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Covalent Binding of Reactive Anhydride of Cantharidin to Biological Amines [Articles]
Covalent Binding of Reactive Anhydride of Cantharidin to Biological Amines [Articles]
AbstractCantharidin is a terpenoid from coleoptera beetles. Cantharidin has been used to treat molluscum contagiosum and s...
Drug Disposition in Neonatal Göttingen Minipigs: Exploring Effects of Perinatal Asphyxia and Therapeutic Hypothermia [Articles]
Drug Disposition in Neonatal Göttingen Minipigs: Exploring Effects of Perinatal Asphyxia and Therapeutic Hypothermia [Articles]
AbstractAsphyxiated neonates often undergo therapeutic hypothermia (TH) to reduce morbidity and mortality. Since both peri...
Mass Balance, Metabolic Pathways, Absolute Bioavailability, and Pharmacokinetics of Giredestrant in Healthy Subjects [Articles]
Mass Balance, Metabolic Pathways, Absolute Bioavailability, and Pharmacokinetics of Giredestrant in Healthy Subjects [Articles]
AbstractGiredestrant is a potent and selective small-molecule estrogen receptor degrader. The objectives of this study wer...
Arsenite-Induced Drug-Drug Interactions in Rats [Articles]
Arsenite-Induced Drug-Drug Interactions in Rats [Articles]
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Key Laboratory of Pharmaceutics...
KLF15-Cyp3a11 Axis Regulates Rifampicin-Induced Liver Injury [Articles]
KLF15-Cyp3a11 Axis Regulates Rifampicin-Induced Liver Injury [Articles]
AbstractRifampicin (RFP) has demonstrated potent antibacterial effects in the treatment of pulmonary tuberculosis. However...
Xenografted Tumors Share Comparable Fraction Unbound and Can Be Surrogated by Mouse Lung Tissue [Articles]
Xenografted Tumors Share Comparable Fraction Unbound and Can Be Surrogated by Mouse Lung Tissue [Articles]
AbstractFree (unbound) drug concentration at the site of action is the key determinant of biologic activity since only unb...