SCI时时刷

search
Author Correction: The primary cilium and lipophagy translate mechanical forces to direct metabolic adaptation of kidney epithelial cells
Author notesCaterina MiceliPresent address: Center for Autophagy Research, Department of Internal Medicine, University of ...
Telomeres are a life-extending gift
Telomeres are a life-extending gift
Cellular senescence induced by DNA replication and telomere attrition contributes to organ dysfunction, inflammation and i...
Keeping up with the Rag GTPases
Keeping up with the Rag GTPases
The Rag GTPases form the link between extracellular nutrients and the activation of mTORC1. RagA/B and RagC/D have been co...
Insights and opportunities at the crossroads of cancer and neuroscience
Insights and opportunities at the crossroads of cancer and neuroscience
The biological and pathological importance of mutual interactions between the nervous system and cancer have become increa...
A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids
A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids
Amino acid availability controls mTORC1 activity via a heterodimeric Rag GTPase complex that functions as a scaffold at th...
Brain-enriched RagB isoforms regulate the dynamics of mTORC1 activity through GATOR1 inhibition
Brain-enriched RagB isoforms regulate the dynamics of mTORC1 activity through GATOR1 inhibition
Mechanistic target of rapamycin complex 1 (mTORC1) senses nutrient availability to appropriately regulate cellular anaboli...
Stem cell-derived synthetic embryos self-assemble by exploiting cadherin codes and cortical tension
Stem cell-derived synthetic embryos self-assemble by exploiting cadherin codes and cortical tension
Mammalian embryos sequentially differentiate into trophectoderm and an inner cell mass, the latter of which differentiates...
Single-cell atlas of human liver development reveals pathways directing hepatic cell fates
Single-cell atlas of human liver development reveals pathways directing hepatic cell fates
The liver has been studied extensively due to the broad number of diseases affecting its vital functions. However, therape...
An intercellular transfer of telomeres rescues T cells from senescence and promotes long-term immunological memory
An intercellular transfer of telomeres rescues T cells from senescence and promotes long-term immunological memory
The common view is that T lymphocytes activate telomerase to delay senescence. Here we show that some T cells (primarily n...
NRF2 mediates melanoma addiction to GCDH by modulating apoptotic signalling
NRF2 mediates melanoma addiction to GCDH by modulating apoptotic signalling
Tumour dependency on specific metabolic signals has been demonstrated and often guided numerous therapeutic approaches. We...
Massively parallel genomic perturbations with multi-target CRISPR interrogates Cas9 activity and DNA repair at endogenous sites
Massively parallel genomic perturbations with multi-target CRISPR interrogates Cas9 activity and DNA repair at endogenous sites
Here we present an approach that combines a clustered regularly interspaced short palindromic repeats (CRISPR) system that...
Feeding-induced gut autophagy
Share this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a sh...
Deep-learning for microscopy
Share this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a sh...
Finding a chaperone for TDP-43
Finding a chaperone for TDP-43
Aggregation of the RNA-binding protein TDP-43 is commonly observed in neurodegenerative disorders. A new study reveals tha...
Cell identity and plasticity uncoupled
Cell identity and plasticity uncoupled
The mechanisms that underlie cell identity remain poorly understood. A study now dissects the transcriptional trajectories...
Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition
Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition
While acetylated, RNA-binding-deficient TDP-43 reversibly phase separates within nuclei into complex droplets (anisosomes)...
Comparative roadmaps of reprogramming and oncogenic transformation identify Bcl11b and Atoh8 as broad regulators of cellular plasticity
Comparative roadmaps of reprogramming and oncogenic transformation identify Bcl11b and Atoh8 as broad regulators of cellular plasticity
Coordinated changes of cellular plasticity and identity are critical for pluripotent reprogramming and oncogenic transform...
Publisher Correction: Cargo-specific recruitment in clathrin- and dynamin-independent endocytosis
Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, FinlandPaulina Moreno-Layseca, Niklas Z. J...
Mammalian genome innovation through transposon domestication
Mammalian genome innovation through transposon domestication
Since the discovery of transposons, their sheer abundance in host genomes has puzzled many. While historically viewed as l...
Roles for H3K9me3 in human embryos
Share this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a sh...
Vitamin E boosts immunotherapy
Share this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a sh...
Author Correction: Polycomb CBX7 has a unifying role in cellular lifespan
Author Correction: Polycomb CBX7 has a unifying role in cellular lifespan
Author notesJesús GilPresent address: Molecular Oncology Laboratory, Cancer Research UK, London Research Institute, 44 Lin...
Navigating ferroptosis via an NADPH sensor
Navigating ferroptosis via an NADPH sensor
NADPH levels serve as a biomarker of sensitivity to ferroptosis, but the regulators that detect cellular NADPH levels and ...
The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosis
The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosis
Ferroptosis is a unique form of cell death caused by excessive iron-dependent lipid peroxidation. The level of the anaboli...
A complex epigenome-splicing crosstalk governs epithelial-to-mesenchymal transition in metastasis and brain development
A complex epigenome-splicing crosstalk governs epithelial-to-mesenchymal transition in metastasis and brain development
Epithelial-to-mesenchymal transition (EMT) renders epithelial cells migratory properties. While epigenetic and splicing ch...
Untangling the web of intratumour heterogeneity
Untangling the web of intratumour heterogeneity
Intratumour heterogeneity (ITH) is a hallmark of cancer that drives tumour evolution and disease progression. Technologica...
Localization-dictated function for METTL3
Localization-dictated function for METTL3
Aberrant subcellular localization of proteins contributes to the pathogenesis of cancer. A study now reports that the mis-...
Nucleotide imbalance decouples cell growth from cell proliferation
Nucleotide imbalance decouples cell growth from cell proliferation
Nucleotide metabolism supports RNA synthesis and DNA replication to enable cell growth and division. Nucleotide depletion ...
METTL3 preferentially enhances non-m6A translation of epigenetic factors and promotes tumourigenesis
METTL3 preferentially enhances non-m6A translation of epigenetic factors and promotes tumourigenesis
METTL3 encodes the predominant catalytic enzyme to promote m6A methylation in nucleus. Recently, accumulating evidence has...
Mesoderm-derived PDGFRA+ cells regulate the emergence of hematopoietic stem cells in the dorsal aorta
Mesoderm-derived PDGFRA+ cells regulate the emergence of hematopoietic stem cells in the dorsal aorta
Mouse haematopoietic stem cells (HSCs) first emerge at embryonic day 10.5 (E10.5), on the ventral surface of the dorsal ao...