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XMAP215 promotes microtubule catastrophe by disrupting the growing microtubule end
Fast-growing microtubules are associated with large protective GTP-caps, raising the question of how cells achieve simulta...
Retinyl esters form lipid droplets independently of triacylglycerol and seipin
Molenaar et al. show that seipin does not play a role in the biogenesis of lipid droplets composed mostly or only of the n...
Anisotropic expansion of hepatocyte lumina enforced by apical bulkheads
Belicova et al. report previously unrecognized apical membrane extensions, forming a pattern reminiscent of the bulkheads ...
William R. Brinkley: A giant in biomedical research and public policy
Susan A. Gerbi, Robert E. Palazzo, William C. Earnshaw, and William T. Schrader discuss the life and achievements of Willi...
Loss of centromeric RNA activates the spindle assembly checkpoint in mammalian female meiosis I
Wu et al. find that in mouse oocytes, minor satellite transcripts play a protective role in preventing pericentromeric het...
Ultrastructural plasma membrane asymmetries in tension and curvature promote yeast cell fusion
Muriel et al. present a large correlative light and electron microscopy dataset of 3D tomograms of the fission yeast cell–...
Membrane-bound SCF and VCAM-1 synergistically regulate the morphology of hematopoietic stem cells
Hematopoietic stem cells form a polarized morphology with enhanced adhesion and improved nuclear FOXO3a on membrane-bound ...
Pex30-like proteins function as adaptors at distinct ER membrane contact sites
Membrane contact sites (MCSs) between the ER and other organelles, such as lipid droplets and peroxisomes, are essential f...
RanGTP and the actin cytoskeleton keep paternal and maternal chromosomes apart during fertilization
Mori et al. report that zygotes have active mechanisms that regulate the localization of paternal chromosomes during ferti...
Intracellular wetting mediates contacts between liquid compartments and membrane-bound organelles
Knorr and colleagues discuss the interaction mechanism of phase-separated and membrane-bound compartments and propose that...
Translational regulation in the brain by TDP-43 phase separation
In this study, Gao et al. demonstrate that the global loss of TDP-43 liquid–liquid phase separation perturbs brain functio...
Depolarization induces nociceptor sensitization by Ca V 1.2-mediated PKA-II activation
Isensee et al. describe a peripheral mechanism by which excitation of nociceptive sensory neurons leads to pain hypersensi...
The cell biology of fertilization: Gamete attachment and fusion
Siu et al. review the cell biology of fertilization with a focus on the factors involved in gamete attachment and fusion.
GOLPH3 and GOLPH3L are broad-spectrum COPI adaptors for sorting into intra-Golgi transport vesicles
COPI vesicles recycle Golgi resident proteins within the Golgi stack. Welch et al. combine two orthogonal proteomic analys...
GOLPH3 keeps the Golgi residents at home
Lowe discusses recent work from Welch et al. describing a central role for GOLPH3 in sorting Golgi proteins to maintain Go...
Preventing aneuploidy: The groom must wait until the bride is ready
Verlhac previews work from Mori et al. that describes mechanisms by which the paternal chromosomes are segregated until th...
A polarized anchor for hematopoietic stem cells: Synapse between stem cells and their niche?
Lee and Ding highlight work from Hao et al. describing that membrane-bound stem cell factor synergizes with VCAM-1 to indu...
Rab35 controls formation of luminal projections required for bile canalicular morphogenesis
Cozmescu and Gissen highlight work from Belicova et al., which shows that the hepatocyte apical membrane produces Rab35-de...
Ye Tian: Surveilling stress to live longer
Ye Tian investigates how mitochondrial stress signaling pathways regulate longevity using C. elegans as a model system.
Catalytically inactive, purified RNase H1: A specific and sensitive probe for RNA–DNA hybrid imaging
Crossley et al. demonstrate that GFP-tagged, catalytically inactive RNase H1 protein is a versatile tool for imaging cellu...
A ciliopathy complex builds distal appendages to initiate ciliogenesis
Kumar et al. identify a multiprotein complex called DISCO (distal centriole complex) required to nucleate distal appendage...
Long-lived mitochondrial cristae proteins in mouse heart and brain
Bomba-Warczak et al. use stable isotope labeling of mice and tandem mass spectrometry to discover a pool of mitochondrial ...
Talin rod domain–containing protein 1 (TLNRD1) is a novel actin-bundling protein which promotes filopodia formation
Cowell et al. show that talin rod domain–containing protein 1 (TLNRD1), a protein with homology to the central region of t...
Angulin-1 seals tricellular contacts independently of tricellulin and claudins
Obliteration of the paracellular space at tricellular contacts is crucial for the full barrier function of epithelia. This...
Aurora A kinase activation: Different means to different ends
Tavernier et al. review the different activation mechanisms of the Aurora A kinase during mitotic entry and progression.
The glycoprotein GP130 governs the surface presentation of the G protein–coupled receptor APLNR
Trillet et al. report that the glycoprotein GP130 orchestrates the availability of the G protein–coupled receptor for apel...
Assembly of γ-secretase occurs through stable dimers after exit from the endoplasmic reticulum
The assembly of the γ-secretase complex is coordinated by prior formation in the ER of dimeric subcomplexes, which next in...
Extracellular vesicles from neurons promote neural induction of stem cells through cyclin D1
Extracellular vesicles (EVs) may mediate intercellular communication through the transfer of cargo molecules. Song et al. ...
Mitochondrial regulation of ferroptosis
Gan outlines mitochondrial functions in driving ferroptosis and discusses mitochondria-localized defense systems that quen...
TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination
Ho et al. provide a novel insight on how loss of TDP-43 (a major disease protein) leads to SREBF2 (a key regulator)–depend...