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Unlocking drug modes of action with multi-dimensional high-throughput metabolic profiling
Unlocking drug modes of action with multi-dimensional high-throughput metabolic profiling
Large-scale profiling of drug-induced metabolic changes have potential for improving drug development but remain challengi...
A human metabolic map of pharmacological perturbations reveals drug modes of action
A human metabolic map of pharmacological perturbations reveals drug modes of action
Understanding a small molecule’s mode of action (MoA) is essential to guide the selection, optimization and clinical...
AAV vectors tested in perfused human livers
AAV vectors tested in perfused human livers
The performance of AAV gene-therapy vectors is studied in machine-perfused human livers — and the presence of fatty ...
A neural network for long-term super-resolution imaging of live cells with reliable confidence quantification
A neural network for long-term super-resolution imaging of live cells with reliable confidence quantification
Super-resolution (SR) neural networks transform low-resolution optical microscopy images into SR images. Application of si...
AAV capsid prioritization in normal and steatotic human livers maintained by machine perfusion
AAV capsid prioritization in normal and steatotic human livers maintained by machine perfusion
Therapeutic efficacy and safety of adeno-associated virus (AAV) liver gene therapy depend on capsid choice. To predict AAV...
A platform for the biomedical application of large language models
A platform for the biomedical application of large language models
Heidelberg University, Faculty of Medicine and Heidelberg University Hospital, Institute for Computational Biomedicine, He...
Quantum-computing-enhanced algorithm unveils potential KRAS inhibitors
Quantum-computing-enhanced algorithm unveils potential KRAS inhibitors
We introduce a quantum–classical generative model for small-molecule design, specifically targeting KRAS inhibitors ...
Uniform volumetric single-cell processing for organ-scale molecular phenotyping
Uniform volumetric single-cell processing for organ-scale molecular phenotyping
Extending single-cell analysis to intact tissues while maintaining organ-scale spatial information poses a major challenge...
Fresh from the biotech pipeline: FDA approvals settle in 2024, but what next?
Fresh from the biotech pipeline: FDA approvals settle in 2024, but what next?
After two volatile years, FDA approvals in 2024 settled closer to their 10-year average. Will nominated commissioner Marty...
Pricey sickle cell gene therapies primed for change
Bluebird Bio and Vertex Pharmaceuticals are the first to participate in a scheme to enable people with sickle cell disease...
Mushroom makes tasty eco-asphalt
Mushroom makes tasty eco-asphalt
Traditionally bitumen, which is made by crude oil distillation, has been used to bind gravel and sand to create our highwa...
Liver-avoiding capsids draw $1.1 billion
Novartis is shoring up its portfolio on gene therapies for inherited neuromuscular diseases by acquiring Kate Therapeutics...
Synthetic GPCRs for controlling cellular responses
Synthetic receptors, such as chimeric antigen receptors, are a powerful tool to modulate cell behavior for therapeutic pur...
Ionis wins FDA nod for triglyceride-lowering rare disease drug
The US Food and Drug Administration has approved Ionis Pharmaceuticals’ drug Tryngolza (olezarsen), as an adjunct to a low...
Therapeutic T cells with synthetic gene circuits act locally
Equipping immune cells with synthetic receptors is an important strategy to expand the repertoire of immunotherapies. Two ...
An organoid model with all three pancreatic lineages resembles fetal pancreas
In many applications of organoid technology, improving model complexity to more closely resemble the native tissue is a ma...
Multiplexed inhibition of immunosuppressive genes with Cas13d for combinatorial cancer immunotherapy
Multiplexed inhibition of immunosuppressive genes with Cas13d for combinatorial cancer immunotherapy
The complex nature of the immunosuppressive tumor microenvironment (TME) requires multi-agent combinations for optimal imm...
Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning
Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning
Efficient and accurate nanocarrier development for targeted drug delivery is hindered by a lack of methods to analyze its ...
Publisher Correction: Engineered platelets as targeted protein degraders and application to breast cancer models
Authors and AffiliationsPharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin–Madison, Madison, WI...
Agriculture to flourish on precision breeding: who will benefit?
Agriculture to flourish on precision breeding: who will benefit?
From corn to bananas, farmers stand to gain from cultivating edited crops that are resilient and sustainable, paired with ...
A cure for HIV? TCR agents seek to wipe out viral reservoirs
A cure for HIV? TCR agents seek to wipe out viral reservoirs
Bispecific T cell receptor molecules designed to wipe out HIV-infected T cells offer glimpses of a cure.
Making space for spatial biology in the clinic
Spatial transcriptomics methods have been slow to move into clinical practice, but spatial proteomics are cheaper and more...
A DNA language model based on multispecies alignment predicts the effects of genome-wide variants
A DNA language model based on multispecies alignment predicts the effects of genome-wide variants
Protein language models have demonstrated remarkable performance in predicting the effects of missense variants but DNA la...
Publisher Correction: The global patent landscape of functional food innovation
Authors and AffiliationsInstitute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, Magdalenka, Pola...
NIS-Seq enables cell-type-agnostic optical perturbation screening
NIS-Seq enables cell-type-agnostic optical perturbation screening
Optical pooled screening offers a broader-scale alternative to enrichment-based perturbation screening, using fluorescence...
Toward a safer and more secure US bioeconomy
To enhance the safety and security of the US bioeconomy, a new public–private partnership should be established to f...
The devolution of biosimilars regulations
After two decades of experience with biosimilars, physicochemical and in vitro biological comparison with their reference ...
CRISPR-StAR enables high-resolution genetic screening in complex in vivo models
CRISPR-StAR enables high-resolution genetic screening in complex in vivo models
Pooled genetic screening with CRISPR–Cas9 has enabled genome-wide, high-resolution mapping of genes to phenotypes, b...
Plant bling: cellulose that sparkles
Plant bling: cellulose that sparkles
Plant-based glitter with sustainable credentials has arrived. Cambridge, UK–...
A synthetic scaffold to target peptide–MHC complexes
A synthetic scaffold to target peptide–MHC complexes
A method for designing high-affinity, specific binders to peptide–MHC complexes may improve the next generation of a...
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