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Protein tyrosine phosphatase 1B in metabolic diseases and drug development
Protein tyrosine phosphatase 1B in metabolic diseases and drug development
Protein tyrosine phosphatase 1B (PTP1B), a non-transmembrane phosphatase, has a major role in a variety of signal...
Tumour fibrosis in dopamine agonist-exposed prolactinomas is a diminishing concern
We applaud the Pituitary Society on the latest prolactinoma Consensus Statement (Petersenn, S. et al....
Sex differences in diabetic kidney disease explained
Sex differences in diabetic kidney disease explained
Diabetic kidney disease (DKD) is a common complication of diabetes mellitus and can lead to chronic kidney failure. Howeve...
Reply to ‘Tumour fibrosis in dopamine agonist-exposed prolactinomas is a diminishing concern’
The authors acknowledge all the other authors of Petersenn, S. et al. Diagnosis and management of prolactin-secreting pitu...
The hypothalamic–pituitary–gonadal axis and the enigma of Alzheimer disease sex differences
The hypothalamic–pituitary–gonadal axis and the enigma of Alzheimer disease sex differences
Alzheimer disease has a sex bias: women are twice as likely as men to be affected. Studies have linked elevated follicle-s...
Reply to ‘Slowly progressive insulin dependent diabetes mellitus in type 1 diabetes endotype 2’
We are grateful to Tetsuro Kobayashi and Takashi Kadowaki for their correspondence on our Review (Red...
Slowly progressive insulin-dependent diabetes mellitus in type 1 diabetes endotype 2
We have read with great interest the Review by Maria J. Redondo and Noel G. Morgan (Redondo, M.J., Mo...
Endocrine and cellular physiology and pathology of the insulin-like growth factor acid-labile subunit
Endocrine and cellular physiology and pathology of the insulin-like growth factor acid-labile subunit
The acid-labile subunit (ALS) of the insulin-like growth factor (IGF) binding protein (IGFBP) complex, encoded in humans b...
Inceptor loss in mice with obesity
Inceptor loss in mice with obesity
Inceptor (encoded by Iir) is a novel receptor that inhibits insulin receptor and insulin-like growth factor signalling. A ...
Metabolic regulation of skeletal cell fate and function
Metabolic regulation of skeletal cell fate and function
Bone development and bone remodelling during adult life are highly anabolic processes requiring an adequate supply of oxyg...
The individual response to antibiotics and diet — insights into gut microbial resilience and host metabolism
The individual response to antibiotics and diet — insights into gut microbial resilience and host metabolism
Antibiotic use disrupts microbial composition and activity in humans, but whether this disruption in turn affects host met...
Antibodies drive adipose tissue ageing
Antibodies drive adipose tissue ageing
The mechanisms underlying metabolic decline during ageing are not well understood. A new study in Cell Metabolism identifi...
Thyroid-function reference ranges in the diagnosis of thyroid dysfunction in adults
Applying a uniform reference range across all adults for serum levels of thyroid stimulating hormone and thyroid hormones ...
Controlling brown adipose tissue size through EPAC1
Controlling brown adipose tissue size through EPAC1
A new study by Reverte-Salisa and colleagues identifies a molecular mechanism through which the cAMP-mediating protein EPA...
Cryo-electron microscopy for GPCR research and drug discovery in endocrinology and metabolism
Cryo-electron microscopy for GPCR research and drug discovery in endocrinology and metabolism
G protein-coupled receptors (GPCRs) are the largest family of cell surface receptors, with many GPCRs having crucial roles...
An historical step in our understanding of hypothalamic oestrogen feedback
In 1957, Béla Flerkó and János Szentágothai implanted ovarian and liver tissue autografts into two distinct hypothalamic r...
Phase I results for AMG 133
The past few years have seen a rapid increase in the development and use of new drugs to treat obesity, many of which targ...
Endocrine disrupting chemicals are a threat to hormone health: a commentary on behalf of the ESE
The European Society of Endocrinology (ESE), representing 20,000 endocrinologists, is concerned about the effect of endocr...
Beyond the ovary: rewiring our perspective on polycystic ovary syndrome
One in ten women of reproductive age is likely to have polycystic ovary syndrome (PCOS), a complex endocrine disorder that...
FGF21 suppresses CD8+ T cell antitumour activity
FGF21 suppresses CD8+ T cell antitumour activity
Tumours can evade the immune system by suppressing the activity of immune cells within the tumour microenvironment (TME), ...
RalA links obesity and mitochondrial dysfunction
Obesity in humans and rodents is characterized by mitochondrial dysfunction, but what connects obesity and mitochondrial d...
Thyroid dysfunction in COVID-19
Thyroid dysfunction in COVID-19
The COVID-19 pandemic has affected over 772 million people globally. While lung damage is the major contributor to the mor...
Obesity and the kidney: mechanistic links and therapeutic advances
Obesity and the kidney: mechanistic links and therapeutic advances
Obesity is strongly associated with the development of diabetes mellitus and chronic kidney disease (CKD), but there is ev...
Consensus guideline for the diagnosis and management of pituitary adenomas in childhood and adolescence: Part 2, specific diseases
Pituitary adenomas are rare in children and young people under the age of 19 (hereafter referred to as CYP) but they pose ...
Sarcopenic obesity in older adults: a clinical overview
Sarcopenic obesity in older adults: a clinical overview
Sarcopenic obesity is characterized by a concurrent decline in muscle mass and function, along with increased adipose tiss...
Author Correction: Seeing through the fog: a neuroendocrine explanation for post-COVID cognitive deficits
Authors and AffiliationsUniversity of Lille, Inserm, CHU Lille, Lille Neuroscience & Cognition, FHU 1000 days for heal...
Pancreatic δ-cells influence the glycaemic set point
Pancreatic δ-cells influence the glycaemic set point
Somatostatin, produced by pancreatic δ-cells, has been known to inhibit insulin secretion since its discovery in the 1970s...
Dysfunctional lipid metabolism in ageing muscle: effects on glucose tolerance
Dysfunctional lipid metabolism in ageing muscle: effects on glucose tolerance
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
Targeting endometriosis
Endometriosis is a common disorder, affecting ~10% of women worldwide. However, despite this high prevalence, treatment op...