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Autoimmune susceptible HLA class II motifs facilitate the presentation of modified neo-epitopes to potentially autoreactive T cells
Human leukocyte antigen (HLA) class II genes are found in the three most polymorphic loci, and are associated with more di...
Downregulation of HHLA2 inhibits ovarian cancer progression via the NF-κB signaling pathway and suppresses the expression of CA9
HHLA2 has been recently demonstrated to play multifaceted roles in several types of cancers. However, its underlying mecha...
Paeonol attenuates Substance P-induced urticaria by inhibiting Src kinase phosphorylation in mast cells
Mast cells are one of the most important cells which is responsible for allergic reactions. Antigen with its specific IgE ...
Mocravimod, a S1P receptor modulator, increases T cell counts in bone marrow biopsies from patients undergoing allogeneic hematopoietic stem cell transplantation
Allogeneic hematopoietic cell transplantation (allo-HCT) is often the only curative treatment for patients with hematologi...
IFN-β ACTIVATES CYTOTOXIC FUNCTION OF HUMAN NATURAL KILLER CELLS TOWARD IL-27 AND POLY(I:C) STIMULATED PC3 AND DU145 CELLS
Lymphocytes play an important role in cancer immunosurveillance. Unlike T cells, the innate lymphocytic natural killer (NK...
Aberrant pro-inflammatory responses of CD20+ T cells in experimental arthritis
Autoimmune conditions such as rheumatoid arthritis (RA) are characterized by lymphocytic tissue infiltrates containing abe...
Analysis of the different subpeptidomes presented by the HLA class I molecules of the B7 supertype
MHC-I molecules of the HLA-B7 supertype preferentially bind peptides with proline at position 2. HLA-B*51:01 and B*51:08 p...
MAX transcriptionally enhances PD-L1 to inhibit CD8+ T cell-mediated killing of lung adenocarcinoma cells
Lung cancer is one of the most common malignancies worldwide and poses a serious threat to human health. Non-small cell lu...
Expression of SARS-CoV-2 receptor angiotensin-converting enzyme 2 by activating protein-1 in human mast cells
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection activates mast cells and induces a cytokine storm, ...
Muscone promotes functional recovery by facilitating microglia polarization into M2 phenotype through PPAR-γ pathway after ischemic stroke
Ischemic stroke is one of the leading causes of adult death and long-term disability , . When ischemic stroke happen...
Epigenetic regulation of iNKT2 cell adoptive therapy on the imbalance of iNKT cell subsets in thymus of RA mice
Epigenetic regulation affects the development and differentiation of iNKT cells. Our previous study found that the number ...
Innovation and Clinical Progress in Oral Tolerance
Available online 26 February 2023, 104695Author links open overlay panel, , Section snippetsDeclaration of Competing Inter...
Alpha-galactosylceramide as adjuvant induces protective cell-mediated immunity against Leishmania mexicana infection in vaccinated BALB/c mice
Leishmaniasis constitutes a globally widespread group of neglected tropical diseases (NTDs) caused by intracellular parasi...
Fine particulate matter (PM2.5) induces inhibitory memory alveolar macrophages through the AhR/IL-33 pathway
Chronic obstructive pulmonary disease (COPD) is a devastating lung disease with high morbidity, mortality, as well as pers...
A Clinical Focus on Oral Tolerance in the Development, Prevention, and Management of Food Allergy
Food allergy impacts approximately 10% of adults and 8% of children in the United States based on a survey from 2018  w...
Vaccination against SARS-CoV-2 Using Extracellular Blebs Derived from Spike Protein-Expressing Dendritic Cells
COVID-19 has caused significant morbidity and mortality worldwide but also accelerated the clinical use of emerging vaccin...
Downregulation of a tumor suppressor gene LKB1 in lung transplantation as a biomarker for chronic murine lung allograft rejection
Lung transplantation (LTx) is the only life-extending option for patients with end-stage lung diseases. Approximately half...
Weighted gene co-expression network-based identification of genetic effect of mRNA vaccination and previous infection on SARS-CoV-2 infection
KeywordsCOVID-19SARS-CoV-2 Omicron infectionBNT162b2 mRNA vaccineWGCNALILRB2MHC class I protein bindingData availabilityPu...
Inhibition of Hexokinase 2 with 3-BrPA Promotes MDSCs Differentiation and Immunosuppressive function
Keywordshexokinase 23-bromopyruvic acidmyeloid-derived suppressor cellsallogeneic heart transplantSTAT3cellular therapyAbb...
Biochemical detection system for intermediates of endogenous antigen and elucidation of the role of molecular chaperones
The importance of vaccines has renewed attention in part due to the global pandemic of SARS-CoV-2. Vaccine-induced effecti...
Damage-induced NAD Release Activates Intestinal CD4+ and CD8+ T cell via P2X7R Signaling
Postoperative ileus (POI) is a well-known complication of abdominal surgery. Patients with POI usually experience nausea, ...
Lnc-17Rik Promotes the Immunosuppressive Function of Myeloid-Derived Suppressive Cells in Esophageal Cancer
Myeloid-derived suppressor cells (MDSCs) are a population of immature bone marrow cells that accumulate in large numbers i...
Suppression of anti-drug antibody formation against coagulation factor VIII by oral delivery of anti-CD3 monoclonal antibody in hemophilia A mice
Hemophilia A (affecting 1 in 5000 male births) is inherited as an X-linked recessive genetic disorder, resulting in a defi...
SMAC mimetics inhibit human T cell proliferation and fail to augment type 1 cytokine responses
In the past two decades, the number of targeted therapies for cancer treatment has grown exponentially. SMAC (second mitoc...
Retraction notice to “NFKB1 mediates Th1/Th17 activation in the pathogenesis of psoriasis” [Cell. Immunol. 331 (2018) 16–21]
Available online 11 January 2023, 104662Author links open overlay panelFushengZhouab1ZhengweiZhuab1JinpingGaoab1ChaoYangab...
Soluble CD25 imposes a low-zone IL-2 signaling environment that favors competitive outgrowth of antigen-experienced CD25high regulatory and memory T cells
This study focused on soluble (s)CD25-mediated regulation of IL-2 signaling in murine and human CD4+ T cells. Recombinant ...
Activated neutrophils inhibit chemotactic migration of activated T lymphocytes to CXCL11 by multiple mechanisms
Accumulation of T lymphocytes and neutrophils shows inversed accosiation with the prognosis of cancer patients, suggesting...
Hsp65-producing Lactococcus lactis inhibits experimental autoimmune encephalomyelitis by preventing cell migration into spinal cord
Multiple sclerosis (MS) is an immune mediated disease that affects the central nervous system of genetically predisposed i...
Phosphatidylserine-mediated Oral Tolerance
Available online 24 December 2022, 104660Author links open overlay panelAbstractPhosphatidylserine (PS) is an anionic phos...
Pharmacological suppression of NLRP3 inflammasome attenuated the development of autoimmune thyroiditis
Autoimmune thyroiditis (AIT) is a well-known organ-specific autoimmune disease. Hashimoto’s thyroiditis is a prevalent sub...
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