SCI时时刷

search
+
A Bayesian approach to predictive uncertainty in chemotherapy patients at risk of acute care utilization
BackgroundMachine learning (ML) predictions are becoming increasingly integrated into medical practice. One commonly used ...
IL-17C neutralization protects the kidney against acute injury and chronic injury
BackgroundInterleukin-17C (IL-17C), a member of the IL-17 cytokine family, plays a pathogenic role in kidney diseases. Our...
A pentasaccharide for monitoring pharmacodynamic response to gene therapy in GM1 gangliosidosis
BackgroundGM1 gangliosidosis is a rare, fatal, neurodegenerative disease caused by mutations in the GLB1 gene and deficien...
Neurosteroid pathway derangement in asphyctic infants treated with hypothermia: an untargeted metabolomic approach
BackgroundThe pathobiological mechanisms associated with perinatal asphyxia and hypoxic-ischemic encephalopathy are comple...
Pancreatic ductal adenocarcinoma ubiquitination profiling reveals specific prognostic and theranostic markers
BackgroundPancreatic ductal adenocarcinoma (PDAC) has been widely studied at multiomics level. However, little is known ab...
Dilated Virchow-Robin spaces are a marker for arterial disease in multiple sclerosis
KeywordsMultiple sclerosis (MS)Perivascular spacesVirchow-Robin spacesMagnetic resonance imaging (MRI)Clinical studyGlossa...
Immunoscore immune checkpoint using spatial quantitative analysis of CD8 and PD-L1 markers is predictive of the efficacy of anti- PD1/PD-L1 immunotherapy in non-small cell lung cancer
BackgroundAnti-PD-1 and PD-L1 antibodies (mAbs) are approved immunotherapy agents to treat metastatic non-small cell lung ...
Juvenile CLN3 disease is a lysosomal cholesterol storage disorder: similarities with Niemann-Pick type C disease
BackgroundThe most common form of neuronal ceroid lipofuscinosis (NCL) is juvenile CLN3 disease (JNCL), a currently incura...
Temporal characterization of Alzheimer's Disease with sequences of clinical records
BackgroundAlzheimer's Disease (AD) is a complex clinical phenotype with unprecedented social and economic tolls on an agei...
Evaluation of pre-diagnostic blood protein measurements for predicting survival after lung cancer diagnosis
eBioMedicineVolume 92, June 2023, 104623Author links open overlay panel, , , , , , , , , , , , , , , , , , , …SummaryBackg...
Visualising SARS-CoV-2 infection of the lung in deceased COVID-19 patients
BackgroundSARS-CoV-2 is a single-stranded positive-sense RNA virus. Several negative-sense SARS-CoV-2 RNA species, both fu...
Global distributions of age- and sex-related arterial stiffness: systematic review and meta-analysis of 167 studies with 509,743 participants
BackgroundArterial stiffening is central to the vascular ageing process and a powerful predictor and cause of diverse vasc...
Identification of cervical cancer stem cells using single-cell transcriptomes of normal cervix, cervical premalignant lesions, and cervical cancer
BackgroundCervical cancer is the fourth leading cause of mortality among gynecological malignancies. However, the identifi...
Gene expression signature predicts rate of type 1 diabetes progression
BackgroundType 1 diabetes is a complex heterogenous autoimmune disease without therapeutic interventions available to prev...
Patient-derived melanoma organoid models facilitate the assessment of immunotherapies
BackgroundOnly a minority of melanoma patients experience durable responses to immunotherapies due to inter- and intra-tum...
Cross-tissue omics analysis discovers ten adipose genes encoding secreted proteins in obesity-related non-alcoholic fatty liver disease
BackgroundNon-alcoholic fatty liver disease (NAFLD) is a fast-growing, underdiagnosed, epidemic. We hypothesise that obesi...
Dissecting the genetic heterogeneity of gastric cancer
BackgroundGastric cancer (GC) is clinically heterogenous according to location (cardia/non-cardia) and histopathology (dif...
Evolution of age-related mutation-driven clonal haematopoiesis over 20 years is associated with metabolic dysfunction in obesity
eBioMedicineVolume 92, June 2023, 104621Author links open overlay panel, , , , , , , , , , , , , , , , SummaryBackgroundHa...
Disentangling the genetic overlap and causal relationships between primary open-angle glaucoma, brain morphology and four major neurodegenerative disorders
BackgroundPrimary open-angle glaucoma (POAG) is an optic neuropathy characterized by progressive degeneration of the optic...
Magnesium increases numbers of Foxp3+ Treg cells and reduces arthritis severity and joint damage in an IL-10-dependent manner mediated by the intestinal microbiome
eBioMedicineVolume 92, June 2023, 104603Author links open overlay panel, , , , , SummaryBackgroundRheumatoid arthritis (RA...
The next frontier of early lung cancer and minimal residual disease detection: is multiomics the solution?
eBioMedicineVolume 92, June 2023, 104605Author links open overlay panelChristian Rolfo a d, Alessandro Russo b d, Umberto ...
Dengue fever: the impact of increasing temperatures and heatwaves
eBioMedicineVolume 92, June 2023, 104611Author links open overlay panelFrancesca D. FrentiuShow morePrevious article in is...
New evidence for the role of gut microbiota on atrial fibrillation development
eBioMedicineVolume 92, June 2023, 104622Author links open overlay panelChristopher Papandreou a b cShow morePrevious artic...
Association of HLA diversity with the risk of 25 cancers in the UK Biobank
BackgroundThe human leukocyte antigen (HLA) is a highly polymorphic region, and HLA diversity may play a role in presentin...
Priming therapy by targeting enhancer-initiated pathways in patient-derived pancreatic cancer cells
eBioMedicineVolume 92, June 2023, 104602Author links open overlay panel, , , , , , , , , , , , SummaryBackgroundSystems bi...
Single-cell profiling of low-stage endometrial cancers identifies low epithelial vimentin expression as a marker of recurrent disease
eBioMedicineVolume 92, June 2023, 104595Author links open overlay panel, , , , , , SummaryBackgroundIdentification of aggr...
Human mesenchymal stem cell therapy in severe COVID-19 patients: 2-year follow-up results of a randomized, double-blind, placebo-controlled trial
eBioMedicineVolume 92, June 2023, 104600Author links open overlay panel, , , , , , , , , , , , , , , , , , , …SummaryBackg...
Genome-wide CRISPR/Cas9 screening identifies a targetable MEST-PURA interaction in cancer metastasis
eBioMedicineVolume 92, June 2023, 104587Author links open overlay panel, , , , , , , , , , , , , , , SummaryBackgroundMeta...
Post COVID-19 condition after delta infection and omicron reinfection in children and adolescents
eBioMedicineVolume 92, June 2023, 104599Author links open overlay panel, , , , , , , Bergen COVID-19 research groupSummary...
Intranasal administration of convalescent plasma protects against SARS-CoV-2 infection in hamsters
eBioMedicineVolume 92, June 2023, 104597Author links open overlay panel, , , , , , , , , , SummaryBackgroundConvalescent p...
阅读更多
format_indent_increase