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The aberrant epigenome of DNMT3B-mutated ICF1 patient iPSCs is amenable to correction, with the exception of a subset of regions with H3K4me3- and/or CTCF-based epigenetic memory [RESEARCH]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Genome-wide evaluation of the effect of short tandem repeat variation on local DNA methylation [RESEARCH]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Regulation of endogenous retrovirus-derived regulatory elements by GATA2/3 and MSX2 in human trophoblast stem cells [RESEARCH]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Atlas-scale single-cell chromatin accessibility using nanowell-based combinatorial indexing [METHODS]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Matching queried single-cell open-chromatin profiles to large pools of single-cell transcriptomes and epigenomes for reference supported analysis [METHODS]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Characterization of network hierarchy reflects cell state specificity in genome organization [METHODS]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Complex hierarchical structures in single-cell genomics data unveiled by deep hyperbolic manifold learning [METHODS]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
A temporal in vivo catalog of chromatin accessibility and expression profiles in pineoblastoma reveals a prevalent role for repressor elements [RESOURCES]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
The Planemo toolkit for developing, deploying, and executing scientific data analyses in Galaxy and beyond [RESOURCES]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
A chromosome-scale epigenetic map of the Hydra genome reveals conserved regulators of cell state [RESOURCES]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Active enhancers strengthen insulation by RNA-mediated CTCF binding at chromatin domain boundaries [RESEARCH]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Multi-omics analyses demonstrate a critical role for EHMT1 methyltransferase in transcriptional repression during oogenesis [RESEARCH]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Diversity, duplication, and genomic organization of homeobox genes in Lepidoptera [RESEARCH]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Rates and spectra of de novo structural mutations in Chlamydomonas reinhardtii [RESEARCH]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
An efficient genotyper and star-allele caller for pharmacogenomics [METHOD]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Marker-free characterization of full-length transcriptomes of single live circulating tumor cells [METHOD]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
A somatic hypermutation-based machine learning model stratifies individuals with Crohn's disease and controls [METHOD]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Nematode gene annotation by machine-learning-assisted proteotranscriptomics enables proteome-wide evolutionary analysis [METHOD]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Cross-species cell-type assignment from single-cell RNA-seq data by a heterogeneous graph neural network [METHOD]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Dynamic regulation of gonadal transposon control across the lifespan of the naturally short-lived African turquoise killifish [RESOURCES]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Robust analysis of prokaryotic pangenome gene gain and loss rates with Panstripe [METHOD]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Genome sequencing of C. elegans balancer strains reveals previously unappreciated complex genomic rearrangements [RESOURCES]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Non-Mendelian inheritance patterns and extreme deviation rates of CGG repeats in autism [RESEARCH]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Redistribution of lamina-associated domains reshapes binding of pioneer factor FOXA2 in development of nonalcoholic fatty liver disease [RESEARCH]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Gene essentiality in cancer cell lines is modified by the sex chromosomes [RESEARCH]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Systematic transcriptome analysis associated with physiological and chronological aging in Caenorhabditis elegans [RESEARCH]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Genetic exchange with an outcrossing sister species causes severe genome-wide dysregulation in a selfing Caenorhabditis nematode [RESEARCH]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Hybridization drives mitochondrial DNA degeneration and metabolic shift in a species with biparental mitochondrial inheritance [RESEARCH]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Developmental timing of programmed DNA elimination in Paramecium tetraurelia recapitulates germline transposon evolutionary dynamics [RESEARCH]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Three assays for in-solution enrichment of ancient human DNA at more than a million SNPs [METHOD]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
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