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Human pancreatic capillaries and nerve fibers persist in type 1 diabetes despite beta cell loss
Human pancreatic capillaries and nerve fibers persist in type 1 diabetes despite beta cell loss
The autonomic nervous system regulates pancreatic function. Islet capillaries are essential for the extension of axonal pr...
Impact of tyrosine kinase inhibitors on glucose control and insulin regulation in chronic myeloid leukemia patients
Impact of tyrosine kinase inhibitors on glucose control and insulin regulation in chronic myeloid leukemia patients
Treatment with tyrosine kinase inhibitors (TKIs), especially nilotinib, often results in hyperglycemia, which may further ...
A reduction of skeletal muscle DHA content does not result in impaired whole-body glucose tolerance or skeletal muscle basal insulin signaling in healthy mice
A reduction of skeletal muscle DHA content does not result in impaired whole-body glucose tolerance or skeletal muscle basal insulin signaling in healthy mice
Delta-6 desaturase (D6D), encoded by the Fads2 gene, catalyzes the first step in the conversion of alpha-linolenic acid to...
A physiologic increase in brain glucagon action alters the hepatic gluconeogenic glycogenolytic ratio but not glucagon's overall effect on glucose production
A physiologic increase in brain glucagon action alters the hepatic gluconeogenic glycogenolytic ratio but not glucagon's overall effect on glucose production
It has been proposed that brain glucagon action inhibits glucagon stimulated hepatic glucose production (HGP), which may e...
The role of preproglucagon peptides in regulating β-cell morphology and responses to streptozotocin-induced diabetes
The role of preproglucagon peptides in regulating β-cell morphology and responses to streptozotocin-induced diabetes
Insulin secretion from β-cells is tightly regulated by local signaling from preproglucagon (Gcg) products from neighboring...
Deletion of GABAB receptors from Kiss1 cells affects glucose homeostasis without altering reproduction in male mice.
Deletion of GABAB receptors from Kiss1 cells affects glucose homeostasis without altering reproduction in male mice.
Kisspeptin and gamma amino butyric acid (GABA), synthesized in the central nervous system, are critical for reproduction. ...
Ketone monoester ingestion increases postexercise serum erythropoietin concentrations in healthy men
Ketone monoester ingestion increases postexercise serum erythropoietin concentrations in healthy men
To our knowledge, this study was the first to assess the effects of ketone monoester ingestion on erythropoietin concentra...
PERK/ATF4-dependent expression of the stress response protein REDD1 promotes proinflammatory cytokine expression in the heart of obese mice
PERK/ATF4-dependent expression of the stress response protein REDD1 promotes proinflammatory cytokine expression in the heart of obese mice
Interplay between endoplasmic reticulum stress and inflammation contributes to cardiovascular disease progression. The stu...
Investigating dual inhibition of ACC and CD36 for the treatment of non-alcoholic fatty liver disease in mice
Investigating dual inhibition of ACC and CD36 for the treatment of non-alcoholic fatty liver disease in mice
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. Dysregulation in hepatic lip...
Inhibition of the endocannabinoid system reverses obese phenotype in aged mice and partly restores skeletal muscle function
Inhibition of the endocannabinoid system reverses obese phenotype in aged mice and partly restores skeletal muscle function
Sarcopenia, the age-related loss of skeletal muscle mass is associated with lipid accumulation and anabolic resistance; ph...
Fibroblast Growth Factor 21 as a Potential Master Regulator in Metabolic Disorders
Fibroblast Growth Factor 21 as a Potential Master Regulator in Metabolic Disorders
Fibroblast growth factor 21 (FGF21) is an endocrine hormone that controls key metabolic processes and induces the synthesi...
Maternal obesity damages the median eminence blood-brain barrier structure and function in the progeny: The beneficial impact of cross-fostering by lean mothers
Maternal obesity damages the median eminence blood-brain barrier structure and function in the progeny: The beneficial impact of cross-fostering by lean mothers
Maternal obesity is an important risk factor for obesity, cardiovascular, and metabolic diseases in the offspring. Studies...
High-resolution analysis of the cytosolic Ca2+ events in β cell collectives in situ
High-resolution analysis of the cytosolic Ca2+ events in β cell collectives in situ
Physiological glucose or ryanodine stimulation of β cell collectives generates a large number of [Ca2+]c events, which can...
Brown adipose tissue is not associated with cachexia or increased mortality in a retrospective study of patients with cancer
Brown adipose tissue is not associated with cachexia or increased mortality in a retrospective study of patients with cancer
While brown fat is strongly associated with a constellation of cardiometabolic benefits in animal models and humans, it ha...
Effects of hypoxic exercise on 24-hour glucose profile and substrate metabolism in overweight and obese men with impaired glucose metabolism
Effects of hypoxic exercise on 24-hour glucose profile and substrate metabolism in overweight and obese men with impaired glucose metabolism
Aim: Hypoxic exercise (HE) may have more pronounced effects on glucose homeostasis than exercise under normoxic conditions...
17α-estradiol, a lifespan-extending compound, attenuates liver fibrosis by modulating collagen turnover rates in male mice
17α-estradiol, a lifespan-extending compound, attenuates liver fibrosis by modulating collagen turnover rates in male mice
Objective: Estrogen signaling is protective against chronic liver diseases, although men and a subset of women are contrai...
Untargeted Metabolomic Profiling Identifies Serum Metabolites Associated with Type 2 Diabetes in a Cross-Sectional Study of the ATBC Study
Untargeted Metabolomic Profiling Identifies Serum Metabolites Associated with Type 2 Diabetes in a Cross-Sectional Study of the ATBC Study
Type 2 diabetes (T2D) is a complex chronic disease with substantial phenotypic heterogeneity affecting millions of individ...
Fat and not sugar as the determining factor for gut microbiota changes, obesity and related metabolic disorders in mice
Fat and not sugar as the determining factor for gut microbiota changes, obesity and related metabolic disorders in mice
Diet-induced obesity contributes to the development of type 2 diabetes, insulin resistance, metabolic inflammation, oxidat...
An effective preselection criterion for MODY with an increasingly positive genetic testing rate by NGS: results from two cohorts of Chinese children
An effective preselection criterion for MODY with an increasingly positive genetic testing rate by NGS: results from two cohorts of Chinese children
We proved the clinical suspicion of maturity-onset diabetes of the young (MODY) according to the comprehensive criterion f...
Endothelin receptor antagonism improves glucose tolerance and adipose tissue inflammation in an experimental model of systemic lupus erythematosus
Endothelin receptor antagonism improves glucose tolerance and adipose tissue inflammation in an experimental model of systemic lupus erythematosus
Endothelin-1 (ET-1) is elevated in patients with systemic lupus erythematosus (SLE), an autoimmune disease characterized b...
Ketone monoester ingestion increases post-exercise serum erythropoietin concentrations in healthy men
Ketone monoester ingestion increases post-exercise serum erythropoietin concentrations in healthy men
Intravenous ketone body infusion can increase erythropoietin (EPO) concentrations, but responses to ketone monoester inges...
High resolution analysis of the cytosolic Ca2+ events in beta cell collectives in situ
High resolution analysis of the cytosolic Ca2+ events in beta cell collectives in situ
The release of peptide hormones is predominantly regulated by a transient increase in cytosolic Ca2+ concentration ([Ca2+]...
Inosine, Gut Microbiota, and Cancer Immunometabolism
Inosine, Gut Microbiota, and Cancer Immunometabolism
This article briefly reviews cancer immunity and the role of gut microbiota in carcinogenesis, followed by an understandin...
Obesity and Chronic Kidney Disease
Obesity and Chronic Kidney Disease
The prevalence of obesity has increased dramatically during the past decades, which has been a major health problem. Since...
An effective pre-selection criterion for MODY with an increasingly positive genetic testing rate by NGS: results from two cohorts of Chinese children
An effective pre-selection criterion for MODY with an increasingly positive genetic testing rate by NGS: results from two cohorts of Chinese children
Purpose: To determine the frequency of maturity-onset diabetes of the young (MODY) in two selected cohorts of Chinese chil...
PERK/ATF4-dependent expression of the stress response protein REDD1 promotes pro-inflammatory cytokine expression in the heart of obese mice
PERK/ATF4-dependent expression of the stress response protein REDD1 promotes pro-inflammatory cytokine expression in the heart of obese mice
Endoplasmic reticulum (ER) stress and inflammation are hallmarks of myocardial impairment. Here we investigated a role for...
Glucagon receptor blockage inhibits β-cell dedifferentiation through FoxO1
Glucagon receptor blockage inhibits β-cell dedifferentiation through FoxO1
Glucagon-secreting pancreatic α-cells play pivotal roles in the development of diabetes. Glucagon promotes insulin secreti...
Loss of hepatic phosphoenolpyruvate carboxykinase 1 dysregulates metabolic responses to acute exercise but enhances adaptations to exercise training in mice
Loss of hepatic phosphoenolpyruvate carboxykinase 1 dysregulates metabolic responses to acute exercise but enhances adaptations to exercise training in mice
Acute exercise increases liver gluconeogenesis to supply glucose to working muscle. Concurrently, elevated liver lipid bre...
A modest change in housing temperature alters whole body energy expenditure and adipocyte thermogenic capacity in mice
A modest change in housing temperature alters whole body energy expenditure and adipocyte thermogenic capacity in mice
Background: Typical vivarium temperatures (20-26°C) induce facultative thermogenesis in mice, a process attributable in pa...
Decreased adiponectin/leptin ratio relates to insulin resistance in adults with obesity
Decreased adiponectin/leptin ratio relates to insulin resistance in adults with obesity
Adipose tissue dysfunction is a key mechanism that leads to adiposity-based chronic disease. This study aimed to investiga...
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