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Activity and Expression of Carboxylesterases and Arylacetamide Deacetylase in Human Ocular Tissues [Articles]
Activity and Expression of Carboxylesterases and Arylacetamide Deacetylase in Human Ocular Tissues [Articles]
AbstractAs a multitissue organ, the eye possesses unique anatomy and physiology, including differential expression of drug...
Chronic Treatment With WY-14643 Induces Tumorigenesis and Triglyceride Accumulation in Mouse Livers [Articles]
Chronic Treatment With WY-14643 Induces Tumorigenesis and Triglyceride Accumulation in Mouse Livers [Articles]
AbstractPeroxisome proliferator-activated receptor α (PPARα) is closely related to lipid metabolism and various liver dise...
Molecular and Functional Characterization of N-Acetyltransferases in Common Marmosets and Pigs [Articles]
Molecular and Functional Characterization of N-Acetyltransferases in Common Marmosets and Pigs [Articles]
AbstractArylamine N-acetyltransferases (NATs) are drug-metabolizing enzymes that are essential for the metabolism of endog...
Cytochrome P450 2J Genes Are Expressed in Dogs, Cats, and Pigs, and Encode Functional Drug-Metabolizing Enzymes [Articles]
Cytochrome P450 2J Genes Are Expressed in Dogs, Cats, and Pigs, and Encode Functional Drug-Metabolizing Enzymes [Articles]
Cytochrome P450s (P450s) have been identified and analyzed in dogs and pigs, species that are often used in preclinical dr...
Isolation and Identification of 3,4-Seco-Solanidine-3,4-dioic Acid as a Urinary Biomarker of CYP2D6 Activity [Articles]
Isolation and Identification of 3,4-Seco-Solanidine-3,4-dioic Acid as a Urinary Biomarker of CYP2D6 Activity [Articles]
AbstractCytochrome P450 2D6 (CYP2D6) is responsible for the metabolism and elimination of approximately 25% of clinically ...
Inhibition of Cytochrome P450 2J2-Mediated Metabolism of Rivaroxaban and Arachidonic Acid by Ibrutinib and Osimertinib [Articles]
Inhibition of Cytochrome P450 2J2-Mediated Metabolism of Rivaroxaban and Arachidonic Acid by Ibrutinib and Osimertinib [Articles]
AbstractCovalent tyrosine kinase inhibitors (TKIs) ibrutinib and osimertinib are associated with cardiac arrhythmia. The i...
Mesenchymal Stem Cell Fates in Murine Acute Liver Injury and Chronic Liver Fibrosis Induced by Carbon Tetrachloride [Articles]
Mesenchymal Stem Cell Fates in Murine Acute Liver Injury and Chronic Liver Fibrosis Induced by Carbon Tetrachloride [Articles]
AbstractMesenchymal stem cells (MSCs) therapy has shown potential benefits in multiple diseases. However, their clinic per...
An Improved Method for Cytochrome P450 Reaction Phenotyping Using a Sequential Qualitative-Then-Quantitative Approach [Article]
An Improved Method for Cytochrome P450 Reaction Phenotyping Using a Sequential Qualitative-Then-Quantitative Approach [Article]
AbstractCytochrome P450 reaction phenotyping to determine the fraction of metabolism (fm) values for individual enzymes is...