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Identification of STAT3 and MYC as critical ferroptosis-related biomarkers in septic cardiomyopathy: a bioinformatics and experimental study
Identification of STAT3 and MYC as critical ferroptosis-related biomarkers in septic cardiomyopathy: a bioinformatics and experimental study
Ferroptosis is the well-known mechanism of septic cardiomyopathy (SCM). Bioinformatics analysis was employed to identify f...
Manic Fringe promotes endothelial-to-mesenchymal transition mediated by the Notch signalling pathway during heart valve development
Manic Fringe promotes endothelial-to-mesenchymal transition mediated by the Notch signalling pathway during heart valve development
A fundamental event in the formation of heart valves involves the transformation of endocardial cells within the outflow t...
Effects of iron overload in human joint tissue explant cultures and animal models
Effects of iron overload in human joint tissue explant cultures and animal models
Osteoarthritis (OA) is a prevalent degenerative joint disease affecting over 530 million individuals worldwide. Recent stu...
Abnormally accumulated GM2 ganglioside contributes to skeletal deformity in Tay-Sachs mice
Abnormally accumulated GM2 ganglioside contributes to skeletal deformity in Tay-Sachs mice
Tay-Sachs Disease is a rare lysosomal storage disorder caused by mutations in the HEXA gene, responsible for the degradati...
Synergistic effect of the sphingosine kinase inhibitor safingol in combination with 2'-nitroflavone in breast cancer
Synergistic effect of the sphingosine kinase inhibitor safingol in combination with 2'-nitroflavone in breast cancer
Sphingosine kinase-1 (SPHK1), the enzyme that catalyzes the synthesis of the pro-oncogenic molecule sphingosine-1-phosphat...
Polo-like kinase 2 targeting as novel strategy to sensitize mutant p53-expressing tumor cells to anticancer treatments
Polo-like kinase 2 targeting as novel strategy to sensitize mutant p53-expressing tumor cells to anticancer treatments
Polo-like kinase 2 (Plk2) belongs to a family of serine/threonine kinases, and it is involved in tumorigenesis of diverse ...
Therapy concepts in type 1 diabetes mellitus treatment: disease modifying versus curative approaches
Therapy concepts in type 1 diabetes mellitus treatment: disease modifying versus curative approaches
For many autoimmune diseases, including type 1 diabetes mellitus (T1DM), efforts have been made to modify the disease proc...
Hypoxia drives estrogen receptor β-mediated cell growth via transcription activation in non-small cell lung cancer
Hypoxia drives estrogen receptor β-mediated cell growth via transcription activation in non-small cell lung cancer
Non-small cell lung cancer (NSCLC) is a highly malignant tumor with a poor prognosis. Hypoxia conditions affect multiple c...
Emerging technologies in regenerative medicine: The future of wound care and therapy
Emerging technologies in regenerative medicine: The future of wound care and therapy
Wound healing, an intricate biological process, comprises orderly phases of simple biological processed including hemostas...
Umbelliferone alleviates impaired wound healing and skin barrier dysfunction in high glucose-exposed dermal fibroblasts and diabetic skins
Umbelliferone alleviates impaired wound healing and skin barrier dysfunction in high glucose-exposed dermal fibroblasts and diabetic skins
Skin wound healing is a complex process involving various cellular and molecular events. However, chronic wounds, particul...
The oncogenic role of EIF4A3/CDC20 axis in the endometrial cancer
The oncogenic role of EIF4A3/CDC20 axis in the endometrial cancer
Eukaryotic initiation factor 4A-3 (EIF4A3) is a key component of the exon junction complex (EJC) and is extensively involv...
Extragustatory bitter taste receptors in head and neck health and disease
Extragustatory bitter taste receptors in head and neck health and disease
Taste receptors, first described for their gustatory functions within the oral cavity and oropharynx, are now known to be ...
Constitutive expression of the deubiquitinating enzyme CYLD does not affect microglia phenotype or function in homeostasis and neuroinflammation
Constitutive expression of the deubiquitinating enzyme CYLD does not affect microglia phenotype or function in homeostasis and neuroinflammation
The deubiquitinating enzyme CYLD negatively regulates NF-κB signaling by removing activating ubiquitin chains from se...
The role of circular RNA targeting IGF2BPs in cancer—a potential target for cancer therapy
The role of circular RNA targeting IGF2BPs in cancer—a potential target for cancer therapy
Circular RNAs (circRNAs) are an interesting class of conserved single-stranded RNA molecules derived from exon or intron s...
Molecular mechanisms of thalidomide effectiveness on COVID-19 patients explained: ACE2 is a new ΔNp63α target gene
Molecular mechanisms of thalidomide effectiveness on COVID-19 patients explained: ACE2 is a new ΔNp63α target gene
COVID-19 pandemic is caused by the SARS-CoV-2 virus, whose internalization and infection are mediated by the angiotensin-c...
Revising pathogenesis of AP1S1-related MEDNIK syndrome: a missense variant in the AP1S1 gene as a causal genetic lesion
Revising pathogenesis of AP1S1-related MEDNIK syndrome: a missense variant in the AP1S1 gene as a causal genetic lesion
MEDNIK syndrome is a rare autosomal recessive disease characterized by mental retardation, enteropathy, deafness, peripher...
Prefrontal cortex astrocytes in major depressive disorder: exploring pathogenic mechanisms and potential therapeutic targets
Prefrontal cortex astrocytes in major depressive disorder: exploring pathogenic mechanisms and potential therapeutic targets
Major depressive disorder (MDD) is a prevalent mental health condition characterized by persistent feelings of sadness and...
Exosomal miR-21-5p derived from endometrial stromal cells promotes angiogenesis by targeting TIMP3 in ovarian endometrial cysts
Exosomal miR-21-5p derived from endometrial stromal cells promotes angiogenesis by targeting TIMP3 in ovarian endometrial cysts
Endometriosis is a multifactorial gynecological disease, with angiogenesis as a key hallmark. The role of exosomal microRN...
Epigenetic profiles in blood and adipose tissue: identifying strong correlations in morbidly obese and non-obese patients
Epigenetic profiles in blood and adipose tissue: identifying strong correlations in morbidly obese and non-obese patients
Epigenetic alterations play a pivotal role in conditions influenced by environmental factors such as overweight and obesit...
Current treatment of Psoriasis triggered by Cytokine Storm and future immunomodulation strategies
Current treatment of Psoriasis triggered by Cytokine Storm and future immunomodulation strategies
Psoriasis is a chronic condition caused by an inflammation mediated mainly by cytokines and T cells. In COVID-19, the same...
Endoplasmic reticulum stress induces hepatic steatosis through interaction between PPARα and FoxO6 in vivo and in vitro
Endoplasmic reticulum stress induces hepatic steatosis through interaction between PPARα and FoxO6 in vivo and in vitro
Endoplasmic reticulum (ER) stress is a major cause of hepatic steatosis through increasing de novo lipogenesis. Forkhead b...
TRAP1 modulates mitochondrial biogenesis via PGC-1α/TFAM signalling pathway in colorectal cancer cells
TRAP1 modulates mitochondrial biogenesis via PGC-1α/TFAM signalling pathway in colorectal cancer cells
Metabolic rewiring promotes cancer cell adaptation to a hostile microenvironment, representing a hallmark of cancer. This ...
New CRISPR/Cas9-based Fgfr2C361Y/+ mouse model of Crouzon syndrome exhibits skull and behavioral abnormalities
New CRISPR/Cas9-based Fgfr2C361Y/+ mouse model of Crouzon syndrome exhibits skull and behavioral abnormalities
Crouzon syndrome (CS), a syndromic craniosynostosis, is a craniofacial developmental deformity caused by mutations in fibr...
Protective role of M3 muscarinic acetylcholine receptor in indomethacin-induced small intestinal injury
Protective role of M3 muscarinic acetylcholine receptor in indomethacin-induced small intestinal injury
EP4 prostanoid receptor (EP4R) contributes to the intestinal epithelial Cl− secretion, and inhibition of prostagland...
WNT2B high‑expressed fibroblasts induce the fibrosis of IBD by promoting NK cells secreting IL-33
WNT2B high‑expressed fibroblasts induce the fibrosis of IBD by promoting NK cells secreting IL-33
Fibrosis is an important pathological change in inflammatory bowel disease (IBD), but the mechanism has yet to be elucidat...
Oral pyrophosphate protects Abcc6-/- mice against vascular calcification induced by chronic kidney disease
Oral pyrophosphate protects Abcc6-/- mice against vascular calcification induced by chronic kidney disease
One of the hallmarks of chronic kidney disease (CKD) is the development of vascular calcification. Inorganic pyrophosphate...
New insights into the mechanisms and therapeutic strategies of chondrocyte autophagy in osteoarthritis
New insights into the mechanisms and therapeutic strategies of chondrocyte autophagy in osteoarthritis
Osteoarthritis (OA) is a chronic joint disease with an unclear cause characterized by secondary osteophytes and degenerati...
β-Adrenergic blockade attenuates adverse adipose tissue responses after burn
β-Adrenergic blockade attenuates adverse adipose tissue responses after burn
Severe burn injuries are defined by a prolonged hypermetabolic response characterized by increases in resting energy expen...
The caspase-inhibitor Emricasan efficiently counteracts cisplatin- and neomycin-induced cytotoxicity in cochlear cells
The caspase-inhibitor Emricasan efficiently counteracts cisplatin- and neomycin-induced cytotoxicity in cochlear cells
Cisplatin is a chemotherapeutic agent widely used to treat solid tumors. However, it can also be highly ototoxic, resultin...
MicroRNAs role in telomere length maintenance and telomerase activity in tumor cells
MicroRNAs role in telomere length maintenance and telomerase activity in tumor cells
MiRNAs, a class of non-coding RNA molecules, have emerged as critical modulators of telomere length and telomerase activit...
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