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CTHRC1 promotes colorectal cancer progression by recruiting tumor-associated macrophages via up-regulation of CCL15
CTHRC1 promotes colorectal cancer progression by recruiting tumor-associated macrophages via up-regulation of CCL15
Tumor-associated macrophages (TAMs) represent a key factor in the tumor immune microenvironment (TME), exerting significan...
A gene therapy targeting medium-chain acyl-CoA dehydrogenase (MCAD) did not protect against diabetes-induced cardiac pathology
A gene therapy targeting medium-chain acyl-CoA dehydrogenase (MCAD) did not protect against diabetes-induced cardiac pathology
Diabetic cardiomyopathy describes heart disease in patients with diabetes who have no other cardiac conditions but have a ...
The role of CD146 in renal disease: from experimental nephropathy to clinics
The role of CD146 in renal disease: from experimental nephropathy to clinics
Vascular endothelial dysfunction is a major risk factor in the development of renal diseases. Recent studies pointed out a...
IL-23 contributes to Particulate Matter induced allergic asthma in the early life of mice and promotes asthma susceptibility
IL-23 contributes to Particulate Matter induced allergic asthma in the early life of mice and promotes asthma susceptibility
Air pollutant exposure leads to and exacerbates respiratory diseases. Particulate Matter (PM) is a major deleterious facto...
Sphingolipids: drivers of cardiac fibrosis and atrial fibrillation
Sphingolipids: drivers of cardiac fibrosis and atrial fibrillation
Sphingolipids (SLs) are vital constituents of the plasma membrane of animal cells and concurrently regulate numerous cellu...
Effects of different amosite preparations on macrophages, lung damages, and autoimmunity
Effects of different amosite preparations on macrophages, lung damages, and autoimmunity
The underlying mechanisms of asbestos-related autoimmunity are poorly understood. As the size, surface reactivity, and fre...
Metabolomics reveals that chronic restraint stress alleviates carbon tetrachloride-induced hepatic fibrosis through the INSR/PI3K/AKT/AMPK pathway
Metabolomics reveals that chronic restraint stress alleviates carbon tetrachloride-induced hepatic fibrosis through the INSR/PI3K/AKT/AMPK pathway
Hepatic fibrosis (HF) could be developed into liver cirrhosis or even hepatocellular carcinoma. Stress has an important ro...
Comparing plasma and skin imprint metabolic profiles in COVID-19 diagnosis and severity assessment
Comparing plasma and skin imprint metabolic profiles in COVID-19 diagnosis and severity assessment
As SARS-CoV-2 continues to produce new variants, the demand for diagnostics and a better understanding of COVID-19 remain ...
Progress in diagnosis and treatment of Leber’s hereditary optic neuropathy
Progress in diagnosis and treatment of Leber’s hereditary optic neuropathy
Leber’s hereditary optic neuropathy (LHON) is a mitochondrial genetic disease with central vision loss as the main s...
Correction to: Downregulation of microRNA-193a-3p is involved in invertebral disc degeneration by targeting MMP14
Correction to: Downregulation of microRNA-193a-3p is involved in invertebral disc degeneration by targeting MMP14
The authors were notified of error that occurred in Fig. 5E of the above paper. The abscissa axis of Fig. 5E should be the...
Identifying survival of pan-cancer patients under immunotherapy using genomic mutation signature with large sample cohorts
Identifying survival of pan-cancer patients under immunotherapy using genomic mutation signature with large sample cohorts
Although immune checkpoint inhibitors have led to durable clinical response in multiple cancers, only a small proportion o...
Correction to: Microdevices for cancer stem cell culture as a predictive chemotherapeutic response platform
Correction to: Microdevices for cancer stem cell culture as a predictive chemotherapeutic response platform
Facultad de Ciencias Médicas, Instituto de Oncología “Ángel H. Roffo”, Área de Investigación, Universidad de Buenos Aires,...
Two-trace two-dimensional correlation spectra (2T2D-COS) analysis using FTIR spectra to monitor the immune response by COVID-19
Two-trace two-dimensional correlation spectra (2T2D-COS) analysis using FTIR spectra to monitor the immune response by COVID-19
There is a growing trend in using saliva for SARS-CoV-2 detection with reasonable accuracy. We have studied the responses ...
Correction to: Myeloid‑specific deletion of chitinase‑3‑like 1 protein ameliorates murine diet‑induced steatohepatitis progression
Correction to: Myeloid‑specific deletion of chitinase‑3‑like 1 protein ameliorates murine diet‑induced steatohepatitis progression
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Autophagy and nuclear morphometry are associated with histopathologic features in esophageal squamous cell carcinoma
Autophagy and nuclear morphometry are associated with histopathologic features in esophageal squamous cell carcinoma
Less than 15% of patients with esophageal squamous cell carcinoma (ESCC) survive 5 years after diagnosis. A bette...
Syncytin-1, syncytin-2 and suppressyn in human health and disease
Syncytin-1, syncytin-2 and suppressyn in human health and disease
In this review, we summarized the results of experimental and clinical studies about three human endogenous retro...
Soluble LDL-receptor is induced by TNF-α and inhibits hepatocytic clearance of LDL-cholesterol
Soluble LDL-receptor is induced by TNF-α and inhibits hepatocytic clearance of LDL-cholesterol
Defective LDL-C clearance and hence its elevation in the circulation is an established risk factor for cardiovascular dise...
Circulating extracellular vesicles are associated with pathophysiological condition including metabolic syndrome-related dysmetabolism in children and adolescents with obesity
Circulating extracellular vesicles are associated with pathophysiological condition including metabolic syndrome-related dysmetabolism in children and adolescents with obesity
Obesity of children and adolescents (OCA) is often accompanied by metabolic syndrome (MetS), which often leads to adult ob...
Periostin secreted by cancer-associated fibroblasts promotes cancer progression and drug resistance in non-small cell lung cancer
Periostin secreted by cancer-associated fibroblasts promotes cancer progression and drug resistance in non-small cell lung cancer
Cancer-associated fibroblasts (CAFs) are important components in the tumor microenvironment, and we sought to identify eff...
Dual roles of UPRer and UPRmt in neurodegenerative diseases
Dual roles of UPRer and UPRmt in neurodegenerative diseases
The unfolded protein response (UPR) is a cellular stress response mechanism induced by the accumulation of unfolded or mis...
Vav2 promotes ductus arteriosus anatomic closure via the remodeling of smooth muscle cells by Rac1 activation
Vav2 promotes ductus arteriosus anatomic closure via the remodeling of smooth muscle cells by Rac1 activation
The ductus arteriosus (DA), bridging the aorta and pulmonary artery, immediately starts closing after birth. Remodeling of...
DNA origami: a tool to evaluate and harness transcription factors
DNA origami: a tool to evaluate and harness transcription factors
Alongside other players, such as CpG methylation and the “histone code,” transcription factors (TFs) represent...
Preferential expression of SCN1A in GABAergic neurons improves survival and epileptic phenotype in a mouse model of Dravet syndrome
Preferential expression of SCN1A in GABAergic neurons improves survival and epileptic phenotype in a mouse model of Dravet syndrome
The SCN1A gene encodes the alpha subunit of a voltage-gated sodium channel (Nav1.1), which is essential for the function o...
Interaction between mitochondria and microbiota modulating cellular metabolism in inflammatory bowel disease
Interaction between mitochondria and microbiota modulating cellular metabolism in inflammatory bowel disease
Inflammatory bowel disease (IBD) is a prototypic complex disease in the gastrointestinal tract that has been increasing in...
E3 ubiquitin ligases in nasopharyngeal carcinoma and implications for therapies
E3 ubiquitin ligases in nasopharyngeal carcinoma and implications for therapies
Nasopharyngeal carcinoma (NPC) is one of the most common squamous cell carcinomas of the head and neck, and Epstein-Barr v...
The role of galectin-3 in atrial fibrillation
The role of galectin-3 in atrial fibrillation
Numerous risk factors for atrial fibrillation (AF) progression have been identified. However, the biomarkers mentioned in ...
The role of LOXL2 induced by glucose metabolism-activated NF-κB in maintaining drug resistance through EMT and cancer stemness in gemcitabine-resistant PDAC
The role of LOXL2 induced by glucose metabolism-activated NF-κB in maintaining drug resistance through EMT and cancer stemness in gemcitabine-resistant PDAC
Gemcitabine is considered a standard treatment for pancreatic cancer, but developing drug resistance greatly limits the ef...
Immunogenic necroptosis in liver diseases: mechanisms and therapeutic potential
Immunogenic necroptosis in liver diseases: mechanisms and therapeutic potential
Necroptosis has received increasing attention and is extensively studied as a recently discovered mode of cell death disti...
Potential role of mesenchymal stem cells in T cell aging
Potential role of mesenchymal stem cells in T cell aging
Immunosenescence occurs with progressive age. T cell aging is manifested by immunodeficiency and inflammation. The main me...
Microdevices for cancer stem cell culture as a predictive chemotherapeutic response platform
Microdevices for cancer stem cell culture as a predictive chemotherapeutic response platform
Microfluidic platforms for clinical use are a promising translational strategy for cancer research specially for drug scre...
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