SCI时时刷

search
Author Correction: mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype
Author Correction: mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype
Torsten WuestefeldPresent address: Stem Cell & Regenerative Biology, Genome Institute of Singapore, Singapore, Singapo...
Adding intrinsically disordered proteins to biological ageing clocks
Adding intrinsically disordered proteins to biological ageing clocks
Research into how the young and old differ, and which biomarkers reflect the diverse biological processes underlying agein...
TFAM is an autophagy receptor that limits inflammation by binding to cytoplasmic mitochondrial DNA
TFAM is an autophagy receptor that limits inflammation by binding to cytoplasmic mitochondrial DNA
When cells are stressed, DNA from energy-producing mitochondria can leak out and drive inflammatory immune responses if no...
Polyglutamine-mediated ribotoxicity disrupts proteostasis and stress responses in Huntington’s disease
Polyglutamine-mediated ribotoxicity disrupts proteostasis and stress responses in Huntington’s disease
Huntington’s disease (HD) is a neurodegenerative disorder caused by expansion of a CAG trinucleotide repeat in the H...
Mitochondrial heterogeneity and adaptations to cellular needs
Mitochondrial heterogeneity and adaptations to cellular needs
Although it is well described that mitochondria are at the epicentre of the energy demands of a cell, it is becoming impor...
Phase separation-competent FBL promotes early pre-rRNA processing and translation in acute myeloid leukaemia
Phase separation-competent FBL promotes early pre-rRNA processing and translation in acute myeloid leukaemia
RNA-binding proteins (RBPs) are pivotal in acute myeloid leukaemia (AML), a lethal disease. Although specific phase separa...
It takes two to expand the cortex
It takes two to expand the cortex
Two new landmark studies use innovative and complementary lineage tracing approaches in human cerebral organoids to reveal...
Mammalian IRE1α dynamically and functionally coalesces with stress granules
Mammalian IRE1α dynamically and functionally coalesces with stress granules
Upon endoplasmic reticulum (ER) stress, activation of the ER-resident transmembrane protein kinase/endoribonuclease inosit...
Cell-intrinsic and microenvironmental determinants of metastatic colonization
Cell-intrinsic and microenvironmental determinants of metastatic colonization
Cancer metastasis is a biologically complex process that remains a major challenge in the oncology clinic, accounting for ...
Cerebral organoids display dynamic clonal growth and tunable tissue replenishment
Cerebral organoids display dynamic clonal growth and tunable tissue replenishment
During brain development, neural progenitors expand through symmetric divisions before giving rise to differentiating cell...
ETV4 is a mechanical transducer linking cell crowding dynamics to lineage specification
ETV4 is a mechanical transducer linking cell crowding dynamics to lineage specification
Dynamic changes in mechanical microenvironments, such as cell crowding, regulate lineage fates as well as cell proliferati...
Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation
Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation
Tissue regeneration and maintenance rely on coordinated stem cell behaviours. This orchestration can be impaired by oncoge...
LPCAT1-mediated membrane phospholipid remodelling promotes ferroptosis evasion and tumour growth
LPCAT1-mediated membrane phospholipid remodelling promotes ferroptosis evasion and tumour growth
The mechanisms underlying the dynamic remodelling of cellular membrane phospholipids to prevent phospholipid peroxidation-...
Regulation of mitochondrial fission by fatty acyl-coenzyme A
Regulation of mitochondrial fission by fatty acyl-coenzyme A
We show that the mitochondrial fission proteins MiD49 and MiD51 are activated by fatty acyl-coenzyme A (FA-CoA). FA-CoA bi...
Next questions in autophagy
Next questions in autophagy
Our understanding of the basic mechanisms of autophagy is growing, but many questions remain about the types of autophagy ...
Pooled multicolour tagging for visualizing subcellular protein dynamics
Pooled multicolour tagging for visualizing subcellular protein dynamics
Imaging-based methods are widely used for studying the subcellular localization of proteins in living cells. While routine...
Accelerating data sharing and reuse in volume electron microscopy
Accelerating data sharing and reuse in volume electron microscopy
Volume electron microscopy (vEM) generates large 3D volumes of cells or tissues at nanoscale resolutions, enabling analyse...
Adding a transcription-coupled repair pathway
Adding a transcription-coupled repair pathway
When transcription by RNA polymerase II is stalled by ultraviolet-induced DNA damage, it recruits repair factors, leading ...
Tissue pressure and YAP during organogenesis
Tissue pressure and YAP during organogenesis
Organ morphogenesis begins with proliferation, which results in tissue pressures and site-specific YAP expression, nuclear...
Transcription-coupled DNA–protein crosslink repair by CSB and CRL4CSA-mediated degradation
Transcription-coupled DNA–protein crosslink repair by CSB and CRL4CSA-mediated degradation
DNA–protein crosslinks (DPCs) arise from enzymatic intermediates, metabolism or chemicals like chemotherapeutics. DP...
Endogenous aldehyde-induced DNA–protein crosslinks are resolved by transcription-coupled repair
Endogenous aldehyde-induced DNA–protein crosslinks are resolved by transcription-coupled repair
DNA–protein crosslinks (DPCs) induced by aldehydes interfere with replication and transcription. Hereditary deficien...
Transcription-coupled repair of DNA–protein cross-links depends on CSA and CSB
Transcription-coupled repair of DNA–protein cross-links depends on CSA and CSB
Covalent DNA–protein cross-links (DPCs) are toxic DNA lesions that block replication and require repair by multiple ...
A CRISPRi/a screening platform to study cellular nutrient transport in diverse microenvironments
A CRISPRi/a screening platform to study cellular nutrient transport in diverse microenvironments
Blocking the import of nutrients essential for cancer cell proliferation represents a therapeutic opportunity, but it is u...
Fatty acyl-coenzyme A activates mitochondrial division through oligomerization of MiD49 and MiD51
Fatty acyl-coenzyme A activates mitochondrial division through oligomerization of MiD49 and MiD51
Mitochondrial fission occurs in many cellular processes, but the regulation of fission is poorly understood. We show that ...
CD32 captures committed haemogenic endothelial cells during human embryonic development
CD32 captures committed haemogenic endothelial cells during human embryonic development
During embryonic development, blood cells emerge from specialized endothelial cells, named haemogenic endothelial cells (H...
Transcriptional bodies manage tight resources
Transcriptional bodies manage tight resources
Eukaryotic transcriptional machinery often shows local enrichment in dynamic clusters at sites of high expression. A study...
Lipidomes define immune cell identity
Lipidomes define immune cell identity
Diverse, specialized immune cells defend against pathogens and cancer cells. A new study reveals the comprehensive lipid c...
Judith Campisi (1948–2024)
Judith Campisi (1948–2024)
Judith Campisi, one of the foundational members of the Buck Institute for Research on Aging and an in...
A lipid atlas of human and mouse immune cells provides insights into ferroptosis susceptibility
A lipid atlas of human and mouse immune cells provides insights into ferroptosis susceptibility
The cellular lipidome comprises thousands of unique lipid species. Here, using mass spectrometry-based targeted lipidomics...