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Author Correction: Precision targeting of autoantigen-specific B cells in muscle-specific tyrosine kinase myasthenia gravis with chimeric autoantibody receptor T cells
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
A bacterial neoantigen cancer vaccine
Neoantigen cancer vaccines hold great promise for cancer treatment but are often limited by the immunosuppressive tumor en...
First proof-of-mechanism for RNA editing in humans
The first clinical results for an RNA-editing oligonucleotide designed to correct a disease-causing single-base mutation i...
Shot in the arm for biotech fuels
The US Department of Energy (DOE) in October conditionally committed nearly $3 billion to two companies to scale up the pr...
Cancer cases in bluebird’s gene therapy trials
Over 10% of patients with a fatal neurodegenerative disease who received bluebird bio’s FDA-approved gene therapy Skysona ...
From Bench to Podcast: Ali Shaib
From Bench to Podcast: Ali Shaib
In this episode, Associate Editor Cláudia Vilhena sits down with Ali Shaib, the lead author of an exciting new study showc...
Wasp gut microbes yield beer with extra tang
Wasp gut microbes yield beer with extra tang
Beer lovers can now enjoy their wildest drink yet thanks to a yeast carried by wasps. AB Biotek from Peterborough in the U...
Directed evolution of engineered virus-like particles with improved production and transduction efficiencies
Directed evolution of engineered virus-like particles with improved production and transduction efficiencies
Engineered virus-like particles (eVLPs) are promising vehicles for transient delivery of proteins and RNAs, including gene...
Amyloid is everywhere, but new treatments could stop the toxic build up
Amyloid is everywhere, but new treatments could stop the toxic build up
Amyloid deposits are present in the brains of cognitively impaired individuals, but also accumulate throughout the body. S...
Italy tests first gene-edited vines for winemaking
Italy tests first gene-edited vines for winemaking
Europe’s first field trial of gene-edited vines began in northern Italy on 30 September 2024. Developed by EdiVite, ...
Development of compact transcriptional effectors using high-throughput measurements in diverse contexts
Development of compact transcriptional effectors using high-throughput measurements in diverse contexts
Transcriptional effectors are protein domains known to activate or repress gene expression; however, a systematic understa...
CRISPR Nobelists surrender their own European patents
CRISPR Nobelists surrender their own European patents
A strategic move by lawyers acting for Doudna and Charpentier is the latest twist in the battleground for CRISPR–Cas...
What will it take to get miRNA therapies to market?
The Nobel Prize in medicine was awarded for the discovery of miRNA, but miRNA therapeutics have a long way to go before th...
AIntibody: an experimentally validated in silico antibody discovery design challenge
AIntibody: an experimentally validated in silico antibody discovery design challenge
The challenges proposed in this inaugural competition are based on unpublished SARS-CoV-2 next-generation sequencing (NGS)...
Binary vector copy number engineering improves Agrobacterium-mediated transformation
Binary vector copy number engineering improves Agrobacterium-mediated transformation
The copy number of a plasmid is linked to its functionality, yet there have been few attempts to optimize higher-copy-numb...
Site-specific drug release of monomethyl fumarate to treat oxidative stress disorders
Site-specific drug release of monomethyl fumarate to treat oxidative stress disorders
Treatment of diseases of oxidative stress through activation of the antioxidant nuclear factor E2-related factor 2 (NRF2) ...
Ancient and versatile CRISPR–Cas nuclease created with ancestral sequence reconstruction
Ancient and versatile CRISPR–Cas nuclease created with ancestral sequence reconstruction
Ancestral sequence reconstruction enables the identification and synthesis of ReChb, an ancient form of CRISPR–Cas12...
Comprehensive genome analysis and variant detection at scale using DRAGEN
Comprehensive genome analysis and variant detection at scale using DRAGEN
Research and medical genomics require comprehensive, scalable methods for the discovery of novel disease targets, evolutio...
A resurrected ancestor of Cas12a expands target access and substrate recognition for nucleic acid editing and detection
A resurrected ancestor of Cas12a expands target access and substrate recognition for nucleic acid editing and detection
The properties of Cas12a nucleases constrict the range of accessible targets and their applications. In this study, we app...
A structurally informed human protein–protein interactome reveals proteome-wide perturbations caused by disease mutations
A structurally informed human protein–protein interactome reveals proteome-wide perturbations caused by disease mutations
To assist the translation of genetic findings to disease pathobiology and therapeutics discovery, we present an ensemble d...
Gold-siRNA supraclusters enhance the anti-tumor immune response of stereotactic ablative radiotherapy at primary and metastatic tumors
Gold-siRNA supraclusters enhance the anti-tumor immune response of stereotactic ablative radiotherapy at primary and metastatic tumors
Strategies to enhance the anti-tumor immune response of stereotactic ablative radiotherapy (SABR) at primary tumors and ab...
Pest control gets the CRISPR treatment
Pest control gets the CRISPR treatment
Precision genetic methods are enabling more efficient, environmentally friendly pest control methods for agricultural use ...
Droplet Hi-C enables scalable, single-cell profiling of chromatin architecture in heterogeneous tissues
Droplet Hi-C enables scalable, single-cell profiling of chromatin architecture in heterogeneous tissues
Current methods for analyzing chromatin architecture are not readily scalable to heterogeneous tissues. Here we introduce ...
Lung and liver editing by lipid nanoparticle delivery of a stable CRISPR–Cas9 ribonucleoprotein
Lung and liver editing by lipid nanoparticle delivery of a stable CRISPR–Cas9 ribonucleoprotein
Lipid nanoparticle (LNP) delivery of clustered regularly interspaced short palindromic repeat (CRISPR) ribonucleoproteins ...
Global profiling of protein complex dynamics with an experimental library of protein interaction markers
Global profiling of protein complex dynamics with an experimental library of protein interaction markers
Methods to systematically monitor protein complex dynamics are needed. We introduce serial ultrafiltration combined with l...
A strategy to load, rethread and read protein sequences through a nanopore
Understanding proteomic diversity at the molecular level is essential for advances in biology and medicine, but sequencing...
Niemann–Pick double win
In one week, the US Food and Drug Administration approved two treatments for Niemann–Pick disease type C (NPC). One agent,...
T cells
Recent patents relating to the manufacture, preparation and use of T cells in treating cancer.
Cellular shuttles put mislocalized proteins in their right place
The misplacement of proteins within a cell can cause various diseases, but no therapeutic intervention can precisely contr...
Bispecific upstages Keytruda
The new bispecific drug ivonescimab has outperformed Merck’s blockbuster PD-1 checkpoint inhibitor Keytruda (pembrolizumab...
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