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A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing
A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing
OTX2 is a transcription factor and known driver in medulloblastoma (MB), where it is amplified in a subset of tumours and ...
An E3 ligase and autophagy adaptor regulates tau proteostasis through nested phase separation
An E3 ligase and autophagy adaptor regulates tau proteostasis through nested phase separation
Mutations in the gene encoding the E3 ubiquitin ligase TRIAD3A cause adult-onset neurodegenerative disorders. We reveal th...
RNA glues it all
RNA glues it all
The role of RNA in preserving the integrity and dynamics of membrane-bound organelles remains largely unexplored. A study ...
RNA scaffolds the Golgi ribbon by forming condensates with GM130
RNA scaffolds the Golgi ribbon by forming condensates with GM130
The mammalian Golgi is composed of stacks that are laterally connected into a continuous ribbon-like structure. The integr...
Full-length GSDME mediates pyroptosis independent from cleavage
Full-length GSDME mediates pyroptosis independent from cleavage
Gasdermin (GSDM) family proteins, known as the executors of pyroptosis, undergo protease-mediated cleavage before inducing...
Pressure sensing of lysosomes enables control of TFEB responses in macrophages
Pressure sensing of lysosomes enables control of TFEB responses in macrophages
Polymers are endocytosed and hydrolysed by lysosomal enzymes to generate transportable solutes. While the transport of div...
Neutrophil-derived migrasomes are an essential part of the coagulation system
Neutrophil-derived migrasomes are an essential part of the coagulation system
Migrasomes are organelles that are generated by migrating cells. Here we report the key role of neutrophil-derived migraso...
The autophagy adaptor TRIAD3A promotes tau fibrillation by nested phase separation
The autophagy adaptor TRIAD3A promotes tau fibrillation by nested phase separation
Multiple neurodegenerative diseases are characterized by aberrant proteinaceous accumulations of tau. Here, we report a RI...
Zeb1 mediates EMT/plasticity-associated ferroptosis sensitivity in cancer cells by regulating lipogenic enzyme expression and phospholipid composition
Zeb1 mediates EMT/plasticity-associated ferroptosis sensitivity in cancer cells by regulating lipogenic enzyme expression and phospholipid composition
Therapy resistance and metastasis, the most fatal steps in cancer, are often triggered by a (partial) activation of the ep...
Publisher Correction: Cell-intrinsic and microenvironmental determinants of metastatic colonization
Author notesArthur W. LambertPresent address: Translational Medicine, Oncology R&D, AstraZeneca, Waltham, MA, USAYun Z...
Ferroptosis-like cell death promotes and prolongs inflammation in Drosophila
Ferroptosis-like cell death promotes and prolongs inflammation in Drosophila
Ferroptosis is a distinct form of necrotic cell death caused by overwhelming lipid peroxidation, and emerging evidence ind...
Loss of Kmt2c or Kmt2d drives brain metastasis via KDM6A-dependent upregulation of MMP3
Loss of Kmt2c or Kmt2d drives brain metastasis via KDM6A-dependent upregulation of MMP3
KMT2C and KMT2D, encoding histone H3 lysine 4 methyltransferases, are among the most commonly mutated genes in triple-nega...
A dual role of ERGIC-localized Rabs in TMED10-mediated unconventional protein secretion
A dual role of ERGIC-localized Rabs in TMED10-mediated unconventional protein secretion
Cargo translocation across membranes is a crucial aspect of secretion. In conventional secretion signal peptide-equipped p...
Intertwining roles of R-loops and G-quadruplexes in DNA repair, transcription and genome organization
Intertwining roles of R-loops and G-quadruplexes in DNA repair, transcription and genome organization
R-loops are three-stranded nucleic acid structures that are abundant and widespread across the genome and that have import...
The maintenance of oocytes in the mammalian ovary involves extreme protein longevity
The maintenance of oocytes in the mammalian ovary involves extreme protein longevity
Women are born with all of their oocytes. The oocyte proteome must be maintained with minimal damage throughout the woman&...
Mitochondria and cell death
Mitochondria and cell death
Mitochondria are cellular factories for energy production, calcium homeostasis and iron metabolism, but they also have an ...
CD63 sorts cholesterol into endosomes for storage and distribution via exosomes
CD63 sorts cholesterol into endosomes for storage and distribution via exosomes
Extracellular vesicles such as exosomes are now recognized as key players in intercellular communication. Their role is in...
Author Correction: RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis
Author Correction: RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis
Authors and AffiliationsState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, Sch...
Integrative analysis of ultra-deep RNA-seq reveals alternative promoter usage as a mechanism of activating oncogenic programmes during prostate cancer progression
Integrative analysis of ultra-deep RNA-seq reveals alternative promoter usage as a mechanism of activating oncogenic programmes during prostate cancer progression
Transcription factor (TF) proteins regulate gene activity by binding to regulatory regions, most importantly at gene promo...
Translational control by VARS in melanoma
Translational control by VARS in melanoma
Aminoacyl-tRNA synthetases can promote or suppress cancer progression by regulating codon-dependent translation. A study n...
Valine aminoacyl-tRNA synthetase promotes therapy resistance in melanoma
Valine aminoacyl-tRNA synthetase promotes therapy resistance in melanoma
Transfer RNA dynamics contribute to cancer development through regulation of codon-specific messenger RNA translation. Spe...
Extraembryonic gut endoderm cells undergo programmed cell death during development
Extraembryonic gut endoderm cells undergo programmed cell death during development
Despite a distinct developmental origin, extraembryonic cells in mice contribute to gut endoderm and converge to transcrip...
Exploiting ferroptosis vulnerabilities in cancer
Exploiting ferroptosis vulnerabilities in cancer
Ferroptosis is a distinct lipid peroxidation-dependent form of necrotic cell death. This process has been increasingly con...
Tumour microenvironment programming by an RNA–RNA-binding protein complex creates a druggable vulnerability in IDH-wild-type glioblastoma
Tumour microenvironment programming by an RNA–RNA-binding protein complex creates a druggable vulnerability in IDH-wild-type glioblastoma
Patients with IDH-wild-type glioblastomas have a poor five-year survival rate along with limited treatment efficacy due to...
The glutathione S-transferase Gstt1 drives survival and dissemination in metastases
The glutathione S-transferase Gstt1 drives survival and dissemination in metastases
Identifying the adaptive mechanisms of metastatic cancer cells remains an elusive question in the treatment of metastatic ...
Three-dimensional chromatin reorganization regulates B cell development during ageing
Three-dimensional chromatin reorganization regulates B cell development during ageing
The contribution of three-dimensional genome organization to physiological ageing is not well known. Here we show that lar...
TCF3, TCF12 and distinct enhancers regulate oocyte transcription
TCF3, TCF12 and distinct enhancers regulate oocyte transcription
Oocyte development involves the prolonged and intricate process of building a distinctive transcriptome and epigenome to a...
Mapping putative enhancers in mouse oocytes and early embryos reveals TCF3/12 as key folliculogenesis regulators
Mapping putative enhancers in mouse oocytes and early embryos reveals TCF3/12 as key folliculogenesis regulators
Dynamic epigenomic reprogramming occurs during mammalian oocyte maturation and early development. However, the underlying ...
MFSD1 with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes
MFSD1 with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes
The lysosomal degradation of macromolecules produces diverse small metabolites exported by specific transporters for reuse...
Unfolding emergency calls stress granules to the ER
Unfolding emergency calls stress granules to the ER
Sensing stress within the endoplasmic reticulum (ER), the ER transmembrane protein IRE1α initiates a signal transduct...
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