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Circulating tumor cells: from biotech innovation to clinical utility
Circulating tumor cells: from biotech innovation to clinical utility
J. Pascual et al.ESMO recommendations on the use of circulating tumour DNA assays for patients with cancer: A report from ...
Chapter One - Latest advances in clinical studies of circulating tumor cells in early and metastatic breast cancer
Chapter One - Latest advances in clinical studies of circulating tumor cells in early and metastatic breast cancer
The myocardial infarct size can be reduced by pharmacological postconditioning using cardioprotective agents. Neuregulin-1...
Chapter Two - Can we define breast cancer HER2 status by liquid biopsy?
Chapter Two - Can we define breast cancer HER2 status by liquid biopsy?
Breast cancer is the most common type of cancer as well as the first cause of cancer-specific mortality among women worldw...
Chapter Three - Models to study CTCs and CTC culture methods
Chapter Three - Models to study CTCs and CTC culture methods
Cancer is a major public health problem and it remains the leading cause of death worldwide. There were an estimated 18.1 ...
Chapter Four - Settling the uncertainty about unconventional circulating tumor cells: Epithelial-to-mesenchymal transition, cell fusion and trogocytosis
Chapter Four - Settling the uncertainty about unconventional circulating tumor cells: Epithelial-to-mesenchymal transition, cell fusion and trogocytosis
Circulating tumor cells (CTCs) were first documented by Thomas Ashworth in 1869 (Ashworth, 1869), when he first documented...
Chapter Five - Circulating tumor cells in cancer-risk populations as a cancer interception tool
Chapter Five - Circulating tumor cells in cancer-risk populations as a cancer interception tool
Circulating tumor cells (CTCs) have known prognostic implications in metastatic castration–resistant prostate cancer, but ...
Chapter Six - Circulating tumor cells and host immunity: A tricky liaison
Chapter Six - Circulating tumor cells and host immunity: A tricky liaison
Cancer can affect all human organs and tissues and ranks as a prominent cause of death as well as an obstruction to increa...
Epigenetics as a determinant of radiation response in cancer
Epigenetics as a determinant of radiation response in cancer
Radiation therapy is a cornerstone of modern cancer therapy. Alongside surgery, chemotherapy and molecularly-targeted ther...
Can we define breast cancer HER2 status by liquid biopsy?
Can we define breast cancer HER2 status by liquid biopsy?
Breast cancer is the most common type of cancer as well as the first cause of cancer-specific mortality among women worldw...
Latest advances in clinical studies of circulating tumor cells in early and metastatic breast cancer
Latest advances in clinical studies of circulating tumor cells in early and metastatic breast cancer
Breast cancer is now the most diagnosed cancer worldwide, accounting for 2.3 million new cases in 2020. It is also the lea...
Chapter One - Epigenetic regulation of epithelial–mesenchymal transition during cancer development
Chapter One - Epigenetic regulation of epithelial–mesenchymal transition during cancer development
Epithelial–mesenchymal transition (EMT) is a reversible biological process that enables epithelial cells to become mesench...
Chapter Two - Novel insights into DNA methylation-based epigenetic regulation of breast tumor angiogenesis
Chapter Two - Novel insights into DNA methylation-based epigenetic regulation of breast tumor angiogenesis
Angiogenesis is a pre-requisite process for tumor growth and progression and is not only involved in shuttling nutrients, ...
Chapter Three - Super-enhancer landscape rewiring in cancer: The epigenetic control at distal sites
Chapter Three - Super-enhancer landscape rewiring in cancer: The epigenetic control at distal sites
Accumulating evidence indicates that CXC chemokine receptor 6 (CXCR6) has a crucial role in cancer development and progres...
Chapter Four - Non-coding RNAs in the epigenetic landscape of cutaneous T-cell lymphoma
Chapter Four - Non-coding RNAs in the epigenetic landscape of cutaneous T-cell lymphoma
Cutaneous T-cell lymphoma is a type of non-Hodgkin lymphoma that belongs to a large group of lymphoproliferative disorders...
Chapter Five - Epigenetic mechanism of therapeutic resistance and potential of epigenetic therapeutics in chemorefractory prostate cancer
Chapter Five - Epigenetic mechanism of therapeutic resistance and potential of epigenetic therapeutics in chemorefractory prostate cancer
Of all the hallmarks, the one used to define any condition as cancer is uncontrolled growth. Cancers that are mechanistica...
Chapter Six - Epigenetic inhibitors and their role in cancer therapy
Chapter Six - Epigenetic inhibitors and their role in cancer therapy
Genetics was long believed to be the critical factor determining cell phenotype. However, detecting different phenotypes s...
Circulating tumor cells in cancer-risk populations as a cancer interception tool
Circulating tumor cells in cancer-risk populations as a cancer interception tool
Available online 19 August 2023Author links open overlay panel, , , , , AbstractCancer interception (CI) is a new approach...
Epigenetic control of cell signalling in cancer stem cells
Epigenetic control of cell signalling in cancer stem cells
The cancer cells in a tumour mass are highly heterogeneous, consisting of different populations of cells (Meacham and Morr...
Circulating tumor cells and host immunity: A tricky liaison
Circulating tumor cells and host immunity: A tricky liaison
During their dissemination, circulating tumor cells (CTCs) steadily face the immune system, which is a key player in the w...
Immune checkpoints targeting dendritic cells for antibody-based modulation in cancer
Immune checkpoints targeting dendritic cells for antibody-based modulation in cancer
The discovery of dendritic cells (DC) is a key breakthrough in the field of immunology (Steinman & Cohn, 1973). DC pla...
Settling the uncertainty about unconventional circulating tumor cells: Epithelial-to-mesenchymal transition, cell fusion and trogocytosis
Settling the uncertainty about unconventional circulating tumor cells: Epithelial-to-mesenchymal transition, cell fusion and trogocytosis
Circulating tumor cells (CTCs) were first documented by Thomas Ashworth in 1869 (Ashworth, 1869), when he first documented...
Models to study CTCs and CTC culture methods
Cancer is a major public health problem and it remains the leading cause of death worldwide. There were an estimated 18.1 ...
Chapter Three - Armored modified vaccinia Ankara in cancer immunotherapy
The concept of utilizing vaccination to activate innate and adaptive immune responses against cancer dates back to the lat...
CHAPTER FOUR - Alphaviruses in cancer immunotherapy
Humans naturally transition from walking to running at a point known as the walk-to-run transition (WRT). The WRT commonly...
CHAPTER FIVE - Oncolytic viruses as treatment for adult and pediatric high-grade gliomas: On the way to clinical success
Nowadays, ionizing radiations have numerous applications, especially in medicine for diagnosis and therapy. Pharmacologica...
CHAPTER SIX - Oncolytic viruses in hematological malignancies: hijacking disease biology and fostering new promises for immune and cell-based therapies
The biological diversity of microbial pathogenic agents renders a wide range of propensity to diseases, depending on the d...
CHAPTER SEVEN - Oncolytic virotherapy in lung cancer
Lung tumors are one of the most aggressive threats affecting humans. Current therapeutic approaches have improved patients...
CHAPTER EIGHT - Rational selection of an ideal oncolytic virus to address current limitations in clinical translation
Food safety is a major global public health issue. The majority of traditional culture-based methods have lengthy detectio...
Epigenetic inhibitors and their role in cancer therapy
Genetics was long believed to be the critical factor determining cell phenotype. However, detecting different phenotypes s...
Immune modulation during anti-cancer radio(immuno)therapy
Mutations in oncogenes, tumour-suppressor genes and microRNA genes can lead to cancer development. Although in most cases ...
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