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A diffusion barrier limits nuclear leaks
A diffusion barrier limits nuclear leaks
ESCRT-III seals holes in the nuclear envelope (NE). A study now shows that the Cmp7-directed ESCRT-III cascade that gromme...
Crosstalk between small-cell lung cancer cells and astrocytes mimics brain development to promote brain metastasis
Crosstalk between small-cell lung cancer cells and astrocytes mimics brain development to promote brain metastasis
Brain metastases represent an important clinical problem for patients with small-cell lung cancer (SCLC). However, the mec...
An ESCRT grommet cooperates with a diffusion barrier to maintain nuclear integrity
An ESCRT grommet cooperates with a diffusion barrier to maintain nuclear integrity
The molecular mechanisms by which the endosomal sorting complexes required for transport (ESCRT) proteins contribute to th...
Regulators of mitonuclear balance link mitochondrial metabolism to mtDNA expression
Regulators of mitonuclear balance link mitochondrial metabolism to mtDNA expression
Mitochondrial oxidative phosphorylation (OXPHOS) complexes are assembled from proteins encoded by both nuclear and mitocho...
Curved adhesions mediate cell attachment to soft matrix fibres in three dimensions
Curved adhesions mediate cell attachment to soft matrix fibres in three dimensions
Integrin-mediated focal adhesions are the primary architectures that transmit forces between the extracellular matrix (ECM...
A maternally programmed intergenerational mechanism enables male offspring to make piRNAs from Y-linked precursor RNAs in Drosophila
A maternally programmed intergenerational mechanism enables male offspring to make piRNAs from Y-linked precursor RNAs in Drosophila
In animals, PIWI-interacting RNAs (piRNAs) direct PIWI proteins to silence complementary targets such as transposons. In D...
Defining E3 ligase–substrate relationships through multiplex CRISPR screening
Defining E3 ligase–substrate relationships through multiplex CRISPR screening
Specificity within the ubiquitin–proteasome system is primarily achieved through E3 ubiquitin ligases, but for many ...
Myc-dependent dedifferentiation of Gata6+ epidermal cells resembles reversal of terminal differentiation
Myc-dependent dedifferentiation of Gata6+ epidermal cells resembles reversal of terminal differentiation
Dedifferentiation is the process by which terminally differentiated cells acquire the properties of stem cells. During mou...
How mothers program sons to use their Y chromosomes
How mothers program sons to use their Y chromosomes
In many species, maternally deposited Piwi-interacting RNAs (piRNAs) deliver intergenerational epigenetic information to p...
The opportunities, challenges and progression of a collaborative research project
The opportunities, challenges and progression of a collaborative research project
In this issue, Jason Shapiro, Hsiang-Chun (Jimmy) Chang and colleagues identify a conserved role for the iron-binding hist...
Iron drives anabolic metabolism through active histone demethylation and mTORC1
Iron drives anabolic metabolism through active histone demethylation and mTORC1
All eukaryotic cells require a minimal iron threshold to sustain anabolic metabolism. However, the mechanisms by which cel...
Author Correction: o8G modifications rewire tumoral microRNAs
Authors and AffiliationsDNA and RNA Medicine Division, Center for Applied Medical Research, University of Navarra, Pamplon...
Single-cell multi-omics sequencing of human spermatogenesis reveals a DNA demethylation event associated with male meiotic recombination
Single-cell multi-omics sequencing of human spermatogenesis reveals a DNA demethylation event associated with male meiotic recombination
Human spermatogenesis is a highly ordered process; however, the roles of DNA methylation and chromatin accessibility in th...
DMRT1 drives the human germline forward
DMRT1 drives the human germline forward
The molecular program of human germline commitment remains largely unknown. A new study delineates the multifaceted functi...
DMRT1 regulates human germline commitment
DMRT1 regulates human germline commitment
Germline commitment following primordial germ cell (PGC) specification during early human development establishes an epige...
A research program at the frontier of lipid and membrane biology
A research program at the frontier of lipid and membrane biology
Shirin Bahmanyar is an associate professor of molecular, cellular & developmental biology at Yale University, CT, ...
Pausing pluripotency via RNA methylation
Pausing pluripotency via RNA methylation
Embryonic diapause in development and paused pluripotency in embryonic stem cells result in a state of hypotranscription t...
m6A RNA methylation orchestrates transcriptional dormancy during paused pluripotency
m6A RNA methylation orchestrates transcriptional dormancy during paused pluripotency
Embryos across metazoan lineages can enter reversible states of developmental pausing, or diapause, in response to adverse...
A human peri-gastrulation model
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Collagen fibril self-assembly
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Vitamin K inhibits ferroptosis via VKORC1L1
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STING as a proton channel
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8G modifications rewire tumoral microRNAs
8G modifications rewire tumoral microRNAs
RNA modifications have emerged as key gene regulators. A new study shows that increased levels of reactive oxygen species ...
Widespread 8-oxoguanine modifications of miRNA seeds differentially regulate redox-dependent cancer development
Widespread 8-oxoguanine modifications of miRNA seeds differentially regulate redox-dependent cancer development
Oxidative stress contributes to tumourigenesis by altering gene expression. One accompanying modification, 8-oxoguanine (o...
Depletion of p16high senescent cells for stem cell reprogramming and tissue rejuvenation
Depletion of p16high senescent cells for stem cell reprogramming and tissue rejuvenation
Genetic clearance of p16high senescent cells or the use of senolytics improved the efficacy of stem cell reprogramming in ...
p16High senescence restricts cellular plasticity during somatic cell reprogramming
p16High senescence restricts cellular plasticity during somatic cell reprogramming
Despite advances in four-factor (4F)-induced reprogramming (4FR) in vitro and in vivo, how 4FR interconnects with senescen...
A non-coding m6A reader promotes leukaemia
A non-coding m6A reader promotes leukaemia
Pathways linked to the modification of RNA with N6-methyladenosine (m6A) are known to be involved in initiating and mainta...
Prioritizing diversity will help all of us
Prioritizing diversity will help all of us
Kelly Stevens is an associate professor in the departments of Bioengineering and Laboratory Medicine & Pathology a...
Enhancing reproducibility in human stem cell research
Enhancing reproducibility in human stem cell research
In June 2023, the International Society for Stem Cell Research (ISSCR) released a report detailing standards for human ste...
RBFOX2 recognizes N6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation
RBFOX2 recognizes N6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation
N6-methyladenosine (m6A) methylation can be deposited on chromatin-associated RNAs (caRNAs) by the RNA methyltransferase c...
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