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Mesenchymal Stem Cell–Originated Exosomal Lnc A2M-AS1 Alleviates Hypoxia/Reperfusion-Induced Apoptosis and Oxidative Stress in Cardiomyocytes
Mesenchymal Stem Cell–Originated Exosomal Lnc A2M-AS1 Alleviates Hypoxia/Reperfusion-Induced Apoptosis and Oxidative Stress in Cardiomyocytes
Mesenchymal stem cell (MSC)-derived exosomes play significant roles in ameliorating cardiac damage after myocardial ischem...
Simvastatin, but Not Atorvastatin, Is Associated with Higher Peak Rivaroxaban Serum Levels and Bleeding: an Asian Cohort Study from Singapore
Simvastatin, but Not Atorvastatin, Is Associated with Higher Peak Rivaroxaban Serum Levels and Bleeding: an Asian Cohort Study from Singapore
This study attempts to identify predictors associated with bleeding and stroke and systemic embolism (SSE) in Singaporean ...
Long-term Dexamethasone Treatment Increases Cardiac Galectin-3 Levels
Long-term Dexamethasone Treatment Increases Cardiac Galectin-3 Levels
Glucocorticoids, which are widely prescribed around the world, cause cardiac remodeling in long-term treatment by triggeri...
Platelet-Mediated Transfer of Cardioprotection by Remote Ischemic Conditioning and Its Abrogation by Aspirin But Not by Ticagrelor
Platelet-Mediated Transfer of Cardioprotection by Remote Ischemic Conditioning and Its Abrogation by Aspirin But Not by Ticagrelor
The role of platelets during myocardial ischemia/reperfusion (I/R) is ambivalent. They contribute to injury but also to ca...
Trimetazidine to Reduce Myocardial Fibrosis—Competing Interests with SGLT2 Inhibitors?
Trimetazidine to Reduce Myocardial Fibrosis—Competing Interests with SGLT2 Inhibitors?
Qian G, Xin A, Jiang X, et al. Early trimetazidine therapy in patients undergoing primary percutaneous coronary interventi...
Long Non-coding RNA Involved in the Pathophysiology of Atrial Fibrillation
Long Non-coding RNA Involved in the Pathophysiology of Atrial Fibrillation
Atrial fibrillation (AF) is a prevalent and chronic cardiovascular disorder associated with various pathophysiological alt...
Minimal Adherence Threshold to Non-Vitamin K Antagonist Oral Anticoagulants in Patients with Atrial Fibrillation to Reduce the Risk of Thromboembolism and Death: A Nationwide Cohort Study
Minimal Adherence Threshold to Non-Vitamin K Antagonist Oral Anticoagulants in Patients with Atrial Fibrillation to Reduce the Risk of Thromboembolism and Death: A Nationwide Cohort Study
Poor adherence to non-vitamin K antagonist oral anticoagulants (NOACs) may raise thromboembolic risks in patients with atr...
Evaluation of the Efficacy of Sacubitril/Valsartan on Radiofrequency Ablation in Patients with Hypertension and Persistent Atrial Fibrillation
Evaluation of the Efficacy of Sacubitril/Valsartan on Radiofrequency Ablation in Patients with Hypertension and Persistent Atrial Fibrillation
To evaluate whether the effect of radiofrequency ablation can be improved by using sacubitril/valsartan (S/V) to control b...
A Novel Parallel Wire-based Antegrade Dissection Re-entry Technique for Failed Retrograde Attempt of Coronary Chronic Total Occlusions with Risk Nomogram Analysis
A Novel Parallel Wire-based Antegrade Dissection Re-entry Technique for Failed Retrograde Attempt of Coronary Chronic Total Occlusions with Risk Nomogram Analysis
Rapid development in coronary chronic total occlusion (CTO) interventional techniques and devices have achieved a greater ...
Effects of Rhythm Control for Atrial Fibrillation on Cardiac Remodeling and Valvular Regurgitation in Patients with Heart Failure
Effects of Rhythm Control for Atrial Fibrillation on Cardiac Remodeling and Valvular Regurgitation in Patients with Heart Failure
Previous studies investigating cardiac remodeling and functional regurgitation of rhythm control for atrial fibrillation (...
Pulmonary Circulation Under Pressure: Pathophysiological and Therapeutic Implications of BK Channel
Pulmonary Circulation Under Pressure: Pathophysiological and Therapeutic Implications of BK Channel
The large-conductance Ca2+-activated K+ (BK) channel is widely expressed in the pulmonary blood vessels and plays a signif...
Exercise Prevents Glucocorticoid-Induced Myocardial 4-Hydroxynonenal Production
Exercise Prevents Glucocorticoid-Induced Myocardial 4-Hydroxynonenal Production
Long-term administration of glucocorticoids (GCs) increases myocardial oxidative stress. 4-Hydroxynonenal (4-HNE) protein ...
Does Genotype Affect the Efficacy of PCSK9 Inhibitors in the Treatment of Familial Hypercholesterolemia?
Does Genotype Affect the Efficacy of PCSK9 Inhibitors in the Treatment of Familial Hypercholesterolemia?
This review discusses whether patients’ genotype affects the efficacy of PCSK9 inhibitors in treating familial hyper...
PDHA1 Alleviates Myocardial Ischemia-Reperfusion Injury by Improving Myocardial Insulin Resistance During Cardiopulmonary Bypass Surgery in Rats
PDHA1 Alleviates Myocardial Ischemia-Reperfusion Injury by Improving Myocardial Insulin Resistance During Cardiopulmonary Bypass Surgery in Rats
Cardiopulmonary bypass (CPB) is a requisite technique for thoracotomy in advanced cardiovascular surgery. However, the con...
High BMI: Another Barrier to Rapid Platelet Inhibition After STEMI PCI
High BMI: Another Barrier to Rapid Platelet Inhibition After STEMI PCI
Lawton JS, Tamis-Holland JE, Bangalore S, et al. 2021 ACC/AHA/SCAI guideline for coronary artery revascularization: a repo...
Effect of Beta-Blocker on Long-Term Major Cardiovascular Events in High Atherosclerotic Risk Population
Effect of Beta-Blocker on Long-Term Major Cardiovascular Events in High Atherosclerotic Risk Population
Beta-blocker is a frequently used medication in cardiovascular diseases. However, long-term benefit of beta-blocker in pat...
US Population Eligibility and Estimated Impact of Semaglutide Treatment on Obesity Prevalence and Cardiovascular Disease Events
US Population Eligibility and Estimated Impact of Semaglutide Treatment on Obesity Prevalence and Cardiovascular Disease Events
Semaglutide 2.4 mg benefits weight loss and reduction of cardiovascular disease (CVD) risk factors in adults with...
Antiphospholipid Syndrome: State of the Art of Clinical Management
Antiphospholipid Syndrome: State of the Art of Clinical Management
Antiphospholipid syndrome (APS) is a systemic autoimmune disorder clinically characterized by recurrent arterial and venou...
Beneficial Effects of Angiotensin II Receptor Blockers on Mortality in Patients with COVID-19: A Retrospective Study from 2019 to 2020 in China
Beneficial Effects of Angiotensin II Receptor Blockers on Mortality in Patients with COVID-19: A Retrospective Study from 2019 to 2020 in China
The COVID-19 pandemic has become a serious global public health problem. Although the use of angiotensin-converting enzyme...
Iron Status Screening in Individuals with Heart Failure Before Initiating Sodium-Glucose Cotransporter 2 Inhibitor Therapy: Is It Necessary?
Iron Status Screening in Individuals with Heart Failure Before Initiating Sodium-Glucose Cotransporter 2 Inhibitor Therapy: Is It Necessary?
Packer M. SGLT2 inhibitors: role in protective reprogramming of cardiac nutrient transport and metabolism. Nature Reviews ...
Direct Oral Anticoagulants: Navigating Through Clinical Challenges
Direct Oral Anticoagulants: Navigating Through Clinical Challenges
Direct oral anticoagulants (DOACs) have been approved, for over a decade, by both European and American medicine agencies,...
Mutant CYP3A4/5 Correlated with Clinical Outcomes by Affecting Rivaroxaban Pharmacokinetics and Pharmacodynamics in Patients with Atrial Fibrillation
Mutant CYP3A4/5 Correlated with Clinical Outcomes by Affecting Rivaroxaban Pharmacokinetics and Pharmacodynamics in Patients with Atrial Fibrillation
This study was designed to investigate the impact of single-nucleotide polymorphism-encoded cytochrome P450 enzymes (CYP3A...
The Effect of Hydroxychloroquine on Cardiovascular Disease in Patients with Rheumatoid Arthritis
The Effect of Hydroxychloroquine on Cardiovascular Disease in Patients with Rheumatoid Arthritis
We read with great interest the article entitled “Hydroxychloroquine and Cardiovascul...
Treatment and Prophylaxis of Post-pericardiotomy Syndrome in Cardiac Surgery Patients: a Systematic Review
Treatment and Prophylaxis of Post-pericardiotomy Syndrome in Cardiac Surgery Patients: a Systematic Review
Post-pericardiotomy syndrome (PPS) is a common complication of cardiac surgery. This systematic review aimed to investigat...
P2Y12 Inhibitors in STEMI Patients — One Size Does Not Fit All
P2Y12 Inhibitors in STEMI Patients — One Size Does Not Fit All
Ibanez B, James S, Agewall S, et al. 2017 ESC Guidelines for the management of acute myocardial infarction in patients pre...
Preliminary Study on Retrograde Recanalization of Radial Artery Occlusion Through Distal Radial Artery Access: a Single-Center Experience
Preliminary Study on Retrograde Recanalization of Radial Artery Occlusion Through Distal Radial Artery Access: a Single-Center Experience
Radial artery occlusion (RAO) is an unresolved complication after transradial artery (TRA) puncture. The aim of this obser...
Advances in MicroRNA Therapy for Heart Failure: Clinical Trials, Preclinical Studies, and Controversies
Advances in MicroRNA Therapy for Heart Failure: Clinical Trials, Preclinical Studies, and Controversies
Heart failure (HF) is a rapidly growing public health issue with more than 37.7 million patients worldwide and an annual h...
Who Should Be the Corresponding Author, What Are Their Responsibilities, and What Email Address Should They Provide?
Who Should Be the Corresponding Author, What Are Their Responsibilities, and What Email Address Should They Provide?
The essential and major goal for scientific researchers has been, and will be, to pub...
Netrin-1 and RGMa: Novel Regulators of Atherosclerosis-Related Diseases
Netrin-1 and RGMa: Novel Regulators of Atherosclerosis-Related Diseases
Neuronal guidance proteins (NGPs) have been demonstrated to guide the elongation of neuronal axonal grow...
Poking and Prodding So They Take Their Pills
Poking and Prodding So They Take Their Pills
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