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Advances in the management of achondroplasia
The first precision therapy for children with achondroplasia, vosoritide, is now approved in many regions, including Austr...
AMPK as a mediator of tissue preservation: time for a shift in dogma?
AMPK as a mediator of tissue preservation: time for a shift in dogma?
Ground-breaking discoveries have established 5′-AMP-activated protein kinase (AMPK) as a central sensor of metabolic...
Hearing abnormalities in patients treated with teprotumumab
Hearing abnormalities in patients treated with teprotumumab
The introduction of teprotumumab for the treatment of thyroid eye disease has dramatically improved management of this lif...
The role of brown adipose tissue in metabolic health
The role of brown adipose tissue in metabolic health
It is very well known that brown adipose tissue (BAT) is involved in thermogenesis, particularly in rodents. However, whet...
Publisher Correction: Arginine vasopressin deficiency: diagnosis, management and the relevance of oxytocin deficiency
Authors and AffiliationsDepartment of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzer...
Author Correction: Targeting the incretin system in obesity and type 2 diabetes mellitus
Authors and AffiliationsDivision of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UKSaleem Ansa...
Optimizing the treatment of hypothyroidism
Daily levothyroxine (LT4) is the standard of care for the treatment of hypothyroidism; however, a small number of patients...
A congress on head and neck paragangliomas: advancing clinical care
The First International Congress on Head and Neck Paragangliomas in 2023 launched a global initiative directed towards imp...
Thyroid function and iodine intake: global recommendations and relevant dietary trends
Thyroid function and iodine intake: global recommendations and relevant dietary trends
Iodine is a micronutrient that is essential for thyroid hormone production. Adequate iodine intake is especially important...
Arginine vasopressin deficiency: diagnosis, management and the relevance of oxytocin deficiency
Arginine vasopressin deficiency: diagnosis, management and the relevance of oxytocin deficiency
Polyuria–polydipsia syndrome can be caused by central diabetes insipidus, nephrogenic diabetes insipidus or primary ...
New genes associated with adult-onset obesity
New genes associated with adult-onset obesity
The factors that determine an individual’s body weight are highly complex and incompletely understood. Currently, >1,00...
Mild autonomous cortisol secretion: pathophysiology, comorbidities and management approaches
Mild autonomous cortisol secretion: pathophysiology, comorbidities and management approaches
The majority of incidentally discovered adrenal tumours are benign adrenocortical adenomas and the prevalence of adrenocor...
A novel system for non-invasive measurement of blood levels of glucose
A novel system for non-invasive measurement of blood levels of glucose
People with diabetes mellitus rely predominantly on finger pricking to measure blood levels of glucose, which can be onero...
Targeting the incretin system in obesity and type 2 diabetes mellitus
Targeting the incretin system in obesity and type 2 diabetes mellitus
Obesity and type 2 diabetes mellitus (T2DM) are widespread, non-communicable diseases that are responsible for considerabl...
Continuous glucose monitoring for the routine care of type 2 diabetes mellitus
Continuous glucose monitoring for the routine care of type 2 diabetes mellitus
Although continuous glucose monitoring (CGM) devices are now considered the standard of care for people with type 1 diabet...
Metformin acts through appetite-suppressing metabolite: Lac-Phe
Metformin acts through appetite-suppressing metabolite: Lac-Phe
Metformin is a first-line medication for type 2 diabetes mellitus (T2DM) that acts to reduce blood levels of glucose, food...
Protein tyrosine phosphatase 1B in metabolic diseases and drug development
Protein tyrosine phosphatase 1B in metabolic diseases and drug development
Protein tyrosine phosphatase 1B (PTP1B), a non-transmembrane phosphatase, has a major role in a variety of signal...
Tumour fibrosis in dopamine agonist-exposed prolactinomas is a diminishing concern
We applaud the Pituitary Society on the latest prolactinoma Consensus Statement (Petersenn, S. et al....
Sex differences in diabetic kidney disease explained
Sex differences in diabetic kidney disease explained
Diabetic kidney disease (DKD) is a common complication of diabetes mellitus and can lead to chronic kidney failure. Howeve...
Reply to ‘Tumour fibrosis in dopamine agonist-exposed prolactinomas is a diminishing concern’
The authors acknowledge all the other authors of Petersenn, S. et al. Diagnosis and management of prolactin-secreting pitu...
The hypothalamic–pituitary–gonadal axis and the enigma of Alzheimer disease sex differences
The hypothalamic–pituitary–gonadal axis and the enigma of Alzheimer disease sex differences
Alzheimer disease has a sex bias: women are twice as likely as men to be affected. Studies have linked elevated follicle-s...
Reply to ‘Slowly progressive insulin dependent diabetes mellitus in type 1 diabetes endotype 2’
We are grateful to Tetsuro Kobayashi and Takashi Kadowaki for their correspondence on our Review (Red...
Slowly progressive insulin-dependent diabetes mellitus in type 1 diabetes endotype 2
We have read with great interest the Review by Maria J. Redondo and Noel G. Morgan (Redondo, M.J., Mo...
Endocrine and cellular physiology and pathology of the insulin-like growth factor acid-labile subunit
Endocrine and cellular physiology and pathology of the insulin-like growth factor acid-labile subunit
The acid-labile subunit (ALS) of the insulin-like growth factor (IGF) binding protein (IGFBP) complex, encoded in humans b...
Inceptor loss in mice with obesity
Inceptor loss in mice with obesity
Inceptor (encoded by Iir) is a novel receptor that inhibits insulin receptor and insulin-like growth factor signalling. A ...
Metabolic regulation of skeletal cell fate and function
Metabolic regulation of skeletal cell fate and function
Bone development and bone remodelling during adult life are highly anabolic processes requiring an adequate supply of oxyg...
The individual response to antibiotics and diet — insights into gut microbial resilience and host metabolism
The individual response to antibiotics and diet — insights into gut microbial resilience and host metabolism
Antibiotic use disrupts microbial composition and activity in humans, but whether this disruption in turn affects host met...
Antibodies drive adipose tissue ageing
Antibodies drive adipose tissue ageing
The mechanisms underlying metabolic decline during ageing are not well understood. A new study in Cell Metabolism identifi...
Thyroid-function reference ranges in the diagnosis of thyroid dysfunction in adults
Applying a uniform reference range across all adults for serum levels of thyroid stimulating hormone and thyroid hormones ...
Controlling brown adipose tissue size through EPAC1
Controlling brown adipose tissue size through EPAC1
A new study by Reverte-Salisa and colleagues identifies a molecular mechanism through which the cAMP-mediating protein EPA...