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Simvastatin Differentially Modulates Glial Functions in Cultured Cortical and Hypothalamic Astrocytes Derived from Interferon α/β Receptor Knockout mice
Simvastatin Differentially Modulates Glial Functions in Cultured Cortical and Hypothalamic Astrocytes Derived from Interferon α/β Receptor Knockout mice
Astrocytes have key regulatory roles in central nervous system (CNS), integrating metabolic, inflammatory and synaptic res...
Transplantation of Neural Stem Cells-Overexpressed Ku70 Improves Neurological Deficits in a Mice Model of Cerebral Ischemia Stroke
Transplantation of Neural Stem Cells-Overexpressed Ku70 Improves Neurological Deficits in a Mice Model of Cerebral Ischemia Stroke
Cerebral ischemic stroke is a cerebrovascular disease, which is related to DNA damage. Many researches have shown that Ku7...
CircRNA and Stroke: New Insight of Potential Biomarkers and Therapeutic Targets
CircRNA and Stroke: New Insight of Potential Biomarkers and Therapeutic Targets
Stroke, the second-largest cause of death and the leading cause of disability globally, presents significant challenges in...
HSP90 Inhibition Attenuated Isoflurane-Induced Neurotoxicity in Mice and Human Neuroglioma Cells
HSP90 Inhibition Attenuated Isoflurane-Induced Neurotoxicity in Mice and Human Neuroglioma Cells
Isoflurane, a widely used inhalation anesthetic in clinical practice, is associated with an increased risk of neuronal inj...
Narirutin Attenuates Cerebral Ischemia-Reperfusion Injury by Suppressing the TXNIP/NLRP3 Pathway
Narirutin Attenuates Cerebral Ischemia-Reperfusion Injury by Suppressing the TXNIP/NLRP3 Pathway
Narirutin (Nar) is a flavonoid that is abundantly present in citrus fruits and has attracted considerable attention becaus...
Streptozotocin-Induced Diabetic Rats Showed a Differential Glycine Receptor Expression in the Spinal Cord: A GlyR Role in Diabetic Neuropathy
Streptozotocin-Induced Diabetic Rats Showed a Differential Glycine Receptor Expression in the Spinal Cord: A GlyR Role in Diabetic Neuropathy
In the spinal cord, attenuation of the inhibitory action of glycine is related to an increase in both inflammatory and dia...
The Possible Role of Brain-derived Neurotrophic Factor in Epilepsy
The Possible Role of Brain-derived Neurotrophic Factor in Epilepsy
Epilepsy is a neurological disease characterized by repeated seizures. Despite of that the brain-derived neurotrophic fact...
Hexavalent Chromium Induces Neurotoxicity by Triggering Mitochondrial Dysfunction and ROS-Mediated Signals
Hexavalent Chromium Induces Neurotoxicity by Triggering Mitochondrial Dysfunction and ROS-Mediated Signals
Hexavalent chromium (Cr (VI)), one of the most detrimental pollutants, has been ubiquitously present in the environment an...
Nutritional Support of Crocin on Neurobehavioral Disabilities Induced by Cisplatin-Based Chemotherapy in Rats
Nutritional Support of Crocin on Neurobehavioral Disabilities Induced by Cisplatin-Based Chemotherapy in Rats
Cisplatin, a chemotherapy drug containing platinum, is considered a neurotoxic agent. On the other hand, crocin, the prima...
Pathogenesis of Depression in Alzheimer’s Disease
Pathogenesis of Depression in Alzheimer’s Disease
Depression is a prevalent occurrence among Alzheimer’s disease (AD) patients, yet its underlying mechanism remains u...
Akt/mTOR Pathway Agonist SC79 Inhibits Autophagy and Apoptosis of Oligodendrocyte Precursor Cells Associated with Neonatal White Matter Dysplasia
Akt/mTOR Pathway Agonist SC79 Inhibits Autophagy and Apoptosis of Oligodendrocyte Precursor Cells Associated with Neonatal White Matter Dysplasia
White matter dysplasia (WMD) in preterm infants due to intrauterine inflammation is caused by excessive apoptosis of oligo...
Serum Proteomics Identified TAFI as a Potential Molecule Facilitating the Migration of Peripheral Monocytes to Damaged White Matter During Chronic Cerebral Hypoperfusion
Serum Proteomics Identified TAFI as a Potential Molecule Facilitating the Migration of Peripheral Monocytes to Damaged White Matter During Chronic Cerebral Hypoperfusion
Neuroinflammation is assumed as the critical pathophysiologic mechanism of white matter lesions (WMLs), and infiltrated pe...
Anandamide Attenuates Neurobehavioral Deficits and EEG Irregularities in the Chronic Sleep Deprivation Rats: The Role of Oxidative Stress and Neuroinflammation
Anandamide Attenuates Neurobehavioral Deficits and EEG Irregularities in the Chronic Sleep Deprivation Rats: The Role of Oxidative Stress and Neuroinflammation
Sleep deprivation increases stress, anxiety, and depression by altering the endocannabinoid system’s function. In th...
Involvement of PI3K/AKT Pathway in the Rapid Antidepressant Effects of Crocetin in Mice with Depression-Like Phenotypes
Involvement of PI3K/AKT Pathway in the Rapid Antidepressant Effects of Crocetin in Mice with Depression-Like Phenotypes
The current first-line antidepressants have the drawback of slow onset, which greatly affects the treatment of depression....
Natural Phenolic Compounds with Neuroprotective Effects
Natural Phenolic Compounds with Neuroprotective Effects
Neurodegenerative disorders are characterized by mitochondrial dysfunction and subsequently oxidative stress, inflammation...
Restraint Stress, Foot Shock and Corticosterone Differentially Alter Autophagy in the Rat Hippocampus, Basolateral Amygdala and Prefrontal Cortex
Restraint Stress, Foot Shock and Corticosterone Differentially Alter Autophagy in the Rat Hippocampus, Basolateral Amygdala and Prefrontal Cortex
Autophagy is a conserved lysosomal degradation process that has recently been found to be associated with stress-related p...
Upregulation of Spinal MDGA1 in Rats After Nerve Injury Alters Interactions Between Neuroligin-2 and Postsynaptic Scaffolding Proteins and Increases GluR1 Subunit Surface Delivery in the Spinal Cord Dorsal Horn
Upregulation of Spinal MDGA1 in Rats After Nerve Injury Alters Interactions Between Neuroligin-2 and Postsynaptic Scaffolding Proteins and Increases GluR1 Subunit Surface Delivery in the Spinal Cord Dorsal Horn
Previous studies suggested that postsynaptic neuroligin-2 may shift from inhibitory toward excitatory function under patho...
Microglia-Dependent Reversal of Depression-Like Behaviors in Chronically Stressed Mice by Administration of a Specific Immuno-stimulant β-Glucan
Microglia-Dependent Reversal of Depression-Like Behaviors in Chronically Stressed Mice by Administration of a Specific Immuno-stimulant β-Glucan
In recent years, the decline of microglia in the hippocampus has been shown to play a role in the development of depressio...
miR-122-5p Promotes Peripheral and Central Nervous System Inflammation in a Mouse Model of Intracerebral Hemorrhage via Disruption of the MLLT1/PI3K/AKT Signaling
miR-122-5p Promotes Peripheral and Central Nervous System Inflammation in a Mouse Model of Intracerebral Hemorrhage via Disruption of the MLLT1/PI3K/AKT Signaling
Intracerebral hemorrhage (ICH) is a recognized central nervous system inflammation complication. Several microRNAs (miRNAs...
Compound Dihuang Granule Changes Gut Microbiota of MPTP-Induced Parkinson’s Disease Mice via Inhibiting TLR4/NF-κB Signaling
Compound Dihuang Granule Changes Gut Microbiota of MPTP-Induced Parkinson’s Disease Mice via Inhibiting TLR4/NF-κB Signaling
Intestinal microbiota was connected to Parkinson’s Disease (PD) pathology. The ancient Chinese medication for PD is ...
Remote Ischaemic Preconditioning Accelerates Brain to Blood Glutamate Efflux via EAATs-mediated Transport
Remote Ischaemic Preconditioning Accelerates Brain to Blood Glutamate Efflux via EAATs-mediated Transport
Remote ischaemic conditioning (RIC) becomes an attractive strategy for the endogenous stimulation of mechanisms protecting...
Neuroprotective Effects of Dammarane Sapogenins Against lipopolysaccharide-induced Cognitive Impairment, Neuroinflammation and Synaptic Dysfunction
Neuroprotective Effects of Dammarane Sapogenins Against lipopolysaccharide-induced Cognitive Impairment, Neuroinflammation and Synaptic Dysfunction
Neuroinflammation is a critical driver in the pathogenesis and progression of neurodegenerative disorders. Dammarane sapog...
The m6A Reader YTHDF1 Improves Sevoflurane-Induced Neuronal Pyroptosis and Cognitive Dysfunction Through Augmenting CREB-BDNF Signaling
The m6A Reader YTHDF1 Improves Sevoflurane-Induced Neuronal Pyroptosis and Cognitive Dysfunction Through Augmenting CREB-BDNF Signaling
Sevoflurane is one of the most widely used anesthetics in surgery which is the main cause of postoperative cognitive dysfu...
Tat-CCT2 Protects the Neurons from Ischemic Damage by Reducing Oxidative Stress and Activating Autophagic Removal of Damaged Protein in the Gerbil Hippocampus
Tat-CCT2 Protects the Neurons from Ischemic Damage by Reducing Oxidative Stress and Activating Autophagic Removal of Damaged Protein in the Gerbil Hippocampus
CCT2 is a eukaryotic chaperonin TCP-1 ring complex subunit that mediates protein folding, autophagosome incorporation, and...
Metformin Improves Comorbid Depressive Symptoms in Mice with Allergic Rhinitis by Reducing Olfactory Bulb Damage
Metformin Improves Comorbid Depressive Symptoms in Mice with Allergic Rhinitis by Reducing Olfactory Bulb Damage
Allergic rhinitis (AR) is a widespread disease that is frequently comorbid with depression. However, the mechanisms and tr...
The Effects and Mechanisms of Xanthones in Alzheimer’s Disease: A Systematic Review
The Effects and Mechanisms of Xanthones in Alzheimer’s Disease: A Systematic Review
Xanthones are natural secondary metabolites that possess great potential as neuroprotective agents due to their prominent ...
Research Progress of Antioxidants in Oxidative Stress Therapy after Spinal Cord Injury
Research Progress of Antioxidants in Oxidative Stress Therapy after Spinal Cord Injury
Spinal cord injury (SCI) is a serious problem in the central nervous system resulting in high disability and mortality wit...
The Protective Effect of Lithium Against Rotenone may be Evolutionarily Conserved: Evidence from Eisenia fetida, a Primitive Animal with a Ganglionic Brain
The Protective Effect of Lithium Against Rotenone may be Evolutionarily Conserved: Evidence from Eisenia fetida, a Primitive Animal with a Ganglionic Brain
Chronic exposure to stress is a non-adaptive situation that is associated with mitochondrial dysfunction and the accumulat...
Toll-like Receptor 2-Melatonin Feedback Loop Regulates the Activation of Spinal NLRP3 Inflammasome in Morphine-Tolerant Rats
Toll-like Receptor 2-Melatonin Feedback Loop Regulates the Activation of Spinal NLRP3 Inflammasome in Morphine-Tolerant Rats
Background and Purpose: Morphine is amongst the most effective analgesics available for the management of severe pain. How...
Transforming Growth Factor β1 Ameliorates Microglial Activation in Perioperative Neurocognitive Disorders
Transforming Growth Factor β1 Ameliorates Microglial Activation in Perioperative Neurocognitive Disorders
Perioperative neurocognitive disorder (PND) is a common complication of surgery and anesthesia, especially among older pat...
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