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Dual targeting macrophages and microglia is a therapeutic vulnerability in models of PTEN-deficient glioblastoma
Sex as a biological variable. Sex was not considered as a biological variable in this study. Female C57BL/6J mice were us...
TSC/mTORC1 mediates mTORC2/AKT1 signaling in c-MYC–induced murine hepatocarcinogenesis via centromere protein M
Research ArticleHepatologyOncology Open Access | 10.1172/JCI174415 Yi Zhou,1,2 Shu Zhang,...
Pharmacological regeneration of sensory hair cells restores afferent innervation and vestibular function
Drug-induced HC regeneration in Pou4f3DTR-ablated utricles. To ablate HCs, we used Pou4f3DTR transgenic mice, in which th...
Uterine cyclin A2–deficient mice as a model of female early pregnancy loss
Endometrial CCNA2 expression is reduced in women who fail to achieve IVF-assisted pregnancy. Endometrial biopsies were ob...
2024 American Society for Clinical Investigation Presidential AddressSuper chickens, givers, and collective intelligence: the importance of collaboration, teamwork, and mentorship in science
JCI - 2024 American Society for Clinical Investigation Presidential Address: Super chickens, givers, and collective intel...
Inducible CCR2+ nonclassical monocytes mediate the regression of cancer metastasis
Research ArticleImmunology Open Access | 10.1172/JCI179527 Xianpeng Liu,1 Ziyou Ren,2 ...
Cell-cycle machinery is critical in regulating uterine steroid hormone for embryo implantation and development
Cyclins and their cyclin-dependent kinases are critical regulators of cell-cycle progression. Previous work has demonstra...
Nuclear PD-L1 compartmentalization suppresses tumorigenesis and overcomes immunocheckpoint therapy resistance in mice via histone macroH2A1
Research ArticleCell biologyOncology Open Access | 10.1172/JCI181314 Yong Liu,1,2,3,4 Zhi...
Stimulation of an entorhinal-hippocampal extinction circuit facilitates fear extinction in a post-traumatic stress disorder model
Research ArticleNeuroscienceTherapeutics Open Access | 10.1172/JCI181095 Ze-Jie Lin,1,2 X...
Lactate reprograms glioblastoma immunity through CBX3-regulated histone lactylation
GSCs display high levels of histone lactylation augmented by microglia. Consistent with oncogenic metabolic reprogramming...
2024 American Physician Scientists Association Presidential AddressIt takes a village
Emory University, Atlanta, Georgia, USA, National Institutes of Health, Bethesda, Maryland USA, and University of Oxfor...
Neuropilin-2–expressing breast cancer cells mitigate radiation-induced oxidative stress through nitric oxide signaling
Sex as a biological variable The mice utilized in this study were female because human breast cancer largely affects fema...
2024 Association of American Physicians Presidential AddressTransparency, bias, and reproducibility across science: a meta-research view
We all seek reproducibility, but what exactly is reproducibility (22)? We probably all value reproducibility of methods, ...
Parkin paves the path to antitumor immunity: Expanding Parkin’s role as a tumor suppressor
Encoded by the PRKN gene (also known as PARK2), Parkin, a causative gene for autosomal recessive juvenile Parkinsonism (A...
Parkin activates innate immunity and promotes antitumor immune responses
Research ArticleImmunologyOncology Open Access | 10.1172/JCI180983 Michela Perego,1 Minje...
Defects in meiosis I contribute to the genesis of androgenetic hydatidiform moles
Research ArticleGeneticsReproductive biology Open Access | 10.1172/JCI170669 Maryam Rezaei,1 ...
MGA loss-of-function variants cause premature ovarian insufficiency
Research ArticleGeneticsReproductive biology Open Access | 10.1172/JCI183758 Shuyan Tang,1 ...
Xylazine induces dopamine release and augments the effects of fentanyl
Research LetterNeuroscience Open Access | 10.1172/JCI183354 Joseph R. Trinko,1 Ethan Fosc...
Rg3-lipo biomimetic delivery of paclitaxel enhances targeting of tumors and myeloid-derived suppressor cells
Pharmacokinetics and safety profile of PTX-Rg3-lipo treatment in animal models. To determine the pharmacokinetics of PTX-...
Endothelial YAP/TAZ activation promotes atherosclerosis in a mouse model of Hutchinson-Gilford progeria syndrome
scRNA-Seq analysis of wild-type and progeroid mouse aorta. We performed scRNA-Seq to characterize the transcriptional pro...
Postprandial metabolomics analysis reveals disordered serotonin metabolism in post-bariatric hypoglycemia
Clinical parameters. Demographic information was self-reported by participants and is provided in Supplemental Table 1 (s...
Natural TCRs targeting KRASG12V display fine specificity and sensitivity to human solid tumors
Clinical MedicineImmunologyOncology Open Access | 10.1172/JCI175790 Adham S. Bear,1 Rebec...
West Nile virus triggers intestinal dysmotility via T cell–mediated enteric nervous system injury
WNV infection triggers persistent changes in the enteric neuronal network. Our previous work described a dysmotility synd...
More T cell receptors to the RAScue in cancer?
In this issue of the JCI, Bear et al. (11) add to the expanding library of promising TCRs targeting oncogenic KRAS mutati...
Experimental West Nile virus infection provides lessons for recovery from enteric neuropathies
Many infectious diseases alter intestinal functions. Symptoms of such diseases often include diarrhea and constipation th...
IL-13 induces loss of CFTR in ionocytes and reduces airway epithelial fluid absorption
Research ArticlePulmonology Open Access | 10.1172/JCI181995 Guillermo S. Romano Ibarra,1 ...
Targeting TET3 in macrophages provides a concept strategy for the treatment of endometriosis
RNA-Seq analysis revealed that TET3 knockdown particularly changed pathways related to cytokine/chemokine signaling and c...
Modeling primary microcephaly with human brain organoids reveals fundamental roles of CIT kinase activity
Research ArticleCell biologyNeuroscience Open Access | 10.1172/JCI175435 Gianmarco Pallavicin...
Accumulation of Epstein-Barr virus–induced cross-reactive immune responses is associated with multiple sclerosis
Multiple sclerosis (MS) is a chronic autoinflammatory and demyelinating disease of the central nervous system (CNS). The ...
Targeting aryl hydrocarbon receptor functionally restores tolerogenic dendritic cells derived from patients with multiple sclerosis
Monocytes from MS patients are characterized by an activated phenotype. To investigate the potential effect of systemic i...
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