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Mesenchymal stem cell–derived extracellular vesicles in periodontal bone repair
Mesenchymal stem cell–derived extracellular vesicles in periodontal bone repair
Periodontitis is a chronic inflammatory disease that destroys tooth-supporting structures and poses significant public hea...
The molecular and cellular landscape of hypertrophic cardiomyopathy phenotypes: transition from obstructive to end-stage heart failure
The molecular and cellular landscape of hypertrophic cardiomyopathy phenotypes: transition from obstructive to end-stage heart failure
Hypertrophic cardiomyopathy (HCM) is a myocardial disorder which commonly presents as an obstructive or end-stage disease....
CircRNA CDR1AS promotes cardiac ischemia–reperfusion injury in mice by triggering cardiomyocyte autosis
CircRNA CDR1AS promotes cardiac ischemia–reperfusion injury in mice by triggering cardiomyocyte autosis
Myocardial ischemia/reperfusion (IR) injury is a common adverse event in the clinical treatment of myocardial ischemic dis...
VSMC-specific TRPC1 deletion attenuates angiotensin II-induced hypertension and cardiovascular remodeling
VSMC-specific TRPC1 deletion attenuates angiotensin II-induced hypertension and cardiovascular remodeling
Transient receptor potential canonical 1 (TRPC1) channel, a Ca2+-permeable ion channel widely expressed in vasculature, ha...
Deciphering metabolic shifts in Gaucher disease type 1: a multi-omics study
Deciphering metabolic shifts in Gaucher disease type 1: a multi-omics study
Gaucher disease (GD), an autosomal recessive lysosomal disorder, primarily affects the lysosomal enzyme β-glucocerebr...
Rare variants in cardiomyopathy genes predispose to cardiac injury in severe COVID-19 patients of African or Hispanic ancestry
Rare variants in cardiomyopathy genes predispose to cardiac injury in severe COVID-19 patients of African or Hispanic ancestry
In one of the earliest reports from China during COVID-19, it was noted that over 20% of patients hospitalized with the di...
The role of lncRNA in the differentiation of adipose-derived stem cells: from functions to mechanism
The role of lncRNA in the differentiation of adipose-derived stem cells: from functions to mechanism
Adipose-derived stem cells (ADSCs) have become one of the best seed cells widely studied and concerned in tissue engineeri...
Indole-3-Aldehyde alleviates lung inflammation in COPD through activating Aryl Hydrocarbon Receptor to inhibit HDACs/NF-κB/NLRP3 signaling pathways
Indole-3-Aldehyde alleviates lung inflammation in COPD through activating Aryl Hydrocarbon Receptor to inhibit HDACs/NF-κB/NLRP3 signaling pathways
Indole-3-aldehyde (I3A) is an intestinal microbial metabolite that regulates inflammation in various inflammatory diseases...
Central dopamine receptors: Radiotracers unveiling the Role of dopaminergic tone in obesity
Central dopamine receptors: Radiotracers unveiling the Role of dopaminergic tone in obesity
Brain dopamine type 2 and 3 receptors (D2/3R) have been postulated to play a role in obesity. However, results from molecu...
The role of ceRNAs in breast cancer microenvironmental regulation and therapeutic implications
The role of ceRNAs in breast cancer microenvironmental regulation and therapeutic implications
The tumor microenvironment, which is the tailored physiological milieu of heterogeneous cancer cell populations surrounded...
Molecular characterization of ovarian squamous cell carcinoma originating from mature teratoma
Molecular characterization of ovarian squamous cell carcinoma originating from mature teratoma
Squamous cell carcinoma (SCC) of the ovary, an uncommon form of gynecologic cancer, typically originates from the malignan...
The role of inhibitory immune checkpoint receptors in the pathogenesis of Alzheimer’s disease
The role of inhibitory immune checkpoint receptors in the pathogenesis of Alzheimer’s disease
There is mounting evidence that microglial cells have a key role in the pathogenesis of Alzheimer’s disease (AD). In...
Identification of STAT3 and MYC as critical ferroptosis-related biomarkers in septic cardiomyopathy: a bioinformatics and experimental study
Identification of STAT3 and MYC as critical ferroptosis-related biomarkers in septic cardiomyopathy: a bioinformatics and experimental study
Ferroptosis is the well-known mechanism of septic cardiomyopathy (SCM). Bioinformatics analysis was employed to identify f...
Manic Fringe promotes endothelial-to-mesenchymal transition mediated by the Notch signalling pathway during heart valve development
Manic Fringe promotes endothelial-to-mesenchymal transition mediated by the Notch signalling pathway during heart valve development
A fundamental event in the formation of heart valves involves the transformation of endocardial cells within the outflow t...
Effects of iron overload in human joint tissue explant cultures and animal models
Effects of iron overload in human joint tissue explant cultures and animal models
Osteoarthritis (OA) is a prevalent degenerative joint disease affecting over 530 million individuals worldwide. Recent stu...
Abnormally accumulated GM2 ganglioside contributes to skeletal deformity in Tay-Sachs mice
Abnormally accumulated GM2 ganglioside contributes to skeletal deformity in Tay-Sachs mice
Tay-Sachs Disease is a rare lysosomal storage disorder caused by mutations in the HEXA gene, responsible for the degradati...
Synergistic effect of the sphingosine kinase inhibitor safingol in combination with 2'-nitroflavone in breast cancer
Synergistic effect of the sphingosine kinase inhibitor safingol in combination with 2'-nitroflavone in breast cancer
Sphingosine kinase-1 (SPHK1), the enzyme that catalyzes the synthesis of the pro-oncogenic molecule sphingosine-1-phosphat...
Polo-like kinase 2 targeting as novel strategy to sensitize mutant p53-expressing tumor cells to anticancer treatments
Polo-like kinase 2 targeting as novel strategy to sensitize mutant p53-expressing tumor cells to anticancer treatments
Polo-like kinase 2 (Plk2) belongs to a family of serine/threonine kinases, and it is involved in tumorigenesis of diverse ...
Therapy concepts in type 1 diabetes mellitus treatment: disease modifying versus curative approaches
Therapy concepts in type 1 diabetes mellitus treatment: disease modifying versus curative approaches
For many autoimmune diseases, including type 1 diabetes mellitus (T1DM), efforts have been made to modify the disease proc...
Hypoxia drives estrogen receptor β-mediated cell growth via transcription activation in non-small cell lung cancer
Hypoxia drives estrogen receptor β-mediated cell growth via transcription activation in non-small cell lung cancer
Non-small cell lung cancer (NSCLC) is a highly malignant tumor with a poor prognosis. Hypoxia conditions affect multiple c...
Emerging technologies in regenerative medicine: The future of wound care and therapy
Emerging technologies in regenerative medicine: The future of wound care and therapy
Wound healing, an intricate biological process, comprises orderly phases of simple biological processed including hemostas...
Umbelliferone alleviates impaired wound healing and skin barrier dysfunction in high glucose-exposed dermal fibroblasts and diabetic skins
Umbelliferone alleviates impaired wound healing and skin barrier dysfunction in high glucose-exposed dermal fibroblasts and diabetic skins
Skin wound healing is a complex process involving various cellular and molecular events. However, chronic wounds, particul...
The oncogenic role of EIF4A3/CDC20 axis in the endometrial cancer
The oncogenic role of EIF4A3/CDC20 axis in the endometrial cancer
Eukaryotic initiation factor 4A-3 (EIF4A3) is a key component of the exon junction complex (EJC) and is extensively involv...
Extragustatory bitter taste receptors in head and neck health and disease
Extragustatory bitter taste receptors in head and neck health and disease
Taste receptors, first described for their gustatory functions within the oral cavity and oropharynx, are now known to be ...
Constitutive expression of the deubiquitinating enzyme CYLD does not affect microglia phenotype or function in homeostasis and neuroinflammation
Constitutive expression of the deubiquitinating enzyme CYLD does not affect microglia phenotype or function in homeostasis and neuroinflammation
The deubiquitinating enzyme CYLD negatively regulates NF-κB signaling by removing activating ubiquitin chains from se...
The role of circular RNA targeting IGF2BPs in cancer—a potential target for cancer therapy
The role of circular RNA targeting IGF2BPs in cancer—a potential target for cancer therapy
Circular RNAs (circRNAs) are an interesting class of conserved single-stranded RNA molecules derived from exon or intron s...
Molecular mechanisms of thalidomide effectiveness on COVID-19 patients explained: ACE2 is a new ΔNp63α target gene
Molecular mechanisms of thalidomide effectiveness on COVID-19 patients explained: ACE2 is a new ΔNp63α target gene
COVID-19 pandemic is caused by the SARS-CoV-2 virus, whose internalization and infection are mediated by the angiotensin-c...
Revising pathogenesis of AP1S1-related MEDNIK syndrome: a missense variant in the AP1S1 gene as a causal genetic lesion
Revising pathogenesis of AP1S1-related MEDNIK syndrome: a missense variant in the AP1S1 gene as a causal genetic lesion
MEDNIK syndrome is a rare autosomal recessive disease characterized by mental retardation, enteropathy, deafness, peripher...
Prefrontal cortex astrocytes in major depressive disorder: exploring pathogenic mechanisms and potential therapeutic targets
Prefrontal cortex astrocytes in major depressive disorder: exploring pathogenic mechanisms and potential therapeutic targets
Major depressive disorder (MDD) is a prevalent mental health condition characterized by persistent feelings of sadness and...
Exosomal miR-21-5p derived from endometrial stromal cells promotes angiogenesis by targeting TIMP3 in ovarian endometrial cysts
Exosomal miR-21-5p derived from endometrial stromal cells promotes angiogenesis by targeting TIMP3 in ovarian endometrial cysts
Endometriosis is a multifactorial gynecological disease, with angiogenesis as a key hallmark. The role of exosomal microRN...
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