. Seri...