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Identification of genetic factors of type 2 diabetes mellitus risk in South Asian populations
Identification of genetic factors of type 2 diabetes mellitus risk in South Asian populations
People of South Asian ancestry are more likely to develop type 2 diabetes mellitus (T2DM) at a younger age and lower BMI t...
From the perspective of a scientist with Cushing disease, what did not kill me made my science stronger
From the perspective of a scientist with Cushing disease, what did not kill me made my science stronger
Research siloes slow the translation of scientific discovery to patient care and limit progress in improving treatments fo...
Publisher Correction: Growth hormone-releasing hormone and its analogues in health and disease
Deceased: Andrew V. Schally.Department of Medical Sciences, University of Turin, Turin, ItalyRiccarda Granata, Iacopo Gesm...
Intermittent and periodic fasting in the treatment of obesity and type 2 diabetes mellitus
Several new clinical studies provide evidence for the potential of specific intermittent and periodic fasting intervention...
Advances in appetite regulation by the arcuate nucleus
Advances in appetite regulation by the arcuate nucleus
In 2024, new insights identified a cluster of leptin-targeted neurons and integrative networks that link sensory inputs (h...
Surveying the landscape of emerging osteoanabolic therapies
Established antiresorptive treatments for osteoporosis only slow down bone loss, and available osteoanabolic therapies ...
Advances in basic biology and translation in islet research
Advances in basic biology and translation in islet research
Advances in islet cell biology over the past few years highlight a fundamental role for intra-islet endocrine cell interac...
Advances in cardiometabolic outcomes in polycystic ovary syndrome
Advances in cardiometabolic outcomes in polycystic ovary syndrome
The year 2024 brought continuing research in the crucial field of adiposity-related health and polycystic ovary syndrome (...
Memory of obesity stored in adipocytes
Memory of obesity stored in adipocytes
In humans, weight loss as a result of lifestyle interventions, pharmacotherapy or bariatric surgery is often followed by w...
Consensus on the key characteristics of metabolism disruptors
Consensus on the key characteristics of metabolism disruptors
Metabolism-disrupting agents (MDAs) are chemical, infectious or physical agents that increase the risk of metabolic disord...
Author Correction: Growth hormone-releasing hormone and its analogues in health and disease
Deceased: Andrew V. Schally.Department of Medical Sciences, University of Turin, Turin, ItalyRiccarda Granata, Iacopo Gesm...
Polycystic ovary syndrome as a metabolic disease
Polycystic ovary syndrome as a metabolic disease
Polycystic ovary syndrome (PCOS) is a heterogeneous familial disorder affecting up to one in five women. The aetiology rem...
Opposing neuropeptides control cAMP signalling to regulate satiety
Opposing neuropeptides control cAMP signalling to regulate satiety
It is well known that neuropeptides have a key role in regulating feeding behaviour. However, many aspects of the mechanis...
Leveraging research into sex differences and steroid hormones to improve brain health
Leveraging research into sex differences and steroid hormones to improve brain health
Sex differences, driven in part by steroid hormones, shape the structure and function of the brain throughout the lifespan...
Sex differences in skeletal muscle metabolism in exercise and type 2 diabetes mellitus
Sex differences in skeletal muscle metabolism in exercise and type 2 diabetes mellitus
This Review focuses on currently available literature describing sex differences in skeletal muscle metabolism in humans, ...
Expanding applications of therapies based on GLP1
Expanding applications of therapies based on GLP1
The evidence base in support of the use of medicines based on glucagon-like peptide 1 beyond glucose control and weight lo...
Growth hormone-releasing hormone and its analogues in health and disease
Growth hormone-releasing hormone and its analogues in health and disease
Growth hormone-releasing hormone (GHRH) and its ability to stimulate the production and release of growth hormone from the...
Autologous stem-cell derived islets — the ultimate frontier in diabetes mellitus?
Autologous stem-cell derived islets — the ultimate frontier in diabetes mellitus?
A patient with longstanding type 1 diabetes mellitus has achieved insulin independence for at least 1 ye...
Macrophages support pancreatic development
Macrophages support pancreatic development
Engineering pancreatic tissue transplants to treat diabetes mellitus will require knowledge of how different cell types re...
Highlights from the Joint Irish–UK Endocrine Meeting 2024
This October, the first joint meeting between the Irish Endocrine Society (IES) and the British Society for Endocrinology ...
IL-17 has a role in whole-body homeostasis
IL-17 has a role in whole-body homeostasis
The immune system is known to have a circadian rhythm; however, how circadian rhythms might affect immune homeostasis and ...
Intricacies and obscurities of non-shivering thermogenesis
Mammalian cellular machinery has evolved to function best at ~37 °C, making maintenance of core body temperature (at ~37 °...
Our future, we decide: five ways to reform the scientific publication process
Our future, we decide: five ways to reform the scientific publication process
Although science is becoming ever more complex, interdisciplinary and open, the scientific publication process has largely...
Looking back at the TEDDY study: lessons and future directions
Looking back at the TEDDY study: lessons and future directions
The goal of the TEDDY (The Environmental Determinants of Diabetes in the Young) study is to elucidate factors lea...
Modelling human liver disease: from steatotic liver disease to MASH-HCC
Modelling human liver disease: from steatotic liver disease to MASH-HCC
Having more refined mouse models of metabolic dysfunction-associated steatotic liver disease (MASLD; also known as nonalco...
Publisher Correction: Current understanding of the molecular and cellular pathology of diabetic retinopathy
Publisher Correction: Current understanding of the molecular and cellular pathology of diabetic retinopathy
Authors and AffiliationsDepartment of Ophthalmology and Visual Sciences, Department of Molecular and Integrative Physiolog...
Limiting the use and misuse of liothyronine in hypothyroidism
Liothyronine treatment for some patients with hypothyroidism has preoccupied academics, clinicians and patients for decade...
The epidemiology of type 1 diabetes mellitus in older adults
The epidemiology of type 1 diabetes mellitus in older adults
Although type 1 diabetes mellitus (T1DM) is traditionally viewed as a youth-onset disorder, the number of older adults bei...
Inflammation and resolution in obesity
Inflammation and resolution in obesity
Inflammation is an essential physiological defence mechanism, but prolonged or excessive inflammation can cause disease. I...
Metformin in gestational diabetes: physiological actions and clinical applications
Metformin in gestational diabetes: physiological actions and clinical applications
Metformin is an effective oral hypoglycaemic agent used in the treatment of type 2 diabetes mellitus; however, its use in ...
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