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Deep learning techniques and mathematical modeling allow 3D analysis of mitotic spindle dynamics
Spatial and temporal discontinuities in time-lapse movies frequently disrupt automation methods such as 3D object segmenta...
TLN1 contains a cancer-associated cassette exon that alters talin-1 mechanosensitivity
Gallego-Paez et al. identify a previously unannotated cassette exon in the TLN1 gene that alters the mechanical properties...
PP6 regulation of Aurora A–TPX2 limits NDC80 phosphorylation and mitotic spindle size
Chromosome alignment and segregation in mitosis are tightly regulated. This study shows that PP6 limits the activity of Au...
The exocyst complex is an essential component of the mammalian constitutive secretory pathway
Using kinetic trafficking assays, genetics, and secretomics, Pereira, Stalder et al. demonstrate the role of the exocyst c...
The meiotic LINC complex component KASH5 is an activating adaptor for cytoplasmic dynein
Dynein-driven chromosome movement facilitates chromosome synapsis in prophase I of meiosis, which is essential for genetic...
Productive HIV-1 infection of tissue macrophages by fusion with infected CD4 + T cells
Mascarau et al. demonstrate the relevance of HIV-1 infection of tissue-resident macrophages by fusion with infected CD4+ T...
ATG8-dependent LMX1B-autophagy crosstalk shapes human midbrain dopaminergic neuronal resilience
Jiménez-Moreno et al. demonstrate that human ATG8 proteins stimulate transcriptional cell stress protection via binding to...
Double-checking chromosome segregation
Maiato and Silva discuss the origin and fate of chromosome segregation errors that satisfy the spindle assembly checkpoint...
LC3B is a cofactor for LMX1B-mediated transcription of autophagy genes in dopaminergic neurons
Kournoutis and Johansen preview work from Jiménez-Moreno and colleagues, which shows that LMX1B binds to the Atg8 family m...
Virus update for the M2 “mac-in-touch”
Naghavi previews work from Mascarau et al. identifying that heterotypic cell fusion mediates the transfer of HIV-1 from in...
Correction: Yorkie controls tube length and apical barrier integrity during airway development
Vol. 218, No. 8 | 10.1083/jcb.201809121 | July 17, 2019
Disagreement among the three musketeers of the unfolded protein response
Jipa and Juhász preview results from the lab of Tao Wang which show a surprising antagonism between two branches of the un...
GPI anchors: Regulated as needed
Aguilera-Romero and Muñiz preview work from the Kinoshita lab, which reveals that certain GPI anchor signal sequences and ...
Dynamin2 functions as an accessory protein to reduce the rate of caveola internalization
Larsson et al. demonstrate that the large GTPase dynamin 2 does not mediate fission of caveolae from the plasma membrane a...
CSPP1 stabilizes growing microtubule ends and damaged lattices from the luminal side
Van den Berg et al. provide insight into the biochemical mechanisms of the assembly and maintenance of stable microtubule ...
Quality control ensures fidelity in ribosome assembly and cellular health
Melissa Parker and Katrin Karbstein review our current understanding of the quality control mechanisms governing ribosome ...
LGI3/2–ADAM23 interactions cluster Kv1 channels in myelinated axons to regulate refractory period
Kozar-Gillan and colleagues reveal a novel molecular pathway in node of Ranvier formation by demonstrating that LGI3/2–ADA...
Antagonism between Prdm16 and Smad4 specifies the trajectory and progression of pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease whose molecular etiology remains mostly enigmatic. By discover...
The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA
Jaffray et al. demonstrate that the arsenic-induced, SUMO and ubiquitin-mediated degradation of the PML protein and its on...
The small GTPase ARF3 controls invasion modality and metastasis by regulating N-cadherin levels
Sandilands et al. show that ARF3 acts as a rheostat for the modality of invasion via association with, and control of, N-c...
ARF3 weights the balance for prostate cancer metastasis
Patrick T. Caswell discusses work from Bryant and colleagues which shows how ARF3 impacts metastasis in prostate cancer by...
Open Thy Lattice Osteoclast, Resorb me!
Bakiri previews work from the Weiss lab identifying a new, unexpected role for MMP9/14 in supporting osteoclast function t...
Cappin’ or formin’: Formin and capping protein competition for filament ends shapes actin networks
Vladimir Sirotkin previews work from Wirshing and colleagues, which examines how competition between formins and capping p...
Fine-tune TMEM11 to unleash basal mitophagy
Thomas McWilliams discusses work by Gok et al. which reveals that TMEM11 localizes to the outer mitochondrial membrane whe...
Yogesh Kulathu: Decoding complex intracellular messages
Yogesh Kulathu studies signaling mechanisms with a focus on ubiquitin and other post-translational modifications such as U...
XMAP215 promotes microtubule catastrophe by disrupting the growing microtubule end
Fast-growing microtubules are associated with large protective GTP-caps, raising the question of how cells achieve simulta...
Retinyl esters form lipid droplets independently of triacylglycerol and seipin
Molenaar et al. show that seipin does not play a role in the biogenesis of lipid droplets composed mostly or only of the n...
Anisotropic expansion of hepatocyte lumina enforced by apical bulkheads
Belicova et al. report previously unrecognized apical membrane extensions, forming a pattern reminiscent of the bulkheads ...
William R. Brinkley: A giant in biomedical research and public policy
Susan A. Gerbi, Robert E. Palazzo, William C. Earnshaw, and William T. Schrader discuss the life and achievements of Willi...
Loss of centromeric RNA activates the spindle assembly checkpoint in mammalian female meiosis I
Wu et al. find that in mouse oocytes, minor satellite transcripts play a protective role in preventing pericentromeric het...
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