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Emerging roles of extracellular vesicles in normal and malignant hematopoiesis
Hematologic malignancies (HMs) represent a heterogeneous group of hematopoietic neoplasms commonly characterized by the a...
Moving beyond the T cell synapse for combination neoadjuvant immunotherapy in head and neck cancer
Locally advanced, HPV-unrelated HNSCC is associated with a high rate of therapeutic resistance following standard-of-care...
Imaging infection amid inflammation
Published in Volume 132, Issue 18 on September 15, 2022 J Clin Invest. 2022;132(18):e162885. https://doi.org/10.1172/J...
Imaging sensitive and drug-resistant bacterial infection with [11C]-trimethoprim
Clinical MedicineInfectious disease Open Access | 10.1172/JCI156679 Iris K. Lee,1,2 Daniel ...
Von Hippel–Lindau disease: insights into oxygen sensing, protein degradation, and cancer
My mentor, the late David M. Livingston (139), taught me and his other mentees that every good experiment starts with the...
A world without tuberculosis: moving from imagination to reality
The treatment of individuals with LTBI with a 3-month, weekly treatment with isoniazid and rifapentine (3HP) has been pre...
A conversation with Vishva Dixit
On any given day, over 50 billion of the cells in your body will die. The question of how we live while our cells are con...
Functional cure of hepatitis B requires silencing covalently closed circular and integrated hepatitis B virus DNA
Hepatitis B virus (HBV) is a small DNA virus that infects the liver. Its entry into hepatocytes is facilitated by the sod...
Integrated hepatitis B virus DNA maintains surface antigen production during antiviral treatment
A multiplex ddPCR assay for iDNA-derived transcripts. We developed a discriminatory assay exploiting the shared cccDNA-de...
Lessons from a large-scale COVID-19 vaccine trial
Vaccine- or natural infection-acquired immunity to respiratory viruses declines over time (9). Therefore, it is increasin...
Goblet cells need some stress
Mucus is vital for the protection of epithelial surfaces in the body. It assists in numerous functions to maintain homeos...
Tetracyclines: four rings to rule infections through resistance and disease tolerance
In this issue of the JCI, Mottis and colleagues take these observations further to demonstrate that tetracyclines also in...
Tetracycline-induced mitohormesis mediates disease tolerance against influenza
To characterize the MSR induced by Tets in vivo, we administered Dox at 500 mg/kg/day (mpkd) in the drinking water to 9-w...
FcγRIIB regulates autoantibody responses by limiting marginal zone B cell activation
Increased spontaneous autoantibody IgG3 responses in Fcgr2b-cKO mice. We first characterized the spontaneous autoantibody...