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Functional polarization of tumor-associated macrophages dictated by metabolic reprogramming
Functional polarization of tumor-associated macrophages dictated by metabolic reprogramming
Macrophages are highly plastic in different tissues and can differentiate into functional subpopulations under different s...
LncRNA CCAT1 facilitates the progression of gastric cancer via PTBP1-mediated glycolysis enhancement
LncRNA CCAT1 facilitates the progression of gastric cancer via PTBP1-mediated glycolysis enhancement
Gastric cancer (GC) is one of the most prevalent malignant tumors of the digestive system. As a hallmark of cancer, energy...
Impact of chemotherapeutic agents on liver microenvironment: oxaliplatin create a pro-metastatic landscape
Impact of chemotherapeutic agents on liver microenvironment: oxaliplatin create a pro-metastatic landscape
Chemotherapeutic agents are used to control tumor proliferation. However, their influence in the pre-metastatic niche of t...
Fusobacterium nucleatum-triggered neutrophil extracellular traps facilitate colorectal carcinoma progression
Fusobacterium nucleatum-triggered neutrophil extracellular traps facilitate colorectal carcinoma progression
Fusobacterium nucleatum (Fn) acts as a procarcinogenic bacterium in colorectal carcinoma (CRC) by regulating the inflammat...
Electrolyte imbalance causes suppression of NK and T cell effector function in malignant ascites
Electrolyte imbalance causes suppression of NK and T cell effector function in malignant ascites
Malignant ascites commonly occurs in advanced or recurrent stages of epithelial ovarian cancer during peritoneal carcinoma...
Deubiquitylase YOD1 regulates CDK1 stability and drives triple-negative breast cancer tumorigenesis
Deubiquitylase YOD1 regulates CDK1 stability and drives triple-negative breast cancer tumorigenesis
Accumulating evidence has demonstrated that aberrant expression of deubiquitinating enzymes is associated with the initiat...
FBXW7 in breast cancer: mechanism of action and therapeutic potential
FBXW7 in breast cancer: mechanism of action and therapeutic potential
Breast cancer is one of the frequent tumors that seriously endanger the physical and mental well-being in women. F-box and...
Retinoic acid and proteotoxic stress induce AML cell death overcoming stromal cell protection
Retinoic acid and proteotoxic stress induce AML cell death overcoming stromal cell protection
Acute myeloid leukemia (AML) patients bearing the ITD mutation in the tyrosine kinase receptor FLT3 (FLT3-ITD) present a p...
Dose-related immunomodulatory effects of recombinant TRAIL in the tumor immune microenvironment
Dose-related immunomodulatory effects of recombinant TRAIL in the tumor immune microenvironment
In addition to specifically inducing tumor cell apoptosis, recombinant tumor necrosis factor (TNF)-related apoptosis-induc...