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A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes
A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes
The pancreatic islets are composed of discrete hormone-producing cells that orchestrate systemic glucose homeostasis. Here...
A single-cell transcriptome atlas profiles early organogenesis in human embryos
A single-cell transcriptome atlas profiles early organogenesis in human embryos
The early window of human embryogenesis is largely a black box for developmental biologists. Here we probed the cellular d...
Regulating enhancer activation
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
Tackling neurodegeneration
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with diverse genetic etiologies. Pathology resulting fr...
Deadly actin collapse by disulfidptosis
Deadly actin collapse by disulfidptosis
Programmed cell death (PCD) enables cells to co-ordinate their exit to benefit the surviving organism. A new study describ...
Author Correction: Multivalent interactions facilitate motor-dependent protein accumulation at growing microtubule plus-ends
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
STING is ESCRTed to degradation by microautophagy
STING is ESCRTed to degradation by microautophagy
Activation of a crucial immune adaptor protein, STING, is tightly regulated by subcellular trafficking, but how it is deac...
Linking SARS-CoV-2 to the circadian clock
Linking SARS-CoV-2 to the circadian clock
A study using a multi-organoid platform and state-of-the-art transcriptional profiling identifies potential therapeutic ta...
A multi-organoid platform identifies CIART as a key factor for SARS-CoV-2 infection
A multi-organoid platform identifies CIART as a key factor for SARS-CoV-2 infection
COVID-19 is a systemic disease involving multiple organs. We previously established a platform to derive organoids and cel...
STING signalling is terminated through ESCRT-dependent microautophagy of vesicles originating from recycling endosomes
STING signalling is terminated through ESCRT-dependent microautophagy of vesicles originating from recycling endosomes
Stimulator of interferon genes (STING) is essential for the type I interferon response against a variety of DNA pathogens....
SARS-CoV-2 causes DNA damage, cellular senescence and inflammation
SARS-CoV-2 causes DNA damage, cellular senescence and inflammation
We discovered that SARS-CoV-2 infection causes DNA damage both in cultured cells and in vivo. Mechanistically, SARS-CoV-2 ...
SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence
SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the RNA virus responsible for the coronavirus disease 2019...
An inclusive and collaborative spirit for global progress in genomics
An inclusive and collaborative spirit for global progress in genomics
Dimple Notani is principal investigator (PI) at the National Centre for Biological Sciences (NCBS) in Bangalore, India, st...
Author Correction: The NSL complex maintains nuclear architecture stability via lamin A/C acetylation
Department of Chromatin Regulation, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, GermanyAdam Karoutas,...
A neurodevelopmental epigenetic programme mediated by SMARCD3–DAB1–Reelin signalling is hijacked to promote medulloblastoma metastasis
A neurodevelopmental epigenetic programme mediated by SMARCD3–DAB1–Reelin signalling is hijacked to promote medulloblastoma metastasis
How abnormal neurodevelopment relates to the tumour aggressiveness of medulloblastoma (MB), the most common type of embryo...
Author Correction: Human induced pluripotent stem cell-derived salivary gland organoids model SARS-CoV-2 infection and replication
Division of Pathology, Department of Oral Diagnostic Sciences, Showa University School of Dentistry, Tokyo, JapanJunichi T...
Niche tension controls exosome production
Niche tension controls exosome production
Extracellular matrix (ECM) stiffening is a hallmark of cancer aggressiveness. Diverse ECM environments can alter the numbe...
Stiff matrix induces exosome secretion to promote tumour growth
Stiff matrix induces exosome secretion to promote tumour growth
Tissue fibrosis and extracellular matrix (ECM) stiffening promote tumour progression. The mechanisms by which ECM regulate...
STAM and Hrs interact sequentially with IFN-α Receptor to control spatiotemporal JAK–STAT endosomal activation
STAM and Hrs interact sequentially with IFN-α Receptor to control spatiotemporal JAK–STAT endosomal activation
Activation of the JAK–STAT pathway by type I interferons (IFNs) requires clathrin-dependent endocytosis of the IFN-&...
Progress and challenges in stem cell biology
Progress and challenges in stem cell biology
Since stem cells were first discovered, researchers have identified distinct stem cell populations in different organs and...
Polarized branched Actin modulates cortical mechanics to produce unequal-size daughters during asymmetric division
Polarized branched Actin modulates cortical mechanics to produce unequal-size daughters during asymmetric division
The control of cell shape during cytokinesis requires a precise regulation of mechanical properties of the cell cortex. On...
Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis
Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis
SLC7A11-mediated cystine uptake suppresses ferroptosis yet promotes cell death under glucose starvation; the nature of the...
Now is the greatest time to be in it
Now is the greatest time to be in it
Daylon James in an associate professor at Weill Cornell Medicine in New York, where his work focuses on reproductive biolo...
Nuclear condensates in YAP1-driven ependymoma
Nuclear condensates in YAP1-driven ependymoma
An ependymoma subtype is driven by fusion proteins related to the transcriptional regulator YAP1. Research now shows that ...
Biologically informed deep learning to query gene programs in single-cell atlases
Biologically informed deep learning to query gene programs in single-cell atlases
The increasing availability of large-scale single-cell atlases has enabled the detailed description of cell states. In par...
Actin-driven chromosome clustering facilitates fast and complete chromosome capture in mammalian oocytes
Actin-driven chromosome clustering facilitates fast and complete chromosome capture in mammalian oocytes
Accurate chromosome segregation during meiosis is crucial for reproduction. Human and porcine oocytes transiently cluster ...
Nuclear condensates of YAP fusion proteins alter transcription to drive ependymoma tumourigenesis
Nuclear condensates of YAP fusion proteins alter transcription to drive ependymoma tumourigenesis
Nuclear localization of HIPPO-YAP fusion proteins has been implicated in supratentorial ependymoma development. Here, unex...
Regenerating the academic pipeline
Regenerating the academic pipeline
Kara McKinley is an assistant professor of stem-cell and regenerative biology at Harvard University. In addition to advanc...
Endothelin signalling drives dermal sheath smooth muscle contraction for hair follicle regression
Endothelin signalling drives dermal sheath smooth muscle contraction for hair follicle regression
Contraction of the hair follicle-lining dermal sheath smooth muscle generates the forces necessary for the tissue remodell...
Dissection of gastric homeostasis in vivo facilitates permanent capture of isthmus-like stem cells in vitro
Dissection of gastric homeostasis in vivo facilitates permanent capture of isthmus-like stem cells in vitro
The glandular stomach is composed of two regenerative compartments termed corpus and antrum, and our understanding of the ...
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