SCI时时刷

search
+
AlphaFold developers Demis Hassabis and John Jumper share the 2023 Albert Lasker Basic Medical Research Award
To achieve this success, they developed a whole new AI architecture, recognizing that they were predicting protein struct...
Optical coherence tomography: when a picture is worth a million words
The vast majority of diseases that cause catastrophic loss of vision do so as a result of vascular changes leading to hem...
Loss of Mtm1 causes cholestatic liver disease in a model of X-linked myotubular myopathy
Research ArticleHepatologyMuscle biology Open Access | 10.1172/JCI166275 Sophie Karolczak,1,2 ...
Tau fibrils induce glial inflammation and neuropathology via TLR2 in Alzheimer’s disease–related mouse models
Activation of microglia by fibrillar tau. Human full-length tau (2N4R) monomers were subjected to in vitro fibrillation i...
The predominant PAR4 variant in individuals of African ancestry worsens murine and human stroke outcomes
Research ArticleHematologyNeuroscience Open Access | 10.1172/JCI169608 Frederik Denorme,1,2 ...
Cell-free, high-density lipoprotein–specific phospholipid efflux assay predicts incident cardiovascular disease
Clinical MedicineVascular biology Open Access | 10.1172/JCI165370 Masaki Sato,1,2,3 Edward ...
Antibody-drug conjugates in breast cancer: overcoming resistance and boosting immune response
Despite the clinical impact of ADCs, a portion of patients have de novo or primary resistance to ADCs, and another subset...
Adding robustness to rigor and reproducibility for the three Rs of improving translational medical research
Therapeutic candidates tested in clinical trials primarily originate from results gathered using preclinical models. Howe...
Mouse model hints at pharmacogenomic strategies for stroke treatment in patients possessing a risk variant
Published in Volume 133, Issue 18 on September 15, 2023 J Clin Invest. 2023;133(18):e173932. https://doi.org/10.1172/J...
Scaling the EVERREST of severe, early-onset fetal growth restriction
For technical and practical reasons, fetuses are diagnosed as growth restricted when their estimated fetal weight (EFW) i...
Genetic modification of inflammation- and clonal hematopoiesis–associated cardiovascular risk
Research ArticleCardiologyGenetics Open Access | 10.1172/JCI168597 Zhi Yu,1,2 Trevor P. Fid...
Maternal PlGF and umbilical Dopplers predict pregnancy outcomes at diagnosis of early-onset fetal growth restriction
Clinical MedicineReproductive biology Open Access | 10.1172/JCI169199 Rebecca Spencer,1,2 K...
Nucleus accumbens D1/D2 circuits control opioid withdrawal symptoms in mice
Research ArticleNeuroscience Open Access | 10.1172/JCI163266 Yongsheng Zhu,1 Kejia Wang,2 ...
SMAD4 maintains the fluid shear stress set point to protect against arterial-venous malformations
Smad4 signaling maintains the shear stress set point–mediated EC responses. In developing vasculature, AVMs form in regio...
Allosteric modulator potentiates β2AR agonist–promoted bronchoprotection in asthma models
Materials. Compound-6 was synthesized as previously described (21). With the exception of BI-167107, which was synthesize...
Beyond epithelial damage: vascular and endothelial contributions to idiopathic pulmonary fibrosis
The key vascular signaling pathways that promote fibrogenesis involve NO or GPCR signaling via cAMP or cGMP to promote tr...
PJA1 mediates the effects of astrocytic GPR30 on learning and memory in female mice
Research ArticleInflammationNeuroscience Open Access | 10.1172/JCI165812 Xinshang Wang,1 Yo...
Targeting collagen XVIII improves the efficiency of ErbB inhibitors in breast cancer models
Research ArticleOncology Open Access | 10.1172/JCI159181 Raman Devarajan,1,2,3 Valerio Izzi...
Cardiac macrophages and emerging roles for their metabolism after myocardial infarction
Antiinflammatory macrophage polarization is often correlated with oxidative mitochondrial metabolism that is distinct fro...
Tumors produce glucocorticoids by metabolite recycling, not synthesis, and activate Tregs to promote growth
Cancer cells generate glucocorticoids by recycling inactive metabolites. Active glucocorticoids are synthesized de novo f...
Noncanonical CDK4 signaling rescues diabetes in a mouse model by promoting β cell differentiation
Homozygous replacement of WT Cdk4 with Cdk4-R24C rescued diabetes in Irs2–/– male mice. To test whether activating CDK4 r...
Tumors recycle glucocorticoids to drive Treg-mediated immunosuppression
In this issue of the JCI, Taves, Otsuka, and colleagues show that murine tumor cell lines express the enzyme 11β-HSD1 and...
No evidence of durable trained immunity after two doses of adenovirus-vectored or mRNA COVID-19 vaccines
Research LetterCOVID-19Vaccines Open Access | 10.1172/JCI171742 Natalie E. Stevens,1,2 Fear...
Primary sclerosing cholangitis and the path to translation
In recent years, several studies have focused on defining gut microbial signatures and metabolites in PSC. These findings...
The emerging importance of lymphatics in health and disease: an NIH workshop report
Lymphatic abnormalities play a key role in many pathological processes (Figure 3). Here, we highlight a few disease condi...
SAP30 promotes breast tumor progression by bridging the transcriptional corepressor SIN3 complex and MLL1
SAP30 is upregulated in human breast tumors and correlates with poor survival of patients. To study the clinical relevanc...
Blood-derived lysophospholipid sustains hepatic phospholipids and fat storage necessary for hepatoprotection in overnutrition
Mfsd2a is an early response gene during overnutrition. It has been previously shown that Mfsd2a is expressed specifically...
Autotaxin suppresses cytotoxic T cells via LPAR5 to promote anti–PD-1 resistance in non–small cell lung cancer
Generation of tumor models with intrinsic resistance to anti–PD-(L)1 blockade. To examine PD-1 blockade resistance, we cr...
Linked CD4+/CD8+ T cell neoantigen vaccination overcomes immune checkpoint blockade resistance and enables tumor regression
Cancer cell stemness and intrinsic resistance mechanisms. Squamous cell carcinoma VII (SCC VII) is a spontaneously arisin...
Pulmonary inflammation and fibroblast immunoregulation: from bench to bedside
Phenotypic heterogeneity of lung fibroblasts. Fibroblasts in the respiratory tract represent a diverse group of cells wit...
阅读更多
format_indent_increase