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Butyrate-Mediated Modulation of Paraoxonase-1 Alleviates Cardiorenometabolic Abnormalities in a Rat Model of Polycystic Ovarian Syndrome
Butyrate-Mediated Modulation of Paraoxonase-1 Alleviates Cardiorenometabolic Abnormalities in a Rat Model of Polycystic Ovarian Syndrome
Polycystic ovarian syndrome (PCOS) has been associated with cardiovascular risks and comorbid pathologies, particularly ca...
Ticagrelor versus Clopidogrel: Two Controversial Drugs in Patients with Acute Coronary Syndrome
Ticagrelor versus Clopidogrel: Two Controversial Drugs in Patients with Acute Coronary Syndrome
Yan Y, Xu H, Zhao Y, Lin S, Zheng Y. Ticagrelor versus clopidogrel in patients with left main coronary artery stenting. Ca...
Kirenol Ameliorates Myocardial Ischemia–Reperfusion Injury by Promoting Mitochondrial Function and Inhibiting Inflammasome Activation
Kirenol Ameliorates Myocardial Ischemia–Reperfusion Injury by Promoting Mitochondrial Function and Inhibiting Inflammasome Activation
Macrophage-mediated inflammation plays a crucial role in the pathophysiological process of myocardial ischemia/reperfusion...
Associations of SGLT2i with Cardiorenal Outcomes Among Diabetics with Prostate Cancer on Hormone Therapy
Associations of SGLT2i with Cardiorenal Outcomes Among Diabetics with Prostate Cancer on Hormone Therapy
Studies have reported associations between prostate cancer, type II diabetes mellitus (T2DM), and cardiovascular disease i...
The Incidence of Contrast-Induced Nephropathy in Patients on Sodium-Glucose Cotransporter-2 Inhibitors Following Percutaneous Coronary Intervention: An Observational Analysis
The Incidence of Contrast-Induced Nephropathy in Patients on Sodium-Glucose Cotransporter-2 Inhibitors Following Percutaneous Coronary Intervention: An Observational Analysis
The purpose of this study is to compare the incidence of contrast-induced nephropathy (CIN) following percutaneous coronar...
AGE-RAGE Axis and Cardiovascular Diseases: Pathophysiologic Mechanisms and Prospects for Clinical Applications
AGE-RAGE Axis and Cardiovascular Diseases: Pathophysiologic Mechanisms and Prospects for Clinical Applications
Advanced glycation end products (AGE), a diverse array of molecules generated through non-enzymatic glycosylation, in conj...
Epicardial Adipocytes in Cardiac Pathology and Healing
Epicardial Adipocytes in Cardiac Pathology and Healing
Implications of epicardial adipose tissue (EAT) on the development of coronary artery disease (CAD) have garnered recent a...
Clinical Efficacy and Safety of Novel Anticoagulants for the Management of Venous Thromboembolism in Patients with Cancer: A Systematic Review and Meta-Analysis
Clinical Efficacy and Safety of Novel Anticoagulants for the Management of Venous Thromboembolism in Patients with Cancer: A Systematic Review and Meta-Analysis
Cancer patients face a four- to sevenfold higher risk of venous thromboembolism (VTE) than the general population. Novel o...
Acute Inhibition of Drp1 Mitigates Adverse Cardiac Remodelling following Chronic Reperfused Myocardial Infarction
Acute Inhibition of Drp1 Mitigates Adverse Cardiac Remodelling following Chronic Reperfused Myocardial Infarction
Baker Heart and Diabetes Institute, Melbourne, Victoria, 3004, AustraliaDaniel G. Donner, Helen Kiriazis, Aascha Brown &am...
Ticagrelor versus Clopidogrel in Patients with left main Coronary Artery Stenting
Ticagrelor versus Clopidogrel in Patients with left main Coronary Artery Stenting
The left main (LM) coronary artery disease poses high risks for its special anatomical characteristics. Optimal antiplatel...
Effect of Statin Treatment on Lipoprotein-Associated Phospholipase A2 Mass and Activity: A Systematic Review and Meta-analysis of Randomized Placebo-Controlled Trials
Effect of Statin Treatment on Lipoprotein-Associated Phospholipase A2 Mass and Activity: A Systematic Review and Meta-analysis of Randomized Placebo-Controlled Trials
The goal of this meta-analysis was to establish whether statin treatment reduces Lp-PLA2 mass concentration and/or activit...
Epigallocatechin-3-Gallate Inhibits Atrial Fibrosis and Reduces the Occurrence and Maintenance of Atrial Fibrillation and its Possible Mechanisms
Epigallocatechin-3-Gallate Inhibits Atrial Fibrosis and Reduces the Occurrence and Maintenance of Atrial Fibrillation and its Possible Mechanisms
Atrial fibrosis is one of the main causes of the onset and recurrence of atrial fibrillation (AF), for which there is no e...
Acute and Post-Acute COVID-19 Cardiovascular Complications: A Comprehensive Review
Acute and Post-Acute COVID-19 Cardiovascular Complications: A Comprehensive Review
The risk of cardiovascular complications due to SARS-CoV-2 are significantly increased within the first 6 months of the in...
Regulatory T Cells in Pathological Cardiac Hypertrophy: Mechanisms and Therapeutic Potential
Regulatory T Cells in Pathological Cardiac Hypertrophy: Mechanisms and Therapeutic Potential
Pathological cardiac hypertrophy is linked to immune-inflammatory injury, and regulatory T cells (Tregs) play a crucial ro...
Research progress on the therapeutic effects of nanoparticles loaded with drugs against atherosclerosis
Research progress on the therapeutic effects of nanoparticles loaded with drugs against atherosclerosis
Presently, there are many drugs for the treatment of atherosclerosis (AS), among which lipid-lowering, anti-inflammatory, ...
Effect of Prolonged Use of Dronedarone on Recurrence in Patients with Non-Paroxysmal Atrial Fibrillation After Radiofrequency Ablation (DORIS): Rationale and Design of a Randomized Multicenter, Double-Blinded Placebo-Controlled Trial
Effect of Prolonged Use of Dronedarone on Recurrence in Patients with Non-Paroxysmal Atrial Fibrillation After Radiofrequency Ablation (DORIS): Rationale and Design of a Randomized Multicenter, Double-Blinded Placebo-Controlled Trial
Prolonged use of anti-arrhythmic drugs (AAD) beyond the post-ablation blanking period to maintain sinus rhythm has been ad...
Pharmacological Inhibition of P-Rex1/Rac1 Axis Blocked Angiotensin II-Induced Cardiac Fibrosis
Pharmacological Inhibition of P-Rex1/Rac1 Axis Blocked Angiotensin II-Induced Cardiac Fibrosis
Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor-1 (P-Rex1), as one of the members of Rac-GEFs, has ...
Meta-Analysis Evaluating Risk of Hyperkalemia Stratified by Baseline MRA Usage in Patients with Heart Failure Receiving SGLT2 Inhibitors
Meta-Analysis Evaluating Risk of Hyperkalemia Stratified by Baseline MRA Usage in Patients with Heart Failure Receiving SGLT2 Inhibitors
Both mineralocorticoid receptor antagonists (MRAs) and sodium-glucose co-transporter type 2 inhibitors (SGLT2is) have demo...
Comparative Study Between the Effects of High Doses of Rosuvastatin and Atorvastatin on Ventricular Remodeling in Patients with ST-Segment Elevation Myocardial Infarction
Comparative Study Between the Effects of High Doses of Rosuvastatin and Atorvastatin on Ventricular Remodeling in Patients with ST-Segment Elevation Myocardial Infarction
Most studies reported that treating ST-Elevation Myocardial Infarction (STEMI) patients with high doses of rosuvastatin or...
Risk of Suicide, Hair Loss, and Aspiration with GLP1-Receptor Agonists and Other Diabetic Agents: A Real-World Pharmacovigilance Study
Risk of Suicide, Hair Loss, and Aspiration with GLP1-Receptor Agonists and Other Diabetic Agents: A Real-World Pharmacovigilance Study
With the increasing popularity of glucagon-like peptide 1 receptor agonists (GLP1-RAs), numerous safety concerns arose per...
Clopidogrel: Drug of the Past or Drug of the Future?
Clopidogrel: Drug of the Past or Drug of the Future?
The Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators. Effects of clopidogrel in addition to ...
Comparison of Ticagrelor with Clopidogrel on Coronary Microvascular Dysfunction Following Acute Myocardial Infarction Using Angiography-Derived Index of Microcirculatory Resistance
Comparison of Ticagrelor with Clopidogrel on Coronary Microvascular Dysfunction Following Acute Myocardial Infarction Using Angiography-Derived Index of Microcirculatory Resistance
This research aimed to assess the impact of ticagrelor and clopidogrel on coronary microvascular dysfunction (CMD) and pro...
Low Thyroid Hormones Level Attenuates Mitochondrial Dysfunction and Right Ventricular Failure in Pulmonary Hypertensive Rats
Low Thyroid Hormones Level Attenuates Mitochondrial Dysfunction and Right Ventricular Failure in Pulmonary Hypertensive Rats
This study is to investigate the repercussions of hypothyroidism in the pathophysiological progression of pulmonary arteri...
Comparative Efficacy of Colchicine and Intensive Low-density Lipoprotein Cholesterol Lowering in Patients with Atherosclerotic Diseases receiving Statins: A Network Meta-analysis of Randomized Controlled Trials
Comparative Efficacy of Colchicine and Intensive Low-density Lipoprotein Cholesterol Lowering in Patients with Atherosclerotic Diseases receiving Statins: A Network Meta-analysis of Randomized Controlled Trials
Adding intensive low-density lipoprotein cholesterol (LDL-C)-lowering agents or colchicine to statin has been shown to res...
Efficacy and Safety of Non-Vitamin K Antagonist Oral Anticoagulants Compared with Vitamin K Antagonists in Patients with Atrial Fibrillation and Type 2 Valvular Heart Disease: A Systematic Review and Meta-Analysis
Efficacy and Safety of Non-Vitamin K Antagonist Oral Anticoagulants Compared with Vitamin K Antagonists in Patients with Atrial Fibrillation and Type 2 Valvular Heart Disease: A Systematic Review and Meta-Analysis
This meta-analysis aimed to evaluate the efficacy and safety of non-vitamin K antagonist oral anticoagulants (NOACs) compa...
Effect of Preoperative Mitral Regurgitation on LVAD Outcomes in Patients with Elevated Pulmonary Vascular Resistance
Effect of Preoperative Mitral Regurgitation on LVAD Outcomes in Patients with Elevated Pulmonary Vascular Resistance
In patients with end-stage heart failure who undergo left ventricular assist device (LVAD) implantation, higher pulmonary ...
Exercise Enhances Anti-contractile Effects of PVAT Through Endogenous H2S in High-Fat Diet–Induced Obesity Hypertension
Exercise Enhances Anti-contractile Effects of PVAT Through Endogenous H2S in High-Fat Diet–Induced Obesity Hypertension
Hydrogen sulfide (H2S) secreted by perivascular adipose tissue (PVAT) is a critical vasodilator, which might be involved d...
Levosimendan Reverses Cardiac Malfunction and Cardiomyocyte Ferroptosis During Heart Failure with Preserved Ejection Fraction via Connexin 43 Signaling Activation
Levosimendan Reverses Cardiac Malfunction and Cardiomyocyte Ferroptosis During Heart Failure with Preserved Ejection Fraction via Connexin 43 Signaling Activation
In recent decades, the occurrence of heart failure with preserved ejection fraction (HFpEF) has outweighed that of heart f...
Third-Generation Sirolimus‐Eluting Bioresorbable Tyrocore Scaffold Implantation in Patients with ST‐Segment Elevation Myocardial Infarction: Baseline and 6-Month OCT and Clinical Outcomes—a FANTOM STEMI Pilot Study
Third-Generation Sirolimus‐Eluting Bioresorbable Tyrocore Scaffold Implantation in Patients with ST‐Segment Elevation Myocardial Infarction: Baseline and 6-Month OCT and Clinical Outcomes—a FANTOM STEMI Pilot Study
The aim of this study was to evaluate the safety and efficacy of the Fantom BRS 6 months after implantation using...
Levosimendan: A New Therapeutical Strategy in Patients with Renal Insufficiency
Levosimendan: A New Therapeutical Strategy in Patients with Renal Insufficiency
Levosimendan, a Ca2 + sensitizer with positive inotropic effects, is primarily employed for the short-term tre...
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