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SUMOylation targeting mitophagy in cardiovascular diseases
SUMOylation targeting mitophagy in cardiovascular diseases
Small ubiquitin-like modifier (SUMO) plays a key regulatory role in cardiovascular diseases, such as cardiac hypertrophy, ...
Underlying mechanisms of epithelial splicing regulatory proteins in cancer progression
Underlying mechanisms of epithelial splicing regulatory proteins in cancer progression
Cancer is the second-leading disease-related cause of global mortality after cardiovascular disease. Despite significant a...
The serotonin receptor 3E variant is a risk factor for female IBS-D
The serotonin receptor 3E variant is a risk factor for female IBS-D
Irritable bowel syndrome (IBS) is a gut-brain disorder of multifactorial origin. Evidence of disturbed serotonergic functi...
Acyloxyacyl hydrolase deficiency induces chronic inflammation and bone loss in male mice
Acyloxyacyl hydrolase deficiency induces chronic inflammation and bone loss in male mice
Hormonal homeostasis is essential in bone remodeling. Recent studies have shown that the treatment of intestinal inflammat...
Transcription factor EB inhibits non-alcoholic fatty liver disease through fibroblast growth factor 21
Transcription factor EB inhibits non-alcoholic fatty liver disease through fibroblast growth factor 21
We sought to explore the potential role of transcription factor EB (TFEB) in the pathogenesis of the non-alcoholic fatty l...
Phase separation in immune regulation and immune-related diseases
Phase separation in immune regulation and immune-related diseases
Phase separation is an emerging paradigm for understanding the biochemical interactions between proteins, DNA, and RNA. Re...
Histone modification in podocyte injury of diabetic nephropathy
Histone modification in podocyte injury of diabetic nephropathy
Diabetic nephropathy (DN), an important complication of diabetic microvascular disease, is one of the leading causes of en...
Polypeptide N-acetylgalactosamine transferase 3: a post-translational writer on human health
Polypeptide N-acetylgalactosamine transferase 3: a post-translational writer on human health
Polypeptide N-acetylgalactosamine transferase 3 (ppGalNAc-T3) is an enzyme involved in the initiation of O-GalNAc glycan b...
The multiple functions of PrPC in physiological, cancer, and neurodegenerative contexts
The multiple functions of PrPC in physiological, cancer, and neurodegenerative contexts
Cellular prion protein (PrPC) is a highly conserved glycoprotein, present both anchored in the cell membrane and soluble i...
TGF-β1/Smad3 upregulates UCA1 to promote liver fibrosis through DKK1 and miR18a
TGF-β1/Smad3 upregulates UCA1 to promote liver fibrosis through DKK1 and miR18a
TGF‐β1 is the strongest cytokine known to promote liver fibrosis. It has been previously demonstrated that the ...
IGFBP2 function as a novel biomarker for active lupus nephritis
IGFBP2 function as a novel biomarker for active lupus nephritis
In search for new targets for the diagnosis and treatment of lupus nephritis (LN), we employed TMT-liquid chromatography-t...
Predictive value of common genetic variants in idiopathic pulmonary fibrosis survival
Predictive value of common genetic variants in idiopathic pulmonary fibrosis survival
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing interstitial pneumonia of unknown etiology. The r...
Adhesion G protein-coupled receptor gluing action guides tissue development and disease
Adhesion G protein-coupled receptor gluing action guides tissue development and disease
Phylogenetic analysis of human G protein-coupled receptors (GPCRs) divides these transmembrane signaling proteins into fiv...
Protective mechanisms of loquat leaf extract and ursolic acid against diabetic pro-inflammation
Protective mechanisms of loquat leaf extract and ursolic acid against diabetic pro-inflammation
The pharmacological effectiveness of loquat leaf extract (LE) and its important component, ursolic acid (UA), in the treat...
New insights into macrophage subsets in atherosclerosis
New insights into macrophage subsets in atherosclerosis
Macrophages in atherosclerotic patients are notably plastic and heterogeneous. Single-cell RNA sequencing (Sc RNA-seq) can...
Uremic mouse model to study vascular calcification and “inflamm-aging”
Uremic mouse model to study vascular calcification and “inflamm-aging”
Calcification and chronic inflammation of the vascular wall is a high-risk factor for cardiovascular mortality, especially...
Serum exosomal coronin 1A and dynamin 2 as neural tube defect biomarkers
Serum exosomal coronin 1A and dynamin 2 as neural tube defect biomarkers
No highly specific and sensitive biomarkers have been identified for early diagnosis of neural tube defects (NTDs). In thi...
Dissecting the role of cell signaling versus CD8+ T cell modulation in propranolol antitumor activity
Dissecting the role of cell signaling versus CD8+ T cell modulation in propranolol antitumor activity
Preclinical and early clinical mechanistic studies of antitumor activity from the beta-adrenergic receptor (β-AR) blo...
mTOR-FABP4 signal is activated in brain arteriovenous malformations in humans
mTOR-FABP4 signal is activated in brain arteriovenous malformations in humans
Arteriovenous malformations (AVMs) are the most common types of cerebral vascular malformations, which are dynamic lesions...
Ataluren suppresses a premature termination codon in an MPS I-H mouse
Ataluren suppresses a premature termination codon in an MPS I-H mouse
Suppressing translation termination at premature termination codons (PTCs), termed readthrough, is a potential therapy for...
Cellular localization of nucleolin determines the prognosis in cancers: a meta-analysis
Cellular localization of nucleolin determines the prognosis in cancers: a meta-analysis
Nucleolin (NCL) is a multifunctional protein expressed in the nucleus, cytoplasm, and cell membrane. Overexpression of NCL...
Aib1 deficiency exacerbates inflammatory responses in acute myocardial infarction mice
Aib1 deficiency exacerbates inflammatory responses in acute myocardial infarction mice
Acute myocardial infarction (AMI) is one of the major causes of death throughout the world, while inflammation has been kn...