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The study that pioneered islet isolation techniques
In rodents, the endocrine pancreas consists of islets of Langerhans scattered throughout the exocrine acinar tissue and ac...
The enduring relevance of the Randle cycle
In people with diabetes mellitus, the heart is metabolically characterized by the excessive use of fatty acids and diminis...
Engineering adipocytes for cancer treatment
Engineering adipocytes for cancer treatment
Tumour cells are well known to have an altered metabolic profile and are more able to obtain and metabolize nutrients than...
Tryptophan metabolism, exercise and depression
Depression is linked to an altered stress response, as measured by elevated levels of cortisol and systemic inflammation. ...
Recent advances in treatments for congenital adrenal hyperplasia
The first CRFR1 antagonist (crinecerfont) to be used for the treatment of congenital adrenal hyperplasia recently received...
Hypoparathyroidism: diagnosis, management and emerging therapies
Hypoparathyroidism: diagnosis, management and emerging therapies
Hypoparathyroidism is characterized by inadequate parathyroid hormone (PTH) secretion or action and results in hypocalcaem...
Exercise exacerbates cardiac damage from high-fat, high-calorie feeding in mice
Exercise exacerbates cardiac damage from high-fat, high-calorie feeding in mice
Physical exercise is well known to help to prevent obesity and to benefit cardiometabolic health. A new study in Nature Co...
Exploring the functions of the myokine feimin
Exploring the functions of the myokine feimin
Skeletal muscle produces a range of myokines, which have various effects throughout the body. Two new studies published in...
The effects of type 1 and type 2 diabetes mellitus on bone health in chronic kidney disease
The effects of type 1 and type 2 diabetes mellitus on bone health in chronic kidney disease
Fracture is an under-recognized but common complication of diabetes mellitus, with an incidence approaching twofold in typ...
Management, biomarkers and prognosis in people developing endocrinopathies associated with immune checkpoint inhibitors
Management, biomarkers and prognosis in people developing endocrinopathies associated with immune checkpoint inhibitors
Immune-related adverse events (irAEs), including endocrine irAEs, can occur in response to cancer immunotherapy using immu...
Metabolic effects of gender-affirming hormone therapy
Metabolic effects of gender-affirming hormone therapy
As the field of gender-affirming hormone therapy (GAHT) evolves, research into how this type of treatment affects metaboli...
Illuminating the metabolic effects of circadian misalignment
Circadian misalignment affects physiology and metabolism and increases the risk of developing cardiometabolic disease. A p...
Enhancing adipose tissue plasticity: progenitor cell roles in metabolic health
Enhancing adipose tissue plasticity: progenitor cell roles in metabolic health
Adipose tissue demonstrates considerable plasticity and heterogeneity, enabling metabolic, cellular and structural adaptat...
Bile acid metabolism in type 2 diabetes mellitus
Bile acid metabolism in type 2 diabetes mellitus
Type 2 diabetes mellitus is a complex disorder associated with insulin resistance and hyperinsulinaemia that is insufficie...
International consensus guidelines on the implementation and monitoring of vosoritide therapy in individuals with achondroplasia
International consensus guidelines on the implementation and monitoring of vosoritide therapy in individuals with achondroplasia
Achondroplasia is the most common genetic form of short-limbed skeletal dysplasia (dwarfism). Clinical manifestations and ...
Identification of genetic factors of type 2 diabetes mellitus risk in South Asian populations
Identification of genetic factors of type 2 diabetes mellitus risk in South Asian populations
People of South Asian ancestry are more likely to develop type 2 diabetes mellitus (T2DM) at a younger age and lower BMI t...
From the perspective of a scientist with Cushing disease, what did not kill me made my science stronger
From the perspective of a scientist with Cushing disease, what did not kill me made my science stronger
Research siloes slow the translation of scientific discovery to patient care and limit progress in improving treatments fo...
Publisher Correction: Growth hormone-releasing hormone and its analogues in health and disease
Deceased: Andrew V. Schally.Department of Medical Sciences, University of Turin, Turin, ItalyRiccarda Granata, Iacopo Gesm...
Intermittent and periodic fasting in the treatment of obesity and type 2 diabetes mellitus
Several new clinical studies provide evidence for the potential of specific intermittent and periodic fasting intervention...
Advances in appetite regulation by the arcuate nucleus
Advances in appetite regulation by the arcuate nucleus
In 2024, new insights identified a cluster of leptin-targeted neurons and integrative networks that link sensory inputs (h...
Surveying the landscape of emerging osteoanabolic therapies
Established antiresorptive treatments for osteoporosis only slow down bone loss, and available osteoanabolic therapies ...
Advances in basic biology and translation in islet research
Advances in basic biology and translation in islet research
Advances in islet cell biology over the past few years highlight a fundamental role for intra-islet endocrine cell interac...
Advances in cardiometabolic outcomes in polycystic ovary syndrome
Advances in cardiometabolic outcomes in polycystic ovary syndrome
The year 2024 brought continuing research in the crucial field of adiposity-related health and polycystic ovary syndrome (...
Memory of obesity stored in adipocytes
Memory of obesity stored in adipocytes
In humans, weight loss as a result of lifestyle interventions, pharmacotherapy or bariatric surgery is often followed by w...
Consensus on the key characteristics of metabolism disruptors
Consensus on the key characteristics of metabolism disruptors
Metabolism-disrupting agents (MDAs) are chemical, infectious or physical agents that increase the risk of metabolic disord...
Author Correction: Growth hormone-releasing hormone and its analogues in health and disease
Deceased: Andrew V. Schally.Department of Medical Sciences, University of Turin, Turin, ItalyRiccarda Granata, Iacopo Gesm...
Polycystic ovary syndrome as a metabolic disease
Polycystic ovary syndrome as a metabolic disease
Polycystic ovary syndrome (PCOS) is a heterogeneous familial disorder affecting up to one in five women. The aetiology rem...
Opposing neuropeptides control cAMP signalling to regulate satiety
Opposing neuropeptides control cAMP signalling to regulate satiety
It is well known that neuropeptides have a key role in regulating feeding behaviour. However, many aspects of the mechanis...
Leveraging research into sex differences and steroid hormones to improve brain health
Leveraging research into sex differences and steroid hormones to improve brain health
Sex differences, driven in part by steroid hormones, shape the structure and function of the brain throughout the lifespan...
Sex differences in skeletal muscle metabolism in exercise and type 2 diabetes mellitus
Sex differences in skeletal muscle metabolism in exercise and type 2 diabetes mellitus
This Review focuses on currently available literature describing sex differences in skeletal muscle metabolism in humans, ...
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