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Associations between clustering of hypoglycemic symptoms, psychological traits, and problem-solving abilities in adults with type 1 diabetes: baseline data analysis of the PR-IAH study
Associations between clustering of hypoglycemic symptoms, psychological traits, and problem-solving abilities in adults with type 1 diabetes: baseline data analysis of the PR-IAH study
Precision medicine in diabetes care requires a dedicated focus on hypoglycemic symptoms. This study explored the associati...
Long-term efficacy and safety of early sitagliptin initiation in individuals with type 2 diabetes: an extension of the SPIKE study
Long-term efficacy and safety of early sitagliptin initiation in individuals with type 2 diabetes: an extension of the SPIKE study
We previously demonstrated that sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, slowed down the progression of ca...
Plantar pressure and shear stress during gait in people with diabetic neuropathy
Plantar pressure and shear stress during gait in people with diabetic neuropathy
Diabetic foot ulcers are a leading cause of lower extremity amputations, significantly affecting the quality of life. Exce...
Unraveling the pathophysiology of type 2 diabetes with a new selectively bred animal model, the Oikawa-Nagao mouse
Unraveling the pathophysiology of type 2 diabetes with a new selectively bred animal model, the Oikawa-Nagao mouse
Type 2 diabetes (T2D) is a polygenic disease, and the development of animal models by selective breeding is crucial for un...
Pathophysiological hallmarks in type 2 diabetes heterogeneity (review)
Pathophysiological hallmarks in type 2 diabetes heterogeneity (review)
The mechanistic complexity in type 2 diabetes (T2DM) is primarily responsible for the degrees of heterogeneity and develop...
Long-term effects of esaxerenone in patients with type 2 diabetes, diabetic kidney disease, and hypertension (JDDM77)
Long-term effects of esaxerenone in patients with type 2 diabetes, diabetic kidney disease, and hypertension (JDDM77)
This clinical study assessed the three-year, long-term effects of esaxerenone, a non-steroidal aldosterone receptor blocke...
Regulation of glucose metabolism by incretins: implications for treatment of type 2 diabetes
Regulation of glucose metabolism by incretins: implications for treatment of type 2 diabetes
Gastrointestinal hormones that potentiate insulin secretion from pancreatic β-cells are called incretins. Glucose-dep...
Protective effect of CK2 against endoplasmic reticulum stress in pancreatic β cells
Protective effect of CK2 against endoplasmic reticulum stress in pancreatic β cells
Endoplasmic reticulum (ER) stress due to obesity or systemic insulin resistance is an important pathogenic factor that cou...
Differentiation, reduction, and proliferation of pancreatic β-cells and their regulatory factors
Differentiation, reduction, and proliferation of pancreatic β-cells and their regulatory factors
The prevalence of diabetes has increased rapidly in recent years, and many types of therapeutic agents have been developed...
Glycemic variability and quality of life outcomes after changing to hybrid closed-loop system in Japanese individuals with type 1 diabetes using a conventional predictive low-glucose suspended insulin pump system
Glycemic variability and quality of life outcomes after changing to hybrid closed-loop system in Japanese individuals with type 1 diabetes using a conventional predictive low-glucose suspended insulin pump system
The hybrid closed-loop (HCL) system, Medtronic MiniMed™ 770G, has been available for use by Japanese individuals wit...
Depression in pregnant non-diabetic women and women with gestational diabetes in Bangladesh—a comparative study based on multiple logistic regression
Depression in pregnant non-diabetic women and women with gestational diabetes in Bangladesh—a comparative study based on multiple logistic regression
Depression and gestational diabetes mellitus (GDM) pose significant challenges during pregnancy. Limited literature exists...
Mitochondrial DNA 3243 mutation may be associated with positivity of zinc transporter 8 autoantibody in cases of slowly progressive type 1 diabetes mellitus
Mitochondrial DNA 3243 mutation may be associated with positivity of zinc transporter 8 autoantibody in cases of slowly progressive type 1 diabetes mellitus
Slowly progressive type 1 diabetes mellitus (SPIDDM), solely positive for zinc transporter 8 autoantibody (ZnT8A) is rare,...
Insulin resistant diabetes mellitus in a girl with mild Rabson-Mendenhall syndrome: efficacy of sodium glucose co-transporter 2 inhibitor
Insulin resistant diabetes mellitus in a girl with mild Rabson-Mendenhall syndrome: efficacy of sodium glucose co-transporter 2 inhibitor
We report a beneficial effect of a sodium glucose co-transporter 2 (SGLT2) inhibitor in the management of insulin resistan...
Systemic lupus erythematosus and pulmonary tuberculosis in a patient developing acute-onset type 1 diabetes
Systemic lupus erythematosus and pulmonary tuberculosis in a patient developing acute-onset type 1 diabetes
A 73-year-old Japanese woman was admitted to our hospital with anorexia, weight loss, and fever. A few weeks prior to admi...
Practice guideline: Statement regarding treatment for suspected slowly progressive type 1 diabetes (SPIDDM; probable) cases (English Version)
Practice guideline: Statement regarding treatment for suspected slowly progressive type 1 diabetes (SPIDDM; probable) cases (English Version)
Insulin treatment should be introduced in patients with slowly progressive type 1 diabetes (SPIDDM; definite), according t...
Factors associated with the recurrence of foot ulcers in Japanese patients with diabetes
Factors associated with the recurrence of foot ulcers in Japanese patients with diabetes
Patients with diabetes are frequently complicated with diabetic foot ulcers (DFUs) which are vulnerable to recurrence afte...
Slow progression of type 1 diabetes associated with pembrolizumab and lenvatinib combination therapy in a patient with probable slowly progressive type 1 diabetes mellitus and endometrial cancer
Slow progression of type 1 diabetes associated with pembrolizumab and lenvatinib combination therapy in a patient with probable slowly progressive type 1 diabetes mellitus and endometrial cancer
A 58-year-old woman with a body mass index of 26.4 kg/m2 was referred because of high glycated hemoglobin (HbA1c)...
Prevalence and risk factors for skeletal muscle mass loss in individuals with type 1 diabetes
Prevalence and risk factors for skeletal muscle mass loss in individuals with type 1 diabetes
This study aimed to the investigate prevalence and factors associated with reduced skeletal muscle mass in non-elderly adu...
Blood cell HbA1c measured by enzymatic assay show higher than whole blood HbA1c in patients with iron deficiency anemia
Blood cell HbA1c measured by enzymatic assay show higher than whole blood HbA1c in patients with iron deficiency anemia
In Japan, most HbA1c measurements by enzymatic assays or immunoassays represent the HbA1c levels in the blood cell fractio...
Acetonemic vomiting: a potential complication of treatment with glucagon-like peptide-1 receptor agonists especially in lean type 2 diabetes patients
Acetonemic vomiting: a potential complication of treatment with glucagon-like peptide-1 receptor agonists especially in lean type 2 diabetes patients
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are now widely used for treating type 2 diabetes mellitus (T2DM) and...
Impact of angiotensin receptor neprilysin inhibitor on serum C-peptide levels in patients with type 2 diabetes
Impact of angiotensin receptor neprilysin inhibitor on serum C-peptide levels in patients with type 2 diabetes
Sacubitril/valsartan, an angiotensin receptor neprilysin inhibitor (ARNI), is becoming more common in the treatment of hea...
Dapagliflozin treatment decreases visceral and subcutaneous adipose tissue: a systematic review and meta-analysis
Dapagliflozin treatment decreases visceral and subcutaneous adipose tissue: a systematic review and meta-analysis
Sodium-glucose co-transporter-2 inhibitors (SGLT2i) have been shown to reduce visceral (VAT) and subcutaneous (SAT) adipos...
Cost-effective analysis focused on hypoglycemia of intermittent-scanning continuous glucose monitoring in type 1 diabetes adults: a ISCHIA randomized clinical trial
Cost-effective analysis focused on hypoglycemia of intermittent-scanning continuous glucose monitoring in type 1 diabetes adults: a ISCHIA randomized clinical trial
This study aimed to compare the economic value of intermittent-scanning continuous glucose monitoring (isCGM) with self-mo...
Effects of laparoscopic sleeve gastrectomy on weight loss and metabolic improvement in subjects aged 65 years or older: a subanalysis of J-SMART study
Effects of laparoscopic sleeve gastrectomy on weight loss and metabolic improvement in subjects aged 65 years or older: a subanalysis of J-SMART study
To investigate the effect of weight loss and metabolic improvement after laparoscopic sleeve gastrectomy (LSG) in older ad...
Long-term effect of short-term exercise instructions in Japanese patients with type 2 diabetes: observation study after randomized controlled study
Long-term effect of short-term exercise instructions in Japanese patients with type 2 diabetes: observation study after randomized controlled study
To clarify the long-term effects of short-term exercise instructions by physical therapists in Japanese people with type 2...
Analysis of thyroid autoantibodies and the risk of insulin depletion after the clinical onset of acute-onset type 1 diabetes in Japanese patients: the TIDE-J study
Analysis of thyroid autoantibodies and the risk of insulin depletion after the clinical onset of acute-onset type 1 diabetes in Japanese patients: the TIDE-J study
Type 1 diabetes is often accompanied by autoimmune thyroid disease. We aimed to investigate the clinical characteristics o...
Validity of the international physical activity questionnaire short form for assessing physical activity in Japanese adults with type 1 diabetes
Validity of the international physical activity questionnaire short form for assessing physical activity in Japanese adults with type 1 diabetes
To examine the validity of the International Physical Activity Questionnaire short form (IPAQ-SF) against an objective met...
Prognostic factors for hospitalization for severe hypoglycemia without diabetes mellitus: a retrospective study
Prognostic factors for hospitalization for severe hypoglycemia without diabetes mellitus: a retrospective study
Patients with non-diabetic hypoglycemia have a poorer prognosis than those with diabetic hypoglycemia. However, the factor...
Two cases of conventional fulminant type 1 diabetes: following the depletion process of endogenous insulin secretion and literature review
Two cases of conventional fulminant type 1 diabetes: following the depletion process of endogenous insulin secretion and literature review
Fulminant type 1 diabetes (FT1D) is a rapidly progressive form of diabetes in which the endogenous capacity to secrete ins...
Calculated estimation of the metabolic clearance rate of insulin measured by glucose clamp examination in out-patient clinical practice
Calculated estimation of the metabolic clearance rate of insulin measured by glucose clamp examination in out-patient clinical practice
A subpopulation of Japanese patients with type 2 diabetes mellitus (T2DM) who have elevated insulin clearance (IC) exists....
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