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Age-Dependent Changes in Cytochrome P450 Abundance and Composition in Human Liver [Articles]
Age-Dependent Changes in Cytochrome P450 Abundance and Composition in Human Liver [Articles]
AbstractCytochrome P450 (CYP) superfamily represents the major drug-metabolizing enzymes responsible for metabolizing over...
Utility of Common In Vitro Systems for Predicting Circulating Metabolites [Articles]
Utility of Common In Vitro Systems for Predicting Circulating Metabolites [Articles]
AbstractIn vitro systems such as cultured hepatocytes are used early in drug development as a proxy for in vivo data to pr...
Differential Selectivity of Human and Mouse ABCC4/Abcc4 for Arsenic Metabolites [Articles]
Differential Selectivity of Human and Mouse ABCC4/Abcc4 for Arsenic Metabolites [Articles]
AbstractMillions of people globally are exposed to the proven human carcinogen arsenic at unacceptable levels in drinking ...
Correlations of Long Noncoding RNA HNF4A-AS1 Alternative Transcripts with Liver Diseases and Drug Metabolism [Articles]
Correlations of Long Noncoding RNA HNF4A-AS1 Alternative Transcripts with Liver Diseases and Drug Metabolism [Articles]
AbstractHepatocyte nuclear factor 4 alpha antisense 1 (HNF4A-AS1) is a long noncoding RNA (lncRNA) gene physically located...
Ontogeny of Hepatic Organic Cation Transporter-1 in Rat and Human [Articles]
Ontogeny of Hepatic Organic Cation Transporter-1 in Rat and Human [Articles]
AbstractThe organic cation transporter (OCT)-1 mediates hepatic uptake of cationic endogenous compounds and xenobiotics. T...
Quantitative Proteomics for Translational Pharmacology and Precision Medicine: State of The Art and Future Outlook [Minireview]
Quantitative Proteomics for Translational Pharmacology and Precision Medicine: State of The Art and Future Outlook [Minireview]
AbstractOver the past 20 years, quantitative proteomics has contributed a wealth of protein expression data, which are cur...
Effects of Compound Probiotics on Pharmacokinetics of Cytochrome 450 Probe Drugs in Rats [Articles]
Effects of Compound Probiotics on Pharmacokinetics of Cytochrome 450 Probe Drugs in Rats [Articles]
Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China (Y.Z., Y.X., T.W., H.Y., ...