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Increased cardiovascular risks and mortality in prurigo nodularis: a global cohort study
Increased cardiovascular risks and mortality in prurigo nodularis: a global cohort study
Volume 103, May 2024, 105123Author links open overlay panel, , , , , , , , SummaryBackgroundPrurigo nodularis (PN) present...
Projecting heat-related cardiovascular mortality burden attributable to human-induced climate change in China
Projecting heat-related cardiovascular mortality burden attributable to human-induced climate change in China
MethodsDaily data on CVD mortality and temperature were collected in 161 Chinese communities from 2007 to 2013. The associ...
Abdominal CT metrics in 17,646 patients reveal associations between myopenia, myosteatosis, and medical phenotypes: a phenome-wide association study
Abdominal CT metrics in 17,646 patients reveal associations between myopenia, myosteatosis, and medical phenotypes: a phenome-wide association study
KeywordsMyopeniaMyosteatosisPhenome wide association studyComputed tomographyAbbreviationsEHRElectronic health recordICDIn...
Impact of ambient air pollution on colorectal cancer risk and survival: insights from a prospective cohort and epigenetic Mendelian randomization study
Impact of ambient air pollution on colorectal cancer risk and survival: insights from a prospective cohort and epigenetic Mendelian randomization study
Volume 103, May 2024, 105126Author links open overlay panel, , , , , , , , , , , , , , SummaryBackgroundThis study investi...
Sanger sequencing and deconvolution of polyclonal infections: a quantitative approach to monitor drug-resistant Plasmodium falciparum
Sanger sequencing and deconvolution of polyclonal infections: a quantitative approach to monitor drug-resistant Plasmodium falciparum
BackgroundAnti-malarial drug resistance in Plasmodium falciparum is a major public health problem in malaria-endemic regio...
GAA/FGF14 ataxia: an ode to the phenotype-first approach
GAA/FGF14 ataxia: an ode to the phenotype-first approach
Volume 103, May 2024, 105131Author links open overlay panelElisabetta Indelicato, Sylvia BoeschShow morePrevious article i...
Intratumoral CD38+CD19+B cells associate with poor clinical outcomes and immunosuppression in patients with pancreatic ductal adenocarcinoma
Intratumoral CD38+CD19+B cells associate with poor clinical outcomes and immunosuppression in patients with pancreatic ductal adenocarcinoma
BackgroundThe widespread involvement of tumor-infiltrating B cells highlights their potential role in tumor behavior. Howe...
Global transmission of extended-spectrum cephalosporin resistance in Escherichia coli driven by epidemic plasmids
Global transmission of extended-spectrum cephalosporin resistance in Escherichia coli driven by epidemic plasmids
BackgroundExtended-spectrum cephalosporins (ESCs) are third and fourth generation cephalosporin antimicrobials used in hum...
Circulating tumour DNA-Based molecular residual disease detection in resectable cancers: a systematic review and meta-analysis
Circulating tumour DNA-Based molecular residual disease detection in resectable cancers: a systematic review and meta-analysis
BackgroundCirculating tumour DNA (ctDNA)-based molecular residual disease (MRD) detection technology has been widely used ...
Multimodal detection and analysis of microplastics in human thrombi from multiple anatomically distinct sites
Multimodal detection and analysis of microplastics in human thrombi from multiple anatomically distinct sites
BackgroundMicroplastic (MP) pollution has emerged as a significant environmental concern worldwide. While extensive resear...
Biomarkers for phenotype-endotype relationship in atopic dermatitis: a critical review
Biomarkers for phenotype-endotype relationship in atopic dermatitis: a critical review
Volume 103, May 2024, 105121Author links open overlay panel, , , SummaryAtopic dermatitis (AD) is the most common form of ...
Chemically engineered mTOR-nanoparticle blockers enhance antitumour efficacy
Chemically engineered mTOR-nanoparticle blockers enhance antitumour efficacy
Volume 103, May 2024, 105099Author links open overlay panel, , , , , , , , , , , , , SummaryBackgroundHepatocellular carci...
Corrigendum to “TRAF4 acts as a fate checkpoint to regulate the adipogenic differentiation of MSCs by activating PKM2” [eBioMedicine 54(2020) 102722]
Corrigendum to “TRAF4 acts as a fate checkpoint to regulate the adipogenic differentiation of MSCs by activating PKM2” [eBioMedicine 54(2020) 102722]
Volume 103, May 2024, 105117Author links open overlay panelShuizhong Cen a b d, Jinteng Li a d, Zhaopeng Cai a d, Yiqian P...
Cholesterol accumulation in ccRCC: the role of ccRCC-initiating VHL-HIFα pathway
Cholesterol accumulation in ccRCC: the role of ccRCC-initiating VHL-HIFα pathway
Volume 103, May 2024, 105112Author links open overlay panelM. Aiman Mohtar, Siti Nur Hasanah Mohd Yusuf, Saiful Effendi Sy...
Covalent conjugation of AZD8055 with unsaturated fatty acids for the development of mTOR nanoblockers: increasing the therapeutic efficacy of hepatocellular carcinoma treatment
Covalent conjugation of AZD8055 with unsaturated fatty acids for the development of mTOR nanoblockers: increasing the therapeutic efficacy of hepatocellular carcinoma treatment
Volume 103, May 2024, 105113Author links open overlay panelWing Ki Chau a, Terence Kin Wah Lee a bShow morePrevious articl...
Remote monitoring of amyotrophic lateral sclerosis using wearable sensors detects differences in disease progression and survival: a prospective cohort study
Remote monitoring of amyotrophic lateral sclerosis using wearable sensors detects differences in disease progression and survival: a prospective cohort study
BackgroundThere is an urgent need for objective and sensitive measures to quantify clinical disease progression and gauge ...
Virological response to nucleos(t)ide analogues treatment in chronic hepatitis B patients is associated with Bacteroides-dominant gut microbiome
Virological response to nucleos(t)ide analogues treatment in chronic hepatitis B patients is associated with Bacteroides-dominant gut microbiome
Volume 103, May 2024, 105101Author links open overlay panel, , , , , , , SummaryBackgroundGut dysbiosis is present in chro...
Mitotic abnormalities precede microsatellite instability in lynch syndrome-associated colorectal tumourigenesis
Mitotic abnormalities precede microsatellite instability in lynch syndrome-associated colorectal tumourigenesis
Volume 103, May 2024, 105111Author links open overlay panel, , , , , , , , , , , , , , SummaryBackgroundLynch syndrome (LS...
A phenome-wide association and Mendelian randomisation study of alcohol use variants in a diverse cohort comprising over 3 million individuals
A phenome-wide association and Mendelian randomisation study of alcohol use variants in a diverse cohort comprising over 3 million individuals
BackgroundAlcohol consumption is associated with numerous negative social and health outcomes. These associations may be d...
Which behaviour change techniques work best for diabetes self-management mobile apps? Results from a systematic review and meta-analysis of randomised controlled trials
Which behaviour change techniques work best for diabetes self-management mobile apps? Results from a systematic review and meta-analysis of randomised controlled trials
Volume 103, May 2024, 105091Author links open overlay panel, , , , SummaryBackgroundSelf-management is pivotal in addressi...
Causal dynamics of sleep, circadian rhythm, and mood symptoms in patients with major depression and bipolar disorder: insights from longitudinal wearable device data
Causal dynamics of sleep, circadian rhythm, and mood symptoms in patients with major depression and bipolar disorder: insights from longitudinal wearable device data
BackgroundSleep and circadian rhythm disruptions are common in patients with mood disorders. The intricate relationship be...
MMP-9 release into collateral blood vessels before endovascular thrombectomy to assess the risk of major intracerebral haemorrhages and poor outcome for acute ischaemic stroke: a proof-of-concept study
MMP-9 release into collateral blood vessels before endovascular thrombectomy to assess the risk of major intracerebral haemorrhages and poor outcome for acute ischaemic stroke: a proof-of-concept study
BackgroundMatrix metalloproteinases (MMPs) are implied in blood–brain barrier degradation and haemorrhagic transformation ...
The clinical manifestations and molecular pathogenesis of radiation fibrosis
The clinical manifestations and molecular pathogenesis of radiation fibrosis
Advances in radiation techniques have enabled the precise delivery of higher doses of radiotherapy to tumours, while spari...
Steroids-producing nodules: a two-layered adrenocortical nodular structure as a precursor lesion of cortisol-producing adenoma
Steroids-producing nodules: a two-layered adrenocortical nodular structure as a precursor lesion of cortisol-producing adenoma
BackgroundThe human adrenal cortex consists of three functionally and structurally distinct layers; zona glomerulosa, zona...
CHRFAM7A diversifies human immune adaption through Ca2+ signalling and actin cytoskeleton reorganization
CHRFAM7A diversifies human immune adaption through Ca2+ signalling and actin cytoskeleton reorganization
BackgroundHuman restricted genes contribute to human specific traits in the immune system. CHRFAM7A, a uniquely human fusi...
Enhanced resolution profiling in twins reveals differential methylation signatures of type 2 diabetes with links to its complications
Enhanced resolution profiling in twins reveals differential methylation signatures of type 2 diabetes with links to its complications
Volume 103, May 2024, 105096Author links open overlay panel, , , , , , , , , , , , , , , , , , , …SummaryBackgroundType 2 ...
Ipsilateral and contralateral coadministration of influenza and COVID-19 vaccines produce similar antibody responses
Ipsilateral and contralateral coadministration of influenza and COVID-19 vaccines produce similar antibody responses
Volume 103, May 2024, 105103Author links open overlay panel, , , , , , , , , , , SummaryBackgroundWorld Health Organisatio...
Retraction notice to ‘MicroRNA-134 prevents the progression of esophageal squamous cell carcinoma via the PLXNA1-mediated MAPK signalling pathway’ [EBioMedicine 46 (2019) 66–78]
Retraction notice to ‘MicroRNA-134 prevents the progression of esophageal squamous cell carcinoma via the PLXNA1-mediated MAPK signalling pathway’ [EBioMedicine 46 (2019) 66–78]
Volume 103, May 2024, 105105Author links open overlay panelWei-Wei Wang a b c f, Zhi-Hua Zhao a b c f, Li Wang a b c, Pan ...
Retraction notice to “Corrigendum to ‘MicroRNA-134 prevents the progression of esophageal squamous cell carcinoma via the PLXNA1-mediated MAPK signalling pathway’ [EBioMedicine 46 (2019) 66–78]” [EBioMedicine 55 (2020) 102772]
Retraction notice to “Corrigendum to ‘MicroRNA-134 prevents the progression of esophageal squamous cell carcinoma via the PLXNA1-mediated MAPK signalling pathway’ [EBioMedicine 46 (2019) 66–78]” [EBioMedicine 55 (2020) 102772]
Volume 103, May 2024, 105106Author links open overlay panelWei-Wei Wang a b c f, Zhi-Hua Zhao a b c f, Li Wang a b c, Pan ...
Using generative AI to investigate medical imagery models and datasets
Using generative AI to investigate medical imagery models and datasets
BackgroundAI models have shown promise in performing many medical imaging tasks. However, our ability to explain what sign...
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