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Systemic Sclerosis Association with Malignancy
Systemic Sclerosis Association with Malignancy
The association of systemic sclerosis (SSc) and cancer is well known from several decades suggesting common genetic and en...
Hair Follicle Melanocytes Initiate Autoimmunity in Alopecia Areata: a Trigger Point
Hair Follicle Melanocytes Initiate Autoimmunity in Alopecia Areata: a Trigger Point
Alopecia areata (AA) is characterized by common non-scarring alopecia due to autoimmune disorders. To date, the specific p...
The Genetics of Eczema Herpeticum
The Genetics of Eczema Herpeticum
Eczema herpeticum (EH) is a viral skin infection caused by herpes simplex virus (HSV) superimposed on eczematous skin lesi...
Pathophysiology, Diagnosis, and Management of Chronic Spontaneous Urticaria: A Literature Review
Pathophysiology, Diagnosis, and Management of Chronic Spontaneous Urticaria: A Literature Review
Chronic spontaneous urticaria (CSU) is characterized by recurring wheals that last 6 weeks or longer without an i...
The Treatment of Primary Immune Deficiencies: Lessons Learned and Future Opportunities
The Treatment of Primary Immune Deficiencies: Lessons Learned and Future Opportunities
Primary immunodeficiency is a group of disorders associated with susceptibility to infectious agents and the development o...
Inflammaging and Osteoarthritis
Inflammaging and Osteoarthritis
Osteoarthritis is a highly prevalent disease particularly in subjects over 65 years of age worldwide. While in th...
Systemic Sclerosis-Specific Antibodies: Novel and Classical Biomarkers
Systemic Sclerosis-Specific Antibodies: Novel and Classical Biomarkers
Disease-specific autoantibodies are considered the most important biomarkers for systemic sclerosis (SSc), due to their ab...
T Cell Abnormalities in X-Linked Agammaglobulinaemia: an Updated Review
T Cell Abnormalities in X-Linked Agammaglobulinaemia: an Updated Review
X-linked agammaglobulinaemia (XLA) is a primary immunodeficiency (PID) resulting from a defect in the B cell development. ...
Correlates of Protection Against Respiratory Syncytial Virus Infection in Infancy
Correlates of Protection Against Respiratory Syncytial Virus Infection in Infancy
The highest morbidity and mortality from respiratory syncytial virus (RSV) infection occurs in young infants. Immunization...
Serum Biomarkers for Autoimmune Hepatitis Type 1: the Case for CD48 and a Review of the Literature
Serum Biomarkers for Autoimmune Hepatitis Type 1: the Case for CD48 and a Review of the Literature
In autoimmune hepatitis (AIH), the persisting inflammation contributes to fibrosis progression, for which conventional bio...
Autoimmunity in Primary Immunodeficiencies (PID)
Autoimmunity in Primary Immunodeficiencies (PID)
Primary immunodeficiency (PID) may impact any component of the immune system. The number of PID and immune dysregulation d...
Microbial Dysbiosis Tunes the Immune Response Towards Allergic Disease Outcomes
Microbial Dysbiosis Tunes the Immune Response Towards Allergic Disease Outcomes
The hygiene hypothesis has been popularized as an explanation for the rapid increase in allergic disease observed over the...
Renal Disease and Systemic Sclerosis: an Update on Scleroderma Renal Crisis
Renal Disease and Systemic Sclerosis: an Update on Scleroderma Renal Crisis
Scleroderma renal crisis (SRC) is a life-threatening complication of systemic sclerosis (SSc) with a mortality of 20% at 6...
Inflammaging and Frailty in Immune-Mediated Rheumatic Diseases: How to Address and Score the Issue
Inflammaging and Frailty in Immune-Mediated Rheumatic Diseases: How to Address and Score the Issue
Frailty is a new concept in rheumatology that can help identify people more likely to have less favorable outcomes. Sarcop...
Autoantibodies and Cancer Association: the Case of Systemic Sclerosis and Dermatomyositis
Autoantibodies and Cancer Association: the Case of Systemic Sclerosis and Dermatomyositis
Several rheumatic diseases have a perplexing association with cancer. Unraveling this mysterious connection is likely to p...
Infections or Vaccines Associated with Finkelstein-Seidlmayer Vasculitis: Systematic Review
Infections or Vaccines Associated with Finkelstein-Seidlmayer Vasculitis: Systematic Review
Finkelstein-Seidlmayer vasculitis, also referred to as acute hemorrhagic edema of young children, is a rare small-vessel l...
Allergy to Local Anesthetics is a Rarity: Review of Diagnostics and Strategies for Clinical Management
Allergy to Local Anesthetics is a Rarity: Review of Diagnostics and Strategies for Clinical Management
Local anesthetics (LA) are commonly used in procedures and in topical agents for pain management. With the increasing use ...
Clinical Treatment Options in Scleroderma: Recommendations and Comprehensive Review
Clinical Treatment Options in Scleroderma: Recommendations and Comprehensive Review
There are two major clinical subsets of scleroderma: (i) systemic sclerosis (SSc) is a complex systemic autoimmune disorde...
B Cell Aberrance in Lupus: the Ringleader and the Solution
B Cell Aberrance in Lupus: the Ringleader and the Solution
Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease with high heterogeneity but the common characteriz...
Thoracic Involvement in Systemic Autoimmune Rheumatic Diseases: Pathogenesis and Management
Thoracic Involvement in Systemic Autoimmune Rheumatic Diseases: Pathogenesis and Management
Thoracic involvement is one of the main determinants of morbidity and mortality in patients with autoimmune rheumatic dise...
Diagnostic Modalities in Primary Immunodeficiency
Diagnostic Modalities in Primary Immunodeficiency
As the field of inborn errors of immunity expands, providers continually update and fine-tune their diagnostic approach an...
Dupilumab-Associated Adverse Events During Treatment of Allergic Diseases
Dupilumab-Associated Adverse Events During Treatment of Allergic Diseases
Among the new biological therapies for atopic diseases, dupilumab is a fully human monoclonal antibody directed against IL...
The Airway Microbiome-IL-17 Axis: a Critical Regulator of Chronic Inflammatory Disease
The Airway Microbiome-IL-17 Axis: a Critical Regulator of Chronic Inflammatory Disease
The respiratory tract is home to a diverse microbial community whose influence on local and systemic immune responses is o...