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A trio of trials on hormone receptor agonists for MASLD
A trio of trials on hormone receptor agonists for MASLD
A pressing need exists for drugs to treat metabolic dysfunction-associated steatotic liver disease (MASLD, previously refe...
Artemisinins as a promising treatment for polycystic ovary syndrome
Artemisinins as a promising treatment for polycystic ovary syndrome
One of the key drivers of polycystic ovary syndrome (PCOS) is androgen excess, which results in symptoms such as metabolic...
Post-burn endocrine–immune dynamics and ageing considerations
Post-burn endocrine–immune dynamics and ageing considerations
Thermal injuries trigger stress-induced endocrine responses that are critical for survival. With age, these responses falt...
The challenges of assessing adiposity in a clinical setting
The challenges of assessing adiposity in a clinical setting
To tackle the burden of obesity-induced cardiometabolic disease, the scientific community relies on accurate and reproduci...
PTH receptor signalling, osteocytes and bone disease induced by diabetes mellitus
PTH receptor signalling, osteocytes and bone disease induced by diabetes mellitus
Basic, translational and clinical research over the past few decades has provided new understanding on the mechanisms by w...
Metabolically healthy obesity: from epidemiology and mechanisms to clinical implications
Metabolically healthy obesity: from epidemiology and mechanisms to clinical implications
The concept of metabolic health, particularly in obesity, has attracted a lot of attention in the scientific community, an...
Progestin production by the gut microbiota
Progestin production by the gut microbiota
The gut microbiota has a role in modifying host steroids, but the exact nature of this interaction has been unclear. New r...
The relationship between the gut microbiota and thyroid disorders
The relationship between the gut microbiota and thyroid disorders
Disorders of the thyroid gland are common, more prevalent in women than in men, and range from inflammatory to neoplastic ...
Evidence for somatic mutation screening on aggressive prolactinomas
The recent Consensus Statement on the diagnosis and management of prolactin-secreting pituitary adenomas (prolactinomas) d...
Circulating non-coding RNA biomarkers of endocrine tumours
Circulating non-coding RNA biomarkers of endocrine tumours
Circulating non-coding RNA (ncRNA) molecules are being investigated as biomarkers of malignancy, prognosis and follow-up i...
The relationship between SARS-CoV-2 infection and type 1 diabetes mellitus
The relationship between SARS-CoV-2 infection and type 1 diabetes mellitus
Environmental factors, in particular viral infections, are thought to have an important role in the pathogenesis of type 1...
Debunking the myths of intermittent fasting
Despite the mounting evidence supporting the use of intermittent fasting as a safe and effective weight loss intervention,...
Mind the (human-based new approach methodology) gap!
The 1980s marked the beginning of the era of molecular biology; the sky was the limit for new technologies using complex g...
Gut hormones and bone homeostasis: potential therapeutic implications
Gut hormones and bone homeostasis: potential therapeutic implications
Bone resorption follows a circadian rhythm, with a marked reduction in circulating markers of resorption (such as carboxy-...
Metabolic alliance: pharmacotherapy and exercise management of obesity
Metabolic alliance: pharmacotherapy and exercise management of obesity
Anti-obesity medications based on incretin hormones have advanced weight control and metabolic health in individuals with ...
Diabetes mellitus in patients with acromegaly: pathophysiology, clinical challenges and management
Diabetes mellitus in patients with acromegaly: pathophysiology, clinical challenges and management
Acromegaly is a rare endocrine disease caused by hypersecretion of growth hormone, most commonly arising due to a pituitar...
NMDA receptor antagonist coupled to GLP1 analogue in highly effective experimental weight loss drug
NMDA receptor antagonist coupled to GLP1 analogue in highly effective experimental weight loss drug
Small-molecule drugs targeting the N-methyl-D-aspartate (NMDA) receptor, a glutamate-activated cation channel broadly expr...
Prediabetes remission for type 2 diabetes mellitus prevention
Current guidelines for the delay and prevention of type 2 diabetes mellitus recommend for people with prediabetes to lose ...
Sertoli cell lysosomal dysfunction drives age-related testicular degeneration
Sertoli cell lysosomal dysfunction drives age-related testicular degeneration
Late-onset hypogonadism (LOH) is an age-related disease affecting 2–6% of men >40 years old. LOH is a result of reduced...
Transcriptional control of metabolism by interferon regulatory factors
Transcriptional control of metabolism by interferon regulatory factors
Interferon regulatory factors (IRFs) comprise a family of nine transcription factors in mammals. IRFs exert broad effects ...
Obesity dysregulates a pituitary–liver axis through disruption of the unfolded protein response
Obesity dysregulates a pituitary–liver axis through disruption of the unfolded protein response
A recent study published in Cell Metabolism identifies a new mechanism by which obesity affects pituitary function through...
Advances in the management of achondroplasia
The first precision therapy for children with achondroplasia, vosoritide, is now approved in many regions, including Austr...
AMPK as a mediator of tissue preservation: time for a shift in dogma?
AMPK as a mediator of tissue preservation: time for a shift in dogma?
Ground-breaking discoveries have established 5′-AMP-activated protein kinase (AMPK) as a central sensor of metabolic...
Hearing abnormalities in patients treated with teprotumumab
Hearing abnormalities in patients treated with teprotumumab
The introduction of teprotumumab for the treatment of thyroid eye disease has dramatically improved management of this lif...
The role of brown adipose tissue in metabolic health
The role of brown adipose tissue in metabolic health
It is very well known that brown adipose tissue (BAT) is involved in thermogenesis, particularly in rodents. However, whet...
Publisher Correction: Arginine vasopressin deficiency: diagnosis, management and the relevance of oxytocin deficiency
Authors and AffiliationsDepartment of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzer...
Author Correction: Targeting the incretin system in obesity and type 2 diabetes mellitus
Authors and AffiliationsDivision of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UKSaleem Ansa...
Optimizing the treatment of hypothyroidism
Daily levothyroxine (LT4) is the standard of care for the treatment of hypothyroidism; however, a small number of patients...
A congress on head and neck paragangliomas: advancing clinical care
The First International Congress on Head and Neck Paragangliomas in 2023 launched a global initiative directed towards imp...
Thyroid function and iodine intake: global recommendations and relevant dietary trends
Thyroid function and iodine intake: global recommendations and relevant dietary trends
Iodine is a micronutrient that is essential for thyroid hormone production. Adequate iodine intake is especially important...
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