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Differential Cytokine Responses of APOE3 and APOE4 Blood–brain Barrier Cell Types to SARS-CoV-2 Spike Proteins
Differential Cytokine Responses of APOE3 and APOE4 Blood–brain Barrier Cell Types to SARS-CoV-2 Spike Proteins
SARS-CoV-2 spike proteins have been shown to cross the blood–brain barrier (BBB) in mice and affect the integrity of...
Editorial overview: Special issue on “Rheumatology: Therapeutic advances for autoimmune and musculoskeletal diseases”
Editorial overview: Special issue on “Rheumatology: Therapeutic advances for autoimmune and musculoskeletal diseases”
Kristi Kuhn, MD, PhD, is the Scoville Endowed Chair and Head of the Division of Rheumatology and an associate professor of...
Homologous Recombination Repair Gene Mutations in Prostate Cancer: Prevalence and Clinical Value
Homologous Recombination Repair Gene Mutations in Prostate Cancer: Prevalence and Clinical Value
Despite advances in our understanding of the molecular landscape of prostate cancer and the development of novel biomarker...
Application of biological agents in the treatment of anti-neutrophil cytoplasmic antibody-associated vasculitis
Application of biological agents in the treatment of anti-neutrophil cytoplasmic antibody-associated vasculitis
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) has been traditionally treated using glucocorticoi...
Natural compound Alternol actives multiple endoplasmic reticulum stress-responding pathways contributing to cell death
Natural compound Alternol actives multiple endoplasmic reticulum stress-responding pathways contributing to cell death
Background: Alternol is a small molecular compound isolated from the fermentation of a mutant fungus obtained from Taxus b...
Better together: nanoscale co-delivery systems of therapeutic agents for high-performance cancer therapy
Better together: nanoscale co-delivery systems of therapeutic agents for high-performance cancer therapy
Combination therapies can enhance the sensitivity of cancer to drugs, lower drug doses, and reduce side effects in cancer ...
MASMDDI: multi-layer adaptive soft-mask graph neural network for drug-drug interaction prediction
MASMDDI: multi-layer adaptive soft-mask graph neural network for drug-drug interaction prediction
Accurately predicting Drug-Drug Interaction (DDI) is a critical and challenging aspect of the drug discovery process, part...
Enhanced amphiregulin exposure promotes modulation of the high grade serous ovarian cancer tumor immune microenvironment
Enhanced amphiregulin exposure promotes modulation of the high grade serous ovarian cancer tumor immune microenvironment
High grade serous ovarian cancer (HGSOC) is a lethal gynecologic malignancy in which chemoresistant recurrence rates remai...
Editorial: Education in pharmacology of anti-cancer drugs: 2023
Editorial: Education in pharmacology of anti-cancer drugs: 2023
In the fight against cancer, education stands as a powerful ally. Understanding the pharmacology of anti-cancer drugs has ...
Positive Effect of 6-Gingerol on Functional Plasticity of Microglia in a rat Model of LPS-induced Depression
Positive Effect of 6-Gingerol on Functional Plasticity of Microglia in a rat Model of LPS-induced Depression
Neuroinflammation has emerged as a crucial factor in the development of depression. Despite the well-known anti-inflammato...
Development and Delphi consensus validation of the Medication-Related Fall screening and scoring tool
Development and Delphi consensus validation of the Medication-Related Fall screening and scoring tool
Falls are a significant public health problem and constitute a major cause of injuries and mortality. Risk factors for fal...
In the heart and beyond: Mitochondrial dysfunction in heart failure with preserved ejection fraction (HFpEF)
In the heart and beyond: Mitochondrial dysfunction in heart failure with preserved ejection fraction (HFpEF)
Volume 76, June 2024, 102461Author links open overlay panel, AbstractHeart failure with preserved ejection fraction (HFpEF...
European Achondroplasia Forum Practical Considerations for Following Adults with Achondroplasia
European Achondroplasia Forum Practical Considerations for Following Adults with Achondroplasia
Achondroplasia is a lifelong condition requiring lifelong management. There is consensus that infants and children with ac...
Does an Aspirin a Day Take the MASLD Away?
Does an Aspirin a Day Take the MASLD Away?
Although aspirin is deeply rooted in the most ancient history of medicine, the mechanism of action of this drug was only i...
florio® HAEMO: A Longitudinal Survey of Patient Preference, Adherence and Wearable Functionality in Central Europe
florio® HAEMO: A Longitudinal Survey of Patient Preference, Adherence and Wearable Functionality in Central Europe
florio® HAEMO is a hemophilia treatment monitoring application (app) offering activity tracking and wearable device c...
Potential use of antioxidants for the treatment of chronic inflammatory diseases
Potential use of antioxidants for the treatment of chronic inflammatory diseases
The excessive production of various reactive oxidant species over endogenous antioxidant defense mechanisms leads to the d...
Antiseizure properties of fenamate NSAIDs determined in mature human stem-cell derived neuroglial circuits
Antiseizure properties of fenamate NSAIDs determined in mature human stem-cell derived neuroglial circuits
Repeated and uncontrolled seizures in epilepsy result in brain cell loss and neural inflammation. Current anticonvulsants ...
Identification and validation of a platelet-related signature for predicting survival and drug sensitivity in multiple myeloma
Identification and validation of a platelet-related signature for predicting survival and drug sensitivity in multiple myeloma
Background: Significant progress has been achieved in the management of multiple myeloma (MM) by implementing high-dose th...
Cross-species variability in lobular geometry and cytochrome P450 hepatic zonation: insights into CYP1A2, CYP2D6, CYP2E1 and CYP3A4
Cross-species variability in lobular geometry and cytochrome P450 hepatic zonation: insights into CYP1A2, CYP2D6, CYP2E1 and CYP3A4
There is a lack of systematic research exploring cross-species variation in liver lobular geometry and zonation patterns o...