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Regulation of lipid and serine metabolism by the oncogene c-Myc
Regulation of lipid and serine metabolism by the oncogene c-Myc
Several studies investigate the function and use of MYC, a multifunctional oncogene. Encoded by the Myc gene, this transcr...
Circulating tumor cells in lung cancer: Integrating stemness and heterogeneity to improve clinical utility
Circulating tumor cells in lung cancer: Integrating stemness and heterogeneity to improve clinical utility
Circulating tumor cells (CTC), released by primary tumors into the bloodstream, represent a valuable source to inform on c...
Therapeutic potential of hedgehog signaling in advanced cancer types
Therapeutic potential of hedgehog signaling in advanced cancer types
Available online 8 March 2024Author links open overlay panel, AbstractIn this chapter, we have made an attempt to elucidat...
Importance of targeting various cell signaling pathways in solid cancers
Importance of targeting various cell signaling pathways in solid cancers
The earliest proof of the existence of human cancer is the bone tumors discovered in a fossilized hominid, which dates bac...
An Overview of the Unfolded Protein Response (UPR) and Autophagy Pathways in Human Viral Oncogenesis
An Overview of the Unfolded Protein Response (UPR) and Autophagy Pathways in Human Viral Oncogenesis
Autophagy and Unfolded Protein Response (UPR) can be regarded as the safe keepers of cells exposed to intense stress. Auto...
Targeting KRAS and SHP2 signaling pathways for immunomodulation and improving treatment outcomes in solid tumors
Targeting KRAS and SHP2 signaling pathways for immunomodulation and improving treatment outcomes in solid tumors
Available online 20 February 2024Author links open overlay panel, , AbstractHistorically, KRAS has been considered ‘undrug...
Cellular signaling in glioblastoma: A molecular and clinical perspective
Cellular signaling in glioblastoma: A molecular and clinical perspective
Glioblastoma multiforme (GBM) is the common term for most gliomas given a CNS WHO Grade IV rating (Brennan et al., 2009, G...
Factors affecting heterogeneity in breast cancer microenvironment: A narrative mini review
Factors affecting heterogeneity in breast cancer microenvironment: A narrative mini review
Breast cancer (BC) is the cancer type with the highest incidence and mortality in women according to GLOBOCAN 2020 (Sung e...
Epigenetic regulation of cancer
Epigenetic regulation of cancer
Volume 383, 2024, Pages xi-xvAuthor links open overlay panel, Section snippetsAcknowledgmentsLG is/has been supported (as ...
Chapter One - Epigenetic therapeutic strategies in pancreatic cancer
Chapter One - Epigenetic therapeutic strategies in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) has an incidence of 495,773 cases per year worldwide and accounts for 466,003 deat...
Chapter Three - Epigenetic control of cell signalling in cancer stem cells
Chapter Three - Epigenetic control of cell signalling in cancer stem cells
The cancer cells in a tumour mass are highly heterogeneous, consisting of different populations of cells (Meacham and Morr...
Chapter Four - Epigenetic inhibitors for cancer treatment
Chapter Four - Epigenetic inhibitors for cancer treatment
Cancer remains a leading cause of death worldwide. Ten million deaths were caused by cancer in 2020, accounting for 1/6 of...
Chapter Five - Epigenetics as a determinant of radiation response in cancer
Chapter Five - Epigenetics as a determinant of radiation response in cancer
Radiation therapy is a cornerstone of modern cancer therapy. Alongside surgery, chemotherapy and molecularly-targeted ther...
Chapter Six - Epigenome editing in cancer: Advances and challenges for potential therapeutic options
Chapter Six - Epigenome editing in cancer: Advances and challenges for potential therapeutic options
Chromosomes were first identified as carriers of genetic information in 1902 (Satzinger, 2008) and later characterized as ...
Inflammatory breast cancer: Epidemiologic data and therapeutic results
Inflammatory breast cancer: Epidemiologic data and therapeutic results
The first clinical description of Inflammatory breast cancer (IBC) was reported in 1814 by Sir Charles Bell as a “purple c...
Inflammatory breast cancer biomarkers and biology
Inflammatory breast cancer biomarkers and biology
A challenging characteristic of inflammatory breast cancer (IBC) to physicians is the lack of a collective tumor mass. Ins...
Advances in targets in inflammatory breast cancer
Advances in targets in inflammatory breast cancer
AXL receptor tyrosine kinase (also called tyrosine-protein kinase receptor UFO), a member of the tumor-associated macropha...
The crosstalk between miRNAs and signaling pathways in human cancers: Potential therapeutic implications
The crosstalk between miRNAs and signaling pathways in human cancers: Potential therapeutic implications
Cancer stands as a leading global cause of fatalities. The principal hallmark of cancer is the rapid and uncontrolled divi...
Epigenetic therapeutic strategies in pancreatic cancer
Epigenetic therapeutic strategies in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) has an incidence of 495,773 cases per year worldwide and accounts for 466,003 deat...
Chapter One - Novel technologies for applying immune checkpoint blockers
Chapter One - Novel technologies for applying immune checkpoint blockers
Cancer cells develop several ways to subdue the immune system among others via upregulation of inhibitory immune checkpoin...
Chapter Two - Next-generation deconvolution of transcriptomic data to investigate the tumor microenvironment
Chapter Two - Next-generation deconvolution of transcriptomic data to investigate the tumor microenvironment
Tumor cells are embedded in a multicellular ecosystem, called the tumor microenvironment (TME), which encompasses differen...
Chapter Three - Immune checkpoints targeting dendritic cells for antibody-based modulation in cancer
Chapter Three - Immune checkpoints targeting dendritic cells for antibody-based modulation in cancer
The discovery of dendritic cells (DC) is a key breakthrough in the field of immunology (Steinman & Cohn, 1973). DC pla...
Chapter Six - Immune modulation during anti-cancer radio(immuno)therapy
Chapter Six - Immune modulation during anti-cancer radio(immuno)therapy
Mutations in oncogenes, tumour-suppressor genes and microRNA genes can lead to cancer development. Although in most cases ...