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Fusion‐Positive Salivary Gland Carcinomas
Fusion‐Positive Salivary Gland Carcinomas
Abstract Salivary gland tumors are a rare, heterogeneous group of neoplasms that pose significant diagnostic challenges fo...
Recurrent PTBP1‐MAML2 fusions in composite hemangioendothelioma with neuroendocrine differentiation: A report of two cases involving neck lymph nodes
Recurrent PTBP1‐MAML2 fusions in composite hemangioendothelioma with neuroendocrine differentiation: A report of two cases involving neck lymph nodes
Abstract Composite hemangioendothelioma (CHE) displaying neuroendocrine differentiation is a rare histologic variant that ...
Comprehensive analyses of microRNA and mRNA expression in colorectal serrated lesions and colorectal cancer with a microsatellite instability phenotype
Comprehensive analyses of microRNA and mRNA expression in colorectal serrated lesions and colorectal cancer with a microsatellite instability phenotype
Abstract MicroRNA (miRNA) expression is dysregulated in human tumors, thereby contributing to tumorigenesis through altere...
Novel EWSR1‐UBP1 fusion expands the spectrum of spindle cell rhabdomyosarcomas
Novel EWSR1‐UBP1 fusion expands the spectrum of spindle cell rhabdomyosarcomas
Abstract Over the last decade, the development of next-generation sequencing techniques has led to the molecular dismantle...
A YAP1::TFE3 Cutaneous Low‐Grade Fibromyxoid Neoplasm: A Novel Entity!
A YAP1::TFE3 Cutaneous Low‐Grade Fibromyxoid Neoplasm: A Novel Entity!
Abstract Cutaneous fibromyxoid neoplasms (CFMN) comprise a vast category of benign and malignant tumors that include, but ...
Recurrent PTBP1‐MAML2 Fusions in Composite Hemangioendothelioma with Neuroendocrine Differentiation: A Report of 2 cases Involving Neck Lymph Nodes
Recurrent PTBP1‐MAML2 Fusions in Composite Hemangioendothelioma with Neuroendocrine Differentiation: A Report of 2 cases Involving Neck Lymph Nodes
Abstract Composite hemangioendothelioma (CHE) displaying neuroendocrine differentiation is a rare histologic variant that ...
Comprehensive analyses of microRNA and mRNA expression in colorectal serrated lesions and colorectal cancer with a MSI phenotype
Comprehensive analyses of microRNA and mRNA expression in colorectal serrated lesions and colorectal cancer with a MSI phenotype
Abstract MicroRNA (miRNA) expression is dysregulated in human tumors, thereby contributing to tumorigenesis through altere...
MammaPrint and BluePrint comprehensively capture the cancer hallmarks in early‐stage breast cancer patients
MammaPrint and BluePrint comprehensively capture the cancer hallmarks in early‐stage breast cancer patients
Abstract MammaPrint® (MP) is a 70-gene signature that stratifies early-stage breast cancer patients into low- and hig...
Mismatch Repair Deficiency: The What, How and Why It is Important
Mismatch Repair Deficiency: The What, How and Why It is Important
ABSTRACT The mismatch repair system is a major pathway that functions in the maintenance of genomic integrity. It is invol...
Upfront progression under pembrolizumab followed by a complete response after encorafenib and cetuximab treatment in BRAF V600E‐mutated and microsatellite unstable metastatic colorectal cancer patient: a case report
Upfront progression under pembrolizumab followed by a complete response after encorafenib and cetuximab treatment in BRAF V600E‐mutated and microsatellite unstable metastatic colorectal cancer patient: a case report
Abstract Two new treatments have recently become standard of care for patients with metastatic colorectal cancer (mCRC): e...
Molecular Analysis of 10 Pleomorphic Rhabdomyosarcomas Reveals Potential Prognostic Markers and Druggable Targets
Molecular Analysis of 10 Pleomorphic Rhabdomyosarcomas Reveals Potential Prognostic Markers and Druggable Targets
Abstract Pleomorphic rhabdomyosarcoma (PRMS) is a rare and aggressive adult sarcoma with a median overall survival of less...
Survey of Germline Variants in Cancer‐Associated Genes in Young Adults with Colorectal Cancer
Survey of Germline Variants in Cancer‐Associated Genes in Young Adults with Colorectal Cancer
Abstract Colorectal cancer (CRC) incidence in young adults is rising. Identifying genetic risk factors is fundamental for ...
Expanding the clinicopathological spectrum of TGFBR3‐PLAG1 rearranged salivary gland neoplasms with myoepithelial differentiation including evidence of high‐grade transformation
Expanding the clinicopathological spectrum of TGFBR3‐PLAG1 rearranged salivary gland neoplasms with myoepithelial differentiation including evidence of high‐grade transformation
Abstract PLAG1 rearrangements have been described as a molecular hallmark of salivary gland pleomorphic adenoma (PA), carc...
Clinicopathologic and Survival Correlates of Embryonal Rhabdomyosarcoma Driven by RAS/RAF Mutations
Clinicopathologic and Survival Correlates of Embryonal Rhabdomyosarcoma Driven by RAS/RAF Mutations
Abstract Embryonal rhabdomyosarcoma (ERMS) is the most common subtype of rhabdomyosarcoma (RMS). Amongst RMS subtypes, ERM...
Neuregulin 1 (NRG1) fusion‐positive high‐grade spindle cell sarcoma: a distinct group of soft tissue tumors with metastatic potential
Neuregulin 1 (NRG1) fusion‐positive high‐grade spindle cell sarcoma: a distinct group of soft tissue tumors with metastatic potential
Abstract Neuregulin 1 (NRG1) is an epidermal growth factor (EGF)-like ligand that activates receptor tyrosine kinases of t...
Clinicopathological features and resistance mechanisms in HIP1‐ALK‐rearranged lung cancer: A multicenter study
Clinicopathological features and resistance mechanisms in HIP1‐ALK‐rearranged lung cancer: A multicenter study
Abstract Anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC) respond well to ALK tyrosine kinas...
Comparison of myeloid neoplasms with nonclassic 3q26.2/MECOM versus classic inv(3)/t(3;3) rearrangements reveals diverse clinicopathologic features, genetic profiles, and molecular mechanisms of MECOM activation
Comparison of myeloid neoplasms with nonclassic 3q26.2/MECOM versus classic inv(3)/t(3;3) rearrangements reveals diverse clinicopathologic features, genetic profiles, and molecular mechanisms of MECOM activation
Abstract MECOM rearrangements are recurrent in myeloid neoplasms and associated with poor prognosis. However, only inv(3)(...
Translocation Carcinomas of the Kidney
Translocation Carcinomas of the Kidney
Abstract The MiT subfamily of transcription factors includes TFE3, TFEB, TFEC, and MITF. Gene fusions involving two of the...
Rare germline variants in childhood cancer patients suspected of genetic predisposition to cancer
Rare germline variants in childhood cancer patients suspected of genetic predisposition to cancer
Abstract Identification of cancer-predisposing germline variants in childhood cancer patients is important for therapeutic...
Clinicopathological features and resistance mechanism in HIP1‐ALK‐rearranged lung cancer: A multicenter study
Clinicopathological features and resistance mechanism in HIP1‐ALK‐rearranged lung cancer: A multicenter study
Abstract Anaplastic lymphoma kinase (ALK)- rearranged non-small cell lung cancer (NSCLC) respond well to ALK tyrosine kina...
Comparison of myeloid neoplasms with non‐classic 3q26.2/MECOM vs classic inv(3)/t(3;3) rearrangements reveals diverse clinicopathologic features, genetic profiles and molecular mechanisms of MECOM activation
Comparison of myeloid neoplasms with non‐classic 3q26.2/MECOM vs classic inv(3)/t(3;3) rearrangements reveals diverse clinicopathologic features, genetic profiles and molecular mechanisms of MECOM activation
Abstract MECOM rearrangements are recurrent in myeloid neoplasms and associated with poor prognosis. However, only inv(3)(...
Transcriptome sequencing of archived lymphoma specimens is feasible and clinically relevant using exome capture technology
Transcriptome sequencing of archived lymphoma specimens is feasible and clinically relevant using exome capture technology
Abstract Formalin-fixed, paraffin-embedded (FFPE) specimens are an underutilized resource in medical research, particularl...
Low‐grade Endometrial Stromal Sarcoma‐like Tumors in Male with JAZF1 Gene Fusions
Low‐grade Endometrial Stromal Sarcoma‐like Tumors in Male with JAZF1 Gene Fusions
Abstract Low-grade endometrial stromal sarcoma (ESS) is a hormone-responsive low-grade sarcoma typically occurring in the ...
Undifferentiated sarcoma of bone with a round to epithelioid cell phenotype harboring a novel EWSR1‐SSX2 fusion identified by RNA‐based next‐generation sequencing
Undifferentiated sarcoma of bone with a round to epithelioid cell phenotype harboring a novel EWSR1‐SSX2 fusion identified by RNA‐based next‐generation sequencing
Abstract Due to the increased application of RNA-based next-generation sequencing techniques on bone and soft tissue round...
Ovarian germ cell tumor/mastocytosis with KIT mutation: a unique clinicopathological entity
Ovarian germ cell tumor/mastocytosis with KIT mutation: a unique clinicopathological entity
ABSTRACT Most tumors are sporadic and originated from somatic mutations. Some rare germline mutations cause familial tumor...
An undifferentiated sarcoma of bone with a round to epithelioid cell phenotype harboring a novel EWSR1‐SSX2 fusion identified by RNA‐based next‐generation sequencing
An undifferentiated sarcoma of bone with a round to epithelioid cell phenotype harboring a novel EWSR1‐SSX2 fusion identified by RNA‐based next‐generation sequencing
Abstract Due to the increased application of RNA-based next-generation sequencing techniques on bone and soft tissue round...
Balanced and unbalanced translocations in a multicentric series of 2843 patients with chronic lymphocytic leukemia
Balanced and unbalanced translocations in a multicentric series of 2843 patients with chronic lymphocytic leukemia
Abstract Chromosomal translocations in chronic lymphocytic leukemia (CLL) are very rare, and therefore systematic analysis...
Cryptic TCF3 fusions in childhood leukemia – detection by RNA‐sequencing
Cryptic TCF3 fusions in childhood leukemia – detection by RNA‐sequencing
Abstract Acute lymphoblastic leukemia (ALL) is the most frequent malignancy in childhood and adolescence. In more than 60%...
Assessing acute myeloid leukemia susceptibility in rearrangement‐driven patients by DNA breakage at topoisomerase II and CCCTC‐binding factor/cohesin binding sites
Assessing acute myeloid leukemia susceptibility in rearrangement‐driven patients by DNA breakage at topoisomerase II and CCCTC‐binding factor/cohesin binding sites
Abstract An initiating DNA double strand break (DSB) event precedes the formation of cancer-driven chromosomal abnormaliti...
Recurrent NF1 gene variants and their genotype/phenotype correlations in patients with Neurofibromatosis type I
Recurrent NF1 gene variants and their genotype/phenotype correlations in patients with Neurofibromatosis type I
Abstract Neurofibromatosis type I, a genetic condition due to pathogenic variants in the NF1 gene, is burdened by a high r...
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