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Vernal Keratoconjunctivitis: A Systematic Review
Vernal Keratoconjunctivitis: A Systematic Review
Vernal keratoconjunctivitis (VKC) is a chronic, bilateral corneal and conjunctival problem which typically presents in you...
Treatable Traits in Systemic Sclerosis
Treatable Traits in Systemic Sclerosis
Systemic sclerosis (SSc) is a chronic systemic disease within the spectrum of connective tissue diseases, specifically cha...
Hypersensitivity Reactions to Taxanes: A Comprehensive and Systematic Review of the Efficacy and Safety of Desensitization
Hypersensitivity Reactions to Taxanes: A Comprehensive and Systematic Review of the Efficacy and Safety of Desensitization
Taxanes in the treatment of cancer are associated with a significant incidence of hypersensitivity reactions, which may pr...
Shared Pathogenicity Features and Sequences between EBV, SARS-CoV-2, and HLA Class I Molecule-binding Motifs with a Potential Role in Autoimmunity
Shared Pathogenicity Features and Sequences between EBV, SARS-CoV-2, and HLA Class I Molecule-binding Motifs with a Potential Role in Autoimmunity
Epstein-Barr virus (EBV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are extraordinary in their abili...
Environmental Risk Factors, Protective Factors, and Biomarkers for Allergic Rhinitis: A Systematic Umbrella Review of the Evidence
Environmental Risk Factors, Protective Factors, and Biomarkers for Allergic Rhinitis: A Systematic Umbrella Review of the Evidence
Many potential environmental risk factors, protective factors, and biomarkers of AR have been published, but so far, the s...
During Sepsis and COVID-19, the Pro-Inflammatory and Anti-Inflammatory Responses Are Concomitant
During Sepsis and COVID-19, the Pro-Inflammatory and Anti-Inflammatory Responses Are Concomitant
The most severe forms of COVID-19 share many features with bacterial sepsis and have thus been considered to be a viral se...
γδ T Cells and Allergic Diseases
γδ T Cells and Allergic Diseases
Gamma–delta (γδ) T cells play an essential role in allergic diseases and have emerged as a potential treat...
COVID-19, Coronavirus Vaccines, and Possible Association with Lipschütz Vulvar Ulcer: A Systematic Review
COVID-19, Coronavirus Vaccines, and Possible Association with Lipschütz Vulvar Ulcer: A Systematic Review
Lipschütz genital ulcer is a self-limited, non-sexually acquired disorder characterized by the sudden onset of a few ...
Perspectives on Mycophenolate Mofetil in the Management of Autoimmunity
Perspectives on Mycophenolate Mofetil in the Management of Autoimmunity
Before becoming a cornerstone in the treatment of numerous immune-mediated diseases, mycophenolate mofetil (MMF) was first...
Food Allergy Labeling Laws: International Guidelines for Residents and Travelers
Food Allergy Labeling Laws: International Guidelines for Residents and Travelers
The prevalence of food allergies varies by country, as does each country’s food allergen labeling. While labeling la...
Single-Cell Analysis of Patients with Axial Spondyloarthritis After Anti-TNFα Treatment: Experimental Data and Review of the Literature
Single-Cell Analysis of Patients with Axial Spondyloarthritis After Anti-TNFα Treatment: Experimental Data and Review of the Literature
Axial spondyloarthritis (Ax-SpA) is a chronic inflammatory disease that predominantly affects the axial joints and is most...
Impact of Air Pollution on Atopic Dermatitis: A Comprehensive Review
Impact of Air Pollution on Atopic Dermatitis: A Comprehensive Review
Air pollution is associated with multiple health problems worldwide, contributing to increased morbidity and mortality. At...
The Evolving Landscape of Fecal Microbial Transplantation
The Evolving Landscape of Fecal Microbial Transplantation
The human gastrointestinal tract houses an enormous microbial ecosystem. Recent studies have shown that the gut microbiota...
A Review of Persistent Post-COVID Syndrome (PPCS)
A Review of Persistent Post-COVID Syndrome (PPCS)
Persistent post-COVID syndrome, also referred to as long COVID, is a pathologic entity, which involves persistent physical...
Epigenetic Dysregulation in Autoimmune and Inflammatory Skin Diseases
Epigenetic Dysregulation in Autoimmune and Inflammatory Skin Diseases
Epigenetics is the study of heritable, reversible gene expression patterns that do not originate from alterations in the D...
New Mechanistic Advances in FcεRI-Mast Cell–Mediated Allergic Signaling
New Mechanistic Advances in FcεRI-Mast Cell–Mediated Allergic Signaling
Mast cells originate from the CD34+/CD117+ hematopoietic progenitors in the bone marrow, migrate into circulation, and ult...
Systemic Sclerosis Association with Malignancy
Systemic Sclerosis Association with Malignancy
The association of systemic sclerosis (SSc) and cancer is well known from several decades suggesting common genetic and en...
Hair Follicle Melanocytes Initiate Autoimmunity in Alopecia Areata: a Trigger Point
Hair Follicle Melanocytes Initiate Autoimmunity in Alopecia Areata: a Trigger Point
Alopecia areata (AA) is characterized by common non-scarring alopecia due to autoimmune disorders. To date, the specific p...
The Genetics of Eczema Herpeticum
The Genetics of Eczema Herpeticum
Eczema herpeticum (EH) is a viral skin infection caused by herpes simplex virus (HSV) superimposed on eczematous skin lesi...
Pathophysiology, Diagnosis, and Management of Chronic Spontaneous Urticaria: A Literature Review
Pathophysiology, Diagnosis, and Management of Chronic Spontaneous Urticaria: A Literature Review
Chronic spontaneous urticaria (CSU) is characterized by recurring wheals that last 6 weeks or longer without an i...
The Treatment of Primary Immune Deficiencies: Lessons Learned and Future Opportunities
The Treatment of Primary Immune Deficiencies: Lessons Learned and Future Opportunities
Primary immunodeficiency is a group of disorders associated with susceptibility to infectious agents and the development o...
A Summary on the Genetics of Systemic Lupus Erythematosus, Rheumatoid Arthritis, Systemic Sclerosis, and Sjögren’s Syndrome
A Summary on the Genetics of Systemic Lupus Erythematosus, Rheumatoid Arthritis, Systemic Sclerosis, and Sjögren’s Syndrome
Systemic lupus erythematosus, systemic sclerosis, rheumatoid arthritis, and Sjögren’s syndrome are four major a...
Inflammaging and Osteoarthritis
Inflammaging and Osteoarthritis
Osteoarthritis is a highly prevalent disease particularly in subjects over 65 years of age worldwide. While in th...
Systemic Sclerosis-Specific Antibodies: Novel and Classical Biomarkers
Systemic Sclerosis-Specific Antibodies: Novel and Classical Biomarkers
Disease-specific autoantibodies are considered the most important biomarkers for systemic sclerosis (SSc), due to their ab...
T Cell Abnormalities in X-Linked Agammaglobulinaemia: an Updated Review
T Cell Abnormalities in X-Linked Agammaglobulinaemia: an Updated Review
X-linked agammaglobulinaemia (XLA) is a primary immunodeficiency (PID) resulting from a defect in the B cell development. ...
Correlates of Protection Against Respiratory Syncytial Virus Infection in Infancy
Correlates of Protection Against Respiratory Syncytial Virus Infection in Infancy
The highest morbidity and mortality from respiratory syncytial virus (RSV) infection occurs in young infants. Immunization...
Germinal Center-Related G Protein-Coupled Receptors in Antibody-Mediated Autoimmune Skin Diseases: from Basic Research to Clinical Trials
Germinal Center-Related G Protein-Coupled Receptors in Antibody-Mediated Autoimmune Skin Diseases: from Basic Research to Clinical Trials
Germinal center (GC) reaction greatly contributes to the humoral immune response, which begins in lymph nodes or other sec...
Serum Biomarkers for Autoimmune Hepatitis Type 1: the Case for CD48 and a Review of the Literature
Serum Biomarkers for Autoimmune Hepatitis Type 1: the Case for CD48 and a Review of the Literature
In autoimmune hepatitis (AIH), the persisting inflammation contributes to fibrosis progression, for which conventional bio...
Autoimmunity in Primary Immunodeficiencies (PID)
Autoimmunity in Primary Immunodeficiencies (PID)
Primary immunodeficiency (PID) may impact any component of the immune system. The number of PID and immune dysregulation d...
Microbial Dysbiosis Tunes the Immune Response Towards Allergic Disease Outcomes
Microbial Dysbiosis Tunes the Immune Response Towards Allergic Disease Outcomes
The hygiene hypothesis has been popularized as an explanation for the rapid increase in allergic disease observed over the...
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