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Metformin improves cognitive dysfunction through SIRT1/NLRP3 pathway–mediated neuroinflammation in db/db mice
Metformin improves cognitive dysfunction through SIRT1/NLRP3 pathway–mediated neuroinflammation in db/db mice
Diabetes mellitus (DM), an important public health problem, aggravates the global economic burden. Diabetic encephalopathy...
Neutrophil-secreted S100A8/A9 participates in fatty liver injury and fibrosis by promoting myofibroblast migration
Neutrophil-secreted S100A8/A9 participates in fatty liver injury and fibrosis by promoting myofibroblast migration
Fatty liver, which is induced by abnormal lipid metabolism, is one of the most common causes of chronic liver disease glob...
Effect of α7 nAChR-autophagy axis of deciduous tooth pulp stem cells in regulating IL-1β in the process of physiological root resorption of deciduous teeth
Effect of α7 nAChR-autophagy axis of deciduous tooth pulp stem cells in regulating IL-1β in the process of physiological root resorption of deciduous teeth
Physiological root resorption of deciduous teeth is a normal phenomenon occurring during the developmental stages of child...
The role and mechanism of heme oxygenase-1 in arrhythmias
The role and mechanism of heme oxygenase-1 in arrhythmias
The global incidence and prevalence of arrhythmias are continuously increasing. However, the precise mechanisms of underly...
Molecular targets in bone cancer pain: a systematic review of inflammatory cytokines
Molecular targets in bone cancer pain: a systematic review of inflammatory cytokines
Bone cancer pain (BCP) profoundly impacts patient’s quality of life, demanding more effective pain management strate...
PD-1/PD-L1 axis: implications in immune regulation, cancer progression, and translational applications
PD-1/PD-L1 axis: implications in immune regulation, cancer progression, and translational applications
The PD-1/PD-L1 axis is a complex signaling pathway that has an important role in the immune system cells. Programmed cell ...
Aging- and alcohol-associated spatial transcriptomic signature in mouse acute pancreatitis reveals heterogeneity of inflammation and potential pathogenic factors
Aging- and alcohol-associated spatial transcriptomic signature in mouse acute pancreatitis reveals heterogeneity of inflammation and potential pathogenic factors
The rapidly aging population is consuming more alcohol, leading to increased alcohol-associated acute pancreatitis (AAP) w...
CircHIPK3/miR-124 affects angiogenesis in early-onset preeclampsia via CPT1A-mediated fatty acid oxidation
CircHIPK3/miR-124 affects angiogenesis in early-onset preeclampsia via CPT1A-mediated fatty acid oxidation
Multiple theories have been proposed to explain the pathogenesis of early-onset preeclampsia (EOPE), and angiogenic dysfun...
Exploring the role of tRNA-derived small RNAs (tsRNAs) in disease: implications for HIF-1 pathway modulation
Exploring the role of tRNA-derived small RNAs (tsRNAs) in disease: implications for HIF-1 pathway modulation
The tRNA-derived small RNAs (tsRNAs) can be categorized into two main groups: tRNA-derived fragments (tRFs) and tRNA-deriv...
Sex hormone binding globulin (SHBG) modulates mitochondrial dynamics in PPARγ-depleted equine adipose derived stromal cells
Sex hormone binding globulin (SHBG) modulates mitochondrial dynamics in PPARγ-depleted equine adipose derived stromal cells
Peroxisome proliferator-activated receptor gamma (PPARγ) is a transcription factor that promotes adipogenesis, lipid ...
Removal of GIT lesions and the role of impedance of the injection solution—an innovative approach to known methods
Removal of GIT lesions and the role of impedance of the injection solution—an innovative approach to known methods
In this work, for the first time, the specific impedances of various injection solutions as well as the surface and tissue...
Tumor-derived extracellular vesicle proteins as new biomarkers and targets in precision oncology
Tumor-derived extracellular vesicle proteins as new biomarkers and targets in precision oncology
Extracellular vesicles (EVs) are important carriers of signaling molecules, such as nucleic acids, proteins, and lipids, a...
Research progress and application of liver organoids for disease modeling and regenerative therapy
Research progress and application of liver organoids for disease modeling and regenerative therapy
The liver is a major metabolic organ of the human body and has a high incidence of diseases. In recent years, the annual i...
Sphingosine is involved in PAPTP-induced death of pancreas cancer cells by interfering with mitochondrial functions
Sphingosine is involved in PAPTP-induced death of pancreas cancer cells by interfering with mitochondrial functions
Pancreas ductal adenocarcinoma belongs to the most common cancers, but also to the tumors with the poorest prognosis. Here...
Mitochondria targeted esculetin administration improves insulin resistance and hyperglycemia-induced atherosclerosis in db/db mice
Mitochondria targeted esculetin administration improves insulin resistance and hyperglycemia-induced atherosclerosis in db/db mice
The development and progression of hyperglycemia (HG) and HG-associated atherosclerosis are exacerbated by mitochondrial d...
Loss-of-function mutation in DDX53 associated with hereditary spastic paraplegia-like disorder
Loss-of-function mutation in DDX53 associated with hereditary spastic paraplegia-like disorder
DEAD-box helicase 53 (DDX53) is a member of the DEAD-box protein family of RNA helicases. Unlike other family members that...
Non-invasive biomarkers prognostic of decompensation events in NASH cirrhosis: a systematic literature review
Non-invasive biomarkers prognostic of decompensation events in NASH cirrhosis: a systematic literature review
Liver cirrhosis due to nonalcoholic steatohepatitis (NASH) is a life-threatening condition with increasing incidence world...
PCDH11X mutation as a potential biomarker for immune checkpoint therapies in lung adenocarcinoma
PCDH11X mutation as a potential biomarker for immune checkpoint therapies in lung adenocarcinoma
Immune checkpoint inhibitors (ICIs) have achieved impressive success in lung adenocarcinoma (LUAD). However, the response ...
Role and molecular mechanism of NOD2 in chronic non-communicable diseases
Role and molecular mechanism of NOD2 in chronic non-communicable diseases
Nucleotide-binding oligomerization domain containing 2 (NOD2), located in the cell cytoplasm, is a pattern recognition rec...
Mechanism of efferocytosis in atherosclerosis
Mechanism of efferocytosis in atherosclerosis
Atherosclerosis (AS) is a chronic inflammatory vascular disease that occurs in the intima of large and medium-sized arteri...
Blocking H1R signal aggravates atherosclerosis by promoting inflammation and foam cell formation
Blocking H1R signal aggravates atherosclerosis by promoting inflammation and foam cell formation
Atherosclerosis (AS) is a chronic inflammatory arterial disease, in which abnormal lipid metabolism and foam cell...
Myeloid-derived growth factor ameliorates dextran sodium sulfate-induced colitis by regulating macrophage polarization
Myeloid-derived growth factor ameliorates dextran sodium sulfate-induced colitis by regulating macrophage polarization
Inflammatory bowel disease (IBD) is characterized by inflammatory conditions in the gastrointestinal tract. According to r...
Mechanistic complement of autosomal dominant polycystic kidney disease: the role of aquaporins
Mechanistic complement of autosomal dominant polycystic kidney disease: the role of aquaporins
Autosomal dominant polycystic kidney disease is a genetic kidney disease caused by mutations in the genes PKD1 or PKD2. It...
Analysis of the action mechanisms and targets of herbal anticonvulsants highlights opportunities for therapeutic engagement with refractory epilepsy
Analysis of the action mechanisms and targets of herbal anticonvulsants highlights opportunities for therapeutic engagement with refractory epilepsy
Epilepsy is a neurological disorder characterized by spontaneous and recurring seizures. It poses significant therapeutic ...
The role of annexins in central nervous system development and disease
The role of annexins in central nervous system development and disease
Annexins, a group of Ca2+-dependent phospholipid-binding proteins, exert diverse roles in neuronal development, normal cen...
The role of the immunosuppressive PD-1/PD-L1 checkpoint pathway in the aging process and age-related diseases
The role of the immunosuppressive PD-1/PD-L1 checkpoint pathway in the aging process and age-related diseases
The accumulation of senescent cells within tissues is a hallmark of the aging process. Senescent cells are also commonly p...
Metabolomic profiling of maternal plasma identifies inverse associations of acetate and urea with anti-SARS-CoV-2 antibody titers following COVID-19 vaccination during pregnancy
Metabolomic profiling of maternal plasma identifies inverse associations of acetate and urea with anti-SARS-CoV-2 antibody titers following COVID-19 vaccination during pregnancy
We conducted a comprehensive metabolomic analysis of plasma samples obtained from pregnant women who displayed varying pos...
Abnormal protein SUMOylation in liver disease: novel target for therapy
Abnormal protein SUMOylation in liver disease: novel target for therapy
SUMOylation is an important protein post-translational modification (PTM) process, in which the small ubiquitin-like modif...
Ischemic stroke and diabetes: a TLR4-mediated neuroinflammatory perspective
Ischemic stroke and diabetes: a TLR4-mediated neuroinflammatory perspective
Ischemic stroke is the major contributor to morbidity and mortality in people with diabetes mellitus. In ischemic stroke p...
Pathogenic effects of Leu200Pro and Arg387His VRK1 protein variants on phosphorylation targets and H4K16 acetylation in distal hereditary motor neuropathy
Pathogenic effects of Leu200Pro and Arg387His VRK1 protein variants on phosphorylation targets and H4K16 acetylation in distal hereditary motor neuropathy
Rare recessive variants in the human VRK1 gene are associated with several motor neuron diseases (MND), such as amyotrophi...
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