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Maternal immune factors involved in the prevention or facilitation of neonatal bacterial infections
Maternal immune factors involved in the prevention or facilitation of neonatal bacterial infections
Newborns, whether born prematurely or at term, have a fully formed but naive immune system that must adapt to the extra-ut...
Loss of B1 and marginal zone B cells during ovarian cancer
Loss of B1 and marginal zone B cells during ovarian cancer
Immunity evolved not only to resist external challenges but also to serve in an internal, “housekeeping” function that ope...
Differential roles of regulatory T cells in Alzheimer's disease
Differential roles of regulatory T cells in Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the major cause of dementia. Progressive memory l...
Diacylglycerol kinase zeta deficiency attenuates papain-induced type 2 airway inflammation
Diacylglycerol kinase zeta deficiency attenuates papain-induced type 2 airway inflammation
Asthma is a chronic respiratory disease that is characterized by airway inflammation and non-specific bronchial hyperrespo...
Genetic deficiencies of both IL-4 receptor alpha chain and IL-10 trigger early onset of severe colitis in mice
Genetic deficiencies of both IL-4 receptor alpha chain and IL-10 trigger early onset of severe colitis in mice
Inflammatory bowel disease (IBD) is clinically classified as ulcerative colitis (UC) and Crohn’s disease (CD). Although th...
Antitumor activity of pegylated human interferon β as monotherapy or in combination with immune checkpoint inhibitors via tumor growth inhibition and dendritic cell activation
Antitumor activity of pegylated human interferon β as monotherapy or in combination with immune checkpoint inhibitors via tumor growth inhibition and dendritic cell activation
Immune checkpoint inhibitors (ICIs), such as anti-programmed cell death protein 1/anti-programmed cell death 1 ligand 1 (P...
A single-cell atlas of immunocytes in the spleen of a mouse model of Wiskott-Aldrich syndrome
A single-cell atlas of immunocytes in the spleen of a mouse model of Wiskott-Aldrich syndrome
Wiskott-Aldrich syndrome (WAS) is a rare disorder caused by an X-linked genetic mutation that causes immune deficiency and...
Dexamethasone alleviates pulmonary sarcoidosis by regulating the TGF-β/Smad3 signaling to promote Th17/Treg cell rebalance
Dexamethasone alleviates pulmonary sarcoidosis by regulating the TGF-β/Smad3 signaling to promote Th17/Treg cell rebalance
Sarcoidosis is a systemic inflammatory disease with significant morbidity and increased mortality and affects patients of ...
One-step shotgun approach for antigenic specific pMHCs capture stimulated CD8+ T cell activation and proliferation
One-step shotgun approach for antigenic specific pMHCs capture stimulated CD8+ T cell activation and proliferation
Due to the central role in immune surveillance, the antigen peptide hold tremendous promise for treatment modalities in ca...
Response to “Letter to the Editor: SMAC mimetics inhibit human T cell proliferation and fail to augment type 1 cytokine responses”
Response to “Letter to the Editor: SMAC mimetics inhibit human T cell proliferation and fail to augment type 1 cytokine responses”
We use cookies to help provide and enhance our service and tailor content and ads. By continuing you agree to the use of c...
Immunomodulatory action of synbiotic comprising of newly isolated lactic acid producing bacterial strains against allergic asthma in mice
Immunomodulatory action of synbiotic comprising of newly isolated lactic acid producing bacterial strains against allergic asthma in mice
Asthma is a heterogeneous respiratory syndrome of the lung airways characterized by intermittent episodes of wheezing and ...
Anti-CD19/CD8 bispecific T cell engager for the potential treatment of B cell malignancies
Anti-CD19/CD8 bispecific T cell engager for the potential treatment of B cell malignancies
As an important cause of mortality, cancer is listed as the first or second leading cause of death in 112 countries, accor...
Ro52/TRIM21 – From host defense to autoimmunity
Ro52/TRIM21 – From host defense to autoimmunity
Autoimmune diseases are a family represented by more than 100 cases of disorders. These illnesses affect about 3–5 % of th...
Variability of vaccine responsiveness in early life
Variability of vaccine responsiveness in early life
Vaccination is one of the most important interventions for public health, saving over 2.5 million lives each year worldwid...
Ferroptosis in the Post-Transplantation Inflammatory Response
Ferroptosis in the Post-Transplantation Inflammatory Response
Inflammation after solid organ transplantation is a key contributor to post-transplant complications. Post-transplant infl...
Early-immune development in asthma: a review of the literature
Early-immune development in asthma: a review of the literature
Asthma is the most common chronic disease in childhood, and according to the Global Asthma report, 14% of children worldwi...
ATM-AMPKα mediated LAG-3 expression suppresses T cell function in prostate cancer
ATM-AMPKα mediated LAG-3 expression suppresses T cell function in prostate cancer
LAG3Lymphocyte-activation gene 3CTLA4Cytotoxic T-lymphocyte-associated protein 4TIGITT cell Ig and ITIM domainTIM-3T cell ...
Letter to the Editor: SMAC mimetics inhibit human T cell proliferation and fail to augment type 1 cytokine responses
Letter to the Editor: SMAC mimetics inhibit human T cell proliferation and fail to augment type 1 cytokine responses
Available online 30 September 2023, 104772Author links open overlay panel, , Section snippetsTo the Editor2We read with gr...
Interactions of mesenchymal stromal/stem cells and immune cells following MSC-based therapeutic approaches in rheumatoid arthritis
Interactions of mesenchymal stromal/stem cells and immune cells following MSC-based therapeutic approaches in rheumatoid arthritis
Rheumatoid arthritis (RA) is a progressive and chronic autoimmune systemic inflammation involving multiple joints and the ...
Serum IgA augments adhesiveness of cultured lung microvascular endothelial cells and suppresses angiogenesis
Serum IgA augments adhesiveness of cultured lung microvascular endothelial cells and suppresses angiogenesis
Immunoglobulin A (IgA) is the most abundantly produced antibody on the mucosal surface and has an important immune functio...
Attenuated airways inflammation and remodeling in IL-37a and IL-37b transgenic mice with an ovalbumin-induced chronic asthma
Attenuated airways inflammation and remodeling in IL-37a and IL-37b transgenic mice with an ovalbumin-induced chronic asthma
Asthma is a common, chronic and heterogeneous respiratory disease affecting more than 300 million people worldwide[1]. In ...
Tandem CAR-T cells targeting MUC1 and PSCA combined with anti-PD-1 antibody exhibit potent preclinical activity against non-small cell lung cancer
Tandem CAR-T cells targeting MUC1 and PSCA combined with anti-PD-1 antibody exhibit potent preclinical activity against non-small cell lung cancer
Lung cancer is the second most popular tumor type all over the world, which has unexpectedly high morbidity and mortality ...
PD-1 negatively tunes macrophage immune activation by turning off JNK and STAT1 signaling: Exploited by Leishmania for its intra-macrophage survival
PD-1 negatively tunes macrophage immune activation by turning off JNK and STAT1 signaling: Exploited by Leishmania for its intra-macrophage survival
Programmed death-1 receptor or PD-1 is broadly expressed on diverse immune cells implying a broader role in a wide spectru...
A mAb to SIRPα Downregulates the Priming of Naive CD4+T Cell in Primary Immune Thrombocytopenia
A mAb to SIRPα Downregulates the Priming of Naive CD4+T Cell in Primary Immune Thrombocytopenia
Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by antiplatelet autoantibody-mediated platel...
Editorial: Processing, presentation, and recognition of T cell determinants: from molecular insights to clinical applications
Editorial: Processing, presentation, and recognition of T cell determinants: from molecular insights to clinical applications
Available online 9 August 2023, 104756Author links open overlay panelSection snippetsDeclaration of Competing InterestThe ...
HIF-1α regulates the expression of the non-conventional isoform of the cd5 gene in T cells under the hypoxic condition: A potential mechanism for CD5neg/low phenotype of infiltrating cells in solid tumors
The human immune system can recognize and eliminate the transformed cells from the body through tumor immunosurveillance [...
HIF-1α regulates the expression of the non-conventional isoform of the cd5 gene in T cells under the hypoxic condition: a potential mechanism for CD5neg/low phenotype of infiltrating cells in solid tumors
The human immune system can recognize and eliminate the transformed cells from the body through tumor immunosurveillance [...
Phloretin suppresses intestinal inflammation and maintained epithelial tight junction integrity by modulating cytokines secretion in in vitro model of gut inflammation
Ulcerative colitis is a type chronic (IBD) Inflammatory Bowel Disease and its pathology is linked to the intestinal epithe...
Piperine Suppresses Inflammatory Fibroblast-like Synoviocytes Derived from Rheumatoid Arthritis Patients via NF-κB Inhibition
Rheumatoid arthritis (RA) is one of the most prevalent and systemic autoimmune disorders with an unknown etiology. This in...
Haploinsufficiency of A20 caused by a novel pathogenic missense variant of TNFAIP3 and successfully treated with anti-TNF and immunosuppressive therapies
Protein A20, encoded by tumor necrosis factor alpha induced protein 3 (TNFAIP3), inhibits inflammatory and immune response...
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