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Adoptive Transfer of Activated Immune Cells against Solid Tumors: A Preliminary Study
Available online 27 September 2022, 104616Highlights•Novel cellular therapy against solid tumors.•Preliminary results of s...
Long-term IgE immunological tolerance to peanut allergens: An alternative to Noon’s daily desensitization paradigm
Available online 27 September 2022, 104611Highlights•Long-term peanut allergen-specific IgE tolerance can be induced by pe...
Dampening of cytotoxic Innate lymphoid Cells: a new tumour immune escape mechanism in B cell non-Hodgkin's lymphoma
The role and regulation of innate immune cells is poorly understood in B-cell non-Hodgkin lymphoma (NHL). As natural kille...
Macrophages in intestinal fibrosis and regression
KeywordsMacrophagesGastrointestinal tractInflammationFibrosisInflammatory bowel diseaseAbbreviationsATX–LPAautotaxin–lysop...
Immunoglobulin A promotes IL-6 and IL-8 production, proliferation, and migration by the human bronchial smooth muscle cells
Available online 16 September 2022, 104612Highlights•Serum IgA bound to BSMCs and induced production of IL-6 and IL-8.•Ser...
A specific Leishmania infantum polyepitope vaccine triggers Th1-type immune response and protects against experimental visceral leishmaniasis
Available online 5 September 2022, 104592Highlights•Polyepitope vaccine induces CD4+ and CD8+ T multifunctional cells.•The...
Restoring tolerance to β-cells in Type 1 diabetes: Current and emerging strategies
Volume 380, October 2022, 104593Highlights•Targeted ablation of autoreactive T cells without broad immunosuppression.•Main...
Regulatory network of BLIMP1, IRF4, and XBP1 triad in plasmacytic differentiation and multiple myeloma pathogenesis
KeywordsAntibodyB cellsBLIMP1IRF4MalignancyMultiple myelomaPlasma cellsTranscriptional regulationXBP1AbbreviationsAICEAP-1...
Consequences and mechanisms of myelin debris uptake and processing by cells in the central nervous system
Available online 17 August 2022, 104591Highlights•Phagocytosis of debris generated from myelin sheath damage in CNS diseas...
The interferon regulatory factors, a double-edged sword, in the pathogenesis of type 1 diabetes
Available online 13 August 2022, 104590Highlights•1. Interferon regulatory factors (IRFs) are effector transcription facto...
Human dental pulp cells modulate CD8+ T cell proliferation and efficiently degrade extracellular ATP to adenosine in vitro
Available online 13 August 2022, 104589Highlights•Dental pulp cells (DPC) possess potent immunomodulatory capacity in vitr...
VISTA as a ligand downregulates LPS-mediated inflammation in macrophages and neutrophils
Available online 29 July 2022, 104581Highlights•VISTA is proposed to function both as an immune-modulatory ligand and rece...
Type 1 and 2 diabetes are associated with reduced natural killer cell cytotoxicity
Available online 18 July 2022, 104578Highlights•Type 1 and 2 diabetes are associated with reduced cytotoxic activity of NK...
Neutrophils, functions beyond host defense
Available online 19 July 2022, 104579Highlights•Neutrophils are heterogenetic populations with diverse functions.•Neutroph...
FGFR1 promotes tumor immune evasion via YAP-mediated PD-L1 expression upregulation in lung squamous cell carcinoma
Available online 9 July 2022, 104577Highlights•FGFR1 and PD-L1 co-expressed in human lung cancer samples from public datab...
Mesenchymal stem cell transplantation worsens intestinal inflammation and microenvironment in PI3Kγ-knockout mice
Available online 5 July 2022, 104573Highlights•1. PI3Kγ-/- mice showed less improvement than the wild-type mice after MSCs...
Neutrophils in the tumor microenvironment and their functional modulation by mesenchymal stromal cells
Available online 1 July 2022, 104576Highlights•The pro- and anti-tumor functions of neutrophils are reviewed.•Neutrophils ...
Methyl butyrate attenuates concanavalin A-induced autoimmune hepatitis by inhibiting Th1-cell activation and homing to the liver
Available online 24 June 2022, 104575Highlights•Methyl butyrate attenuates Con A-induced hepatitis and reduced the express...
In vitro 2D and 3D Cancer Models to Evaluate Compounds that Modulate Macrophage Polarization
Available online 23 June 2022, 104574Highlights•3D multicellular tumor spheroids are useful for discovery of novel immunot...
Mucosal-Associated Invariant T cells exhibit distinct functional signatures associated with protection against typhoid fever
Available online 20 June 2022, 104572Highlights•First demonstration of cytokine-secreting MAIT cell kinetics after human c...
“Near Cure” treatment of severe acute EAE in MIF-1-deficient female and male mice with a bifunctional MHCII-derived molecular construct
Available online 11 June 2022, 104561Highlights•MIF-1 contribution to severe acute EAE was stronger in females than in mal...
Immune system changes in those with hypertension when infected with SARS-CoV-2
Available online 9 June 2022, 104562Highlights•The Coronavirus Disease 2019 (COVID-19) outbreak has become an evolving glo...
Dectin-2 promotes house dust mite-skewed Th2 response through the activation of cDC2s
Available online 6 June 2022, 104558Highlights•The driving signal for Th2 polarization in asthma has been an enduring topi...
Dose-dependent immunomodulatory effects of metformin on human neonatal monocyte-derived macrophages
Available online 3 June 2022, 104557Highlights•• High-dose metformin promotes M1 pro-inflammatory macrophage polarization ...