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Construction of Expression Vectors for Efficient Production of Recombinant Proteins in E. coli for the Development of Therapeutic Drugs
Construction of Expression Vectors for Efficient Production of Recombinant Proteins in E. coli for the Development of Therapeutic Drugs
When developing vaccines and immunotherapeutic and enzymatic drugs, it is usually necessary to obtain a functional protein...
The Effects of Pretreatment with Atorvastatin, Fenofibrate, or Both Drugs in a Mouse Model of Acute Lipemia Induced by the General Lipase Inhibitor Poloxamer 407
The Effects of Pretreatment with Atorvastatin, Fenofibrate, or Both Drugs in a Mouse Model of Acute Lipemia Induced by the General Lipase Inhibitor Poloxamer 407
Dyslipidemia is a well-known risk factor for the development of cardiovascular diseases and atherosclerosis. The effects o...
The Role of Arachidonic Acid Metabolizing Cytochromes P450 in the Control of Cardiovascular Functions
The Role of Arachidonic Acid Metabolizing Cytochromes P450 in the Control of Cardiovascular Functions
Arachidonic acid (AA) is widely distributed in many organs and can be metabolized in several ways into small lipid molecul...
Effects of Various Poly(A) Tails on Luciferase Expression
Effects of Various Poly(A) Tails on Luciferase Expression
Synthesis of RNA by in vitro transcription has many applications in the production of vaccines, anticancer and gene therap...
Investigating Non-Covalent Interactions of Human Serum Albumin with Doxorubicin and Folic Acid
Investigating Non-Covalent Interactions of Human Serum Albumin with Doxorubicin and Folic Acid
The development of effective delivery systems for antitumor drugs with increased specificity and controlled release is one...
Expression of miR-21, miR-378a, miR-205, and Their Targets in ER-Positive Breast Tumors with Different HER2 Protein Levels
Expression of miR-21, miR-378a, miR-205, and Their Targets in ER-Positive Breast Tumors with Different HER2 Protein Levels
Tyrosine protein kinase HER2 plays an important role in carcinogenesis. In breast cancer (BC), the HER2 gene is amplified ...
Deep Learning Methods for Binding Site Prediction in Protein Structures
Deep Learning Methods for Binding Site Prediction in Protein Structures
This work is an overview of deep machine learning methods aimed at predicting binding sites in protein structures. Several...
Calorie Restriction Decreases JAK-STAT Pathway Gene Expression, Tumor Mass and Activity of Glutathione-Dependent Enzymes
Calorie Restriction Decreases JAK-STAT Pathway Gene Expression, Tumor Mass and Activity of Glutathione-Dependent Enzymes
Melanoma is one of the most aggressive types of cancer. Melanoma morbidity is increasing every year and mortality rate is ...
Effect of Autophagy Regulators on FcεRI-Dependent Activation of the RBL-2H3 Cells
Effect of Autophagy Regulators on FcεRI-Dependent Activation of the RBL-2H3 Cells
Mast cells (MCs) are an important population of connective tissue cells that play a key role in the development of allergi...
Exploring the Cause of Survival Disparities in EGFR-Mutated Lung Cancer Subtypes: Unraveling Distinctive Genomic and Phenotypic Features of 19Del and L858R Mutation Subtypes
Exploring the Cause of Survival Disparities in EGFR-Mutated Lung Cancer Subtypes: Unraveling Distinctive Genomic and Phenotypic Features of 19Del and L858R Mutation Subtypes
Different efficacy of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) has been observed between lun...
LINC00654–SOX5 mRNA-miRNA-133a Compose New RNA Panel for Colorectal Cancer (CRC): A Potential Diagnostic Panel for CRC
LINC00654–SOX5 mRNA-miRNA-133a Compose New RNA Panel for Colorectal Cancer (CRC): A Potential Diagnostic Panel for CRC
Many disorders can be accurately diagnosed using ribonucleic acids (RNAs). A panel of RNAs specific to colorectal cancer (...
Ultrastructure of Mitochondria in Skeletal Muscle Weakened by Sarcopenia during Aging
Ultrastructure of Mitochondria in Skeletal Muscle Weakened by Sarcopenia during Aging
The processes of progressive decrease in muscle mass and weakening of mitochondrial function that occur during aging in sk...
Association of 25(OH) Vitamin D with Cardiometabolic Risk Factors in the Age Aspect
Association of 25(OH) Vitamin D with Cardiometabolic Risk Factors in the Age Aspect
Background: This study assessed the association of vitamin D status with the frequency of incidence of metabolic health ri...
CUL5 Is Involved in Proteasome-Degradation of BiP in Breast Cancer Cells
CUL5 Is Involved in Proteasome-Degradation of BiP in Breast Cancer Cells
The E3 ubiquitin ligase Cullin 5 (CUL5) has been linked to a variety of cell biological functions, such as developmental p...
Levels of IgG to Food Antigens in Practically Healthy People and with Metabolic Syndrome
Levels of IgG to Food Antigens in Practically Healthy People and with Metabolic Syndrome
The study compared the content of IgG specific to 90 food antigens in practically healthy people and in people with metabo...
Glycation and Glucose Variability in Subjects with Type 1 Diabetes
Glycation and Glucose Variability in Subjects with Type 1 Diabetes
High glucose variability (GV) and increased glycation may play a role in the development of diabetes complications. We aim...
Investigating the Role of KLF6-SV1 as a Regulator of EMT Progression
Investigating the Role of KLF6-SV1 as a Regulator of EMT Progression
Post-translational modifications (PTMs) are crucial for all biological processes and offer insights into protein functions...
Synthesis, Spectral, and Structural Investigations and Anticancer Activity In Vitro of the New Organotin Complexes
Synthesis, Spectral, and Structural Investigations and Anticancer Activity In Vitro of the New Organotin Complexes
The series of new organotin complexes on the basis of bis(trimethylsilylmethyl)tin diсhloride, 1,1-dichloro-1-stanna...
Investigation of the Several Aspects of Interaction between Human Serum Albumin and Oleic Acid by Molecular Dynamic Simulation Approaches and Spectroscopic Methods
Investigation of the Several Aspects of Interaction between Human Serum Albumin and Oleic Acid by Molecular Dynamic Simulation Approaches and Spectroscopic Methods
The most predominant fatty acid in olive oil, oleic acid (OA), lowers LDL (low-density lipoprotein) cholesterol and may ra...
Medicinal Applications and Prospects of Tetra- and Tripyrrole Compounds
Medicinal Applications and Prospects of Tetra- and Tripyrrole Compounds
This review is devoted to some areas of medicinal application of pyrrole-containing macroheterocycles. Two main applicatio...
Biochemical Markers of Tumor Cell Sensitivity to L-Asparaginase
Biochemical Markers of Tumor Cell Sensitivity to L-Asparaginase
L-asparaginase, which hydrolyzes asparagine and, to a lesser extent, glutamine, initially used to treat acute lymphoblasti...
Regional Peculiarities of the Prevalence of Polymorphisms in the Genes Involved in the Regulation of Arterial Pressure in Northern Residents of Magadan Oblast
Regional Peculiarities of the Prevalence of Polymorphisms in the Genes Involved in the Regulation of Arterial Pressure in Northern Residents of Magadan Oblast
Introduction. The North is a territory affected by a combination of extreme environmental factors that are stressful for a...
Assessment of the Effect of Age, Renal Function Status, and M-Cholinoblocker Biperidene Intake on Free Plasma Choline Concentrations
Assessment of the Effect of Age, Renal Function Status, and M-Cholinoblocker Biperidene Intake on Free Plasma Choline Concentrations
The use of high-performance liquid chromatography in combination with tandem mass spectrometry (HPLC-MS/MS) provides a sel...
Studying the Effect of Ionizing Radiation on Radiation-Induced Changes in the Cells of the Blood System in Mice at the Organism Level
Studying the Effect of Ionizing Radiation on Radiation-Induced Changes in the Cells of the Blood System in Mice at the Organism Level
The task of studying radiation “bystander effects” at the organism level was set in the work. Irradiated and n...
The Influence of Increased Concentrations of Brain Natriuretic Peptide on the Level of Hemodynamic Reactions in Individuals Living and Working in the European North and the Arctic of the Russian Federation
The Influence of Increased Concentrations of Brain Natriuretic Peptide on the Level of Hemodynamic Reactions in Individuals Living and Working in the European North and the Arctic of the Russian Federation
The authors examined 111 practically healthy individuals (66 women and 45 men aged 46–55 years) living and working i...
A New Human Uveal Melanoma Cell Line: Melanin Production and Molecular Markers for Targeted Therapy
A New Human Uveal Melanoma Cell Line: Melanin Production and Molecular Markers for Targeted Therapy
A new human uveal melanoma (UM) cell line uMel1 was established by mechanical disintegration of a tumor fragment. uMel1 ce...
Adaptation and Experimental Validation of Clinical RNA Sequencing Protocol Oncobox for MGI DNBSEQ-G50 Platform
Adaptation and Experimental Validation of Clinical RNA Sequencing Protocol Oncobox for MGI DNBSEQ-G50 Platform
RNA sequencing (RNAseq) is currently a method of choice for the high-throughput RNA-level analysis of gene expression. Fur...
Effect of Natural Polysaccharides on the Population Density of Klebsiella pneumoniae Isolates In Vitro
Effect of Natural Polysaccharides on the Population Density of Klebsiella pneumoniae Isolates In Vitro
The purpose of the work was to study the influence of natural polysaccharides—arabinogalactan, galactomannan, and ca...
Evaluation of Lipocalin-2 and -10 Levels at Time of Diagnosis in Patients with Acute Pulmonary Embolism
Evaluation of Lipocalin-2 and -10 Levels at Time of Diagnosis in Patients with Acute Pulmonary Embolism
Background: Pulmonary embolism (PE) is an emergent pulmonary vascular pathology with high morbidity and mortality. This st...
The Membrane Penetrating Ability of Opicalcin1 Is Mainly Derived from the Latter Segment in Its Primary Sequence
The Membrane Penetrating Ability of Opicalcin1 Is Mainly Derived from the Latter Segment in Its Primary Sequence
Background: Calcin is a group of globular peptides with 33−35 AAs that penetrate the cell membrane and specially tar...
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