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Positive Expression of IGFBP2 as a Novel Prognostic Biomarker for Patients with Lower-Grade Gliomas
Background: Previous studies have identified insulin-like growth factor-binding protein 2 (IGFBP2) as a target gene associ...
Aberrant DNA Methylation of FTH-1 and SHXO2 Contributes to Lung Cancer Progression
Background: Lung cancer is the most lethal malignancy in the world due to its poor prognosis. DNA methylation change has b...
Cytogenetics and Molecular Abnormalities in Pediatric Patients with Acute Myeloid Leukemia in a Referral Center in Tehran, Iran
Background: Acute myeloid leukemia (AML) accounts for 15%-20% of childhood leukemia. A variety of cytogenetic abnormalitie...
Endometriosis-associated Ovarian Cancer, from Risk Factors to Survival Rate: A Systematic Review and Meta-Analysis
Background: Endometriosis experts recommend monitoring patients until menopause before considering surgery, with concerns ...
Identification of Breast Cancer Biomarkers by Constructing Protein-Protein Interaction and miRNAs-mRNAs Networks
Background: In cancer-related diseases, early detection and control of disease progression are very important for successf...
Anticancer Activity of Holothuria Leucospilota-Derived Saponin on MNK45 Gastric Cancer Cell via Upregulation of CDH1 Hub Gene
Background: The treatment of gastric cancer (GC) is still quite challenging. Yet, marine invertebrates have been found to ...
Deciphering the Genetic Alterations in PIK3CA Gene Interacting Network and Their Putative Association with Breast Cancer: A Computational Approach
Background: Cancer is a polygenic complex disorder involving a network of genes. The phosphatidylinositol 3-kinase (PIK3CA...
Triple-Negative Breast Cancer: Emerging Biomarkers for Early Diagnosis, Prognosis, and Treatment
Breast cancer (BC) is a heterogeneous disease characterized by significant global mortality and incidence rates. Annually,...
The Implication of Chuang's Prognostic Scale in Metastatic Gastric Cancer
Background: Patients with metastatic gastric cancer (mGC) endure a significant symptom burden following subsequent lines o...
Importance of Nectin2, NUF2, and Nectin4 Gene Expression in the Pathogenesis of Different Subtypes of Breast Cancer
Background: The targeted therapy using breast cancer (BC)-associated biomarkers has significantly minimized the side effec...
Cell-in-Cell Phenomena or Tumor-APCs? A Pathologist's Perspective
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The Impact of Glutamine Mouthwash on Preventing Mucositis Following Administration of High Doses of Methotrexate in Children with Acute Lymphoblastic Leukemia: A Randomized Clinical Trial
Background: Acute lymphoblastic leukemia (ALL) represents the predominant childhood cancer. High-dose methotrexate is inte...
Regorafenib versus Cetuximab plus Irinotecan in Third-line Metastatic Colorectal Cancer in Iran: A Model-based Cost-utility Analysis
Background: Metastatic colorectal cancer (mCRC) constitutes a significant health burden globally, accompanied by elevated ...
Epidemiologic Assessment of Intestinal Metaplasia and H. pylori Infection in Shiraz, Iran: A Predictive Model for Metaplasia Occurrence
Background: Classified as a group 1 carcinogen by the World Health Organization, Helicobacter pylori (H. pylori) is implic...
Pathologic Features of Breast Malignancies Undergoing Surgery and Evaluation of Neo-Adjuvant Therapy Efficiency in Shiraz, Iran: A Cross-Sectional Multidimensional Study
Background: Breast cancer, the most prevalent cancer among women, represented 25.4% of all female cancer cases in 2020. Ne...
Using Artificial Intelligence to Mitigate the Side-Effects of Chemotherapy Drugs in Patients at Risk of Heart Failure
Background: Cancer ranks as the second leading cause of death in the United States. Currently, the mortality rate among ca...
Artificial Intelligence in Malignancy: A Comprehensive Review with Emphasis on Breast and Thyroid Cancers
This comprehensive review examines the expansive role of artificial intelligence (AI) in oncology, with a particular focus...
Oct-4 and Its Role in the Oncogenesis of Colorectal Cancer
Colorectal cancer (CRC) ranks among the world’s most prevalent cancers, annually claiming tens of thousands of lives. Earl...
A Review of Molecular Imaging Applications and Challenges in Robotic Precision Surgery
Background: Molecular imaging is transforming medical diagnostics by providing insights into diseases at the molecular and...
Anesthetic Considerations for Labor and Delivery in Cancer Patients: A Review
Background: The trend of postponing childbirth has led to an increased incidence of cancer diagnoses during pregnancy, inc...
Prognostic Significance of TRPS1, GATA3, and CYP4Z1 Expression in Triple-Negative Breast Cancer Patients: An Immunohistochemical Study
Background: Triple-negative breast cancer (TNBC) is characterized by a poor prognosis. Consequently, the current research ...
Effectiveness of Tom and Jerry Cartoon in Reducing Anxiety in Cancer Patients Undergoing Chemotherapy: A Pilot Study
Background: Anxiety is a significant psychological challenge for patients newly diagnosed with cancer and scheduled for ch...
Diagnostic Delay: Nasal Polyp to Extra-nodal Natural Killer T-cell Lymphoma - A Case Report
Extra-nodal natural killer/T-cell lymphoma-nasal type (ENKTCL-NT) represents a rare clinical entity that often masquerades...
A Mimicry of the Tumor Microenvironment's Impact on SLC4A7 (NBCn1) and Caspase-3 Gene Expression in Breast Cancer, along with in Silico Traits of NBCn1
Background: This study investigates the relative expression of the Na+, HCO3- cotransport gene NBCn1, and caspase-3 within...
Impact of Pretreatment Inflammatory Markers in Locally Advanced Head and Neck Cancer Treated with Concurrent Chemoradiotherapy
Background: Inflammation, when associated with cancer, has been shown to correlate with a worse prognosis. Neutrophil-lymp...
The Clinical Utility of Biochemical Biomarkers in Colorectal Cancer
Colorectal cancer (CRC) ranks as the third most prevalent cancer worldwide and is a leading cause of cancer-related mortal...
Investigating Post-treatment Breast Pain Severity in Breast Cancer Patients and Its Correlation with Serum Vitamin D and hs-CRP Levels
Background: Current data indicate that serum vitamin D and susceptible C-reactive protein (hs-CRP) levels, both indicative...
Can Dietary Iron Bioavailability Influence Colorectal Cancer Risk and Prognosis?
Colorectal cancer (CRC) stands apart from other malignancies due to its pronounced association with dietary patterns. Appr...
GLUT1 Expression in Oral Squamous Cell Carcinoma and Its Significance
Background: GLUT1, a glucose transport protein, exhibits heightened expression in malignant cells, leading to increased gl...
Papillary Tumor of the Pineal Region with Leptomeningeal Seeding: A Case Report and Literature Review
Papillary tumor of the pineal region (PTPR) is an infrequent neoplasm arising from the ependymal cells of the sub-commissu...
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