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FMRP gains mitochondrial fission control
FMRP gains mitochondrial fission control
Mitochondrial fission and fusion are crucial for neurons. The RNA-binding protein FMRP regulates mitochondrial dynamics, i...
Chromatin remodelling in damaged intestinal crypts orchestrates redundant TGFβ and Hippo signalling to drive regeneration
Chromatin remodelling in damaged intestinal crypts orchestrates redundant TGFβ and Hippo signalling to drive regeneration
Cell state dynamics underlying successful tissue regeneration are undercharacterized. In the intestine, damage prompts epi...
FMRP regulates MFF translation to locally direct mitochondrial fission in neurons
FMRP regulates MFF translation to locally direct mitochondrial fission in neurons
Fragile X messenger ribonucleoprotein (FMRP) is a critical regulator of translation, whose dysfunction causes fragile X sy...
Seeing tension in cells
Non-muscle myosin II (NMII) generates contractile forces, and Förster resonance energy transfer (FRET)-based tension senso...
A systemic effect for liver senescence
A systemic effect for liver senescence
A study shows that senescence induced in the liver can spread systemically to precipitate multi-organ dysfunction. The wor...
Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ
Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ
Cellular senescence is not only associated with ageing but also impacts physiological and pathological processes, such as ...
To eat or not to eat
During development, haematopoietic stem and progenitor cells (HSPCs) experiencing high cellular stress produce increased l...
Lipid droplet messengers
Group 2 innate lymphoid cells (ILC2s) serve important roles in airway inflammation in asthma. After being activated, ILC2s...
Cyclic mRNA localization in P-bodies
P-bodies contain a variety of RNA and RNA-binding proteins (RBPs) and modulate their RNA content in response to stress. Ho...
Navigating human embryogenesis through tailored model selection
Rapid advances in stem cell and bioengineering technologies have sparked a revolution in developmental biology, with stem ...
Specialized post-arterial capillaries facilitate adult bone remodelling
Specialized post-arterial capillaries facilitate adult bone remodelling
The vasculature of the skeletal system is crucial for bone formation, homoeostasis and fracture repair, yet the diversity ...
NAT10-mediated mRNA N4-acetylcytidine reprograms serine metabolism to drive leukaemogenesis and stemness in acute myeloid leukaemia
NAT10-mediated mRNA N4-acetylcytidine reprograms serine metabolism to drive leukaemogenesis and stemness in acute myeloid leukaemia
RNA modification has emerged as an important epigenetic mechanism that controls abnormal metabolism and growth in acute my...
Spermidine limits diabetes by modulating RIPK1-mediated cell death and inflammation
Spermidine limits diabetes by modulating RIPK1-mediated cell death and inflammation
We establish a mouse model of progressive diabetes induced by conditional NAT1 deficiency in vascular endothelial cells. N...
Spermidine mediates acetylhypusination of RIPK1 to suppress diabetes onset and progression
Spermidine mediates acetylhypusination of RIPK1 to suppress diabetes onset and progression
It has been established that N-acetyltransferase (murine NAT1 (mNAT1) and human NAT2 (hNAT2)) mediates insulin sensitivity...
Cell state transitions are decoupled from cell division during early embryo development
Cell state transitions are decoupled from cell division during early embryo development
As tissues develop, cells divide and differentiate concurrently. Conflicting evidence shows that cell division is either d...
Spatiotemporal coordination of actin regulators generates invasive protrusions in cell–cell fusion
Spatiotemporal coordination of actin regulators generates invasive protrusions in cell–cell fusion
Invasive membrane protrusions play a central role in a variety of cellular processes. Unlike filopodia, invasive protrusio...
Differential stiffness between brain vasculature and parenchyma promotes metastatic infiltration through vessel co-option
Differential stiffness between brain vasculature and parenchyma promotes metastatic infiltration through vessel co-option
In brain metastasis, cancer cells remain in close contact with the existing vasculature and can use vessels as migratory p...
SERRATE drives phase separation behaviours to regulate m6A modification and miRNA biogenesis
SERRATE drives phase separation behaviours to regulate m6A modification and miRNA biogenesis
The methyltransferase complex (MTC) deposits N6-adenosine (m6A) onto RNA, whereas the microprocessor produces microRNA. Wh...
Building the epigenetic fortress with PRC2.2
Building the epigenetic fortress with PRC2.2
How heterochromatin is established de novo in early embryos is unknown. A study now shows that the sequential recruitment ...
Temporal dynamics of membrane contact sites
Temporal dynamics of membrane contact sites
Cell behaviour changes temporally in response to environmental and metabolic cues. This also applies to membrane contact s...
Distinct H3K9me3 heterochromatin maintenance dynamics govern different gene programmes and repeats in pluripotent cells
Distinct H3K9me3 heterochromatin maintenance dynamics govern different gene programmes and repeats in pluripotent cells
H3K9me3 heterochromatin, established by lysine methyltransferases (KMTs) and compacted by heterochromatin protein 1 (HP1) ...
Cohesin complex oligomerization maintains end-tethering at DNA double-strand breaks
Cohesin complex oligomerization maintains end-tethering at DNA double-strand breaks
DNA double-strand breaks (DSBs) must be repaired to ensure genome stability. Crucially, DSB-ends must be kept together for...
H3K27 dimethylation dynamics reveal stepwise establishment of facultative heterochromatin in early mouse embryos
H3K27 dimethylation dynamics reveal stepwise establishment of facultative heterochromatin in early mouse embryos
Facultative heterochromatin is formed by Polycomb repressive complex 2 (PRC2)-deposited H3K27 trimethylation (H3K27me3) an...
Caspase-2 is a condensate-mediated deubiquitinase in protein quality control
Caspase-2 is a condensate-mediated deubiquitinase in protein quality control
Protein ubiquitination plays a critical role in protein quality control in response to cellular stress. The excessive accu...
Real-time and programmable transcriptome sequencing with PROFIT-seq
Real-time and programmable transcriptome sequencing with PROFIT-seq
The high diversity and complexity of the eukaryotic transcriptome make it difficult to effectively detect specific transcr...
Mitochondrial mechanotransduction through MIEF1 coordinates the nuclear response to forces
Mitochondrial mechanotransduction through MIEF1 coordinates the nuclear response to forces
Tissue-scale architecture and mechanical properties instruct cell behaviour under physiological and diseased conditions, b...
Waste management and cell death in T cells
Waste management and cell death in T cells
After being activated, T lymphocytes must consume fuel for energy and biomaterials to sustain rapid proliferation and diff...
Now it’s getting bloody in cardiac organoids
Now it’s getting bloody in cardiac organoids
Modelling definitive haematopoiesis in organoids has been challenging. A study now develops blood-generating heart-forming...
Ex vivo imaging reveals the spatiotemporal control of ovulation
Ex vivo imaging reveals the spatiotemporal control of ovulation
During ovulation, an egg is released from an ovarian follicle, ready for fertilization. Ovulation occurs inside the body, ...
Role of TFEB lactylation
Lactylation, the covalent modification of lysine with lactate, is a recently identified post-translational modification, a...
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