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Author Correction: Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2–SP1–SAT1 axis
These authors contributed equally: Divya Murthy, Kuldeep S. Attri, Surendra K. Shukla.Eppley Institute for Research in Can...
Next questions in autophagy
Next questions in autophagy
Our understanding of the basic mechanisms of autophagy is growing, but many questions remain about the types of autophagy ...
Pooled multicolour tagging for visualizing subcellular protein dynamics
Pooled multicolour tagging for visualizing subcellular protein dynamics
Imaging-based methods are widely used for studying the subcellular localization of proteins in living cells. While routine...
Accelerating data sharing and reuse in volume electron microscopy
Accelerating data sharing and reuse in volume electron microscopy
Volume electron microscopy (vEM) generates large 3D volumes of cells or tissues at nanoscale resolutions, enabling analyse...
Adding a transcription-coupled repair pathway
Adding a transcription-coupled repair pathway
When transcription by RNA polymerase II is stalled by ultraviolet-induced DNA damage, it recruits repair factors, leading ...
Tissue pressure and YAP during organogenesis
Tissue pressure and YAP during organogenesis
Organ morphogenesis begins with proliferation, which results in tissue pressures and site-specific YAP expression, nuclear...
Transcription-coupled DNA–protein crosslink repair by CSB and CRL4CSA-mediated degradation
Transcription-coupled DNA–protein crosslink repair by CSB and CRL4CSA-mediated degradation
DNA–protein crosslinks (DPCs) arise from enzymatic intermediates, metabolism or chemicals like chemotherapeutics. DP...
Endogenous aldehyde-induced DNA–protein crosslinks are resolved by transcription-coupled repair
Endogenous aldehyde-induced DNA–protein crosslinks are resolved by transcription-coupled repair
DNA–protein crosslinks (DPCs) induced by aldehydes interfere with replication and transcription. Hereditary deficien...
Transcription-coupled repair of DNA–protein cross-links depends on CSA and CSB
Transcription-coupled repair of DNA–protein cross-links depends on CSA and CSB
Covalent DNA–protein cross-links (DPCs) are toxic DNA lesions that block replication and require repair by multiple ...
A CRISPRi/a screening platform to study cellular nutrient transport in diverse microenvironments
A CRISPRi/a screening platform to study cellular nutrient transport in diverse microenvironments
Blocking the import of nutrients essential for cancer cell proliferation represents a therapeutic opportunity, but it is u...
Fatty acyl-coenzyme A activates mitochondrial division through oligomerization of MiD49 and MiD51
Fatty acyl-coenzyme A activates mitochondrial division through oligomerization of MiD49 and MiD51
Mitochondrial fission occurs in many cellular processes, but the regulation of fission is poorly understood. We show that ...
CD32 captures committed haemogenic endothelial cells during human embryonic development
CD32 captures committed haemogenic endothelial cells during human embryonic development
During embryonic development, blood cells emerge from specialized endothelial cells, named haemogenic endothelial cells (H...
Transcriptional bodies manage tight resources
Transcriptional bodies manage tight resources
Eukaryotic transcriptional machinery often shows local enrichment in dynamic clusters at sites of high expression. A study...
Lipidomes define immune cell identity
Lipidomes define immune cell identity
Diverse, specialized immune cells defend against pathogens and cancer cells. A new study reveals the comprehensive lipid c...
Judith Campisi (1948–2024)
Judith Campisi (1948–2024)
Judith Campisi, one of the foundational members of the Buck Institute for Research on Aging and an in...
A lipid atlas of human and mouse immune cells provides insights into ferroptosis susceptibility
A lipid atlas of human and mouse immune cells provides insights into ferroptosis susceptibility
The cellular lipidome comprises thousands of unique lipid species. Here, using mass spectrometry-based targeted lipidomics...
Transcription bodies regulate gene expression by sequestering CDK9
Transcription bodies regulate gene expression by sequestering CDK9
The localization of transcriptional activity in specialized transcription bodies is a hallmark of gene expression in eukar...
Proliferation-driven mechanical compression induces signalling centre formation during mammalian organ development
Proliferation-driven mechanical compression induces signalling centre formation during mammalian organ development
Localized sources of morphogens, called signalling centres, play a fundamental role in coordinating tissue growth and cell...
Glucose controls lipolysis through Golgi PtdIns4P-mediated regulation of ATGL
Glucose controls lipolysis through Golgi PtdIns4P-mediated regulation of ATGL
Metabolic crosstalk of the major nutrients glucose, amino acids and fatty acids (FAs) ensures systemic metabolic homeostas...
Disordered C-terminal domain drives spatiotemporal confinement of RNAPII to enhance search for chromatin targets
Disordered C-terminal domain drives spatiotemporal confinement of RNAPII to enhance search for chromatin targets
Efficient gene expression requires RNA polymerase II (RNAPII) to find chromatin targets precisely in space and time. How R...
A cell fate decision map reveals abundant direct neurogenesis bypassing intermediate progenitors in the human developing neocortex
A cell fate decision map reveals abundant direct neurogenesis bypassing intermediate progenitors in the human developing neocortex
The human neocortex has undergone strong evolutionary expansion, largely due to an increased progenitor population, the ba...
Cyclophilin A supports translation of intrinsically disordered proteins and affects haematopoietic stem cell ageing
Cyclophilin A supports translation of intrinsically disordered proteins and affects haematopoietic stem cell ageing
Loss of protein function is a driving force of ageing. We have identified peptidyl-prolyl isomerase A (PPIA or cyclophilin...
RIPK1 and necroptosis role in premature ageing
RIPK1 and necroptosis role in premature ageing
Progeria, or premature ageing, is a devastating condition caused by defects in the nuclear envelope and is associated with...
Reconstituting the dynamic steady states of actin networks in vitro
Reconstituting the dynamic steady states of actin networks in vitro
Despite the constant renewal of their components, cellular actin networks maintain their overall appearance, through a sub...
A palmitoylation–depalmitoylation relay spatiotemporally controls GSDMD activation in pyroptosis
A palmitoylation–depalmitoylation relay spatiotemporally controls GSDMD activation in pyroptosis
Gasdermin D (GSDMD) is the executor of pyroptosis, which is important for host defence against pathogen infection. Followi...
Defective prelamin A processing promotes unconventional necroptosis driven by nuclear RIPK1
Defective prelamin A processing promotes unconventional necroptosis driven by nuclear RIPK1
Defects in the prelamin A processing enzyme caused by loss-of-function mutations in the ZMPSTE24 gene are responsible for ...
ACE2-dependent and -independent SARS-CoV-2 entries dictate viral replication and inflammatory response during infection
ACE2-dependent and -independent SARS-CoV-2 entries dictate viral replication and inflammatory response during infection
Excessive inflammation is the primary cause of mortality in patients with severe COVID-19, yet the underlying mechanisms r...
Competence for neural crest induction is controlled by hydrostatic pressure through Yap
Competence for neural crest induction is controlled by hydrostatic pressure through Yap
Embryonic induction is a key mechanism in development that corresponds to an interaction between a signalling and a respon...
Author Correction: Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments
Author Correction: Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments
Michalina JaniszewskaPresent address: Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, USADo...
Distinct pathways drive anterior hypoblast specification in the implanting human embryo
Distinct pathways drive anterior hypoblast specification in the implanting human embryo
Development requires coordinated interactions between the epiblast, which generates the embryo proper; the trophectoderm, ...
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