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Preclinical assessment of synergistic efficacy of MELK and CDK inhibitors in adrenocortical cancer
Preclinical assessment of synergistic efficacy of MELK and CDK inhibitors in adrenocortical cancer
Adrenocortical cancer (ACC) is a rare and aggressive cancer with dismal 5-year survival due to a lack of effective treatme...
Wild-type IDH1 inhibition enhances chemotherapy response in melanoma
Wild-type IDH1 inhibition enhances chemotherapy response in melanoma
Alternative treatment strategies in melanoma beyond immunotherapy and mutation-targeted therapy are urgently needed. Wild-...
The extracellular matrix alteration, implication in modulation of drug resistance mechanism: friends or foes?
The extracellular matrix alteration, implication in modulation of drug resistance mechanism: friends or foes?
The extracellular matrix (ECM) is an important component of the tumor microenvironment (TME), having several important rol...
Harnessing preclinical models for the interrogation of ovarian cancer
Harnessing preclinical models for the interrogation of ovarian cancer
Ovarian cancer (OC) is a heterogeneous malignancy with various etiology, histopathology, and biological feature. Despite a...
Elesclomol: a copper ionophore targeting mitochondrial metabolism for cancer therapy
Elesclomol: a copper ionophore targeting mitochondrial metabolism for cancer therapy
Elesclomol is an anticancer drug that targets mitochondrial metabolism. In the past, elesclomol was recognized as an induc...
Novel tri-specific tribodies induce strong T cell activation and anti-tumor effects in vitro and in vivo
Novel tri-specific tribodies induce strong T cell activation and anti-tumor effects in vitro and in vivo
Immunotherapy based on Bi-specific T Cell Engagers (TCE) represents one of the most attractive strategy to treat cancers r...
The role of DNA damage repair (DDR) system in response to immune checkpoint inhibitor (ICI) therapy
The role of DNA damage repair (DDR) system in response to immune checkpoint inhibitor (ICI) therapy
As our understanding of the mechanisms of cancer treatment has increased, a growing number of studies demonstrate pathways...
Heterogeneity of triple negative breast cancer: Current advances in subtyping and treatment implications
Heterogeneity of triple negative breast cancer: Current advances in subtyping and treatment implications
As the field of translational ‘omics has progressed, refined classifiers at both genomic and proteomic levels have e...
The diverse functions of FAT1 in cancer progression: good, bad, or ugly?
The diverse functions of FAT1 in cancer progression: good, bad, or ugly?
FAT atypical cadherin 1 (FAT1) is among the most frequently mutated genes in many types of cancer. Its highest mutation ra...