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Gasdermin B over-expression modulates HER2-targeted therapy resistance by inducing protective autophagy through Rab7 activation
Gasdermin B over-expression modulates HER2-targeted therapy resistance by inducing protective autophagy through Rab7 activation
Gasdermin B (GSDMB) over-expression promotes poor prognosis and aggressive behavior in HER2 breast cancer by increasing re...
AADAC protects colorectal cancer liver colonization from ferroptosis through SLC7A11-dependent inhibition of lipid peroxidation
AADAC protects colorectal cancer liver colonization from ferroptosis through SLC7A11-dependent inhibition of lipid peroxidation
Oxidative stress is a highly active metabolic process in the liver, that poses great threats to disseminated tumor cells d...
The roles of small extracellular vesicles in cancer and immune regulation and translational potential in cancer therapy
The roles of small extracellular vesicles in cancer and immune regulation and translational potential in cancer therapy
Extracellular vesicles (EVs) facilitate the extracellular transfer of proteins, lipids, and nucleic acids and mediate inte...
The immune microenvironment of HPV-positive and HPV-negative oropharyngeal squamous cell carcinoma: a multiparametric quantitative and spatial analysis unveils a rationale to target treatment-naïve tumors with immune checkpoint inhibitors
The immune microenvironment of HPV-positive and HPV-negative oropharyngeal squamous cell carcinoma: a multiparametric quantitative and spatial analysis unveils a rationale to target treatment-naïve tumors with immune checkpoint inhibitors
Immune checkpoint inhibitors (ICI) are approved for treatment of recurrent or metastatic oropharyngeal head and neck squam...
Retraction Note: SETDB1 promotes glioblastoma growth via CSF-1-dependent macrophage recruitment by activating the AKT/mTOR signaling pathway
Retraction Note: SETDB1 promotes glioblastoma growth via CSF-1-dependent macrophage recruitment by activating the AKT/mTOR signaling pathway
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-020-0173...
CircPAK1 promotes the progression of hepatocellular carcinoma via modulation of YAP nucleus localization by interacting with 14-3-3ζ
CircPAK1 promotes the progression of hepatocellular carcinoma via modulation of YAP nucleus localization by interacting with 14-3-3ζ
Circular RNA (circRNA), a new class of non-coding RNA, has obvious correlations with the occurrence and development of man...
Preclinical assessment of synergistic efficacy of MELK and CDK inhibitors in adrenocortical cancer
Preclinical assessment of synergistic efficacy of MELK and CDK inhibitors in adrenocortical cancer
Adrenocortical cancer (ACC) is a rare and aggressive cancer with dismal 5-year survival due to a lack of effective treatme...
Wild-type IDH1 inhibition enhances chemotherapy response in melanoma
Wild-type IDH1 inhibition enhances chemotherapy response in melanoma
Alternative treatment strategies in melanoma beyond immunotherapy and mutation-targeted therapy are urgently needed. Wild-...
The extracellular matrix alteration, implication in modulation of drug resistance mechanism: friends or foes?
The extracellular matrix alteration, implication in modulation of drug resistance mechanism: friends or foes?
The extracellular matrix (ECM) is an important component of the tumor microenvironment (TME), having several important rol...
Non-coding RNAs and epithelial mesenchymal transition in cancer: molecular mechanisms and clinical implications
Non-coding RNAs and epithelial mesenchymal transition in cancer: molecular mechanisms and clinical implications
Epithelial-mesenchymal transition (EMT) is a fundamental process for embryonic development during which epithelial cells a...
Harnessing preclinical models for the interrogation of ovarian cancer
Harnessing preclinical models for the interrogation of ovarian cancer
Ovarian cancer (OC) is a heterogeneous malignancy with various etiology, histopathology, and biological feature. Despite a...
Long noncoding RNA LINC01132 enhances immunosuppression and therapy resistance via NRF1/DPP4 axis in hepatocellular carcinoma
Long noncoding RNA LINC01132 enhances immunosuppression and therapy resistance via NRF1/DPP4 axis in hepatocellular carcinoma
Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression and play fundamental roles in various...
Elesclomol: a copper ionophore targeting mitochondrial metabolism for cancer therapy
Elesclomol: a copper ionophore targeting mitochondrial metabolism for cancer therapy
Elesclomol is an anticancer drug that targets mitochondrial metabolism. In the past, elesclomol was recognized as an induc...
Combined alteration of lamin and nuclear morphology influences the localization of the tumor-associated factor AKTIP
Combined alteration of lamin and nuclear morphology influences the localization of the tumor-associated factor AKTIP
Lamins, key nuclear lamina components, have been proposed as candidate risk biomarkers in different types of cancer but th...
Retraction Note: MicroRNA-1468 promotes tumor progression by activating PPAR-γ-mediated AKT signaling in human hepatocellular carcinoma
Retraction Note: MicroRNA-1468 promotes tumor progression by activating PPAR-γ-mediated AKT signaling in human hepatocellular carcinoma
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-018-0717-3
RETSAT associates with DDX39B to promote fork restarting and resistance to gemcitabine based chemotherapy in pancreatic ductal adenocarcinoma
RETSAT associates with DDX39B to promote fork restarting and resistance to gemcitabine based chemotherapy in pancreatic ductal adenocarcinoma
Severe hypoxia is a prominent character of pancreatic ductal adenocarcinoma (PDAC) microenvironment. In the process of gem...
Novel tri-specific tribodies induce strong T cell activation and anti-tumor effects in vitro and in vivo
Novel tri-specific tribodies induce strong T cell activation and anti-tumor effects in vitro and in vivo
Immunotherapy based on Bi-specific T Cell Engagers (TCE) represents one of the most attractive strategy to treat cancers r...
The role of DNA damage repair (DDR) system in response to immune checkpoint inhibitor (ICI) therapy
The role of DNA damage repair (DDR) system in response to immune checkpoint inhibitor (ICI) therapy
As our understanding of the mechanisms of cancer treatment has increased, a growing number of studies demonstrate pathways...
Retraction Note: Isovitexin reduces carcinogenicity and stemness in hepatic carcinoma stem-like cells by modulating MnSOD and FoxM1
Retraction Note: Isovitexin reduces carcinogenicity and stemness in hepatic carcinoma stem-like cells by modulating MnSOD and FoxM1
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-019-1244...
The neuronal protein Neuroligin 1 promotes colorectal cancer progression by modulating the APC/β-catenin pathway
The neuronal protein Neuroligin 1 promotes colorectal cancer progression by modulating the APC/β-catenin pathway
Colorectal cancer (CRC) remains largely incurable when diagnosed at the metastatic stage. Despite some advances in precisi...
Correction: LncRNA-mediated DNA methylation: an emerging mechanism in cancer and beyond
Correction: LncRNA-mediated DNA methylation: an emerging mechanism in cancer and beyond
An amendment to this paper has been published and can be accessed via the original article.
Heterogeneity of triple negative breast cancer: Current advances in subtyping and treatment implications
Heterogeneity of triple negative breast cancer: Current advances in subtyping and treatment implications
As the field of translational ‘omics has progressed, refined classifiers at both genomic and proteomic levels have e...
APE1 redox function is required for activation of Yes-associated protein 1 under reflux conditions in Barrett’s-associated esophageal adenocarcinomas
APE1 redox function is required for activation of Yes-associated protein 1 under reflux conditions in Barrett’s-associated esophageal adenocarcinomas
Esophageal adenocarcinoma (EAC) is characterized by poor prognosis and low survival rate. Chronic gastroesophageal reflux ...
YTHDC1 is downregulated by the YY1/HDAC2 complex and controls the sensitivity of ccRCC to sunitinib by targeting the ANXA1-MAPK pathway
YTHDC1 is downregulated by the YY1/HDAC2 complex and controls the sensitivity of ccRCC to sunitinib by targeting the ANXA1-MAPK pathway
Tyrosine kinase inhibitors (TKIs) such as sunitinib are multitarget antiangiogenic agents in clear cell renal cell carcino...
Tumor associated macrophages-derived exosomes facilitate hepatocellular carcinoma malignance by transferring lncMMPA to tumor cells and activating glycolysis pathway
Tumor associated macrophages-derived exosomes facilitate hepatocellular carcinoma malignance by transferring lncMMPA to tumor cells and activating glycolysis pathway
Tumor-associated macrophages (TAMs), which form a large part of the tumor microenvironment, are normally regulated by meta...
CircARID1A binds to IGF2BP3 in gastric cancer and promotes cancer proliferation by forming a circARID1A-IGF2BP3-SLC7A5 RNA–protein ternary complex
CircARID1A binds to IGF2BP3 in gastric cancer and promotes cancer proliferation by forming a circARID1A-IGF2BP3-SLC7A5 RNA–protein ternary complex
Gastric cancer (GC) is one of the most common malignant tumors in China. Circular RNAs (circRNAs) are novel non-coding RNA...
Transfection with Plasmid-Encoding lncRNA-SLERCC nanoparticle-mediated delivery suppressed tumor progression in renal cell carcinoma
Transfection with Plasmid-Encoding lncRNA-SLERCC nanoparticle-mediated delivery suppressed tumor progression in renal cell carcinoma
The accumulating evidence confirms that long non-coding RNAs (lncRNAs) play a critical regulatory role in the progression ...
Rational drug combination design in patient-derived avatars reveals effective inhibition of hepatocellular carcinoma with proteasome and CDK inhibitors
Rational drug combination design in patient-derived avatars reveals effective inhibition of hepatocellular carcinoma with proteasome and CDK inhibitors
Hepatocellular carcinoma (HCC) remains difficult to treat due to limited effective treatment options. While the proteasome...
Correction: MicroRNA-30a-5pme: a novel diagnostic and prognostic biomarker for clear cell renal cell carcinoma in tissue and urine samples
Correction: MicroRNA-30a-5pme: a novel diagnostic and prognostic biomarker for clear cell renal cell carcinoma in tissue and urine samples
Gonçalo Outeiro-Pinho and Daniela Barros-Silva are joint first authors.Cancer Biology and Epigenetics Group, IPO Porto Res...
The diverse functions of FAT1 in cancer progression: good, bad, or ugly?
The diverse functions of FAT1 in cancer progression: good, bad, or ugly?
FAT atypical cadherin 1 (FAT1) is among the most frequently mutated genes in many types of cancer. Its highest mutation ra...
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