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The role of annexins in central nervous system development and disease
The role of annexins in central nervous system development and disease
Annexins, a group of Ca2+-dependent phospholipid-binding proteins, exert diverse roles in neuronal development, normal cen...
The role of the immunosuppressive PD-1/PD-L1 checkpoint pathway in the aging process and age-related diseases
The role of the immunosuppressive PD-1/PD-L1 checkpoint pathway in the aging process and age-related diseases
The accumulation of senescent cells within tissues is a hallmark of the aging process. Senescent cells are also commonly p...
Metabolomic profiling of maternal plasma identifies inverse associations of acetate and urea with anti-SARS-CoV-2 antibody titers following COVID-19 vaccination during pregnancy
Metabolomic profiling of maternal plasma identifies inverse associations of acetate and urea with anti-SARS-CoV-2 antibody titers following COVID-19 vaccination during pregnancy
We conducted a comprehensive metabolomic analysis of plasma samples obtained from pregnant women who displayed varying pos...
Abnormal protein SUMOylation in liver disease: novel target for therapy
Abnormal protein SUMOylation in liver disease: novel target for therapy
SUMOylation is an important protein post-translational modification (PTM) process, in which the small ubiquitin-like modif...
Ischemic stroke and diabetes: a TLR4-mediated neuroinflammatory perspective
Ischemic stroke and diabetes: a TLR4-mediated neuroinflammatory perspective
Ischemic stroke is the major contributor to morbidity and mortality in people with diabetes mellitus. In ischemic stroke p...
Pathogenic effects of Leu200Pro and Arg387His VRK1 protein variants on phosphorylation targets and H4K16 acetylation in distal hereditary motor neuropathy
Pathogenic effects of Leu200Pro and Arg387His VRK1 protein variants on phosphorylation targets and H4K16 acetylation in distal hereditary motor neuropathy
Rare recessive variants in the human VRK1 gene are associated with several motor neuron diseases (MND), such as amyotrophi...
An Hsp70 promoter–based mouse for heat shock–induced gene modulation
An Hsp70 promoter–based mouse for heat shock–induced gene modulation
Physical therapy is extensively employed in clinical settings. Nevertheless, the absence of suitable animal models has res...
Exploiting the therapeutic potential of contracting skeletal muscle-released extracellular vesicles in cancer: Current insights and future directions
Exploiting the therapeutic potential of contracting skeletal muscle-released extracellular vesicles in cancer: Current insights and future directions
The health benefits of exercise training in a cancer setting are increasingly acknowledged; however, the underlying molecu...
How calorie restriction slows aging: an epigenetic perspective
How calorie restriction slows aging: an epigenetic perspective
Genomic instability and epigenetic alterations are some of the prominent factors affecting aging. Age-related heterochroma...
Blockade of aryl hydrocarbon receptor restricts omeprazole-induced chronic kidney disease
Blockade of aryl hydrocarbon receptor restricts omeprazole-induced chronic kidney disease
Chronic kidney disease (CKD) is the 16th leading cause of mortality worldwide. Clinical studies have raised that long-term...
NLRC3 attenuates osteoclastogenesis by limiting TNFα+ Th17 cell response in osteoporosis
NLRC3 attenuates osteoclastogenesis by limiting TNFα+ Th17 cell response in osteoporosis
NOD-like receptor family CARD domain containing 3 (NLRC3) is the intracellular protein belonging to NLR (NOD-like receptor...
Decreased circulating CTRP3 levels in acute and chronic cardiovascular patients
Decreased circulating CTRP3 levels in acute and chronic cardiovascular patients
C1q/TNF-related protein 3 (CTRP3) represents an adipokine with various metabolic and immune-regulatory functions. While ci...
Physiological and pathological effects of phase separation in the central nervous system
Physiological and pathological effects of phase separation in the central nervous system
Phase separation, also known as biomolecule condensate, participates in physiological processes such as transcriptional re...
Macrophage activation contributes to diabetic retinopathy
Macrophage activation contributes to diabetic retinopathy
Diabetic retinopathy (DR) is recognized as a neurovascular complication of diabetes, and emerging evidence underscores the...
Systematic and quantitative analysis of stop codon readthrough in Rett syndrome nonsense mutations
Systematic and quantitative analysis of stop codon readthrough in Rett syndrome nonsense mutations
Rett syndrome (RTT) is a neurodevelopmental disorder resulting from genetic mutations in the methyl CpG binding protein 2 ...
The therapeutic effect of mesenchymal stem cells in diabetic kidney disease
The therapeutic effect of mesenchymal stem cells in diabetic kidney disease
Diabetes mellitus (DM) often causes chronic kidney damage despite best medical practices. Diabetic kidney disease (DKD) ar...
The complement factor H-related protein-5 (CFHR5) exacerbates pathological bone formation in ankylosing spondylitis
The complement factor H-related protein-5 (CFHR5) exacerbates pathological bone formation in ankylosing spondylitis
Ankylosing spondylitis (AS) is a chronic inflammatory disease, characterized by excessive new bone formation. We previousl...
The role of regulated necrosis in diabetes and its complications
The role of regulated necrosis in diabetes and its complications
Morphologically, cell death can be divided into apoptosis and necrosis. Apoptosis, which is a type of regulated cell death...
Targeting EphA2: a promising strategy to overcome chemoresistance and drug resistance in cancer
Targeting EphA2: a promising strategy to overcome chemoresistance and drug resistance in cancer
Erythropoietin-producing hepatocellular A2 (EphA2) is a vital member of the Eph tyrosine kinase receptor family and has be...
Systemic and local effect of oxidative stress on recurrent aphthous stomatitis: systematic review
Systemic and local effect of oxidative stress on recurrent aphthous stomatitis: systematic review
Recurrent aphthous stomatitis (RAS) is a chronic and recurrent inflammatory disease of the mouth. It is characterised by t...
Novel high-yield potato protease inhibitor panels block a wide array of proteases involved in viral infection and crucial tissue damage
Novel high-yield potato protease inhibitor panels block a wide array of proteases involved in viral infection and crucial tissue damage
Viruses critically rely on various proteases to ensure host cell entry and replication. In response to viral infection, th...
Current knowledge of bone-derived factor osteocalcin: its role in the management and treatment of diabetes mellitus, osteoporosis, osteopetrosis and inflammatory joint diseases
Current knowledge of bone-derived factor osteocalcin: its role in the management and treatment of diabetes mellitus, osteoporosis, osteopetrosis and inflammatory joint diseases
Osteocalcin (OC) is the most abundant non-collagenous and osteoblast-secreted protein in bone. It consists of two forms su...
FDA-approved disulfiram as a novel treatment for aggressive leukemia
FDA-approved disulfiram as a novel treatment for aggressive leukemia
Acute leukemia continues to be a major cause of death from disease worldwide and current chemotherapeutic agents are assoc...
High expression of BCAT1 sensitizes AML cells to PARP inhibitor by suppressing DNA damage response
High expression of BCAT1 sensitizes AML cells to PARP inhibitor by suppressing DNA damage response
Previous evidence has confirmed that branched-chain aminotransferase-1 (BCAT1), a key enzyme governing branched-chain amin...
Etiopathogenesis of medication-related osteonecrosis of the jaws: a review
Etiopathogenesis of medication-related osteonecrosis of the jaws: a review
This study compiles the main hypotheses involved in the etiopathogenesis of medication-related osteonecrosis of the jaw (M...
Ubiquitination and deubiquitination in the regulation of N6-methyladenosine functional molecules
Ubiquitination and deubiquitination in the regulation of N6-methyladenosine functional molecules
N6 methyladenosine (m6A) is the most prevalent RNA epigenetic modification, regulated by methyltransferases and demethyltr...
Traumatic brain injury-induced disruption of the circadian clock
Traumatic brain injury-induced disruption of the circadian clock
Disturbances in the circadian rhythm have been reported in patients following traumatic brain injury (TBI). However, the r...
Evidence for alterations in lipid profiles and biophysical properties of lipid rafts from spinal cord in sporadic amyotrophic lateral sclerosis
Evidence for alterations in lipid profiles and biophysical properties of lipid rafts from spinal cord in sporadic amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is an age-dependent neurodegenerative disease affecting motor neurons in the spinal co...
Circular RNAs: Regulators of endothelial cell dysfunction in atherosclerosis
Circular RNAs: Regulators of endothelial cell dysfunction in atherosclerosis
Endothelial cell (EC) dysfunction is associated with atherosclerosis. Circular RNAs (circRNAs) are covalently closed loops...
Correction to: Evaluation of EpCAM-specific exosomal lncRNAs as potential diagnostic biomarkers for lung cancer using droplet digital PCR
Correction to: Evaluation of EpCAM-specific exosomal lncRNAs as potential diagnostic biomarkers for lung cancer using droplet digital PCR
Department of Thoracic Surgery, The Affiliated Hospital of Medical School of Ningbo University, 247 Renmin Road, Ningbo, 3...
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