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Ketone monoester ingestion increases post-exercise serum erythropoietin concentrations in healthy men
Ketone monoester ingestion increases post-exercise serum erythropoietin concentrations in healthy men
Intravenous ketone body infusion can increase erythropoietin (EPO) concentrations, but responses to ketone monoester inges...
High resolution analysis of the cytosolic Ca2+ events in beta cell collectives in situ
High resolution analysis of the cytosolic Ca2+ events in beta cell collectives in situ
The release of peptide hormones is predominantly regulated by a transient increase in cytosolic Ca2+ concentration ([Ca2+]...
Inosine, Gut Microbiota, and Cancer Immunometabolism
Inosine, Gut Microbiota, and Cancer Immunometabolism
This article briefly reviews cancer immunity and the role of gut microbiota in carcinogenesis, followed by an understandin...
Obesity and Chronic Kidney Disease
Obesity and Chronic Kidney Disease
The prevalence of obesity has increased dramatically during the past decades, which has been a major health problem. Since...
Glucagon receptor blockage inhibits β-cell dedifferentiation through FoxO1
Glucagon receptor blockage inhibits β-cell dedifferentiation through FoxO1
Glucagon-secreting pancreatic α-cells play pivotal roles in the development of diabetes. Glucagon promotes insulin secreti...
Decreased adiponectin/leptin ratio relates to insulin resistance in adults with obesity
Decreased adiponectin/leptin ratio relates to insulin resistance in adults with obesity
Adipose tissue dysfunction is a key mechanism that leads to adiposity-based chronic disease. This study aimed to investiga...
Coordination of Pancreatic Islet Rhythmic Activity by Delayed Negative Feedback
Coordination of Pancreatic Islet Rhythmic Activity by Delayed Negative Feedback
Secretion of insulin from the pancreas is pulsatile, driven by intrinsic oscillations within individual islets of Langerha...
Genetic ablation of the preptin coding portion of IGF2 impairs pancreatic function in female mice
Genetic ablation of the preptin coding portion of IGF2 impairs pancreatic function in female mice
Preptin is a 34-amino acid peptide derived from the E-peptide of pro-insulin-like growth factor 2 and is co-secreted with ...
Glucagon Receptor Signaling at White Adipose Tissue Does Not Regulate Lipolysis
Glucagon Receptor Signaling at White Adipose Tissue Does Not Regulate Lipolysis
Although the physiologic role of glucagon receptor signaling in the liver is well defined, the impact of glucagon receptor...
Insulin Infusion Decreases Medium-Sized Extracellular Vesicles in Adults with Metabolic Syndrome
Insulin Infusion Decreases Medium-Sized Extracellular Vesicles in Adults with Metabolic Syndrome
Elevated extracellular vesicles (EVs) are associated with glucose dysmetabolism. However, the effects of insulin on EVs an...
Intestinal FFA3 Mediates Obesogenic Effects in Mice on a Western Diet
Intestinal FFA3 Mediates Obesogenic Effects in Mice on a Western Diet
Free fatty acid receptor 3 (FFA3) is a recently-deorphanized G protein-coupled receptor. Its ligands are short-chain fatty...