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Running rings around a cyclophane
Running rings around a cyclophane
When two phenyl rings are perfectly stacked in a cyclophane structure that is bridged by three helicene linkers, they lose...
Unveiling the final nitrogenase
Unveiling the final nitrogenase
Nitrogenases are enzymes capable of reducing atmospheric nitrogen to ammonia. By better understanding their structure and ...
A glass of half and half
A glass of half and half
A highly stable glass has been prepared by the physical vapour deposition of two materials in equal amounts.
Loop dynamics and the evolution of enzyme activity
Loop dynamics and the evolution of enzyme activity
In the early 2000s, Tawfik presented his ‘New View’ on enzyme evolution, highlighting the role of conformation...
Metal-catalysed C–C bond formation at cyclopropanes
Metal-catalysed C–C bond formation at cyclopropanes
Cyclopropanes are important substructures in natural products and pharmaceuticals. Although traditional methods for their ...
The future of chemistry is language
The future of chemistry is language
Large language models such as GPT-4 have been approaching human-level ability across many expert domains. GPT-4 can accomp...
How to attract the next generation of chemists
How to attract the next generation of chemists
Getting the next generation to participate in chemistry will require dismantling normative approaches to education and men...
Chemical tailoring and stitching
Chemical tailoring and stitching
The synthesis of MXenes is generally constrained by poorly understood and largely uncontrollable chemical reactions. Now, ...
Ensemble determination by NMR data deconvolution
Ensemble determination by NMR data deconvolution
Nuclear magnetic resonance (NMR) is the spectroscopic technique of choice for determining molecular conformations...
Synthesis and applications of mirror-image proteins
Synthesis and applications of mirror-image proteins
The homochirality of biomolecules in nature, such as DNA, RNA, peptides and proteins, has played a critical role in establ...
Direct air capture: fledgling technology or world saviour?
A review of Paul McKendrick’s book Scrubbing the Sky: Inside the Race to Cool the Planet, which looks at the chemist...
Modular methodology
Modular methodology
A bacterial tridecasaccharide known to prevent inflammatory bowel disease has been synthesized.
Hide-and-seek on a universal scale
Hide-and-seek on a universal scale
Hydroxylamine is a molecule of prebiotic interest, but its estimated abundance in space is orders of magnitude greater tha...
Another Lindlar catalyst? I don’t zinc so
Another Lindlar catalyst? I don’t zinc so
Hydrogenation reactions of alkynes to cis-alkenes is typically carried out with precious metal catalysts. A new zinc compl...
Stabilization of photoactive phases for perovskite photovoltaics
Stabilization of photoactive phases for perovskite photovoltaics
Interest in photovoltaics (PVs) based on Earth-abundant halide perovskites has increased markedly in recent years...
Silk chemistry and biomedical material designs
Silk chemistry and biomedical material designs
Silk fibroin has applications in different medical fields such as tissue engineering, regenerative medicine, drug delivery...
Investigating the function and design of molecular materials through terahertz vibrational spectroscopy
Investigating the function and design of molecular materials through terahertz vibrational spectroscopy
Terahertz spectroscopy has proved to be an essential tool for the study of condensed phase materials. Terahertz spectrosco...
Miniaturizing chemistry and biology using droplets in open systems
Miniaturizing chemistry and biology using droplets in open systems
Open droplet microfluidic systems manipulate droplets on the picolitre-to-microlitre scale in an open environment. They co...
Targeting the human gut microbiome with small-molecule inhibitors
Targeting the human gut microbiome with small-molecule inhibitors
The human gut microbiome is a complex microbial community that is strongly linked to both host health and disease. However...
Prospects and challenges for nitrogen-atom transfer catalysis
Prospects and challenges for nitrogen-atom transfer catalysis
Conversion of C–H bonds to C–N bonds via C–H amination promises to streamline the synthesis of nitrogen-...
Design principles of the use of alkynes in radical cascades
Design principles of the use of alkynes in radical cascades
One of the simplest organic functional groups, the alkyne, offers a broad canvas for the design of cascade transformations...
Inclusive teaching at your fingertips
Inclusive teaching at your fingertips
Creating a more inclusive classroom environment starts with educating instructors about the needs of their students. Once ...
Asymmetric reactions involving aryne intermediates
Asymmetric reactions involving aryne intermediates
Although arynes are usually considered fleeting intermediates, they are highly valuable synthons because they enable the i...
Look what the catenane dragged in
Look what the catenane dragged in
Abundant metal copper with a catenane ligand system can effectively induce the oxygen reduction reaction, a promising alte...
Nucleating nanoparticles
Nucleating nanoparticles
A gold nanoparticle colloidal system is used to explore the effect of nanoparticle–substrate interactions on heterog...
Disordered bronze tops the podium
Disordered bronze tops the podium
A thermoelectric material is presented which adopts a tungsten bronze structure with high-entropy properties but ...
Detection and analysis of chiral molecules as disease biomarkers
Detection and analysis of chiral molecules as disease biomarkers
The chirality of small metabolic molecules is important in controlling physiological processes and indicating the health s...
The implication of Mycobacterium tuberculosis-mediated metabolism of targeted xenobiotics
The implication of Mycobacterium tuberculosis-mediated metabolism of targeted xenobiotics
Drug metabolism is generally associated with liver enzymes. However, in the case of Mycobacterium tuberculosis (Mtb), the ...
Aiming beyond slight increases in accuracy
Aiming beyond slight increases in accuracy
Owing to the diminishing returns of deep learning and the focus on model accuracy, machine learning for chemistry might be...
Informatics colourizes polymers
Informatics colourizes polymers
Informatics approaches play an increasingly important role in accelerating the advances of modern materials science. A rec...