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Editorial: Disease-on-a-chip: from point-of-care to personalized medicine
Editorial: Disease-on-a-chip: from point-of-care to personalized medicine
Miniaturization has played a pivotal role in driving innovation in microfluidic devices, particularly in their application...
Phase-specific differential regulation of mechanical allodynia in a murine model of neuropathic pain by progesterone
Phase-specific differential regulation of mechanical allodynia in a murine model of neuropathic pain by progesterone
Progesterone has been shown to have neuroprotective capabilities against a wide range of nervous system injuries, however ...
Drug repositioning in thyroid cancer treatment: the intriguing case of anti-diabetic drugs
Drug repositioning in thyroid cancer treatment: the intriguing case of anti-diabetic drugs
Cancer represents the main cause of death worldwide. Thyroid cancer (TC) shows an overall good rate of survival, however t...
Research hotspots and trend analysis of cell transplantation in traumatic spinal cord injury: a bibliometric and visualized analysis
Research hotspots and trend analysis of cell transplantation in traumatic spinal cord injury: a bibliometric and visualized analysis
Background: A traumatic spinal cord injury (TSCI) can lead to severe nerve damage and disability. Cell transplantation the...
From the CONSORT to the ConPhyMP statement and beyond—how to ascertain best practice
From the CONSORT to the ConPhyMP statement and beyond—how to ascertain best practice
With the implementation of the ConPhyMP reporting tool as an element of peer review in Frontiers in Pharmacology, Section ...
A phase I study to evaluate the safety, tolerability, and pharmacokinetics of a novel, potent GABA analog HSK16149 in healthy Chinese subjects
A phase I study to evaluate the safety, tolerability, and pharmacokinetics of a novel, potent GABA analog HSK16149 in healthy Chinese subjects
Purpose: HSK16149 is a novel, potent gamma-aminobutyric acid (GABA) analog for the treatment of neuropathic pain. This stu...
Psoriasis comorbid with atherosclerosis meets in lipid metabolism
Psoriasis comorbid with atherosclerosis meets in lipid metabolism
Psoriasis (PSO) is a common skin disease affecting approximately 1%–3% of the population, and the incidence rate is increa...
Case report: SAF-189s is a potent inhibitor in a lorlatinib-resistant NSCLC patient with acquired compound mutations ALK L1196M and D1203N
Case report: SAF-189s is a potent inhibitor in a lorlatinib-resistant NSCLC patient with acquired compound mutations ALK L1196M and D1203N
Acquired anaplastic lymphoma kinase (ALK) mutation is the major resistant mechanism to ALK tyrosine kinase inhibitors (TKI...
Herbal formulas for detoxification and dredging collaterals in treating carotid atherosclerosis: a systematic review and meta-analysis
Herbal formulas for detoxification and dredging collaterals in treating carotid atherosclerosis: a systematic review and meta-analysis
Objective: To systematically evaluate the efficacy and safety of the Chinese medicine detoxification and dredging collater...
Physical activity influences adherence to pharmacological treatments in patients with severe mental disorders: results from the multicentric, randomized controlled LIFESTYLE trial
Physical activity influences adherence to pharmacological treatments in patients with severe mental disorders: results from the multicentric, randomized controlled LIFESTYLE trial
Introduction: Poor adherence to pharmacological treatment is frequent in people with severe mental disorders and it often ...
Preventative and therapeutic potential of tocotrienols on musculoskeletal diseases in ageing
Preventative and therapeutic potential of tocotrienols on musculoskeletal diseases in ageing
Musculoskeletal health is paramount in an ageing population susceptible to conditions such as osteoporosis, arthritis and ...
Putting bicarbonate on the spot: pharmacological insights for CFTR correction in the airway epithelium
Putting bicarbonate on the spot: pharmacological insights for CFTR correction in the airway epithelium
Introduction: Cystic fibrosis (CF) is caused by defective Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) prote...
Efficacy and safety of Chinese medicine injections in combination with docetaxel and cisplatin for non-small cell lung cancer: a network meta-analysis
Efficacy and safety of Chinese medicine injections in combination with docetaxel and cisplatin for non-small cell lung cancer: a network meta-analysis
Background: Non-small cell lung cancer (NSCLC) poses a serious threat to human health. Several clinical studies have repor...
Effect of Danshen for improving clinical outcomes in patients with bladder cancer: a retrospective, population-based study
Effect of Danshen for improving clinical outcomes in patients with bladder cancer: a retrospective, population-based study
Introduction: Traditional Chinese Medicine (TCM) has a broad application in healthcare, with Danshen being a notable herb ...
Valproic acid for agitation in the intensive care unit: an observational study of psychiatric consults
Valproic acid for agitation in the intensive care unit: an observational study of psychiatric consults
Agitation is a common clinical problem encountered in the intensive care unit (ICU). Treatment options are based on clinic...
Correction to: Nationwide Study of Real-World Treatment Patterns and Clinical Outcomes in Patients with Metastatic Urothelial Carcinoma in Hungary
Correction to: Nationwide Study of Real-World Treatment Patterns and Clinical Outcomes in Patients with Metastatic Urothelial Carcinoma in Hungary
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International ...
Matching-Adjusted Indirect Comparison of Recombinant Factor IX Albumin Fusion Protein Versus Recombinant Factor IX Fc Fusion Protein for Weekly Prophylactic Treatment of Hemophilia B
Matching-Adjusted Indirect Comparison of Recombinant Factor IX Albumin Fusion Protein Versus Recombinant Factor IX Fc Fusion Protein for Weekly Prophylactic Treatment of Hemophilia B
Prophylactic treatment of hemophilia B with recombinant factor IX (rFIX) molecules with enhanced pharmac...
The Effects of Safinamide in Chinese and Non-Chinese Patients with Parkinson’s Disease
The Effects of Safinamide in Chinese and Non-Chinese Patients with Parkinson’s Disease
Ethnicity differences are an important determinant in the clinical manifestation of Parkinson’s disease (PD), but th...
Embedding cultural competency and cultural humility in undergraduate pharmacist initial education and training: a qualitative exploration of pharmacy student perspectives
Embedding cultural competency and cultural humility in undergraduate pharmacist initial education and training: a qualitative exploration of pharmacy student perspectives
Emphasis has been placed upon embedding equity, diversity and inclusion within the initial education and training of healt...
Universal Lipid Screening in Adolescents to Identify Familial Hypercholesterolemia in a Large Healthcare System
Universal Lipid Screening in Adolescents to Identify Familial Hypercholesterolemia in a Large Healthcare System
Familial Hypercholesterolemia (FH) is a common treatable monogenic disorder found throughout the world with an estimated p...
Antinociceptive and antiinflammatory activities of crude leave extract and solvent fractions of Commelina latifolia Hochst. ex C.B.Clarke (Commelinaceae) leaves in murine model
Antinociceptive and antiinflammatory activities of crude leave extract and solvent fractions of Commelina latifolia Hochst. ex C.B.Clarke (Commelinaceae) leaves in murine model
Ethnopharmacological relevance: In the past, Ethiopian traditional medicine employed the leaves of the native Commelina la...
PdMo nanoflowers for endogenous/exogenous-stimulated nanocatalytic therapy
PdMo nanoflowers for endogenous/exogenous-stimulated nanocatalytic therapy
The clinical application of reactive oxygen species (ROS)-mediated tumor treatment has been critically limited by ineffici...
Discovery of potential WEE1 inhibitors via hybrid virtual screening
Discovery of potential WEE1 inhibitors via hybrid virtual screening
G2/M cell cycle checkpoint protein WEE1 kinase is a promising target for inhibiting tumor growth. Although various WEE1 in...
Regulatory mechanisms of autophagy-related ncRNAs in bone metabolic diseases
Regulatory mechanisms of autophagy-related ncRNAs in bone metabolic diseases
Bone metabolic diseases have been tormented and are plaguing people worldwide due to the lack of effective and thorough me...
A synthetic notch (synNotch) system linking intratumoral immune-cancer cell communication to a synthetic blood biomarker assay
A synthetic notch (synNotch) system linking intratumoral immune-cancer cell communication to a synthetic blood biomarker assay
Introduction: Cellular immunotherapy has greatly improved cancer treatment in recent years. For instance, chimeric antigen...
Berberine-microbiota interplay: orchestrating gut health through modulation of the gut microbiota and metabolic transformation into bioactive metabolites
Berberine-microbiota interplay: orchestrating gut health through modulation of the gut microbiota and metabolic transformation into bioactive metabolites
Berberine is an isoquinoline alkaloid found in plants. It presents a wide range of pharmacological activities, including a...
The antibacterial effectiveness of lavender essential oil against methicillin-resistant Staphylococcus aureus: a systematic review
The antibacterial effectiveness of lavender essential oil against methicillin-resistant Staphylococcus aureus: a systematic review
With the overuse and misuse of antibiotics, multi-drug resistant organisms have become a prominent issue in healthcare, in...
A real-world disproportionality analysis of mepolizumab based on the FDA adverse event reporting system
A real-world disproportionality analysis of mepolizumab based on the FDA adverse event reporting system
Background: Mepolizumab has been approved by the FDA for add-on maintenance treatment of severe asthma with an eosinophili...
Therapeutic applications of CRISPR/Cas9 mediated targeted gene editing in acute lymphoblastic leukemia: current perspectives, future challenges, and clinical implications
Therapeutic applications of CRISPR/Cas9 mediated targeted gene editing in acute lymphoblastic leukemia: current perspectives, future challenges, and clinical implications
Acute Lymphoblastic Leukemia (ALL) is the predominant hematological malignancy in pediatric populations, originating from ...
Pharmacodynamics of zoliflodacin plus doxycycline combination therapy against Neisseria gonorrhoeae in a gonococcal hollow-fiber infection model
Pharmacodynamics of zoliflodacin plus doxycycline combination therapy against Neisseria gonorrhoeae in a gonococcal hollow-fiber infection model
Antimicrobial resistance in the sexually transmitted bacterium Neisseria gonorrhoeae is compromising the management and co...
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