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Evaluation of Contrast-Enhanced Ultrasound in Diagnosis of Acute Kidney Injury of Patients in Intensive Care Unit
Evaluation of Contrast-Enhanced Ultrasound in Diagnosis of Acute Kidney Injury of Patients in Intensive Care Unit
Investigating the value of contrast-enhanced ultrasound (CEUS) in the diagnosis and evaluation of acute kidney injury in i...
The Untapped Potential of the Quadruple Aim of Primary Care to Foster a Culture of Health
The Untapped Potential of the Quadruple Aim of Primary Care to Foster a Culture of Health
This paper explores the inherent synergies between the Quadruple Aim and Culture of Health models, and the untapped potent...
Immune Fitness, Migraine, and Headache Complaints in Individuals with Self-Reported Impaired Wound Healing
Immune Fitness, Migraine, and Headache Complaints in Individuals with Self-Reported Impaired Wound Healing
Evaluating migraine and headache complaints in young adults with self-reported impaired wound healing
TMEM16E regulates endothelial cell procoagulant activity and thrombosis
Research ArticleHematologyVascular biology Open Access | 10.1172/JCI163808 Alec A. Schmaier,1,2...
Two to tango: endothelial cell TMEM16 scramblases drive coagulation and thrombosis
In this issue of the JCI, Schmaier and coauthors identified five proteins as important regulators of factor VIIa–catalyze...
Guidelines for repeated measures statistical analysis approaches with basic science research considerations
The assumptions of a repeated measures ANOVA are that the continuous dependent variable is approximately normally distrib...
Biological rhythms in COVID-19 vaccine effectiveness in an observational cohort study of 1.5 million patients
Clinical MedicineCOVID-19Vaccines Open Access | 10.1172/JCI167339 Guy Hazan,1,2,3 Or A. Due...
Polymerase θ inhibition steps on the cGAS pedal
In the current issue of the JCI, Oh and Wang, et al. report findings that reveal the impact of Pol θ inhibition on immune...
Time of day for COVID vaccine administration linked to clinical effectiveness
Published in Volume 133, Issue 11 on June 1, 2023 J Clin Invest. 2023;133(11):e168233. https://doi.org/10.1172/JCI1682...
IL-6 helps weave the inflammatory web during acute coronary syndromes
Many pathways converged with the identification of a cytokine now named IL-6. The activities now ascribed to IL-6 include...
Exercise, exerkines, and cardiometabolic health: from individual players to a team sport
Reductionist approaches to studying exercise metabolism have generated a wealth of knowledge regarding individual organs ...
Transcription factor HNF4α2 promotes osteogenesis and prevents bone abnormalities in mice with renal osteodystrophy
Research ArticleBone BiologyMetabolism Open Access | 10.1172/JCI159928 Marta Martinez-Calle,1 ...
Disruption of axonal transport in neurodegeneration
Axonal transport is a highly regulated process that can be modified by adaptors, by phosphorylation of motor proteins and...
IL-6 in the infarcted heart is preferentially formed by fibroblasts and modulated by purinergic signaling
Animals. Experimental animals were used at 8–12 weeks of age and had a body weight of 20–25 g. Male C57BL/6J mice (Janvie...
Anaplastic transformation in thyroid cancer revealed by single-cell transcriptomics
Research ArticleGeneticsOncology Open Access | 10.1172/JCI169653 Lina Lu,1,2 Jennifer Rui W...
Long noncoding RNA HITT coordinates with RGS2 to inhibit PD-L1 translation in T cell immunity
HITT promotes T cell immunity. We first compared the anticancer effects of HITT in immune-competent BALB/c mice treated w...
WNK1 promotes water homeostasis by acting as a central osmolality sensor for arginine vasopressin release
Mice with neuron-specific deletion of Wnk1 have polyuria and relative hypotonic urine compared with WT mice. WNK1 kinase ...
Reporting on FH-deficient renal cell carcinoma using circulating succinylated metabolites
The authors deserve commendation for focusing on an unmet medical need, their rational metabolomics approach, the mechani...
Combination of AFP vaccine and immune checkpoint inhibitors slows hepatocellular carcinoma progression in preclinical models
Research ArticleHepatologyImmunology Open Access | 10.1172/JCI163291 Xinjun Lu,1 Shanshan D...
Obesity-induced inflammation exacerbates clonal hematopoiesis
Research ArticleHematologyInflammation Open Access | 10.1172/JCI163968 Santhosh Kumar Pasupulet...
HSV-2 triggers upregulation of MALAT1 in CD4+ T cells and promotes HIV latency reversal
Research ArticleAIDS/HIVVirology Open Access | 10.1172/JCI164317 Carl A. Pierce,1 Lip Nam L...
Long noncoding RNA HIKER regulates erythropoiesis in Monge’s disease via CSNK2B
Patient samples. All subjects used in this study (CMS and non-CMS) were adult males, lifelong residents of Cerro de Pasco...
Preparing for the next viral threat with broad-spectrum antivirals
The cellular machineries co-opted to support the life cycle of viruses are often conserved across viral families, represe...
Effect of a protein kinase B (Akt) inhibitor on the angiogenesis of HUVECs and corneal neovascularization
Effect of a protein kinase B (Akt) inhibitor on the angiogenesis of HUVECs and corneal neovascularization
Corneal neovascularization (CNV) is a vision-threatening disease and an increasing public health concern. It was ...
Application of Monocyte-to-Albumin Ratio and Neutrophil Percentage-to-Hemoglobin Ratio on Distinguishing Non-Small Cell Lung Cancer Patients from Healthy Subjects
Application of Monocyte-to-Albumin Ratio and Neutrophil Percentage-to-Hemoglobin Ratio on Distinguishing Non-Small Cell Lung Cancer Patients from Healthy Subjects
Assessing the benefits of observation of monocyte to albumin ratio and neutrophil percentage to hemoglobin ratio in the de...
Addison’s Disease: Diagnosis and Management Strategies
Addison’s Disease: Diagnosis and Management Strategies
Providing an overview of Addison’s disease (AD) with regard to current diagnosis and management
High Levels of SII and PIV are the Risk Factors of Axillary Lymph Node Metastases in Breast Cancer: A Retrospective Study
High Levels of SII and PIV are the Risk Factors of Axillary Lymph Node Metastases in Breast Cancer: A Retrospective Study
High levels of SII, PIV, VI & HER2 risk factors for axillary lymph node mets. More prospective, multi-center, large sa...
Cystatin C as a Predictor of Major Adverse Cardiovascular Event in Patients with Acute Myocardial Infarction Without Cardiogenic Shock and Renal Impairment After Coronary Intervention
Cystatin C as a Predictor of Major Adverse Cardiovascular Event in Patients with Acute Myocardial Infarction Without Cardiogenic Shock and Renal Impairment After Coronary Intervention
Cystatin C level is an independent predictor of MACE in patients with AMI without cardiogenic shock or renal impairment af...
New Frontiers in Diabetes Care
New Frontiers in Diabetes Care
I read with great interest the article by Tanumihardjo et al., “New Frontiers in Diab...
Spinal Dural Arteriovenous Fistula
Spinal Dural Arteriovenous Fistula
Share this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a sh...
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