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Combining radiotherapy and NK cell-based therapies: The time has come
Cancer immunotherapy has been of increasing interest over the last two decades, as immune checkpoint inhibitors (ICI) (Dia...
Immunomodulatory effects of targeted radionuclide therapy
Among multiple cell death pathways, cancer cells exposed to conventional external X-rays radiotherapy (X-RT) or targeted r...
The role of dendritic cells in radiation-induced immune responses
Radiation therapy is one of the three pillars of conventional cancer treatment, recently joined by immunotherapy as the fo...
Myeloid-derived suppressor cells: Emerging players in cancer and beyond
Volume 375, 2023, Pages xiii-xixAuthor links open overlay panel, Section snippetsFundingC.J.-C. is supported by a Margarit...
Chapter One - Cancer-cell-intrinsic mechanisms regulate MDSCs through cytokine networks
Cancer immunotherapy has been established as the fifth pillar of cancer therapy. However, many patients, such as prostate ...
Chapter Two - Myeloid-derived suppressor cells in head and neck squamous cell carcinoma
Head and neck squamous cell carcinoma (HNSCC) develop from the mucosal epithelium in the oral cavity, pharynx and larynx. ...
Chapter Three - Knowing the myeloid-derived suppressor cells: Another enemy of sarcomas patients
Maternal fever is common during pregnancy and has for many years been suspected to harm the developing fetus. Whether incr...
Chapter Four - Role of myeloid-derived suppressor cells during Trypanosoma cruzi infection
Trypanosoma cruzi (T. cruzi) is a hemoflagellate protozoan parasite that causes Chagas Disease (CD). Despite the efforts m...
Chapter Five - Emerging avenues linking myeloid-derived suppressor cells to periodontal disease
The periodontium, also known as periodontal tissue, is a complex structure composed of the tissues that surround and suppo...
Chapter Six - Myeloid-derived suppressor cells: A new emerging player in endometriosis
Endometriosis is an estrogen-dependent gynecological benign disorder affecting approximately 190 million women worldwide (...
Mycobacterial infection alters host mitochondrial activity
Mitochondria are the power center of the cell, which are responsible not only for ATP synthesis but the only source for cr...
Chapter One - The bacterial origin of mitochondria: Incorrect phylogenies and the importance of metabolic traits
Contrary to other cellular organelles, mitochondria have several features of bacterial nature (Searcy, 2003), starting wit...
Chapter Two - Legionella and mitochondria, an intriguing relationship
Mitochondria are emblematic structures in cell biology and have traditionally been considered the powerhouse of the cell, ...
Chapter Three - Role of mitochondrial outer membrane permeabilization during bacterial infection
The outer mitochondrial membrane not only regulates import into mitochondria, it also regulates apoptosis. Permeabilizatio...
Chapter Four - The interplay between selective types of (macro)autophagy: Mitophagy and xenophagy
During evolution, cells have developed a plethora of mechanisms to adapt to endogenous deleterious stressors (i.e. DNA dam...
Chapter Five - Role of mitochondria in regulating immune response during bacterial infection
Mitochondria are semi-autonomous organelles and according to the endosymbiotic theory it is of bacterial origin (purple ph...
Are charged particles a good match for combination with immunotherapy? Current knowledge and perspectives
Treatment of cancer nowadays commonly applies combinations of local as well as systemic therapies. Among these, the combin...
Role of myeloid-derived suppressor cells during Trypanosoma cruzi infection
Trypanosoma cruzi (T. cruzi) is a hemoflagellate protozoan parasite that causes Chagas Disease (CD). Despite the efforts m...
Chemotherapy to potentiate the radiation-induced immune response
Recent advances in immuno-oncology have led to spectacular responses to immunotherapy (IO) (Rao et al., 2019). However, th...
Interaction between host cell mitochondria and Coxiella burnetii
Available online 1 February 2023Author links open overlay panel, , AbstractIn order to successfully establish a replicativ...
Bacterial and mammalian F1FO-ATPase: Structural similarities and divergences to exploit in the battle against Mycobacterium tuberculosis
Aerobic synthesis of ATP is the molecular phenomenon in biology sustained by the combustion of nutrients and the consumpti...
Fatty acid metabolism and radiation-induced anti-tumor immunity
The unprecedented bench-to-bedside success of modern immunotherapies has transformed the standard of care for various adva...
The various functions and phenotypes of macrophages are also reflected in their responses to irradiation: A current overview
Available online 30 January 2023Author links open overlay panelAbstractMacrophages are a vital part of the innate immune s...
The bacterial origin of mitochondria: Incorrect phylogenies and the importance of metabolic traits
Contrary to other cellular organelles, mitochondria have several features of bacterial nature (Searcy, 2003), starting wit...
Myeloid-derived suppressor cells in head and neck squamous cell carcinoma
Head and neck squamous cell carcinoma (HNSCC) develop from the mucosal epithelium in the oral cavity, pharynx and larynx. ...
Knowing the myeloid-derived suppressor cells : Another enemy of sarcomas patients
Immune system plays an ambivalent role in cancer because is able to promote both suppression and progression of the tumor....
Emerging avenues linking myeloid-derived suppressor cells to periodontal disease
The periodontium, also known as periodontal tissue, is a complex structure composed of the tissues that surround and suppo...
Myeloid-derived suppressor cells: A new emerging player in endometriosis
Endometriosis is an estrogen-dependent gynecological benign disorder affecting approximately 190 million women worldwide (...
Impact of radiation therapy on healthy tissues
Available online 30 December 2022Author links open overlay panelAbstractRadiation therapy has a fundamental role in the ma...
Radiation-induced immune response in novel radiotherapy approaches FLASH and spatially fractionated radiotherapies
Radiation therapy is currently undergoing a paradigm shift, sparked by the increasing evidence of the importance of the so...
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