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Frameshift mutation spectra overlap between constitutional mismatch repair deficiency tumors and Lynch syndrome tumors
Research LetterOncology Open Access | 10.1172/JCI185999 Yurong Song, Ryan N. Baugher, ...
Neutrophil-specific Shp1 loss results in lethal pulmonary hemorrhage in mouse models of acute lung injury
Sex as a biological variable. Our study examined male and female animals, and similar findings are reported for both sexe...
Interleukin 10 drives Staphylococcus aureus imprinting and vaccine failure in murine models via antibody glycosylation
Human exposure to S. aureus triggers the development of immunity, imprinting an adaptive immune response that is lacking ...
Pathobiont-driven antibody sialylation through IL-10 undermines vaccination
Research ArticleImmunologyInfectious disease Open Access | 10.1172/JCI179563 Chih-Ming Tsai,1...
Disrupted uromodulin trafficking is rescued by targeting TMED cargo receptors
Research ArticleNephrology Open Access | 10.1172/JCI180347 Silvana Bazua-Valenti,1,2,3 Ma...
DNA-PK inhibition enhances neoantigen diversity and increases T cell responses to immunoresistant tumors
Combination DNA-PK inhibition plus immune adjuvants drive melanoma regression via a CD8+ T cell–dependent mechanism. We p...
Attenuated kidney oxidative metabolism in young adults with type 1 diabetes
Clinical MedicineEndocrinologyMetabolism Open Access | 10.1172/JCI183984 Ye Ji Choi,1,2 G...
Immune-molecular interactions in high-grade serous ovarian cancer distinguish long-term survivors
BACKGROUND Despite an overall poor prognosis, about 15% of patients with advanced-stage tubo-ovarian high-grade serous ca...
Balancing immune response: SHP1 controls neutrophil activation in inflamed lungs
Src homology region 2 domain-containing phosphatase-1 (SHP1), a cytosolic tyrosine phosphatase, emerges as a crucial nega...
Evi1 governs Kdm6b-mediated histone demethylation to regulate the Laptm4b-driven mTOR pathway in hematopoietic progenitor cells
Research ArticleHematology Open Access | 10.1172/JCI173403 Qiong Wu,1,2 Chunjie Yu,2 ...
Breast cancers that disseminate to bone marrow acquire aggressive phenotypes through CX43-related tumor-stroma tunnels
Research ArticleOncology Open Access | 10.1172/JCI170953 Saptarshi Sinha,1 Brennan W. Cal...
Nicotinamide and pyridoxine stimulate muscle stem cell expansion and enhance regenerative capacity during aging
Research ArticleMuscle biologyStem cells Open Access | 10.1172/JCI163648 Sara Ancel,1,2 J...
MOGAT3-mediated DAG accumulation drives acquired resistance to anti-BRAF/anti-EGFR therapy in BRAFV600E-mutant metastatic colorectal cancer
Upregulated lipid metabolism linked to encorafenib/cetuximab resistance in BRAFV600E-mutant mCRC. To investigate the pote...
Endothelial BMAL1 decline during aging leads to bone loss by destabilizing extracellular fibrillin-1
The alleviation of senile bone loss can be achieved by preventing the decline of BMAL1 induced by aging. BMAL1 is a criti...
Activation of Gs signaling in mouse enteroendocrine K cells greatly improves obesity- and diabetes-related metabolic deficits
Generation and functional characterization of K-GsD mice. To generate mutant mice that express the GsD designer receptor ...
Sialylated glycoproteins suppress immune cell killing by binding to Siglec-7 and Siglec-9 in prostate cancer
Research ArticleOncology Open Access | 10.1172/JCI180282 Ru M. Wen,1 Jessica C. Stark,2,3...
Distinct mechanisms drive divergent phenotypes in hypertrophic and dilated cardiomyopathy–associated TPM1 variants
Further information can be found in Supplemental Results. Hyper- and hypocontractility observed in E62Q and E54K EHTs. Th...
The muscle stem cell case of Benjamin Button: rejuvenating muscle regenerative capacity through nutraceuticals
With their promising results, Ancel and colleagues (3) raise compelling questions for the field moving forward. Notably n...
Beyond ketosis: the search for the mechanism underlying SGLT2-inhibitor benefit continues
Without question, circulating ketones are readily used by the healthy heart and preferentially used by the failing myocar...
SGLT2 inhibition alters substrate utilization and mitochondrial redox in healthy and failing rat hearts
Research ArticleCardiologyMetabolism Open Access | 10.1172/JCI176708 Leigh Goedeke,1,2,3 ...
Delayed reinforcement of costimulation improves the efficacy of mRNA vaccines in mice
Sex as a biological variable. Our study examined male and female animals, and similar findings are reported for both sexe...
Dysregulated Treg repair responses lead to chronic rejection after heart transplantation
Research ArticleImmunologyTransplantation Open Access | 10.1172/JCI173593 Jordan J.P. Warunek...
YTHDF1 loss in dendritic cells potentiates radiation-induced antitumor immunity via STING-dependent type I IFN production
Research ArticleImmunologyOncology Open Access | 10.1172/JCI181612 Chuangyu Wen,1,2 Liang...
Reduced thymic IL-4 impairs negative T cell selection in nonobese diabetic mice
NOD HR+ETP fate decision is biased toward the T cell lineage. Recently a new subset of ETPs was discovered whose potentia...
Sex, cells, and metabolism: Androgens temper Th17-mediated immunity
The study by Chowdhury and colleagues provides compelling evidence that AR activity plays a critical role in regulating T...
Combined HDAC8 and checkpoint kinase inhibition induces tumor-selective synthetic lethality in preclinical models
Research ArticleCell biologyTherapeutics Open Access | 10.1172/JCI165448 Ting-Yu Chang,1 ...
FoxO1/Rictor axis induces a nongenetic adaptation to ibrutinib via Akt activation in chronic lymphocytic leukemia
Research ArticleHematologyOncology Open Access | 10.1172/JCI173770 Laura Ondrisova,1,2 Va...
EMC3 regulates trafficking and pulmonary toxicity of the SFTPCI73T mutation associated with interstitial lung disease
Research ArticleCell biologyPulmonology Open Access | 10.1172/JCI173861 Xiaofang Tang,1,2 ...
The Nr4a family regulates intrahepatic Treg proliferation and liver fibrosis in MASLD models
Expression of the Nr4a family is upregulated in hepatic T cells from MASH mice. To investigate the function of the Nr4a f...
Transcription factor KROX20 marks epithelial stem cell ancestors for hair follicle formation
Research ArticleDevelopmentStem cells Open Access | 10.1172/JCI180160 Elnaz Ghotbi,1 Edem...
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