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Why Japan lacks a vibrant biotech industry
Recent analysis of the biopharmaceutical industry in Japan has emphasized that the lack of a thriving biotech ecosystem in...
RoseTTAFold expands to all-atom for biomolecular prediction and design
Deep learning methods enable the structural prediction of proteins with high accuracy but are unable to model non-protein ...
Customized molecular glue complexes with desired properties
Degron tags can trigger rapid and temporally controlled degradation of proteins using small molecules known as molecular g...
World’s priciest drug treats MLD
The US Food and Drug Administration has approved the first therapy for metachromatic leukodystrophy (MLD), a rare fatal ge...
Saving Cavendish
Saving Cavendish
Farmers have a green light to grow the first genetically modified banana. The wilt-proof strain of the Cavendish banana de...
Prime editing
Recent patents relating to methods and compositions for prime editing.
FDA approves first MASH drug
The first drug to treat fatty liver disease due to metabolic dysfunction-associated steatohepatitis (MASH) has been given ...
First gene-edited pig kidney transplant
Surgeons at Massachusetts General Hospital have transplanted a pig kidney into a living person for the first time. On 16 M...
Improving microbial phylogeny with citizen science within a mass-market video game
Improving microbial phylogeny with citizen science within a mass-market video game
Citizen science video games are designed primarily for users already inclined to contribute to science, which severely lim...
Inferring gene regulatory networks from single-cell multiome data using atlas-scale external data
Inferring gene regulatory networks from single-cell multiome data using atlas-scale external data
Existing methods for gene regulatory network (GRN) inference rely on gene expression data alone or on lower resolution bul...
Genome engineering with Cas9 and AAV repair templates generates frequent concatemeric insertions of viral vectors
Genome engineering with Cas9 and AAV repair templates generates frequent concatemeric insertions of viral vectors
CRISPR–Cas9 paired with adeno-associated virus serotype 6 (AAV6) is among the most efficient tools for producing tar...
Gene trajectory inference for single-cell data by optimal transport metrics
Gene trajectory inference for single-cell data by optimal transport metrics
Single-cell RNA sequencing has been widely used to investigate cell state transitions and gene dynamics of biological proc...
Genetically encoding colors and images into bioengineered microbial materials
Genetically encoding colors and images into bioengineered microbial materials
Using synthetic biology, we engineered a cellulose-producing bacterium that can produce eumelanin and respond to light, so...
Capturing and modeling cellular niches from dissociated single-cell and spatial data
Capturing and modeling cellular niches from dissociated single-cell and spatial data
Cells interact with their local environment to enact global tissue function. By harnessing gene–gene covariation in ...
Self-pigmenting textiles grown from cellulose-producing bacteria with engineered tyrosinase expression
Self-pigmenting textiles grown from cellulose-producing bacteria with engineered tyrosinase expression
Environmental concerns are driving interest in postpetroleum synthetic textiles produced from microbial and fungal sources...
The covariance environment defines cellular niches for spatial inference
The covariance environment defines cellular niches for spatial inference
A key challenge of analyzing data from high-resolution spatial profiling technologies is to suitably represent the feature...
The potential of DAOs for funding and collaborative development in the life sciences
The potential of DAOs for funding and collaborative development in the life sciences
VitaDAO funds longevity research through a blockchain-based decentralized autonomous organization (DAO), showcasing the po...
Antivenom slithers back to life
Snakebite treatment still relies on antivenom, a 130-year old technology, but biotech is on the job.
Author Correction: Tumor immunotherapy across MHC barriers using allogeneic T-cell precursors
Department Immunology, Memorial Sloan-Kettering Cancer Center, New York, New York, USAJohannes L. Zakrzewski, David Suh, O...
De novo and somatic structural variant discovery with SVision-pro
De novo and somatic structural variant discovery with SVision-pro
Long-read-based de novo and somatic structural variant (SV) discovery remains challenging, necessitating genomic compariso...
Branched chemically modified poly(A) tails enhance the translation capacity of mRNA
Branched chemically modified poly(A) tails enhance the translation capacity of mRNA
Although messenger RNA (mRNA) has proved effective as a vaccine, its potential as a general therapeutic modality is limite...
Starfysh integrates spatial transcriptomic and histologic data to reveal heterogeneous tumor–immune hubs
Starfysh integrates spatial transcriptomic and histologic data to reveal heterogeneous tumor–immune hubs
Spatially resolved gene expression profiling provides insight into tissue organization and cell–cell crosstalk; howe...
Making genome editing a success story in Africa
Making genome editing a success story in Africa
International Livestock Research Institute (ILRI), Nairobi, KenyaHussein M. AbkalloWits/SAMRC Antiviral Gene Therapy Resea...
A retrotransposon for site-specific gene transfer
A retrotransposon for site-specific gene transfer
An engineered retrotransposon achieves targeted gene transfer into the human genome.
Wearable technology and devices
Recent patents relating to wearable technology and devices for patient monitoring and treatment of health conditions.
Supercharging T cell therapy with cancer mutations
T cell therapies are still hindered by poor T cell persistence and function, making them largely ineffective against solid...
US bill targets Chinese biotechs
The United States is seeking to prevent four Chinese biotech companies from doing business in the country, citing them as ...
A synthetic antibiotic overcomes antimicrobial resistance
Many small-molecule antibiotics function by disrupting bacterial ribosomes, but bacteria develop resistance by modifying r...
In vivo CRISPR agent cuts HAE attacks 95%
A CRISPR–Cas9-based gene editing therapy from Intellia Therapeutics reduced monthly swelling attacks by 95% in people with...
World’s first TIL therapy approved
Iovance Biotherapeutics has received a long-awaited go-ahead from the US Food and Drug Administration for its tumor-infilt...
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