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The ubiquitin ligase TRIM21 regulates mutant p53 accumulation and gain of function in cancer
TRIM21 is a mutp53-interacting protein. To investigate the mechanism underlying mutp53 accumulation in cancer, we screene...
A terpene nucleoside from M. tuberculosis induces lysosomal lipid storage in foamy macrophages
Research ArticleInfectious diseaseMicrobiology Open Access | 10.1172/JCI161944 Melissa Bedard,1...
Monogenic disease analysis establishes that fetal insulin accounts for half of human fetal growth
In utero growth restraint due to absent fetal insulin secretion did not persist postnatally. In individuals with loss-of-...
Glia in FTLD-GRN: from supporting cast to leading role
While hemizygous Grn (Grn+/–) mice display only mild behavioral phenotypes and no neuropathologic abnormalities, Grn–/– m...
Targeting pleckstrin-2/Akt signaling reduces proliferation in myeloproliferative neoplasm models
Research ArticleHematologyOncology Open Access | 10.1172/JCI159638 Xu Han,1,2 Yang Mei,1,2 ...
User-friendly bioorthogonal reactions click to explore glycan functions in complex biological systems
Besides DNA, RNA, proteins, and lipids, the other major macromolecular components of living systems are carbohydrates (her...
UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis
Published in Volume 133, Issue 6 on March 15, 2023 J Clin Invest. 2023;133(6):e169986. https://doi.org/10.1172/JCI1699...
SLAMF7 regulates the inflammatory response in macrophages during polymicrobial sepsis
SLAMF7 expression is strongly related to sepsis. To evaluate the inflammatory mediators involved in TLR signaling during ...
Preclinical and clinical evidence for suppression of alcohol intake by apremilast
Research ArticleClinical trialsNeuroscience Open Access | 10.1172/JCI159103 Kolter B. Grigsby,1...
HMGA1 induces FGF19 to drive pancreatic carcinogenesis and stroma formation
Research ArticleOncology Open Access | 10.1172/JCI151601 Lionel Chia,1,2 Bowen Wang,2,3 ...
PP2Ac/STRN4 negatively regulates STING-type I IFN signaling in tumor-associated macrophages
Research ArticleImmunologyOncology Open Access | 10.1172/JCI162139 Winson S. Ho,1 Isha Mond...
The immunometabolite itaconate stimulates OXGR1 to promote mucociliary clearance during the pulmonary innate immune response
Research ArticleMetabolism Open Access | 10.1172/JCI160463 Yi-Rong Zeng,1 Jun-Bin Song,1 ...
Clonally expanded HIV-1 proviruses with 5′-leader defects can give rise to nonsuppressible residual viremia
Clinical MedicineAIDS/HIV Open Access | 10.1172/JCI165245 Jennifer A. White,1 Fengting Wu,1...
Astroglial toxicity promotes synaptic degeneration in the thalamocortical circuit in frontotemporal dementia with GRN mutations
Parallel glial pathology in Grn–/– and FTLD-GRN brains. To investigate the impacts of GRN mutations in the thalamocortica...
The fat is in the lysosome: how Mycobacterium tuberculosis tricks macrophages into storing lipids
In this issue of the JCI, Bedard et al. (16) shine a light on these processes. By using correlative light and electron mi...
Th2-skewed T cells correlate with B cell response to α-Gal and tick antigens in α-Gal syndrome
In total, 50 patients with AGS and 19 individuals without AGS (controls) were enrolled in the study. All patients had IgE...
SARS-CoV-2 variants resistant to monoclonal antibodies in immunocompromised patients is a public health concern
In this issue of the JCI, Gupta et al. (1) report the systematic emergence of SARS-CoV-2 variants expressing Spike mutati...
Single-cell characterization of anti–LAG-3 and anti–PD-1 combination treatment in patients with melanoma
Clinical MedicineImmunologyOncology Open Access | 10.1172/JCI164809 Jani Huuhtanen,1,2,3,4 ...
Connexin hemichannels as candidate targets for cardioprotective and anti-arrhythmic treatments
Due to the crucial role of Cx43 in the body and the heart in particular, mutants have a high risk of being eliminated at ...
Nonsuppressible viremia during HIV-1 therapy meets molecular virology
We now know that it is possible for proviruses to produce virus particles with viral RNA even when the MSD site is gone. ...
IL-1β suppression of VE-cadherin transcription underlies sepsis-induced inflammatory lung injury
Published in Volume 133, Issue 5 on March 1, 2023 J Clin Invest. 2023;133(5):e169500. https://doi.org/10.1172/JCI16950...
Discovering chronic pain treatments: better animal models might help us get there
Traditionally, modeling pain conditions in animals — usually rodents — involves the use of chemical or surgical intervent...
Distinct early cellular kinetics in participants protected against colonization upon Bordetella pertussis challenge
Ten of 15 participants colonized after challenge with B1917 strain. Samples from 15 participants were collected between N...
Antigen specificity and cross-reactivity drive functionally diverse anti–Aspergillus fumigatus T cell responses in cystic fibrosis
Clinical MedicineImmunologyPulmonology Open Access | 10.1172/JCI161593 Carsten Schwarz,1 Pa...
Highly synchronized cortical circuit dynamics mediate spontaneous pain in mice
Research ArticleNeuroscienceTherapeutics Open Access | 10.1172/JCI166408 Weihua Ding,1 Luka...
BosR and PlzA reciprocally regulate RpoS function to sustain Borrelia burgdorferi in ticks and mammals
Development of capture-based enrichment RNA-Seq to delineate RpoS-regulated genes in engorged nymphal ticks Using compara...
Conversion of CD73hiFR4hi anergic T cells to IFN-γ–producing effector cells disrupts established immune tolerance
1Nephrology, Duke University Medical Center, Durham, North Carolina, USA.2Organ Transplantation, First Affiliated Hospi...
A TRPV4-dependent neuroimmune axis in the spinal cord promotes neuropathic pain
Research ArticleNeuroscience Open Access | 10.1172/JCI161507 Xueming Hu,1 Lixia Du,1 Sh...
A seed sequence variant in miR-145-5p causes multisystem smooth muscle dysfunction syndrome
LetterResearch LetterVascular biology Open Access | 10.1172/JCI166497 Christian Lacks Lino Card...
SGLT2 inhibitors mitigate kidney tubular metabolic and mTORC1 perturbations in youth-onset type 2 diabetes
Research ArticleMetabolismNephrology Open Access | 10.1172/JCI164486 Jennifer A. Schaub,1 F...
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