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Different states of stemness of glioblastoma stem cells sustain glioblastoma subtypes indicating novel clinical biomarkers and high-efficacy customized therapies
Different states of stemness of glioblastoma stem cells sustain glioblastoma subtypes indicating novel clinical biomarkers and high-efficacy customized therapies
Glioblastoma (GBM) is the most malignant among gliomas with an inevitable lethal outcome. The elucidation of the physiolog...
Correction: Long non-coding RNA NCK1-AS1 promotes the tumorigenesis of glioma through sponging microRNA-138-2-3p and activating the TRIM24/Wnt/β-catenin axis
Correction: Long non-coding RNA NCK1-AS1 promotes the tumorigenesis of glioma through sponging microRNA-138-2-3p and activating the TRIM24/Wnt/β-catenin axis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Phosphoflow cytometry to assess cytokine signaling pathways in peripheral immune cells: potential for inferring immune cell function and treatment response in patients with solid tumors
Phosphoflow cytometry to assess cytokine signaling pathways in peripheral immune cells: potential for inferring immune cell function and treatment response in patients with solid tumors
Tumor biopsy is often not available or difficult to obtain in patients with solid tumors. Investigation of the peripheral ...
Functional polarization of tumor-associated macrophages dictated by metabolic reprogramming
Functional polarization of tumor-associated macrophages dictated by metabolic reprogramming
Macrophages are highly plastic in different tissues and can differentiate into functional subpopulations under different s...
LncRNA CCAT1 facilitates the progression of gastric cancer via PTBP1-mediated glycolysis enhancement
LncRNA CCAT1 facilitates the progression of gastric cancer via PTBP1-mediated glycolysis enhancement
Gastric cancer (GC) is one of the most prevalent malignant tumors of the digestive system. As a hallmark of cancer, energy...
Correction: Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway
Correction: Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Correction: MKRN1 promotes colorectal cancer metastasis by activating the TGF-β signalling pathway through SNIP1 protein degradation
Correction: MKRN1 promotes colorectal cancer metastasis by activating the TGF-β signalling pathway through SNIP1 protein degradation
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Circ-RAPGEF5 promotes intrahepatic cholangiocarcinoma progression by stabilizing SAE1 to facilitate SUMOylation
Circ-RAPGEF5 promotes intrahepatic cholangiocarcinoma progression by stabilizing SAE1 to facilitate SUMOylation
Intrahepatic cholangiocarcinoma (ICC) is an aggressive malignancy with a poor prognosis. The underlying functions and mech...
Combination of RUNX1 inhibitor and gemcitabine mitigates chemo‐resistance in pancreatic ductal adenocarcinoma by modulating BiP/PERK/eIF2α-axis-mediated endoplasmic reticulum stress
Combination of RUNX1 inhibitor and gemcitabine mitigates chemo‐resistance in pancreatic ductal adenocarcinoma by modulating BiP/PERK/eIF2α-axis-mediated endoplasmic reticulum stress
Gemcitabine (GEM)-based chemotherapy is the first-line option for pancreatic ductal adenocarcinoma (PDAC). However, the de...
Impact of chemotherapeutic agents on liver microenvironment: oxaliplatin create a pro-metastatic landscape
Impact of chemotherapeutic agents on liver microenvironment: oxaliplatin create a pro-metastatic landscape
Chemotherapeutic agents are used to control tumor proliferation. However, their influence in the pre-metastatic niche of t...
Fusobacterium nucleatum-triggered neutrophil extracellular traps facilitate colorectal carcinoma progression
Fusobacterium nucleatum-triggered neutrophil extracellular traps facilitate colorectal carcinoma progression
Fusobacterium nucleatum (Fn) acts as a procarcinogenic bacterium in colorectal carcinoma (CRC) by regulating the inflammat...
Electrolyte imbalance causes suppression of NK and T cell effector function in malignant ascites
Electrolyte imbalance causes suppression of NK and T cell effector function in malignant ascites
Malignant ascites commonly occurs in advanced or recurrent stages of epithelial ovarian cancer during peritoneal carcinoma...
SENP5 promotes homologous recombination-mediated DNA damage repair in colorectal cancer cells through H2AZ deSUMOylation
SENP5 promotes homologous recombination-mediated DNA damage repair in colorectal cancer cells through H2AZ deSUMOylation
Neoadjuvant radiotherapy has been used as the standard treatment of colorectal cancer (CRC). However, radiotherapy resista...
Correction: Over-expression of oncigenic pesudogene DUXAP10 promotes cell proliferation and invasion by regulating LATS1 and β-catenin in gastric cancer
Correction: Over-expression of oncigenic pesudogene DUXAP10 promotes cell proliferation and invasion by regulating LATS1 and β-catenin in gastric cancer
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Deubiquitylase YOD1 regulates CDK1 stability and drives triple-negative breast cancer tumorigenesis
Deubiquitylase YOD1 regulates CDK1 stability and drives triple-negative breast cancer tumorigenesis
Accumulating evidence has demonstrated that aberrant expression of deubiquitinating enzymes is associated with the initiat...
ERCC6L facilitates the onset of mammary neoplasia and promotes the high malignance of breast cancer by accelerating the cell cycle
ERCC6L facilitates the onset of mammary neoplasia and promotes the high malignance of breast cancer by accelerating the cell cycle
Breast cancer (BC) is the leading cause of morbidity and the second leading cause of death among female malignant tumors. ...
SEC23A confers ER stress resistance in gastric cancer by forming the ER stress-SEC23A-autophagy negative feedback loop
SEC23A confers ER stress resistance in gastric cancer by forming the ER stress-SEC23A-autophagy negative feedback loop
Sec23 homolog A (SEC23A), a core component of coat protein complex II (COPII), has been reported to be involved i...
A patient-derived organoid-based study identified an ASO targeting SNORD14E for endometrial cancer through reducing aberrant FOXM1 Expression and β-catenin nuclear accumulation
A patient-derived organoid-based study identified an ASO targeting SNORD14E for endometrial cancer through reducing aberrant FOXM1 Expression and β-catenin nuclear accumulation
Most of the endometrial cancer (EC) patients are diagnosis in early stage with a good prognosis while the patients with lo...
RNA binding protein IGF2BP1 synergizes with ETV6-RUNX1 to drive oncogenic signaling in B-cell Acute Lymphoblastic Leukemia
RNA binding protein IGF2BP1 synergizes with ETV6-RUNX1 to drive oncogenic signaling in B-cell Acute Lymphoblastic Leukemia
Acute lymphoblastic leukemia (ALL) is the most common pediatric hematological malignancy, with ETV6::RUNX1 being the most ...
Targeting ubiquitin specific proteases (USPs) in cancer immunotherapy: from basic research to preclinical application
Targeting ubiquitin specific proteases (USPs) in cancer immunotherapy: from basic research to preclinical application
Tumors have evolved in various mechanisms to evade the immune system, hindering the antitumor immune response and facilita...
Retraction Note: NF-κB maintains the stemness of colon cancer cells by downregulating miR-195- 5p/497–5p and upregulating MCM2
Retraction Note: NF-κB maintains the stemness of colon cancer cells by downregulating miR-195- 5p/497–5p and upregulating MCM2
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
FAT4 overexpression promotes antitumor immunity by regulating the β-catenin/STT3/PD-L1 axis in cervical cancer
FAT4 overexpression promotes antitumor immunity by regulating the β-catenin/STT3/PD-L1 axis in cervical cancer
FAT4 (FAT Atypical Cadherin 4) is a member of the cadherin-associated protein family, which has been shown to function as ...
FBXW7 in breast cancer: mechanism of action and therapeutic potential
FBXW7 in breast cancer: mechanism of action and therapeutic potential
Breast cancer is one of the frequent tumors that seriously endanger the physical and mental well-being in women. F-box and...
Retinoic acid and proteotoxic stress induce AML cell death overcoming stromal cell protection
Retinoic acid and proteotoxic stress induce AML cell death overcoming stromal cell protection
Acute myeloid leukemia (AML) patients bearing the ITD mutation in the tyrosine kinase receptor FLT3 (FLT3-ITD) present a p...
Exosome nanovesicles as potential biomarkers and immune checkpoint signaling modulators in lung cancer microenvironment: recent advances and emerging concepts
Exosome nanovesicles as potential biomarkers and immune checkpoint signaling modulators in lung cancer microenvironment: recent advances and emerging concepts
Lung cancer remains the leading cause of cancer-related deaths globally, and the survival rate remains low despite advance...
Correction: Glycogen synthase 1 targeting reveals a metabolic vulnerability in triple-negative breast cancer
Correction: Glycogen synthase 1 targeting reveals a metabolic vulnerability in triple-negative breast cancer
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
MKRN1 promotes colorectal cancer metastasis by activating the TGF-β signalling pathway through SNIP1 protein degradation
MKRN1 promotes colorectal cancer metastasis by activating the TGF-β signalling pathway through SNIP1 protein degradation
The Makorin ring finger protein 1 (MKRN1) gene, also called RNF61, is located on the long arm of chromosome 7 and is a mem...
The circadian clock circuitry modulates leukemia initiating cell activity in T-cell acute lymphoblastic leukemia
The circadian clock circuitry modulates leukemia initiating cell activity in T-cell acute lymphoblastic leukemia
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy, characterized by restricted cellula...
m6A eraser FTO impairs gemcitabine resistance in pancreatic cancer through influencing NEDD4 mRNA stability by regulating the PTEN/PI3K/AKT pathway
m6A eraser FTO impairs gemcitabine resistance in pancreatic cancer through influencing NEDD4 mRNA stability by regulating the PTEN/PI3K/AKT pathway
Gemcitabine resistance has brought great challenges to the treatment of pancreatic cancer. The N6-methyladenosine (m6A) mu...
Dose-related immunomodulatory effects of recombinant TRAIL in the tumor immune microenvironment
Dose-related immunomodulatory effects of recombinant TRAIL in the tumor immune microenvironment
In addition to specifically inducing tumor cell apoptosis, recombinant tumor necrosis factor (TNF)-related apoptosis-induc...
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