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Recent advances of exosomes in age-related macular degeneration
Recent advances of exosomes in age-related macular degeneration
Exosomes are 30–150 nm extracellular vesicles that are secreted by almost all types of cells. Exosomes contain a vari...
BuShen HuoXue decoction improves fertility through intestinal hsp-16.2-mediated heat-shock signaling pathway in Caenorhabditis elegans
BuShen HuoXue decoction improves fertility through intestinal hsp-16.2-mediated heat-shock signaling pathway in Caenorhabditis elegans
Introduction: BuShen HuoXue (BSHX) decoction is commonly used in the clinical treatment of premature ovarian failure becau...
Elexacaftor-tezacaftor-ivacaftor in patients with cystic fibrosis ineligible for clinical trials: a 24-week observational study
Elexacaftor-tezacaftor-ivacaftor in patients with cystic fibrosis ineligible for clinical trials: a 24-week observational study
Introduction: Seminal clinical trials with the triple combination of elexacaftor-tezacaftor-ivacaftor (ETI) demonstrated c...
Circular RNAs in ferroptosis: regulation mechanism and potential clinical application in disease
Circular RNAs in ferroptosis: regulation mechanism and potential clinical application in disease
Ferroptosis, an iron-dependent non-apoptotic form of cell death, is reportedly involved in the pathogenesis of various dis...
Influencing factors of medication literacy among community-dwelling older adult patients with hypertension: a study based on social learning theory
Influencing factors of medication literacy among community-dwelling older adult patients with hypertension: a study based on social learning theory
Objective: This study aimed to examine the factors affecting medication literacy in community-dwelling older adults with h...
Efficacy and safety of Gushen Antai Pills combined with dydrogesterone in the treatment of threatened miscarriage: a systematic review and meta-analysis
Efficacy and safety of Gushen Antai Pills combined with dydrogesterone in the treatment of threatened miscarriage: a systematic review and meta-analysis
Background: Despite some progress has been made in the pathogenesis and treatment of threatened miscarriage (TM), conventi...
Selected cutaneous adverse events in patients treated with ICI monotherapy and combination therapy: a retrospective pharmacovigilance study and meta-analysis
Selected cutaneous adverse events in patients treated with ICI monotherapy and combination therapy: a retrospective pharmacovigilance study and meta-analysis
Introduction: Cutaneous adverse events are commonly reported immune-related adverse events (irAEs), some of which are seri...
Purpurolide C-based microneedle promotes macrophages-mediated diabetic wound healing via inhibiting TLR4-MD2 dimerization and MYD88 phosphorylation
DiabetesWound healingPurpurolide CLiposome and GelMA-based microneedle patchesMacrophage polarizationInflammationDrug deli...
Characterization of the depsidone gene cluster reveals etherification, decarboxylation and multiple halogenations as tailoring steps in depsidone assembly
Available online 1 June 2023Author links open overlay panel, , , , AbstractDepsides and depsidones have attracted attentio...
Discovery of novel aporphine alkaloid derivative as potent TLR2 antagonist reversing macrophage polarization and neutrophil infiltration against acute inflammation
Available online 1 June 2023Author links open overlay panel, , , , , AbstractToll-like receptor 2 (TLR2) mediated macropha...
Erratum to “Identification of anti-Mycobacterium tuberculosis agents targeting the interaction of bacterial division proteins FtsZ and SepF” [Acta Pharmaceutica Sinica B 13 (2023) 2056-2070]
Available online 1 June 2023Author links open overlay panelHongjuan Zhang a 1, Ying Chen a 1, Yu Zhang a, Luyao Qiao a, Xi...
Small molecules targeting protein‒protein interactions for cancer therapy
Available online 1 June 2023Author links open overlay panel, , , , , , AbstractProtein‒protein interactions (PPIs) are fun...
Zinc Ortho Methyl Carbonodithioate Improved Pre and Post-Synapse Memory Impairment via SIRT1/p-JNK Pathway against Scopolamine in Adult Mice
Zinc Ortho Methyl Carbonodithioate Improved Pre and Post-Synapse Memory Impairment via SIRT1/p-JNK Pathway against Scopolamine in Adult Mice
Alzheimer’s disease (AD) is globally recognized as a prominent cause of dementia for which efficient treatment is st...
Targeting intestinal microecology: potential intervention strategies of traditional Chinese medicine for managing hypertension
Targeting intestinal microecology: potential intervention strategies of traditional Chinese medicine for managing hypertension
Hypertension has become one of the major public health problems in the world. At present, the pathogenesis of hypertension...
Computational and experimental pharmacology to decode the efficacy of Theobroma cacao L. against doxorubicin-induced organ toxicity in EAC-mediated solid tumor-induced mice
Computational and experimental pharmacology to decode the efficacy of Theobroma cacao L. against doxorubicin-induced organ toxicity in EAC-mediated solid tumor-induced mice
Background and objective: Doxorubicin is extensively utilized chemotherapeutic drug, and it causes damage to the heart, li...
Safety and effectiveness of the combination of remimazolam tosilate and propofol in gastroscopy: a multicenter, randomized controlled, single-blind clinical trial
Safety and effectiveness of the combination of remimazolam tosilate and propofol in gastroscopy: a multicenter, randomized controlled, single-blind clinical trial
Remimazolam tosilate (RT) is a new short-acting γ-aminobutyric acid A (GABAA) receptors agonist. However, its optimal use ...
Development of a UPLC–MS/MS method for simultaneous therapeutic drug monitoring of anti-hepatocellular carcinoma drugs and analgesics in human plasma
Development of a UPLC–MS/MS method for simultaneous therapeutic drug monitoring of anti-hepatocellular carcinoma drugs and analgesics in human plasma
In hepatocellular carcinoma treatment, sorafenib, oxaliplatin, 5-fluorouracil, capecitabine, lenvatinib, and donafenib are...
Tanshinone IIA promotes vascular normalization and boosts Sorafenib’s anti-hepatoma activity via modulating the PI3K-AKT pathway
Tanshinone IIA promotes vascular normalization and boosts Sorafenib’s anti-hepatoma activity via modulating the PI3K-AKT pathway
Introduction: Angiogenesis is an essential feature of liver cancer. Tumor hypoxia results from abnormal vessel architectur...
Gut microbiome-mediated mechanisms in aging-related diseases: are probiotics ready for prime time?
Gut microbiome-mediated mechanisms in aging-related diseases: are probiotics ready for prime time?
Chronic low-grade inflammation affects health and is associated with aging and age-related diseases. Dysregulation of the ...
Yiwei decoction promotes apoptosis of gastric cancer cells through spleen-derived exosomes
Yiwei decoction promotes apoptosis of gastric cancer cells through spleen-derived exosomes
Yiwei decoction (YWD) is a formula of traditional Chinese medicine (TCM) that is clinically effective for the prevention a...
Efficacy and safety of pharmacotherapy for recurrent high-grade glioma: a systematic review and network meta-analysis
Efficacy and safety of pharmacotherapy for recurrent high-grade glioma: a systematic review and network meta-analysis
Objective: To compare the efficacy and safety of treatments for patients with recurrent high-grade gliomas.Methods: Electr...
Triptolide enhances carboplatin-induced apoptosis by inhibiting nucleotide excision repair (NER) activity in melanoma
Triptolide enhances carboplatin-induced apoptosis by inhibiting nucleotide excision repair (NER) activity in melanoma
Introduction: Carboplatin (CBP) is a DNA damaging drug used to treat various cancers, including advanced melanoma. Yet we ...
The elucidation of the anti-inflammatory mechanism of EMO in rheumatoid arthritis through an integrative approach combining bioinformatics and experimental verification
The elucidation of the anti-inflammatory mechanism of EMO in rheumatoid arthritis through an integrative approach combining bioinformatics and experimental verification
Introduction: Emodin (EMO), a natural derivative of the anthraquinone family mainly extracted from rhubarb (Rheum palmatum...
Expert consensus on neurodevelopmental outcomes in pregnancy pharmacovigilance studies
Expert consensus on neurodevelopmental outcomes in pregnancy pharmacovigilance studies
Background: Exposure in utero to certain medications can disrupt processes of fetal development, including brain developme...
Effectiveness and safety of tenofovir amibufenamide and its comparison with tenofovir alafenamide in patients with chronic hepatitis B: results from a retrospective real-world study
Effectiveness and safety of tenofovir amibufenamide and its comparison with tenofovir alafenamide in patients with chronic hepatitis B: results from a retrospective real-world study
Background/aim: Tenofovir amibufenamide (TMF) has shown potent antiviral efficacy in randomized clinical studies. This stu...
Traditional Chinese medicine use is associated with lower risk of pneumonia in patients with systemic lupus erythematosus: a population-based retrospective cohort study
Traditional Chinese medicine use is associated with lower risk of pneumonia in patients with systemic lupus erythematosus: a population-based retrospective cohort study
Objectives: To investigate the association between traditional Chinese medicine (TCM) therapy and the risk of pneumonia in...
Single-cell RNA sequencing revealed subclonal heterogeneity and gene signatures of gemcitabine sensitivity in pancreatic cancer
Single-cell RNA sequencing revealed subclonal heterogeneity and gene signatures of gemcitabine sensitivity in pancreatic cancer
Introduction: Resistance to gemcitabine is common and critically limits its therapeutic efficacy in pancreatic ductal aden...
Arum palaestinum delays hepatocellular carcinoma proliferation through the PI3K-AKT-mTOR signaling pathway and exhibits anticoagulant effects with antimicrobial properties
Arum palaestinum delays hepatocellular carcinoma proliferation through the PI3K-AKT-mTOR signaling pathway and exhibits anticoagulant effects with antimicrobial properties
Background:Arum palaestinum Boiss (AP) is a wild plant in Palestine whose leaves have a long history as food and medicine ...
Factors associated with underreporting of adverse drug reactions by patients: a systematic review
Factors associated with underreporting of adverse drug reactions by patients: a systematic review
Spontaneous reporting is the most used method to monitor post-marketing safety information. Although patient involvement i...
Factors that influence patient and public adverse drug reaction reporting: a systematic review using the theoretical domains framework
Factors that influence patient and public adverse drug reaction reporting: a systematic review using the theoretical domains framework
Only 5–10% of all adverse drug reactions (ADRs) are reported. Mechanisms to support patient and public reporting off...
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