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Highlights from SfE BES 2022
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Cardiorenal diseases in type 2 diabetes mellitus: clinical trials and real-world practice
Cardiorenal diseases in type 2 diabetes mellitus: clinical trials and real-world practice
Patients with type 2 diabetes mellitus (T2DM) can have multiple comorbidities and premature mortality due to atherosclerot...
Approaches to addressing the rise in obesity levels
Levels of obesity and overweight are increasing globally, with affected individuals often experiencing health issues and r...
Gene-edited organoids enable sensitive assessment of peptide hormone variation
Gene-edited organoids enable sensitive assessment of peptide hormone variation
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Metabolic determinants of tumour initiation
Metabolic determinants of tumour initiation
Tumours exhibit notable metabolic alterations compared with their corresponding normal tissue counterparts. These metaboli...
Genomics suggest role for IGF1 resistance in T2DM
Genomics suggest role for IGF1 resistance in T2DM
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Macrophage mitochondrial levels of iron affect adipose tissue function in obesity
Macrophage mitochondrial levels of iron affect adipose tissue function in obesity
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Promising findings in PTH replacement therapy trial
Promising findings in PTH replacement therapy trial
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REG3G — a potential link between the intestinal microbiome and host physiology
REG3G — a potential link between the intestinal microbiome and host physiology
The effects of the gut microbiota on host physiology, and potential mechanisms underlying these effects, have been debated...
Author Correction: Endosomal trafficking in metabolic homeostasis and diseases
Author notesThese authors contributed equally: Jerome Gilleron, Anja Zeigerer.Authors and AffiliationsUniversité Côte d’Az...
Engineered Tregs prevent diabetes mellitus in mice
Engineered Tregs prevent diabetes mellitus in mice
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Exercise in adults with type 1 diabetes mellitus
Exercise in adults with type 1 diabetes mellitus
Regular physical activity improves cardiometabolic and musculoskeletal health, helps with weight management, improves cogn...
Hypoglycaemia in type 1 diabetes mellitus: risks and practical prevention strategies
Hypoglycaemia in type 1 diabetes mellitus: risks and practical prevention strategies
Hypoglycaemia, which occurs when blood levels of glucose fall below what is considered a normal range, is a well-known com...
Functional HNF1A variants linked with T2DM risk in European-ancestry populations
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SARS-CoV-2 fires up inflammation in adipose tissue
SARS-CoV-2 fires up inflammation in adipose tissue
Obesity is an important risk factor for severe COVID-19 and, possibly, for breakthrough SARS-CoV-2 infections in fully vac...
Do psychedelics have therapeutic potential for obesity?
Do psychedelics have therapeutic potential for obesity?
Classic psychedelics are being revisited as novel drug candidates. Researchers are investigating the efficacy of psychedel...
Feasibility and effectiveness of time-restricted eating in different populations
Feasibility and effectiveness of time-restricted eating in different populations
Time-restricted eating (TRE) has a range of benefits for cardiometabolic health. However, the feasibility of TRE in many p...
Glucose metabolism after bariatric surgery: implications for T2DM remission and hypoglycaemia
Glucose metabolism after bariatric surgery: implications for T2DM remission and hypoglycaemia
Although promising therapeutics are in the pipeline, bariatric surgery (also known as metabolic surgery) remains our most ...
The role of insufficient sleep and circadian misalignment in obesity
The role of insufficient sleep and circadian misalignment in obesity
Traditional risk factors for obesity and the metabolic syndrome, such as excess energy intake and lack of physical activit...
Diagnosis of gestational diabetes mellitus: the debate continues
Diagnosis of gestational diabetes mellitus: the debate continues
A randomized controlled trial demonstrates that using lower glycaemic criteria for diagnosing and treating gestational dia...
Metformin and GDF15: where are we now?
Metformin and GDF15: where are we now?
A recent publication in Cell Reports adds to the emerging consensus that metformin acts on the gut and kidneys to increase...
Author Correction: Skeletal and extraskeletal disorders of biomineralization
These authors contributed equally: Michael T. Collins, Gemma MarcucciSkeletal Disorders and Mineral Homeostasis Section, N...
New role for bone marrow adipocytes in obesity
New role for bone marrow adipocytes in obesity
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Pancreatic mesenchymal stem cells might protect β-cells
Pancreatic mesenchymal stem cells might protect β-cells
A recent article from Science Translational Medicine demonstrated the importance of pancreas-derived mesenchymal stem cell...
Non-nutritive sweeteners — too sweet to be wholesome?
Non-nutritive sweeteners — too sweet to be wholesome?
Non-nutritive sweeteners (NNSs) seem to be a good substitute for sugar; they have the much-desired sweet taste but lack ca...
Timed high-fat diet feeding restores small bowel circadian rhythms
Timed high-fat diet feeding restores small bowel circadian rhythms
Host–microorganism circadian dynamics are key contributors to metabolic health. In addition, diet composition and ti...
The ATP-binding cassette proteins ABCB1 and ABCC1 as modulators of glucocorticoid action
The ATP-binding cassette proteins ABCB1 and ABCC1 as modulators of glucocorticoid action
Responses to hormones that act through nuclear receptors are controlled by modulating hormone concentrations not only in t...
The multiple roles of life stress in metabolic disorders
The multiple roles of life stress in metabolic disorders
The activation of stress-related neuroendocrine systems helps to maintain homeostasis, but excessive stress can damage bod...
Delving into insulin receptor regulation
Delving into insulin receptor regulation
Hyperinsulinaemia is associated with insulin resistance and insulin stimulation is known to reduce cell surface levels of ...
Defective UPR linked to β-cell dedifferentiation
Defective UPR linked to β-cell dedifferentiation
A decline in β-cell function is held accountable for the inability to secrete sufficient insulin in ageing patients with t...