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Effect of dynamic exclusion and the use of FAIMS, DIA and MALDI-mass spectrometry imaging with ion mobility on amyloid protein identification
Effect of dynamic exclusion and the use of FAIMS, DIA and MALDI-mass spectrometry imaging with ion mobility on amyloid protein identification
Amyloidosis is a disease characterized by local and systemic extracellular deposition of amyloid protein fibrils where its...
Proteome profiling of cutaneous leishmaniasis lesions due to dermotropic Leishmania donovani in Sri Lanka
Proteome profiling of cutaneous leishmaniasis lesions due to dermotropic Leishmania donovani in Sri Lanka
Characterization of the host response in cutaneous leishmaniasis (CL) through proteome profiling has gained limited insigh...
Resistin as a potential diagnostic biomarker for sepsis: insights from DIA and ELISA analyses
Resistin as a potential diagnostic biomarker for sepsis: insights from DIA and ELISA analyses
The primary objective of this investigation is to systematically screen and identify differentially expressed proteins (DE...
A single-sample workflow for joint metabolomic and proteomic analysis of clinical specimens
A single-sample workflow for joint metabolomic and proteomic analysis of clinical specimens
Understanding the interplay of the proteome and the metabolome helps to understand cellular regulation and response. To en...
ESF1 and MIPEP proteins promote estrogen receptor-positive breast cancer proliferation and are associated with patient prognosis
ESF1 and MIPEP proteins promote estrogen receptor-positive breast cancer proliferation and are associated with patient prognosis
Estrogen receptor-positive (ER+) breast cancer accounts for two-thirds of all breast cancers, and its early and late recur...
Early detection of breast cancer through the diagnosis of Nipple Aspirate Fluid (NAF)
Early detection of breast cancer through the diagnosis of Nipple Aspirate Fluid (NAF)
The development of breast cancer has been mainly reported in women who have reached the post-menopausal stage; therefore, ...
Proteomic profiling of prostate cancer reveals molecular signatures under antiandrogen treatment
Proteomic profiling of prostate cancer reveals molecular signatures under antiandrogen treatment
Tumorigenesis and progression of prostate cancer (PCa) are indispensably dependent on androgen receptor (AR). Antiandrogen...
Frontiers in plasma proteome profiling platforms: innovations and applications
Frontiers in plasma proteome profiling platforms: innovations and applications
Biomarkers play a crucial role in advancing precision medicine by enabling more targeted and individualized approaches to ...
Identification of brain-enriched proteins in CSF as biomarkers of relapsing remitting multiple sclerosis
Identification of brain-enriched proteins in CSF as biomarkers of relapsing remitting multiple sclerosis
Multiple sclerosis (MS) is a clinically and biologically heterogenous disease with currently unpredictable progression and...
Glial fibrillary acidic protein, neurofilament light, matrix metalloprotease 3 and fatty acid binding protein 4 as non-invasive brain tumor biomarkers
Glial fibrillary acidic protein, neurofilament light, matrix metalloprotease 3 and fatty acid binding protein 4 as non-invasive brain tumor biomarkers
Gliomas are aggressive malignant tumors, with poor prognosis. There is an unmet need for the discovery of new, non-invasiv...
Elevated level of multibranched complex glycan reveals an allergic tolerance status
Elevated level of multibranched complex glycan reveals an allergic tolerance status
Allergen immunotherapy (AIT) is the only disease-modifying therapy that can achieve immune tolerance in patients through l...
Proteomic profiling of extracellular vesicles derived from human serum for the discovery of biomarkers in Avascular necrosis
Proteomic profiling of extracellular vesicles derived from human serum for the discovery of biomarkers in Avascular necrosis
Avascular necrosis (AVN) is a medical condition characterized by the destruction of bone tissue due to a diminished blood ...
Differentiation between descending thoracic aortic diseases using machine learning and plasma proteomic signatures
Differentiation between descending thoracic aortic diseases using machine learning and plasma proteomic signatures
Descending thoracic aortic aneurysms and dissections can go undetected until severe and catastrophic, and few clinical ind...
Proteomic snapshot of saliva samples predicts new pathways implicated in SARS-CoV-2 pathogenesis
Proteomic snapshot of saliva samples predicts new pathways implicated in SARS-CoV-2 pathogenesis
Information on the microbiome's human pathways and active members that can affect SARS-CoV-2 susceptibility and pathog...
Aqueous humor proteomics analyzed by bioinformatics and machine learning in PDR cases versus controls
Aqueous humor proteomics analyzed by bioinformatics and machine learning in PDR cases versus controls
To comprehend the complexities of pathophysiological mechanisms and molecular events that contribute to proliferative diab...
Correlation between small-cell lung cancer serum protein/peptides determined by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and chemotherapy efficacy
Correlation between small-cell lung cancer serum protein/peptides determined by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and chemotherapy efficacy
Currently, no effective measures are available to predict the curative efficacy of small-cell lung cancer (SCLC) chemother...
A reduced proteomic signature in critically ill Covid-19 patients determined with plasma antibody micro-array and machine learning
A reduced proteomic signature in critically ill Covid-19 patients determined with plasma antibody micro-array and machine learning
COVID-19 is a complex, multi-system disease with varying severity and symptoms. Identifying changes in critically ill COVI...
Evaluation of a proteomic signature coupled with the kidney failure risk equation in predicting end stage kidney disease in a chronic kidney disease cohort
Evaluation of a proteomic signature coupled with the kidney failure risk equation in predicting end stage kidney disease in a chronic kidney disease cohort
The early identification of patients at high-risk for end-stage renal disease (ESRD) is essential for providing optimal ca...
Mapping dynamic molecular changes in hippocampal subregions after traumatic brain injury through spatial proteomics
Mapping dynamic molecular changes in hippocampal subregions after traumatic brain injury through spatial proteomics
Traumatic brain injury (TBI) often results in diverse molecular responses, challenging traditional proteomic studies that ...
Multiplex proteomics identifies inflammation-related plasma biomarkers for aging and cardio-metabolic disorders
Multiplex proteomics identifies inflammation-related plasma biomarkers for aging and cardio-metabolic disorders
Cardio-metabolic disorders (CMDs) are common in aging people and are pivotal risk factors for cardiovascular diseases (CVD...
Proteomics study of primary and recurrent adamantinomatous craniopharyngiomas
Proteomics study of primary and recurrent adamantinomatous craniopharyngiomas
Adamantinomatous craniopharyngiomas (ACPs) are rare benign epithelial tumours with high recurrence and poor prognosis. Bio...
The relationship between serum astroglial and neuronal markers and AQP4 and MOG autoantibodies
The relationship between serum astroglial and neuronal markers and AQP4 and MOG autoantibodies
Certain demyelinating disorders, such as neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycopr...
Plasma proteomic characterization of colorectal cancer patients with FOLFOX chemotherapy by integrated proteomics technology
Plasma proteomic characterization of colorectal cancer patients with FOLFOX chemotherapy by integrated proteomics technology
Colorectal Cancer (CRC) is a prevalent form of cancer, and the effectiveness of the main postoperative chemotherapy treatm...
Simultaneous targeted and discovery-driven clinical proteotyping using hybrid-PRM/DIA
Simultaneous targeted and discovery-driven clinical proteotyping using hybrid-PRM/DIA
Clinical samples are irreplaceable, and their transformation into searchable and reusable digital biobanks is critical for...
Quantitative proteomic analysis of HER2 protein expression in PDAC tumors
Quantitative proteomic analysis of HER2 protein expression in PDAC tumors
Metastatic pancreatic adenocarcinoma (PDAC) is the third leading cause of cancer-related death in the United States, with ...
Neat plasma proteomics: getting the best out of the worst
Neat plasma proteomics: getting the best out of the worst
Plasma proteomics holds immense potential for clinical research and biomarker discovery, serving as a non-invasive "l...
Proteomics of prostate cancer serum and plasma using low and high throughput approaches
Proteomics of prostate cancer serum and plasma using low and high throughput approaches
Despite progress, MS-based proteomics in biofluids, especially blood, faces challenges such as dynamic range and throughpu...
Proteomic analysis of breast cancer based on immune subtypes
Proteomic analysis of breast cancer based on immune subtypes
Immunotherapy is applied to breast cancer to resolve the limitations of survival gain in existing treatment modalities. Wi...
Highly sensitive therapeutic drug monitoring of infliximab in serum by targeted mass spectrometry in comparison to ELISA data
Highly sensitive therapeutic drug monitoring of infliximab in serum by targeted mass spectrometry in comparison to ELISA data
Presently, antibody concentration measurements for patients undergoing treatment are predominantly determined by ELISA, wh...
Closing the gaps in patient management of dyslipidemia: stepping into cardiovascular precision diagnostics with apolipoprotein profiling
Closing the gaps in patient management of dyslipidemia: stepping into cardiovascular precision diagnostics with apolipoprotein profiling
In persons with dyslipidemia, a high residual risk of cardiovascular disease remains despite lipid lowering therapy. Curre...
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