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Activation of the LKB1/AMPK/HIF-1α Pathway by Metformin to Promote Neovascularisation in Cerebral Ischaemia
Activation of the LKB1/AMPK/HIF-1α Pathway by Metformin to Promote Neovascularisation in Cerebral Ischaemia
As a difficult-to-treat neurological condition, cerebral ischemia is currently limited to treatments such as intravenous r...
Mirtazapine Improves Locomotor Activity and Attenuates Neuropathic Pain Following Spinal Cord Injury in Rats via Neuroinflammation Modulation
Mirtazapine Improves Locomotor Activity and Attenuates Neuropathic Pain Following Spinal Cord Injury in Rats via Neuroinflammation Modulation
Neuroinflammation-related locomotor deficits and neuropathic pain are expected outcomes of spinal cord injury (SCI). The a...
High-fat and High-sucrose Diet-induced Hypothalamic Inflammation Shows Sex Specific Features in Mice
High-fat and High-sucrose Diet-induced Hypothalamic Inflammation Shows Sex Specific Features in Mice
Hypothalamic inflammation underlies diet-induced obesity and diabetes in rodent models. While diet normalization largely a...
Ferulic Acid-Loaded Nanostructure Maintains Brain Levels of ACh, Glutamate, and GABA and Ameliorates Anxiety and Memory Impairments Induced by the d-Galactose Aging Process in Rats
Ferulic Acid-Loaded Nanostructure Maintains Brain Levels of ACh, Glutamate, and GABA and Ameliorates Anxiety and Memory Impairments Induced by the d-Galactose Aging Process in Rats
Population aging is a global reality driven by increased life expectancy. This demographic phenomenon is intrinsically lin...
Neuroprotective Properties of Coriander-Derived Compounds on Neuronal Cell Damage under Oxidative Stress-Induced SH-SY5Y Neuroblastoma and in Silico ADMET Analysis
Neuroprotective Properties of Coriander-Derived Compounds on Neuronal Cell Damage under Oxidative Stress-Induced SH-SY5Y Neuroblastoma and in Silico ADMET Analysis
An imbalance between reactive oxygen species (ROS) production and antioxidant defense driven by oxidative stress and infla...
A Retrospective Tribute to Dr. Harish Pant (1938–2023) and His Seminal Work on Cyclin Dependent Kinase 5
A Retrospective Tribute to Dr. Harish Pant (1938–2023) and His Seminal Work on Cyclin Dependent Kinase 5
Dr. Harish Chandra Pant was Chief of the Section on Neuronal Cytoskeletal Protein Regulation within the National Institute...
In Vivo Glucose Transporter-2 Regulation of Dorsomedial Versus Ventrolateral VMN Astrocyte Metabolic Sensor and Glycogen Metabolic Enzyme Gene Expression in Female Rat
In Vivo Glucose Transporter-2 Regulation of Dorsomedial Versus Ventrolateral VMN Astrocyte Metabolic Sensor and Glycogen Metabolic Enzyme Gene Expression in Female Rat
Astrocyte glycogenolysis shapes ventromedial hypothalamic nucleus (VMN) regulation of glucostasis in vivo. Glucose transpo...
Emerging Trends: Neurofilament Biomarkers in Precision Neurology
Emerging Trends: Neurofilament Biomarkers in Precision Neurology
Neurofilaments are structural proteins found in the cytoplasm of neurons, particularly in axons, providing structural supp...
Progress of Astrocyte-Neuron Crosstalk in Central Nervous System Diseases
Progress of Astrocyte-Neuron Crosstalk in Central Nervous System Diseases
Neurons are the primary cells responsible for information processing in the central nervous system (CNS). However, they ar...
Zona Incerta GABAergic Neurons Facilitate Emergence from Isoflurane Anesthesia in Mice
Zona Incerta GABAergic Neurons Facilitate Emergence from Isoflurane Anesthesia in Mice
The zona incerta (ZI) predominantly consists of gamma-aminobutyric acid (GABAergic) neurons, located adjacent to the later...
Sodium Butyrate Ameliorates Postoperative Delirium by Regulating Gut Microbiota Dysbiosis to Inhibit Astrocyte Activation in Aged Mice
Sodium Butyrate Ameliorates Postoperative Delirium by Regulating Gut Microbiota Dysbiosis to Inhibit Astrocyte Activation in Aged Mice
Postoperative delirium (POD) is a common complication in elderly surgical patients, with limited targeted interventions du...
Spontaneous Calcium Transients Recorded from Striatal Astrocytes in a Preclinical Model of Autism
Spontaneous Calcium Transients Recorded from Striatal Astrocytes in a Preclinical Model of Autism
Autism spectrum disorder (ASD) is known as a group of neurodevelopmental conditions including stereotyped and repetitive b...
Epigenetic Mechanisms of Aluminum-Induced Neurotoxicity and Alzheimer’s Disease: A Focus on Non-Coding RNAs
Epigenetic Mechanisms of Aluminum-Induced Neurotoxicity and Alzheimer’s Disease: A Focus on Non-Coding RNAs
Aluminum (Al) is known to induce neurotoxic effects, potentially contributing to Alzheimer’s disease (AD) pathogenes...
Correction to: Histone Deacetylase Inhibitor RGFP109 Overcomes Temozolomide Resistance by Blocking NF-κB-Dependent Transcription in Glioblastoma Cell Lines
Correction to: Histone Deacetylase Inhibitor RGFP109 Overcomes Temozolomide Resistance by Blocking NF-κB-Dependent Transcription in Glioblastoma Cell Lines
Brain Center, Department of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery, Shenzhen Second People’s Hospital, The ...
Wnt Signaling Modulators Exhibit Neuroprotective Effects via Combating Astrogliosis and Balancing Synaptic Density at Early and Late Stage Temporal Lobe Epilepsy
Wnt Signaling Modulators Exhibit Neuroprotective Effects via Combating Astrogliosis and Balancing Synaptic Density at Early and Late Stage Temporal Lobe Epilepsy
Temporal Lobe Epilepsy (TLE) is a severe neurological condition characterized by recurrent seizures that often do not resp...
Brief Pup Separation in Lactation Confers Stress Resistance with Increased Prolactin and Adult Hippocampal Neurogenesis in Postpartum C57BL/6J Dams
Brief Pup Separation in Lactation Confers Stress Resistance with Increased Prolactin and Adult Hippocampal Neurogenesis in Postpartum C57BL/6J Dams
Prolactin (PRL) assumes a pivotal role during the postpartum phase, particularly within the hippocampus—a region den...
Age- and Sex-Associated Wnt Signaling Dysregulation is Exacerbated from the Early Stages of Neuropathology in an Alzheimer’s Disease Model
Age- and Sex-Associated Wnt Signaling Dysregulation is Exacerbated from the Early Stages of Neuropathology in an Alzheimer’s Disease Model
Emerging studies suggest that Wnt signaling is dysregulated in the brains of AD patients, suggesting that this pathway may...
Changes in Noradrenergic Synthesis and Dopamine Beta-Hydroxylase Activity in Response to Oxidative Stress after Iron-induced Brain Injury
Changes in Noradrenergic Synthesis and Dopamine Beta-Hydroxylase Activity in Response to Oxidative Stress after Iron-induced Brain Injury
Noradrenaline (NA) levels are altered during the first hours and several days after cortical injury. NA modulates motor fu...
Therapeutic Options of Crystallin Mu and Protein Disulfide Isomerase A3 for Cuprizone-Induced Demyelination in Mouse Hippocampus
Therapeutic Options of Crystallin Mu and Protein Disulfide Isomerase A3 for Cuprizone-Induced Demyelination in Mouse Hippocampus
This study investigates the changes in hippocampal proteomic profiles during demyelination and remyelination using the cup...
The Involvement of the Ventral Tegmental Area in the Electroacupuncture Alleviation of Anxiety-Like Behaviors Induced by Chronic Restraint Stress in Mice
The Involvement of the Ventral Tegmental Area in the Electroacupuncture Alleviation of Anxiety-Like Behaviors Induced by Chronic Restraint Stress in Mice
Emotional stress is a significant environmental risk factor for various mental health disabilities, such as anxiety. Elect...
Pre-electroacupuncture Ameliorates Cerebral Ischemia-reperfusion Injury by Inhibiting Microglial RhoA/pyrin/GSDMD Signaling Pathway
Pre-electroacupuncture Ameliorates Cerebral Ischemia-reperfusion Injury by Inhibiting Microglial RhoA/pyrin/GSDMD Signaling Pathway
Cerebral ischemia reperfusion injury is a severe neurological impairment that occurs after blood flow reconstruction in st...
Targeting Adipokines: A Promising Therapeutic Strategy for Epilepsy
Targeting Adipokines: A Promising Therapeutic Strategy for Epilepsy
Epilepsy affects 65 million people globally and causes neurobehavioral, cognitive, and psychological defects. Alt...
The Interplay of Carveol and All-Trans Retinoic Acid (ATRA) in Experimental Parkinson’s Disease: Role of Inflammasome-Mediated Pyroptosis and Nrf2
The Interplay of Carveol and All-Trans Retinoic Acid (ATRA) in Experimental Parkinson’s Disease: Role of Inflammasome-Mediated Pyroptosis and Nrf2
Parkinson’s disease (PD) is a debilitating and the second most common neurodegenerative disorder with a high prevale...
Ketogenic Diets Alter the Gut Microbiome, Resulting in Decreased Susceptibility to and Cognitive Impairment in Rats with Pilocarpine-Induced Status Epilepticus
Ketogenic Diets Alter the Gut Microbiome, Resulting in Decreased Susceptibility to and Cognitive Impairment in Rats with Pilocarpine-Induced Status Epilepticus
A ketogenic diet (KD) is a high-fat, low-carbohydrate, and low-protein diet that exerts antiepileptic effects by attenuati...
NMN Synbiotics: A Multifaceted Therapeutic Approach for Alzheimer’s Disease
NMN Synbiotics: A Multifaceted Therapeutic Approach for Alzheimer’s Disease
With the aging global population, Alzheimer’s disease (AD) has become a significant social and economic burden, nece...
Dexmedetomidine Promotes NREM Sleep by Depressing Oxytocin Neurons in the Paraventricular Nucleus in Mice
Dexmedetomidine Promotes NREM Sleep by Depressing Oxytocin Neurons in the Paraventricular Nucleus in Mice
Dexmedetomidine (DEX) is a highly selective α2-adrenoceptor agonist with sedative effects on sleep homeostasis. Oxyto...
Single-cell RNA Sequencing Identifies a Novel Subtype of Microglia with High Cd74 Expression that Facilitates White Matter Inflammation During Chronic Cerebral Hypoperfusion
Single-cell RNA Sequencing Identifies a Novel Subtype of Microglia with High Cd74 Expression that Facilitates White Matter Inflammation During Chronic Cerebral Hypoperfusion
Vascular dementia (VaD) causes progressive cognitive decline in the elderly population, but there is short of available th...
Epidermal Neural Crest Stem Cell Conditioned Medium Enhances Spinal Cord Injury Recovery via PI3K/AKT-Mediated Neuronal Apoptosis Suppression
Epidermal Neural Crest Stem Cell Conditioned Medium Enhances Spinal Cord Injury Recovery via PI3K/AKT-Mediated Neuronal Apoptosis Suppression
This study aimed to assess the impact of conditioned medium from epidermal neural crest stem cells (EPI-NCSCs-CM) on funct...
LINC00894 Regulates Cerebral Ischemia/Reperfusion Injury by Stabilizing EIF5 and Facilitating ATF4-Mediated Induction of FGF21 and ACOD1 Expression
LINC00894 Regulates Cerebral Ischemia/Reperfusion Injury by Stabilizing EIF5 and Facilitating ATF4-Mediated Induction of FGF21 and ACOD1 Expression
The non-coding RNA LINC00894 modulates tumor proliferation and drug resistance. However, its role in brain is still unclea...
Propofol Protects the Blood-Brain Barrier After Traumatic Brain Injury by Stabilizing the Extracellular Matrix via Prrx1: From Neuroglioma to Neurotrauma
Propofol Protects the Blood-Brain Barrier After Traumatic Brain Injury by Stabilizing the Extracellular Matrix via Prrx1: From Neuroglioma to Neurotrauma
The purpose of this study is to explore the shared molecular pathogenesis of traumatic brain injury (TBI) and high-grade g...
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