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The Acid Sphingomyelinase Inhibitor Amitriptyline Ameliorates TNF-α-Induced Endothelial Dysfunction
The Acid Sphingomyelinase Inhibitor Amitriptyline Ameliorates TNF-α-Induced Endothelial Dysfunction
Inflammation associated endothelial cell (EC) dysfunction is key to atherosclerotic disease. Recent studies have demonstra...
Efficacy and Safety of Omega-3 Fatty Acids in the Prevention of Cardiovascular Disease: A Systematic Review and Meta-analysis
Efficacy and Safety of Omega-3 Fatty Acids in the Prevention of Cardiovascular Disease: A Systematic Review and Meta-analysis
It is widely accepted that omega-3 fatty acids are beneficial in the prevention of cardiovascular disease, but many large ...
The Effects of Dexamethasone on Cardiovascular Disease: Friend or Foe?
The Effects of Dexamethasone on Cardiovascular Disease: Friend or Foe?
Akin S, Gucuk-Ipek E, Hayta U, et al. Long-term dexamethasone treatment increases cardiac galectin-3 levels. Cardiovasc Dr...
A Comprehensive Review of the Pleiotropic Effects of Ticagrelor
A Comprehensive Review of the Pleiotropic Effects of Ticagrelor
This review summarizes the findings of preclinical studies evaluating the pleiotropic effects of ticagrelor. These include...
Influence of Genetic and Epigenetic Factors of P2Y12 Receptor on the Safety and Efficacy of Antiplatelet Drugs
Influence of Genetic and Epigenetic Factors of P2Y12 Receptor on the Safety and Efficacy of Antiplatelet Drugs
P2Y12 receptor inhibitors are drugs that decrease the risk of stent thrombosis and lower the long-term risk of non-stent-r...
SGLT2-Inhibitors on HFpEF Patients. Role of Ejection Fraction
SGLT2-Inhibitors on HFpEF Patients. Role of Ejection Fraction
Results from DELIVER trial and publication of EMPEROR-Preserved with sodium-glucose cotransporter 2 (SGLT2) inhibitors in ...
Nicorandil Suppresses Ischemia-Induced Norepinephrine Release and Ventricular Arrhythmias in Hypertrophic Hearts
Nicorandil Suppresses Ischemia-Induced Norepinephrine Release and Ventricular Arrhythmias in Hypertrophic Hearts
Ventricular arrhythmias (VAs) are a common cause of sudden death in acute myocardial infarction (MI), for which hypertensi...
Colchicine Inhibits NETs and Alleviates Cardiac Remodeling after Acute Myocardial Infarction
Colchicine Inhibits NETs and Alleviates Cardiac Remodeling after Acute Myocardial Infarction
Colchicine, a multipotent anti-inflammatory drug, has been reported to alleviate cardiac remodeling and improve cardiac fu...
Functional and Metabolic Imaging in Heart Failure with Preserved Ejection Fraction: Promises, Challenges, and Clinical Utility
Functional and Metabolic Imaging in Heart Failure with Preserved Ejection Fraction: Promises, Challenges, and Clinical Utility
Heart failure with preserved ejection fraction (HFpEF) is recognised as an increasingly prevalent, morbid and burdensome c...
Antiplatelet Therapy in End-stage Renal Disease Patients on Maintenance Dialysis: a State-of-the-art Review
Antiplatelet Therapy in End-stage Renal Disease Patients on Maintenance Dialysis: a State-of-the-art Review
Patients with end-stage renal disease (ESRD) on maintenance dialysis have an increased risk of ischaemic events, such as r...
Evolving Roles of Optimal Medical Therapy and PCI in Chronic Coronary Syndrome Patients with Stable Angina: Introduction
Evolving Roles of Optimal Medical Therapy and PCI in Chronic Coronary Syndrome Patients with Stable Angina: Introduction
This Introduction sets the stage for 5 subsequent papers that will follow, and which describe several key features of the ...
Berberine Reverses Nitroglycerin Tolerance through Suppressing Protein Kinase C Alpha Activity in Vascular Smooth Muscle Cells
Berberine Reverses Nitroglycerin Tolerance through Suppressing Protein Kinase C Alpha Activity in Vascular Smooth Muscle Cells
The aim of this study was to evaluate the effects of berberine on nitroglycerin (NTG) tolerance and explore the underlying...
NF-κB, A Potential Therapeutic Target in Cardiovascular Diseases
NF-κB, A Potential Therapeutic Target in Cardiovascular Diseases
Cardiovascular diseases (CVDs) are the leading cause of death globally. Atherosclerosis is the basis of major CVDs –...
Low-dose Dasatinib Ameliorates Hypertrophic Cardiomyopathy in Noonan Syndrome with Multiple Lentigines
Low-dose Dasatinib Ameliorates Hypertrophic Cardiomyopathy in Noonan Syndrome with Multiple Lentigines
Noonan syndrome with multiple lentigines (NSML) is an autosomal dominant disorder presenting with hypertrophic cardiomyopa...
Innovations in Cardiac Implantable Electronic Devices
Innovations in Cardiac Implantable Electronic Devices
Cardiac implantable electronic devices (CIEDs) are essential for the management of a variety of cardiac conditions, includ...
Chronic Oral Anticoagulation and Clinical Outcome in Hospitalized COVID-19 Patients
Chronic Oral Anticoagulation and Clinical Outcome in Hospitalized COVID-19 Patients
The clinical course of COVID-19 may be complicated by acute respiratory distress syndrome (ARDS) and thromboembolic events...
Empagliflozin Disrupts a Tnfrsf12a-Mediated Feed Forward Loop That Promotes Left Ventricular Hypertrophy
Empagliflozin Disrupts a Tnfrsf12a-Mediated Feed Forward Loop That Promotes Left Ventricular Hypertrophy
Although the cardioprotective benefits of sodium-glucose cotransporter 2 (SGLT2) inhibitors are now widely appreciated, th...