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Advancing mechanochemical synthesis by combining milling with different energy sources
Advancing mechanochemical synthesis by combining milling with different energy sources
Owing to its efficiency and unique reactivity, mechanochemical processing of bulk solids has developed into a powerful too...
Pushing the limits
Pushing the limits
In 1997, Kneipp et al. and Nie and Emory independently reported the first examples of single-molecule detection using surf...
Wearable chemical sensors for biomarker discovery in the omics era
Wearable chemical sensors for biomarker discovery in the omics era
Biomarkers are crucial biological indicators in medical diagnostics and therapy. However, the process of biomarker discove...
Scintillating observations
Scintillating observations
An organic scintillator with high imaging resolution and a low detection limit is fabricated by using heavy atoms to incre...
Publisher Correction: Extending machine learning beyond interatomic potentials for predicting molecular properties
Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM, USANikita Fedik, Maksim Kulichenko, Justin S. Smith,...
Light-empowered contra-thermodynamic stereochemical editing
Light-empowered contra-thermodynamic stereochemical editing
Creating, conserving and modifying the stereochemistry of organic compounds has been the subject of significant research e...
Non-specificity as the sticky problem in therapeutic antibody development
Non-specificity as the sticky problem in therapeutic antibody development
Antibodies are highly potent therapeutic scaffolds with more than a hundred different products approved on the ma...
Imine and imine-derived linkages in two-dimensional covalent organic frameworks
Imine and imine-derived linkages in two-dimensional covalent organic frameworks
Covalent organic frameworks (COFs) are porous crystalline polymers that result from the formation of covalent bonds betwee...
Making and breaking cages
Making and breaking cages
Light can be used to trigger the simultaneous, reversible deconstruction and reassembly from one cage complex to another.
Hybrid bilayer membranes as platforms for biomimicry and catalysis
Hybrid bilayer membranes as platforms for biomimicry and catalysis
Hybrid bilayer membrane (HBM) platforms represent an emerging nanoscale bio-inspired interface that has broad implications...
Optimizing the semiconductor–metal-single-atom interaction for photocatalytic reactivity
Optimizing the semiconductor–metal-single-atom interaction for photocatalytic reactivity
Metal single-atom (MSA) catalysts with 100% metal atom utilization and unique electronic properties are attractive cocatal...
Computational design of magnetic molecules and their environment using quantum chemistry, machine learning and multiscale simulations
Computational design of magnetic molecules and their environment using quantum chemistry, machine learning and multiscale simulations
Having served as a playground for fundamental studies on the physics of d and f electrons for almost a century, magnetic m...
Energy- and atom-efficient chemical synthesis with endergonic photocatalysis
Energy- and atom-efficient chemical synthesis with endergonic photocatalysis
Endergonic photocatalysis is the use of light to perform catalytic reactions that are thermodynamically unfavourable. Whil...
Cleaning up with catalysts
Cleaning up with catalysts
A diatomic catalyst comprising PdCu in 2D phosphorene rapidly removes nitrates from water by converting them into nitrogen.
Targeting TAMs
Targeting TAMs
Enzyme-activatable chemokine probes have been shown to selectively target tumour-associated macrophages for the first time.
Mentoring is more important than ever
Mentoring is more important than ever
#MentorFirst ( mentorfirst.org ) is an initiative aimed at dispelling negative practices all-too-often still seen in acade...
Planning a family
Planning a family
To write this article, we spoke to members of the supramolecular chemistry community, including the International Women in...
Demystifying racemic natural products in the homochiral world
Demystifying racemic natural products in the homochiral world
Natural products possess structural complexity, diversity and chirality with attractive functions and biological activitie...
Recent advances in visible light-induced C(sp3)–N bond formation
Recent advances in visible light-induced C(sp3)–N bond formation
Synthetic chemists have long focused on selective C(sp3)–N bond-forming approaches in response to the high value of ...
Hit, miss or maybe
Each month we select articles to showcase in our Research Highlights. Here, we share how we choose which articles to feature.
Decoupled aqueous batteries using pH-decoupling electrolytes
Decoupled aqueous batteries using pH-decoupling electrolytes
Aqueous batteries have been considered as the most promising alternatives to the dominant lithium-based battery technologi...
Taking fluorine to the bridge
Taking fluorine to the bridge
New synthetic methodology enables the formation of a fluorine-substituted benzene bioisostere: strained, saturated bicyclo...
Get in line
Get in line
Centrifugal force can be used to improve the alignment of block copolymer domains in a thin film.
Control of light, spin and charge with chiral metal halide semiconductors
Control of light, spin and charge with chiral metal halide semiconductors
The relationship between the structural asymmetry and optoelectronic properties of functional materials is an active area ...
Weighing up solvent effects
Weighing up solvent effects
The use of molecular balances allows for dissecting competing solvent effects from hydrogen bonding interactions.
Carboranes in drug discovery, chemical biology and molecular imaging
Carboranes in drug discovery, chemical biology and molecular imaging
There exists a paucity of structural innovation and limited molecular diversity associated with molecular frameworks in dr...
Emerging chemistries and molecular designs for flow batteries
Emerging chemistries and molecular designs for flow batteries
Redox flow batteries are a critical technology for large-scale energy storage, offering the promising characteristics of h...
Less breadth more depth
Less breadth more depth
Chemistry degrees are often very broad. What might a degree look like if we covered fewer topics more deeply?
The chemistry of snake venom and its medicinal potential
The chemistry of snake venom and its medicinal potential
The fascination and fear of snakes dates back to time immemorial, with the first scientific treatise on snakebite envenomi...
Solid state synthesis sustains
Solid state synthesis sustains
Solid-state synthesis provides a route to more sustainable fertilizer.