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Growth hormone-releasing hormone and its analogues in health and disease
Growth hormone-releasing hormone and its analogues in health and disease
Growth hormone-releasing hormone (GHRH) and its ability to stimulate the production and release of growth hormone from the...
Autologous stem-cell derived islets — the ultimate frontier in diabetes mellitus?
Autologous stem-cell derived islets — the ultimate frontier in diabetes mellitus?
A patient with longstanding type 1 diabetes mellitus has achieved insulin independence for at least 1 ye...
Macrophages support pancreatic development
Macrophages support pancreatic development
Engineering pancreatic tissue transplants to treat diabetes mellitus will require knowledge of how different cell types re...
Highlights from the Joint Irish–UK Endocrine Meeting 2024
This October, the first joint meeting between the Irish Endocrine Society (IES) and the British Society for Endocrinology ...
IL-17 has a role in whole-body homeostasis
IL-17 has a role in whole-body homeostasis
The immune system is known to have a circadian rhythm; however, how circadian rhythms might affect immune homeostasis and ...
Intricacies and obscurities of non-shivering thermogenesis
Mammalian cellular machinery has evolved to function best at ~37 °C, making maintenance of core body temperature (at ~37 °...
Our future, we decide: five ways to reform the scientific publication process
Our future, we decide: five ways to reform the scientific publication process
Although science is becoming ever more complex, interdisciplinary and open, the scientific publication process has largely...
Looking back at the TEDDY study: lessons and future directions
Looking back at the TEDDY study: lessons and future directions
The goal of the TEDDY (The Environmental Determinants of Diabetes in the Young) study is to elucidate factors lea...
Modelling human liver disease: from steatotic liver disease to MASH-HCC
Modelling human liver disease: from steatotic liver disease to MASH-HCC
Having more refined mouse models of metabolic dysfunction-associated steatotic liver disease (MASLD; also known as nonalco...
Publisher Correction: Current understanding of the molecular and cellular pathology of diabetic retinopathy
Publisher Correction: Current understanding of the molecular and cellular pathology of diabetic retinopathy
Authors and AffiliationsDepartment of Ophthalmology and Visual Sciences, Department of Molecular and Integrative Physiolog...
Limiting the use and misuse of liothyronine in hypothyroidism
Liothyronine treatment for some patients with hypothyroidism has preoccupied academics, clinicians and patients for decade...
The epidemiology of type 1 diabetes mellitus in older adults
The epidemiology of type 1 diabetes mellitus in older adults
Although type 1 diabetes mellitus (T1DM) is traditionally viewed as a youth-onset disorder, the number of older adults bei...
Inflammation and resolution in obesity
Inflammation and resolution in obesity
Inflammation is an essential physiological defence mechanism, but prolonged or excessive inflammation can cause disease. I...
Metformin in gestational diabetes: physiological actions and clinical applications
Metformin in gestational diabetes: physiological actions and clinical applications
Metformin is an effective oral hypoglycaemic agent used in the treatment of type 2 diabetes mellitus; however, its use in ...
The complex effects of dietary restriction on longevity and health
The complex effects of dietary restriction on longevity and health
Calorie restriction is known to extend lifespan in a wide range of species; however, the effects are variable and findings...
IGF2-produced microRNA restricts growth via suppression of IGF1
IGF2-produced microRNA restricts growth via suppression of IGF1
Insulin-like growth factor 1 (IGF1) is a key protein that contributes to control of an organism’s size after birth and dur...
Signals from the dorsal motor nucleus of the vagus promote jejunal fat absorption
Signals from the dorsal motor nucleus of the vagus promote jejunal fat absorption
Efferent nerves from the dorsal motor nucleus of the vagus (DMV) connect to the gastrointestinal system and are thought to...
Skeletal stem and progenitor cells in bone physiology, ageing and disease
Skeletal stem and progenitor cells in bone physiology, ageing and disease
Skeletal stem cells (SSCs) and related progenitors with osteogenic potential, collectively termed skeletal stem and/or pro...
Liver-specific actions of GH and IGF1 that protect against MASLD
Liver-specific actions of GH and IGF1 that protect against MASLD
Metabolic dysfunction-associated steatotic liver disease (MASLD; also known as nonalcoholic fatty liver disease) is a chro...
Control of tuberal hypothalamic development and its implications in metabolic disorders
Control of tuberal hypothalamic development and its implications in metabolic disorders
The tuberal hypothalamus regulates a range of crucial physiological processes, including energy homeostasis and metabolism...
The multifactorial effect of obesity on the effectiveness and outcomes of cancer therapies
The multifactorial effect of obesity on the effectiveness and outcomes of cancer therapies
Epidemiology studies have demonstrated a clear association between obesity and the development of several distinct maligna...
Early life factors that affect obesity and the need for complex solutions
Early life factors that affect obesity and the need for complex solutions
The prevalence of obesity increases with age but is apparent even in early life. Early childhood is a critical period for ...
Brown adipose tissue fights the battle against leukaemia
Brown adipose tissue fights the battle against leukaemia
Brown adipocytes are increasingly recognized as a promising therapeutic target for metabolic disorders. Research published...
The glymphatic system as a nexus between obesity and neurological diseases
The glymphatic system as a nexus between obesity and neurological diseases
Exploring the glymphatic system across neurological and metabolic diseases might help us to better define the link between...
Skeletal muscle loss and sarcopenia in obesity pharmacotherapy
Pharmacological therapies with incretin-based ‘multi-agonists’ are rapidly advancing the therapeutic landscape...
Female-specific inflammatory signalling exacerbates central nervous system autoimmunity in obesity
Female-specific inflammatory signalling exacerbates central nervous system autoimmunity in obesity
Multiple sclerosis (MS) targets the myelin sheath of central nervous system (CNS) neurons. MS is initiated by autoreactive...
Effects of diet on atherosclerotic plaque development
Effects of diet on atherosclerotic plaque development
Atherosclerosis-related cardiovascular diseases are a major cause of death globally, and are expected to increase in preva...
The role of DNA damage in diabetic complications
The role of DNA damage in diabetic complications
Mechanistic and clinical data indicate that DNA damage contributes to the pathogenesis and progression of diabetic complic...
Harnessing cellular therapeutics for type 1 diabetes mellitus: progress, challenges, and the road ahead
Harnessing cellular therapeutics for type 1 diabetes mellitus: progress, challenges, and the road ahead
Type 1 diabetes mellitus (T1DM) is a growing global health concern that affects approximately 8.5 million individuals worl...
Neurons in the diagonal band of Broca moderate food intake
Neurons in the diagonal band of Broca moderate food intake
Identifying neurological mechanisms that regulate feeding behaviour could help to advance the treatment and prevention of ...
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