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NIS-Seq enables cell-type-agnostic optical perturbation screening
NIS-Seq enables cell-type-agnostic optical perturbation screening
Optical pooled screening offers a broader-scale alternative to enrichment-based perturbation screening, using fluorescence...
Toward a safer and more secure US bioeconomy
To enhance the safety and security of the US bioeconomy, a new public–private partnership should be established to f...
The devolution of biosimilars regulations
After two decades of experience with biosimilars, physicochemical and in vitro biological comparison with their reference ...
CRISPR-StAR enables high-resolution genetic screening in complex in vivo models
CRISPR-StAR enables high-resolution genetic screening in complex in vivo models
Pooled genetic screening with CRISPR–Cas9 has enabled genome-wide, high-resolution mapping of genes to phenotypes, b...
Plant bling: cellulose that sparkles
Plant bling: cellulose that sparkles
Plant-based glitter with sustainable credentials has arrived. Cambridge, UK–...
A synthetic scaffold to target peptide–MHC complexes
A synthetic scaffold to target peptide–MHC complexes
A method for designing high-affinity, specific binders to peptide–MHC complexes may improve the next generation of a...
Targeting peptide antigens using a multiallelic MHC I-binding system
Targeting peptide antigens using a multiallelic MHC I-binding system
Identifying highly specific T cell receptors (TCRs) or antibodies against epitopic peptides presented by class I major his...
A general system for targeting MHC class II–antigen complex via a single adaptable loop
A general system for targeting MHC class II–antigen complex via a single adaptable loop
Major histocompatibility complex class II (MHCII) bound to a peptide antigen mediates interactions between CD4+ T cells an...
Biopharma deals get smaller and earlier
Biopharma deals get smaller and earlier
Merger and acquisition activity is at a seven-year low in 2024 as buyers digest prior deals and US election jitters delaye...
Evo learns biological complexity from the molecular to genome scale
Generative artificial intelligence models of molecular biology are often restricted to individual molecules or DNA segment...
Base editing boosts hemoglobin in sickle cell disease
Beam Therapeutics’ early clinical data on its base-editing therapy BEAM-101 shows for the first time that the technology r...
Stem cells
Recent patents relating to compositions, methods of preparation and use of stem cells.
CRISPR unlocks a sweet tomato that keeps its size
The domestication of tomato (Solanum lycopersicum) has led to a massive increase in fruit size but at the cost of decrease...
Discovering the crucial function of long noncoding RNAs
The human genome contains thousands of long noncoding RNAs (lncRNAs), of which very few have been linked to a functional r...
BioNTech boosts oncology pipeline with China buy
One year after partnering with clinical-stage Biotheus on a bispecific antibody targeting PD-L1 and VEGF-A, BioNTech annou...
An update on Cuban biotech
Cuba provides a rare example of a publicly owned biotech sector in a low-income country. Since its founding in 1986, Cuba’...
Ovarian tumor cells gain competitive advantage by actively reducing the cellular fitness of microenvironment cells
Ovarian tumor cells gain competitive advantage by actively reducing the cellular fitness of microenvironment cells
Cell competition and fitness comparison between cancer and tumor microenvironment (TME) cells determine oncogenic fate. Ou...
Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy
Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy
Ionizable lipids are a key component of lipid nanoparticles, the leading nonviral messenger RNA delivery technology. Here,...
Challenges for developing broad-based mucosal vaccines for respiratory viruses
Challenges for developing broad-based mucosal vaccines for respiratory viruses
Graham, B. S. & Sullivan, N. J. Nat. Immunol. 19, 20–28 (2018).Article  CAS  PubMed  ...
Engineered platelets as targeted protein degraders and application to breast cancer models
Engineered platelets as targeted protein degraders and application to breast cancer models
Clinical application of chimeric molecules for targeted protein degradation has been limited by unfavorable drug-like prop...
Proteolytic platelets as targeted protein degraders
Proteolytic platelets as targeted protein degraders
Proteolytic chimeras constructed from various bioactive modules can degrade either cytoplasmic or extracellular proteins, ...
Top ten news stories in 2024
From mRNA drugs and the Achilles heel of obesity drugs, to single-cell biology and foundation models for drug discovery, t...
2024: research in review
Nature Biotechnology editors pick their favorite research articles from 2024.
Biology and applications of CRISPR–Cas12 and transposon-associated homologs
Biology and applications of CRISPR–Cas12 and transposon-associated homologs
CRISPR-associated Cas12 proteins are a highly variable collection of nucleic acid-targeting proteins. All Cas12 variants u...
Response to ‘Why Japan lacks a vibrant biotech industry’
In their April article, Mark Kessel and Chris Vickrey raise several valid concerns about the Japanese life sciences indust...
Intravenous administration of blood–brain barrier-crossing conjugates facilitate biomacromolecule transport into central nervous system
Intravenous administration of blood–brain barrier-crossing conjugates facilitate biomacromolecule transport into central nervous system
Delivery of biomacromolecules to the central nervous system (CNS) remains challenging because of the restrictive nature of...
Recovery of biological signals lost in single-cell batch integration with CellANOVA
Recovery of biological signals lost in single-cell batch integration with CellANOVA
Data integration to align cells across batches has become a cornerstone of single-cell data analysis, critically affecting...
Genome editing with the HDR-enhancing DNA-PKcs inhibitor AZD7648 causes large-scale genomic alterations
Genome editing with the HDR-enhancing DNA-PKcs inhibitor AZD7648 causes large-scale genomic alterations
The DNA-PKcs inhibitor AZD7648 enhances CRISPR–Cas9-directed homology-directed repair efficiencies, with potential f...
Lipid nanoparticle-mediated mRNA delivery to CD34+ cells in rhesus monkeys
Lipid nanoparticle-mediated mRNA delivery to CD34+ cells in rhesus monkeys
Transplantation of ex vivo engineered hematopoietic stem cells (HSCs) can lead to robust clinical responses but carries ri...
Editor’s pick: Gate Bioscience
Editor’s pick: Gate Bioscience
Each year, Nature Biotechnology highlights companies that have received sizeable early-stage funding in the previous year....
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