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Protein aggregates containing wild-type and mutant NOTCH3 are major drivers of arterial pathology in CADASIL
Conceptualization of the experimental strategy. As a representative mutation commonly found in CADASIL patients, we studi...
A BMP-controlled metabolic/epigenetic signaling cascade directs midfacial morphogenesis
Elevated BMP/Smad signaling in CNCCs elicits drastic midline facial defects. Midfacial morphogenesis depends upon the gro...
Capillary malformations
Canonical and noncanonical signaling. GTP-bound Gαq can exert canonical signaling through phospholipase C-β (PLCβ) (71). ...
Oncotherapy resistance explained by Darwinian and Lamarckian models
Selection by chemotherapy or CAR-T for malignant B cells containing inactivating mutations and/or deletions of key apopto...
VHL governs m6A modification and PIK3R3 mRNA stability in clear cell renal cell carcinomas
N6-methyladenosine (m6A) represents one of the most prevalent RNA chemical modifications in mRNA that substantially impac...
Central conducting lymphatic anomaly: from bench to bedside
Investigation of the mechanisms underlying CCLA and validation of candidate genes hinges on effective in vitro and in viv...
Major breakthroughs in hematopoietic stem cell transplantation and future challenges in clinical implementation
Hematopoietic stem cell transplantation (HCT) is a curative therapy for many malignant and nonmalignant hematologic disea...
Evolution of nasal and olfactory infection characteristics of SARS-CoV-2 variants
WA1 strain primarily targets human olfactory neuroepithelium. The human olfactory mucosa is located in the superior part ...
Granulocytic myeloid-derived suppressor cell activity during biofilm infection is regulated by a glycolysis/HIF1a axis
scRNA-Seq identifies prominent glycolytic and hypoxia signatures in granulocytes throughout the course of PJI. Prior work...
Bisphosphonates for osteoporosis: from bench to clinic
With increased usage, it was soon evident that the decrease in bone fracture incidence induced by bisphosphonates was dis...
Tumor-educated Gr1+CD11b+ cells drive breast cancer metastasis via OSM/IL-6/JAK–induced cancer cell plasticity
A SCA1+ tumor cell population is enriched during tumor progression and has higher in vivo metastatic capacity. To investi...
Single-cell sequencing shows mosaic aneuploidy in most human embryos
In this issue of the JCI, Chavli, Klaasen, and colleagues (9) provide insight that profoundly affects the debate on the a...
PD-1 or CTLA-4 blockade promotes CD86-driven Treg responses upon radiotherapy of lymphocyte-depleted cancer in mice
The RT response is deficient in T cell–depleted human tumor types. To identify how the tumor immune cell composition infl...
Lymphatic malformations: mechanistic insights and evolving therapeutic frontiers
Patients with LM have until recently been treated solely by nonpharmacological approaches, such as surgical resection, sc...
Just a spoonful of metformin helps the medicine go down
The treatment regimen developed by Duchatel, Jackson, and colleagues exemplifies this approach. Their strategy included t...