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Exploring α-synuclein Interaction Partners and their Potential Clinical Implications for Parkinson’s Disease
Exploring α-synuclein Interaction Partners and their Potential Clinical Implications for Parkinson’s Disease
Alpha-synuclein aggregates are strongly associated with Parkinson’s disease (PD), a degenerative neurological disord...
GABA Receptors and Kv7 Channels as Targets for GABAergic Regulation of Acetylcholine Release in Frog Neuromuscular Junction
GABA Receptors and Kv7 Channels as Targets for GABAergic Regulation of Acetylcholine Release in Frog Neuromuscular Junction
Effects of gamma-aminobutyric acid (GABA) and some selective GABAergic ligands on the quantal acetylcholine (ACh) release ...
Maresin-1 Ameliorates Sepsis-Induced Microglial Activation Through Modulation of the P38 MAPK Pathway
Maresin-1 Ameliorates Sepsis-Induced Microglial Activation Through Modulation of the P38 MAPK Pathway
Sepsis is a life-threatening disease characterized by a dysregulated immune response to infection, often leading to neuroi...
Differential Effects of Itaconate and its Esters on the Glutathione and Glucose Metabolism of Cultured Primary Rat Astrocytes
Differential Effects of Itaconate and its Esters on the Glutathione and Glucose Metabolism of Cultured Primary Rat Astrocytes
Itaconate is produced as endogenous metabolite by decarboxylation of the citric acid cycle intermediate cis-aconitate. As ...
l-Proline Alters Energy Metabolism in Brain Cortical Tissue Slices
l-Proline Alters Energy Metabolism in Brain Cortical Tissue Slices
L-Proline (l-Pro) is a non-essential amino acid which, in high concentrations, can cause neurological problems including s...
Naringenin Protected Against Blood Brain Barrier Breakdown after Ischemic Stroke through GSK-3β/ β-Catenin Pathway
Naringenin Protected Against Blood Brain Barrier Breakdown after Ischemic Stroke through GSK-3β/ β-Catenin Pathway
Protection against blood-brain barrier (BBB) dysfunction is key to reduce the cerebral ischemia injury as its breakdown ca...
Atractylenolide-I Attenuates MPTP/MPP+‑Mediated Oxidative Stress in Parkinson’s Disease Through SIRT1/PGC‑1α/Nrf2 Axis
Atractylenolide-I Attenuates MPTP/MPP+‑Mediated Oxidative Stress in Parkinson’s Disease Through SIRT1/PGC‑1α/Nrf2 Axis
Parkinson’s disease (PD) is typically marked by motor dysfunction accompanied by loss of dopaminergic (DA) neurons a...
AMP-Activated Protein Kinase Treatment Ameliorates Chronic Restraint Stress Induced Memory Impairment in Early Adolescent Rat by Restoring Metabolite Profile and Synaptic Proteins
AMP-Activated Protein Kinase Treatment Ameliorates Chronic Restraint Stress Induced Memory Impairment in Early Adolescent Rat by Restoring Metabolite Profile and Synaptic Proteins
Recent studies highlight the role of brain metabolites in regulation of neuronal signals and behaviour. To understand the ...
Resveratrol Enhances the Efficacy of Combined BM-MSCs Therapy for Rat Spinal Cord Injury via Modulation of the Sirt-1/NF-κB Signaling Pathway
Resveratrol Enhances the Efficacy of Combined BM-MSCs Therapy for Rat Spinal Cord Injury via Modulation of the Sirt-1/NF-κB Signaling Pathway
Spinal cord injury (SCI) represents a severe trauma to the central nervous system, resulting in significant disability and...
ATP Restoration by ATP-Deprived Cultured Primary Astrocytes
ATP Restoration by ATP-Deprived Cultured Primary Astrocytes
A high cellular concentration of adenosine triphosphate (ATP) is essential to fuel many important functions of brain astro...
Morin Ameliorates Lipopolysaccharides-Induced Sepsis-Associated Encephalopathy and Cognitive Impairment in Albino Mice
Morin Ameliorates Lipopolysaccharides-Induced Sepsis-Associated Encephalopathy and Cognitive Impairment in Albino Mice
Sepsis-associated encephalopathy is a common neurological complication of sepsis that is characterized by neuroinflammatio...
Inhibition of PCSK9 Protects against Cerebral Ischemia‒Reperfusion Injury via Attenuating Microcirculatory Dysfunction
Inhibition of PCSK9 Protects against Cerebral Ischemia‒Reperfusion Injury via Attenuating Microcirculatory Dysfunction
Proprotein convertase substilin/kexin type 9 (PCSK9), a pivotal protein regulating lipid metabolism, has been implicated i...
20-Hydroxyeicosatetraenoic Acid Regulates the Src/EGFR/NF-κB Signaling Pathway Via GPR75 to Activate Microglia and Promote TBI in the Immature Brain
20-Hydroxyeicosatetraenoic Acid Regulates the Src/EGFR/NF-κB Signaling Pathway Via GPR75 to Activate Microglia and Promote TBI in the Immature Brain
20-Hydroxyeicosatetraenoic acid (20-HETE) is associated with secondary damage in traumatic brain injury (TBI) of the immat...
Lactobacillus Helveticus Improves Controlled Cortical Impact Injury-Generated Neurological Aberrations by Remodeling of Gut-Brain Axis Mediators
Lactobacillus Helveticus Improves Controlled Cortical Impact Injury-Generated Neurological Aberrations by Remodeling of Gut-Brain Axis Mediators
Considerable studies augured the potential of gut microbiota-based interventions in brain injury-associated complications....
Longitudinal Monitoring of Glutathione Stability in Different Microenvironments
Longitudinal Monitoring of Glutathione Stability in Different Microenvironments
Glutathione (GSH) is a master antioxidant which primarily protects cells from oxidative stress. Clinical studies have foun...
Effect of JM-20 on Age-Related Cognitive Impairment in Mice
Effect of JM-20 on Age-Related Cognitive Impairment in Mice
The decline in cognitive function associated with aging significantly impacts the well-being of elderly individuals and th...
Nicotinamide and Nicotinoyl-Gamma-Aminobutyric Acid as Neuroprotective Agents Against Type 1 Diabetes-Induced Nervous System Impairments in Rats
Nicotinamide and Nicotinoyl-Gamma-Aminobutyric Acid as Neuroprotective Agents Against Type 1 Diabetes-Induced Nervous System Impairments in Rats
Diabetes is a multifunctional chronic disease that affects both the central and/or peripheral nervous systems. This study ...
Consequences of a 2-Deoxyglucose Exposure on the ATP Content and the Cytosolic Glucose Metabolism of Cultured Primary Rat Astrocytes
Consequences of a 2-Deoxyglucose Exposure on the ATP Content and the Cytosolic Glucose Metabolism of Cultured Primary Rat Astrocytes
The glucose analogue 2-deoxyglucose (2DG) has frequently been used as a tool to study cellular glucose uptake and to inhib...
Neuromedin U Neurons in the Edinger–Westphal Nucleus Respond to Alcohol Without Interfering with the Urocortin 1 Response
Neuromedin U Neurons in the Edinger–Westphal Nucleus Respond to Alcohol Without Interfering with the Urocortin 1 Response
The Edinger–Westphal nucleus (EW) is a midbrain nucleus composed of a preganglionic, cholinergic subpopulation and a...
Activation of the LKB1/AMPK/HIF-1α Pathway by Metformin to Promote Neovascularisation in Cerebral Ischaemia
Activation of the LKB1/AMPK/HIF-1α Pathway by Metformin to Promote Neovascularisation in Cerebral Ischaemia
As a difficult-to-treat neurological condition, cerebral ischemia is currently limited to treatments such as intravenous r...
Mirtazapine Improves Locomotor Activity and Attenuates Neuropathic Pain Following Spinal Cord Injury in Rats via Neuroinflammation Modulation
Mirtazapine Improves Locomotor Activity and Attenuates Neuropathic Pain Following Spinal Cord Injury in Rats via Neuroinflammation Modulation
Neuroinflammation-related locomotor deficits and neuropathic pain are expected outcomes of spinal cord injury (SCI). The a...
High-fat and High-sucrose Diet-induced Hypothalamic Inflammation Shows Sex Specific Features in Mice
High-fat and High-sucrose Diet-induced Hypothalamic Inflammation Shows Sex Specific Features in Mice
Hypothalamic inflammation underlies diet-induced obesity and diabetes in rodent models. While diet normalization largely a...
Ferulic Acid-Loaded Nanostructure Maintains Brain Levels of ACh, Glutamate, and GABA and Ameliorates Anxiety and Memory Impairments Induced by the d-Galactose Aging Process in Rats
Ferulic Acid-Loaded Nanostructure Maintains Brain Levels of ACh, Glutamate, and GABA and Ameliorates Anxiety and Memory Impairments Induced by the d-Galactose Aging Process in Rats
Population aging is a global reality driven by increased life expectancy. This demographic phenomenon is intrinsically lin...
Neuroprotective Properties of Coriander-Derived Compounds on Neuronal Cell Damage under Oxidative Stress-Induced SH-SY5Y Neuroblastoma and in Silico ADMET Analysis
Neuroprotective Properties of Coriander-Derived Compounds on Neuronal Cell Damage under Oxidative Stress-Induced SH-SY5Y Neuroblastoma and in Silico ADMET Analysis
An imbalance between reactive oxygen species (ROS) production and antioxidant defense driven by oxidative stress and infla...
A Retrospective Tribute to Dr. Harish Pant (1938–2023) and His Seminal Work on Cyclin Dependent Kinase 5
A Retrospective Tribute to Dr. Harish Pant (1938–2023) and His Seminal Work on Cyclin Dependent Kinase 5
Dr. Harish Chandra Pant was Chief of the Section on Neuronal Cytoskeletal Protein Regulation within the National Institute...
In Vivo Glucose Transporter-2 Regulation of Dorsomedial Versus Ventrolateral VMN Astrocyte Metabolic Sensor and Glycogen Metabolic Enzyme Gene Expression in Female Rat
In Vivo Glucose Transporter-2 Regulation of Dorsomedial Versus Ventrolateral VMN Astrocyte Metabolic Sensor and Glycogen Metabolic Enzyme Gene Expression in Female Rat
Astrocyte glycogenolysis shapes ventromedial hypothalamic nucleus (VMN) regulation of glucostasis in vivo. Glucose transpo...
Emerging Trends: Neurofilament Biomarkers in Precision Neurology
Emerging Trends: Neurofilament Biomarkers in Precision Neurology
Neurofilaments are structural proteins found in the cytoplasm of neurons, particularly in axons, providing structural supp...
Progress of Astrocyte-Neuron Crosstalk in Central Nervous System Diseases
Progress of Astrocyte-Neuron Crosstalk in Central Nervous System Diseases
Neurons are the primary cells responsible for information processing in the central nervous system (CNS). However, they ar...
Zona Incerta GABAergic Neurons Facilitate Emergence from Isoflurane Anesthesia in Mice
Zona Incerta GABAergic Neurons Facilitate Emergence from Isoflurane Anesthesia in Mice
The zona incerta (ZI) predominantly consists of gamma-aminobutyric acid (GABAergic) neurons, located adjacent to the later...
Sodium Butyrate Ameliorates Postoperative Delirium by Regulating Gut Microbiota Dysbiosis to Inhibit Astrocyte Activation in Aged Mice
Sodium Butyrate Ameliorates Postoperative Delirium by Regulating Gut Microbiota Dysbiosis to Inhibit Astrocyte Activation in Aged Mice
Postoperative delirium (POD) is a common complication in elderly surgical patients, with limited targeted interventions du...
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