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Genotype–phenotype correlation in a large cohort of pediatric patients with heterozygous and homozygous familial hypercholesterolemia
Genotype–phenotype correlation in a large cohort of pediatric patients with heterozygous and homozygous familial hypercholesterolemia
Background Familial hypercholesterolemia (FH) is a genetic disorder characterized by elevated low
Strategies of improving adherence to lipid-lowering therapy in patients with atherosclerotic cardiovascular disease
Strategies of improving adherence to lipid-lowering therapy in patients with atherosclerotic cardiovascular disease
Purpose of review Lowering LDL-C has been shown to reduce ASCVD events, yet many ASCVD patients d
Ups and downs in PCSK9 inhibition in the cardiovascular arena: a review
Ups and downs in PCSK9 inhibition in the cardiovascular arena: a review
Purpose of review This article reviews PCSK9 inhibitors (PCSK9i) with a focus on clinically relev
The pathophysiology of excess plasma-free cholesterol
The pathophysiology of excess plasma-free cholesterol
Purpose of review Several large studies have shown increased mortality due to all-causes and to a
Predictors of cardiovascular risk in familial hypercholesterolemia
Predictors of cardiovascular risk in familial hypercholesterolemia
Purpose of review Familial hypercholesterolemia is associated with an increased risk of cardiovas
Triglyceride-rich lipoprotein cholesterol and cardiovascular risk
Triglyceride-rich lipoprotein cholesterol and cardiovascular risk
Purpose of review The triglyceride-rich apoB lipoprotein particles make up a minority of the apoB
Sweet swell of burning fat: emerging role of high-density lipoprotein in energy homeostasis
Sweet swell of burning fat: emerging role of high-density lipoprotein in energy homeostasis
Purpose of review Metabolism of lipids and lipoproteins, including high-density lipoprotein (HDL)
Angiopoietin-like 3 inhibition and the liver: less is more?
Angiopoietin-like 3 inhibition and the liver: less is more?
Purpose of review The aim of this study was to discuss the potential mechanisms and implications
The multiple roles of lysophosphatidic acid in vascular disease and atherosclerosis
The multiple roles of lysophosphatidic acid in vascular disease and atherosclerosis
Purpose of review To explore the multiple roles that lysophosphatidic acid (LPA) plays in vascula
Aspirin and lipoprotein(a) in primary prevention
Aspirin and lipoprotein(a) in primary prevention
Purpose of review Lipoprotein(a) [Lp(a)] is causally associated with cardiovascular diseases, and
A new SPRING in lipid metabolism
A new SPRING in lipid metabolism
Purpose of review The SREBP transcription factors are master regulators of lipid homeostasis owin
Phospholipid transport by ABCA1: the extracellular translocase or alternating access model?
Phospholipid transport by ABCA1: the extracellular translocase or alternating access model?
Purpose of review ATP-binding cassette transporter A1 (ABCA1) plays a key role in high-density li
Macrophage inflammarafts in atherosclerosis
Macrophage inflammarafts in atherosclerosis
Purpose of review Advances in single cell techniques revealed a remarkable diversity in macrophag
Established and potential cardiovascular risk factors in metabolic syndrome: Effect of bariatric surgery
Established and potential cardiovascular risk factors in metabolic syndrome: Effect of bariatric surgery
Purpose of review The aim of this review was to provide an overview of the role of novel biomarke
Considerations for routinely testing for high lipoprotein(a)
Considerations for routinely testing for high lipoprotein(a)
Purpose of review Lipoprotein (a) [Lp(a)] is a likely causal risk factor for atherosclerotic card
Inclisiran: present and future perspectives of a new effective LDL cholesterol-lowering agent
Inclisiran: present and future perspectives of a new effective LDL cholesterol-lowering agent
Purpose of review To highlight critical aspects of inclisiran, from preclinical studies to curren
Bempedoic acid for nonalcoholic fatty liver disease: evidence and mechanisms of action
Bempedoic acid for nonalcoholic fatty liver disease: evidence and mechanisms of action
Purpose of review Nonalcoholic fatty liver disease (NAFLD) is a highly prevalent progressive cond
Updates in the management of pediatric dyslipidemia
Updates in the management of pediatric dyslipidemia
Purpose of review Pediatric dyslipidemias increase the risk of atherosclerosis and clinical cardi
Oxidized LDL receptors: a recent update
Oxidized LDL receptors: a recent update
Purpose of review LDL in its oxidized form, or ‘oxLDL’, is now generally acknowledged to be highl
Assessment of cardiovascular disease risk: a 2023 update
Assessment of cardiovascular disease risk: a 2023 update
Purpose of review The aim of this study was to highlight the current best practice for atheroscle
Cardiomyocytes, sphingolipids and cardio myotoxicity
Cardiomyocytes, sphingolipids and cardio myotoxicity
Purpose of review Sphingolipids are structurally diverse membrane lipids localized in lipid bilay
Inflammation compared to low-density lipoprotein cholesterol: two different causes of atherosclerotic cardiovascular disease
Inflammation compared to low-density lipoprotein cholesterol: two different causes of atherosclerotic cardiovascular disease
Purpose of review Inflammation is gaining attention as a target for prevention of atherosclerotic
Nonalcoholic fatty liver disease: an update
Nonalcoholic fatty liver disease: an update
Purpose of review We discuss two recent controversial issues in the research field of fatty liver
Familial hypercholesterolemia: The nexus of endothelial dysfunction and lipoprotein metabolism in COVID-19
Familial hypercholesterolemia: The nexus of endothelial dysfunction and lipoprotein metabolism in COVID-19
Purpose of review Patients with heterozygous familial hypercholesterolemia (HeFH) are at increase
Triglyceride-rich lipoproteins, remnant-cholesterol, and atherosclerotic cardiovascular disease
Triglyceride-rich lipoproteins, remnant-cholesterol, and atherosclerotic cardiovascular disease
Purpose of review Despite indisputable role of LDL-C lowering, a considerable residual risk for a
Assessment of atherosclerosis: should coronary calcium score and intima-media thickness be replaced by ultrasound measurement of carotid plaque burden and vessel wall volume?
Assessment of atherosclerosis: should coronary calcium score and intima-media thickness be replaced by ultrasound measurement of carotid plaque burden and vessel wall volume?
Purpose of review To describe the uses of vessel wall volume (VWV) and measurement of carotid pla
Lipid metabolism
Lipid metabolism
Division of Endocrinology & Metabolism, Faculty of Health Sciences, University of the Witwatersrand, Johannesbu...
Novel therapeutic opportunities for familial lecithin:cholesterol acyltransferase deficiency: promises and challenges
Novel therapeutic opportunities for familial lecithin:cholesterol acyltransferase deficiency: promises and challenges
Purpose of review Genetic lecithin:cholesterol acyltransferase (LCAT) deficiency is a rare, inher
The clinical utility of polygenic risk scores for combined hyperlipidemia
The clinical utility of polygenic risk scores for combined hyperlipidemia
Purpose of review Combined hyperlipidemia is the most common lipid disorder and is strongly polyg
Genetic determinants of pancreatitis: relevance in severe hypertriglyceridemia
Genetic determinants of pancreatitis: relevance in severe hypertriglyceridemia
Purpose of review Not all patients with severe hypertriglyceridemia develop acute pancreatitis. W
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