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Combined Oral Contraceptives As Victims of Drug Interactions [50th Anniversary Celebration Collection-Minireview]
Combined Oral Contraceptives As Victims of Drug Interactions [50th Anniversary Celebration Collection-Minireview]
AbstractCombined oral contraceptives (COCs) are widely used in women of reproductive age in the United States. Metabolism ...
Characterization of Enzymes Involved in Nintedanib Metabolism in Humans [Article]
Characterization of Enzymes Involved in Nintedanib Metabolism in Humans [Article]
AbstractNintedanib, which is used to treat idiopathic pulmonary fibrosis and non–small cell lung cancer, is metabolized to...
Inactivation of Human Aldehyde Oxidase by Small Sulfhydryl-Containing Reducing Agents [Article]
Inactivation of Human Aldehyde Oxidase by Small Sulfhydryl-Containing Reducing Agents [Article]
AbstractHuman aldehyde oxidase (hAOX1) is a molybdoflavoenzyme that belongs to the xanthine oxidase (XO) family. hAOX1 is ...
Mechanistic Investigation of the Time-Dependent Aldehyde Oxidase Inhibitor Hydralazine [Article]
Mechanistic Investigation of the Time-Dependent Aldehyde Oxidase Inhibitor Hydralazine [Article]
AbstractThe anti-hypertensive agent hydralazine is a time-dependent inhibitor of the cytosolic drug-metabolizing enzyme al...
Mechanistic Study of Icaritin-Induced Inactivation of Cytochrome P450 2C9 [Article]
Mechanistic Study of Icaritin-Induced Inactivation of Cytochrome P450 2C9 [Article]
AbstractIcaritin (ICT) is a prenylflavonoid derivative that has been approved by National Medical Products Administration ...
Activation/Inactivation of Anticancer Drugs by CYP3A4: Influencing Factors for Personalized Cancer Therapy [Minireview]
Activation/Inactivation of Anticancer Drugs by CYP3A4: Influencing Factors for Personalized Cancer Therapy [Minireview]
Impact of Physiologic Conditions on CYP3A4-Activated/Deactivated Anticancer DrugsWith respect to nongenetic factors, a ser...
Drug Transporters at the Human Blood-Testis Barrier [Minireview]
Drug Transporters at the Human Blood-Testis Barrier [Minireview]
AbstractTransporters are involved in the movement of many physiologically important molecules across cell membranes and ha...
The Disposition and Metabolism of Bempedoic Acid, a Potent Inhibitor of ATP Citrate Lyase, in Healthy Human Subjects [Articles]
The Disposition and Metabolism of Bempedoic Acid, a Potent Inhibitor of ATP Citrate Lyase, in Healthy Human Subjects [Articles]
AbstractThe disposition and metabolism of bempedoic acid, a selective inhibitor of ATP citrate lyase, were examined in hea...
Identification of PXR Activators from Uncaria Rhynchophylla (Gou Teng) and Uncaria Tomentosa (Cats Claw) [Articles]
Identification of PXR Activators from Uncaria Rhynchophylla (Gou Teng) and Uncaria Tomentosa (Cats Claw) [Articles]
AbstractUncaria rhynchophylla (Gou Teng) and Uncaria tomentosa (cat’s claw) are frequently used herbal supplements in Asia...
Exploring the Pharmacokinetic Mysteries of the Liver: Application of Series Compartment Models of Hepatic Elimination [Articles]
Exploring the Pharmacokinetic Mysteries of the Liver: Application of Series Compartment Models of Hepatic Elimination [Articles]
AbstractAmong the basic hepatic clearance models, the dispersion model (DM) is the most physiologically sound compared wit...
Novel Cytochrome P450 2C94 Functionally Metabolizes Diclofenac and Omeprazole in Dogs [Articles]
Novel Cytochrome P450 2C94 Functionally Metabolizes Diclofenac and Omeprazole in Dogs [Articles]
AbstractCytochromes P450 (P450s or CYPs) are important drug-metabolizing enzymes. Because dogs are frequently used in drug...
Unusual Biotransformation Reactions of Drugs and Drug Candidates [50th Anniversary Celebration Collection-Minireview]
Unusual Biotransformation Reactions of Drugs and Drug Candidates [50th Anniversary Celebration Collection-Minireview]
AbstractDetailed assessment of the fate of drugs in nonclinical test species and humans is essential to ensure the safety ...
Relevance of Human Aldoketoreductases and Microbial {beta}-Glucuronidases in Testosterone Disposition [Articles]
Relevance of Human Aldoketoreductases and Microbial {beta}-Glucuronidases in Testosterone Disposition [Articles]
AbstractTestosterone exhibits high variability in pharmacokinetics and glucuronidation after oral administration. Although...
Biotransformation of the Novel Myeloperoxidase Inhibitor AZD4831 in Preclinical Species and Humans [Articles]
Biotransformation of the Novel Myeloperoxidase Inhibitor AZD4831 in Preclinical Species and Humans [Articles]
AbstractWe report herein an in-depth analysis of the metabolism of the novel myeloperoxidase inhibitor AZD4831 ((R)-1-(2-(...
CYP3A4 and CYP3A5 Expression is Regulated by CYP3A4*1G in CRISPR/Cas9-Edited HepG2 Cells [Articles]
CYP3A4 and CYP3A5 Expression is Regulated by CYP3A4*1G in CRISPR/Cas9-Edited HepG2 Cells [Articles]
AbstractFunctional CYP3A4*1G (G>A, rs2242480) in cytochrome P450 3A4 (CYP3A4) regulates the drug-metabolizing enzyme CY...