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Long Noncoding RNA ISA1 Protects Against Ischemic Brain Damage by Promoting the Transformation of Microglia Toward Anti-inflammatory Phenotype via the SOCS3/JAK2/STAT3 Pathway
Long Noncoding RNA ISA1 Protects Against Ischemic Brain Damage by Promoting the Transformation of Microglia Toward Anti-inflammatory Phenotype via the SOCS3/JAK2/STAT3 Pathway
The shift of microglia towards an anti-inflammatory phenotype has been shown to decrease neuroinflammation, improve neurol...
MTOR Promotes Astrocyte Activation and Participates in Neuropathic Pain through an Upregulation of RIP3
MTOR Promotes Astrocyte Activation and Participates in Neuropathic Pain through an Upregulation of RIP3
Neuropathic pain (NP), a chronic pain condition, is the result of abnormalities in both central and peripheral pain conduc...
The Role of Small Extracellular Vesicles Derived from Glial Cells in the Central Nervous System under both Normal and Pathological Conditions
The Role of Small Extracellular Vesicles Derived from Glial Cells in the Central Nervous System under both Normal and Pathological Conditions
In recent decades, researchers and clinicians have increasingly focused on glial cell function. One of the primary mechani...
Dental Pulp Stem Cells Attenuate Early Brain Injury After Subarachnoid Hemorrhage via miR-26a-5p/PTEN/AKT Pathway
Dental Pulp Stem Cells Attenuate Early Brain Injury After Subarachnoid Hemorrhage via miR-26a-5p/PTEN/AKT Pathway
Subarachnoid hemorrhage (SAH) is a type of hemorrhagic stroke with high morbidity, mortality and disability, and early bra...
Hydrogen Sulfide (H2S) Generated in the Colon Induces Neuropathic Pain by Activating Spinal NMDA Receptors in a Rodent Model of Chronic Constriction Injury
Hydrogen Sulfide (H2S) Generated in the Colon Induces Neuropathic Pain by Activating Spinal NMDA Receptors in a Rodent Model of Chronic Constriction Injury
Neuropathic pain (NP) imposes a significant burden on individuals, manifesting as nociceptive anaphylaxis, hypersensitivit...
Correction to: β-Caryophyllene Liposomes Attenuate Neurovascular Unit Damage After Subarachnoid Hemorrhage in Rats
Correction to: β-Caryophyllene Liposomes Attenuate Neurovascular Unit Damage After Subarachnoid Hemorrhage in Rats
Cite this articleWang, F., Teng, Z., Liu, D. et al. Correction to: β-Caryophyllene Liposomes Attenuate Neurovascular Unit ...
Varenicline Attenuates Memory Impairment in Amyloid-Beta-Induced Rat Model of Alzheimer’s Disease
Varenicline Attenuates Memory Impairment in Amyloid-Beta-Induced Rat Model of Alzheimer’s Disease
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder characterized by cognitive decline. Despit...
The Regulation of Messenger RNAs and Biological Pathways by Long Non-Coding RNAs and Circular RNAs in Ischemic Stroke
The Regulation of Messenger RNAs and Biological Pathways by Long Non-Coding RNAs and Circular RNAs in Ischemic Stroke
Our aim was to evaluate the regulation of messenger RNAs (mRNAs) and biological pathways by long non-coding RNAs (lncRNAs)...
Role of Glial Cells and Receptors in Schizophrenia Pathogenesis
Role of Glial Cells and Receptors in Schizophrenia Pathogenesis
The specific pathogeneses of schizophrenia (SCZ) remain an enigma despite extensive research that has implicated both gene...
FTO Suppresses Proliferation and Induces Apoptosis of T98G Glioblastoma Cells via N6-methyladenosine Modification of GSTO1
FTO Suppresses Proliferation and Induces Apoptosis of T98G Glioblastoma Cells via N6-methyladenosine Modification of GSTO1
Glioblastoma (GBM) is the most malignant type of glioma with a very poor prognosis. N6-methyladenosine (m6A) is well-docum...
Methionine Sulfoximine as a Tool for Studying Temporal Lobe Epilepsy: Initiator, Developer, Attenuator
Methionine Sulfoximine as a Tool for Studying Temporal Lobe Epilepsy: Initiator, Developer, Attenuator
Methionine sulfoximine (MSO) is a compound originally discovered as a byproduct of agene-based milled flour maturation. MS...
Nanoparticle Interactions with the Blood Brain Barrier: Insights from Drosophila and Implications for Human Astrocyte Targeted Therapies
Nanoparticle Interactions with the Blood Brain Barrier: Insights from Drosophila and Implications for Human Astrocyte Targeted Therapies
This review explores the intricate connections between Drosophila models and the human blood-brain barrier (BBB) with nano...
Exploring Ubiquitination in Spinal Cord Injury Therapy: Multifaceted Targets and Promising Strategies
Exploring Ubiquitination in Spinal Cord Injury Therapy: Multifaceted Targets and Promising Strategies
Spinal cord injury (SCI) is a severely debilitating neurological condition that often results in significant functional im...
Intermittent Fasting Improves Sevoflurane-Induced Cognitive Dysfunction in Rats Through SIRT1-Mediated Autophagy
Intermittent Fasting Improves Sevoflurane-Induced Cognitive Dysfunction in Rats Through SIRT1-Mediated Autophagy
Perioperative neurocognitive disorders (PND) is a common complication affecting the central nervous system, commonly induc...
Blackcurrant (Ribes nigrum L.) and Its Association with Donepezil Restore Cognitive Impairment, Suppress Oxidative Stress and Pro-inflammatory Responses, and Improve Purinergic Signaling in a Scopolamine-Induced Amnesia Model in Mice
Blackcurrant (Ribes nigrum L.) and Its Association with Donepezil Restore Cognitive Impairment, Suppress Oxidative Stress and Pro-inflammatory Responses, and Improve Purinergic Signaling in a Scopolamine-Induced Amnesia Model in Mice
Purinergic signaling plays a major role in aging and neurodegenerative diseases, which are associated with memory decline....
Trehalose Inhibits ferroptosis Through Activating SIRT3/SOD2 Signaling Axis and Alleviates Brain Injury After Traumatic Brain Injury
Trehalose Inhibits ferroptosis Through Activating SIRT3/SOD2 Signaling Axis and Alleviates Brain Injury After Traumatic Brain Injury
Trehalose has neuroprotective effects in neurodegenerative diseases. This study aimed to explore the impact of trehalose o...
Glycyrrhizic Acid Mitigates Haloperidol-Induced Neurotoxicity in SHSY-5Y Cells and Rats Via Activation of PI3k/Akt/Nrf2 Pathways
Glycyrrhizic Acid Mitigates Haloperidol-Induced Neurotoxicity in SHSY-5Y Cells and Rats Via Activation of PI3k/Akt/Nrf2 Pathways
Antipsychotic medications are used to treat a psychological condition called ‘Schizophrenia’. However, its lon...
Identification of a Subpopulation of Astrocyte Progenitor Cells in the Neonatal Subventricular Zone: Evidence that Migration is Regulated by Glutamate Signaling
Identification of a Subpopulation of Astrocyte Progenitor Cells in the Neonatal Subventricular Zone: Evidence that Migration is Regulated by Glutamate Signaling
In mice engineered to express enhanced green fluorescent protein (eGFP) under the control of the entire glutamate transpor...
α-Ketoisocaproic Acid Disrupts Mitochondrial Bioenergetics in the Brain of Neonate Rats: Molecular Modeling Studies of α-ketoglutarate Dehydrogenase Subunits Inhibition
α-Ketoisocaproic Acid Disrupts Mitochondrial Bioenergetics in the Brain of Neonate Rats: Molecular Modeling Studies of α-ketoglutarate Dehydrogenase Subunits Inhibition
Brain accumulation of the branched-chain α-keto acids α-ketoisocaproic acid (KIC), α-keto-β-methylvale...
Regulation of Glutamate Transporter Type 1 by TSA and the Antiepileptic Mechanism of TSA
Regulation of Glutamate Transporter Type 1 by TSA and the Antiepileptic Mechanism of TSA
Epilepsy (EP) is a neurological disorder characterized by abnormal, sudden neuronal discharges. Seizures increase extracel...
Challenges of Investigating Compartmentalized Brain Energy Metabolism Using Nuclear Magnetic Resonance Spectroscopy in vivo
Challenges of Investigating Compartmentalized Brain Energy Metabolism Using Nuclear Magnetic Resonance Spectroscopy in vivo
Brain function requires continuous energy supply. Thus, unraveling brain metabolic regulation is critical not only for our...
Neohesperidin Improves Depressive-Like Behavior Induced by Chronic Unpredictable Mild Stress in Mice
Neohesperidin Improves Depressive-Like Behavior Induced by Chronic Unpredictable Mild Stress in Mice
Depression is a common and complex neuropsychiatric disorder affecting people of all ages worldwide, associated with high ...
Breaking Barriers in Huntington’s Disease Therapy: Focused Ultrasound for Targeted Drug Delivery
Breaking Barriers in Huntington’s Disease Therapy: Focused Ultrasound for Targeted Drug Delivery
Huntington’s disease (HD) is a progressive neurodegenerative disease resulting from a mutation in the huntingtin (HT...
PKR Inhibitor C16 Regulates HIV-gp120 Induced Neuronal Injury and Cognitive Impairment in Vivo and in Vitro Models
PKR Inhibitor C16 Regulates HIV-gp120 Induced Neuronal Injury and Cognitive Impairment in Vivo and in Vitro Models
To study the neuronal protective effect and its potential mechanism of C16 against gp120-induced cognitive impairment in v...
The Role of Acetylcholinesterase Enzyme Inhibitor Rivastigmine on Spike-Wave Discharges, Learning-Memory, Anxiety, and TRPV1 Channel Expression in Genetic Absence Epileptic WAG/Rij Rats
The Role of Acetylcholinesterase Enzyme Inhibitor Rivastigmine on Spike-Wave Discharges, Learning-Memory, Anxiety, and TRPV1 Channel Expression in Genetic Absence Epileptic WAG/Rij Rats
In the present study, the effects of the acetylcholinesterase (AChE) enzyme inhibitor rivastigmine (RIVA) on spike-wave di...
Mechanism of Sirtuin1-Mediated Deacetylation of p65-Mediated Ferroptosis of Hippocampal Neurons in Cerebral Injury after Cardiopulmonary Resuscitation in Rats
Mechanism of Sirtuin1-Mediated Deacetylation of p65-Mediated Ferroptosis of Hippocampal Neurons in Cerebral Injury after Cardiopulmonary Resuscitation in Rats
Objective: Post-resuscitation brain injury is a common sequela after cardiac arrest (CA). Increasing sirtuin1 (SIRT1) has ...
The Role of Oligodendrocyte Lineage Cells in the Pathogenesis of Alzheimer’s Disease
The Role of Oligodendrocyte Lineage Cells in the Pathogenesis of Alzheimer’s Disease
Alzheimer’s disease (AD) is a central nervous system degenerative disease with a stealthy onset and a progressive co...
Gene Deficiency of δ Subunit-Containing GABAA Receptor in mPFC Lead Learning and Memory Impairment in Mice
Gene Deficiency of δ Subunit-Containing GABAA Receptor in mPFC Lead Learning and Memory Impairment in Mice
Maintaining GABAergic inhibition within physiological limits in the medial prefrontal cortex (mPFC) is critical for workin...
Correction: 4,5-Dimethoxycanthin-6-one Inhibits Glioblastoma Stem Cell and Tumor Growth by Inhibiting TSPAN1 Interaction with TM4SF1
Correction: 4,5-Dimethoxycanthin-6-one Inhibits Glioblastoma Stem Cell and Tumor Growth by Inhibiting TSPAN1 Interaction with TM4SF1
In this article, Fig. 2B, TM4SF1 and β-actin are placed inversely in the results of U87 cells; and part of Fig. 4, the res...
Neuroinflammatory Response in the Traumatic Brain Injury: An Update
Neuroinflammatory Response in the Traumatic Brain Injury: An Update
The central nervous system (CNS) comprises membranes and barriers that are vital to brain homeostasis. Membranes form a ro...
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