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GWAS gives insights into glucose regulation
GWAS gives insights into glucose regulation
Fasting levels of glucose and susceptibility to type 2 diabetes mellitus (T2DM) are known to have a large genetic componen...
Sex differences in cardiometabolic health
Women and men have different risk profiles for certain health conditions. For instance, differences in body composition be...
The evolving functions of the vasculature in regulating adipose tissue biology in health and obesity
The evolving functions of the vasculature in regulating adipose tissue biology in health and obesity
Adipose tissue is an endocrine organ and a crucial regulator of energy storage and systemic metabolic homeostasis. Additio...
Long-term effects of untreated leptin deficiency
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Microbial metabolism linked to insulin resistance
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Control of adipose tissue cellularity by the terminal complement cascade
Control of adipose tissue cellularity by the terminal complement cascade
Adipocytes have high levels of many components of the complement system. These components are involved in antimicrobial ac...
Inflammation-induced adrenal dysfunction
Inflammation-induced adrenal dysfunction
Acute inflammation triggers activation of the hypothalamic–pituitary–adrenal axis, but whether it could also i...
Non-invasive daily profiles of tissue adrenal steroids
Non-invasive daily profiles of tissue adrenal steroids
In a new study, an ambulatory microdialysis system combined with ultrasensitive liquid chromatography-tandem mass spectrom...
Obesity-induced and weight-loss-induced physiological factors affecting weight regain
Obesity-induced and weight-loss-induced physiological factors affecting weight regain
Weight regain after successful weight loss resulting from lifestyle interventions is a major challenge in the management o...
Length of light exposure alters energy metabolism in mice
Length of light exposure alters energy metabolism in mice
Circadian rhythms, which are influenced by the light and dark that an organism is exposed to, have important effects on ph...
Pituitary crosstalk with bone, adipose tissue and brain
Pituitary crosstalk with bone, adipose tissue and brain
Traditional textbook physiology has ascribed unitary functions to hormones from the anterior and posterior pituitary gland...
The influence of the circulatory system on tissue ageing: does the fountain of youth lie in our blood?
Tales of vampirism date back to the ancient Egyptian goddess of war and healing, Sekhmet, whose consumption of human blood...
Bile acid species shows potential for NAFLD
A pressing need exists for effective drugs to treat nonalcoholic fatty liver disease (NAFLD), which affects around a quart...
Diagnosis and management of prolactin-secreting pituitary adenomas: a Pituitary Society international Consensus Statement
Diagnosis and management of prolactin-secreting pituitary adenomas: a Pituitary Society international Consensus Statement
This Consensus Statement from an international, multidisciplinary workshop sponsored by the Pituitary Society offers evide...
Advanced neurobiological tools to interrogate metabolism
Advanced neurobiological tools to interrogate metabolism
Engineered neurobiological tools for the manipulation of cellular activity, such as chemogenetics and optogenetics, have b...
NK3R antagonists: a novel approach for menopause symptoms
Most women experience vasomotor symptoms during menopause, which considerably affect their quality of life. While vasomoto...
Microglial inflammatory signalling improves glucose tolerance
Microglial inflammatory signalling improves glucose tolerance
Previous work has demonstrated that a high-fat diet (HFD) induces hypothalamic inflammation and gliosis in rodents, and th...
Nutrient regulation of bone marrow adipose tissue: skeletal implications of weight loss
Nutrient regulation of bone marrow adipose tissue: skeletal implications of weight loss
Adipose tissue is a dynamic component of the bone marrow, regulating skeletal remodelling and secreting paracrine and endo...
Mammary ductal cells regulate adipose thermogenesis
Mammary ductal cells regulate adipose thermogenesis
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β-adrenergic receptors feel the heat against obesity
Obesity is a serious and growing socioeconomic concern that affects almost half of adults in the USA, and is an independen...
Pituitary adenoma or neuroendocrine tumour: the need for an integrated prognostic classification
Pituitary adenoma or neuroendocrine tumour: the need for an integrated prognostic classification
In the 2022 fifth edition of the WHO Classification of Endocrine Tumours and of Central Nervous System Tumours, pituitary ...
The regulation of endocrine-disrupting chemicals to minimize their impact on health
The regulation of endocrine-disrupting chemicals to minimize their impact on health
Endocrine-disrupting chemicals (EDCs) are substances generated by human industrial activities that are detrimental to huma...
Function of a common FTO variant in vivo
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An individualized approach to the management of Cushing disease
An individualized approach to the management of Cushing disease
Cushing disease caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary corticotroph adenoma leads to hypercor...
Unravelling leptin variants: advancing precision medicine in obesity
Unravelling leptin variants: advancing precision medicine in obesity
Funcke et al. shed light on the management of leptin replacement therapy in monogenic obesity by identifying two LEP varia...
Metabolic and feeding adjustments during pregnancy
Metabolic and feeding adjustments during pregnancy
Eating behaviours are determined by the integration of interoceptive and environmental inputs. During pregnancy, numerous ...
Timing of food intake affects energy expenditure
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Antioxidant liver myeloid cell population identified
Antioxidant liver myeloid cell population identified
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Uncovering the origin of oxidative damage in ischaemia–reperfusion injury in the heart
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Fetal orchestration of maternal metabolism via IGF2
Fetal orchestration of maternal metabolism via IGF2
Pregnancy is a state of cooperation and conflict between mother and offspring, which ensures that the nutrient demands of ...
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