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Are Sodium-Glucose Cotransporter-2 Inhibitors the Cherry on Top of Cardio-Oncology Care?
Are Sodium-Glucose Cotransporter-2 Inhibitors the Cherry on Top of Cardio-Oncology Care?
The increasing aging of the population combined with improvements in cancer detection and care has significantly improved ...
Reducing Cardiovascular Disease—An Alternative Approach
Reducing Cardiovascular Disease—An Alternative Approach
Statin drugs are effective at reducing cardiovascular events, but adherence to statin therapy remains a problem for patien...
Long-Term Stimulation of the Left Dorsal Branch of the Thoracic Nerve Improves Ventricular Electrical Remodeling in a Canine Model of Chronic Myocardial Infarction
Long-Term Stimulation of the Left Dorsal Branch of the Thoracic Nerve Improves Ventricular Electrical Remodeling in a Canine Model of Chronic Myocardial Infarction
To evaluate the ventricular electrophysiologic effects of long-term stimulation of the left dorsal branch of thoracic nerv...
Methodological Quality of Pulmonary Arterial Hypertension Treatment Evidence-Based Guidelines: A Systematic Review Using the AGREE II and AGREE REX Tools
Methodological Quality of Pulmonary Arterial Hypertension Treatment Evidence-Based Guidelines: A Systematic Review Using the AGREE II and AGREE REX Tools
Pulmonary arterial hypertension (PAH) is a progressive disease with a poor prognosis, and its management should be grounde...
Off-pump Versus On-pump Coronary Artery Bypass Grafting in Diabetic patients: A Meta-analysis of Observational Studies with a Propensity-Score Analysis
Off-pump Versus On-pump Coronary Artery Bypass Grafting in Diabetic patients: A Meta-analysis of Observational Studies with a Propensity-Score Analysis
The debate between off-pump coronary artery bypass grafting (OPCAB) and on-pump coronary artery bypass grafting (ONCAB) in...
Immunotherapy in the Context of Aortic Valve Diseases
Immunotherapy in the Context of Aortic Valve Diseases
Aortic valve disease (AVD) affects millions of people around the world, with no pharmacological intervention available. Wi...
Heme Oxygenase-1, Cardiac Senescence, and Myocardial Infarction: A Critical Review of the Triptych
Heme Oxygenase-1, Cardiac Senescence, and Myocardial Infarction: A Critical Review of the Triptych
Heme oxygenase-1 (HO-1) is a crucial enzyme in heme metabolism, facilitating the breakdown of heme into biliverdin, carbon...
Amplification of Cardioprotective Response of Remote Ischemic Preconditioning in Rats by Quercetin: Potential Role of Activation of mTOR-dependent Autophagy and Nrf2
Amplification of Cardioprotective Response of Remote Ischemic Preconditioning in Rats by Quercetin: Potential Role of Activation of mTOR-dependent Autophagy and Nrf2
Noninvasive remote ischemic preconditioning (RIPC) is a practical, acceptable, and feasible conditioning technique reporte...
Efficacy and Safety of Edoxaban in Anticoagulant Therapy Early After Surgical Bioprosthetic Valve Replacement: Rationale and Design of the ENBALV Trial
Efficacy and Safety of Edoxaban in Anticoagulant Therapy Early After Surgical Bioprosthetic Valve Replacement: Rationale and Design of the ENBALV Trial
Anticoagulant therapy with vitamin K antagonists is recommended within 3 to 6 months after bioprosthetic valve replacement...
PCSK9 and Lipid Metabolism: Genetic Variants, Current Therapies, and Cardiovascular Outcomes
PCSK9 and Lipid Metabolism: Genetic Variants, Current Therapies, and Cardiovascular Outcomes
Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a crucial role in the modulation of lipid metabolism as a crit...
Blocking the TRAIL-DR5 Pathway Reduces Cardiac Ischemia–Reperfusion Injury by Decreasing Neutrophil Infiltration and Neutrophil Extracellular Traps Formation
Blocking the TRAIL-DR5 Pathway Reduces Cardiac Ischemia–Reperfusion Injury by Decreasing Neutrophil Infiltration and Neutrophil Extracellular Traps Formation
Acute myocardial infarction (AMI) is a leading cause of mortality. Neutrophils penetrate injured heart tissue during AMI o...
Hydrogen Sulfide Ameliorates Heart Aging by Downregulating Matrix Metalloproteinase-9
Hydrogen Sulfide Ameliorates Heart Aging by Downregulating Matrix Metalloproteinase-9
Aging contributes significantly to cardiovascular diseases and cardiac dysfunction, leading to the upregulation of matrix ...
Immediate Versus Staged Complete Revascularization in Patients Presenting with Acute Coronary Syndrome and Multivessel Coronary Disease Without Cardiac Shock: A Study-Level Meta-analysis of Randomized Controlled Trials
Immediate Versus Staged Complete Revascularization in Patients Presenting with Acute Coronary Syndrome and Multivessel Coronary Disease Without Cardiac Shock: A Study-Level Meta-analysis of Randomized Controlled Trials
Achieving full revascularization via percutaneous coronary intervention (PCI) may enhance the prognosis of individuals dia...
A Mitochondrial Basis for Heart Failure Progression
A Mitochondrial Basis for Heart Failure Progression
In health, the human heart is able to match ATP supply and demand perfectly. It requires 6 kg of ATP per day to s...
Comparative analysis of the addition of empagliflozin versus doubling the furosemide dose in decompensated heart failure
Comparative analysis of the addition of empagliflozin versus doubling the furosemide dose in decompensated heart failure
This study aims to compare the addition of SGLT2 inhibitors or doubling the diuretic dose in patients receiving treatment ...
Insight into Cardioprotective Effects and Mechanisms of Dexmedetomidine
Insight into Cardioprotective Effects and Mechanisms of Dexmedetomidine
Cardiovascular disease remains the leading cause of death worldwide. Dexmedetomidine is a highly selective α2 adrener...
Clinical Outcomes of Early Rhythm or Rate Control for New Onset Atrial Fibrillation Following Transcatheter Aortic Valve Replacement
Clinical Outcomes of Early Rhythm or Rate Control for New Onset Atrial Fibrillation Following Transcatheter Aortic Valve Replacement
New onset atrial fibrillation (NOAF) is a common occurrence after transcatheter aortic valve replacement (TAVR) and porten...
Cardioprotection with Intralipid During Coronary Artery Bypass Grafting Surgery on Cardiopulmonary Bypass: A Randomized Clinical Trial
Cardioprotection with Intralipid During Coronary Artery Bypass Grafting Surgery on Cardiopulmonary Bypass: A Randomized Clinical Trial
Coronary artery bypass grafting (CABG) on cardiopulmonary bypass (CPB) is associated with myocardial ischemia–reperf...
Effectiveness and Safety of Direct Oral Anticoagulants Versus Warfarin in Patients with Atrial Fibrillation and Cancer: A Target Trial Emulation from SEER-Medicare Database
Effectiveness and Safety of Direct Oral Anticoagulants Versus Warfarin in Patients with Atrial Fibrillation and Cancer: A Target Trial Emulation from SEER-Medicare Database
Direct oral anticoagulants (DOACs) are preferred over warfarin in patients with atrial fibrillation (AFib). However, their...
US Population Eligibility and Estimated Impact of Tirzepatide Treatment on Obesity Prevalence and Cardiovascular Disease Events
US Population Eligibility and Estimated Impact of Tirzepatide Treatment on Obesity Prevalence and Cardiovascular Disease Events
Tirzepatide promotes weight loss and reduces risk factors for cardiovascular disease (CVD) in adults with overwei...
Enhanced Reendothelialization and Thrombosis Prevention with a New Drug-Eluting Stent
Enhanced Reendothelialization and Thrombosis Prevention with a New Drug-Eluting Stent
The objective of the study is to test the efficacy of cyclopentenyl cytosine (CPEC)-coated stents on blocking artery steno...
Mitogen-Activated Protein Kinases Mediate Adventitial Fibroblast Activation and Neointima Formation via GATA4/Cyclin D1 Axis
Mitogen-Activated Protein Kinases Mediate Adventitial Fibroblast Activation and Neointima Formation via GATA4/Cyclin D1 Axis
Activation of mitogen-activated protein kinases (MAPKs) by pathological stimuli participates in cardiovascular diseases. D...
Comparative Muscle Tolerability of Different Types and Intensities of Statins: A Network Meta-Analysis of Double-Blind Randomized Controlled Trials
Comparative Muscle Tolerability of Different Types and Intensities of Statins: A Network Meta-Analysis of Double-Blind Randomized Controlled Trials
The benefits of statins for ischemic cardio-cerebrovascular diseases are well known. However, concerns around muscle adver...
The Association of Proton Pump Inhibitors and QT Interval Prolongation in Critically Ill Patients
The Association of Proton Pump Inhibitors and QT Interval Prolongation in Critically Ill Patients
Drug-induced QT interval prolongation has been reported to be related to life-threatening polymorphic ventricular tachycar...
Rationale and Design of Prospective, Multicenter, Double-Arm Clinical Trial to Investigate the Efficacy of Tofogliflozin on Left Ventricular Diastolic Dysfunction in Patients with Heart Failure with Preserved Ejection Fraction and Type 2 Diabetes Mellitus (TOP-HFPEF Trial)
Rationale and Design of Prospective, Multicenter, Double-Arm Clinical Trial to Investigate the Efficacy of Tofogliflozin on Left Ventricular Diastolic Dysfunction in Patients with Heart Failure with Preserved Ejection Fraction and Type 2 Diabetes Mellitus (TOP-HFPEF Trial)
Recent large clinical trials have revealed that sodium–glucose cotransporter 2 (SGLT2) inhibitors improve cardiovasc...
LncRNA Gm15834 Aggravates Cardiac Hypertrophy by Interacting with Sam68 and Activating NF-κB Mediated Inflammation
LncRNA Gm15834 Aggravates Cardiac Hypertrophy by Interacting with Sam68 and Activating NF-κB Mediated Inflammation
Cardiac hypertrophy is the common pathological process of multiple cardiovascular diseases. However, the molecular mechani...
miR-210-5p Promotes Pulmonary Hypertension by Blocking ATP2A2
miR-210-5p Promotes Pulmonary Hypertension by Blocking ATP2A2
Aberrant expression of ATPase sarcoplasmic/endoplasmic retic Ca2+ transporting 2 (ATP2A2) has attracted attention fo...
Outcomes With Hybrid Catheter-Directed Therapy Compared With Aspiration Thrombectomy for Patients With Intermediate-High Risk Pulmonary Embolism
Outcomes With Hybrid Catheter-Directed Therapy Compared With Aspiration Thrombectomy for Patients With Intermediate-High Risk Pulmonary Embolism
Intermediate-high-risk pulmonary embolism (IHR PE) is a challenging form of embolism obstruction that causes right ventric...
Impairment of Vascular Homeostasis in Acute Heart Failure: Enter the Monocyte?
Impairment of Vascular Homeostasis in Acute Heart Failure: Enter the Monocyte?
The stimulus for this Editorial Comment was provided by the recent publication in Cardiovascular Drugs and Therapy of an o...
Gab1 Overexpression Attenuates Susceptibility to Ventricular Arrhythmias in Pressure Overloaded Heart Failure Mouse Hearts
Gab1 Overexpression Attenuates Susceptibility to Ventricular Arrhythmias in Pressure Overloaded Heart Failure Mouse Hearts
Grb2 associated binding protein 1 (Gab1) is an adaptor protein that is important for intracellular signal transduction whi...
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