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Biochemical Markers of Tumor Cell Sensitivity to L-Asparaginase
Biochemical Markers of Tumor Cell Sensitivity to L-Asparaginase
L-asparaginase, which hydrolyzes asparagine and, to a lesser extent, glutamine, initially used to treat acute lymphoblasti...
Regional Peculiarities of the Prevalence of Polymorphisms in the Genes Involved in the Regulation of Arterial Pressure in Northern Residents of Magadan Oblast
Regional Peculiarities of the Prevalence of Polymorphisms in the Genes Involved in the Regulation of Arterial Pressure in Northern Residents of Magadan Oblast
Introduction. The North is a territory affected by a combination of extreme environmental factors that are stressful for a...
Assessment of the Effect of Age, Renal Function Status, and M-Cholinoblocker Biperidene Intake on Free Plasma Choline Concentrations
Assessment of the Effect of Age, Renal Function Status, and M-Cholinoblocker Biperidene Intake on Free Plasma Choline Concentrations
The use of high-performance liquid chromatography in combination with tandem mass spectrometry (HPLC-MS/MS) provides a sel...
Studying the Effect of Ionizing Radiation on Radiation-Induced Changes in the Cells of the Blood System in Mice at the Organism Level
Studying the Effect of Ionizing Radiation on Radiation-Induced Changes in the Cells of the Blood System in Mice at the Organism Level
The task of studying radiation “bystander effects” at the organism level was set in the work. Irradiated and n...
The Influence of Increased Concentrations of Brain Natriuretic Peptide on the Level of Hemodynamic Reactions in Individuals Living and Working in the European North and the Arctic of the Russian Federation
The Influence of Increased Concentrations of Brain Natriuretic Peptide on the Level of Hemodynamic Reactions in Individuals Living and Working in the European North and the Arctic of the Russian Federation
The authors examined 111 practically healthy individuals (66 women and 45 men aged 46–55 years) living and working i...
A New Human Uveal Melanoma Cell Line: Melanin Production and Molecular Markers for Targeted Therapy
A New Human Uveal Melanoma Cell Line: Melanin Production and Molecular Markers for Targeted Therapy
A new human uveal melanoma (UM) cell line uMel1 was established by mechanical disintegration of a tumor fragment. uMel1 ce...
Adaptation and Experimental Validation of Clinical RNA Sequencing Protocol Oncobox for MGI DNBSEQ-G50 Platform
Adaptation and Experimental Validation of Clinical RNA Sequencing Protocol Oncobox for MGI DNBSEQ-G50 Platform
RNA sequencing (RNAseq) is currently a method of choice for the high-throughput RNA-level analysis of gene expression. Fur...
Effect of Natural Polysaccharides on the Population Density of Klebsiella pneumoniae Isolates In Vitro
Effect of Natural Polysaccharides on the Population Density of Klebsiella pneumoniae Isolates In Vitro
The purpose of the work was to study the influence of natural polysaccharides—arabinogalactan, galactomannan, and ca...
Evaluation of Lipocalin-2 and -10 Levels at Time of Diagnosis in Patients with Acute Pulmonary Embolism
Evaluation of Lipocalin-2 and -10 Levels at Time of Diagnosis in Patients with Acute Pulmonary Embolism
Background: Pulmonary embolism (PE) is an emergent pulmonary vascular pathology with high morbidity and mortality. This st...
The Membrane Penetrating Ability of Opicalcin1 Is Mainly Derived from the Latter Segment in Its Primary Sequence
The Membrane Penetrating Ability of Opicalcin1 Is Mainly Derived from the Latter Segment in Its Primary Sequence
Background: Calcin is a group of globular peptides with 33−35 AAs that penetrate the cell membrane and specially tar...
In Silico Exploration of PTP1B Inhibitor from Indole Alkaloids of Rauvolfia serpentina (L.) Benth, a Potent Therapeutic Drug Target for Type 2 Diabetes Mellitus
In Silico Exploration of PTP1B Inhibitor from Indole Alkaloids of Rauvolfia serpentina (L.) Benth, a Potent Therapeutic Drug Target for Type 2 Diabetes Mellitus
Protein tyrosine phosphatase 1B (PTP1B) is implicated as a key negative regulator of the insulin. Plant derived PTP1B inhi...
Green Synthesis of Silica Nanoparticles/Nanocomposites for Biomedical Applications: A Narraitive Review
Green Synthesis of Silica Nanoparticles/Nanocomposites for Biomedical Applications: A Narraitive Review
Nanomedicine showed the unique benefits in clinical outcomes in comparison with traditional and conventional drugs in the ...
Production of Bacterial Cellulose by Cocultivation of Komagataeibacter sucrofermentans with Producers of Dextran Leuconostoc mesenteroides and Xanthan Xanthomonas campestris
Production of Bacterial Cellulose by Cocultivation of Komagataeibacter sucrofermentans with Producers of Dextran Leuconostoc mesenteroides and Xanthan Xanthomonas campestris
Bacterial cellulose (BC) is an extracellular product of bacterial metabolism. BC has the same molecular formula as plant c...
Antibacterial Activity of Oxadiazole-Montmorillonite Composites
Antibacterial Activity of Oxadiazole-Montmorillonite Composites
Resistance of bacteria to antibiotics is a serious human concern since it affects medical treatments performance against b...
Evaluation of Serum LECT2 and Sclerostin Levels in Patients Followed up for Obstructive Sleep Apnea
Evaluation of Serum LECT2 and Sclerostin Levels in Patients Followed up for Obstructive Sleep Apnea
Background: Obstructive sleep apnea (OSA) is characterized by recurrent apnea/hypopnea in the upper airways and oxygen des...
Dual Effect of Amino Acid Compositions on Antibacterial Activity of Human Neutrophilic Granulocytes
Dual Effect of Amino Acid Compositions on Antibacterial Activity of Human Neutrophilic Granulocytes
It is known that amino acid compositions for parenteral nutrition exhibit an immunomodulatory effect on T and B lymphocyte...
Comparative Analysis of the Primary Structures of Glycoside Hydrolases
Comparative Analysis of the Primary Structures of Glycoside Hydrolases
Fructan-modifying enzymes are divided into fructan-producing enzymes (fructosyl transferases) and fructan hydrolyzing enzy...
Structural Motifs and Spatial Structures of Helicase (NS3) and RNA-Dependent RNA-Polymerase (NS5) of a Flavi-Like Kindia Tick Virus (Unclassified Flaviviridae)
Structural Motifs and Spatial Structures of Helicase (NS3) and RNA-Dependent RNA-Polymerase (NS5) of a Flavi-Like Kindia Tick Virus (Unclassified Flaviviridae)
Kindia tick virus (KITV) is a novel, segmented, unclassified flavi-like virus of the Flaviviridae family. This virus is as...
Modification of the Method for Isolating MicroRNA from Plants by Phenol–Chloroform Extraction Using Polyethylene Glycol 1500
Modification of the Method for Isolating MicroRNA from Plants by Phenol–Chloroform Extraction Using Polyethylene Glycol 1500
MicroRNAs are a class of small noncoding RNAs that are 18 to 25 nucleotides in length and are found in most eukaryotic org...
Modern Molecular Genetic Methods and Prospects for Their Use for Indication and Identification of Yersinia pestis Strains
Modern Molecular Genetic Methods and Prospects for Their Use for Indication and Identification of Yersinia pestis Strains
The review provides an analysis of the literature data on the use of various modern molecular genetic methods for the indi...
Proteolysis and Deficiency of α1-Proteinase Inhibitor in SARS-CoV-2 Infection
Proteolysis and Deficiency of α1-Proteinase Inhibitor in SARS-CoV-2 Infection
The SARS-CoV-2 pandemic had stimulated the emergence of numerous publications on the α1-proteinase inhibitor (α1...
G-Quadruplex Structures in Bacteria: Functional Properties and Prospects for Use as Biotargets
G-Quadruplex Structures in Bacteria: Functional Properties and Prospects for Use as Biotargets
G-quadruplexes (G4), non-canonical secondary DNA structures, have been intensively investigated for a long time. In eukary...
Effect of Ethanol on Platelet Biology
Effect of Ethanol on Platelet Biology
In recent years, there has been interest in the study of platelets, the functions of which, as it turned out, are not limi...
Anti-Ischemic and Antioxidant Activity of the Pharmacological Agonist of Galanin Receptor GalR2 and Carnosine in In Vitro and In Vivo Model Systems
Anti-Ischemic and Antioxidant Activity of the Pharmacological Agonist of Galanin Receptor GalR2 and Carnosine in In Vitro and In Vivo Model Systems
Antioxidant and anti-ischemic properties of the pharmacological agonist of galanin receptor GalR2 WTLNSAGYLLGPβAH (Ga...
Splice Variants of mRNA of Cytochrome P450 Genes: Analysis by the Nanopore Sequencing Method in Human Liver Tissue and HepG2 Cell Line
Splice Variants of mRNA of Cytochrome P450 Genes: Analysis by the Nanopore Sequencing Method in Human Liver Tissue and HepG2 Cell Line
The analysis of cytochrome P450 transcripts was carried out by the nanopore sequencing in liver tissue samples of three do...
Contents of BDNF, miR-30a-5p AND miR-122 during Alcohol Withdrawal Syndrome
Contents of BDNF, miR-30a-5p AND miR-122 during Alcohol Withdrawal Syndrome
Some brain-derived neurotrophic factor (BDNF)-targeted miRNAs such as miR-30a-5p may be associated with alcohol addiction;...
Interaction of Abiraterone and Its Pharmacologically Active Metabolite D4A with Cytochrome P450 2C9 (CYP2C9)
Interaction of Abiraterone and Its Pharmacologically Active Metabolite D4A with Cytochrome P450 2C9 (CYP2C9)
We studied the interaction of the antitumor agent abiraterone and its pharmacologically active metabolite D4A, which is pr...
The Integrin α3β1 Signaling in the Regulation of the SK-Mel-147 Melanoma Cell Senescence
The Integrin α3β1 Signaling in the Regulation of the SK-Mel-147 Melanoma Cell Senescence
Using a model of the human SK-Mel-147 melanoma cell line, it was shown that blocking the expression of integrin α3 ...
Comparative Analysis of Proteins Associated with 26S and 20S Proteasomes Isolated from Rabbit Brain and Liver
Comparative Analysis of Proteins Associated with 26S and 20S Proteasomes Isolated from Rabbit Brain and Liver
The fractions of 26S and 20S proteasomes have been isolated from the rabbit liver and the brain. According to mass spectro...
Population Rearrangement of B Lymphocytes Expressing Chemokine Receptors in Patients with Chronic Obstructive Pulmonary Disease
Population Rearrangement of B Lymphocytes Expressing Chemokine Receptors in Patients with Chronic Obstructive Pulmonary Disease
To date, there are no drugs that can prevent progressive destruction of lung tissue and small airway fibrosis in patients ...
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