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Bill Weis (1959–2023): Pioneering structural biologist and biochemist who revolutionized our understanding of cell adhesion and Wnt signaling
In October 2023, cell biology lost one of its brightest stars, Bill Weis, gone too soon at the age of 64. Bill was a maste...
The intercentriolar fibers function as docking sites of centriolar satellites for cilia assembly
Ryu et al. investigate a delivery mechanism of centriolar satellites in cilia formation. They propose that intercentriolar...
Moonwalking molecular machines: Unraveling the choreography of myosin filament assembly
Gurley and Peifer highlight work from Quintanilla et al. that reveals how the local biophysical environment regulates asse...
Two ancient membrane pores mediate mitochondrial-nucleus membrane contact sites
By studying a single-cell parasite, this work reveals a new contact between the energy and metabolism hub of the cell, the...
Building the centrosome: PLK-1 controls multimerization of SPD-5
Paul Conduit previews work from Rios et al. that reveals how phosphorylation by PLK-1 induces multimerization of SPD-5 and...
Multivalent coiled-coil interactions enable full-scale centrosome assembly and strength
Rios et al. investigate the structural effects of PLK-1 phosphorylation on the centrosome protein SPD-5. They reveal molec...
An inside job: New roles for ApoE at the lipid droplet
Feringa and van der Kant discuss novel findings from the Cohen group implicating a role for the Alzheimer’s risk gene ApoE...
Correction: Cell cycle controls long-range calcium signaling in the regenerating epidermis
Vol. 222, No. 7 | https://doi.org/10.1083/jcb.202302095 | April 27, 2023
Broken chromosomes heading into mitosis: More than one way to patch a flat tire
Messer and Fox discuss new work that highlights the multiple molecular mechanisms by which cells respond to mitosis-relate...
Correction: Fission-independent compartmentalization of mitochondria during budding yeast cell division
Vol. 223, No. 3 | https://doi.org/10.1083/jcb.202211048 | January 5, 2024
Positioning centrioles and centrosomes
Hannaford and Rusan summarize the direct and indirect transport mechanisms by which centrosomes and centrioles are positio...
A farnesyl-dependent structural role for CENP-E in expansion of the fibrous corona
Wu et al. show that the mitotic kinesin CENP-E promotes full expansion of the outer layer of the kinetochore known as the ...
Membrane contact site detection (MCS-DETECT) reveals dual control of rough mitochondria–ER contacts
Application of the subpixel resolution membrane contact site (MCS) detection algorithm, MCS-DETECT, to 3D STED super-resol...
Bridging condensins mediate compaction of mitotic chromosomes
Forte et al. report simulations revealing that bridging condensins are important to condense chromosomes into mitotic cyli...
Lipid exchange at ER–trans-Golgi contact sites governs polarized cargo sorting
Kovács et al. report that the lipid transporter OSBP regulates apicobasal cargo sorting. By regulating PI(4)P and choleste...
Nedd4-2-dependent regulation of astrocytic Kir4.1 and Connexin43 controls neuronal network activity
Altas et al. demonstrate that astrocytic ion channel proteostasis coordinated by an E3 ubiquitin ligase Nedd4-2 is of part...
Formation and function of multiciliated cells
Lyu et al. summarize the current knowledge of multiciliogenesis by which the respiratory tract, brain ventricles, and repr...
Margarete Heck (1959–2023): Cell biologist, geneticist, and incandescent social spark
Margarete M.S. Heck, professor of cell biology and genetics, University of Edinburgh, died peacefully at home amid her lov...
Long live lamins
Jin and Worman discuss work from Hasper and colleagues, who discovered that turnover of lamin A/C and progerin is substant...
Capping protein regulators of actin assembly in budding yeast
Cooper discusses work from the Di Pietro group demonstrating that multiple CPI-motif proteins play distinct synergistic an...
Sugar-free synapses run on mitochondrial Sirtuin 3
Metabolic plasticity of neurons ensures their activity continues when glucose is limited. Walsh and Simon discuss new work...
Cell polarity changes in cancer initiation and progression
Peglion and Etienne-Manneville discuss new insights into the pleiotropic effects of cell polarity alteration in cancer pat...
Correction: PLK4 self-phosphorylation drives the selection of a single site for procentriole assembly
Vol. 222, No. 12 | https://doi.org/10.1083/jcb.202301069 | September 29, 2023
The 2024 JCB Early Career Advisory Board
In 2019, JCB launched its inaugural Early Career Advisory Board in an effort to address the needs of an important demograp...
Endocytic myosin-1 is a force-insensitive, power-generating motor
Pedersen, Snoberger et al. measure the force sensitivity of the yeast endocytic myosin-1 called Myo5 and find that it is m...
Tejas functions as a core component in nuage assembly and precursor processing in Drosophila piRNA biogenesis
Lin et al. report that Tejas, an essential component of piRNA pathway, plays a key role in recruiting Vasa (Vas) and Spind...
NME3 binds to phosphatidic acid and mediates PLD6-induced mitochondrial tethering
It is unclear whether and how mitochondrial fusion is selected. In this work, Su et al. demonstrate that NME3 functions as...
The minus-end depolymerase KIF2A drives flux-like treadmilling of γTuRC-uncapped microtubules
Henkin, Brito, et al. reconstitute in vitro a functional module elucidating previously poorly understood mechanisms of pol...
Mitochondrial double membrane fission: A mystery solved?
Westermann discusses two related studies examining a novel protein that plays a key role in mitochondrial division.
Nanoscale architect: Illuminating the key organizer of the fruit fly’s sensory world
Lu and Gelfand preview work from Song et al., which reveals a role for the microtubule-binding protein DCX-EMAP in the 3D ...
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