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A conversation with Stanley Prusiner
The discovery that a protein alone could be infectious, proposed by Stanley Prusiner of the University of California San ...
Antigen specificities and proviral integration sites differ in HIV-infected cells by timing of antiretroviral treatment initiation
Research ArticleAIDS/HIVVirology Open Access | 10.1172/JCI159569 Jaimy Joy,1 Ana Gervassi,1...
Circadian disruption, clock genes, and metabolic health
In vivo animal models of circadian rhythms. Early investigations into circadian rhythms relied on easily measured physiol...
VCP activator reverses nuclear proteostasis defects and enhances TDP-43 aggregate clearance in multisystem proteinopathy models
Ubiquitinated intranuclear inclusions in FTLD-TDP type D, IBM, and Paget’s disease of bone. Given the diverse tissues tha...
Neutrophil-mediated hypoxia drives pathogenic CD8+ T cell responses in cutaneous leishmaniasis
CD8+ T cells express GzmB in leishmanial lesions but not in the dLNs. Cytotoxic CD8 T cells are pathogenic in cutaneous l...
Spatial and functional targeting of intratumoral Tregs reverses CD8+ T cell exhaustion and promotes cancer immunotherapy
Research ArticleImmunologyOncology Open Access | 10.1172/JCI180080 Lei Zhou,1,2 Maria Veleg...
CAR+ extracellular vesicles predict ICANS in patients with B cell lymphomas treated with CD19-directed CAR T cells
Clinical MedicineHematologyImmunology Open Access | 10.1172/JCI173096 Gianluca Storci,1 Fra...
Subthreshold activation of the melanocortin system causes generalized sensitization to anorectic agents in mice
Research ArticleMetabolism Open Access | 10.1172/JCI178250 Naima S. Dahir,1,2 Yijun Gui,1,3...
Multiscale modeling uncovers 7q11.23 copy number variation–dependent changes in ribosomal biogenesis and neuronal maturation and excitability
Research ArticleNeuroscienceStem cells Open Access | 10.1172/JCI168982 Marija Mihailovich,1,2 ...
Loss-of-function mutations of the TIE1 receptor tyrosine kinase cause late-onset primary lymphedema
Research ArticleGeneticsVascular biology Open Access | 10.1172/JCI173586 Pascal Brouillard,1 ...
Interruption of KLF5 acetylation promotes PTEN-deficient prostate cancer progression by reprogramming cancer-associated fibroblasts
Research ArticleOncology Open Access | 10.1172/JCI175949 Baotong Zhang,1,2,3 Mingcheng Liu,...
Molecular analysis of primary and metastatic sites in patients with renal cell carcinoma
Clinical MedicineOncology Open Access | 10.1172/JCI176230 Shuchi Gulati,1 Pedro C. Barata,2...
Targeting apoptotic pathways for cancer therapy
Review Open Access | 10.1172/JCI179570 Xiaobing Tian,1,2,3,4 Praveen R. Srinivasan,1,2,3,4 ...
Elevated WTAP promotes hyperinflammation by increasing m6A modification in inflammatory disease models
Hyperinflammation is accompanied by elevated WTAP levels in many inflammatory diseases. To reveal how m6A modification pl...
BRCAness, DNA gaps, and gain and loss of PARP inhibitor–induced synthetic lethality
When BRCA-deficient cells become PARPi resistant, their defects in HR, fork protection, and gap protection are often part...
Beneficial islet inflammation in health depends on pericytic TLR/MyD88 signaling
Pancreatic pericytes of healthy humans and mice express cytokines. We hypothesized that islet inflammation, which is fund...
What happens to the brain during pregnancy?
University of Minnesota, Minneapolis, Minnesota, USA. Find articles by Maxwell, A. in: JCI | ...
Illuminating maternal sepsis: a call for improved recognition and prevention
1Medical Scientist Training Program, Medical University of South Carolina, Charleston, South Carolina, USA.2Lexington M...
Missing microbiomes: global underrepresentation restricts who research will benefit
Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA. Find articles by Blake, K....
The (unresolved) antibody paradox
Leeds Institute of Medical Research, University of Leeds, Leeds, United Kingdom; Department of Oncology, University of ...
The enemy of my enemy is my friend
Johns Hopkins Medical Institute, Baltimore, Maryland, USA. Find articles by Voss, S. in: JCI |...
BET bromodomain inhibition potentiates radiosensitivity in models of H3K27-altered diffuse midline glioma
Research ArticleOncologyTherapeutics Open Access | 10.1172/JCI174794 Jun Watanabe,1,2,3,4 M...
White adipocytes in subcutaneous fat depots require KLF15 for maintenance in preclinical models
Klf15 expression is higher in WAT compared with BAT and is suppressed by β-adrenergic signaling. To elucidate the context...
Primary cilia formation requires the Leigh syndrome–associated mitochondrial protein NDUFAF2
Sex as a biological variable. Our study examined a male patient; sex was not considered as a biological variable. Cell cu...
Somatic structural variants drive distinct modes of oncogenesis in melanoma
Cohort overview and subtype-specific SV patterns. We assembled and uniformly analyzed SVs in 355 patients with melanoma W...
Peripherally targeted analgesia via AAV-mediated sensory neuron–specific inhibition of multiple pronociceptive sodium channels
In silico design of 1.7iPAs from NaV1.7-IDRs The candidate iPAs were designed through an a priori strategy aimed at defin...
Cystic fibrosis–related metabolic defects: crosstalk between ion channels and organs
The inter-organ exchange of glucose is paramount to survival. During periods of fasting or metabolic stress, the liver an...
Disordered but effective: short linear motifs as gene therapy targets for hyperexcitability disorders
Voltage-gated sodium (NaV) channels are obligate components of the electrogenic machinery that underlie action potential ...
Keeping it fresh: ribosomal protein SA sustains sarcomeric function via localized translation
To date most studies of localized protein translation have been performed in cultured rodent or human stem cell–derived m...
Epigenetic developmental mechanisms underlying sex differences in cancer
Genomic imprinting is the mechanism for transgenerational transmission of epigenetic adaptations to changing environmenta...
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