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Recent advances of exosomes in age-related macular degeneration
Recent advances of exosomes in age-related macular degeneration
Exosomes are 30–150 nm extracellular vesicles that are secreted by almost all types of cells. Exosomes contain a vari...
BuShen HuoXue decoction improves fertility through intestinal hsp-16.2-mediated heat-shock signaling pathway in Caenorhabditis elegans
BuShen HuoXue decoction improves fertility through intestinal hsp-16.2-mediated heat-shock signaling pathway in Caenorhabditis elegans
Introduction: BuShen HuoXue (BSHX) decoction is commonly used in the clinical treatment of premature ovarian failure becau...
Elexacaftor-tezacaftor-ivacaftor in patients with cystic fibrosis ineligible for clinical trials: a 24-week observational study
Elexacaftor-tezacaftor-ivacaftor in patients with cystic fibrosis ineligible for clinical trials: a 24-week observational study
Introduction: Seminal clinical trials with the triple combination of elexacaftor-tezacaftor-ivacaftor (ETI) demonstrated c...
Circular RNAs in ferroptosis: regulation mechanism and potential clinical application in disease
Circular RNAs in ferroptosis: regulation mechanism and potential clinical application in disease
Ferroptosis, an iron-dependent non-apoptotic form of cell death, is reportedly involved in the pathogenesis of various dis...
Small molecules targeting protein‒protein interactions for cancer therapy
Available online 1 June 2023Author links open overlay panel, , , , , , AbstractProtein‒protein interactions (PPIs) are fun...
Targeting intestinal microecology: potential intervention strategies of traditional Chinese medicine for managing hypertension
Targeting intestinal microecology: potential intervention strategies of traditional Chinese medicine for managing hypertension
Hypertension has become one of the major public health problems in the world. At present, the pathogenesis of hypertension...
Tanshinone IIA promotes vascular normalization and boosts Sorafenib’s anti-hepatoma activity via modulating the PI3K-AKT pathway
Tanshinone IIA promotes vascular normalization and boosts Sorafenib’s anti-hepatoma activity via modulating the PI3K-AKT pathway
Introduction: Angiogenesis is an essential feature of liver cancer. Tumor hypoxia results from abnormal vessel architectur...
Gut microbiome-mediated mechanisms in aging-related diseases: are probiotics ready for prime time?
Gut microbiome-mediated mechanisms in aging-related diseases: are probiotics ready for prime time?
Chronic low-grade inflammation affects health and is associated with aging and age-related diseases. Dysregulation of the ...
Yiwei decoction promotes apoptosis of gastric cancer cells through spleen-derived exosomes
Yiwei decoction promotes apoptosis of gastric cancer cells through spleen-derived exosomes
Yiwei decoction (YWD) is a formula of traditional Chinese medicine (TCM) that is clinically effective for the prevention a...
Efficacy and safety of pharmacotherapy for recurrent high-grade glioma: a systematic review and network meta-analysis
Efficacy and safety of pharmacotherapy for recurrent high-grade glioma: a systematic review and network meta-analysis
Objective: To compare the efficacy and safety of treatments for patients with recurrent high-grade gliomas.Methods: Electr...
Triptolide enhances carboplatin-induced apoptosis by inhibiting nucleotide excision repair (NER) activity in melanoma
Triptolide enhances carboplatin-induced apoptosis by inhibiting nucleotide excision repair (NER) activity in melanoma
Introduction: Carboplatin (CBP) is a DNA damaging drug used to treat various cancers, including advanced melanoma. Yet we ...
Expert consensus on neurodevelopmental outcomes in pregnancy pharmacovigilance studies
Expert consensus on neurodevelopmental outcomes in pregnancy pharmacovigilance studies
Background: Exposure in utero to certain medications can disrupt processes of fetal development, including brain developme...
Single-cell RNA sequencing revealed subclonal heterogeneity and gene signatures of gemcitabine sensitivity in pancreatic cancer
Single-cell RNA sequencing revealed subclonal heterogeneity and gene signatures of gemcitabine sensitivity in pancreatic cancer
Introduction: Resistance to gemcitabine is common and critically limits its therapeutic efficacy in pancreatic ductal aden...
Factors associated with underreporting of adverse drug reactions by patients: a systematic review
Factors associated with underreporting of adverse drug reactions by patients: a systematic review
Spontaneous reporting is the most used method to monitor post-marketing safety information. Although patient involvement i...