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HERC5 downregulation in non-small cell lung cancer is associated with altered energy metabolism and metastasis
HERC5 downregulation in non-small cell lung cancer is associated with altered energy metabolism and metastasis
Metastasis is the leading cause of cancer-related death in non-small cell lung cancer (NSCLC) patients. We previously show...
A phenotypic screening approach to target p60AmotL2-expressing invasive cancer cells
A phenotypic screening approach to target p60AmotL2-expressing invasive cancer cells
Tumor cells have the ability to invade and form small clusters that protrude into adjacent tissues, a phenomenon that is f...
Targeting FTO induces colorectal cancer ferroptotic cell death by decreasing SLC7A11/GPX4 expression
Targeting FTO induces colorectal cancer ferroptotic cell death by decreasing SLC7A11/GPX4 expression
Ferroptosis is a newly identified iron-dependent form of death that is becoming increasingly recognized as a promising ave...
HSPA4 upregulation induces immune evasion via ALKBH5/CD58 axis in gastric cancer
HSPA4 upregulation induces immune evasion via ALKBH5/CD58 axis in gastric cancer
Gastric cancer (GC) is one of the leading causes of cancer-related death worldwide. Recently, targeted therapies including...
RBM10 C761Y mutation induced oncogenic ASPM isoforms and regulated β-catenin signaling in cholangiocarcinoma
RBM10 C761Y mutation induced oncogenic ASPM isoforms and regulated β-catenin signaling in cholangiocarcinoma
Cholangiocarcinoma (CCA) comprises a heterogeneous group of biliary tract cancer. Our previous CCA mutation pattern study ...
Transcriptional regulation of cancer stem cell: regulatory factors elucidation and cancer treatment strategies
Transcriptional regulation of cancer stem cell: regulatory factors elucidation and cancer treatment strategies
Cancer stem cells (CSCs) were first discovered in the 1990s, revealing the mysteries of cancer origin, migration, recurren...
Mesothelin promotes brain metastasis of non-small cell lung cancer by activating MET
Mesothelin promotes brain metastasis of non-small cell lung cancer by activating MET
Brain metastasis (BM) is common among cases of advanced non-small cell lung cancer (NSCLC) and is the leading cause of dea...
Oncolytic adenovirus encoding apolipoprotein A1 suppresses metastasis of triple-negative breast cancer in mice
Oncolytic adenovirus encoding apolipoprotein A1 suppresses metastasis of triple-negative breast cancer in mice
Dysregulation of cholesterol metabolism is associated with the metastasis of triple-negative breast cancer (TNBC). Apolipo...
Liquid biopsy techniques and lung cancer: diagnosis, monitoring and evaluation
Liquid biopsy techniques and lung cancer: diagnosis, monitoring and evaluation
Lung cancer stands as the most prevalent form of cancer globally, posing a significant threat to human well-being. Due to ...
PELI1: key players in the oncogenic characteristics of pancreatic Cancer
PELI1: key players in the oncogenic characteristics of pancreatic Cancer
Pancreatic cancer (PC) is a highly malignant gastrointestinal tumor, which is characterized by difficulties in early diagn...
Ropivacaine as a novel AKT1 specific inhibitor regulates the stemness of breast cancer
Ropivacaine as a novel AKT1 specific inhibitor regulates the stemness of breast cancer
Ropivacaine, a local anesthetic, exhibits anti-tumor effects in various cancer types. However, its specific functions and ...
Anaplastic thyroid cancer spheroids as preclinical models to test therapeutics
Anaplastic thyroid cancer spheroids as preclinical models to test therapeutics
Anaplastic thyroid cancer (ATC) is the most aggressive thyroid cancer. Despite advances in tissue culture techniques, a ro...
The localization, origin, and impact of platelets in the tumor microenvironment are tumor type-dependent
The localization, origin, and impact of platelets in the tumor microenvironment are tumor type-dependent
How platelets interact with and influence the tumor microenvironment (TME) remains poorly characterized. We compared the p...