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Epigenetic changes in inflammatory arthritis monocytes contribute to disease and can be targeted by JAK inhibition
Epigenetic changes in inflammatory arthritis monocytes contribute to disease and can be targeted by JAK inhibition
AbstractObjectives. How the local inflammatory environment regulates epigenetic changes in the context of inflammatory art...
Long non-coding RNA expression profiling of subchondral bone reveals AC005165.1 modifying FRZB expression during osteoarthritis
AbstractObjective. To gain insight in the expression profile of long non-coding RNAs in osteoarthritis (OA) subchondral bo...
Efficacy and safety of secukinumab in patients with spondyloarthritis and enthesitis at the Achilles tendon: Results from a Phase 3b trial
AbstractObjective. ACHILLES aimed to demonstrate efficacy of secukinumab on Achilles’ tendon enthesitis in spondyloarthrit...
Neuropsychiatric systemic lupus erythematosus is associated with a distinct type and shape of cerebral white matter hyperintensities
AbstractOBJECTIVES. Advanced white matter hyperintensity (WMH) markers on brain MRI may help reveal underlying mechanisms ...
Plasma Pyruvate Kinase M2 as a marker of vascular inflammation in Giant Cell Arteritis
AbstractObjectives. Giant Cell Arteritis (GCA) is a large vessel vasculitis in which metabolically active immune cells pla...
Telemedicine in rheumatology: A mixed methods study exploring acceptability, preferences and experiences among patients and clinicians
AbstractObjectives. The Covid-19 pandemic necessitated a rapid global transition towards telemedicine; yet much remains un...
Corrigendum to: Diagnostic delay is common for patients with axial spondyloarthritis: results from the National Early Inflammatory Arthritis Audit
Rheumatology 2021;
Development and validation of a prognostic model for leflunomide discontinuation with abnormal blood-tests during long-term treatment: cohort study using data from Clinical Practice Research Datalink Gold and Aurum
AbstractObjective. To develop and validate a prognostic model for leflunomide discontinuation with abnormal blood-test res...
FABP3 overexpression promotes vascular fibrosis in Takayasu’s arteritis via enhancing fatty acid oxidation in aorta adventitial fibroblasts
AbstractObjective. To identify the role of fatty acid-binding protein-3 (FABP3) in vascular fibrosis in Takayasu’s arterit...
Work participation is reduced during the development of RA, months before clinical arthritis manifests
AbstractObjectives. We investigated if work participation is affected in patients with arthralgia during transition to rhe...
Corrigendum to: A systematic review and meta-analysis to inform cancer screening guidelines in idiopathic inflammatory myopathies
Rheumatology 2021;60:2615–2628
Comment on: The sFlt-1 to PlGF Ratio in Pregnant Women with Rheumatoid Arthritis: Impact of Disease Activity and Sulfasalazine Use. Reply
Hieronymus T W Smeele, Rugina I Neuman, Cecile Berenguer, A H Jan Danser, Willy Visser, Radboud J E M Dolhain; Comment on:...
Histopathology, salivary flow and ultrasonography of the parotid gland: three complementary measurements in primary Sjögren’s syndrome
AbstractObjective. The involvement of salivary glands in primary Sjögren’s syndrome (pSS) can be assessed in different way...
Filgotinib decreases both vertebral body and posterolateral spine inflammation in ankylosing spondylitis: results from the TORTUGA trial
AbstractObjectives. Assess the effects of filgotinib on inflammatory and structural changes at various spinal locations, b...
Burden of comorbid conditions in children and young people with juvenile idiopathic arthritis: a collaborative analysis of 3 JIA registries
AbstractObjectives. Burden of comorbidities are largely unknown in JIA. From 2000, national and international patient regi...
Systemic sclerosis sine scleroderma in children
AbstractObjective. Juvenile Systemic Sclerosis (JSSc) is a rare condition in childhood and its variety with no skin involv...
Tumour necrosis factor inhibitor dose adaptation in psoriatic arthritis and axial spondyloarthritis (TAPAS): a retrospective cohort study
AbstractObjectives. We investigated the effect of disease activity-guided dose optimisation (DAGDO) of Tumour Necrosis Fac...
Incidence and prevalence of Juvenile Idiopathic Arthritis in the United Kingdom 2000-2018: results from the Clinical Practice Research Datalink
AbstractObjectives. The incidence and prevalence of Juvenile Idiopathic Arthritis (JIA) was last estimated in the UK in 19...
Synovial single-cell heterogeneity, zonation, and interactions: a patchwork of effectors in arthritis
Abstract. Despite extensive research, there is still no treatment that would lead to remission in all patients with rheuma...
Associations between joint pathologies and central sensitization in persons with hand osteoarthritis: results from the Nor-Hand study
AbstractObjective. Pain sensitization is associated with pain severity in persons with hand osteoarthritis (OA). What cont...
Corrigendum to: Safety of ixekizumab in adult patients with plaque psoriasis, psoriatic arthritis and axial spondyloarthritis: data from 21 clinical trials
Rheumatology 2020;59:3835–3845
Relationship of Anifrolumab Pharmacokinetics With Efficacy and Safety in Patients With Systemic Lupus Erythematosus
AbstractObjectives. To characterize the relationship of anifrolumab pharmacokinetics with efficacy and safety in patients ...
Response to Secukinumab on Synovitis using Power Doppler Ultrasound in Psoriatic Arthritis: 12-week Results from a Phase III Study, ULTIMATE
AbstractObjectives. To investigate the dynamics of response of synovitis to interleukin (IL)-17A inhibition with secukinum...
Vascular imaging of patients with refractory Takayasu arteritis treated with tocilizumab: post hoc analysis of a randomized controlled trial
AbstractObjectives. Tocilizumab, an anti–interleukin-6 receptor antibody, was investigated in patients with refractory Tak...
Sarilumab monotherapy versus sarilumab and methotrexate combination therapy in patients with rheumatoid arthritis
AbstractObjective. Sarilumab, as monotherapy or in combination with conventional synthetic DMARDs, such as methotrexate (M...
Increased incidence of inflammatory bowel disease on etanercept in juvenile idiopathic arthritis regardless of concomitant methotrexate use
AbstractObjectives. To describe risk factors for inflammatory bowel disease (IBD) development in a cohort of children with...
Utility of interval kidney biopsy in ANCA-associated vasculitis
AbstractObjectives. Anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) is a rare autoimmune disorder th...
Serum IFNα2 measured by single-molecule array associates with systemic disease manifestations in Sjögren’s syndrome
AbstractObjectives. Type I IFN (IFN-I) activation is a prominent feature of primary SS (pSS), SLE, and SSc. Ultrasensitive...
Filgotinib or Lanraplenib in Moderate to Severe Cutaneous Lupus Erythematosus: A Phase 2, Randomised, Double-Blind, Placebo-Controlled Study
AbstractObjectives. To explore the safety and efficacy of filgotinib (FIL), a Janus kinase 1 inhibitor, and lanraplenib (L...
Call for emergency action to limit global temperature increases, restore biodiversity and protect healthWealthy nations must do much more, much faster*
The UN General Assembly in September 2021 will bring countries together at a critical time for marshalling collective acti...
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