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Inferring cell–cell communication at single-cell resolution
Inferring cell–cell communication at single-cell resolution
Existing methods to infer cell–cell communication from single-cell RNA-sequencing data fail to leverage the full inf...
Can microbes save the planet?
Genetic engineering and accelerated evolution of microbes aim to help climate change.
Integration of multi-modal single-cell data
Integration of multi-modal single-cell data
Single-cell data from RNA-seq, chromatin accessibility, DNA methylation and other modalities can be readily integrated usi...
Stabilized mosaic single-cell data integration using unshared features
Stabilized mosaic single-cell data integration using unshared features
Currently available single-cell omics technologies capture many unique features with different biological information cont...
Dictionary learning for integrative, multimodal and scalable single-cell analysis
Dictionary learning for integrative, multimodal and scalable single-cell analysis
Mapping single-cell sequencing profiles to comprehensive reference datasets provides a powerful alternative to unsupervise...
Sequencing by avidity enables high accuracy with low reagent consumption
Sequencing by avidity enables high accuracy with low reagent consumption
We present avidity sequencing, a sequencing chemistry that separately optimizes the processes of stepping along a DNA temp...
An engineered influenza virus to deliver antigens for lung cancer vaccination
An engineered influenza virus to deliver antigens for lung cancer vaccination
The development of cancer neoantigen vaccines that prime the anti-tumor immune responses has been hindered in part by chal...
Phage-inclusive profiling of human gut microbiomes with Phanta
Phage-inclusive profiling of human gut microbiomes with Phanta
Due to technical limitations, most gut microbiome studies have focused on prokaryotes, overlooking viruses. Phanta, a viro...
CRISPR-free, strand-selective mitochondrial DNA base editing using a nickase
CRISPR-free, strand-selective mitochondrial DNA base editing using a nickase
The fusion of a programmable transcription-activator-like effector (TALE) protein with a nickase, in conjunction with a de...
Combining reference genomes into a pangenome graph improves accuracy and reduces bias
Combining reference genomes into a pangenome graph improves accuracy and reduces bias
Minigraph-Cactus, a method to efficiently combine multiple reference genome assemblies into a pangenome reference graph, c...
Plant molecular farming in the wake of the closure of Medicago Inc
Plant molecular farming in the wake of the closure of Medicago Inc
Plant molecular farming, which includes the production of recombinant proteins and small molecules using ...
Spatial imaging of glycoRNA in single cells with ARPLA
Spatial imaging of glycoRNA in single cells with ARPLA
Little is known about the biological roles of glycosylated RNAs (glycoRNAs), a recently discovered class of glycosylated m...
A fully integrated wearable ultrasound system to monitor deep tissues in moving subjects
A fully integrated wearable ultrasound system to monitor deep tissues in moving subjects
Recent advances in wearable ultrasound technologies have demonstrated the potential for hands-free data acquisition, but t...
Strand-selective base editing of human mitochondrial DNA using mitoBEs
Strand-selective base editing of human mitochondrial DNA using mitoBEs
A number of mitochondrial diseases in humans are caused by point mutations that could be corrected by base editors, but de...
Forum: Alexandrov and Le
Forum: Alexandrov and Le
Share this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a sh...
Bespoke protein delivery via bacterial injection systems
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
Transposon–gene chimeras move up as cancer epitopes
Transposons are known to sometimes act as alternative promoters for genes, but their reactivation due to epigenetic change...
Elizabeth Holmes prison delayed
The disgraced founder of sham blood testing company Theranos is appealing a court ruling that requires her to report to pr...
How the Monty Hall problem is similar to the false discovery rate in high-throughput data analysis
How the Monty Hall problem is similar to the false discovery rate in high-throughput data analysis
The author appreciates comments and feedback from Wei Li at the University of California, Irvine, Chongzhi Zang at the Uni...
Subtle cell states resolved in single-cell data
Subtle cell states resolved in single-cell data
SEACells identifies rare cell states in large datasets, enabling atlas-scale studies.
Selection by essential-gene exon knock-in for the generation of efficient cell therapies
Selection by essential-gene exon knock-in for the generation of efficient cell therapies
By linking transgene expression with that of a housekeeping gene, SLEEK (selection by essential-gene exon knock-in) enable...
Drugging RNA
Drugging RNA
Small molecules that target messenger RNA have therapeutic potential, but the field still lacks an unqualified success. Co...
Pangenome graph construction from genome alignments with Minigraph-Cactus
Pangenome graph construction from genome alignments with Minigraph-Cactus
Pangenome references address biases of reference genomes by storing a representative set of diverse haplotypes and their a...
Comparative analysis of cell–cell communication at single-cell resolution
Comparative analysis of cell–cell communication at single-cell resolution
Inference of cell–cell communication from single-cell RNA sequencing data is a powerful technique to uncover interce...
A prime editor mouse to model a broad spectrum of somatic mutations in vivo
A prime editor mouse to model a broad spectrum of somatic mutations in vivo
Genetically engineered mouse models only capture a small fraction of the genetic lesions that drive human cancer. Current ...
scDesign3 generates realistic in silico data for multimodal single-cell and spatial omics
scDesign3 generates realistic in silico data for multimodal single-cell and spatial omics
We present a statistical simulator, scDesign3, to generate realistic single-cell and spatial omics data, including various...
Author Correction: Deconvolution of clinical variance in CAR-T cell pharmacology and response
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Deep learning models to predict the editing efficiencies and outcomes of diverse base editors
Deep learning models to predict the editing efficiencies and outcomes of diverse base editors
Applications of base editing are frequently restricted by the requirement for a protospacer adjacent motif (PAM), and sele...
How will generative AI disrupt data science in drug discovery?
Brown, T. B. et al. In Adv. Neural Inf. Process. Syst. 33 (eds Larochelle, H. et al.) 1877–1901 (Curran Associates, 2020)....
Fast and accurate protein structure search with Foldseek
Fast and accurate protein structure search with Foldseek
As structure prediction methods are generating millions of publicly available protein structures, searching these database...
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