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Acid-sensing ion channel 1a exacerbates renal ischemia–reperfusion injury through the NF-κB/NLRP3 inflammasome pathway
Acid-sensing ion channel 1a exacerbates renal ischemia–reperfusion injury through the NF-κB/NLRP3 inflammasome pathway
Ischemia-reperfusion injury (IRI) is the main cause of acute kidney injury (AKI), and there is no effective therapy. Micro...
Acid sphingomyelinase expression is associated with survival in resectable pancreatic ductal adenocarcinoma
Acid sphingomyelinase expression is associated with survival in resectable pancreatic ductal adenocarcinoma
Pancreatic adenocarcinoma (PDAC) is one of the most common cancers worldwide. Unfortunately, the prognosis of PDAC is rath...
Transcriptional changes in multiple endocrine organs from lethal cases of COVID-19
Transcriptional changes in multiple endocrine organs from lethal cases of COVID-19
Altered circulating hormone and metabolite levels have been reported during and post-COVID-19. Yet, studies of gene expres...
Modulation of cellular transcriptome and proteome composition by azidohomoalanine—implications on click chemistry–based secretome analysis
Modulation of cellular transcriptome and proteome composition by azidohomoalanine—implications on click chemistry–based secretome analysis
The analysis of the secretome provides important information on proteins defining intercellular communication and the recr...
Loss of CAA interruption and intergenerational CAG instability in Chinese patients with Huntington’s disease
Loss of CAA interruption and intergenerational CAG instability in Chinese patients with Huntington’s disease
Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder caused by CAG expansions in huntingtin...
Dysregulation of miRNA-30e-3p targeting IL-1β in an international cohort of systemic autoinflammatory disease patients
Dysregulation of miRNA-30e-3p targeting IL-1β in an international cohort of systemic autoinflammatory disease patients
Autoinflammation is the standard mechanism seen in systemic autoinflammatory disease (SAID) patients. This study aimed to ...
Dispensable role of Rac1 and Rac3 after cochlear hair cell specification
Dispensable role of Rac1 and Rac3 after cochlear hair cell specification
Rac small GTPases play important roles during embryonic development of the inner ear; however, little is known regarding t...
Mitochondrial transplantation as a possible therapeutic option for sarcopenia
Mitochondrial transplantation as a possible therapeutic option for sarcopenia
With advancing age, the skeletal muscle phenotype is characterized by a progressive loss of mass, strength, and quality. T...
The TLR/MyD88 signalling cascade in inflammation and gastric cancer: the immune regulatory network of Helicobacter pylori
The TLR/MyD88 signalling cascade in inflammation and gastric cancer: the immune regulatory network of Helicobacter pylori
Helicobacter pylori-induced chronic gastritis represents a well-established risk factor for gastric cancer (GC). However, ...
LAMP2A regulates the balance of mesenchymal stem cell adipo-osteogenesis via the Wnt/β-catenin/GSK3β signaling pathway
LAMP2A regulates the balance of mesenchymal stem cell adipo-osteogenesis via the Wnt/β-catenin/GSK3β signaling pathway
Chaperone-mediated autophagy (CMA) plays multiple roles in cell metabolism. We found that lysosome-associated membrane pro...
Bicuspid aortic valve aortopathy is characterized by embryonic epithelial to mesenchymal transition and endothelial instability
Bicuspid aortic valve aortopathy is characterized by embryonic epithelial to mesenchymal transition and endothelial instability
Bicuspid aortic valve (BAV) is the most common congenital heart malformation frequently associated with ascending aortic a...
Upregulation of glycolytic enzyme PFKFB3 by deubiquitinase OTUD4 promotes cardiac fibrosis post myocardial infarction
Upregulation of glycolytic enzyme PFKFB3 by deubiquitinase OTUD4 promotes cardiac fibrosis post myocardial infarction
Metabolic dysregulations have emerged as a major mediator of cardiovascular disorders and fibrotic diseases. Metabolic rep...
Myeloid-specific deletion of chitinase-3-like 1 protein ameliorates murine diet-induced steatohepatitis progression
Myeloid-specific deletion of chitinase-3-like 1 protein ameliorates murine diet-induced steatohepatitis progression
Chitinase-3-like 1 protein (CHI3L1) is a secreted glycoprotein, strongly correlated with fibrosis severity in chronic live...
Increased Fusobacterium tumoural abundance affects immunogenicity in mucinous colorectal cancer and may be associated with improved clinical outcome
Increased Fusobacterium tumoural abundance affects immunogenicity in mucinous colorectal cancer and may be associated with improved clinical outcome
There is currently an urgent need to identify factors predictive of immunogenicity in colorectal cancer (CRC). Mucinous CR...
Kielin/chordin-like protein deficiency causes cardiac aging in male mice
Kielin/chordin-like protein deficiency causes cardiac aging in male mice
Previous studies have demonstrated that bone morphogenetic proteins (BMPs) play important roles in cardiovascular diseases...
NLRP7 participates in the human subcortical maternal complex and its variants cause female infertility characterized by early embryo arrest
NLRP7 participates in the human subcortical maternal complex and its variants cause female infertility characterized by early embryo arrest
Successful human reproduction requires normal oocyte maturation, fertilization, and early embryo development. Early embryo...
PAX5 aberrant expression incorporated in MIPI-SP risk scoring system exhibits additive value in mantle cell lymphoma
PAX5 aberrant expression incorporated in MIPI-SP risk scoring system exhibits additive value in mantle cell lymphoma
Mantle cell lymphoma (MCL) is a subtype of non-Hodgkin lymphoma with highly heterogeneous clinical courses. Paired-box 5 (...
Celastrol-loaded biomimetic nanodrug ameliorates APAP-induced liver injury through modulating macrophage polarization
Celastrol-loaded biomimetic nanodrug ameliorates APAP-induced liver injury through modulating macrophage polarization
Drug-induced liver injury (DILI) is a major concern in clinical treatment as well as postmarketing surveillance, showing a...
TRIM-containing 44 aggravates cardiac hypertrophy via TLR4/NOX4-induced ferroptosis
TRIM-containing 44 aggravates cardiac hypertrophy via TLR4/NOX4-induced ferroptosis
TRIM-containing 44 (TRIM44) is a promoter of multiple cancers. However, its role in cardiac hypertrophy has not been eluci...
SOST gene suppression stimulates osteocyte Wnt/β-catenin signaling to prevent bone resorption and attenuates particle-induced osteolysis
SOST gene suppression stimulates osteocyte Wnt/β-catenin signaling to prevent bone resorption and attenuates particle-induced osteolysis
The most common cause for prosthetic revision surgery is wear particle-induced periprosthetic osteolysis, which leads to a...
Signaling mechanisms involved in the regulation of remyelination in multiple sclerosis: a mini review
Signaling mechanisms involved in the regulation of remyelination in multiple sclerosis: a mini review
Multiple sclerosis is an autoimmune neurodegenerative disease of the CNS that causes progressive disabilities, owing to CN...
E3 ubiquitin ligase on the biological properties of hematopoietic stem cell
E3 ubiquitin ligase on the biological properties of hematopoietic stem cell
Hematopoietic stem cells are a group of heterogeneity cells with the potential to differentiate into various types of matu...
The diagnostic potential of a circRNA–miRNA network in non-small cell lung cancer
The diagnostic potential of a circRNA–miRNA network in non-small cell lung cancer
Increasing studies demonstrate the significant contributions of circRNA-related competitive endogenous RNA (ceRNA) regulat...
G-quadruplexes from non-coding RNAs
G-quadruplexes from non-coding RNAs
Non-coding RNAs (ncRNAs) are significant regulators of gene expression in a wide range of biological processes, such as tr...
Melatonin inhibits senescence-associated melanin pigmentation through the p53-TYR pathway in human primary melanocytes and the skin of C57BL/6 J mice after UVB irradiation
Melatonin inhibits senescence-associated melanin pigmentation through the p53-TYR pathway in human primary melanocytes and the skin of C57BL/6 J mice after UVB irradiation
UVB exposure accelerates skin aging and pigmentation. Melatonin effectively regulates tyrosinase (TYR) activity and aging....
Copper chaperone antioxidant 1: multiple roles and a potential therapeutic target
Copper chaperone antioxidant 1: multiple roles and a potential therapeutic target
Copper (Cu) was recently demonstrated to play a critical role in cellular physiological and biochemical processes, includi...
Non-coding RNAs regulating mitochondrial function in cardiovascular diseases
Non-coding RNAs regulating mitochondrial function in cardiovascular diseases
Cardiovascular disease (CVD) is the leading cause of disease-related death worldwide and a significant obstacle to improvi...
Blocking prokineticin receptors attenuates synovitis and joint destruction in collagen-induced arthritis
Blocking prokineticin receptors attenuates synovitis and joint destruction in collagen-induced arthritis
Rheumatoid arthritis (RA) is a chronic inflammatory disease mediated by an interdependent network of proinflammatory molec...
The role of hypoxia-inducible factor 1α in hepatic lipid metabolism
The role of hypoxia-inducible factor 1α in hepatic lipid metabolism
Chronic liver disease is a major public health problem with a high and increasing prevalence worldwide. In the progression...
Ebola virus–like particles reprogram cellular metabolism
Ebola virus–like particles reprogram cellular metabolism
Ebola virus can trigger a release of pro-inflammatory cytokines with subsequent vascular leakage and impairment of clottin...
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